Last updated: May 03, 2020 - 02:00 BST

Title Indication Intervention Actions PatientSelection Sponsor Collaborator Country StartDate EndDate Identifiers Phase Recruitment Status Sites Trial Duration Enrollment Count Contacts LastChanged
ARDS Caused by COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinic of Barcelona Ubikare company Spain 2020-03-12 2020-12-31 COVID-19 ARDS, NCT04368975 Phase Not Applicable Recruiting 1 9 Months 500 Carlos Ferrando, Carlos Ferrando, PhD, Sara Darriba, PhD 2020-05-01
Clinical Application of Methylene Blue for Treatment of Covid-19 Patients Coronavirus disease 19 infection MCN (Methylene blue, vitamin C, N-acetyl cysteine) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mashhad University of Medical Sciences Iran 2020-04-19 2020-09-21 IR.MUMS.REC.1399.122, NCT04370288 Phase 1 Clinical Recruiting 1 5 Months 20 Ahmad Bagheri Moghaddam, M.D, Amir Yarahmadi, Ph.D, Daryoush Hamidi Alamdari, Ph.D 2020-05-01
Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia Best Supportive Care alone, ravulizumab alone Complement C5 factor inhibitor, IgG receptor FcRn large subunit p51 modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Alexion Pharmaceuticals Inc 2020-05-31 2021-02-28 ALXN1210-COV-305, NCT04369469 Phase 3 Clinical Not yet recruiting 0 9 Months 270 Alexion Pharmaceuticals, Inc. 2020-05-01
Repeated Measures Trial of Temporary Automated Manual Ventilation Versus Noninvasive Oxygenation or Conventional Vent Coronavirus disease 19 infection, Lung infection, Respiratory failure Mechanical ventilation alone, automated BVM compressor device, Spiro LLC/10x beta alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Massachusetts General Hospital 2020-05-31 2020-11-30 2020P001051, NCT04369274 Phase Not Applicable Not yet recruiting 0 6 Months 30 Blair Parry, CCRC, Keith A Marill, MD 2020-05-01
BATTLE: COVID-19: BCG as Therapeutic Vaccine, Transmission Limitation, and Immunoglobulin Enhancement Coronavirus disease 19 infection BCG vaccine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidade Estadual de Campina Botucatu Medical School, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq, Faculdade de Medicina de Ribeirão Preto, Federal University of Sao Paulo, Instituto de Infectologia Emílio Ribas, Paulinia Municipal Hospital, Pontificia Universidade Catolica de Campinas, State Hospital Dr. Leandro Franceschini Brazil 2020-06-30 2022-05-31 BATTLE, COVID-19 BATTLE TRIAL, NCT04369794 Phase 4 Clinical Not yet recruiting 1 23 Months 1000 Bethania F Nascimento, BSN, Leonardo O Reis, MD, PhD 2020-05-01
Anxiety And Depression During COVID-19 In India Anxiety disorder, Coronavirus disease 19 infection, Depression Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India India 2020-04-24 2021-02-24 COVID-19/MHC/PSYCH/20-10, NCT04369300 Phase Not Applicable Not yet recruiting 1 10 Months 1000 2020-05-01
MATCH: Multi-site Adaptive Trials Using Hydroxycholoroquine for COVID-19 Coronavirus disease 19 infection standard of care alone, famotidine plus hydroxychloroquine Histamine H2 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Northwell Health Inc US 2020-04-07 2021-04-07 20-0268, MATCH, NCT04370262 Phase 3 Clinical Recruiting 0 12 Months 1170 Amanda Tice, RN, Asha Mellor, CCRC, Christina Brennan, MD, John Boockvar, MD, Joseph Conigliaro, MD, Julie DiGregorio, CCRP, Negin Hajizadeh, MD, Neubert Philippe, MD, Patricia Nadraus, RN, Richard Dima, MD, Tamika Wong, MPH 2020-05-01
Trans Thoracic Manipulation of Ventilation/Perfusion: the V/Q Vest Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Respiratory failure V/Q Vest alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Emory University Georgia Institute for Clinical Research, Georgia Institute of Technology US 2020-05-31 2021-03-31 NCT04369599, STUDY00000402 Phase Not Applicable Not yet recruiting 0 10 Months 24 Maxwell Weinmann, MD 2020-05-01
Curie-O-SA: COVID-19 Study of the Serological Response Against the Severe Acute Respiratory Syndrome (SARS) Coronavirus 2 (CoV-2) Virus in 2 Types of Employees, Hospital and Non-hospital, at Institute Curie Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut Curie France 2020-04-28 2021-01-28 Curie-O-SA, IC 2020-07, NCT04369066 Phase Not Applicable Recruiting 1 9 Months 2500 Isabelle Turbiez, Olivier Lantz, MD, Pierre Fumoleau, PhD 2020-05-01
XPro-1595 for the Treatment of Pulmonary Complications From COVID-19 Coronavirus disease 19 infection, Lung disease INB-03 alone, standard of care alone TNF alpha ligand inhibitor Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) INmune Bio Inc 2020-06-30 2021-01-31 NCT04370236, XPRO1595-COVID-19 Phase 2 Clinical Not yet recruiting 0 7 Months 150 Christopher Barnum, PhD 2020-05-01
COVID-19.KDIR.01: Long-term Analysis and Evaluation of morphologic and clinical Parameters in COVID-19 Patients: prospective development of a practical risk score Coronavirus disease 19 infection, Viral pneumonia CT scan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stuttgart Cancer Center Germany 2020-04-17 COVID-19.KDIR.01, DRKS00021537, F-2020-047, U1111-1251-0942 Phase Not Applicable Recruiting 1 150 Götz Martin Richter 2020-05-01
SARS-CoV-2 in tears in patients with COVID-19 Coronavirus disease 19 infection, Ocular disease RT-PCR assay alone, funduscopy alone, slit-lamp examination alone Universitatsklinikum Schleswig-Holstein Campus Kiel Germany 2020-04-29 D 469/20, DRKS00021416 Phase Not Applicable Recruiting 1 30 Mr. Prof. Dr. med. Johann Baptist Roider, Ms. Dr. med. Kristin Hosel 2020-05-01
ATHLOS: Telerehabilitation in Patients With COVID-19 After Hospitalization Coronavirus disease 19 infection aerobic exercise alone, breathing exercise alone, resistive training exercise alone, telerehabilitation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Clinical Exercise Physiology and Rehabilitation Reasearch Laboratory University of Athens, University of Ioannina, University of Thessaly Greece 2020-04-30 2021-03-31 1, ATHLOS, NCT04368845 Phase Not Applicable Not yet recruiting 1 11 Months 100 ELENI KAPRELI, PhD, PT, ELENI KORTIANOU, PhD, PT, Eleni Kortianou 2020-05-01
Management of Covid-19 Patients During Home Isolation Coronavirus disease 19 infection oxygen alone, physical therapy alone Young Adults (18-44 yrs) Cairo University Egypt 2020-03-15 2020-05-20 2318087, NCT04368923 Phase 2 Clinical No longer recruiting 1 2 Months 60 Mahmoud Sedky 2020-05-01
COVID-OZO: Ozone Auto-hemotherapy for COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia ozone auto-hemotherapy alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) L'Institut d Investigacio Biomedica de Girona Hospital Nuestra Señora del Rosario, Sociedad Española de Ozonoterapia Spain 2020-05-04 2020-12-25 COVID-19 NETWORKING GROUP, COVID-OZO, NCT04370223 Phase 3 Clinical Not yet recruiting 4 7 Months 208 Alberto Hernández, MD, PhD, Marc Vives, MD, Marc Vives, MD, PhD 2020-05-01
JoCORE: Acute Cardiovascular Events Triggered by COVID-19-Related Stress Acute stress disorder, Cardiovascular disease, Coronavirus disease 19 infection, Myocardial infarction, Shock, Sudden cardiac death, Ventricular tachycardia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jordan Collaborating Cardiology Group Jordan 2020-04-30 2020-07-30 JCCG.JOCORE.4.4040, JoCORE, NCT04368637 Phase Not Applicable Not yet recruiting 1 3 Months 50 Ayadeh Madanat, MD, Ayman J Hammoudeh, MD, FACC, Ayman J. Hammoudeh, MD, FACC 2020-05-01
VIRUS: Construction of a Composite Clinical-echo Score Predictive of a Risk of Short-term Aggravation of Respiratory Impairment in Patients Suspected of Covid-19 Coronavirus disease 19 infection, Respiratory failure clinical-echo score prediction alone, pleuro-pulmonary ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CHU De Nantes WINFOCUS-France France 2020-04-09 2020-06-30 NCT04370249, RC20_0164, VIRUS Phase Not Applicable Recruiting 1 2 Months 400 Philippe LE CONTE, Philippe LE CONTE, MD-PHD, Philippe PES, MD 2020-05-01
CONFIDODO: Sleep Quality During COVID-19 Containment in Children Whether or Not Usually Followed in Child Psychiatry Anxiety disorder, Coronavirus disease 19 infection, Depression, Sleep disorder routine psychiatric care alone Healthy volunteers accepted, Children (6-12 yrs) Centre Hospitalier René-Dubos France 2020-05-31 2020-06-30 CHRD 0520, CONFIDODO, NCT04370210 Phase Not Applicable Not yet recruiting 1 1 Month 464 Erwan VION, Maryline Delattre, Véronique Da Costa 2020-05-01
Project D: Observational Study to Assess the Seroconversion Status of Health Care Workers and Suspected or Confirmed Cases of COVID-19 Patients Coronavirus disease 19 infection COVID-19 testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India India 2020-04-22 2020-07-30 COVID-19/MHC-2/2020, NCT04368884, Project D Phase Not Applicable Recruiting 1 3 Months 1000 Samreen Siddiqui, PhD, Sujeet Jha, MRCP (U.K), Swati Waghdhare, MD 2020-05-01
Observational Study of COVID-19 Treatment Efficacy Coronavirus disease 19 infection, Respiratory distress syndrome hydroxychloroquine alone, remdesivir alone, azithromycin plus hydroxychloroquine Coronavirus non structural protein 8 modulator, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) OSF Healthcare System US 2020-04-14 2021-04-14 1589936, NCT04369989 Phase Not Applicable Recruiting 0 12 Months 1000 David Hall 2020-05-01
TEACH: Treating COVID-19 With Hydroxychloroquine Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) NYU Langone Health SUNY Downstate Medical Center US 2020-04-15 2020-06-30 20-00463, NCT04369742, TEACH Phase 2 Clinical Recruiting 0 2 Months 626 Jack A. DeHovitz, MD, MPH, MHCDS, FACP, Mark Mulligan, MD, Mark Mulligan, MD, FIDSA, Robert Ulrich, MD 2020-05-01
COVERSCAN: Mapping Organ Health Following COVID-19 Disease Due to SARS-CoV-2 Infection Coronavirus disease 19 infection MRI alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Perspectum Diagnostics Ltd UK 2020-04-21 2023-05-31 20/SC/0185, COVERSCAN, NCT04369807 Phase Not Applicable Recruiting 2 37 Months 507 Mary Norris Xu, BSc, RN, Rajarshi Banerjee, MSc, DPhil, Sandeep Kapur, BSc, MBBS 2020-05-01
Evaluation of the Safety and Immunogenicity of a SARS-CoV-2 rS (COVID-19) Nanoparticle Vaccine With/Without Matrix-M Adjuvant Coronavirus disease 19 infection SARS-CoV recombinant vaccine (nanoparticle), Novavax alone, Matrix M plus SARS-CoV recombinant vaccine (nanoparticle), Novavax Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Novavax Inc Australia 2020-05-15 2021-07-31 2019NCOV-101, NCT04368988 Phase 1/Phase 2 Clinical Not yet recruiting 2 14 Months 131 Biljana Georgievska 2020-05-01
Stroke-Covid19: Covid-19 Epidemic on Acute Stroke Management Coronavirus disease 19 infection, Stroke Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-03-03 2020-04-30 7826, NCT04370197, Stroke-Covid19 Phase Not Applicable Recruiting 1 1 Month 300 Raoul POP, MD, Rémy BEAUJEUX, MD, PhD, Saïd CHAYER, PhD, HDR 2020-05-01
PROTECT: Improving prenatal care during confinement Coronavirus disease 19 infection, Parturition remote consultation alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France 2020-05-01 2021-09-30 2020-A01023-36, NCT04368832, PROTECT Phase Not Applicable Not yet recruiting 0 17 Months 108 Gaëlle Ambroise, Nadine JUGE 2020-05-01
Study to Describe the Safety, Tolerability, Immunogenicity, and Potential Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Adults Coronavirus disease 19 infection Variable regimens including BNT-162a1 , BNT-162b1 , BNT-162b2 , BNT-162c2 COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) BioNTech SE Pfizer Inc US 2020-04-28 2023-01-27 C4591001, NCT04368728 Phase 1/Phase 2 Clinical Not yet recruiting 0 33 Months 8640 Pfizer CT.gov Call Center 2020-05-01
Hydroxychloroquine Chemoprophylaxis for COVID-19 Infection in High-risk Healthcare Workers: Randomized, Controlled Trial Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) SERVICES INSTITUTE OF MEDICAL SCIENCES Pakistan 2020-04-30 2020-10-31 16082019, NCT04370015 Phase 2 Clinical Not yet recruiting 1 6 Months 374 Khadija I Khawaja, FCPS, Saira Burney, FRCP (Edin) 2020-05-01
CORRECT: COvid (Covid-19) Registry REChts der Isar intensive care Trial Adult respiratory distress syndrome, Coronavirus disease 19 infection extracorporeal organ support alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Technical University of Munich Germany 2020-03-30 178/20S, CORRECT, DRKS00021612 Phase Not Applicable Recruiting 1 500 Sebastian Rasch 2020-05-01
TeleCoviDiab: Management of Diabetic Patients With Telemedicine in the Context of the Covid-19 Epidemic Coronavirus disease 19 infection, Insulin dependent diabetes, Non-insulin dependent diabetes teleconsultation alone, telemedicine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital of Strasbourg France 2020-05-31 2020-12-31 7775, NCT04370171, TeleCoviDiab Phase Not Applicable Not yet recruiting 1 7 Months 200 Eric DEMONSANT 2020-05-01
SeCo: Screening for SARS-CoV-2-Infections and Monitoring of Serological Responses to SARS-CoV-2 in Healthcare Workers Coronavirus disease 19 infection Anti-SARS-CoV2 S protein IgG ELISA alone, SARS-CoV-2 PCR alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Medicine Greifswald EUROIMMUN GmbH, Friedrich Loeffler Institute Germany 2020-04-27 2025-05-31 BB 068/20, NCT04370119, SeCo Phase Not Applicable Recruiting 2 61 Months 4000 Andreas Greinacher, Prof.Dr., Christine Rutscher, Dipl.-Med., Henry Völzke, Prof.Dr., Karsten Becker, Prof.Dr., Lena Ulm, Dr., Marek Zygmunt, Prof.Dr., Martin Beer, Prof.Dr., Martin Groschup, Prof.Dr., Matthias Nauck, Prof.Dr., Mladen V. Tzvetkov, Prof.Dr., Nicole Endlich, Prof.Dr., Nils-Olaf Hübner, Prof.Dr., Thomas C. Mettenleiter, Prof.Dr., Wolfgang Schlumberger, Dr. 2020-05-01
PAN-COVID: A global registry of women affected by COVID-19 in pregnancy and their babies, to guide treatment and prevention Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Imperial College London United Kingdom Research & Innovation India, Ecuador, Japan, Lebanon, Mexico, Romania, US, Greece, Belgium, Indonesia, Germany, Russian Federation, UK, Austria, Czech Republic, Brazil, Netherlands, South Africa, Latvia, Bosnia and Herzegovina, Colombia, Nigeria, Spain, Malta, Peru, Thailand, Uganda, United Arab Emirates, Hungary, Italy, Israel, Egypt, Estonia, Chile, Canada, Argentina, Portugal, Guatemala, Tunisia, Australia, Ireland, Qatar 2020-01-01 2021-09-30 20QC5917, IRAS 282655, ISRCTN68026880, PAN-COVID Phase Not Applicable Recruiting 42 21 Months 1000 Dr Mullins 2020-05-01
POCUSars-CoV-2: Accuracy of Lung Ultrasound in the Diagnosis of COVID-19 Pneumonia Coronavirus disease 19 infection, Respiratory disease, Viral pneumonia lung ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Latisana Hospital Italy 2020-04-23 2020-05-31 CEUR-2020-OS-086, NCT04370275, POCUSars-CoV-2 Phase Not Applicable Recruiting 1 1 Month 235 Carmine C Di Gioia, MD, Daniele Orso, MD, Roberto Copetti, MD, Director 2020-05-01
In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity Coronavirus disease 19 infection Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Applied Biology Inc Hospital Universitario Ramon y Cajal Spain 2020-05-01 2020-12-01 AB-IVD-COV-001, NCT04368897 Phase Not Applicable Not yet recruiting 1 7 Months 200 Andy Goren, MD, Carlos Wambier, MD, Sabina Herrera, MD 2020-05-01
Hungarian CoronaVirus Disease-19 Epidemiological Research Coronavirus disease 19 infection Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Semmelweis University Heart and Vascular Center Semmelweis University, University Of Pécs, University of Debrecen, University of Szeged Hungary 2020-05-01 2021-08-01 H-UNCOVER, NCT04370067 Phase Not Applicable Not yet recruiting 4 15 Months 11200 Andor Sebestyén, MD,PhD, Annamaria Kosztin, MD,PhD, Béla Merkely, PhD,DSc, Csaba Lengyel, MD,PhD, Ervin László Berényi, MD,PhD 2020-05-01
Radiographic Findings and Their Temporal Changes in COVID-19 Positive Changes Patients: a Prospective Study Coronavirus disease 19 infection real time reverse transcriptase polymerase chain reaction(rRT-PCR) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Max Healthcare Institute Ltd, India India 2020-04-28 2021-05-30 COVID-19/RFTC/MHC/2020, NCT04368871 Phase Not Applicable Not yet recruiting 1 13 Months 200 Bharat Aggarwal, Rajesh Saxena 2020-05-01
GROCO: Obstetric and Perinatal Outcomes of Women With COVID-19 Coronavirus disease 19 infection Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille France 2020-04-23 2021-04-22 2020-18, GROCO, ID RCB, NCT04369859 Phase Not Applicable Recruiting 1 12 Months 1300 Florence BRETELLE, PU-PH, Jean-Olivier ARNAUD, Director 2020-05-01
C5-COV: C5a Receptor Expression - COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille Innate Pharma SA France 2020-03-31 2020-11-30 2020-14, C5-COV, IDRCB, NCT04369820 Phase Not Applicable Recruiting 1 8 Months 70 Emilie EGP GARRIDO-PRADALIE, Julien CARVELLI, Julien JC CARVELLI, MD, Kahéna AMICHI, Kahéna KA AMICHI, Laurent PAPAZIAN, Lionel VELLY, Marc GAINNIER, Nicolas SCHLEINITZ, Pierre-Yves CORDIER 2020-05-01
C19Survey: The Psychological, Social, and Economic Impacts of COVID-19 Coronavirus disease 19 infection, Psychiatric disorder online survey alone Healthy volunteers accepted, Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Ottawa CHEO Research Institute, Centre for Addiction and Mental Health, Ciusss du Nord-De-L'île-De-Montréal, Hopital Du Sacre-Coeur De Montreal, Johns Hopkins University, McGill University, Ottawa Heart Institute Research Corp, Ottawa Hospital Research Institute, Southlake Regional Health Centre, Sunnybrook Health Sciences Centre, The Royal's Institute of Mental Health Research, Universite De Montreal Canada 2020-04-03 2021-04-03 2131, C19Survey, NCT04369690 Phase Not Applicable Recruiting 10 12 Months 1000 Addo Boafo, MD, Alexander Daros, PhD, CPsych, Cynda Rushton, RN, PhD, Denis Lafortune, PhD, Edward Spilg, FRCP, MSc, Elizaveta Solomonova, PhD, Janet Jeffrey, RN, PhD, Jennifer Phillips, PhD, Jodi Edwards, PhD, Kaitlyn Lopes, Lena Quilty, PhD, CPsych, Mamta Gautam, FRCP MBA, Marie-Hélène Pennestri, PhD, Mysa Saad, MSc, Raj Bhatla, MD FRCPC, Richard H Swartz, MD, PhD, Richard Swartz, MD, PhD, Roger Godbout, PhD, Rébecca Robillard, Rébecca Robillard, PhD, Samuel Paul Louis Veissière, PhD, Tetyana Kendzerska, MD PhD, Tetyana Kendzerska, MD, PhD, Wendy Gifford, RN, PhD, Zachary Kaminsky, PhD 2020-05-01
DigitalDoc: The Digital Doc in the Emergency Department: The solution for patient care in the Covid-19 pandemic? Coronavirus disease 19 infection telemedicine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Maxima Medical Center Netherlands 2020-04-08 2020-09-01 DigitalDoc, NL8522 Phase Not Applicable Recruiting 1 4 Months 50 Bart Candel 2020-05-01
Neuroinvasion in COVID-19 Coronavirus disease 19 infection, Respiratory disease RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zuyderland Medical Center, Heerlen Netherlands 2020-04-26 2020-06-26 NL8526 Phase Not Applicable Not yet recruiting 1 2 Months 10 Floris Smeets 2020-05-02
Volatile Anesthetics in COVID-19 – a pilot study Coronavirus disease 19 infection, Respiratory distress syndrome isoflurane alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitair Medisch Centrum Utrecht Netherlands 2020-04-26 2020-05-31 NL8523 Phase 2 Clinical Not yet recruiting 1 1 Month 20 Jan Dieleman 2020-05-01
Duke COVID-19 Shared Data and Specimen Repository Coronavirus disease 19 infection Duke University US 2020-05-05 2025-04-30 NCT04368234, PRO00105316 Phase Not Applicable Recruiting 0 59 Months 100000 Chris Woods, MD, Lynn Sutton 2020-05-01
COVILUS: Lung Ultrasound to Diagnose COVID-19 Coronavirus disease 19 infection, Respiratory failure lung ultrasound alone, reverse transcription polymerase chain reaction test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens France 2020-04-28 2020-09-28 COVILUS, NCT04368338, PI2020_843_0030 Phase Not Applicable Recruiting 1 5 Months 100 Stéphane Bar, Dr, Stéphane Bar, MD 2020-05-01
SCOPe: To Study the Clinical Characteristics and Treatment Outcome of COVID-19 Patients Admitted in Hospitals of Max Healthcare Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India, Max Super Speciality Hospital India 2020-04-25 2020-07-25 CTRI/2020/04/024859, NCT04367064, SCOPE/MHC/COVID-19/2020, SCOPe Phase Not Applicable Recruiting 1 3 Months 1000 Dr Ram Shankar Mishra, Rajesh Saxena, Rajesh Saxena, MBA, Ram Shankar Mishra, DNB, FRCP, Sandeep Budhiraja, MRCP, FACP 2020-05-01
ELCOVID: Electrocardiogram Analysis in COVID-19 Patients Cardiovascular disease, Coronavirus disease 19 infection blood test alone, cardiac magnetic resonance imaging alone, radiographic examination alone, transthoracic echocardiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Ospedaliero-Universitaria di Ferrara Italy 2020-04-14 2021-12-01 385/2020/OSS/AOUFE, ELCOVID, NCT04367129 Phase Not Applicable Recruiting 1 19 Months 1000 Matteo Bertini, MD, PhD, Michele Malagù, MD 2020-04-30
EuroECMO-COVID: European/Euro-ELSO Survey on Adult and Neonatal/Pediatric COVID-19 Patients in ECMO Cardiogenic shock, Coronavirus disease 19 infection, Lung disease, Septic shock extracorporeal membrane oxygenation alone Maastricht University Medical Center Antwerp University Hospital, Azienda Ospedaliera Citta della Salute e della Scienza di Torino, Azienda Ospedaliero-Universitaria Ospedali Riunit, Azienda Ospedaliero-Universitaria di Udine, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Cardiocentro Ticino, Centre Hospitalier Universitaire Saint Pierre, Centre Hospitalier Universitaire de Liege, Centro Hospitalar Sao Joao, Charles University, Chelyabinsk Regional Clinical Hospital, City Clinical Hospital No. 67, Moscow, Russia, City Hospital No 40, City Hospital No 41, Ekaterinburg, Department of Cardiovascular Surgery, German Heart Center Munich, Erasme Hospital, Erasmus University Medical Center Rotterdam, European chapter of the Extracorporeal Life Support Organization, G Gaslini Children's Hospital, G. Pasquinucci Heart Hospital, Massa, General University Hospital, Prague, Great Ormond Street Hospital for Children NHS Foundation Trust, Guy's & St Thomas' Hospital NHS Trust, Hannover Medical School, Heart Center Leipzig GmbH, Heim Pal Children's Hospital, Henri Mondor Hospital, Herlev Hospital Region Hovedstaden, Hopital Prive La Louviere, Hopital Universitaire de la Pitie Salpetriere, Hopitaux Universitaires De Geneve, Hospices Civils De Lyon, Hospital Miguel Servet, Hospital San Gerardo, Hospital Sant Joan de Deu, Hospital Universitario Ramon y Cajal, Hospital Vall D'Hebron, Hôpital Civil Marie Curie de Charleroi, IRCCS Policlinico San Matteo, Istituto Scientifico H San Raffaele, Karolinska University Hospital, Kemerovo Regional Clinical Cardiological Center named after academician L.S. Barbarash, Klinik Hirslanden, Klinikum Kassel GmbH, Krasnodar Regional Hospital no 1, Landesklinikum Sankt Polten, Leiden University Medical Center, Medical University of Vienna, Medical University of Warsaw, Newcastle Upon Tyne Hospitals NHS Trust, Niguarda Hospital, Novosibirsk City Hospital #2, Onze-Lieve-Vrouwziekenhuis Aalst Hospital, Ospedale Maurizio Bufalini, Ospedale Papa Giovanni XXIII, Ospedale Pediatrico Bambino Gesù (IRCCS), Ospedale S. Giovanni Bosco, Ospedale San Donato, Ospedale Umberto, Ospedale dell'Angelo, Paediatric Intensive Care Glasgow, Politecnico Di Milano, Rennes University Hospital, Rijksuniversiteit te Groningen, Royal Brompton & Harefield NHS Trust, San Bortolo Hosp, San Camillo Hospital, Rome, San Giorgio Clinic, Skåne University Hospital, St. Orsola Hospital, The Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Tirol Kliniken, Universitair Medisch Centrum Utrecht, Universitair Ziekenhuis Brussel, Universitair Ziekenhuis Gent, Universitaire Ziekenhuizen Leuven, Universitat Duisburg Essen, Universitatsklinikum Essen, University General Hospital of Alexandroupolis, University Hospital Basel, University Hospital Regensburg, University Hospital Tubingen, University Hospital, Aachen, University Hospital, Bordeaux, University Hospital, Montpellier, University Hospitals of Leicester - Leicester Royal Infirmary, University of Bern, University of Erlangen-Nurnberg Medical School, University of Lausanne Hospitals, University of Zurich, Universitätklinikum Düsseldorf, Universitätsklinikum Koln, Vilnius University Hospital Santariškių Klinikos Spain, Russian Federation, France, Austria, Israel, Italy, Greece, Czech Republic, Hungary, UK, Sweden, Belgium, Germany, Switzerland, Lithuania, Netherlands, Poland, Denmark, Portugal 2020-04-10 2021-04-30 EuroECMO-COVID, METC 2020-1343, NCT04366921 Phase Not Applicable Recruiting 97 12 Months 150 Aaron Blandino, Ortiz, Alain Combes, Prof., Alberto Weber, Prof. Dr., Alessandro Paradiso, Dr., Alexander Kersten, Dr., Alexander Skopets, Alexandr Turchaninov, Alexandra Shilova, Allesandro Circelli, Dr., Andrea Montalto, Dr., Andrea Moscatelli, Angelo Polito, Antioco Cappai, Dr., Antonella Degani, Antonio Loforte, Dr., Aron Frederik Popov, Prof., Bernard Stockman, Dr., Christian Napp, Dr., Christoph Krapf, Dr., Claire Westrope, Daniel De Backer, Dr., Daniil Shelukhin, Dario Candura, Dr., Dario Fina, Dr., David Schibilsky, Dr., Davide Ghitti, Dr., De Piero, Drs., Dimitri Vandeweghe, Dimitrios Soufleris, Dinis Reis Miranda, Dr., Diyar Saeed, Prof., Edgars Grins, Esther Dreier, Dr., Fabio Taccone, Prof., Felix Hennig, Dr., Finn Moeller Pedersen, Dr., Gabriel Saiydoun, Dr., Gerdy Debeuckelaere, Giacomo Cavallaro, Gianluca Agus, Dr., Gil Bolotin, Dr., Giovanni Chiarini, Dr., Giovenni Landoni, Grünenfelder Jürg, Prof. Dr., Halbe Maximillian, Dr., Harlinde Peperstraete, Ignazio Condello, Igor Komilov, Ivan Akufov, J.J. van der Heijden, Dr., Jacinta Maas, Dr., Jan Belohlavek, Prof., Jan Schmitto, Prof., Jenni Hansjoerg, Jolanda Consiglio, Jordi Riero del Brio, Dr., Judit Llevadias, Justyna Swol, Dr., Katherine Brown, Lars Broman, Dr., Leen Vercaemst, Dr., Lo Coco, Drs., Lorusso, Prof. Dr., Luis Filipe Pinto, Dr., Maged Makhoul, Dr., Malaika Mendoca, Mara Scandroglio, Marc Lagny, Marco Giani, Dr., Marco Moscarelli, Dr., Marco Piccichè, Marco Ranucci, Dr., Maria Elena De Piero, Dr., Mariusz Kowaleswsky, Dr., Mark Davidson, Martin Kneyber, Matteo Di Nardo, Matteo Pozzi, Dr., Matthias Thielman, Prof., Maximillian Malfertheiner, Dr., Michael Piagnerelli, Mirko Belliato, Dr., Nicholas Bartlett, Dr., Nikolaos Bonaros, Prof., Olivier Brissaud, Olivier Germay, Pablo Ruiz, Dr., Paolo Del Sarto, Paolof Meani, Dr., Patrick Biston, Dr., Peter Schellongowski, Dr., Philipp Hen, Dr., Phillipe Gaudard, Pierre Tissieres, Ralf Muellenbach, Prof, Reina Gianfranco, Dr., Robertas Samalavicius, Dr., Roberto Carozza, Roberto Rona, Dr., Romain Courcelle, Roman Komelyuk, Sandrelli Luca, Dr., Sandro Sponga, Dr., Sergei Minin, Simone Schafer, Dr., Susana Segura Matute, Sven Maier, Dr., Thierry Folliguet, Prof., Thomas Doebele, Torje Iuliu, Dr., Udo Boeken, Prof., Vaclav Vobruba, Verna Aquino, Veronika Maraczi, Vito Fanelli, Dr., Xavier Bechtold 2020-05-01
COVID-19 outbreak and solid organ transplantation (SOT): an international, web-based survey Coronavirus disease 19 infection, Organ transplantation Policlinico Universitario Agostino Gemelli Italy 2020-03-24 2020-04-17 COVID-19_V1, NCT04367896 Phase Not Applicable Completed 1 1819 2020-05-01
COVID PRAYER: The COVID-19 ICU PRAYER Study Coronavirus disease 19 infection remote intercessory multi-denominational prayer alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kansas City Heart Rhythm Institute US 2020-05-01 2020-08-31 COVID PRAYER, COVID PRAYER STUDY, NCT04361838 Phase Not Applicable Not yet recruiting 0 4 Months 1000 Dhanunjaya Lakkireddy, MD, Donita Atkins, RN, BSN 2020-05-01
