Last updated: May 12, 2020 - 02:00 BST

Title Indication Intervention Actions PatientSelection Sponsor Collaborator Country StartDate EndDate Identifiers Phase Recruitment Status Sites Trial Duration Enrollment Count Contacts LastChanged
Low-Dose Anti-inflammatory Radiotherapy for the Treatment of Pneumonia by COVID-19 Coronavirus disease 19 infection, Viral pneumonia low-dose radiotherapy (0.5 Gy) alone, Variable regimens including Dolquine , azithromycin , dexamethasone , heparin , lopinavir + ritonavir , methylprednisolone , oxygen , prednisone , tocilizumab (intravenous), Roche/Chugai HIV protease inhibitor, IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Grupo de Investigación Clínica en Oncología Radioterapia Hospital Universitari Sant Joan de Reus, Hospital Universitario Madrid Sanchinarro, Hospital del Mar Spain 2020-05-08 2021-07-01 IPACOVID, NCT04380818 Phase 2 Clinical Recruiting 0 13 Months 106 ANGEL MONTERO, Md, PhD, Angel Montero, MD, PhD, MANEL ALGARA, MD, PhD, MERITXELL ARENAS, MD, PhD, Manel Algara, MD, PhD, Merirxell Arenas, MD, PhD 2020-05-11
Prevalence of Severe Bleeding in COVID-19 Patients Treated With Higher Than Recommended Thromboprophylaxis Doses Bleeding, Coronavirus disease 19 infection thromboprophylaxis therapy alone Foundation for the study of VTE diseases (FUENTE) Spain 2020-04-13 2025-06-13 BLEEDING042020, NCT04380779 Phase Not Applicable Recruiting 0 62 Months 5000 Manuel Monreal, Mayra Hawkins 2020-05-11
A Pilot Study Evaluating the Effect of NT-17, a Long Acting Interleukin-7, to Enhance Immune Clearance of SARS-CoV-2 Coronavirus disease 19 infection HyLeukin-7 alone, supportive care alone IL-7 receptor agonist, Interleukin-7 ligand Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US US 2020-07-31 2021-02-28 04-20-20-CAMPIAN, NCT04380948 Phase 1 Clinical Not yet recruiting 0 7 Months 30 Erik R Dubberke, M.D., MSPH, Jian Campian, M.D., Ph.D., Jingqin (Rosy) Luo, Ph.D. 2020-05-11
A 6-week, controlled, two-arm randomized study of molecular iodine for protecting healthcare workers from COVID-19 exposure Coronavirus disease 19 infection CDC guidelines alone, ioCleanse Hand Cleanser alone, ioMist Nasal Spray alone, ioRinse Oral Rinse alone Iotech International Llc US Phase Not Applicable Recruiting 0 300 Dr. Hillel Ephros 2020-05-11
Efficacy and Safety of Polyoxidonium in Hospitalized Patients With Coronavirus Disease COVID-19 Coronavirus disease 19 infection Polyoxidonium alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) NPO Petrovax Pharm LLC Russian Federation 2020-04-29 2021-04-30 NCT04381377, PО-COV-III-20 Phase 2/Phase 3 Clinical Recruiting 0 12 Months 394 A. A. Grebenyuk, A. A. Ploskireva, A. S. Pankov, D. A. Lioznov, D. N. Protsenko, E. G. Tikhomolova, I. G. Gordeev, I. G. Sitnikov, Jean-Francois Rossi, Professor, L. V. Kolobukhina, M. V. Smirnov, Nikolay Dodonov, S. K. Zyryanov, V. V. Kulabukhov 2020-05-11
HALT COVID-19: Inhalation of Ciclesonide for Patients With COVID-19: A Randomized, Open Treatment Study Coronavirus disease 19 infection ciclesonide (metered dose inhaler), Teijin/Covis/AstraZeneca alone Glucocorticoid receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Capio Saint Göran's Hospital Danderyd Hospital, Karolinska University Hospital, Vasteras Central Hospital Sweden 2020-05-15 2020-12-31 2020-02183, HALT COVID-19, NCT04381364 Phase 2 Clinical Not yet recruiting 0 7 Months 446 Anders Krifors, MD, Daniel Brodin, MD, Daniel P Andersson, MD, PhD, Magnus Bager, MD, Ola Blennow, MD, PhD 2020-05-11
Emergency Ventilator Splitting Between Two or More Patients (COVID-19) Coronavirus disease 19 infection emergency ventilator splitter alone, oxygen therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stanford University US 2020-05-31 2020-06-30 55989, NCT04381013 Phase Not Applicable Not yet recruiting 0 1 Month 4 Joseph Woo, MD 2020-05-11