COVID19-CHIEF: COVID-19 Infection in Patients With Hepatocellular Carcinoma Coronavirus disease 19 infection, Hepatocellular carcinoma, Viral pneumonia nasopharyngeal Covid-19 RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens Central Hospital, Nancy, France, Centre Hospitalien Sud Francilien, Centre Hospitalier Intercommunal Creteil, Centre Hospitalier Regional Universitaire de Lille, Centre Hospitalier Universitaire De Nice, Centre Hospitalier Universitaire De Poitiers Etablissement D’Hospitalisation, Centre Hospitalier Universitaire de Toulouse, Hospices Civils De Lyon, Hospital Boisguillaume, Hôpital Paul Brousse, Jean Verdier Hospital, Rennes University Hospital, University Hospital, Bordeaux, University Hospital, Grenoble, University Hospital, Montpellier France 2020-04-27 2020-10-31 COVID19-CHIEF, NCT04367805, PI2020_843_0042 Phase Not Applicable Recruiting 1 6 Months 50 Aurore BARON, MD, Christine SILVAIN, Pr, Eric ASSENAT, Pr, Eric NGUYEN KHAC, Pr, Giuliana AMADDEO, MD, Jean Pierre BRONOWICKI, Pr, Jean-Frédéric BLANC, MD, Jean-Marie PERON, Pr, Julien EDELINE, MD, Mohamed BOUATTOUR, MD, Nathalie GANNE-CARRIE, Pr, Olivier GANRY, Pr, Olivier Ganry, Pr, Philippe MATHURIN, Pr, Philippe MERLE, Pr, Pierre MICHEL, Pr, Rodolphe ANTY, Pr, Thomas DECAENS, Pr, Éric VIBERT, Pr 2020-05-01
ColchiVID: Colchicine Twice Daily During 10 Days as an Option for the Treatment of Symptoms Induced by Inflammation in Patients With Mild and Severe Coronavirus Disease Coronavirus disease 19 infection, Inflammatory disease colchicine (Perrigo) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Instituto Nacional de Ciencias Medicas y Nutricion Mexico 2020-04-27 2021-04-27 337420-21-1, ColchiVID, NCT04367168 Phase 2 Clinical Not yet recruiting 1 12 Months 174 Jose J Torres-Ruiz, MD, MSc, Marina Rull-Gabayet, MD 2020-05-01
Performance of 3 Sampling Methods for the Detection of SARS-CoV-2 (COVID-19) With Real-time Reverse Transcriptase PCR Coronavirus disease 19 infection Dry flocked nasopharyngeal Swab alone, Flocked nasopharyngeal eSwab alone, Flocked oropharynx eSwab alone Healthy volunteers accepted Jessa Hospital Belgium 2020-04-20 2020-05-20 20.43, NCT04361448 Phase Not Applicable Not yet recruiting 1 1 Month 30 Koen Magerman, Reinoud Cartuyvels 2020-05-02
COHORT: Covid-19 Hospitalized Patients Registry Coronavirus disease 19 infection University Hospital Halle Germany 2020-05-03 2020-039, COHORT, DRKS00021575 Phase Not Applicable Not yet recruiting 1 750 Daniel Sedding 2020-05-01
COVBIO: Thrombosis and Covid-19 Coronavirus disease 19 infection, Thrombosis thromboelastometry alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2020-05-31 2020-12-31 69HCL20_0401 - COVBIO, COVBIO, ID-RCB, NCT04366778 Phase Not Applicable Not yet recruiting 1 7 Months 300 Yesim DARGAUD, Pr, Yseim DARGAUD, Pf 2020-05-01
Social Media and COVID-19 Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yale-NUS College Singapore 2020-03-08 2020-05-31 2020-CERC-001B, NCT04367363 Phase Not Applicable Recruiting 1 2 Months 150 Jean Liu, PhD 2020-05-01
Cardiac Injury in COVID-19: a Pathology Study Coronavirus disease 19 infection, Heart injury, Lung disease, Myocardial infarction, Myocarditis, Pulmonary heart disease EKG alone, RNAscope in situ hybridization alone, autopsy alone, cardiac catheterization alone, cardiac sampling alone, dual immunofluorescence alone, echocardiography alone, reverse transcription polymerase chain reaction alone, transmission electron microscopy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ospedale Papa Giovanni XXIII CVPath Institute Italy 2020-04-30 2021-03-31 56/20, NCT04367792 Phase Not Applicable Recruiting 1 11 Months 50 Andrea Gianatti, MD, Antonio Bellasi, MD, CTC CLINICAL TRIAL CENTER, Giulio Guagliumi, MD, Lara Faggi, PhD 2020-05-01
X-Covid 19: Comparison of Two Doses of Enoxaparin for Thromboprophylaxis in Hospitalized COVID-19 Patients Coronavirus disease 19 infection, Thromboembolism enoxaparin sodium alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Niguarda Hospital Italy 2020-05-31 2020-11-30 2020-001708-41, NCT04366960, X-Covid 19 Phase 3 Clinical Not yet recruiting 1 6 Months 2712 Nuccia Morici, MD 2020-05-02
A double-blinded, randomized and placebo-controlled study of trans sodium crocetinate (intravenous), Diffusion Pharmaceuticals in hospitalized COVID-19 patients who have not yet been admitted to an ICU Coronavirus disease 19 infection trans sodium crocetinate (intravenous), Diffusion Pharmaceuticals alone Diffusion Pharmaceuticals LLC, West Virginia University Healthcare US, Eastern Europe Phase Not Applicable Planned 0 Dr. Alex Kadl, Dr. Andrew Southerland 2020-04-30
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection Coronavirus disease 19 infection, Respiratory distress syndrome remestemcel-L alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mesoblast International Sarl Mesoblast Ltd US MSB-MSC-ARDS001, NCT04366830 Phase Not Applicable No longer recruiting 0 50 Mahboob Rahman, MD 2020-05-02
LUCID: Lung Ultrasound in Covid-19 Pneumonia Coronavirus disease 19 infection, Cough, Dyspnea, Respiratory disease, Viral pneumonia computed tomography alone, lung ultrasoound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Vivantes Humboldt-Klinikum Germany 2020-04-24 DRKS00021585, Eth08-20, LUCID Phase Not Applicable Recruiting 1 220 Andreas Umgelter 2020-05-02
SARS-CoV-2 and Surgery Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jagiellonian University Poland 2020-03-30 2020-07-01 1072.6120.103.2020, NCT04368026 Phase Not Applicable Recruiting 2 3 Months 350 Tomasz Stefura, Tomasz Stefura, MD 2020-05-02
A larger, double-blinded, randomized, placebo-controlled study of trans sodium crocetinate (intravenous) to confirm safety in COVID-19 patients who have been admitted to Intensive Care Units (ICUs) Coronavirus disease 19 infection trans sodium crocetinate (intravenous), Diffusion Pharmaceuticals alone Diffusion Pharmaceuticals LLC, West Virginia University Healthcare US Phase Not Applicable Planned 0 Dr. Alex Kadl, Dr. Andrew Southerland 2020-04-30
COR-DIAL-1: Rapid Detection of COVID-19 by Portable and Connected Biosensor Coronavirus disease 19 infection RT-PCR alone, nasopharyngeal swab sampling alone, viral biosensor alone Centre Hospitalier Regional Universitaire de Lille France 2020-05-31 2020-09-30 2020-A01147-32, 2020_36, COR-DIAL-1, NCT04367142 Phase Not Applicable Not yet recruiting 1 4 Months 200 David Devos, MD,PhD, Enagnon Kazali ALIDJINOU, MD 2020-05-02
MolCOVID: Development of a Molecular Diagnostic Strategy for SARS-CoV2 Based on Saliva in the Context of the COVID-19 Pandemic Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Boisguillaume France 2020-04-30 2020-05-31 2020/0094/OB, MolCOVID, NCT04367545 Phase Not Applicable Recruiting 1 1 Month 50 Julien BLOT, Thierry FREBOURG, Pr 2020-05-01
EVIDENCE: COVID-19 Detection Test in Oncology Coronavirus disease 19 infection, Solid tumor enzyme-linked immunosorbent assay (ELISA) alone, rapid diagnostic test (RDT) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The UNICANCER Group France 2020-05-31 2021-05-31 2020-A01002-37, EVIDENCE, NCT04367870, UC-TRA-2002 Phase Not Applicable Not yet recruiting 11 12 Months 2500 Alexandra JACQUET, Aurélien NORET, François-Clément BIDARD, Frédéric VIRET, Georges EMILE, Jean-Baptiste BACHET, Jean-Marc FERRERO, Lionel MOREAU, WILLIAM JACOT 2020-04-30
ScreenNC: A Study to Determine the Number of Asymptomatic Individuals Who Have Antibodies to the Virus That Causes COVID-19 Coronavirus disease 19 infection COVID-19 testing alone, PCR test alone, sequencing alone, swab test alone, viral load testing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of North Carolina US 2020-04-28 2021-04-30 20-0937, NCT04367740, ScreenNC Phase Not Applicable Recruiting 0 12 Months 10000 David B Peden, MD 2020-05-01
ACCORD: ACcelerating COVID-19 Research and Development platform Coronavirus disease 19 infection bemcentinib alone Axl tyrosine kinase receptor inhibitor BerGenBio AS Department of Health and Social Care, IQVIA Holdings Inc, United Kingdom Research & Innovation UK ACCORD Phase 2 Clinical Planned 1 120 2020-04-30
BACT-ovid: Bacteriotherapy in the Treatment of COVID-19 Coronavirus disease 19 infection bacteriotherapy alone, Variable regimens including SivoMixx , azithromycin , darunavir , darunavir + cobicistat , hydroxychloroquine , lopinavir + ritonavir , ritonavir Cytochrome P450 3A4 inhibitor, HIV protease inhibitor, HIV-1 protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universita degli Studi di Roma La Sapienza Italy 2020-03-01 2020-07-31 BACT-ovid, DPHID-UNIROMA05, NCT04368351 Phase Not Applicable No longer recruiting 1 5 Months 70 Gabriella d'Ettorre, MD, PhD, Giancarlo Ceccarelli 2020-05-01
Comorbidites among COVID-19 Mortality Cases Coronavirus disease 19 infection National Institutes of Health Malaysia Malaysia 2020-04-30 54554, NMRR-20-766-54554 Phase Not Applicable Status not specified 1 Hamizatul Akmal Binti Abd Hamid, P Robert Lourdes, Tania Gayle 2020-05-01
Influenza Vaccination, ACEI and ARB in the Evolution of SARS-Covid19 Infection Coronavirus disease 19 infection angiotensin converting enzyme inhibitor therapy alone, angiotensin-receptor blocker therapy alone, influenza vaccine alone Healthy volunteers accepted Consorci Sanitari de Terrassa Catalan Health Service, Jordi Gol i Gurina Foundation Spain 2020-03-01 2023-08-31 02-20-161-021, NCT04367883 Phase Not Applicable Recruiting 1 42 Months 2574 Anna Puigdellívol-Sánchez, Ph D, Anna Puigdellívol-Sánchez, Ph.D., Mar Muñoz 2020-05-02
Health Behavior Change During COVID-19 Pandemic Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) SWPS University of Social Sciences and Humanities Gambia, Malaysia, Australia, China, Singapore, Romania, Israel, Germany, Switzerland, Poland, Canada, Portugal, Italy, France 2020-03-25 2021-03-24 3228-1BPSYPSBEH-30, NCT04367337 Phase Not Applicable Recruiting 14 12 Months 5600 Adriana Baban, PhD, Aleksandra Luszczynska, PhD, Bruno Quintard, PhD, Charles Abraham, PhD, Jan Keller, PhD, Karen Morgan, PhD, Katarzyna Byrka, PhD, Konstadina Griva, PhD, Konstantin Schenkel, MA, Margarida Gaspar de Matos, PhD, Martyna Kuszneruk, MA, Michelle Jongenelis, PhD, Nina Knoll, PhD, Noa Vilchinsky, PhD, Sabrina Cipolletta, PhD, Stephan Dombrowski, PhD, Urte Scholz, PhD, Vishna Shah, PhD, Yiquin Gan, PhD, Yiqun Gan, PhD, Zofia Szczuka, MA 2020-05-02
Stigmatization of Covid-19 patients Coronavirus disease 19 infection Hospital Raja Permaisuri Bainun Malaysia 2020-06-01 54697, NMRR-20-777-54697 Phase Not Applicable Status not specified 1 Chang Chee Tao, Ms. Chew Chii Chii 2020-05-02
Psychological Impairment Due to Covid-19 Anxiety disorder, Coronavirus disease 19 infection, Depression, Psychiatric disorder Healthy volunteers accepted Universitatsklinikum Essen 2020-05-06 2020-05-30 NCT04368312, TEMP553914-BO Phase Not Applicable Not yet recruiting 0 100 Johannes Siebermair, MD 2020-05-02
COVIVA: COVID-19 Survival Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Basel Switzerland 2020-03-19 2021-06-30 COVIVA, NCT04366765, UHOSPITAL SWITZ Phase Not Applicable Recruiting 1 15 Months 1500 Gabriela Kuster Pfister, MD, Raphael Twerenbold, MD 2020-05-02
SAVIOR: Study Assessing Vagus Nerve Stimulation in COVID-19 Respiratory Symptoms Coronavirus disease 19 infection, Respiratory disease GammaCore alone, vagus nerve stimulation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Valencia Spain 2020-04-20 2020-07-31 NCT04368156, SAVIOR, SAVIOR Phase Not Applicable Recruiting 1 3 Months 90 Carlos Tornero, Carlos Tornero, PhD, Natividad Pozo, PhD 2020-05-01
IMPROVE: Intermediate or Prophylactic-Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19 Coronavirus disease 19 infection, Thromboembolism enoxaparin sodium alone, unfractionated heparin alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Columbia University US 2020-05-31 2021-04-30 AAAS8980, IMPROVE, NCT04367831 Phase 4 Clinical Not yet recruiting 0 11 Months 100 Ajay Kirtane, MD, Kate Dalton, Sahil A. Parikh, Sahil Parikh, MD 2020-05-01
Registry to Study Factors That May Impact COVID-19 Occurrence and Severity Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) IQVIA RDS Pty Ltd US 2020-04-02 2022-06-01 IQVIA-COVIDREGISTRY-2020, NCT04368065 Phase Not Applicable Recruiting 0 26 Months 100000 Barbara Arone, MS, Nancy Dreyer, PhD, MPH 2020-05-01
Use of Convalescent Plasma in the treatment of COVID-19 Coronavirus disease 19 infection convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) HILTON PHARMA (PVT) LTD, National Institute of Blood Disease Center Iran 2020-04-14 4-87/NBC-COVID19-/20/03, IRCT20200414047072N1 Phase 2 Clinical Recruiting 1 357 Dr. Arshi Naz, Dr. Neeta Maheshwary, Professor Dr. Tahir S Shamsi, Saba Fatima 2020-05-01
ATTRACT: A phase II, randomized, double-blind, placebo-controlled clinical trial of VP-01 for the tretment of patients with COVID-19, SARS CoV-2 infection Coronavirus disease 19 infection, Respiratory failure VP-01 alone Angiotensin II AT-2 receptor agonist Vicore Pharma AB UK ATTRACT Phase 2 Clinical Not yet recruiting 1 100 Professor Joanna Porter 2020-04-30
Intravascular Access in Suspected/Confirmed COVID-19 Patient Cardiac arrest, Coronavirus disease 19 infection NIO needle set alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lazarski University Medical University of Bialystok, Poznan University of Medical Sciences, Wroclaw Medical University Poland 2020-04-14 2020-05-20 IO_PPE_1, NCT04366947 Phase Not Applicable No longer recruiting 1 1 Month 60 Lukasz Szarpak, Lukasz Szarpak, PhD 2020-05-01
COVID-19BRAIN: Neuroradiolological Analysis of COVID-19 Patients Brain disease, Coronavirus disease 19 infection neurological examination alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-04-03 2021-04-30 7759, COVID-19BRAIN, NCT04368390 Phase Not Applicable Recruiting 1 12 Months 100 Saïd CHAYER, PhD, HDR, Stephane Kremer, MD, PhD, Stéphane KREMER, MD, PhD 2020-05-01
A clinical trial of recombinant protein vaccine for the prevention of COVID-19 infection Coronavirus disease 19 infection recombinant protein vaccine (COVID-19), UMN Pharma Inc alone Shionogi & Co Ltd Japan Phase Not Applicable Planned 1 2020-04-30
Clinical Validation of New Injection Molded Flocked Nasopharyngeal Swabs in Response to the COVID-19 Pandemic Coronavirus disease 19 infection injection molded polypropylene flocked nylon nasopharyngeal swab alone Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Virginia US 2020-04-24 2020-07-31 HSR200127, NCT04368260 Phase Not Applicable Recruiting 0 3 Months 40 Amy Mathers, MD, Limor Steinberg 2020-05-01
COVIDSMELL: Study of the Pathogenesis of Olfactory Disorders in COVID-19 Ageusia, Coronavirus disease 19 infection, Dysomia nasal swab sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut Pasteur Assistance Publique Hopitaux de Paris France 2020-04-30 2022-09-15 2020-021, COVIDSMELL, NCT04366934 Phase Not Applicable Not yet recruiting 1 28 Months 24 Charlotte HAUTEFORT, MD, Françoise LAZARINI, PhD 2020-05-01
RESCUE 1-19: Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19 Coronavirus disease 19 infection, Edema, Viral pneumonia low dose radiation therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Emory University National Cancer Institute US 2020-04-23 2020-07-01 NCI-2020-02676, NCT04366791, P30CA138292, RAD5002-20, RESCUE 1-19, STUDY00000476 Phase 1/Phase 2 Clinical Recruiting 0 2 Months 10 Autumn Lunceford, Clayton B Hess, MD, MPH, Clayton B. Hess, Clayton B. Hess, MD MPH, Clayton Hess, MD, MPH, Mohammad K Khan, MD, PhD, Mohammad K. Khan, MD PhD 2020-05-02
Prospective Registry of Corona Virus Disease 2019 (Covid-19) Patients With Neuromuscular Involvement Coronavirus disease 19 infection electromyography alone, electroneurography alone, muscle ultrasound alone, transthoracic echocardiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Tubingen Germany 2020-03-20 2022-03-31 246/2020BO2, NCT04367350 Phase Not Applicable Recruiting 1 24 Months 500 Alexander Grimm, MD, Helene Häberle, MD, Markus Krumbholz, MD, Sophia Willikens, MD, Sven Poli, MD 2020-05-01
African Covid-19 Critical Care Outcomes Study Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Cape Town University Of Kwazulu-Natal South Africa 2020-05-01 2020-12-31 ACCCOS, NCT04367207 Phase Not Applicable Not yet recruiting 1 8 Months 2000 Bruce Biccard, Bruce M Biccard 2020-05-01
DEPRECOVID: Impact of Giving Birth During the Covid 19 Pandemia on Postnatal Women's Depression Anxiety disorder, Coronavirus disease 19 infection, Depression, Gynecological disorder Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Poitiers Etablissement D’Hospitalisation France 2020-05-31 2020-12-31 2020-A01065-34, DEPRECOVID, NCT04368208 Phase Not Applicable Not yet recruiting 1 7 Months 900 bertarnd GACHON, MD, PhD student 2020-05-01
IRCEP: International Registry of Coronavirus (COVID-19) Exposure in Pregnancy Coronavirus disease 19 infection Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Pregistry Harvard TH Chan School of Public Health US 2020-05-01 2024-04-30 0001, IRCEP, NCT04366986 Phase Not Applicable Not yet recruiting 0 48 Months 25000 Diego Wyszynski, MD, MHS, PhD, Sonia Hernandez-Diaz, MD, DrPH 2020-05-01
reCoVery: Repurposing of Chlorpromazine in Covid-19 Treatment Coronavirus disease 19 infection chlorpromazine alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Sainte Anne Hôpital Cochin France 2020-04-29 2020-09-30 D20-P016, NCT04366739, reCoVery Phase 3 Clinical Not yet recruiting 1 5 Months 40 Marion Plaze, MD, PHD, Raphaël Gaillard, MD, PHD 2020-05-01
COVCKD: Antibody Response Against SARS-CoV-2 in Dialysis Patients During COVID-19 Coronavirus disease 19 infection, Kidney dialysis Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Region Midtjylland Aalborg Hospital, Aarhus University Hospital, Central Jutland Regional Hospital Denmark 2020-03-15 2021-12-01 COVCKD, FHM-1-2020, NCT04367714 Phase Not Applicable Recruiting 1 20 Months 300 Frank Mose, Frank Mose, MD 2020-05-01
MY-CO-VID: Characterization of Fungal Infections in COVID-19 Infected and Mechanically Ventilated Patients in ICU Aspergillus infection, Coronavirus disease 19 infection, Mucor infection, Pneumocystis carinii infection biological sampling alone, polymerase chain reaction alone, real-time polymerase chain reaction alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rennes University Hospital France 2020-04-30 2021-05-31 35RC20_8885_MY_CO_VID, MY-CO-VID, NCT04368221 Phase Not Applicable Not yet recruiting 15 13 Months 250 Achille Kouatchet, Alain Mercat, Anna Novara, Antoine Berry, Beatrice Riu-Poulenc, Carole Schwebel, Christophe Hennequin, Cécile Aubron, Daniele Monbon, Emmanuel Canet, Eric Dannaoui, Feraht Meziani, Florence Persat, Florence Robert-Gangneux, Florent Morio, Francoise Botterel, Frederic Dalle, Frédéric Dalle, Gilles Nevez, Gilles Nevez Nevez, Guillaume Desoubeaux, Jean Christophe Richard, Jean-Francois Timsit, Jean-Marc Tadié, Jean-Philippe Bouchara, Jean-Pierre GANGNEUX, MD, PhD, Jean-Pierre Gangneux, Keyvan Razazi, Laurent Argaud, Marie LE NAOU, Martine Wallon, Muriel Cornet, Muriel Sarrah Fartoukh, Nicolas Terzi, Nicolas de Prost, Patrice Le Pape, Pierre-Francois Dequin, Pierre-François Dequin, Sandrine Houzé, Sophie Brun, Stephane Gaudry, Stéphane Gaudry, Valerie Letcher-Bru, Valérie Letcher-Bru, Xavier Iriart, Yves Cohen, Yves Le Tulzo, cecile Aubron, cécile Aubron 2020-04-30
THROMBOCOVID: Thrombo Embolic Events in Critical Care Patients With Covid-19 Serious Acute Pneumopathy Coronavirus disease 19 infection, Lung disease, Thromboembolism, Viral pneumonia venous ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens France 2020-04-22 2020-09-22 NCT04366752, PI2020_843_0036, THROMBOCOVID Phase Not Applicable Recruiting 1 5 Months 100 Clement Brault, MD, Julien Maizel, Pr, Michel Slama, Pr, Simon Soudet, MD, Yoann Zerbib, MD 2020-05-01
IMSEQ: COVID-19 Immune Repertoire Sequencing Coronavirus disease 19 infection blood sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institute of Tropical Medicine, Belgium Antwerp University Hospital Belgium 2020-04-01 2020-12-31 IMSEQ, IMSEQ, NCT04368143 Phase Not Applicable Recruiting 1 9 Months 100 Koen Vercauteren 2020-05-01
The effect of NBS powder in treatment of patients with COVID-19 Coronavirus disease 19 infection NBS powder alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hamadan University of Medical Sciences Iran 2020-05-09 2020-07-10 IR.UMSHA.REC.1399.046, IRCT20200426047206N1 Phase 3 Clinical Not yet recruiting 1 2 Months 46 Farid Azizi Jalilian 2020-05-01
PIC-19: Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19 Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia Variable regimens including acetylsalicylic acid , clopidogrel , fondaparinux sodium , tirofiban Factor Xa antagonist, GP IIb IIIa antagonist, P2Y12 purinoceptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universita degli Studi di Milano Fondazione Un Cuore per Milano Italy 2020-04-06 2020-04-23 18275/2020, NCT04368377, PIC-19 Phase 2b Clinical Completed 1 5 Pierachille Santus 2020-05-02
Effect of natural from Tahini oil product on corona Coronavirus disease 19 infection Tahini oil alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gonabad University of Medical Sciences Iran 2020-04-30 IR.GMU.REC.1399.014, IRCT20140407017169N2 Phase Not Applicable Not yet recruiting 1 100 Ahmadi Reza, Hossein Mohammadzadeh- Moghadam, Hossein Mohammadzadeh-moghadam 2020-05-01
BEVACOR: Pilot study of bevacizumab as a treatment for respiratory distress in patients with COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome bevacizumab alone VEGF ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundación Para La Investigación Biomédica De Córdoba Spain 2020-04-24 2020-001541-39, BEVACOR, BEVACOR Phase 2 Clinical Recruiting 1 22 Antonio Luque 2020-05-01
Is there a benefit in treating novel corona virus (Sars-CoV2) infections with the established antihypertensive valsartan? Coronavirus disease 19 infection valsartan alone Angiotensin I receptor antagonist, Angiotensin II receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Klinikum St Georg Germany 2020-04-22 2020-001431-27, CovidVal01 Phase 2 Clinical Recruiting 1 300 Geschäftsführung 2020-05-01
Telemedicine in the Covid-19 pandemic in Brazil in a medical clinic in the supplementary health sector in São Paulo, Brazil Coronavirus disease 19 infection telemedicine alone, azithromycin plus hydroxychloroquine Centro Medico Mazzei Brazil 2020-04-01 3.947.259, 30246520.0.0000.0069, A36899523876, RBR-658khm Phase 2 Clinical Recruiting 1 90 Michelle Chechter 2020-05-01
SIDIACO: The Effect of Sitagliptin Treatment in COVID-19 Positive Diabetic Patients Coronavirus disease 19 infection, Non-insulin dependent diabetes, Respiratory failure, Viral pneumonia nutrition intake alone, sitagliptin alone, standard of care alone, insulin plus sitagliptin Dipeptidyl peptidase IV inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universita degli Studi di Milano Italy 2020-04-30 2020-12-30 FBF SACCO, NCT04365517, SIDIACO Phase 3 Clinical Not yet recruiting 1 8 Months 170 Paolo Fiorina, MD, PhD, Teresa Letizia, Dr. 2020-05-02
MERMAIDS 2: European Study of Major Infectious Disease Syndromes Related to COVID-19 Coronavirus disease 19 infection, Respiratory disease, Respiratory tract infection biological sampling alone Universitair Medisch Centrum Utrecht Netherlands 2020-05-01 2022-04-30 MERMAIDS 2, NCT04364711, RECOVER - MERMAIDS 2.0 Phase Not Applicable Not yet recruiting 1 24 Months 2000 MJM Bonten 2020-04-30
Intravascular Access of COVID-19 Patient Under Personal Protective Equipment Coronavirus disease 19 infection NIO alone, Standard intravenous cannula alone, intraosseous access alone, intravenous access alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lazarski University Medical University of Bialystok, Poznan University of Medical Sciences, Wroclaw Medical University Poland 2020-01-12 2020-02-25 IO_PPE_MS_1, NCT04366297 Phase Not Applicable Completed 1 1 Month 41 Jacek Smereka, PhD, Łukasz Szarpak, Assoc Prof PhD 2020-04-30
PROBIOZOVID: Oxygen-Ozone as Adjuvant Treatment in Early Control of COVID-19 Progression and Modulation of the Gut Microbial Flora Coronavirus disease 19 infection oxygen-ozone therapy alone, standard of care alone, Variable regimens including Ozone , SivoMixx , azithromycin , darunavir , darunavir + cobicistat , hydroxychloroquine , lopinavir + ritonavir , ritonavir Cytochrome P450 3A4 inhibitor, HIV protease inhibitor, HIV-1 protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Policlinico Umberto I Italy 2020-03-26 2020-12-31 110/2020, NCT04366089, PROBIOZOVID Phase 2 Clinical Recruiting 1 9 Months 152 Andrea Calò, MD, Carmela Imperiale, MD, Claudio M Mastroianni, MD PhD, Fabio Araimo, MD, Francesco Pugliese, MD PhD, Francesco Pugliese, MD, PhD, Gabriella d'Ettorre, MD PhD, Giancarlo Ceccarelli, MD PhD MSc, Gregorio Egidio Recchia, MD, Paolo Tordiglione, MD PhD, Roberto Poscia MD, Serena Zancla, MD, Vera MAuro, MD 2020-05-01
The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial Coronavirus disease 19 infection hydroxychloroquine alone, standard preventive measures alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University of the Philippines Philippines 2020-04-30 2021-05-31 NCT04364815, RGAO-2020-0339 Phase 3 Clinical Not yet recruiting 1 13 Months 960 Belen L Dofitas, MD 2020-04-30
COVID-19 Seremban 3MCO Coronavirus disease 19 infection Pejabat Kesihatan Daerah Seremban Malaysia 2020-04-29 2020-09-01 54671, NMRR-20-786-54671 Phase Not Applicable Recruiting 1 4 Months Dr MOHD 'AMMAR IHSAN BIN AHMAD ZAMZURI 2020-05-01
COVID-T: COVID-19 Search in Conjunctival Cells Coronavirus disease 19 infection, Lung disease computed tomography alone, conjunctival swab alone, nasopharyngeal swab alone, real time-PCR alone, x-ray alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Policlinico Universitario Agostino Gemelli Italy 2020-03-26 2020-05-30 0013008/20, COVID-T, NCT04364594 Phase Not Applicable No longer recruiting 1 2 Months 50 2020-04-30
SCOPe: To Study the Clinical characteristics and treatment Outcome of COVID-19 Patients admitted in hospitals of Max Healthcare Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Super Speciality Hospital India 2020-04-25 CTRI/2020/04/024859, SCOPe Phase Not Applicable Not yet recruiting 1 1000 Dr Ram Shankar Mishra, Dr Sandeep Budhiraja, Rajesh Saxena 2020-04-29
PRON-COVID: The Prone Position in Covid-19 Affected Patients Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia continuous positive airway pressure therapy alone, oxygen therapy alone, prone positioning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University of Milano-Bicocca Italy 2020-03-20 2020-05-31 NCT04365959, PRON-COVID, PRON-COVID Phase Not Applicable No longer recruiting 1 2 Months 56 Giuseppe Foti, Prof. 2020-05-01
To study the effectiveness of Ivermectin with standard of care treatment versus standard of care treatment for COVID-19 cases. A Pilot Study Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Max Super Speciality Hospital India 2020-04-25 CTRI/2020/04/024858 Phase 2 Clinical Not yet recruiting 1 50 Dr Ram Shankar Mishra, Dr Sandeep Budhiraja, Rajesh Saxena 2020-04-29
Bid data analytic COVID-19 Coronavirus disease 19 infection predictive visual analytic method alone National Institutes of Health Malaysia Malaysia 2020-04-30 2020-08-31 54648, NMRR-20-790-54648 Phase Not Applicable Not yet recruiting 1 4 Months Dr Mohd Azahadi Omar, Encik MOHAMAD FUAD BIN MOHAMAD ANUAR 2020-04-29
RNA-based vaccine for COVID-19 Coronavirus disease 19 infection RNA-based vaccine alone Institute For Medical Research (Inc In Malaysia) Malaysia 2020-06-01 2022-12-31 54569, NMRR-20-764-54569 Phase Not Applicable Status not specified 1 31 Months Dr MASITA BINTI ARIP, Ms Ching Yee Ming 2020-04-30
COVID-19 NGS: NGS Diagnostic in COVID-19 Hosts: Genetic Cause Relating to the Course of Disease Progression Coronavirus disease 19 infection DNA methylation analysis alone, T-cell receptor repertoire sequencing alone, methylation beadchip (EPIC) array alone, next generation sequencing alone, whole genome sequencing alone, whole transcriptome sequencing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Tubingen Germany 2020-04-30 2021-08-31 COVID-19 NGS, COVID-19 NGS, NCT04364828 Phase Not Applicable Not yet recruiting 1 16 Months 1000 Michael Bitzer, Prof. Dr., Olaf Rieß, Prof. Dr. 2020-04-29
COVID-19: investigation into biochemical and hematological parameters in clinical laboratory Coronavirus disease 19 infection UNIVERSITI INDUSTRI SELANGOR (UNISEL) - SHAH ALAM CAMPUS Malaysia 2020-04-29 2020-05-29 54641, NMRR-20-760-54641 Phase Not Applicable Status not specified 1 1 Month CHIA ZHEN ZHAN 2020-04-29
Lung Recruitment Device for COVID-19 Coronavirus disease 19 infection Chest physiotherapy alone Dymedso Inc, Fonds de la Recherche en Sante du Quebec 2020-05-01 2020-12-31 MP-21-2020-2871, NCT04361435 Phase Not Applicable Not yet recruiting 0 8 Months 50 Atsushi Kawaguchi, MD PhD, Philippe Jouvet, MD PhD MBA, Saly Salti, MSc 2020-04-30
LAPTRANSCOV: Assessment of the Presence of the SARS-COV-2 Virus in the Peritoneum of COVID-19 Patients Coronavirus disease 19 infection RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier René-Dubos France 2020-05-31 2020-10-31 CHRD 0420, LAPTRANSCOV, NCT04361396 Phase Not Applicable Recruiting 2 5 Months 40 Christophe Poncelet, Maryline Delattre, Nelson Trelles, Veronique Da Costa 2020-05-01
Loneliness During the NPIs for the COVID-19 Pandemic in Norway: Risk Factors and Associations With Psychopathology Anxiety disorder, Coronavirus disease 19 infection, Depression, Psychiatric disorder non-pharmacological intervention treatment alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Modum Bad University of Oslo Norway 2020-03-31 2020-04-07 NCT04365881, REK12345 Phase Not Applicable Completed 1 10084 Asle Hoffart, PhD, Omid V. E. Ebrahimi, Cand Psychol, Sverre Urnes Johnson, PhD 2020-05-01
NutriCovid30: Nutritional Evaluation for Covid-19 Infection at D30 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Grenoble Universite Grenoble Alpes France 2020-05-31 2020-10-31 2020-A01120-39, NCT04365816, NutriCovid30 Phase Not Applicable Not yet recruiting 1 5 Months 600 Marie-France VAILLANT, PhD 2020-05-01
AIC: Azithromycin in Hospitalized COVID-19 Patients Coronavirus disease 19 infection azithromycin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-04-20 2020-05-05 AIC, AZITHROMYCIN IN COVID-19, NCT04359316 Phase 4 Clinical Not yet recruiting 1 40 Mehran Lack, MD, Mohammad Fathi, MD, Nader Markazi, MD, Nasser Malekpour Alamdari, MD, Sanaz Zargar Balaye Jam, MD, Sasan Tavana, MD, Seyed Sina Naghibi Irvani, MD, MPH, MBA 2020-04-29
An International, multicenter clinical study to evaluate the efficacy and safety of Polyoxidonium in hospitalized COVID-19 patients Coronavirus disease 19 infection Polyoxidonium alone NPO Petrovax Pharm LLC Russian Federation Phase Not Applicable Not yet recruiting 1 2020-04-29
CYNK001COVID: Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 Coronavirus disease 19 infection, Lower respiratory tract infection CYNK-001 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Celularity Inc, Sorrento Therapeutics Inc Infectious Disease Research Institute, Lung Biotechnology Inc US 2020-04-30 2021-11-30 CYNK-001-COVID-19, CYNK001COVID, NCT04365101 Phase 1/Phase 2 Clinical Not yet recruiting 0 19 Months 86 Corey Casper, MD MPH, Erica Rave, MS, IDRI 2020-04-29
OzonoCOVID19: Indirect Endovenous Systemic Ozone for New Coronavirus Disease (COVID 19) in Non-intubated Patients Coronavirus disease 19 infection Base WHO recommended treatment. alone, Systemic indirect endovenous ozone therapy alone, ozone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidad Católica San Antonio de Murcia Sociedad Española de Ozonoterapia Spain 2020-04-30 2020-06-30 NCT04359303, OzonoCOVID19, P.INV. OZONO-COVID19 VER.1.2 Phase 3 Clinical Not yet recruiting 1 2 Months 50 Francisco J Hidalgo Tallón, MD, PhD, Jose Baeza Noci, MD, PhD 2020-04-30
COVIDHIV: Clinical Characterization Protocol for COVID-19 in People Living With HIV Coronavirus disease 19 infection, HIV infection auto-questionnaires alone, biological collection alone, qualitative interviews alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-04-30 2020-10-31 2020-A00984-35, COVIDHIV, NCT04361604 Phase Not Applicable Not yet recruiting 1 6 Months 270 Antoine Chéret, Dr 2020-04-29
A Single-center, Retrospective Study to Find Prediction Factors Related to Mortality of COVID-19 Patients Coronavirus disease 19 infection, Diabetes mellitus, Viral pneumonia multivariate analysis alone, real-time RT-PCR test alone, univariate analysis alone Tongji Hospital China 2020-02-02 2020-04-01 NCT04365634, TJ20200202 Phase Not Applicable Completed 1 2 Months 306 Meifang Han, Professor, Qin Ning 2020-05-02
Metabolon Study to Provide Better Understanding of COVID-19 Coronavirus disease 19 infection Institute For Systems Biology, Metabolon Inc US Phase Not Applicable Status not specified 0 James R. Heath, Ph.D, Jason Goldman, M.D 2020-04-29
HASCOPT: Hydroxychloroquine Azithromycin COVID-19 Pregnancy Trial Coronavirus disease 19 infection, Respiratory failure azithromycin plus hydroxychloroquine Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital St. Joseph, Marseille, France France 2020-04-30 2021-01-31 HASCOPT, HASCOPT2020, NCT04365231 Phase 3 Clinical Not yet recruiting 1 9 Months 50 Laurence CUREL, Maria mg Gackiere, Raoul RD Desbriere, MD, Xavier-Côme xcd Donato 2020-04-29
Effect of RBT-9 on Preventing Progression of COVID-19 in High-Risk Individuals Coronavirus disease 19 infection RBT-9 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Renibus Therapeutics Inc 2020-06-01 2021-12-31 NCT04364763, REN-005 Phase 2 Clinical Not yet recruiting 0 19 Months 252 2020-04-29
A study to assess the efficacy of tocilizumab in severe patients with Corona Virus Disease19 (COVID-19) Coronavirus disease 19 infection routine therapy alone, tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator 2nd People's Hospital of Fuyang City, Anhui Provincial Hospital China National Center For Biotechnology Development, Department of Science and Technology of Anhui Province China Phase Not Applicable Status not specified 2 21 2020-04-29
COVID-RPC: Observational, Cohort of COVID-19 Patients at Raymond-Poincare Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-04-30 2020-05-31 20SBS-COVID-RPC, COVID-RPC, NCT04364698 Phase Not Applicable Not yet recruiting 1 1 Month 500 Aurelien Dinh, MD, Simon Bessis, MD 2020-04-29
Convalescent Plasma for COVID-19 Coronavirus disease 19 infection, Viral pneumonia convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ente Ospedaliero Cantonale, Switzerland 2020-04-27 2020-06-30 2020-00895, NCT04365439 Phase 2 Clinical Not yet recruiting 2 2 Months 10 Beatrice Bernasconi, Enos Bernasconi, Enos Bernasconi, M.D., Stefano Fontana, M.D. 2020-04-29
Covid-19 Associated Coagulopathy Blood clotting disorder, Coronavirus disease 19 infection enoxaparin sodium alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Iowa US 2020-04-16 2021-04-16 202004235, NCT04360824 Phase 4 Clinical Not yet recruiting 0 12 Months 170 Usha Perepu 2020-04-29
Clinical Trial to Evaluate the Efficacy of Treatment With Hyperimmune Plasma Obtained From Convalescent Antibodies of COVID-19 Infection Coronavirus disease 19 infection convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Andalusian Network for Design and Translation of Advanced Therapies Spain 2020-04-30 2021-12-31 NCT04366245, PC/COVID-19 Phase 1/Phase 2 Clinical Recruiting 1 20 Months 72 Ana Cardesa Gil 2020-04-29
Proving the efficacy of Homeopathic treatment in prevention and cure of COVID-19 Coronavirus disease 19 infection Variable regimens including Ars Alb , Bryonia Alba , Camphora , Helleborus niger , Justicia Adhatoda Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Welling Healthcare Private Limited India 2020-05-04 CTRI/2020/04/024857 Phase 1/Phase 2 Clinical Not yet recruiting 1 100 Angelo Smith, Dr Sourabh R Welling 2020-04-29
HIGH-PRONE-COVID-19: Prone Position in Patients on High-flow Nasal Oxygen Therapy for COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia prone decubitus alone, usual care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Tours France 2020-04-27 2020-11-24 2020-A01121-38, DR200125, HIGH-PRONE-COVID-19, HIGH-PRONE-COVID-19, NCT04358939 Phase Not Applicable Recruiting 13 6 Months 248 Agathe DELBOVE, MD, Anne-Charlotte TELLIER, MD, Arnaud THILLE, MD-PhD, Christophe GUITTON, MD, Damien ROUX, MD-PhD, Erwan L'HER, MD-PhD, Gaetan PLANTEFEVE, MD, Guillaume VOIRIOT, MD, Jean DELLAMONICA, MD-PhD, Jean REIGNIER, MD-PhD, Mai-Anh NAY, MD, Saadalla NSEIR, MD, Stephan EHRMANN, MD-PhD, Yoanatan PEREZ, MD, Yonatan PEREZ, MD 2020-04-30
COVID-19 CAir: SARS-CoV-2 Associated Respiratory Failure Recovery Coronavirus disease 19 infection, Respiratory failure Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Zurich Switzerland 2020-05-31 2020-12-31 2020-00745, COVID-19 CAir, NCT04365595 Phase Not Applicable Recruiting 1 7 Months 200 Christian F Clarenbach, MD, Dario Kohlbrenner, MSc 2020-04-30
COP-COVID-19: Convalescent Plasma Compared to the Best Available Therapy for the Treatment of SARS-CoV-2 Pneumonia Coronavirus disease 19 infection, Viral pneumonia convalescent plasma alone, supportive management alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario Dr. Jose E. Gonzalez Mexico 2020-04-27 2021-05-30 COP-COVID-19, IF20-00002, NCT04358783 Phase 2 Clinical Not yet recruiting 1 13 Months 30 Adrian Camacho-Ortiz, MD, Eduardo Pérez Alba, MD, Laura Marina Nuzzolo Shihadeh, MD 2020-04-30
COVID-19 (Coronavirus Disease 2019) Intubation Barrier Box, Randomized, Controlled Trial Coronavirus disease 19 infection COVID-19 barrier box alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of British Columbia Canada 2020-05-31 2021-04-30 H20-01270, NCT04366141 Phase Not Applicable Not yet recruiting 1 11 Months 120 Anton Chau, MD, Tim Jen, MD 2020-04-30
A Proof of Concept study of Nu.Q COVID-19 Triage Test in COVID-19 patients Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia Volition’s Nu.QTM nucleosome assays alone VolitionRX Ltd Phase Not Applicable Planned 0 2020-04-29
JAKINKOV: Efficacy of Intravenous Anakinra and Ruxolitinib During COVID-19 Inflammation Coronavirus disease 19 infection, Inflammatory disease, Respiratory distress syndrome, Viral pneumonia anakinra alone, Jakavi plus Kineret Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer Assistance Publique Hopitaux De Marseille France 2020-05-01 2020-08-31 2020-001963-10, 2020-CHITS-003, JAKINKOV, NCT04366232 Phase 2 Clinical Not yet recruiting 3 4 Months 50 David DELARBRE, MD, Gilles HITTINGER, MD, Gilles KAPLANSKI, MD, Jean-Philippe Suppini, PhD 2020-04-30
A study to track coronavirus (COVID-19) in the general population Coronavirus disease 19 infection University of Oxford UK Phase Not Applicable Status not specified 1 300000 Department for Health and Social Care, Office for National Statistics 2020-04-29
ESCAPE: Study to evaluate the efficacy and tolerability of treatment with vafidemstat in combination with standard of care treatment to prevent Acute Respiratory Distress Syndrome in adult severely ill patients with COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome standard of care treatment alone, vafidemstat alone Lysine specific histone demethylase 1 inhibitor, MAO B inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Oryzon Genomics SA Spain 2020-04-24 2020-001618-39, CL08-ORY-2001_COVID-19, ESCAPE Phase 2 Clinical No longer recruiting 1 40 Sonia Gutiérrez 2020-04-30
AUTONOMIC: Stress Biomarkers Leading to Professional Burnout Among People Involved in a Mobile Intensive Care Unit During the COVID-19 Pandemic Anxiety disorder, Coronavirus disease 19 infection, Post traumatic stress disorder electrocardiography alone, electrodermal test alone, emotional stimulation test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Direction Centrale du Service de Sante des Armees Institut de Recherche Biomedicale des Armees France 2020-04-30 2020-06-30 2020-COVID19-11, AUTONOMIC, NCT04365335 Phase Not Applicable Not yet recruiting 1 2 Months 60 Damien CLAVERIE, MD, PhD 2020-04-30
SINK COVID-19: Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19 Coronavirus disease 19 infection Ketalar alone, naltrexone (once-monthly controlled-release, Medisorb), Alkermes alone, Ketalar plus naltrexone (once-monthly controlled-release, Medisorb), Alkermes Opioid receptor antagonist, Opioid receptor mu antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) William Beaumont Hospitals US 2020-04-30 2020-08-31 2020-097, NCT04365985, SINK COVID-19 Phase 2 Clinical Not yet recruiting 0 4 Months 500 Matthew Sims, MD, Matthew Sims, MD PhD, Maureen Cooney, RN, BSN 2020-04-30
Convalescent Plasma to Limit COVID-19 Complications in Hospitalized Patients Coronavirus disease 19 infection, Respiratory disease anti-SARS-CoV-2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Albert Einstein College of Medicine New York University US 2020-04-17 2023-04-30 2020-11467, NCT04364737 Phase 2 Clinical Recruiting 0 36 Months 300 Hyunah Yoon, MD, Liise-anne Pirofski, MD, Mila Ortigoza, MD 2020-04-30
COVIDIOL: Prevention and Treatment With Calcifediol of COVID-19 Induced Acute Respiratory Syndrome Coronavirus disease 19 infection Hidroferol alone, best available therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundación Para La Investigación Biomédica De Córdoba, Maimonides Biomedical Research Institute of Cordoba Consejeria de Salud. Junta de Andalucia, Dynamic Solutions Inc, FAES Farma SA Spain 2020-04-28 2020-08-28 2020-001717-20, COVIDIOL, COVIDIOL, NCT04366908 Phase 2 Clinical Not yet recruiting 1 4 Months 1008 Antonio Luque, Antonio Luque, MsC, José López Miranda, MD, José Manuel Quesada Gómez, MD 2020-05-01
MESCEL-COVID19: Clinical Trial of Allogeneic Mesenchymal Cells From Umbilical Cord Tissue in Patients With COVID-19 Coronavirus disease 19 infection umbilical cord tissue derived undifferentiated allogeneic mesenchymal cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Infantil Universitario Nino Jesus Apices Soluciones, S.L. Spain 2020-04-24 2021-05-31 2020-001450-22, MESCEL-COVID19, MESCEL-COVID19, NCT04366271 Phase 2 Clinical Not yet recruiting 6 13 Months 106 Clara I Rodriguez, MD, Francisco García-Rio, MD, Jose A Lorente Balanza, MD, Julio Ancochea, MD, Luis Madero, MD, Luis Madero, PhD, Maria J del Cerro Marin, MD, Mrs. Laura Aranzasti, Sergio Serrano, MD, Teresa de Rojas, PhD 2020-05-02
REMDECO-19: Multicenter, Retrospective Study of the Effects of Remdesivir in the Treatment of Severe Covid-19 Infections Coronavirus disease 19 infection remdesivir alone Coronavirus non structural protein 8 modulator, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-04-30 2020-05-31 APHP200522, NCT04365725, REMDECO-19 Phase Not Applicable Not yet recruiting 1 1 Month 200 Jeremie ZERBIT, PharmaD, Jérémie ZERBIT, PharmaD 2020-04-30
RAMIC: Ramipril for the Treatment of COVID-19 Coronavirus disease 19 infection ramipril alone ACE inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California San Diego Pfizer Inc US 2020-04-30 2021-04-30 NCT04366050, RAMIC, RAMIC TRIAL Phase 2 Clinical Not yet recruiting 0 12 Months 560 Archana Bhatt, Len Lazaro, Rohit Loomba 2020-05-02
Progesterone for the Treatment of COVID-19 in Hospitalized Men Coronavirus disease 19 infection progesterone (sc, in vitro fertlilization), Institut Biochimique alone, standard of care alone Progesterone receptor agonist Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cedars-Sinai Medical Center IBSA Institut Biochimique SA US 2020-04-27 2021-04-17 NCT04365127, STUDY00000611 Phase 1 Clinical Recruiting 0 11 Months 40 Sara Ghandehari, MD, Vanessa Vasco 2020-04-30
COVIDMES: Efficacy and safety evaluation of umbilical cord mesenchymal stem cells for the treatment of patients with respiratory failure due to coronavirus (COVID-19) Coronavirus disease 19 infection, Respiratory distress syndrome umbilical cord mesenchymal stem cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Banc De Sang I Teixits Spain 2020-04-23 2020-001505-22, BST-COVID-01, COVIDMES Phase 1/Phase 2 Clinical No longer recruiting 1 30 Banc de Sang i Teixits 2020-04-30
BIRCOV: ARB, ACEi, DRi in COVID-19 Coronavirus disease 19 infection, Hypertension angiotensin converting enzyme inhibitor (ACEi) therapy alone, angiotensin receptor blocker (ARB) therapy alone, dopamine reuptake inhibitor (DRI) therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical Practice Prof D. Ivanov Ukraine 2020-04-01 2021-08-01 BIRCOV, COVID20, NCT04364984 Phase Not Applicable Recruiting 1 16 Months 10 Dmytro Ivanov, MD, Prof, Mariia Ivanova, MD, PhD 2020-04-30
DURO-SIN: COVID-19 in an academic teaching hospital in Konstanz/Germany - evaluation of the 'double rule out - single rule in' concept Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Klinikum Konstanz, II. Medizin Germany 2020-04-27 81/2020, DRKS00021605, DURO-SIN, U1111-1251-0310 Phase Not Applicable Recruiting 1 200 Stephan Walterspacher 2020-04-30
Factors Associated With Clinical Outcomes in Patients Hospitalized for COVID-19 in GHT-93 Est Coronavirus disease 19 infection, Viral pneumonia corticosteroid therapy alone, systematic antibiotic therapy alone, Variable regimens including azithromycin , baricitinib , hydroxychloroquine , lopinavir + ritonavir , sarilumab , tocilizumab HIV protease inhibitor, IL-6 receptor antagonist, Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Centre Hospitalier Intercommunal Robert Ballanger Groupe Hospitalier Pitie-Salpetriere France 2020-03-14 2020-07-31 GHTRB-2020-01, NCT04366206 Phase Not Applicable Recruiting 2 4 Months 143 Benjamin Rossi, MD, Dr. Hélène GROS, Hélène Gros, MD, Lee S Nguyen, MD, PhDc 2020-04-30
Evaluating AVM-0703 for Treatment of COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome AVM-0703 plus hydrocortisone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AVM Biotechnology LLC Medpace Inc 2020-06-30 2023-06-30 AVM0703-101, NCT04366115 Phase 1/Phase 2 Clinical Not yet recruiting 0 36 Months 126 Brandon Franklin 2020-04-30
Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter, Cohort Study Coronavirus disease 19 infection, Viral pneumonia azithromycin alone, baricitinib alone, hydroxychloroquine alone, lopinavir + ritonavir alone, oseltamivir alone, remdesivir alone, sarilumab alone, tocilizumab alone Coronavirus non structural protein 8 modulator, Exo-alpha sialidase inhibitor, HIV protease inhibitor, IL-6 receptor antagonist, Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor, RNA polymerase modulator Groupe Hospitalier Pitie-Salpetriere CMC Ambroise Paré, Centre Hospitalier Intercommunal Montfermeil-Le Raincy, Centre Hospitalier Intercommunal Robert Ballanger France 2020-03-14 2020-12-31 CIC1421-20-06, NCT04365764 Phase Not Applicable Recruiting 2 9 Months 400 Anis Saib, MD, Hélène Gros, MD, Joe-Elie Salem, MD, PhD, Lee S Nguyen 2020-04-30
COV-CREM: Study of Specific Viral Immune Responses Induced by SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital of Besancon France 2020-04-20 2025-04-20 2020/502, COV-CREM, NCT04365322 Phase Not Applicable Recruiting 1 60 Months 60 Kevin BOUILLER, MD, Marie KROEMER, PharmD PhD 2020-04-30
CBP-COVID: Impact of SARS-COV2 Infection and Confinement on Diagnostic and Therapeutic Management of Lung Cancer: Ambispective Study Extended Over Two Time Periods Coronavirus disease 19 infection, Lung tumor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier le Mans ONCOPL (FR) 2020-06-30 2022-08-28 CBP-COVID, CHM-2020/S15/03, NCT04366219 Phase Not Applicable Not yet recruiting 0 25 Months 2000 CHRISTELLE JADEAU, OLIVIER MOLINIER, MD 2020-04-30
A larger phase IIb/III trial of recombinant subunit-trimer vaccine (COVID-19), Clover Biopharmaceuticals for the potential prevention of coronavirus infection COVID-19 caused by SARS-CoV-2 (2019-nCoV) Coronavirus disease 19 infection recombinant subunit-trimer vaccine (COVID-19), Clover Biopharmaceuticals alone Angiotensin converting enzyme 2 modulator Linear Clinical Research Limited Australia Phase 2/Phase 3 Clinical Planned 1 2020-04-30
The Psychological Impact of COVID-19 Outbreak on COVID-19 Survivors and Their Families Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of Hong Kong Queen Mary Hospital Hong Kong 2020-04-27 2021-06-30 NCT04365348, UW20-300 Phase Not Applicable Not yet recruiting 1 14 Months 300 Agnes YK Lai, PhD, Mary SM Ip, MD 2020-04-30
A phase I clinical trial of recombinant subunit-trimer vaccine (COVID-19) in healthy adult and healthy elderly trial participants Coronavirus disease 19 infection recombinant subunit-trimer vaccine (COVID-19), Clover Biopharmaceuticals alone Angiotensin converting enzyme 2 modulator Healthy volunteers accepted Clover Biopharmaceuticals AUS Pty Ltd, Coalition for Epidemic Preparedness Innovations, Linear Clinical Research Limited Australia Phase 1 Clinical Planned 1 2020-04-30
COVIPACT: Impact of the COVID-19 Infectious Epidemic on the Management of Oncology and Onco-hematology Patients and on the Psychological Consequences for Patients and Caregivers Acute stress disorder, Cognitive disorder, Coronavirus disease 19 infection, Hematological neoplasm, Post traumatic stress disorder, Sleep disorder, Solid tumor Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Francois Baclesse France 2020-04-15 2020-12-31 2020-A00879-30, COVIPACT, NCT04366154 Phase Not Applicable Recruiting 1 8 Months 385 Audrey FAVEYRIAL, MD, Florence JOLY, PhD 2020-05-01
OUTCOV: Outpatient Treatment of COVID-19 in Patients With Risk Factor for Poor Outcome Bordetella pertussis infection, Coronavirus disease 19 infection, Dyspnea azithromycin alone, hydroxychlororquine alone, lopinavir + ritonavir alone HIV protease inhibitor Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Groupe Hospitalier Paris Saint-Joseph France 2020-04-28 2021-01-28 NCT04365582, OUTCOV, OUTCOV Phase 3 Clinical Not yet recruiting 5 9 Months 640 Christos CHOUAID, MD, Helene Beaussier, MD PhD, Hilario Nunes, MD, Jean Marc NACCACHE, MD, Jean-Marc Naccache, MD, Pierre CHARLES, MD 2020-04-30
Evaluation of the Probiotic Lactobacillus Coryniformis K8 on COVID-19 Prevention in Healthcare Workers Coronavirus disease 19 infection Lactobacillus coryniformis K8 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Puleva Biotech SA Spain 2020-04-24 2020-10-31 NCT04366180, P054 Phase Not Applicable Recruiting 1 6 Months 314 Raquel Rodriguez Blanque 2020-05-01
COVIDGHPSJCite: Become of Patients Infected or Suspected of Being Infected by Covid-19 and Supported by the GHPSJ and the Establishments of the Paris Plaisance Hospital City Coronavirus disease 19 infection Groupe Hospitalier Paris Saint-Joseph France 2020-04-01 2022-12-31 COHORTE COVID GHPSJ CITEH, COVIDGHPSJCite, NCT04365530 Phase Not Applicable Recruiting 5 33 Months 2000 Benoit PILMIS, MD, Bernard DURAND GASSELIN, MD, Bernard Durand Gasselin, MD, Florence Bonte, MD, Helene BEAUSSIER, PharmD, pHD, Maxime TOUZOT, MD, Sebastien HASCOET, MD, Sebastien Hascoet, MD 2020-04-30
Canakinumab to Reduce Deterioration of Cardiac and Respiratory Function Due to COVID-19 Coronavirus disease 19 infection, Heart injury, Inflammatory disease, Respiratory failure canakinumab alone Immunoglobulin G1 agonist, Interleukin-1 beta ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cleveland Clinic Foundation US 2020-04-24 2020-12-31 IND 149328, NCT04365153 Phase 2 Clinical Recruiting 0 8 Months 45 Calvin Sheng, M. D., Ossama Abou Hassan, M. D., Paul C Cremer, M. D., Sidhharth Dugar, M. D., Tom Wang, M. D., Venu Menon, M. D., Yuki Kuramochci, RN BSN, Yuki Kuramochi, RN BSN 2020-04-29
CardiacCovid: Patient Recovery From Heart Surgery During the Covid-19 Pandemic Cardiac surgical procedure, Coronavirus disease 19 infection, Depression Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Barts and The London NHS Trust Queen Mary University of London UK 2020-04-18 2021-12-31 132127, CardiacCovid, NCT04366167 Phase Not Applicable Recruiting 1 20 Months 100 Aung Ye Oo, MD, Julie Sanders, PhD, Teofila Bueser, MSc 2020-04-29
A Novel Nomogram to Predict Severity of COVID-19 Coronavirus disease 19 infection RT-PCR test alone, computed tomography imaging alone, novel nomogram model prediction alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Xinqiao Hospital of Chongqing China 2020-01-17 2021-12-31 NCT04366024, XQONC-016 Phase Not Applicable Recruiting 1 23 Months 1000 Jianguo Sun, Sun Jianguo 2020-04-29
A phase II, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of OT-101 in adult patients hospitalized with COVID-19 and pneumonia Coronavirus disease 19 infection, Viral pneumonia OT-101 alone Factor IX agonist Mateon Therapeutics Inc US Phase 2 Clinical Planned 0 2020-04-29
PRE-VENT: A phase III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and efficacy of pacritinib plus standard of care versus placebo plus standard of care in hospitalized patients with severe COVID-19, including patients with and without cancer Coronavirus disease 19 infection pacritinib alone, standard of care alone CSF-1 antagonist, Cytochrome P450 reductase inhibitor, Flt3 tyrosine kinase inhibitor, IRAK-1 protein kinase inhibitor, Jak2 tyrosine kinase inhibitor CTI BioPharma Corp US 2020-04-27 PRE-VENT Phase 3 Clinical Not yet recruiting 0 358 John Mascarenhas 2020-04-29
REACOVIM: Study of Clinical and Immune Severity Profiles of Patients Infected With SARS-Cov2 (COVID-19) Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Direction Centrale du Service de Sante des Armees France 2020-04-20 2022-04-20 2020-COVID19-05, NCT04365166, REACOVIM Phase Not Applicable Not yet recruiting 2 24 Months 100 Clément DUBOST, MD, PhD, Nicolas LIBERT, MD, PhD 2020-04-30
Cardiovascular Effects of COVID-19 Cardiovascular disease, Coronavirus disease 19 infection fluoxetine (Zydis, tablet, autism), Autism Therapeutics alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) NYU Langone Health US 2020-04-08 2020-12-31 20-00416, NCT04365699 Phase 2 Clinical Recruiting 0 8 Months 500 Stuart Katz, MD 2020-04-30
PIIPPI: COVID-19: Povidone-Iodine Intranasal Prophylaxis in Front-line Healthcare Personnel and Inpatients Coronavirus disease 19 infection Standard PPE alone, Standard care alone, povidone-iodine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Kentucky US 2020-05-31 2021-05-31 58748, NCT04364802, PIIPPI Phase 2 Clinical Not yet recruiting 0 12 Months 250 Alexandra E Kejner, MD, James Porterfield, MD, PhD, Melissa Thompson-Bastin, PharmD, Nikita Gupta, MD, Nikta Gupta, MD 2020-04-30
PEAC: Protective Effect of Aspirin on COVID-19 Patients Coronavirus disease 19 infection, Viral pneumonia aspirin alone, combined standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Xijing Hospital China 2020-02-10 2020-06-30 NCT04365309, PEAC, XI JINGH Phase 2/Phase 3 Clinical Recruiting 1 4 Months 128 Cai Yue 2020-04-30