STATCO19: Atorvastatin in COVID-19 Coronavirus disease 19 infection atorvastatin alone HMG CoA reductase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mount Auburn Hospital 2020-05-08 2022-05-08 MOUNTAUBURN, NCT04380402, STATCO19 Phase 2 Clinical Not yet recruiting 0 24 Months 300 2020-05-11
Asymptomatic novel coronavirus pneumonia (COVID-19) patients Have Longer Treatment Cycle Than Mild and Moderate Patients: a medical records based study Coronavirus disease 19 infection, Viral pneumonia Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The Science and Technology Department of Guizhou Province China 2020-01-29 2020-03-31 ChiCTR2000032770 Phase 0 Clinical Completed 1 2 Months 52 Wei Zhang 2020-05-11
Co-Stars: COVID-19 Staff Testing of Antibody Responses Study Coronavirus disease 19 infection serological testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Great Ormond Street Hospital for Children NHS Foundation Trust UK 2020-04-27 2026-07-27 20CB17, Co-Stars, NCT04380896 Phase Not Applicable Recruiting 0 75 Months 1000 Louis Grandjean, Dr, Vanshree Patel, Dr 2020-05-11
Correlation between novel coronavirus pneumonia (COVID-19) and mental health of breast cancer patients: a cross-sectional study in Hunan Province Coronavirus disease 19 infection, Psychiatric disorder Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Xiangya Hospital Of Central South University Hunan Provincial Natural Science Foundation China 2020-01-01 ChiCTR2000032768 Phase Not Applicable Completed 1 309 Ling Wang 2020-05-11
Clinical efficacy of Nafamostat for COVID-19 pneumonia Coronavirus disease 19 infection, SARS coronavirus infection Nafamostat alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gyeongsang National University Hospital Ministry of Science and ICT South Korea 2020-05-25 GNUH-2020-04-012, KCT0005003 Phase 2 Clinical Not yet recruiting 7 84 In-Gyu Bae 2020-05-11
Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia convalescent plasma alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Indonesia Dr Cipto Mangunkusumo General Hospital, Faculty of Medicine, University of Indonesia Indonesia 2020-05-11 2020-08-31 CONVALESCENT PLASMA RSCM-FKUI, NCT04380935 Phase 2/Phase 3 Clinical Not yet recruiting 3 3 Months 60 Andri MT Lubis, MD, PhD, Andri Maruli Tua Lubis, Cosphiadi Irawan, MD, PhD, Elida Marpaung, MD, MBiomed, Lugyanti Sukrisman, MD, PhD, Robert Sinto, MD, Siti Rizny F Saldi, Pharm, MSc, William Djauhari, MD 2020-05-11
Evaluation of BCG as potential therapy for COVID-19 Coronavirus disease 19 infection BCG alone Young Adults (18-44 yrs) Haffkine Biopharmaceutical Corporation Ltd., Medical Education and Drugs Department India 2020-05-06 BIO/CT/20/000049, CTRI/2020/05/025013 Phase 2 Clinical Not yet recruiting 1 60 Dr Rajesh Deshmukh, Dr Sanjay Mukherjee, Dr Sonali Salvi, Dr Usha Padmanabhan 2020-05-11
Evaluation of the effect of jujube product on Covid-19 patients Coronavirus disease 19 infection jujube alone, routine protocol alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Semnan University of Medical Sciences Iran 2020-05-09 IR.SEMUMS.REC.1399.032, IRCT20171213037866N2 Phase 3 Clinical Recruiting 1 68 Ali Gohari, Nasim Behnoud, Parviz Kokhaie 2020-05-11
The effectiveness of educational-treatment package based on psychological flexibility in burnout, quality of working life, work-family conflict and mental health Coronavirus disease 19 infection training package alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Isfahan University of medical Sciences Iran 2020-05-04 IR.MUI.MED.REC.1399.026, IRCT20200413047052N1 Phase Not Applicable Recruiting 1 60 Amrolla Ebrahimi, Amrullah Ebrahimi, Sayed Mohammad Hosein Mosavi 2020-05-11
A phase III study of EDP-1815 for the treatment of COVID-19 infection Coronavirus disease 19 infection EDP-1815 alone Evelo Biosciences Inc Phase 3 Clinical Planned 0 2020-05-11