The Psychological Impact of the COVID-19 on Students Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of Hong Kong Hong Kong 2020-04-26 2021-03-31 NCT04365361, UW20-298 Phase Not Applicable Not yet recruiting 1 11 Months 300 Agnes YK Lai, PhD, Kelvin MP Wang, PhD, LAI YK Agnes, PhD 2020-04-30
A phase III trial to evaluate NT-300 for the early treatment of COVID-19 and other viral respiratory illnesses Coronavirus disease 19 infection, Viral respiratory tract infection nitazoxanide (controlled-release, viral infections), Romark alone Romark Laboratories LC Phase 3 Clinical Planned 0 2020-04-29
Validation of new detection methods for SARS CoV-2 in suspected COVID-19 Coronavirus disease 19 infection Naso-pharyngeal swab testing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Constance Deutsche Forschungsgemeinschaft (DFG), German Federal Ministry of Education and Research Germany 2020-04-24 DRKS00021578, Eilentscheid 05/2020, U0351-4483-4510 Phase 1 Clinical Recruiting 1 300 Christof Hauck, Marcus Schuchmann 2020-05-01
A clinical study of POL-6014 in the treatment of patients with COVID-related acute respiratory distress syndrome Coronavirus disease 19 infection, Respiratory distress syndrome lonodelestat alone Leukocyte elastase inhibitor Santhera Pharmaceuticals AG Cold Spring Harbor Laboratory Phase Not Applicable Planned 0 2020-04-29
PREVENT-COVID Trial: Prazosin to Prevent COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory tract infection once daily prazosin (OROS), ALZA alone Alpha 1A adrenoceptor antagonist, Cyclic nucleotide phosphodiesterase inhibitor Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Johns Hopkins University US 2020-04-30 2020-12-31 COV2001, IRB00246659, NCT04365257, PREVENT-COVID Trial Phase 2 Clinical Not yet recruiting 0 8 Months 220 Chetan Bettegowda, MD/PhD 2020-04-30
Mon-Covid: Home Care for Patients With COVID-19: Active Monitoring in Two Italian Health Units (Casale Monferrato and Torino) Coronavirus disease 19 infection home care monitoring alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mario Negri Gynecologic Oncology group Italy 2020-04-21 2020-12-31 MON-COVID, Mon-Covid, NCT04361916 Phase Not Applicable Recruiting 1 8 Months 425 Chiara Gerardi, PhD, Guido Bertolini, MD, Rita Banzi, PhD, Roberto Stura 2020-04-30
Use of Contemporary Live Tele-Video Conferencing for Continuing Surgical Training at the time of COVID-19 pandemic Coronavirus disease 19 infection Sultanah Aminah Hospital Malaysia 2020-05-01 2020-05-31 NMRR-20-814-54742 Phase Not Applicable Status not specified 1 1 Month dr henry tan chor lip 2020-04-30
Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients With Severe Pneumonia Due to COVID-19 Coronavirus disease 19 infection, Viral pneumonia allogeneic and expanded adipose tissue-derived mesenchymal stem cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Andalusian Network for Design and Translation of Advanced Therapies Junta De Andalucia Spain 2020-04-30 2021-10-31 2020-001364-29, ADIQURE/COVID-19, NCT04366323 Phase 1/Phase 2 Clinical Not yet recruiting 1 18 Months 26 Ana Cardesa Gil, Clinical Trial Unit 2020-04-30
Stress Level Among Healthcare Workers in Handling COVID-19 Patients in Sarawak General Hospital Coronavirus disease 19 infection Universiti Malaysia Sarawak Malaysia 2020-05-04 2020-10-30 54744, NMRR-20-819-54744 Phase Not Applicable Not yet recruiting 1 5 Months Dr. Sim Sze Kiat 2020-04-30
CancerMCO: CancerMCO Coronavirus disease 19 infection Universiti Putra Malaysia Malaysia 2020-05-01 2020-11-01 54786, CancerMCO, NMRR-20-825-54786 Phase Not Applicable Not yet recruiting 1 6 Months Dr Sri Ganesh Muthiah 2020-04-30
CT-COVID-AI: CT-COVID-AI Coronavirus disease 19 infection Chest CT Diagnosis alone Hospital Sungai Buloh Malaysia 2020-05-01 2020-11-02 54784, CT-COVID-AI, NMRR-20-826-54784 Phase Not Applicable Not yet recruiting 1 6 Months Dr Mohan Dass Pathmanathan 2020-04-30
Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia Coronavirus disease 19 infection Standard treatment alone, hydroxychloroquine alone, Variable regimens including azithromycin , hydroxychloroquine , lopinavir + ritonavir HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National University of Colombia Fundación Cardioinfantil-Instituto De Cardiología, Hospital Universitario Reina Sofia, Hospital Universitario San Ignacio, Hospital Universitario de Neiva, Javeriana University Colombia 2020-05-11 2020-10-31 76968, NCT04359095 Phase 2/Phase 3 Clinical Not yet recruiting 6 5 Months 1600 Angel García-Peña, MD, Carlos A Alvarez-Moreno, MD, MSc, PhD, Dagoberto Santofimio-Sierra, MD, Hernando G Gaitán-Duarte, MD, MSc, Hernando Gaitán, MD, Jose G Ruiz-Rodriguez, MD, Juan Villar-Centeno, Nancy Yomayusa-Gonzalez, MD 2020-05-01
Needle Stick Injuries in Emergency Medical Service Practice Coronavirus disease 19 infection Cardiopulmonary resuscitation alone, double gloves alone Lazarski University Medical University of Bialystok, Poznan University of Medical Sciences Poland 2020-02-28 2020-04-24 NCT04363788, OH_PPE_1 Phase Not Applicable Completed 1 1 Month 300 2020-04-30
DISTANSE COVID: Direct Income SupporT and Advice Negating Spread of Epidemic COVID-19: a Randomized, Controlled Trial Coronavirus disease 19 infection Cash transfer alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Michaels Hospital Canada 2020-04-20 2021-06-30 20-081, DISTANSE COVID, NCT04359264 Phase Not Applicable Not yet recruiting 2 14 Months 392 Mike Bedard, Mike Bedard, MD, Nav Persaud, Nav Persaud, MD, MSc 2020-04-30
Adapting the Decathlon Group Easybreathe snorkelling face mask for the safer administration of oxygen and/or continuous positive airway pressure and in the intra/interhospital transportation of patients with proven or suspected COVID 19 infection Coronavirus disease 19 infection Easybreathe snorkelling face mask alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Monash Health Australia 2020-04-27 2020-10-27 ACTRN12620000472976p Phase Not Applicable Not yet recruiting 1 6 Months 100 Dr Simon Joosten 2020-05-01
COVID-19 Recovered Volunteer Research Participant Pool Registry Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California Los Angeles US 2020-04-08 2042-04-20 20-000625, NCT04359602 Phase Not Applicable Recruiting 0 264 Months 10000 Antonia Petruse, MBA, Arash Naeim, MD, PhD 2020-04-30
Different PEEP Settings of COVID-19 Induced ARDS Coronavirus disease 19 infection, Respiratory distress syndrome ARDSnet table PEEP setting alone, Optimizing compliance alone, Optimizing oxygenation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Southeast University China 2020-03-05 2020-03-25 COVID-19 PEEP TITRATION, NCT04359251 Phase Not Applicable Completed 1 20 Chun C Pan, Chun Pan 2020-04-30
STRIPE-3: Study for Testing and Reviewing Improvised PPE Effectiveness 3 Coronavirus disease 19 infection Anesthetic facemask based improvised personal protective equipment alone, Snorkel-based improvised personal protective equipment alone, light exercise alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Guy's & St Thomas' Hospital NHS Trust UK 2020-04-28 2020-10-28 NCT04362163, STRIPE-3, TAP_PRG_21_04_2020_2 Phase Not Applicable Not yet recruiting 1 6 Months 10 Paul R Greig, MBChB 2020-05-01
REST: Online Cognitive Behavioral Therapy (CBT) for Stress Disorders in Health Workers Involved in the Care of Patients During the Covid-19 Epidemic Acute stress disorder, Coronavirus disease 19 infection Online cognitive behavioral therapy (CBT) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University Hospital of Strasbourg 2020-05-01 2021-10-01 7799, NCT04362358, REST Phase Not Applicable Not yet recruiting 0 17 Months 120 Luisa Weiner, MD 2020-04-30
TVP-COVID-RIV: Influence of COVID-19 Infection in Thromboembolic Venous Disease: National Cohort Study Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sociedad Espanola de Angiologia y Cirugia Vascular Spain 2020-04-30 2020-12-31 NCT04361981, RIV-R3, TVP-COVID-RIV Phase Not Applicable Not yet recruiting 1 8 Months 50 Joaquin De Haro, MD 2020-04-30
Liver Injury in Patients With COVID-19 Coronavirus disease 19 infection, Liver injury Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidad Austral De Argentina Argentina 2020-04-15 2020-12-31 CIE N° P 20-011, NCT04358380 Phase Not Applicable Recruiting 1 8 Months 34 Marcelo O Silva, MD 2020-04-30
DAWN AZITHRO: COVID-19: A randomized, open-label, adaptive, proof-of-concept clinical trial of new antiviral drug candidates against SARS-CoV-2 Coronavirus disease 19 infection azithromycin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) UZ Leuven-University Hospitals Belgium 2020-04-22 2020-001614-38, DAWN AZITHRO, S63935 Phase 2 Clinical Recruiting 1 240 Clinical trial center UZ Leuven, clinical trial center UZ Leuven 2020-04-30
COVID19 HTAA: COVID19 HTAA Coronavirus disease 19 infection Hospital Tengku Ampuan Afzan Malaysia 2020-04-25 2020-07-31 54513, COVID19 HTAA, NMRR-20-811-54513 Phase Not Applicable Status not specified 1 3 Months 90 Dr SOH TZE VEE 2020-04-30
The epidemiology of COVID-19 cases and disease surveillance system in Hulu Langat district, Selangor Coronavirus disease 19 infection Pejabat Kesihatan Daerah Hulu Langat Malaysia 2020-04-24 2021-04-23 54757, NMRR-20-809-54757 Phase Not Applicable Status not specified 1 12 Months Dr WAN MING KEONG 2020-04-30
MLCOVID: MLCOVID Coronavirus disease 19 infection Machine Learning alone Institute For Medical Research (Inc In Malaysia) Malaysia 2020-04-24 2021-04-23 54483, COVID19-HSB/2, MLCOVID, NMRR-20-807-54483 Phase Not Applicable Status not specified 1 12 Months Dr Suresh Kumar, Dr WONG XIN CI 2020-04-30
QTc COVID: QTc COVID Coronavirus disease 19 infection Hospital Sungai Buloh Malaysia 2020-04-30 2020-05-30 54728, NMRR-20-798-54728, QTc COVID Phase Not Applicable Status not specified 1 1 Month Ms KOH HUI MOON 2020-04-30
IP COVID-19: IP COVID-19 Coronavirus disease 19 infection National Institutes of Health Malaysia Malaysia 2020-04-30 2020-09-30 54770, IP COVID-19, NMRR-20-793-54770 Phase Not Applicable Status not specified 1 5 Months Dr. Ainul Nadziha bt. Mohd. Hanafiah, Roslinda binti Abu Sapian 2020-04-30
Study of FT-516 for the Treatment of COVID-19 in Hospitalized Patients With Hypoxia Coronavirus disease 19 infection, Hypoxia FT-516 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Masonic Cancer Center US 2020-05-04 2022-01-31 IDIM-2020-28708, NCT04363346 Phase 1 Clinical Not yet recruiting 0 20 Months 12 Dr.Joshua Rhein, MD, Mahsa Abassi, DO,MPH, Meghan Rothenberger, MD, Timothy Schacker, MD 2020-05-01
COVID AMBU 60: Multicenter, Observational Study on Management COVID-19 Positive Outpatients in a French Cluster Coronavirus disease 19 infection observational management alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Maison de Sante Pluridisciplinaire de Creil France 2020-03-01 2020-12-31 2020-A01059-30, COVID AMBU 60, NCT04363099 Phase Not Applicable Recruiting 1 10 Months 1000 DIMI Svetlane, Svetlane DIMI, Svetlane DIMI, M.D 2020-04-30
COVID-EC Study: Clinical Characteristics of Patients With COVID-19 in Guayaquil, Ecuador Coronavirus disease 19 infection, Respiratory tract infection azithromycin alone, chloroquine alone, corticosteroids alone, enoxaparin alone, heparin alone, hydroxychloroquine alone, ivermectin alone, lopinavir + ritonavir alone, nitazoxanide alone, oseltamivir alone, tocilizumab alone Chloride channel modulator, Exo-alpha sialidase inhibitor, HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinico San Carlos Universidad Catolica Santiago de Guayaquil Spain 2020-04-30 2020-05-31 001, COVID-EC Study, NCT04362969 Phase Not Applicable Not yet recruiting 1 1 Month 300 Jorge Carriel M. 2020-05-01
Collection of Biological Samples With Clinical Characterization of Covid-19 Patients Coronavirus disease 19 infection blood sampling alone Centre Hospitalier Intercommunal Creteil France 2020-05-01 2020-12-01 COVIGENET, NCT04363385 Phase Not Applicable Not yet recruiting 1 7 Months 500 Bernard MAITRE, Ph D, Bernard Maitre, Ph D, Isabelle HAU, MD 2020-04-29
Rhu-pGSN for Severe Covid-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia gelsolin, BioAegis Therapeutics alone Actin antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) BioAegis Therapeutics Inc 2020-06-30 2020-09-30 BTI-202, NCT04358406 Phase 2 Clinical Not yet recruiting 0 3 Months 60 Mark J DiNubile, MD, Susan L Levinson, PhD 2020-05-01
CEDiD: COVID-19 Early Diagnosis in Doctors Coronavirus disease 19 infection Empatica E4 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) King's College London Empatica Srl UK 2020-04-27 2020-05-27 CEDID STUDY STH, CEDiD, NCT04363489 Phase Not Applicable Not yet recruiting 1 1 Month 30 Alexander Zargaran, Anne Greenough, Dina Radenkovic, Dina Radenkovic, MBBS, BSc, Dr Alexander Zargaran 2020-04-29
Levamisole and Isoprinosine in Immune-prophylaxis of Egyptian Healthcare Workers Facing COVID-19 Coronavirus disease 19 infection isoprinosine alone, levamisole alone, isoprinosine plus levamisole Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ain Shams University Egypt 2020-04-20 2020-12-01 FMASU P20A/ 2020, NCT04360122 Phase 3 Clinical Not yet recruiting 1 7 Months 100 Fatma Soliman E Ebeid 2020-04-30
The Effects of Pulmonary Physiotherapy Treatments on Patients With COVID-19 Coronavirus disease 19 infection, Viral pneumonia pulmonary physiotherapy techniques alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Tehran University of Medical Sciences Iran 2020-04-20 2020-08-01 99-1-103-47429, NCT04357340 Phase Not Applicable Not yet recruiting 1 3 Months 40 Behrouz Attarbashi Moghaddam, Ph.D., Mohammad Javaherian, Ph.D. cand., Seyyed Reza Raees Karami, MD., Zahra Ahmadinejad, MD. 2020-04-30
CovImmune: Study of Immune Response During SARS-CoV-2 Infection - (COVID-19) Coronavirus disease 19 infection blood sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Nice France 2020-04-22 2020-10-22 20-PP-05, CovImmune, NCT04355351 Phase Not Applicable Not yet recruiting 3 6 Months 400 Barbara SEITZ-POLSKI, MCUPH, Jean DELLAMONICA, PUPH, Matteo VASSALLO, PH, elisa DEMONCHY, PH, johanna PLANCHARD, PH, sonia BOYER-SUAVET, PH 2020-04-30
Convalescent Plasma Trial in COVID-19 Patients Coronavirus disease 19 infection, Hypoxia, Viral pneumonia convalescent plasma alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Royal College of Surgeons in Ireland - Medical University of Bahrain Bahrain Defence Force Royal Medical Services, Military Hospital, Salmaniya Medical Complex Bahrain 2020-04-19 2020-06-30 BDF/R&REC/2020-423, NCT04356534 Phase 2 Clinical Not yet recruiting 1 2 Months 40 Abdulkarim Abdulrahman, Dr., Abdulrahman Almadani, Dr., Amal Hejab, Dr., Manaf Al Qahtani, Dr., Manal Al Sayed, Dr., Pearl Wasif, MSc., Salman Yousif Alali, Dr., Sameer Otoom, Prof., Stephen Atkin, Prof. 2020-04-30
Nancy-CovH-AKI: Cardiovascular and Renal Biomarkers to Predict Acute Heart or Kidney Injury in Severe COVID-19 Infection Coronavirus disease 19 infection, Heart injury, Renal injury biological samples specific to research alone, clinical examination alone, telephone follow-up alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France France 2020-04-27 2020-10-18 2020PI072, NCT04354610, Nancy-CovH-AKI Phase Not Applicable Recruiting 1 5 Months 57 Antoine KIMMOUN, MD, PhD, Patrick ROSSIGNOL, MD, PhD 2020-05-01
FatCovid-19: Chronic Fatigue Etiology and Recovery in Covid-19 Patients: the Role of Fatigability Chronic fatigue syndrome, Coronavirus disease 19 infection actigraphy alone, blood test alone, electromyography alone, ergometer alone, magnetic resonance imaging alone, maximal effort test alone, neuromuscular evaluation alone, peripheral nerve stimulation alone, transcranial magnetic stimulation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Centre Hospitalier Universitaire de Saint Etienne Universite Jean Monnet France 2020-04-30 2021-12-31 2020-A00982-37, 20CH085, FatCovid-19, NCT04363606 Phase Not Applicable Not yet recruiting 3 20 Months 52 Guillaume THIERY, MD PhD, Jérome MOREL, MD PhD, Jérôme MOREL, MD PhD, Laurent GERGELE, MD, Lydia OUJAMAA, MD, Léonard FEASSON, MD PhD, Pascal GIRAUX, MD, Pierre CROISILLE, MD PhD 2020-04-29
MARIPOSA: A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia standard of care alone, tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Roche Holding AG 2020-05-04 2020-08-03 CA42481, MARIPOSA, NCT04363736 Phase 2 Clinical Not yet recruiting 0 3 Months 100 Clinical Trials 2020-04-29
COVIDeF: Cohort of Patients Infected With SARS-CoV2 (COVID-19) or Suspected of Being Coronavirus disease 19 infection Variable regimens including blood sampling Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-03-31 2022-03-31 2020-A00754-35, APHP200382, COVIDeF, NCT04352348 Phase Not Applicable Recruiting 1 24 Months 2000 Linda Gimeno, Pierre HAUSFATER, MD, Pierre Hausfater, MD 2020-04-30
COMBAT-COVID19: Colchicine in Moderate Severity Hospitalized Patients Before ARDS to Treat COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome colchicine alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Maimonides Medical Center US 2020-04-26 2021-06-30 2020-04-12, COMBAT-COVID19, NCT04363437 Phase 2 Clinical Recruiting 0 14 Months 70 Antonios Likourezos, MA, MPH, Antonios Likourezos, MPH, Felix Yang, MD 2020-05-01
Early Identification and Treatment of Cytokine Storm Syndrome in Covid-19 Coronavirus disease 19 infection, Respiratory failure anakinra alone Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Alabama at Birmingham US 2020-05-31 2020-12-31 CHATHAM-CYTOKINE COVID-19, NCT04362111 Phase 3 Clinical Not yet recruiting 0 7 Months 20 Angela Kendrach, Walter W Chatham, MD 2020-04-29
GETAFE: Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial Coronavirus disease 19 infection lenalidomide plus low molecular weight heparin (LMWH) Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario de Getafe Spain 2020-04-27 2020-12-31 COVID19-EC01, GETAFE, NCT04361643 Phase 4 Clinical Not yet recruiting 2 8 Months 120 Joaquin De Haro, MD, Joaquin De Haro, MD, PhD, Joaquin De Haro, MD,PhD 2020-04-30
Tocilizumab Treatment in Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Nacional de Cancerologia de Mexico Roche Pharma (Schweiz) AG Mexico 2020-04-01 2020-08-01 INF-3343-20-22-1, NCT04363853 Phase 2 Clinical Recruiting 1 4 Months 200 Diana Flores Estrada, Oscar G Arrieta, MD M Sc., Oscar G Arrieta, Oncologist, Oscar Gerardo Arrieta Rodríguez 2020-04-28
The Effects of Standard Protocol With or Without Colchicine in Covid-19 Infection Coronavirus disease 19 infection Variable regimens including azithromycin , ceftriaxone , colchicine , lopinavir + ritonavir , omega-3 , selenium , tiamine , vitamin A , vitamin C , vitamin D HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-03-20 2020-05-30 NCT04360980, SBMU.IR.REC.165423 Phase 2 Clinical Recruiting 2 2 Months 80 CKDRC,SBMU, MD, Nooshin Dalili, Dr, Nooshin Dalili, MD, SBMU, nooshin dalili 2020-04-28
COVID 19 Biomarkers Coronavirus disease 19 infection, Respiratory distress syndrome University of British Columbia Canada 2020-03-30 2021-09-30 H20-00971, NCT04363008 Phase Not Applicable Recruiting 4 18 Months 150 Cheryl Wellington, PhD, Mypinder Sekhon, Mypinder Sekhon, MD 2020-04-28
The Impact of COVID-19 Pandemic on the Smoking Behavior of Young Smokers and the Youth Quitline Service in Hong Kong Coronavirus disease 19 infection, Nicotine dependence Telephone survey alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) The University of Hong Kong Hong Kong 2020-04-24 2020-06-30 NCT02758028_1, NCT04360863 Phase Not Applicable Recruiting 1 2 Months 150 Ho Cheung William Li, PhD, Long Kwan Ho, MPhil 2020-04-28
Psychological Impact of Corona Virus Among Doctors in Assiut University Hospitals Acute stress disorder, Coronavirus disease 19 infection, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assiut University Egypt 2020-05-31 2021-06-30 NCT04363229, PSHYCOLOGICAL IMPACT OF CORONA Phase Not Applicable Not yet recruiting 1 13 Months 250 Mariam Roshdy Elkhayat, mariam elkhayat, MD, shimaa abdelsameaa, MD 2020-04-29
Clinical Impact of Bactek-R in Subject With Mild Pneumonia Due to COVID-19 Infection Coronavirus disease 19 infection, Viral pneumonia MV-130 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Inmunotek SL BioClever 2005 SL 2020-05-10 2020-07-31 MV130-SLG-35, NCT04363814 Phase 3 Clinical Not yet recruiting 0 2 Months 100 Guillermo Ángeles, Guillermo Ángeles, MD, M. Polanco, Martín Martín, MD, Miguel Casanovas, PhD, MD, Natalia García, Nicolas Batlle, MD, Raymundo Hernández 2020-04-28
ANACONDA: Anakinra for COVID-19 Respiratory Symptoms Coronavirus disease 19 infection, Respiratory disease anakinra alone, optimized standard of care alone Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Tours INSERM CIC-P 1415, Swedish Orphan Biovitrum AB 2020-04-27 2020-09-24 2020-001734-36, ANACONDA, ANACONDA-COVID-19, DR200111, NCT04364009 Phase 3 Clinical Not yet recruiting 0 4 Months 240 Alexandra AUDEMARD-VERGER, MD-PhD, Elodie MOUSSET 2020-04-29
A multicenter, randomized, double-blind, placebo-controlled, proof-of-concept, phase II trial of Metablok for lung and kidney inflammation in patients with COVID-19 Coronavirus disease 19 infection, Lung inflammation, Nephritis Metablok alone Dehydropeptidase-1 modulator Arch Biopartners Inc Phase 2 Clinical Planned 0 2020-04-28
LEAD COVID-19: The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations Blood clotting disorder, Coronavirus disease 19 infection, Vitamin D deficiency aspirin alone, aspirin plus vitamin D Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Louisiana State University Health Sciences Center New Orleans US 2020-05-31 2020-12-31 20-063, LEAD COVID-19, NCT04363840 Phase 2 Clinical Not yet recruiting 0 7 Months 1080 Frank H Lau, MD 2020-04-29
Alterations in inflammatory and coagulation variables in COVID-19 patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Munich Germany 2020-04-27 20-296, DRKS00021581 Phase Not Applicable Recruiting 1 100 Tobias Nitschke 2020-04-29
AziA: Azithromycin + Amoxicillin/clavulanate versus Amoxicillin/clavulanate in COVID-19 Patients With Pneumonia in Non-intensive Unit Coronavirus disease 19 infection, Viral pneumonia Variable regimens including amoxicillin + clavulanate , azithromycin , cephalosporin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CHU De Nantes France 2020-04-30 2020-07-30 AziA, NCT04363060, RC20_0168 Phase 3 Clinical Not yet recruiting 3 3 Months 104 Blandine RAMMAERT, MD, PhD, Emmanuel MONTASSIER, Romain DECOURS, MD, PhD, Vincent DUBEE, MD, PhD 2020-04-30
Sarilumab for Patients With Moderate COVID-19 Disease: A Randomized Controlled Trial With a Play-The-Winner Design Coronavirus disease 19 infection Variable regimens including hydroxychloroquine , remdesivir , sarilumab IL-6 receptor antagonist, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) VA Boston Healthcare System US 2020-04-10 2023-04-10 IRB 3305, NCT04359901 Phase 2 Clinical Recruiting 0 36 Months 120 Colleen Shannon, MPH, Patricia Woods, RN, MSN, Paul Monach, MD, Sara Schiller, MPH, Westyn Branch-Elliman, MD 2020-04-30
Identification of predictive biomarkers for severe progression of COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bundeswehrkrankenhaus Berlin Germany 2020-05-03 DRKS00021591, Eth-10/20 Phase Not Applicable Not yet recruiting 4 100 Christian Zobel, Maximilian Schreiner 2020-04-28
CytoResc: CytoSorb Rescue for COVID-19 Cytokine Storm Coronavirus disease 19 infection CytoSorb therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Charité Campus Virchow-Klinikum Germany 2020-05-01 CytoResc, DRKS00021447, EA1/069/20, U1111-1250-8875 Phase 2b Clinical Not yet recruiting 4 100 Philipp Enghardt, Torsten Slowinski 2020-04-30
Local Thermotherapy for Patients With Moderate Symptoms of COVID-19 Coronavirus disease 19 infection electric chest pad alone, electric cushion therapy alone, thermotherapy alone National Institute of Perinatology Directorate for Quality and Health Education, Juarez de Mexico Hospital, Laboratorios Silanes SA De CV Mexico 2020-04-30 2020-11-30 CONACYTF0005-2020-01S311971, NCT04363541, U1111-1250-7416 Phase Not Applicable Not yet recruiting 1 7 Months 298 Gabriela Ibañez Cervantes, PhD, Norma del Carmen Galindo Sevilla, PhD, Norma del Carmen Galindo-Sevilla 2020-04-30
ESCAPE: Evaluation of SARS-CoV-2 (COVID-19) Antibody-containing Plasma therapy Coronavirus disease 19 infection High-Titer COVID-19 Convalescent Plasma (HT-CCP) alone Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Brigham & Women's Hospital US 2020-04-30 2021-12-31 2020P001215, ESCAPE, NCT04361253 Phase 3 Clinical Not yet recruiting 0 20 Months 220 Karina Oganezova, Richard Kaufman, MD 2020-04-30
COVID.PPI: The influence of proton pump inhibitor therapy on the clinical course of COVID-19 Coronavirus disease 19 infection proton pump inhibitors therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Klinikum der Albert-Ludwigs Universitaet Freiburg Germany 2020-04-28 254/20, COVID.PPI, DRKS00021523 Phase Not Applicable Recruiting 1 200 Dominik Bettinger 2020-04-30
Impact of WeChat-based parenting education for children with autism spectrum disorder and their mothers during the epidemic of Coronavirus disease 2019 (COVID-19) Autism, Coronavirus disease 19 infection WeChat-based parenting education alone Preschool Children (2-5 yrs), Children (6-12 yrs) Fujian Maternity and Child Health Care Hospital China 2020-02-01 2020-10-31 ChiCTR2000031772 Phase 0 Clinical Recruiting 1 9 Months 105 Guihua Liu 2020-04-30
COVID-AGE: Clinical-epidemiological Characterization of COVID-19 Disease in Hospitalized Older Adults Coronavirus disease 19 infection glucocorticoids alone, Variable regimens including anakinra , azithromycin , baricitinib , ceftriaxone , emtricitabine + tenofovir , hydroxychloroquine , lopinavir + ritonavir HIV protease inhibitor, Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor, Type I IL-1 receptor antagonist Aged Adults (65-79 yrs), Elderly Adults (80 and over) Complejo Hospitalario Universitario de Albacete Spain 2020-04-20 2020-07-31 COVID-AGE, NCT04362943, PAS-BAR-2020-04 Phase 4 Clinical Recruiting 2 3 Months 576 Almudena Avendaño Céspedes, RN, PhD, Pedro Abizanda Soler, MD,PhD 2020-04-30
Use of the Interleukin-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure clazakizumab alone IL-6 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Johns Hopkins University US 2020-04-30 2020-07-31 IRB00247932, NCT04363502 Phase 2 Clinical Not yet recruiting 0 3 Months 30 Nada Alachkar, MD, Russell Wesson, MD 2020-04-30
PROTECT: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19) Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (IRST) SRL Universita di Bologna Italy 2020-05-31 2021-03-31 IRST100.47, NCT04363827, PROTECT Phase 2 Clinical Not yet recruiting 1 10 Months 2300 Giovanni Martinelli, Prof., Oriana Nanni, Pierluigi Viale, Prof. 2020-04-30
Study for Healthy Behavior, Psychological Analysis and Psychological Reconstruction Strategies of Students Population Keeping in Home Under the Pandemic of Novel Coronavirus Pneumonia (COVID-19) Coronavirus disease 19 infection, Psychiatric disorder Face-to-face consultation alone, Phone consultation alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Sun Yat-Sen University National Natural Science Foundation of China China 2020-03-18 2021-03-18 ChiCTR2000032095 Phase 0 Clinical Recruiting 1 12 Months 130 Peijia Liu 2020-04-30
The Danish Pre-HCQ COVID19 Dialysis Study: Hydroxychloroquine for prevention of COVID-19 in patients on chronic dialysis Coronavirus disease 19 infection Plaquenil alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rigshospitalet, Denmark Denmark 2020-04-15 2020-001257-51, The Danish Pre-HCQ COVID19 Dialysis Study Phase 3 Clinical Recruiting 1 568 Department of Nephrology 2132 2020-04-29
A pilot study in patients with SARS-CoV-2 infection Coronavirus disease 19 infection Hemogenyx Pharmaceuticals Ltd Phase Not Applicable Recruiting 0 2020-04-29
A Study for Efficacy and Safety of Live Biotherapeutic MRx-4DP0004 to Treat COVID-19 Coronavirus disease 19 infection MRx-0004 alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) 4D pharma plc UK 2020-05-31 2020-09-30 MRX-4DP0004-II-001, NCT04363372 Phase 2 Clinical Not yet recruiting 1 4 Months 90 Clinical Operations, Dinesh Saralaya, MBBS, MD, MRCP, FRCP 2020-04-30
Clinical Trial of Mycobacterium w in COVID-19 Positive Patients, Hospitalized But Not Critically Ill Coronavirus disease 19 infection Mycobacterium w alone, standard care therapy alone Interferon gamma receptor agonist, MAPK gene modulator, TLR-2 agonist, TLR-4 agonist, TLR-9 agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cadila Pharmaceuticals Ltd Council of Scientific and Industrial Research (India) 2020-04-30 2021-04-30 CRSC20006, NCT04358809 Phase 3 Clinical Not yet recruiting 0 12 Months 480 Anil Avhad, MBBS, Sanjay Patel, MBBS 2020-04-29
Pharmacological Ascorbic Acid as an Activator of Lymphocyte Signaling for COVID-19 Treatment Coronavirus disease 19 infection Ascor (McGuff Pharmaceuticals, Ltd) plus magnesium chloride Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Thomas Jefferson University US 2020-04-30 2021-04-30 JT#15681, NCT04363216 Phase 2 Clinical Not yet recruiting 0 12 Months 66 Dagan Coppock, M.D., Daniel Monti, M.D., Melissa McCarey, Michael W Foster, M.D. 2020-05-02
COroFet: Assessment of Obstetric, Fetal and Neonatal Risks and Vertical SARS-CoV-2 Transmission During COVID-19 Pandemic Coronavirus disease 19 infection RT-PCR alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-04-17 2022-04-30 COroFet, NCT04360811, RC31/20/0123 Phase Not Applicable Recruiting 1 24 Months 3600 Charlotte Dubucs, MD, Marion Groussolles, MD 2020-04-30
HCQPreP: Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Louisiana State University Health Sciences Center New Orleans Lafayette General Medical Center, University Of Louisiana At Lafayette US 2020-04-27 2020-08-03 HCQPreP, LSU NO HSC IRB 20-050, NCT04363450 Phase 3 Clinical Recruiting 0 3 Months 1700 Ann Chauffe, Ann D Chauffe, DO, MPH, Ann D. Chauffe, DO, MPH, Carl Sabottke, MD, Daniel Stout, MD, Daniel Stouts, MD, James B Falterman, MD, Nicholas Sells, MD, Rebecca B Lee, DO, MS, Rebecca B. Lee, DO, MS 2020-05-01
Comparison of VieScope versus Macintosh Laryngoscope for Intubation in Level Cpersonal Protective Equipment Conditions Coronavirus disease 19 infection, Edema Vie Scope laryngoscope alone, intubation alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lazarski University Medical University of Bialystok, Poznan University of Medical Sciences, Wroclaw Medical University Poland 2020-01-20 2020-02-25 INT_PPE_2020_1, NCT04363775 Phase Not Applicable Completed 1 1 Month 35 Łukasz Szarpak 2020-04-29
ACCESS: ACCESS A Master Digital Surveillance Protocol for COVID-19 Coronavirus disease 19 infection mobile app (Medable Inc) alone, wearable sensor alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medable Inc American Heart Association, Biointellisense Inc, Datavant, PWNHealth LLC US 2020-04-20 2031-10-01 ACCESS, NCT04363268, PRO00041635 Phase Not Applicable Recruiting 0 137 Months 1000000 Ingrid Oakley-Girvan, Ph.D., Ingrid Oakley-Girvan, PhD, Jena Daniels, B.S., Jena Daniels, BS, Michelle Longmire, M.D., Reem Yunis, Ph.D., Reem Yunis, PhD 2020-04-30
Effect of plasma of patients recovered from Covid-19 versus control group on treatment of Covid-19 Coronavirus disease 19 infection Variable regimens including chloroquine , lopinavir , plasma , ritonavir Cytochrome P450 3A4 inhibitor, HIV protease inhibitor, HIV-1 protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hamadan University of Medical Sciences Iran 2020-05-14 IR.UMSHA.REC.1399.037, IRCT20120215009014N353 Phase 2 Clinical Not yet recruiting 1 100 Dr. Ebrahim Jalili, Dr. Jalal Poorolajal, Dr. Saeid Bashirian, Samereh Ghelichkhani 2020-04-29
CAN-COVID: Study of Efficacy and Safety of Canakinumab Treatment for CRS in Participants With COVID-19-induced Pneumonia Coronavirus disease 19 infection, Viral pneumonia canakinumab alone, standard of care alone Immunoglobulin G1 agonist, Interleukin-1 beta ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Novartis AG, Novartis Farmaceutica SA Spain 2020-04-30 2020-10-05 2020-001370-30, CACZ885D2310, CAN-COVID, NCT04362813 Phase 3 Clinical Recruiting 1 5 Months 450 Novartis Pharmaceuticals, Trial Monitoring Organization (TMo) 2020-04-29
Dose-Finding Study of Ivermectin in the Treatment of COVID-19 Coronavirus disease 19 infection ivermectin alone, standard regimen therapy alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Qazvin University Of Medical Sciences Iran 2020-05-04 IR.QUMS.REC.1399.017, IRCT20200408046987N1 Phase 3 Clinical Not yet recruiting 2 100 Dr Abbas Allami, Dr. Aliakbar Karami, Nematollah Gheibi, dr. morteza shakhs niaee 2020-04-30
VA-REACH: VA Remote and Equitable Access to COVID-19 Healthcare Delivery Coronavirus disease 19 infection azithromycin alone, hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) San Francisco VA Health Care System US 2020-04-30 2021-08-31 20-30517, NCT04363203, VA-REACH Phase 4 Clinical Not yet recruiting 0 16 Months 600 Salomeh Keyhani, MD MPH, Staff Physician 2020-04-30
COVIDAM: An open-label, single-center, randomized, controlled trial to evaluate the effect of hydroxychloroquine on viral shedding in mild COVID-19 Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Institute of Tropical Medicine Belgium 2020-04-12 2020-001417-21, COVIDAM, ITM202004 Phase 2 Clinical Recruiting 1 206 Yven Van Herrewege 2020-04-29
A first-in-human trial of recombinant adenoviral vector vaccine targeting SARS-CoV-2 spike protein for the treatment in patients with COVID-19 infection Coronavirus disease 19 infection recombinant adenoviral vector vaccine targeting SARS-CoV-2 spike protein (liquid formulation, COVID-19), ReiThera alone COVID19 Spike glycoprotein modulator ReiThera Srl Italy Phase Not Applicable Planned 1 2020-04-29
ONCOVID-19: Prospective Analysis of Morbi-mortality of Patients With Cancers in Active Phase of Treatment Suspected or Diagnosed of a SARS-CoV-2 Infection Coronavirus disease 19 infection, Hematological neoplasm, Solid tumor medical treatment alone Centre Leon Berard France 2020-04-02 2020-06-30 ET20-069, NCT04363632, ONCOVID-19 Phase Not Applicable Recruiting 18 2 Months 150 Anne-Laure Anne-Laure, Dr., Blaha BELGADI, Dr., Charlotte FAUCHER, Dr., Dominique DRAMAIS, Dr., Guillaume Carbonnelle, Dr., Jean-Pierre DELORD, Pr., Jocelyne PROVENCAL, Dr., Julien GAUTIER, Julien PERON, Dr., Laetitia STEFANI, Dr., Magali BRIERE, Dr., Marianne HAMON, Dr., Nicolas MARTIN, Dr, Roland SCHOTT, Dr., Simon PERNOT, Dr., Souad ASSAAD, Dr, Stéphane LEPRETRE, Dr., Xavier DURANDO, Pr., Yacine MERROUCHE, Dr. 2020-04-30
PEEP Incremental and Decremental Alveolar Recruitment of Critically Ill Corona Virus Disease-19 (COVID-19) Patients Coronavirus disease 19 infection Electric Impedance Tomography (EIT) alone, positive end-expiratory pressure (PEEP) decremental alveolar recruitment alone, positive end-expiratory pressure (PEEP) incremental alveolar recruitment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Szeged Budapesti Müszaki És Gazdaságtudományi Egyetem, Hochschule Furtwangen, Germany Hungary 2020-05-01 2021-04-19 COVID-19EIT, NCT04360837 Phase Not Applicable Not yet recruiting 1 11 Months 10 András Lovas, MD PhD 2020-05-01
ROCOCO: Serology COVID-19 From the Cornwall Hospital Union Coronavirus disease 19 infection immunoglobulin (IgG) Dia-Pro serological test alone, serum test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier de Cornouaille Centre Hospitalier Regional Universitaire de Brest France 2020-05-04 2020-11-04 29BRC20.0122, NCT04363593, ROCOCO Phase Not Applicable Not yet recruiting 1 6 Months 3200 Marie-Sarah FANGOUS, PH 2020-04-29
RESPIRE: Ruxolitinib for the Treatment of Acute Respiratory Distress Syndrome in Patients With COVID-19 Infection Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia ruxolitinib alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) L'Azienda USL Nord Ovest Azienda Ospedaliera Universitaria Senese, Azienda Ospedaliero, Universitaria Pisana, Fondazione Toscana Gabriele Monasterio Italy 2020-04-25 2020-05-31 2020.COVID-19.RUXO106, NCT04361903, RESPIRE Phase Not Applicable Not yet recruiting 1 1 Month 13 Barbara Dr Meini, Pharmacist, Enrico Dr Capochiani, hematologist 2020-04-29
SJTRC: St. Jude Tracking of Viral and Host Factors Associated With COVID-19 Coronavirus disease 19 infection blood sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Jude Children's Research Hospital US 2020-04-23 2025-03-20 NCT04362995, SJTRC, SJTRC Phase Not Applicable Recruiting 0 58 Months 1517 Aditya H. Gaur, MD, Jeremie H. Estepp, MD, Joshua Wolf, MBBS, PhD, FRACP, Paul G. Thomas, PhD 2020-04-29
COPEP: Efficacy of Pragmatic Same-day COVID-19 Ring Prophylaxis for Adult Individuals Exposed to SARS-CoV-2 in Switzerland Coronavirus disease 19 infection Plaquenil alone, lopinavir + ritonavir alone HIV protease inhibitor Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires De Geneve Switzerland 2020-04-30 2020-10-31 CCER 2020-00864, COPEP, NCT04364022 Phase 3 Clinical Recruiting 2 6 Months 420 Alexandra Calmy, Prof, Niklaus Labhardt, Prof 2020-04-29
OSACOVID-19: Obstructive Sleep Apnea and Covid-19 Outcomes Coronavirus disease 19 infection, Obstructive sleep apnea, Viral pneumonia polysomnography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Koc University Turkey 2020-04-27 2020-12-31 2020.140.IRB1.030, NCT04363333, OSACOVID-19 Phase Not Applicable Recruiting 1 8 Months 275 The OSACOVID-19 Study Group, Yeliz Celik, MSc, Yuksel Peker, MD, PhD 2020-04-30
Arkansas Expanded Access COVID-19 Convalescent Plasma Treatment Program Coronavirus disease 19 infection convalescent plasma alone, acetaminophen plus diphenhydramine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Arkansas 260944, NCT04363034 Phase Not Applicable Recruiting 0 Danielle Evans, David Avery 2020-04-30
PLACID: Study to assess the efficacy and safety of convalescent plasma in moderate COVID-19 disease Coronavirus disease 19 infection Usual care alone, convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Indian Council of Medical Research India 2020-04-22 CTRI/2020/04/024775, PLACID, Protocol v 1.1 Phase 2 Clinical Not yet recruiting 2 452 DR Sunita Bundas, Dr Anup Agarwal, Dr Aparna Mukherjee, Dr J R Khambolja 2020-05-01
A Pilot Study to Assess Hydroxychloroquine in Patients With SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection, Viral pneumonia hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Oregon Health Sciences University OHSU Knight Cancer Institute US 2020-05-31 2021-06-30 NCT04363866, STUDY00021303 Phase 4 Clinical Not yet recruiting 0 13 Months 40 Brett Rodgers, Marcel Curlin, MD 2020-04-29
Novel Artificial Intelligence Algorithm to screen COVID-19 Patients from X-Ray , CT-Scan of Thorax and Voice Sampling through Android App and storage through Cloud Coronavirus disease 19 infection Android App alone, Chest X-Ray Artificial Intelligence Module alone, THORAX CT-Scan Artificial Intelligence Module alone, Voice Sampling Artificial Intelligence Module alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rabindranath Tagore Medical College India 2020-04-23 CTRI/2020/04/024776 Phase Not Applicable Recruiting 2 1650 Dr Arvind Kumar Morya, Dr Mahesh Mahich 2020-05-01
Immune Cells in Inflammatory Arthritis With Coronaviruses, Including COVID-19 Coronavirus disease 19 infection, Rheumatoid arthritis Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Manchester UK 2020-05-01 2021-05-01 282566, NCT04363047 Phase Not Applicable Not yet recruiting 1 12 Months 125 Anne C Barton, Dr. Sebastien Viatte, Lynne Macrae 2020-04-29
AdoPro-Cov19: Adolescents and Health Professionals Faced With the Necessity for Changing to Remote Care During the COVID-19 Outbreak Quarantine Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Hôpital Cochin INSERM France 2020-05-31 2020-12-31 AdoPro-Cov19, NCT04363671, P20-670 Phase Not Applicable Not yet recruiting 1 7 Months 30 Carretier Emilie, Emilie Carretier, MD, Jonathan Lachal, PhD 2020-04-28
Clinical and Immunologic Impact of Perinatal SARS-CoV-2 (COVID-19) Infection Coronavirus disease 19 infection, Cough, Fever, Viral pneumonia Female Fundacion Infant Argentina 2020-05-01 2020-09-30 NCT04362956, PERINATAL COVID-19 Phase Not Applicable Not yet recruiting 1 5 Months 200 Gaston Ofman, Head of Perinatal Research, Gaston Ofman, MD 2020-04-29
RuXoCoil: Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS Coronavirus disease 19 infection, Viral pneumonia ruxolitinib (oral, myeloproliferative disorders), Incyte/Novartis alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Philipps-Universitat Marburg Germany 2020-05-31 2020-11-30 KKS-278, NCT04359290, RuXoCoil Phase 2 Clinical Not yet recruiting 1 6 Months 15 Andreas Burchert, Prof Dr., Andreas Neubauer, Prof Dr. 2020-04-30
A medical records based study for epidemiological characteristics of 88 patients with new coronavirus pneumonia (COVID-19) and its impact on severe disease Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) First People's Hospital of Jiangxia District, Wuhan (Union Jiangnan Hospital) China 2020-01-29 2020-03-16 ChiCTR2000032239 Phase Not Applicable Recruiting 1 1 Month 88 Gu Xue 2020-04-29
COVIDITY: A Phase I Study of Vaccine SCIB-1 For the Treatment of COVID-19 Coronavirus disease 19 infection SCIB-1 alone Immunoglobulin Fc receptor modulator Scancell Ltd Nottingham Trent University, University of Nottingham UK 2021-03-31 COVIDITY Phase 1 Clinical Planned 1 Christopher Coleman, Dr. Sally Adams, Graham Pockley, James Dixon, Janet Daly, Jonathan Ball, Lindy Durrant 2020-04-29
CoCo-Neuro: Cohort of Patients With Covid-19 Presenting Neurological or Psychiatric Disorders Coronavirus disease 19 infection, Neurological disease, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris 2020-04-24 2022-04-24 APHP200525, CoCo-Neuro, NCT04362930 Phase Not Applicable Not yet recruiting 0 24 Months 2000 CECILE DELORME, MD, Jean-Christophe CORVOL, MD,PHD 2020-04-29
Investigation of the B- and T-cell Repertoire and Immune Response in Patients With Acute and Resolved COVID-19 Infection Coronavirus disease 19 infection blood sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Cancer Institute National Institutes of Health Clinical Center US 2020-05-05 2024-12-01 20-C-0103, 200103, NCT04362865 Phase Not Applicable Recruiting 0 54 Months 150 Leah E Hoffman, R.N., Robert J Kreitman, M.D. 2020-05-01
A trial to evaluate plasma therapy for the treatment of COVID-19 patients Coronavirus disease 19 infection plasma therapy alone Korea Center for Disease Control & Prevention South Korea Phase 2 Clinical Recruiting 1 2 2020-04-28
A clinical trial of a plasma therapy for the treatment of patients with Covid-19 Coronavirus disease 19 infection plasma therapy alone Korea Center for Disease Control & Prevention South Korea 2020-07-31 Phase Not Applicable Planned 1 2020-04-28
Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19 Coronavirus disease 19 infection Hydroxychloroquine plus nitazoxanide Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Tanta University Egypt 2020-05-31 2020-12-31 HCQ/NTZ, NCT04361318 Phase 2/Phase 3 Clinical Not yet recruiting 1 7 Months 100 Kamal Okasha, MD, PhD 2020-04-30
Comparison of suspected or negative cases with confirmed cases of COVID-19 at Max Hospital Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India India 2020-04-28 CTRI/2020/04/024772 Phase Not Applicable Not yet recruiting 1 90 Samreen Siddiqui, Sujeet Jha 2020-04-29
A trial to remotely monitor the cardiac safety of patients with COVID-19 via data gathered from Withings Move ECG Watch Cardiotoxicity drug-induced, Coronavirus disease 19 infection Withings Move ECG Watch alone Cardiologs Technologies France Phase Not Applicable Status not specified 1 Jean-Claude Deharo 2020-04-28
Study to Evaluate the Efficacy of Recombinant BCG VPM1002 in Reducing Infection Incidence and Disease Severity of SARS-COV-2/COVID-19 Among High-Risk Subjects Coronavirus disease 19 infection VPM-1002 alone Listeriolysin stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Serum Institute of India Privated Ltd India 2020-04-21 CTRI/2020/04/024749, SII-rBCG/COVID-19/IN-01 Phase 3 Clinical Not yet recruiting 5 5946 Dr Hitt Sharma, Dr Pradeep Dcosta, Dr Sanjay Lalwani, Dr Savita Verma, Dr Umesh Shaligram, Dr Vasudev Rajapantula, Dr Venkat Rao 2020-04-29
A multicenter, randomized, double-blind, placebo-controlled trial for Xiang-Sha-Liu-Jun Pill in the treatment of novel coronavirus pneumonia (COVID-19) decline in digestive function during convalescence Coronavirus disease 19 infection, Dyspepsia, Viral pneumonia Xiang-Sha-Liu-Jun pill alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ezhou Hospital of traditional Chinese Medicine in Hubei Province State Administration of Traditional Chinese Medicine People's Republic of China China 2020-04-01 2020-06-30 ChiCTR2000032237, ChiMCTR2000003234 Phase Not Applicable Recruiting 1 3 Months 200 Hong Ying, Shao Xianzhi 2020-04-29
Clinical study for the potential impact of novel coronavirus pneumonia (COVID-19) on endocrine system Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shanghai Jiao Tong University China 2020-04-23 2020-05-06 ChiCTR2000032233 Phase Not Applicable No longer recruiting 2 28 Jiang Lai, Mao Yanfei 2020-04-29
COVID-19 Patient Positioning Pragmatic Trial Coronavirus disease 19 infection Prone position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Vanderbilt University Medical Center, US US 2020-04-27 2021-06-30 200727, NCT04359797 Phase Not Applicable Recruiting 0 14 Months 300 Todd W Rice, MD, MSc 2020-04-30
COVAPID: Impact of COVID-19 Infection on the Incidence of Ventilator-acquired Infections Coronavirus disease 19 infection, Influenza virus infection, Lower respiratory tract infection, Viral pneumonia mechanical ventilation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille France 2020-04-30 2020-07-31 2020-A00995-34, 2020_27, COVAPID, NCT04359693 Phase Not Applicable Not yet recruiting 1 3 Months 1071 Saad Nseir, MD,PhD 2020-04-30
Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- or Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers Coronavirus disease 19 infection, Viral respiratory tract infection nitazoxanide (controlled-release, viral infections), Romark alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Romark Laboratories LC 2020-04-27 2020-08-31 NCT04359680, RM08-3007 Phase 3 Clinical Recruiting 0 4 Months 800 Matthew Bardin, PharmD, BCPS 2020-04-30
COVASE: Nebulized Dornase Alfa for Treatment of COVID-19 Coronavirus disease 19 infection, Inflammatory disease dornase alfa alone, standard of care alone Deoxyribonuclease I stimulator, Deoxyribonuclease stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of London UK 2020-05-01 2020-11-01 132333, COVASE, NCT04359654 Phase 2 Clinical Not yet recruiting 1 6 Months 50 Donna Basire, Joanna Porter, MD PhD, Misha Ladva, Novin Fard 2020-05-01
BCG-Denmark versus no-BCG for COVID 19 prevention Coronavirus disease 19 infection BCG-Denmark alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Jawaharlal Institute of Postgraduate Medical Education Research India 2020-05-01 CTRI/2020/04/024833 Phase 3 Clinical Not yet recruiting 1 1826 Narayanan Parameswaran 2020-04-29
Imatinib in COVID-19 infection Coronavirus disease 19 infection imatinib alone Abl tyrosine kinase inhibitor, Bcr protein inhibitor, Kit tyrosine kinase inhibitor, PDGF receptor antagonist, Signal transduction inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences India 2020-04-26 CTRI/2020/04/024806 Phase 2 Clinical Recruiting 1 100 Akash Kumar 2020-04-29
Impact of Covid-19 pandemic on practice pattern of Indian urologists Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over), Asian Ancestry Sanjay Gandhi Postgraduate Institute of Medical Sciences India 2020-04-24 CTRI/2020/04/024805 Phase Not Applicable Not yet recruiting 1 160 Sanjoy Kumar Sureka 2020-04-28
Screening of proprietary Chinese medicines in convalescent rehabilitation of novel coronavirus pneumonia (COVID-19) convalescent patients Anxiety disorder, Coronavirus disease 19 infection, Depression, Insomnia, Viral pneumonia shumian capsule alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hubei province hospital of Traditional Chinese Medicine Ministry of Science and Technology of the People´s Republic of China China 2020-04-01 2020-07-10 ChiCTR2000032214, ChiMCTR2000003233 Phase Not Applicable Not yet recruiting 3 3 Months 200 Ba Yuanming, Li Li 2020-04-29
Evaluation of safety and efficacy of convalescent plasma in COVID-19 patients Coronavirus disease 19 infection convalesecent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) International Stemcell Services Limited India 2020-04-30 CTRI/2020/04/024804, F. No. X. 11026/71/2020-BD, IMD/CoV/003/2020 Phase 2 Clinical Recruiting 1 Dr Jyothnsa Rao, Dr Vishal Rao, Meena Dalal 2020-04-29
A medical records based study for the impact of wearing medical masks on oxygen saturation in adult surgical patients after general anesthesia during novel coronavirus pneumonia (COVID-19) pandemic Coronavirus disease 19 infection medical masks alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) First Affiliated Hospital of Chongqing Medical University China 2020-04-23 2020-05-23 ChiCTR2000032213 Phase Not Applicable Recruiting 1 1 Month 151 Feng Lv, Su Min 2020-04-28
Effectiveness to Manage Covid 19 Pandemic by Teaching Ventilatory Management to Non-anesthesiology Residents Coronavirus disease 19 infection ventilatory management teaching alone Young Adults (18-44 yrs) GSL Medical College India 2020-01-01 CTRI/2020/04/024747 Phase Not Applicable Not yet recruiting 1 26 TATIKONDA CHANDRA MOULI 2020-04-29
A medical records based retrospective study for the effectiveness and safety of Xi-Yan-Ping injection combined with conventional protocol in the treatment of common type novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Xiyanping alone, conventional treatment alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shanghai Public Health Clinical Center China 2020-05-15 2020-08-22 ChiCTR2000032412 Phase Not Applicable Not yet recruiting 1 3 Months 426 Hongzhou Lu, Lin Wenjun 2020-04-29
The efficacy and safety of high dose intravenous vitamin C in the treatment of novel coronavirus pneumonia (COVID-19): a prospective, randomized, controlled trial Coronavirus disease 19 infection, Viral pneumonia Vitamin C alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rui Jin Hospital Science and Technology Commission of Shanghai Municipality China 2020-01-01 2020-06-01 ChiCTR2000032400 Phase 2 Clinical Recruiting 1 5 Months 120 Bing Zhao, Enqiang Mao 2020-04-29
A multicenter, randomized, double-blind, placebo-controlled trial for Xiaoyao capsule in the improvement of sleep mood disorder of convalescence patients of novel coronavirus pneumonia (COVID-19) Anxiety disorder, Coronavirus disease 19 infection, Viral pneumonia xiaoyao capsule alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Xiaogan Traditional Chinese Medicine Hospital Ministry of Science and Technology of the People´s Republic of China China 2020-04-01 2020-07-01 ChiCTR2000032399, ChiMCTR2000003249 Phase not specified Recruiting 3 3 Months 200 Yang Guiping, Zhou Jing 2020-04-29
TRONCHER: Assessment of Efficacy and Safety of Tocilizumab Compared to Deferoxamine, Associated With Standards Treatments in COVID-19 (+) Patients Hospitalized In Intensive Care in Tunisia Coronavirus disease 19 infection usual standard treatment alone, enoxaparin sodium plus tocilizumab Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Abderrahmane Mami Hospital Datametrix AG, Eshmoun Clinical Research Centre Tunisia 2020-05-04 2020-10-04 ECC2020-06, NCT04361032, TRONCHER Phase 3 Clinical Not yet recruiting 1 5 Months 260 Chokri Jeribi, Dr, Dr Jalila Ben Khelil, Eshmoun Clinical Research Centre 2020-04-29
Physical Activity in University Students Around COVID-19 Confinement Coronavirus disease 19 infection, Pain online survey alone Healthy volunteers accepted Universidad del Pais Vasco Universidad De Cantabria, Universidad De Castilla-La Mancha, Universidad De Las Palmas De Gran Canaria, Universidad Miguel Hernandez de Elche, Universidad Politecnica de Madrid, Universidad Publica De Navarra, Universidad de Extremadura, Universidad de Sevilla, Universidad de Zaragoza, Universitat Jaume I de Castelló, Universitat de les Illes Balears, University of Cadiz, University of Granada, University of León, University of Valencia Spain 2020-04-16 2020-10-20 COVID_PA2020, NCT04361019 Phase Not Applicable Recruiting 1 6 Months 25000 Ana Rodriguez, PhD, Ander Espin, MSc, Ander Espin, Ph D, Diego Jimenez, PhD, Diego Moliner, PhD, Domingo Gonzalez, PhD, Francisco B Ortega, PhD, Francisco J Vera, PhD, Idoia Labayen, PhD, Ignacio Ara, PhD, Jon Irazusta, PhD, Jonatan Ruiz, PhD, Jose Antonio Casajus, PhD, Jose Antonio Serrano, PhD, Jose Castro, PhD, Josep Tur, PhD, Luis Carrasco, PhD, Marcela Gonzalez, PhD, Mari Carmen Gomez, PhD, Maria Jose Cuevas, PhD, Maria Jose Noriega, PhD, Narcis Gusi, PhD, Pedro J Benito, PhD, Susana Aznar, PhD 2020-04-28
PSY-CO-CHU: Anxiety and Work Resilience Among Tertiary University Hospital Workers During the COVID-19 Outbreak: an Online Survey Anxiety disorder, Coronavirus disease 19 infection, Insomnia, Pain Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Nimes France 2020-04-09 2020-04-22 LOCAL COVID 2019/JYL-01), NCT04358640, PSY-CO-CHU Phase Not Applicable Recruiting 1 2000 Jean-Yves LEFRANT, Jean-Yves LEFRANT, MD,PhD, Jean-Yves Lefrant, MD,PhD 2020-04-29
COVID-19 Mortality Prediction Model Coronavirus disease 19 infection, Viral pneumonia COViage alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dascena US 2020-04-01 2020-04-17 04202001, NCT04358510 Phase Not Applicable Completed 0 114 2020-04-30
COSA: Registry of COVID-19 Patients Treated With the Seraph 100 Microbind Affinity Blood Filter Coronavirus disease 19 infection, Respiratory failure Seraph 100 Microbind affinity blood filter alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hannover Medical School Germany 2020-04-15 2021-10-01 COSA, COSA-8998, NCT04361500 Phase Not Applicable Recruiting 2 17 Months 100 Bernhard MW Schmidt, Jan T Kielstein, Prof, Julius J Schmidt, Julius J Schmidt, Dr 2020-04-28
KICC-COVID19: Keto-diet for Intubated Critical Care COVID-19 Coronavirus disease 19 infection, Respiratory failure Ketogenic diet alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Johns Hopkins University US 2020-04-20 2020-08-01 IRB00247383, KICC-COVID19, NCT04358835 Phase Not Applicable Not yet recruiting 0 3 Months 15 Mackenzie Cervenka, MD, Tanya McDonald, MD PhD 2020-04-29
Clinical Features and Risk Factors Associated With Worse Outcome in Patients Hospitalized for COVID-19 Pneumonia Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-04-09 2020-05-17 7773, NCT04362345 Phase Not Applicable Recruiting 1 1 Month 100 Antonin HUGEROT, MD, Charlotte KAEUFFER, MD, Coralie LE HYARIC, MD, François DANION, MD, Joy MOOTIEN, MD, Nicolas LEFEBVRE, MD, Nicolas MEYER, MD, PhD, Olivier HINSCHBERGER, MD, Saïd CHAYER, PhD, HDR, Yves HANSMANN, MD, PhD, Yvon RUCH, MD 2020-05-01
MARNEVO-Covid: Neurodegeneration Markers and Neurological Course in Severe Covid-19 Infection Coronavirus disease 19 infection, Epilepsy, Viral encephalitis blood sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier de PAU 2020-05-05 2021-01-05 CHPAU2020/02, MARNEVO-Covid, NCT04361344 Phase Not Applicable Not yet recruiting 0 8 Months 30 2020-04-28
START: START (Siddha Treatment Accelerating Recovery from SARS-CoV-2 Test) trial of Siddha treatment for patients with novel coronavirus infectious disease (COVID-19) Coronavirus disease 19 infection standard care alone, Brammanandha bairavam plus Kabasura kudineer Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Eminentlabs GmbH India 2020-04-17 2020-06-26 ISRCTN13311119, NV-05-943-2020, START Phase 2 Clinical Recruiting 1 2 Months 116 Mr Thanicakachalam 2020-04-29
RAPID COVID COAG: Coagulopathy of COVID-19: A Pragmatic, Randomized, Controlled Trial of Therapeutic Anticoagulation Versus Standard Care Blood clotting disorder, Coronavirus disease 19 infection dalteparin sodium alone, enoxaparin sodium alone, tinzaparin sodium alone, unfractionated heparin alone Antithrombin III, Factor IIa antagonist, Factor Xa antagonist, Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Michaels Hospital University of Vermont Medical Center US, Canada 2020-04-30 2020-12-31 NCT04362085, RAPID COVID COAG, RAPID COVID-COAG Phase 3 Clinical Not yet recruiting 1 8 Months 462 Mary Cushman, MD, Michelle Sholzberg, MD, FRCPC, Peter Jüni, MD, FESC 2020-04-28
A phase IIb/III, multinational, adaptive pilot to pivotal trial design of NP-120 in COVID-19 infected patients from progressing to mechanical ventilation with intubation and death Coronavirus disease 19 infection ifenprodil (injectable/intravenous, COVID-19/acute lung injury), Nash Pharmaceuticals alone, standard of care alone NMDA receptor epsilon 2 subunit inhibitor Algernon Pharmaceuticals US Phase Not Applicable Not yet recruiting 0 100 2020-04-27
COVSurf: A Clinical Trial of Nebulized Surfactant for the Treatment of Moderate to Severe COVID-19 Coronavirus disease 19 infection COVSurf drug delivery system alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Southampton NHS Foundation Trust Bill & Melinda Gates Foundation, University College London UK 2020-04-27 2020-11-02 COVSurf, NCT04362059, RHM CRI0399 Phase Not Applicable Not yet recruiting 1 6 Months 24 Danny B Pratt, Michael P Grocott, MD 2020-04-29
Expanded Access to Convalescent Plasma to Treat and Prevent Pulmonary Complications Associated With COVID-19 Coronavirus disease 19 infection, Viral pneumonia anti-SARS-CoV-2 convalescent plasma cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tulane University School of Medicine US 2020-595, NCT04358211 Phase Not Applicable Recruiting 0 Nakhle Saba, MD 2020-04-28
Evaluation of Antibody Tests for COVID-19 Coronavirus disease 19 infection rapid-format, point-of-care antibody test kit alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US US 2020-04-27 2020-10-27 202004088, NCT04360954 Phase Not Applicable Recruiting 0 6 Months 1000 Gary Weil, MD, Peter Fischer, PhD, Teresa Tufte, MPH 2020-04-29
STOP COVID 19: Sequencing and Tracking of Phylogeny in COVID-19 Study Coronavirus disease 19 infection Nanopore-based whole genome sequencing alone, phylogenetic analysis alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Portsmouth Hospitals University of Portsmouth UK 2020-05-31 2022-09-30 NCT04359849, PHT/2020/34, STOP COVID 19 Phase Not Applicable Recruiting 1 28 Months 500 Alice Mortlock, Samuel Robson 2020-04-28
A clinical study of atexakin alfa for the treatment in patients with COVID-19-induced ARDS Coronavirus disease 19 infection, Respiratory distress syndrome atexakin alfa alone IL-6 receptor agonist Real Relief Holding ApS NeuroRx Inc US Phase Not Applicable Not yet recruiting 0 2020-04-27
Plasma Therapy of COVID-19 in Critically Ill Patients Coronavirus disease 19 infection anti-SARS-CoV-2 convalescent plasma cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Columbia University New York Blood Center US 2020-04-21 2021-04-30 AAAS9924, NCT04359810 Phase 2 Clinical Recruiting 0 12 Months 105 Andrew Eisenberger, MD, Max O'Donnell, MD, Walter I. Lipkin, MD 2020-05-01
CHEER: Efficacy of Various Doses of Hydroxychloroquine in Pre-Exposure Prophylaxis for COVID-19 Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Shaheed Zulfiqar Ali Bhutto Medical University Islamabad Pakistan 2020-04-25 2020-09-25 CHEER, F.1-1/2015/ERB/SZABMU/549, NCT04359537 Phase 2 Clinical Not yet recruiting 1 5 Months 200 Fibhaa Syed, FRCP, Mohammed Ali Arif, FRCP, Rauf Niazi, FRCP 2020-04-29
Treatment Of Coronavirus Disease 2019 (COVID-19) With Anti-Sars-CoV-2 Convalescent Plasma (ASCoV2CP) Coronavirus disease 19 infection Anti-Sars-CoV-2 convalescent plasma alone US Army Medical Research and Development Command NCT04360486, S-20-02 Phase Not Applicable Recruiting 0 Andrew P Cap, MS, MD, PhD, FACP 2020-04-29
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection) Coronavirus disease 19 infection, Systemic inflammatory response syndrome standard of care alone, tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Emory University National Cancer Institute US 2020-05-30 2022-05-30 NCI-2020-02314, NCT04361552, P30CA138292, STUDY00000419, WINSHIP4998-20 Phase 3 Clinical Recruiting 0 24 Months 180 Ajay K Nooka, Ajay K. Nooka, Shondolyn D. Richburg 2020-04-29
COVID19 LTFU: Long-Term Outcomes of Patients With COVID-19 Coronavirus disease 19 infection physical disability assessment tool alone, psychological Sequelae assessment tool alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Chicago US 2020-04-08 2021-12-30 20-0538, COVID19 LTFU, NCT04360538 Phase Not Applicable Recruiting 0 20 Months 500 Anne Pohlman, MSN, Bhakti Patel, MD, John Kress, MD, Krysta Wolfe, MD 2020-04-29
Pulsed Inhaled Nitric Oxide for the Treatment of Patients With Mild or Moderate COVID-19 Coronavirus disease 19 infection nitric oxide (inhaled, INOpulse), Bellerophon alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bellerophon Therapeutics LLC NCT04358588, PULSE-EAP-001 Phase Not Applicable Recruiting 0 Hunter Gilles, MD, Michelle Alamo, Valerie Parker 2020-04-29
THROMBOVID: Study of Hemostasis in Case of Severe COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg 2020-04-17 2021-05-01 7774, NCT04359992, THROMBOVID Phase Not Applicable Not yet recruiting 0 12 Months 50 Charles TACQUARD 2020-04-29
LIINC: Long-term Impact of Infection With Novel Coronavirus (COVID-19) Coronavirus disease 19 infection biological sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California San Francisco US 2020-04-21 2024-12-21 20-30479, LIINC, NCT04362150 Phase Not Applicable Recruiting 0 56 Months 800 Michael J Peluso, MD, Rebecca Hoh, Rebecca Hoh, MS, RD, Steven Deeks, MD, Steven G Deeks, MD 2020-04-30
Efficacy of tenofovir in covid-19 Coronavirus disease 19 infection hydroxychloroquine plus tenofovir disoproxil fumarate DNA polymerase inhibitor, HIV-1 reverse transcriptase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ardabil University of Medical Sciences Iran 2020-04-29 IR.AUMS.REC.1399.051, IRCT20200421047155N1 Phase 3 Clinical Recruiting 1 86 Shahab Bohlooli, Shahram Habibzadeh, Sina Parsay 2020-04-30
A 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells for the treatment of COVID-19 associated with lung inflammation Coronavirus disease 19 infection, Lung inflammation umbilical cord-derived mesenchymal stem cells (intravenous, COVID-19/lung inflammation/acute lung injury/acute respiratory distress syndrome), University of Miami alone KCNQ2 Cure Alliance Foundation, University of Miami Miller School of Medicine US Phase Not Applicable Not yet recruiting 0 24 Camillo Ricordi, M.D 2020-04-29
CV-COVID-19: Long-term Effects of Coronavirus Disease 2019 on the Cardiovascular System Cardiac failure, Coronavirus disease 19 infection, Heart arrhythmia, Myocardial infarction, Stroke, Sudden cardiac death real-time reverse transcriptase-polymerase chain reaction alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinic of Barcelona Spain 2020-04-20 2025-08-31 CV-COVID-19, HCB/2020/0457, NCT04359927 Phase Not Applicable Recruiting 1 64 Months 10000 Luis Ortega Paz, MD, PhD, Luis Ortega, MD, PhD, Manel Sabaté, MD, PhD, Salvatore Brugaletta, MD, PhD 2020-04-30
FIC: Favipiravir in Hospitalized COVID-19 Patients Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-04-20 2020-05-05 FAVIPIRAVIR IN COVID-19, FIC, NCT04359615 Phase 4 Clinical Not yet recruiting 1 40 Mehran Lack, MD, Mohammad Fathi, MD, Nader Markazi, MD, Nasser Malekpour Alamdari, MD, Sanaz Zargar Balaye Jam, MD, Sasan Tavana, MD, Seyed Sina Naghibi Irvani, MD, MPH, MBA 2020-04-30
Plasma Collection From Convalescent and/or Immunized Donors for the Treatment of COVID-19 Coronavirus disease 19 infection convalescent immune plasma alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institutes of Health Clinical Center US 2020-04-21 2030-04-14 20-CC-0092, 200092, NCT04360278 Phase Not Applicable Recruiting 0 119 Months 1500 Kamille A West, M.D. 2020-05-01
Ivermectin and Nitazoxanide Combination Therapy for COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure ivermectin plus nitazoxanide Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Tanta University Egypt 2020-05-31 2020-12-31 IVR/NTZ, NCT04360356 Phase 2/Phase 3 Clinical Not yet recruiting 1 7 Months 100 Kamal Okasha, Md, PhD, Nahla Elashmawy, Md, PhD 2020-04-30
VTE COVID: Increased Risk of VTE and Higher Hypercoagulability in Patients Recovered in ICU and in Medical Ward for COVID-19 Coronavirus disease 19 infection, Thromboembolism fondaparinux sodium alone, low-molecular-weight heparin alone Factor Xa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Quovadis Associazione Azienda Ospedaliera di Padova Italy 2020-05-31 2020-06-30 NCT04359212, VTE COVID, VTE COVID Phase Not Applicable Not yet recruiting 1 1 Month 80 Giuseppe Camporese, MD, Paolo Simioni, MD 2020-04-29
Evaluation efficacy of a herbal combination (contains Glycyrrhiza glabra, Mentha pulegium and Urtica) in controlling symptoms in patients with COVID-19 Coronavirus disease 19 infection herbal extract (Glycyrrhiza glabra, Mentha pulegium and Urtica) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Baqiyatallah University of Medical Sciences Iran 2020-03-30 2020-05-31 IR.BMSU.REC.1399.054, IRCT20080901001165N49 Phase Not Applicable Recruiting 1 2 Months 80 Ali Ghazivini, Dr. Rezaeiyan, Hossein Biganeh, Parisa Kianpour, Siamak Mohammadi, Yunes Panahi 2020-04-27
The effect of Naproxen in recovery and reducing mortality in patients with COVID-19 Coronavirus disease 19 infection naproxen alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Iran University of Medical Sciences Iran 2020-04-13 IR.IUMS.REC.1399.001, IRCT20200410047009N1 Phase 4 Clinical Recruiting 1 101 Maryam Esghaei 2020-04-29
effects of the 2-drug diet (hydroxychloroquine + umifenovir(Arbidol)) compared with Hydroxy chlorquine on the of mortality rate in patients with moderate symptoms of COVID-19 infections Coronavirus disease 19 infection Arbidol plus hydroxychloroquine, Amin Pharmaceutical Company Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Mashhad University of Medical Sciences Iran 2020-04-22 IR.MUMS.REC.1399.103, IRCT20200325046859N2 Phase 2/Phase 3 Clinical No longer recruiting 1 40 Rozita Khodashahi 2020-04-28
Evaluation of the colchicine tablet efficacy as an adjuvant therapy for patients with mild to moderate COVID-19 Coronavirus disease 19 infection colchicine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mashhad University of Medical Sciences Iran 2020-04-29 IR.MUMS.REC.1399.096, IRCT20200408046990N2 Phase 3 Clinical Recruiting 1 40 Sepideh Elyasi 2020-04-30
Atrium COVID-19 Syndromic and Serological Surveillance Coronavirus disease 19 infection daily syndromic surveillance alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Atrium Health US 2020-04-30 2021-12-31 04-20-11A, NCT04361123 Phase Not Applicable Recruiting 0 20 Months 450000 Michael Runyon, MD, MPH 2020-05-01
Use of Hydroxychloroquine Alone or Associated for Inpatients With SARS-CoV2 Virus (COVID-19) Coronavirus disease 19 infection, Lung disease, Sepsis, Viral pneumonia Reuquinol alone, Reuquinol plus azithromycin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Apsen Farmaceutica SA Universidade Federal de Sao Paulo - UNIFESP Brazil 2020-05-04 2020-11-04 APS001/2020, NCT04361461 Phase 3 Clinical Not yet recruiting 1 6 Months 500 Dr. Eduardo Alexandrino Servolo de Medeiros, M.D, Fernanda Martinez, B.Sc. 2020-04-28
Precision Immunology to Determine the Immune Response in Patients With COVID-19 Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Bonn Germany 2020-04-20 2022-09-30 BOST-03, NCT04360733 Phase Not Applicable Recruiting 1 29 Months 200 Chrisitan Bode, MD, Christian Bode, MD, Dr. Christian Bode, Folkert Steinhagen, MD 2020-04-29
Effect of lithium carbonate on COVID-19 Coronavirus disease 19 infection lithium carbonate alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Mashhad University of Medical Sciences Iran 2020-05-02 IR.MUMS.REC.1399.145, IRCT20081019001369N5 Phase 2 Clinical Not yet recruiting 1 40 Hossein Hosseinzadeh, Javad Dehghan Nayyeri 2020-04-27
Pilot Clinical Trial of the Safety and Efficacy of Telmisartan for the Mitigation of Pulmonary and Cardiac Complications in COVID-19 Patients Coronavirus disease 19 infection telmisartan alone Angiotensin II receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Hawaii US 2020-07-01 2021-06-30 H051, NCT04360551 Phase 2 Clinical Not yet recruiting 0 12 Months 40 Cecilia M Shikuma, MD, Debra Ogata-Arakaki, RN 2020-04-27
COVIDORL: Trial Evaluating the Efficacy of Local Budesonide Therapy in the Management of Hyposmia in COVID-19 Patients Without Signs of Severity Coronavirus disease 19 infection, Olfaction disorder budesonide alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fondation Ophtalmologique Adolf De Rothschild Assistance Publique Hopitaux de Paris France 2020-04-25 2021-05-25 COVIDORL, MDL_2020_10, NCT04361474 Phase 3 Clinical Not yet recruiting 1 13 Months 120 Amélie Yavchitz, Mary DAVAL, Mary Daval 2020-04-29
NCoV: Neurocognitive Impairment in Patients With COVID-19 Cognitive disorder, Coronavirus disease 19 infection, Delirium University of Rostock Ludwig-Maximilians University of Munich, University College London Germany 2020-04-15 2021-04-01 COVID-BRAIN, NCT04359914, NCoV Phase Not Applicable Recruiting 1 11 Months 80 Gerd Klinkmann, MD, Johannes Ehler, MD 2020-04-29
STOP-COVID19: A multicenter, investigator-initiated, prospective, randomized, double-blind, placebo-controlled trial of brensocatib in patients with severe COVID-19 Coronavirus disease 19 infection brensocatib alone Dipeptidyl peptidase I inhibitor University of Dundee Insmed Inc UK STOP-COVID19 Phase 2 Clinical Status not specified 1 300 Professor James Chalmers 2020-04-27
AVINALI: Inhaled Aviptadil for the Treatment of Non-Acute Lung Injury in COVID-19 Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome aviptadil alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) NeuroRx Inc 2020-06-01 2020-10-01 AVINALI, NCT04360096, RLF-100-002 Phase 2/Phase 3 Clinical Not yet recruiting 0 4 Months 144 Jonathan C Javitt, MD, MPH, Robert E Besthof, MIM 2020-04-28
Ruxolitinib Treatment in Patients with Severe COVID-19 Infection. A Danish Safety and Efficacy Study Coronavirus disease 19 infection ruxolitinib (oral, myeloproliferative disorders), Incyte/Novartis alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zealand University Hospital Denmark 2020-04-22 2020-001459-42, 26223678Hans Phase 2 Clinical No longer recruiting 1 40 Hans Hasselbalch 2020-04-29
Isotretinoin in Treatment of COVID-19 (Randomized) Coronavirus disease 19 infection isotretinoin alone, Variable regimens including ascorbic acid , azithromycin , clarithromycin , cyanocobalamin , hydroxychloroquine , isotretinoin , lopinavir + ritonavir , oseltamivir , paracetamol Exo-alpha sialidase inhibitor, HIV protease inhibitor, Retinoic acid receptor agonist Young Adults (18-44 yrs) Tanta University Egypt 2020-04-21 2020-09-30 9469305C, NCT04361422 Phase 3 Clinical Not yet recruiting 1 5 Months 300 Lamia Elgarhy 2020-04-29
UHID-COVID19: Serum IL-6 and Soluble IL-6 Receptor in Severe COVID-19 Pneumonia Treated With Tocilizumab Coronavirus disease 19 infection, Viral pneumonia tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital for Infectious Diseases Croatia 2020-04-16 2021-04-15 NCT04359667, UHID-04, UHID-COVID19 Phase 2 Clinical Recruiting 1 12 Months 30 Arijana Pavelic, BA, Marko Kutlesa, MD, PhD, Miroslav Mayer, MD, PhD, Rok Civljak, MD, PhD 2020-04-29
COVID-19 PREVENTION: Medication for prevention of Corona-virus for Danish nursing home residents Coronavirus disease 19 infection Variable regimens including hydroxychloroquine , vitamin D , zinc Healthy volunteers accepted, Aged Adults (65-79 yrs), Elderly Adults (80 and over) Odense University Hospital Denmark 2020-04-23 2020-001363-85, 60152610‬, COVID-19 PREVENTION Phase 3 Clinical No longer recruiting 1 206 Clinical Trial Information 2020-04-29
CQOTE: Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19 Coronavirus disease 19 infection, HIV infection chloroquine alone, hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Cape Town South Africa 2020-05-01 2021-07-31 CQOTE, HIV-COVID-19 CQOTE, NCT04360759 Phase 3 Clinical Not yet recruiting 2 15 Months 560 Amy Ward, MBBCh, Bianca Sossen, MBChB, Bianca Sossen, MBChB, MSc, Bianca Sossen, MBChB, MSc), Graeme Meintjes, PhD, Jacob Standler, MBChB, Mpumi Maxebengula, BCom, Nompumelelo Maxebengula, Sean Wasserman, MBChB, Trevor Ayanda Mnguni, MBChB, FCP(SA) 2020-04-29
A Study to Explore the Role of Gut Flora in COVID-19 Infection Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) ProgenaBiome US 2020-04-16 2021-07-31 NCT04359836, PRG-041 Phase Not Applicable Recruiting 0 15 Months 250 Jordan Daniels, MS, Sabine Hazan, MD 2020-04-28
Leflunomide in Mild COVID-19 Patients Coronavirus disease 19 infection leflunomide alone Dihydroorotate dehydrogenase inhibitor, Protein tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Chicago US 2020-04-30 2020-07-31 IRB20-0622, NCT04361214 Phase 1 Clinical Not yet recruiting 0 3 Months 20 Laurencia Perea, Michael Millis, Michael Millis, MD 2020-05-02
Study of the Use of Favipiravir in Hospitalized Subjects With COVID-19 Coronavirus disease 19 infection favipiravir alone, standard of care alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fujifilm Pharmaceuticals USA, Inc US 2020-04-17 2020-12-31 FAVI-COV-US201, NCT04358549 Phase 2 Clinical Recruiting 0 8 Months 50 FPHU Study Coordinator 2020-04-29
PassItOn II: Passive Immunity Trial of Nashville II Coronavirus disease 19 infection, Respiratory tract infection pathogen reduced SARS-CoV-2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Vanderbilt University Medical Center, US US 2020-04-24 2021-04-30 200738, NCT04362176, PassItOn II Phase 3 Clinical Not yet recruiting 0 12 Months 500 Amanda J Bistran-Hall, Todd Rice, MD 2020-04-29
A phase I trial to evaluate AlloRx Stem Cells for the treatment of patients with COVID-19 infection Coronavirus disease 19 infection AlloRx Stem Cells alone Vitro Diagnostics Inc US Phase 1 Clinical Planned 0 2020-04-27
Frequency and Clinical Evolution of Olfactory and Taste Disorders in COVID-19 Patients Coronavirus disease 19 infection, Dysgeusia, Dysomia Centre Hospitalier Universitaire De Nice France 2020-03-20 2020-05-31 20ODONTOCOVID.06, NCT04361565 Phase Not Applicable Recruiting 1 2 Months 50 2020-04-29
Acral Cutaneous Thrombotic Vasculopathy and COVID-19 Infection Acrocyanosis, Coronavirus disease 19 infection, Necrosis, Purpura, Raynauds disease, Vascular disease University Hospital, Montpellier Assistance Publique Hopitaux De Marseille, Lyon-Sud Hospital Center, Marseille University Hospital France 2020-04-01 2020-10-30 NCT04361786, RECHMPL20_0211 Phase Not Applicable Recruiting 1 6 Months 10 Didier BESSIS, PhD, Léo-Paul Secco, Student 2020-04-29
PRECOVIA: Longitudinal Study of Covid-19 Infection Among HCW in a French University Hospital Coronavirus disease 19 infection SARS-Cov2 testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille Roquette Freres France 2020-04-30 2020-09-30 2020-A00950-39, 2020_34, NCT04362267, PRECOVIA Phase Not Applicable Not yet recruiting 1 5 Months 150 Annie SOBASZEK, MD, Annie SOBASZEK, MD,PhD 2020-04-29
CytokCOVID19: Pilot Study on Cytokine Filtration in COVID-19 ARDS Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia cytokine adsorption alone, sodium heparin alone, standard intensive care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinic of Barcelona Spain 2020-04-17 2020-07-31 CytokCOVID19, HCB/2020/0464, NCT04361526 Phase 2 Clinical Recruiting 1 3 Months 40 Manuel Castellà, MD PhD 2020-04-29
A multicenter, randomized, double-blind, placebo-controlled trial for Sheng-Mai-Yin for improvement of the pulmonary heart function related symptoms of convalescence patients of new coronavirus pneumonia Coronavirus disease 19 infection, Viral pneumonia shengmai decoction alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Wuhan 7th Hospital, Wuhan Hospital of Traditional Chinese Medicine, Xiaogan Traditional Chinese Medicine Hospital China 2020-04-15 2020-07-15 ChiCTR2000032205, ChiMCTR2000003235 Phase Not Applicable Not yet recruiting 3 3 Months 200 Mao Lina, Xia Ping 2020-04-29
A multicenter, randomized, double-blind, parallel-controlled trial for Qi-Mai-Fei-Luo-Ping Mixture in the improvement of lung function of novel coronavirus pneumonia (COVID-19) in the convalescent period Coronavirus disease 19 infection, Viral pneumonia Qi-Mai-Fei-Luo-Ping mixture alone, rehabilitation education guidance alone, respiratory training alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hubei province hospital of Traditional Chinese Medicine China 2020-04-01 2021-03-31 ChiCTR2000032165, ChiMCTR2000003230 Phase Not Applicable Not yet recruiting 3 12 Months 60 Xiao Mingzhong 2020-04-29
MICROVID: Bacterial and Fungal Microbiota of Patients With Severe Viral Pneumonia With COVID-19 Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille France 2020-04-30 2020-09-30 2020-A01042-37, 2020_28, MICROVID, NCT04359706 Phase Not Applicable Not yet recruiting 1 5 Months 30 Saad Nseir, MD,PhD 2020-04-30
COVID19-SETH: COVID-19 in Liver Transplant Recipients Coronavirus disease 19 infection Hospital Clinic of Barcelona Sociedad Española de Trasplante Hepático Spain 2020-03-01 2021-03-31 COVID19-SETH, HCB/2020/0384, NCT04361591 Phase Not Applicable Recruiting 1 13 Months 200 Jordi Colmenero, Jordi Colmenero, MD PhD, SETH Scientific Committee 2020-04-29
Estrogen Patch for COVID-19 Symptoms Coronavirus disease 19 infection, Viral pneumonia estradiol (transdermal patch, vasomotor symptoms/ osteoporosis), Bayer Schering alone Estradiol agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stony Brook University Hospital US 2020-04-20 2020-11-15 NCT04359329, SBU-ESTROGENPATCH-COVID19 Phase 2 Clinical Recruiting 0 6 Months 110 Alison Stopeck, MD, Andrew Handel, MD, Antonio Gasparis, MD, Christina Preece, Christina Preece, MD, Jie Yang, PhD, Patricia Thompson, Patricia Thompson, PhD, Sharon Nachman, MD 2020-04-29
A medical records based study for ECMO in the rescue therapy of extremely critical novel coronavirus pneumonia (COVID-19) patients Coronavirus disease 19 infection, Viral pneumonia ECMO alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) BaYi Brain Hospital, Children's Hospital of Chongqing Medical University China 2020-04-22 2020-05-21 ChiCTR2000032162 Phase Not Applicable Not yet recruiting 1 1 Month 80 Cao Huiling, Feng Zhichun 2020-04-29
Study for evolution and clinical outcomes study of novel coronavirus pneumonia (COVID-19) patients: a retrospective, cohort study Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tongji Hospital, Tongji Medical College National Natural Science Foundation of China China 2020-02-01 2020-06-30 ChiCTR2000032161 Phase Not Applicable Recruiting 1 5 Months 2000 Gao Qinglei, Wang Ya 2020-04-29
CORTICOVIDHUGO: Efficacy and Safety of Corticosteroids in Oxygen-dependent Patients With COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia Standard of care alone, hydrocortisone hemisuccinate alone, prednisone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Tours France 2020-05-31 2020-11-30 CORTI-COVID-19-HUGO, CORTICOVIDHUGO, DR200136, NCT04359511 Phase 3 Clinical Not yet recruiting 12 6 Months 210 BAZIN YANN, MD, GOUPIL FRANCOIS, MD, GUY TIPHAINE, MD, JOUNEAU STEPHANE, MD, PhD, LEMMENS BRUNO, MD, LIOGER BERTRAND, MD, LOUIS BERNARD, MD, PhD, MAILLOT FRANCOIS, MD, MARCHAND ADAM Sylvain, MD, PhD, MOREL HUGUES, MD, PECQUERIAUX OLIVIER, MD, POPA Mihai, MD, RABUT Thi- Tuyet Hong, MD, ROY XAVIER, MD, pascal magro, MD, sylvain marchand-adam, MD, PhD 2020-04-29
Efficacy and safety of ulinastatin in the Treatment of novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia ulinastatin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Shanghai Public Health Clinical Center China 2020-04-22 2020-12-31 ChiCTR2000032135 Phase 4 Clinical Not yet recruiting 1 8 Months 50 Hongzhou Lu, Yun Ling 2020-04-30
HBOTCOVID19: Hyperbaric Oxygen Therapy Effect in COVID-19 RCT Coronavirus disease 19 infection, Respiratory insufficiency hyperbaric oxygen therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assaf-Harofeh Medical Center 2020-04-26 2020-07-30 120-20-ASF, HBOTCOVID19, NCT04358926 Phase Not Applicable Not yet recruiting 0 3 Months 30 Amir Hadanny, MD, Shai Efrati, MD 2020-04-30
The effect of pomegranate tea on symptom relief of COVID-19 patients: a double-blind, randomized clinical trial study Coronavirus disease 19 infection, Viral pneumonia pomegranate tea alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahrekord University of Medical Sciences and Health Services Iran 2020-04-20 IR.SKUMS.REC.1399.017, IRCT20200416047104N1 Phase Not Applicable Recruiting 1 66 Dr. Fereidoun Rahmani, Dr. Mehraban Sadeghi, Dr. Zahra Lorigooini, Dr. Zohreh Abolhassanzadeh, Vahid Reisi-Vanani 2020-04-29
TX-COVID: Solid Organ Transplant Recipients With Covid-19 French Registry Coronavirus disease 19 infection Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-04-08 2021-04-08 7766, NCT04360707, TX-COVID Phase Not Applicable Recruiting 1 12 Months 300 Gabriela GAUTIER, MD, Samira FAFI-KREMER, MD, PhD, Saïd CHAYER, PhD, HDR, Sophie CAILLARD, MD, PhD 2020-04-29
COVID-DEX: Dexmedetomidine to Improve Outcomes of ARDS in Critical Care COVID-19 Patients Coronavirus disease 19 infection, Pulmonary edema, Respiratory distress syndrome, Respiratory insufficiency Variable regimens including dexmedetomidine , propofol, AstraZeneca/Fresenius , remifentanil Alpha 2 adrenoceptor agonist, Opioid receptor mu agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinic of Barcelona Spain 2020-04-15 2020-06-30 COVID-DEX, NCT04358627, SPEC-M, SPEC-M COVID-19 Phase Not Applicable Not yet recruiting 1 2 Months 80 Pedro L Gambus, PhD MD, Xavier Borrat, PhD MD 2020-04-29
CIPOLLINI: Nasal Epithelial Genetic and Single Cell RNA COVID-19 Study Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Medical Center Groningen Netherlands 2020-06-30 2022-06-30 CIPOLLINI, CIPOLLINI, NCT04359459 Phase Not Applicable Not yet recruiting 1 24 Months 150 Daan Pouwels, PhD, Dirk-Jan Slebos, MD PhD, Janesh Pillay, MD PhD, Maarten van den Berge, Maarten van den Berge, MD PhD 2020-04-29
Examination of test accuracy of COVID-19 rapid antibody kit Coronavirus disease 19 infection rapid antibody kit alone Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ja Akita Koseiren Omagari Kosei Medical Care Center Japan 2020-04-23 UMIN000040235 Phase Not Applicable Recruiting 1 20 Toshiki Horii 2020-04-29
COCARDE: Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients Coronavirus disease 19 infection, Myocardial disease transthoracic echocardiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-04-04 2020-11-04 2020-A00852-37, COCARDE, NCT04358952, RC31/20/0117 Phase Not Applicable Recruiting 1 7 Months 50 Olivier LAIREZ, PU-PH, Vincent MINVILLE, PU PH, Vincent MINVILLE, PU-PH 2020-04-29
Targeted Steroids for ARDS Due to COVID-19 Pneumonia: A Pilot, Randomized Clinical Trial Adult respiratory distress syndrome, Coronavirus disease 19 infection, Viral pneumonia dexamethasone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Colorado at Denver and Health Sciences Center 2020-05-01 2020-12-31 20-0811, NCT04360876 Phase 2a Clinical Not yet recruiting 0 8 Months 90 2020-04-29
Database for diagnosis and therapy of COVID-19 infected patients Coronavirus disease 19 infection data collection alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The Institute for Research in Operative Medicine Germany 2020-04-26 75/2020, DRKS00021514 Phase Not Applicable Not yet recruiting 1 150 Sarah Schwarz, Tim Mathes 2020-04-29
Quercetin in COVID-19 Coronavirus disease 19 infection quercetin alone, routine drug therapy alone Ahvaz University of Medical Sciences Iran 2020-04-29 IR.AJUMS.REC.1399.087, IRCT20200419047128N2 Phase 3 Clinical Recruiting 1 60 Ali khodadadi, Mohamad Badavi, َAli Khodadadi 2020-04-30
Evaluation of the effects of Sitagliptin administration in patients with COVID-19 Coronavirus disease 19 infection Variable regimens including hydroxychloroquine , lopinavir + ritonavir , sitagliptin (Dr. Abidi Pharmaceuticals) HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-05-04 IR.SBMU.NRITLD.REC.1399.029, IRCT20200420047147N1 Phase 2/Phase 3 Clinical Not yet recruiting 1 84 Afshin Zarghi, Ahad Zare, Dr. Atefe Abedini, Farzaneh Dastan 2020-04-29
Effect of NK cell therapy in COVID-19 Coronavirus disease 19 infection, Viral pneumonia allogeneic natural killer cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Middle East Gene Therapy corporation Iran 2020-04-27 IR.TUMS.VCR.REC.1399.069, IRCT20200417047113N1 Phase 1/Phase 2 Clinical Recruiting 1 70 Minoo Mohraz, Sahar Shojaei 2020-04-29
Performance Evaluation of BCG Vaccination in Healthcare Personnel to Reduce the Severity of SARS-COV-2 Infection Coronavirus disease 19 infection vaccine BCG alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Universidad de Antioquia Colombia 2020-04-30 2021-11-30 NCT04362124, PEC03_2020 Phase 3 Clinical Not yet recruiting 1 19 Months 1000 Juan C Cataño, MD.MI.ID, Juan C cataño, MD.MI.ID, Liliana Lopez, BSc.MSc 2020-04-29
Classification of COVID-19 Infection in Posteroanterior Chest X-rays Coronavirus disease 19 infection DenseNet121 alone, PCX images (chest X-rays) alone, VGG16 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dascena US 2020-04-01 2020-04-17 04202002, NCT04358536 Phase Not Applicable Completed 0 230 2020-04-29
Baricitinib Therapy in COVID-19 Coronavirus disease 19 infection, Viral pneumonia baricitinib plus lopinavir + ritonavir HIV protease inhibitor, Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ospedale Misericordia e Dolce Italy 2020-03-16 2020-04-07 HPRATO-4, NCT04358614 Phase 2/Phase 3 Clinical Completed 1 12 Fabrizio Cantini 2020-04-29
A clinical study of CLBS-119 for repair of COVID-19 induced lung damage in patients with severe SARS-CoV-2 infection that required ventilatory support due to respiratory failure Coronavirus disease 19 infection, Lung injury, Respiratory failure CLBS-119 alone Caladrius Biosciences Inc US Phase Not Applicable Not yet recruiting 0 2020-04-28
Efficacy and Safety Study of Allogeneic HB-adMSCs for the Treatment of COVID-19 Coronavirus disease 19 infection autologous adipose-derived mesenchymal stem cells (iv infusion, rheumatoid arthritis), Hope Biosciences alone, Variable regimens including autologous adipose-derived mesenchymal stem cells (iv infusion, rheumatoid arthritis), Hope Biosciences , azithromycin , hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hope Biosciences Inc Advanced Diagnostics Healthcare, Hope Biosciences Stem Cell Research Foundation US 2020-05-15 2020-10-31 ALLOGENEIC TREATMENT COVID-19, NCT04362189 Phase 2 Clinical Not yet recruiting 0 5 Months 110 Joseph Gathe, MD, FACP, Katherine Ruppert, PhD, Mariann England, Rajiv Thakur, MD, Sherry Diers, RN, Thinh Vo, MD 2020-04-29
A phase III confirmatory study to evaluate the safety and efficacy of Bucillamine for the treatment of patients with mild-moderate COVID-19 due to the SARS-CoV-2 infection Coronavirus disease 19 infection repurposed formulation of bucillamine (gout/cystinuria/Wilson disease), Revive Therapeutics alone Xanthine oxidase inhibitor Pharm-Olam International, Revive Therapeutics Ltd Canada Phase 3 Clinical Planned 1 Dr. Kelly McKee, Jr., MD, MPH 2020-04-30
A clinical trial of Mitotech-19 for the treatment of acute respiratory distress syndrome in patients with COVID-19 infection Coronavirus disease 19 infection, Respiratory distress syndrome Mitotech-19 alone Mitotech SA Phase Not Applicable Planned 0 2020-04-28
RUXCOVID: Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Ruxolitinib in Patients With COVID-19 Associated Cytokine Storm Coronavirus disease 19 infection, Viral pneumonia ruxolitinib (oral, myeloproliferative disorders), Incyte/Novartis alone, standard-of-care alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Novartis AG Incyte Corp Germany 2020-04-30 2020-06-29 2020-001662-11, CINC424J12301, INCB 18424-368, NCT04362137, RUXCOVID Phase 3 Clinical Recruiting 1 2 Months 402 Medizinischer Infoservice (MCC), Novartis Pharmaceuticals 2020-04-29
Adaptive, multicenter, randomized, open, comparative clinical trial of the efficacy and safety of the drug favipiravir in patients hospitalized with COVID-19 Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Kromis LLC Russian Federation 2020-04-23 2020-12-31 COVID-FPR-01 Phase 3 Clinical Status not specified 17 8 Months 390 2020-04-25
CORONA: A multicenter, randomized, double-blind, placebo-controlled, adaptively designed clinical trial of the efficacy and safety of levilimab (BCD-089) in patients with severe COVID-19 Coronavirus disease 19 infection BCD-089 alone IL-6 receptor antagonist Biocad Ltd Russian Federation 2020-04-22 2022-12-30 BCD-089-4, CORONA Phase 3 Clinical Status not specified 4 32 Months 250 2020-04-25
A clinical trial of convalescent plasma for the treatment of COVID-19 infection Coronavirus disease 19 infection onvalescent plasma alone Healthy volunteers accepted Viravaxx AG Phase Not Applicable Not yet recruiting 0 600 2020-04-24
Study of Shreepad Shree Vallabh SSV Formulation to improve immunity in quarantine patients of COVID-19 Coronavirus disease 19 infection, Immunization SSV Formulation tablet alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) SSV Phytopharmaceuticals India 2020-04-27 CTRI/2020/04/024659, Protocol No. SSV-SF-04/2020 Phase 3 Clinical Not yet recruiting 1 30 Dr Samadhan Patil, Dr Yogesh Dound 2020-04-28
RTLS Technology Study Coronavirus disease 19 infection Real Time Location System alone The Royal Wolverhampton Hospitals Nhs Trust Cornell University, La Trobe University UK 2020-01-06 2020-12-31 2019SUR107, NCT04114110 Phase Not Applicable No longer recruiting 1 11 Months 2000 2020-04-27
CONCOR-1: Convalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness Coronavirus disease 19 infection Convalescent plasma alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hamilton Health Sciences Corp, Hema-Quebec Canadian Blood Services, McMaster University, Universite De Montreal, University of Toronto Canada 2020-04-27 2020-12-31 CONCOR-1, CONCOR-1, NCT04348656 Phase 3 Clinical Not yet recruiting 27 8 Months 1200 Andrew Shih, Anne-Sophie Lemay, Arjuna Ponnampalam, Benjamin Rioux-Masse, Brian Berry, Christine Cserti, Danielle Talbot, David Welbourne, Donald M Arnold, MD, Erin B Jamula, MSc., Jacob Pendergrast, Julie Rousseau, Katerina Pavenski, Luigina Mollica, Menaka Pai, Michelle Zeller, Nadine Shehata, Patrice Beauregard, Patricia Pelletier, Shuoyan Ning, Stephen Caplan, Susan Nahirniak, Tony Giulivi, Valerie Arsenault, Vincent Laroche, Yulia Lin, Ziad Solh 2020-04-30
PRA-001: Plasma Rich Antibodies From Recovered Patients From COVID19 Coronavirus disease 19 infection Variable regimens including Antibody-Rich Plasma , azithromycin , hydroxychroquine , oseltamivir Exo-alpha sialidase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ain Shams University Egypt 2020-04-20 2020-12-31 FMASU P15/ 2020, NCT04348877, PRA-001 Phase 2 Clinical Not yet recruiting 1 8 Months 20 Hossam Fahmy, Professor of Faculty of Medicine 2020-04-27
WAVES: Airway Pressure Release Ventilation for mechanically ventilated patients with COVID-19 in Western Australian Intensive Care Units: an observational study Coronavirus disease 19 infection Airway pressure release ventilation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sir Charles Gairdner Hospital Australia 2020-04-27 ACTRN12620000474954p, WAVES Phase Not Applicable Not yet recruiting 8 100 A/Prof Matthew Anstey 2020-04-30
COVID RASP: Reducing acute severe respiratory events in health care workers during the Covid-19 pandemic with OM-85 Coronavirus disease 19 infection, Respiratory disease OM-85 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Queensland Australian Government Australia 2020-06-01 2020-07-31 ACTRN12620000473965p, BV-2020/19, COVID RASP, U1111-1250-2920 Phase 3 Clinical Not yet recruiting 3 2 Months 1000 Mrs Sharon Brabon, Prof Peter Sly 2020-04-28
An investigator initiated study to test COVID-19 pneumonia patients with Unyvero HPN panel for bacterial co-infections Bacterial infection, Coronavirus disease 19 infection, Viral pneumonia Unyvero system alone Karolinska Institutet OpGen Inc Sweden 2020-04-21 Phase Not Applicable Recruiting 1 2020-04-24
Effectiveness of Measles Vaccine in Health Care Professionals During COVID-19 Outbreak (Randomized Controlled Trial) Coronavirus disease 19 infection Measles Mumps and Rubella vaccine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Misr University for Science and Technology Kasr Alainy School of Medicine Egypt 2020-04-15 PACTR202004693933092 Phase 2 Clinical Not yet recruiting 1 200 Ahmed Mukhtar, Mahmoud Nassar, Mostafa Alfishawy 2020-04-27
COVIPOC: Senicapoc in COVID-19 Patients with Severe Respiratory Insufficiency – A Randomized, Open-Label, Phase II Trial Coronavirus disease 19 infection, Respiratory insufficiency senicapoc alone KCNN potassium channel-4 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aarhus University Denmark 2020-04-14 0001, 2020-001420-34, COVIPOC Phase 2 Clinical Recruiting 1 www.Clinicaltrials.gov 2020-04-27
A phase I clinical study to assess ABL novel prophylactic COVID-19 vaccine and to analyze biomarker to characterize the immune profile of subjects participating in the study Coronavirus disease 19 infection ABL novel prophylactic COVID-19 vaccine alone Advanced BioScience Laboratories Inc Institut Merieux SA Phase 1 Clinical Planned 0 2020-04-27
Efficacy and safety of IHP Detox Tea (a special blend of Andrographis paniculata, Garcinia kola and Psidium guajava) for treatment of Corona virus disease 2019 (COVID-19): a pilot placebo-controlled randomized trial Coronavirus disease 19 infection IHP Detox Tea alone, conventional therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Neimeth International Pharmaceuticals Plc Nigeria 2020-05-01 PACTR202004761408382 Phase Not Applicable Not yet recruiting 2 72 Charles Esimone, George Eleje, Jude Duru 2020-04-29
A diagnostic study IgG and/or IgM antibodies to the SARS-CoV-2 (novel 2019 coronavirus) through ZEUS's lateral flow test Coronavirus disease 19 infection ZEUS's lateral flow test alone Healthy volunteers accepted Zeus Scientific Inc US, China Phase Not Applicable Status not specified 1 2020-04-24
A medical records based study for 'Guangdong Pneumonia NO.1' in the Treatment of Novel Coronavirus Pneumonia (COVID-19) Coronavirus disease 19 infection, Pneumonia Guangdong Pneumonia NO.1 alone, basic treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Guangzhou Hospital China 2020-02-11 2020-11-30 ChiCTR2000031888, ChiMCTR2000003208 Phase Not Applicable Recruiting 3 9 Months 300 Liansheng Lin, Luping Lin 2020-04-27
A phase II clinical study of stem cells to treat hospitalized patients with COVID-19 infection Coronavirus disease 19 infection stem cells alone Personalized Stem Cells Inc Phase 2 Clinical Planned 0 2020-04-24
A study of Wondfo SARS-CoV-2A point of care test for the diagnosis of COVID-19 Coronavirus disease 19 infection Wondfo SARS-CoV-2A point of care test alone Guangzhou Wondfo Biotech Co Ltd Phase Not Applicable Status not specified 0 2020-04-24
A validation study of Wondfo SARS-CoV-2A point of care test for the diagnosis of COVID-19 Coronavirus disease 19 infection Wondfo SARS-CoV-2A point of care test alone National Institute of Virology Cellmid Ltd, World Health Organization India 2020-04-22 Phase Not Applicable Completed 1 36 2020-04-24
A phase IIa, multicenter clinical trial of Cannabidiol-Steroid formulation for the treatment of COVID-19 infection Coronavirus disease 19 infection cannabidiol-steroid alone Stero Biotechs Ltd Phase 2a Clinical Planned 0 40 2020-04-25
An IP Protected Cliniacl Trial of Cannabidiol- steroid formulation for the treatment of COVID-19 infection Coronavirus disease 19 infection cannabidiol- steroid alone Stero Biotechs Ltd Mor Research Applications Ltd Israel 2020-04-30 Phase Not Applicable Planned 1 10 2020-04-25
Prophylaxis of COVID-19 infection with hydroxychloroquine in healthcare personnel with high risk of infection Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Mútua Terrassa University Hospital Spain 2020-04-18 2020-001536-98, PREPSARS Phase 3 Clinical Recruiting 1 300 HOSPITAL UNIVERSITARI MUTUA TERRASSA, INTERNAL MEDICINE DEPARTMENT 2020-04-27
Study to investigate the safety and effects of vaccines in healthy adults Coronavirus disease 19 infection BNT-162a1 alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) BioNTech SE Pfizer Inc Germany 2020-04-20 2020-001038-36, BNT162-01, U1111-1249-4220 Phase 1/Phase 2 Clinical Recruiting 1 196 Clinical Study Management 2020-04-30
A trial to evaluate BNT-162 for the prevention of COVID-19 infection Coronavirus disease 19 infection BNT-162a1 alone COVID19 Spike glycoprotein modulator BioNTech SE Pfizer Inc US Phase Not Applicable Planned 0 2020-04-30
CIGB-2020 in contacts and suspects of SARS-CoV-2 infection Coronavirus disease 19 infection CIGB-2020 alone, conventional treatment alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Genetic Engineering and Biotechnology Instituto Pedro Kouri Cuba 2020-03-27 2020-06-30 CIGB 2020-01, RPCEC00000306 Phase 1/Phase 2 Clinical Recruiting 1 3 Months 80 Julia Cuesta Diéguez, Zurina Cinza Estévez 2020-04-27
PrevenCOVID-19: Study for the prevention of COVID-19 infection in healthcare personnel Coronavirus disease 19 infection hydroxychloroquine (Dolquine) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Fundación Pública Andaluza Para La Gestión De La Investigación En Salud De Sevilla Spain 2020-04-19 2020-001440-26, PrevenCOVID-19, PrevenCOVID-19 Phase 3 Clinical Recruiting 1 184 CTU-HUVR, Clinical trial information 2020-04-27
TAC-COVID19: Outpatient Treatment Of Covid-19 With Early Pulmonary Corticosteroids As An Opportunity To Modify The Course Of The Disease Coronavirus disease 19 infection Variable regimens including azithromycin , hydroxychloroquine , paracetamol , prednisone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hospital San Juan de Dios Burgos Hospital Universitario de Burgos Spain 2020-04-19 2020-001622-64, TAC-COVID19, TAC-COVID19 Phase 4 Clinical Recruiting 1 200 María Jesús Coma 2020-04-28
COVID-Aging: Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on the Survival of Hospitalized Elderly Patients With COVID-19 Coronavirus disease 19 infection Variable regimens including azithromycin , hydroxychloroquine , telmisartan Angiotensin II receptor antagonist Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-04-24 2021-06-01 2020-001303-16, 7747, COVID-Aging, NCT04359953 Phase 3 Clinical Recruiting 2 13 Months 1600 Frédéric BLANC, Frédéric BLANC, MD 2020-04-29
CAPACoV19: Long Term Physical Functional Limitations in Daily Living in SARS-CoV2 Infected Patients Hospitalized in the Acute Phase Then Requiring Rehabilitation Coronavirus disease 19 infection data record alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Reims France 2020-05-01 2022-02-01 CAPACoV19, NCT04356378, PO20055 Phase Not Applicable Not yet recruiting 1 21 Months 300 Francois BOYER, François BOYER 2020-04-27
Efficacy of Tocilizumab on Patients With COVID-19 Coronavirus disease 19 infection, Hypoxia, Respiratory failure tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Massachusetts General Hospital Genentech Inc US 2020-04-27 2020-08-30 2020P001159, NCT04356937 Phase 3 Clinical Not yet recruiting 0 4 Months 300 Ana D Fernandes, MA, John H Stone, MD, John H Stone, MD,MPH 2020-04-27
CORONA-SHIELD: Assessing the System for High-Intensity Evaluation During Radiotherapy During Changes in Response to COVID-19 Coronavirus disease 19 infection radiation therapy alone, telehealth alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Duke University US 2020-04-14 2021-04-30 CORONA-SHIELD, NCT04357574, PRO00105266 Phase Not Applicable Recruiting 0 12 Months 1000 Manisha Palta, MD 2020-04-24
COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1 Coronavirus disease 19 infection, Respiratory failure best supportive care alone, nivolumab alone Programmed cell death protein 1 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Queen Mary Hospital The University of Hong Kong Hong Kong 2020-04-14 2021-08-31 NCT04356508, UW20213 Phase 2 Clinical Not yet recruiting 1 16 Months 15 Gerry Gin Wai Kwok, MBBS 2020-04-23
A phase II, randomized, double-blind, placebo-controlled clinical study to evaluate the safety and preliminary efficacy of ATYR-1923 in confirmed COVID-19 positive patients with severe respiratory complications Coronavirus disease 19 infection ATYR-1923 alone Neuropilin 2 inhibitor aTyr Pharma Inc US Phase 2 Clinical Not yet recruiting 0 30 2020-04-23
A Single-blinded, Randomized, Placebo-Controlled, Phase II Trial of Prophylactic Treatment With Oral Azithromycin Versus Placebo in Cancer Patients Undergoing Antineoplastic Treatment During the Corona Virus Disease 19 (COVID-19) Pandemic Coronavirus disease 19 infection azithromycin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical University of Vienna Austria 2020-04-27 2020-12-27 2020-001327-13, NCT04369365, OnCoVID-19 Trial Phase 2 Clinical Recruiting 1 8 Months 200 Marika Rosner, Matthias Preusser, MD, Prof. Dr. Matthias Preusser 2020-05-01
A clinical study evaluate the safety and efficacy of combination of chloroquine with azithromycin and interferon beta-1b, to prevent admission to intensive care, mechanical ventilation and/or death to combat COVID-19 Coronavirus disease 19 infection Variable regimens including azithromycin , chloroquine , interferon beta-1b, Bayer Interferon beta ligand Bayer Inc, Population Health Research Institute Canada Phase Not Applicable Planned 1 2020-04-23
MV-COVID19: Measles Vaccine in HCW Coronavirus disease 19 infection measles, mumps, rubella vaccine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Kasr El Aini Hospital Egypt 2020-05-01 2020-11-01 MV-COVID19, N-20-2020, NCT04357028 Phase 3 Clinical Not yet recruiting 2 6 Months 200 Abeer Ahmed, MD, Ahmed M Mukhtar, M.D, Doaa Ghaith, MD, Marwa Rashad, MD, Mostafa Alfishawy, MD 2020-04-24
A pilot study to assess the effect of beta-nicotinamide mononucleotide (NMN) in the prevention/treatment of patients with Covid-19 Coronavirus disease 19 infection beta-nicotinamide mononucleotide alone Shinkowa Pharmaceutical Co Ltd Phase Not Applicable Planned 0 2020-04-23
Immune Response to Covid-19 in 300 Health Care Workers With Mild Symptoms Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Sciensano Jessa Hospital Belgium 2020-04-30 2020-07-30 JESSA300, NCT04356586 Phase Not Applicable Recruiting 2 3 Months 300 Maria Goossens, MD, PhD 2020-04-24
Feasibility, early intervention, chinese herbal treatment, addition to standard of care, COVID-19 Coronavirus disease 19 infection Chinese herbal treatment alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sunway TCM Centre Malaysia 2020-05-01 2020-10-30 54625, NMRR-20-759-54625 Phase Not Applicable Status not specified 1 5 Months 100 Dr LIM REN JYE, Dr Lee Yee Leng 2020-04-24
PACA: Nebulized Rt-PA for ARDS Due to COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome invasive mechanical ventilation alone, nebulized recombinant tissue-plasminogen activator (rt-PA) alone, non-invasive ventilation alone, standard of care alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University College London UK 2020-04-22 2021-01-14 132151, NCT04356833, PACA Phase 2 Clinical Recruiting 1 8 Months 24 Mark Phillips, Pratima Chowdary 2020-05-01
SCout: Risk Stratification With Chest CT to Rule-out Suspected SARS-CoV-2 Infections Coronavirus disease 19 infection, Viral pneumonia CT-imaging alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jena University Hospital Germany 2020-04-15 2020-04-30 IDIR-001-2020, NCT04357938, SCout Phase Not Applicable No longer recruiting 1 145 Ulf Teichgräber, Prof. Dr. 2020-04-23
RISC-19-ICU: The Risk Stratification in COVID-19 Patients in the ICU Registry Coronavirus disease 19 infection standard of care alone University of Zurich Switzerland 2020-03-13 2022-03-31 KEK-ZH-REQ-2020-00322, NCT04357275, RISC-19-ICU Phase Not Applicable Recruiting 1 24 Months 10000 Dorothea Heuberger, PhD, Jonathan Montomoli, MD, PhD, Matthias P Hilty, MD, Pedro D Wendel Garcia, MSc, Philippe Guerci, MD, Reto A Schüpbach, MD, Theirry Fumeaux, MD 2020-04-23
MODIF: Myocardial Infarction Rates Overview During COVID-19 Pandemic In France Coronavirus disease 19 infection, Myocardial infarction Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Société Française de Cardiologie INSERM France 2020-04-27 2020-07-31 2020-03, MODIF, NCT04357314 Phase Not Applicable Not yet recruiting 1 3 Months 80 Guillaume BONNET, MD, Guillaume CAYLA, MD, Tessa BERGOT 2020-04-23
COVIP: Impact of Long-term Protease Inhibitors in Patients Living With HIV on the Incidence of COVID-19 Coronavirus disease 19 infection, HIV-1 infection, HIV-2 infection antiretroviral therapy alone, protease inhibitor therapy alone, usual care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Intercommunal Creteil Centre Hospitalier Intercommunal Villeneuve Saint Georges, Service des Urgences France 2020-04-30 2020-10-31 COVIP, COVIP, NCT04357639 Phase Not Applicable Not yet recruiting 5 6 Months 794 Alice RAFFETIN, MD, GARRAIT Valérie, MD, Gallien Sebastien, MD, Raffetin Alice, MD, SALMON Dominique, MD, Vignier Nicolas, MD 2020-04-27
Hydroxychloroquine Monotherapy and in Combination With Azithromycin in Patients With Moderate and Severe COVID-19 Disease Coronavirus disease 19 infection, Viral pneumonia azithromycin plus hydroxychloroquine (JWT-629) Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Novartis AG 2020-04-30 2020-07-21 CJWT629A12301, NCT04358081 Phase 3 Clinical Not yet recruiting 0 2 Months 444 Novartis Pharmaceuticals 2020-04-30
AVoCaDO: Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Respiratory failure ascorbic acid alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hunter Holmes Mcguire Veteran Affairs Medical Center Mcguire Research Institute Inc US 2020-04-16 2020-08-01 AVoCaDO, DAVIS 001, NCT04357782 Phase 1/Phase 2 Clinical Recruiting 0 3 Months 20 Brian C Davis, MD 2020-04-23
COVID-19 Among Egyptian Health Care Providers Coronavirus disease 19 infection online self-administered questionnaire alone Assiut University Egypt 2020-04-30 2020-05-31 COVIDQ, NCT04357431 Phase Not Applicable Not yet recruiting 1 1 Month 600 Ahmed Mohamed Abbas 2020-04-23
WAVE: Wearable-based COVID-19 Markers for Prediction of Clinical Trajectories Coronavirus disease 19 infection smartwatch alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Inselspital, Berne ETH Zurich Switzerland 2020-05-01 2020-07-31 NCT04357834, WAVE, WAVE Phase Not Applicable Not yet recruiting 1 3 Months 100 Aristomenis Extradaktylos, Prof. MD, David D Srivastava, MD, MBA, David Srivastava, MD, MBA 2020-04-29
COPLASCOV19: Convalescent Plasma For Ill Patients By COVID-19 Coronavirus disease 19 infection, Respiratory disease, Viral pneumonia convalescent plasma alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto De Seguridad Y Servicios Sociales De Los Trabajadores Del Estado Angeles Chihuahua Hospital, GENERAL HOSPITAL OF THE STATE OF SONORA, HOSPITAL CENTRAL NACIONAL PEMEX NORTE, HOSPITAL DE ZONA No.14 IMSS, IMSS General Hospital of Zone 2A "Troncoso", SECRETARIA DE SALUD DEL ESTADO DE SONORA Mexico 2020-05-31 2020-12-31 COPLASCOV19, NCT04356482, TERAPLASCOV2 Phase 1/Phase 2 Clinical Not yet recruiting 5 7 Months 90 CARLOS BEST, MD, Carlos Martinez-Murillo, MD, Diego Espinoza, MD, FERNANDO PEREZ-JACOBO, MD, LUIS villela, MD, Luis M Villela, MD, Luis Villela, MD,MSc, Melani Otañez, MD 2020-04-29
Sarilumab treatment in cytokine storm caused by infection with COVID-19 Coronavirus disease 19 infection, Respiratory failure sarilumab alone IL-6 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clinica Universidad de Navarra Spain 2020-04-16 2020-001255-40, STRIKE-SARS-CoV2 Phase 2 Clinical No longer recruiting 1 60 UCEC 2020-04-29
Covid-Thelium: Assessment of Endothelial and Hemostatic Changes During Severe SARS-CoV-2 Infection Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Boisguillaume France 2020-04-09 2020-08-31 2020/097/OB, Covid-Thelium, NCT04357847 Phase Not Applicable Recruiting 1 4 Months 100 EBESNIER, emmanuel besnier, MD, thomas clavier, MD, PhD 2020-04-27
SARICOR: Clinical Trial of Sarilumab in Adults With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome best available treatment alone, sarilumab alone IL-6 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Maimonides Biomedical Research Institute of Cordoba Consejeria de Salud. Junta de Andalucia Spain 2020-04-18 2020-07-27 2020-001531-27, NCT04357860, SARICOR, SARICOR Phase 2 Clinical Recruiting 1 3 Months 120 Antonio Luque, José Carlos Garrido Gracia, Julián de la Torre Cisneros, MD, Rafael León López, MD 2020-04-28
COVID-TGT: Analysis of the Coagulopathy Developed by COVID-19 Infected Patients Coronavirus disease 19 infection fibrin generation markers assays alone, thrombin generation test assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Nimes France 2020-04-30 2021-01-31 COVID-TGT, NCT04356950, PHRC-I/2020/JCG-01 Phase Not Applicable Not yet recruiting 4 9 Months 175 Albert Sotto, Anissa Megzari, Antonia Perez Martin, Catherine Lechiche, Charles Cazenave, Claire Roger, Claudine Barbuat, Didier Laureillard, Isabelle Quere, Jean-Christophe Gris, Jean-François Faucher, Jean-Marc Mauboussin, Jean-Yves Lefrant, Kada Klouche, Laurent Muller, Paul Loubet, Saber D Barbar, Vincent Le Moing 2020-04-30
Plasma Adsorption in Patients With Confirmed COVID-19 Coronavirus disease 19 infection D2000 plasma adsorption cartridge alone, Optia secondary plasma device alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Marker Therapeutics AG 2020-04-27 2020-12-01 MH-007/B, NCT04358003 Phase Not Applicable Not yet recruiting 0 7 Months 2000 Eeke Romo, MD 2020-04-25
Registry of Hospitalized Pediatric Patients with SARS-CoV-2 Infection (COVID-19) Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) University Hospital Carl Gustav Carus Germany 2020-03-18 BO-EK-110032020, DRKS00021506 Phase Not Applicable Recruiting 1 1000 Jakob Armann 2020-04-24
Evaluating the Efficacy of Hydroxychloroquine and Azithromycin to Prevent Hospitalization or Death in Persons With COVID-19 Coronavirus disease 19 infection azithromycin plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institute of Allergy and Infectious Diseases Teva Pharmaceutical Industries Ltd 2020-05-01 2021-03-05 38720, ACTG A5395, NCT04358068 Phase 2b Clinical Not yet recruiting 0 10 Months 2000 Davey Smith, MD 2020-05-01
ICOS: Psychological Outcome of COVID-19 Lockdown on Psychiatric Hospital Staff and Close Relatives Anxiety disorder, Coronavirus disease 19 infection, Depression, Psychiatric disorder survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre hospitalier de Ville-Evrard France 2020-04-01 2020-06-30 10477M-ICOS, ICOS, NCT04357418 Phase Not Applicable No longer recruiting 1 3 Months 1320 Clemence ISAAC, PhD, Dominique JANUEL, Pr 2020-04-29
Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections Coronavirus disease 19 infection thrombin generation assay alone, thrombomodulin-modified thrombin generation assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical University of Vienna Medizinisch-Wissenschaftlicher Fonds des Burgermeisters der Bundeshauptstadt Wien Austria 2020-04-17 2020-12-01 NCT04356144, TGA-TM-CRITICAL-2019 Phase Not Applicable Not yet recruiting 1 7 Months 60 Lukas Infanger, Lukas Infanger, MD, Marion Wiegele, MD 2020-04-24
Dysosmia and Dysgeusia in COVID-19 patients Coronavirus disease 19 infection, Dysgeusia, Dysomia smell and taste test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kantonsspital Aarau Switzerland 2020-04-22 2020-00666, DRKS00021516 Phase Not Applicable Recruiting 1 100 Thirza Singer-Cornelius 2020-04-27
Evaluation of the efficacy and safety of methylprednisolone pulse therapy in treatment of Covid-19 patients with Acute respiratory distress syndrome Coronavirus disease 19 infection methylprednisolone pulse therapy alone, hydroxychloroquine plus methylprednisolone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Artesh University of Medical Sciences Iran 2020-03-30 IR.AJAUMS.REC.1399.008, IRCT20200406046963N1 Phase 3 Clinical Recruiting 1 40 Ebrahim Hazrati, Ebrahim hazrati, Ramin Hamidi Farahani, Reza Mosaed 2020-04-24
A prospective, single-center, parallel-group, open-label, randomized clinical trial to assess the efficacy of CPAP in 200 COVID-19 confirmed or suspected patients within the Mount Sinai Health System with respiratory symptoms Coronavirus disease 19 infection, Obstructive sleep apnea CPAP alone, WatchPAT ONE alone Itamar Medical (Cm) 1997 Ltd US Phase 2 Clinical Status not specified 0 200 Neomi Shah 2020-04-27
What’s the STORY?: A pilot, multi-site, UK immunization program to assess novel coronavirus infection (COVID-19) rates in children and teenagers across the UK Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) University of Oxford United Kingdom Research & Innovation UK What’s the STORY? Phase Not Applicable Recruiting 1 1200 Professor Matthew Snape 2020-04-23
A compassionate use program of Ruconest in hospitalized patients with confirmed COVID-19 infections suffering from related severe pneumonia who did not improve despite standard treatment, including hydroxychloroquine and lopinavir/ritonavir Coronavirus disease 19 infection, Viral pneumonia conestat alfa alone Complement C1s subcomponent inhibitor, Kallikrein modulator, Mannan-binding lectin serine protease inhibitor Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Pharming Group NV Switzerland Phase 2 Clinical Status not specified 1 5 2020-04-23
Rapid Salivary Test to Detect SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection rapid salivary test alone Healthy volunteers accepted Università degli Studi dell'Insubria Italy 2020-04-16 2020-07-31 68/2020, NCT04357327 Phase Not Applicable Recruiting 1 3 Months 100 Lorenzo Azzi, Lorenzo Azzi, DDS 2020-04-27
Comparison of New Coronavirus (Covid-19) Awareness in Individuals of Different Age Groups: Analysis of Turkey Coronavirus disease 19 infection Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istanbul University-Cerrahpasa Turkey 2020-05-31 2020-06-30 60350273-605.99-, NCT04357886 Phase Not Applicable Not yet recruiting 1 1 Month 1000 Aysenur Erekdag, Student, Ipek Yeldan, PhD, Saliha Gurdal Karakelle, MSc 2020-04-27
CoVS: COVID-19 Survey Study on Dietary Intake, Physical Activity and Overall Well-being Coronavirus disease 19 infection staying home alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Illinois Institute of Technology US 2020-04-17 2021-04-30 CoVS, IRB-2020-91, NCT04357041 Phase Not Applicable Recruiting 0 12 Months 500 Britt Burton-Freeman, Ph.D, Di Xiao, MAS, Indika Edirisinghe, Ph.D 2020-04-30
PSYCHIC: Psychiatric Disorders and Covid-19 Coronavirus disease 19 infection, Post traumatic stress disorder, Psychiatric disorder Brief Psychiatric Rating Scale alone, Connor-Davidson Resilience Scale 10 items (CD-RISC 10) alone, Impact of Event Scale-Revised alone, depression, Anxiety and Stress Scale alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CHU De Nantes France 2020-04-25 2023-01-01 NCT04358042, PSYCHIC, RC20-0165 Phase Not Applicable Not yet recruiting 1 32 Months 250 Gaelle CHALLET, Marie GRALL-BRONNEC 2020-04-27
A prospective, multicenter, randomized, placebo-controlled, double-blind, phase II clinical study to assess the efficacy, safety and tolerability of IMU-838 in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection standard-of-care antiviral therapy alone, vidofludimus alone Dihydroorotate dehydrogenase inhibitor, IL-17 antagonist Immunic Inc Europe, US Phase 2 Clinical Planned 0 2020-04-23
A multinational, randomized, controlled, investigator-initiated clinical trial in patients with confirmed COVID-19 infections Coronavirus disease 19 infection conestat alfa alone Complement C1s subcomponent inhibitor, Kallikrein modulator, Mannan-binding lectin serine protease inhibitor Pharming Group NV Switzerland Phase Not Applicable Planned 1 150 Michael Osthoff 2020-04-23
A Human Clinical Study to Collect Calibration and Performance Data for the RBA-2 Device Coronavirus disease 19 infection RBA-2, Kaligia Biosciences alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kaligia Biosciences LLC University of South Florida US 2020-04-30 2020-12-31 KBS005, NCT04357977 Phase Not Applicable Not yet recruiting 0 8 Months 300 Asa Oxner, MD, Elsie Medina, MS, Fazal Fazlin, Janice Shirley, MPH MBA PA-C, Jose Tirado, Rachel Karlnoski, PhD 2020-04-24
Etoposide in Patients With COVID-19 Infection Coronavirus disease 19 infection, Respiratory failure etoposide phosphate alone Topoisomerase II inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Boston Medical Center Corp US 2020-04-30 2021-12-31 H-40102, NCT04356690 Phase 2 Clinical Not yet recruiting 0 20 Months 134 John Mark Sloan, MD, Sally A Fennessey, BS 2020-04-24
COVID-19 Surveillance of Patients and Healthcare Workers in a Hospital Department Coronavirus disease 19 infection, Upper respiratory tract infection COVID-19 test alone, polymerase chain reaction alone Healthy volunteers accepted Rigshospitalet, Denmark Denmark 2020-03-23 2020-12-31 DT P-2020-353, NCT04356560 Phase Not Applicable Recruiting 1 9 Months 300 Inge J Knudsen, MD, Nikolai S Kirkeby, MSc, Ramon G Jensen, MD 2020-04-25
Cell therapy in patients with coronavirus19 Coronavirus disease 19 infection mesenchymal stem cells alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Barakat Pharmaceutical Group, Tehran University of Medical Sciences Iran 2020-04-20 IR.TUMS.VCR.REC.1399.203, IRCT20190717044241N2 Phase 1 Clinical Recruiting 1 10 Dr Javad Verdi- Dr Neda Alijani, Dr Mohammad Ali Sahraian, Dr Neda Alijani, Dr. Akbar Borandegi, Mahshid Saleh 2020-04-24
KONS-COVID-19: Kerecis Oral and Nasal Spray for Treating the Symptoms of COVID-19 Coronavirus disease 19 infection, Upper respiratory tract infection Kerecis Oral and Nasal Spray device (Kerecis Ehf) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kerecis Ehf Iceland 2020-04-30 2020-07-31 KONS-COVID-19, KS-0470, NCT04357990 Phase Not Applicable Not yet recruiting 1 3 Months 81 2020-04-27
TRAPSAH: Long-term Use of Drugs That Could Prevent the Risk of Serious COVID-19 Infections or Make it Worse Coronavirus disease 19 infection, Diabetes mellitus, Respiratory failure angiotensin receptor blocker (ARB) therapy alone, angiotensin-converting enzyme (ACE) therapy alone, chloroquine alone, hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris GIS EPI-PHARE France 2020-04-30 2020-06-30 APHP200412, NCT04356417, TRAPSAH Phase Not Applicable Not yet recruiting 1 2 Months 6000000 Emilie SBIDIAN, Pr, Emilie Sbidian, Pr 2020-04-26
STARS: Study of Alteplase for Respiratory Failure in SARS-Cov2 (COVID-19) Coronavirus disease 19 infection, Respiratory failure alteplase plus unfractionated heparin Tissue plasminogen activator stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Denver Health and Hospital Authority Beth Israel Deaconess Medical Center, Genentech Inc, Long Island Jewish Med Center, National Jewish Health, University of Colorado, Denver, US US 2020-04-30 2020-10-31 20-0880, NCT04357730, STARS Phase 2a Clinical Not yet recruiting 0 6 Months 60 Arsen Ghasabyan, MPH, Ernest "Gene" Moore, MD, Ernest E Moore, MD 2020-04-26
A new clinical trial to significantly increase the rate of recovery for COVID-19 patients with underlying health conditions and save lives using D'OXYVA (deoxyhemoglobin vasodilator) Coronavirus disease 19 infection D'OXYVA (deoxyhemoglobin vasodilator) alone Circularity Healthcare LLC US Phase Not Applicable Planned 0 2020-04-23
Cardiac Arrhythmias In Patients With Coronavirus Disease (COVID-19) Coronavirus disease 19 infection, Heart arrhythmia Mount Sinai School of Medicine US 2020-04-09 2021-12-31 GCO 20-0931, NCT04358029 Phase Not Applicable Recruiting 0 20 Months 10000 Betsy Ellsworth, MSN, Martin Goldman, MD, Stephanie Harcum, MS, Vivek Reddy, MD 2020-04-27
PsyCOVID: COVID-19 Pandemic Burden in Severe Mental Disease Patients Acute stress disorder, Anxiety disorder, Bipolar disorder, Coronavirus disease 19 infection, Major depressive disorder, Psychotic disorder, Schizophrenia GAD-7 (7-item Generalized Anxiety Disorder) alone, PHQ-9 (9-item Patient Health Questionnaire) alone, PSS (Perceived Stress Scale) alone, SPEQ (Specific Psychotic Experiences Questionnaire) - Paranoia and Grandiosity Subscales alone, Zaritt Burden Interview alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Universita degli Studi di Napoli Federico II Italy 2020-04-10 2020-04-25 152/20, NCT04357769, PsyCOVID Phase Not Applicable Recruiting 1 400 Felice Iasevoli, Felice Iasevoli, M.D., Ph.D. 2020-04-26
COVeR: COVID-19 Epidemic Response Study Coronavirus disease 19 infection Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centogene Gmbh Germany 2020-04-20 2020-10-30 COVER-2020, COVeR, NCT04357496 Phase Not Applicable Not yet recruiting 1 6 Months 400 Arndt Rolfs, Prof., Volha Skrahina, PhD 2020-04-26
The Mental Health Status of the General Population During the COVID-19 Pandemic and Its Association With Adherence to Government-initiated Non-pharmacological Epidemiological Interventions (NPI's) Anxiety disorder, Coronavirus disease 19 infection, Depression Non-pharmacological interventions alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oslo Modum Bad Norway 2020-03-31 2020-04-07 NCT04356365, REK125510 Phase Not Applicable Completed 1 10084 Asle Hoffart, PhD, Omid V. E Ebrahimi, Double PhD Candidate, Sverre Urnes Johnson, PhD 2020-04-27
Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection Coronavirus disease 19 infection, Respiratory failure AirGo respiratory monitor alone, non-invasive monitoring alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Massachusetts General Hospital US 2020-04-15 2020-12-31 2020P000881, NCT04356443 Phase Not Applicable Recruiting 0 8 Months 500 Jeanine Wiener-Kronish, MD, M. Brandon Westover, MD, PhD, Omar Hyder, Omar Hyder, MD, MS 2020-04-27
Prognosis of Coronavirus Disease 2019 (COVID-19) Patients Receiving Antihypertensives Cardiac failure, Coronary artery disease, Coronavirus disease 19 infection, Diabetes mellitus, Hypertension, Respiratory distress syndrome angiotensin II receptor blocker therapy alone, angiotensin-converting enzyme inhibitor therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) King Faisal Specialized Hospital & Research Center Saudi Arabia 2020-04-12 2020-09-30 2210061, NCT04357535 Phase Not Applicable Recruiting 1 5 Months 226 Abir H Omer, Hakeam A Hakeam, MS Pharm, Hakeam A Hakeam, MSPharm BCPS, Muhannad A Alsemari, MBBS 2020-05-01
SCHIZOVID-19: COVID-19 and Psychotic Symptoms in France Coronavirus disease 19 infection, Hallucination, Paranoia, Psychotic disorder survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University Hospital, Montpellier Centre référent de réhabilitation psychosociale de Grenoble, Epsylon Laboratory, Universite Grenoble Alpes France 2020-04-01 2020-08-01 NCT04356885, RECHMPL20_0225, SCHIZOVID-19 Phase Not Applicable Recruiting 1 4 Months 600 Stephane Raffard, PhD, Stéphane RAFFARD, PhD 2020-04-24
COPLA: Treatment of Severe Forms of Coronavirus Infection With Convalescent Plasma Coronavirus disease 19 infection convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centro de Hematologia y Medicina Interna Laboratorios Clinicos de Puebla, Laboratorios Ruiz Mexico 2020-04-13 2020-08-31 CHMI-030420-01, COPLA, NCT04357106 Phase 2 Clinical Recruiting 1 4 Months 10 Guillermo J Ruiz-Arguelles, MD, FRCP, MACP, DSc, Guillermo J. RUIZ-ARGÜELLES, José Manuel Priesca-Marin, MD, Juan Carlos Olivares-Gazca, MD, MPH, Juan Carlos Olivares-Gazca, MD,MPH 2020-04-27
Investigating the efficacy of Zofa (a herbal medicine) in symptom management of patients with COVID-19 Coronavirus disease 19 infection Zofa alone, routine treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Baqiyatallah University of Medical Sciences, Niak Pharmaceutical Company Iran 2020-03-30 IR.BMSU.REC.1399.027, IRCT20080901001165N48 Phase 3 Clinical Recruiting 1 100 Ali Ghazvini, Parisa Kianpour, Yunes Panahi 2020-04-29
Efficacy of convalescent plasma transfusion of COVID-19 survivors on the treatment of respiratory failure of these patients Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure, Viral pneumonia antivirals alone, convalescent plasma alone, mechanical ventilation alone, oxygen therapy alone, supportive care therapies alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tabriz University of Medical Sciences Iran 2020-05-04 IR.TBZMED.REC.1399.018, IRCT20200406046968N2 Phase 2/Phase 3 Clinical Not yet recruiting 1 30 Haleh Mikaeili 2020-04-29
A prospective, cohort study to follow the health status of medical staff engage in COVID-19 Coronavirus disease 19 infection medical staff followup alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yokohama City University Japan 2020-04-23 UMIN000040219 Phase Not Applicable Recruiting 1 30 Takuma HIGURASHI 2020-04-27
IMAGE-19: Imatinib In COVID-19 Disease In Aged Patients Coronavirus disease 19 infection imatinib alone Abl tyrosine kinase inhibitor, Bcr protein inhibitor, Kit tyrosine kinase inhibitor, PDGF receptor antagonist, Signal transduction inhibitor Aged Adults (65-79 yrs), Elderly Adults (80 and over) Versailles University Hospital France 2020-05-01 2020-12-01 IMAGE-19, NCT04357613, P20/05_IMAGE19 Phase 2 Clinical Not yet recruiting 2 7 Months 99 Laure Morisset, Malvy, Philippe Rousselot 2020-04-30
Tranilast in COVID19 Coronavirus disease 19 infection, Viral pneumonia Tranilast ( TAIYO ) alone, routine treatment alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ahvaz University of Medical Sciences Iran 2020-05-04 IR.AJUMS.REC.1399.050, IRCT20200419047128N1 Phase 3 Clinical Not yet recruiting 1 60 Ali khodadadi, َAli Khodadadi 2020-04-29
LILIADE-COVID: Low Dose of IL-2 In Acute Respiratory Distress Syndrome Related to COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome aldesleukin (subcutaneous, autoimmune/inflammatory disorders/allergy/spontaneous abortion), ILTOO Pharma alone Interleukin-2 ligand Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris ILTOO Pharma France 2020-04-30 2020-07-31 2020-001571-32, APHP200406, LILIADE-COVID, NCT04357444 Phase 2 Clinical Not yet recruiting 1 3 Months 30 Jean-Michel CONSTANTIN, Jean-Michel CONSTANTIN, MD, PhD 2020-04-24
A Phase II Study of DN-TNF to treat patients with pulmonary complications from COVID-19 infection Coronavirus disease 19 infection, Hypoxia, Lung disease, Respiratory distress syndrome anti-TNF therapy, (pulmonary complications/COVID-19), INmune Bio alone ICAM-1 stimulator, TNF antagonist, Vascular cell adhesion protein 1 agonist INmune Bio Inc Phase 2 Clinical Not yet recruiting 0 2020-04-27
AIRVM-COVID: Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to COVID-19-related Pneumonia Coronavirus disease 19 infection, Hypoxia, Respiratory failure, Viral pneumonia almitrine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Assistance Publique Hopitaux de Paris Centre Hospitalier of Chartres France 2020-04-30 2020-07-31 2020-001909-22, AIRVM-COVID, APHP200461, NCT04357457 Phase 3 Clinical Not yet recruiting 1 3 Months 212 Pierre KALFON, PU-PH, Yonathan FREUND, PU-PH, Yonathan Freund, PU-PH 2020-04-27
Clinical trial of RLS-0071 for inflammatory disorders, such as acute lung injury, caused by an inflammatory response, such as due to COVID-19 infection Coronavirus disease 19 infection, Inflammatory disease, Lung injury PIC1-01 alone Complement C1s subcomponent inhibitor ReAlta Life Sciences Inc Phase Not Applicable Planned 0 2020-04-27
TOC-COVID: A prospective, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia conventional treatment alone, tocilizumab alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Klinikum der Albert-Ludwigs Universitaet Freiburg Germany 2020-04-27 2020-001408-41, 203/20 (FF-MC), DRKS00021238, TOC-COVID Phase 2 Clinical Recruiting 2 200 Mr PD Dr Tobias Wengenmayer 2020-04-29
Biomarker COVID-19: Local and systemic markers of inflammation and circadian rhythmicity in COVID-19 disease and their role in the prediction of clinical outcome Coronavirus disease 19 infection, Respiratory failure intensive care therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Klinikum der Albert-Ludwigs Universitaet Freiburg Germany 2020-04-21 225/20, Biomarker COVID-19, DRKS00021522 Phase Not Applicable Recruiting 1 50 Nils Schallner 2020-04-30
COVID-19 BaWu: Prevalence of COVID-19 in children aged 1 to 10 years in Baden-Wurttemberg Coronavirus disease 19 infection Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs) Zentrum für Infektionskrankheiten Germany 2020-04-22 COVID-19 BaWu, DRKS00021521, S-294/2020 Phase 0 Clinical Recruiting 5 2000 Georg Friedrich Hoffmann, Hanna Renk, Hans-Georg Kräusslich, Klaus-Michael Debatin, Philipp Henneke 2020-04-24
COVID-19 Data-bank Project Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mahajan Imaging Center India 2020-04-17 CTRI/2020/04/024697 Phase Not Applicable Not yet recruiting 3 100000 Dr Anurag Agarwal, Dr Sushila Kataria, VIdur Mahajan 2020-04-27
A phase II clinical trial to evaluate the safety and efficacy of ArtemiC on patients diagnosed with COVID-19 Coronavirus disease 19 infection ArtemiC alone MGC Pharma Swiss PharmaCan AG Israel Phase 2 Clinical Not yet recruiting 1 50 2020-04-23
A clinical study on side effects of hydroxychloroquine in health care workers Coronavirus disease 19 infection hydroxychloroquine alone Indian Council of Medical Research Phase Not Applicable Status not specified 0 2020-04-24
A clinical trial to evaluate the efficacy of hydroxychloroquine as a preventive medicine for COVID-19 Coronavirus disease 19 infection hydroxychloroquine alone Indian Council of Medical Research Phase 3 Clinical Recruiting 0 480 2020-04-24
A large, multi-arm study to assess the effect of COVID-19 vaccine (protein subunit, injectable), University of Queensland in the prevention of patients with Covid-19 Coronavirus disease 19 infection protein subunit vaccine (molecular clamp, 2019-nCoV infection), University of Queensland alone University of Queensland Netherlands 2020-09-30 Phase Not Applicable Planned 1 2020-04-30
Use of UC-MSCs for COVID-19 Patients Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome standard of care alone, umbilical cord-derived mesenchymal stem cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Miami US 2020-04-25 2021-05-01 20200370, NCT04355728 Phase 1/Phase 2 Clinical Recruiting 0 12 Months 24 Camillo Ricordi, MD, David A Baidal, M.D., Khemraj Hirani, MPharm PhD RPH, Rodolfo Alejandro, M.D. 2020-04-29
Gut Microbiota, 'Spark and Flame' of COVID-19 Disease Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidade Nova De Lisboa CINTESIS - Centre for Health Technology and Services Research, CUF Academic and Research Medical Center, Centro Hospitalar Lisboa Ocidental, Centro Hospitalar Sao Joao, Centro de Medicina Laboratorial Germano de Sousa, S.A., Hospital CUF Infante Santo, S.A., Nova Medical School Portugal 2020-04-30 2020-12-31 COVID19_MICROBIOTA, NCT04355741 Phase Not Applicable Not yet recruiting 3 8 Months 60 André Rosário, PhD, Conceição Calhau, PhD, Cristina Granja, PhD, Gonçalo Marcelino, José Leal, PhD, Maria JR Sousa, PhD, Pedro Póvoa, PhD 2020-04-24
Convalescent Plasma versus Placebo in Emergency Room Patients With COVID-19 Coronavirus disease 19 infection convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stanford University US 2020-05-31 2022-12-31 56249, NCT04355767 Phase 2 Clinical Not yet recruiting 0 31 Months 206 Kevin Schulman, MD, Study Team 2020-04-23
TARUS: The Ariel University Survey on Dietary Changes and Anxiety During the Coronavirus Pandemic Anxiety disorder, Coronavirus disease 19 infection survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ariel University Israel 2020-03-31 2020-05-31 AU-HEA-VKS-20200329, NCT04353934, TARUS Phase Not Applicable Recruiting 1 2 Months 3000 Mona Boaz, RD, PhD, Vered Kaufman-Shriqui, RD, PhD 2020-04-23
URGDENTCOVID: Evaluation of Dental Emergency Treatments During COVID19 Crisis Coronavirus disease 19 infection, Tooth disease survey alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris 2020-04-13 2020-06-20 APHP200464, NCT04354272, URGDENTCOVID Phase Not Applicable Not yet recruiting 0 2 Months 840 Isabelle Rodriguez, Yves Boucher, MD, PhD 2020-04-23
ENVIROREA: Dissemination of SARS-COV-2 (COVID-19) in the Environment of Infected Patients Admitted to Intensive Care Unit Coronavirus disease 19 infection, Lower respiratory tract infection Coriolis system alone, RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-04-17 2020-12-17 2020-A00897-32, APHP200411, ENVIROREA, NCT04355481 Phase Not Applicable Recruiting 3 8 Months 150 Guillaume Voiriot, Dr, Lila Bouadma, Dr, Nacira DARGHAL, Yacine TANDJAOUI-LAMBIOTTE, Dr 2020-04-30
An investigator-initiated clinical trial of valsartan in patients with COVID-19 infection Coronavirus disease 19 infection valsartan alone Angiotensin I receptor antagonist, Angiotensin II receptor antagonist Novartis AG Phase Not Applicable Planned 0 2020-04-22
AVISA: Assessment of Incidence of SARS-CoV-2 Infection and COVID-19 in Brazil Coronavirus disease 19 infection IgG/IgM SARS-CoV-2 rapid test alone, blood sampling alone Healthy volunteers accepted Instituto Butantan Brazil 2020-05-15 2022-05-15 AVISA, COV-01-IB, NCT04355338 Phase Not Applicable Not yet recruiting 1 24 Months 4100 Ricardo Palacios, MD, PhD 2020-04-29
An investigator-initiated clinical study of secukinumab for the treatment in patients with COVID-19 infection Coronavirus disease 19 infection secukinumab alone IL-17 antagonist Novartis AG Phase Not Applicable Planned 0 2020-04-22
An investigator-initiated clinical study of imatinib mesylate for the treatment in patients hospitalized with COVID-19 Coronavirus disease 19 infection imatinib alone Abl tyrosine kinase inhibitor, Bcr protein inhibitor, Kit tyrosine kinase inhibitor, PDGF receptor antagonist, Signal transduction inhibitor Novartis AG Phase Not Applicable Planned 0 2020-04-22
A clinical study of canakinumab for the treatment in patients hospitalized with COVID-19 infection Coronavirus disease 19 infection canakinumab alone Immunoglobulin G1 agonist, Interleukin-1 beta ligand inhibitor Novartis AG Phase Not Applicable Planned 0 2020-04-22
Expanded Access Program of Ruxolitinib for the Emergency Treatment of Cytokine Storm From COVID-19 Infection Coronavirus disease 19 infection, Respiratory distress syndrome ruxolitinib (oral, myeloproliferative disorders), Incyte/Novartis alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Incyte Corp US INCB 18424-MA-COVID-19-301, NCT04355793 Phase Not Applicable Recruiting 0 Incyte Corporation Call Center (US) 2020-04-25
CORIA: Coronavirus (COVID-19) Outcomes Registries in Immunocompromised Individuals Australia Cancer, Coronavirus disease 19 infection, HIV infection, Immune deficiency blood sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Centre in HIV Epidemiology and Clinical Research Blacktown Hospital, Cancer Council New South Wales, Cancer Institute New South Wales, Garvan Institute of Medical Research, Gilead Sciences Inc, Holdsworth House Medical Practice, Melanoma Institute Australia, Positive Life NSW, Prince of Wales Hospital foundation, Royal North Shore Hospital, St Vincents Hospital Sydney Ltd, Westmead Hospital Australia 2020-04-27 2022-04-27 2020-04-CORIA, CORIA, NCT04354818 Phase Not Applicable Not yet recruiting 1 24 Months 1000 Griselda Buckland, Mark Polizzotto, MD 2020-04-23
COSTA: Open-label Study to Compare Efficacy, Safety and Tolerability of Hydroxychloroquine Combined With Azithromycin Compared to Hydroxychloroquine Combined With Camostat Mesylate and to 'no Treatment' in SARS CoV 2 Virus Coronavirus disease 19 infection, Viral pneumonia camostat mesylate plus hydroxychloroquine Serine protease inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sheba Medical Center Israel 2020-04-11 2020-12-11 7092-20-SMC, COSTA, NCT04355052 Phase 3 Clinical Recruiting 1 8 Months 250 Irit Avisar, RN, Itsik Levy Dr, Itzchak Levy, MD 2020-04-22
A randomized, double-blind, placebo-controlled Phase IIa study to evaluate the safety and efficacy of opaganib in adult patients hospitalized with positive SARS-CoV-2 and pneumonia Coronavirus disease 19 infection, Viral pneumonia opaganib alone Dihydroceramide delta 4 desaturase inhibitor, Sphingosine kinase 2 inhibitor RedHill Biopharma Ltd US Phase 2a Clinical Planned 0 60 2020-04-29
A Study Evaluating the Efficacy and Safety of High-Titer Anti-SARS-CoV-2 Plasma in Hospitalized Patients With COVID-19 Infection Coronavirus disease 19 infection, SARS coronavirus infection anti-SARS-CoV-2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical College of Wisconsin Froedtert Hospital US 2020-05-01 2023-05-01 NCT04354831, PRO00037712 Phase 2 Clinical Not yet recruiting 0 36 Months 131 Mary Beth Graham, Mary Beth Graham, MD, Sonija Parker 2020-04-29
Soliris (Eculizumab) Treatment of Participants With COVID-19 Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia eculizumab alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Alexion Pharmaceuticals Inc France ECU-COV-401, NCT04355494 Phase Not Applicable Recruiting 5 Alexion Pharmaceuticals Inc. 2020-04-26