MiRCOVID: Noncoding RNAs in COVID-19 and COVID-19 Related Kidney Dysfunction Coronavirus disease 19 infection, Renal injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Heinrich Heine Universitat Dusseldorf Germany 2020-04-16 2021-07-31 1, MiRCOVID, NCT04381351 Phase Not Applicable Recruiting 1 15 Months 50 Dr. Timo Brandenburger, Timo Brandenburger, MD 2020-05-11
Predi-COVID: Luxembourg Cohort of Positive Patients for COVID-19: a Stratification Study to Predict Patient Prognosis Coronavirus disease 19 infection biological sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Luxembourg Institute of Health Centre Hospitalier de Luxembourg, Hopitaux Robert Schuman (Luxembourg), Laboratoire National de santé, Universite of Luxembourg Luxembourg 2020-05-04 2021-12-31 NCT04380987, PREDI-COVID, Predi-COVID Phase Not Applicable Recruiting 0 19 Months 200 Aurelie Fischer, MS, Laetitia Huiart, MD, PhD, Manon Gantenbein, PhD 2020-05-11
Changes in the Consumption of Psychoactive Substances During Containment Linked to COVID-19 Coronavirus disease 19 infection psychoactive substances alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-05-01 2020-08-01 NCT04380714, RECHMPL20-0273 Phase Not Applicable Recruiting 1 3 Months 700 Aurélie Mieuset, MD, Aurélie Mieuset, PhD 2020-05-11
Oral Health and Psychosocial Factors During the COVID-19 Pandemic Coronavirus disease 19 infection, Periodontitis, Psychiatric disorder Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Heidelberg Germany 2020-05-08 2020-07-31 NCT04381273, S-303/2020 Phase Not Applicable Recruiting 1 2 Months 1000 Antonio Ciardo, Dr. 2020-05-11
Tableted COVID-19 Therapeutic Vaccine (COVID-19) Coronavirus disease 19 infection V-SARS alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Immunitor LLC Immunitor Inc Canada 2020-06-15 2021-06-15 IMM24, NCT04380532 Phase 1/Phase 2 Clinical Recruiting 1 12 Months 20 Aldar Bourinbaiar, MD/PhD, Allen Bain, PhD 2020-05-11
COVIDADOMEVA: Risk Factors Worsening COVID-19 for Out-patient With Home Monitoring Coronavirus disease 19 infection University Hospital, Grenoble France 2020-05-15 2020-12-30 2020-A01040-39, 38RC20.135, COVIDADOMEVA, NCT04380662 Phase Not Applicable Not yet recruiting 1 7 Months 1000 Guillaume DEBATY, PhD, Olivier EPAULARD, PhD, Sandra DAVID-TCHOUDA, MD, Sandrine MASSICOT, Master 2020-05-11
COVID-OLD: Direct and Indirect Impact of COVID-19 In Older Populations Coronavirus disease 19 infection Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Grenoble France 2020-04-09 2021-10-09 2020-A00846-33, 38RC20.118, COVID-OLD, NCT04381312 Phase Not Applicable Recruiting 1 18 Months 1000 Gaetan GAVAZZI, Pr, Gaëtan Gavazzi, PhD Professor, Saber Touati, ARC 2020-05-11
A randomized, double-blind, placebo-controlled clinical trial to assess whether hydroxychloroquine and azithromycin reduce hospitalization and/or death in individuals suffering from COVID-19 Coronavirus disease 19 infection azithromycin plus hydroxychloroquine National Institutes of Health Phase Not Applicable Not yet recruiting 0 2000 Eric Daar 2020-05-11
A clinical trial of CERC-002 for potential treatment of Acute Respiratory Distress Syndrome (“ARDS”) and Acute Lung Injury (“ALI”) in hospitalized COVID-19 patients Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome CERC-002 alone Tumor necrosis factor 14 ligand inhibitor Cerecor Inc Phase Not Applicable Recruiting 0 2020-05-11
COVID-19 HOPE Study: A clinical study to assess AT-H201 in the treatment of subjects with COVID-19 infection Coronavirus disease 19 infection AT-H201 alone Atossa Genetics Inc US COVID-19 HOPE Study Phase Not Applicable Not yet recruiting 0 2020-05-11
A Study to Evaluate the Efficacy and Safety of Sirukumab in Confirmed Severe or Critical Confirmed Coronavirus Disease (COVID)-19 Coronavirus disease 19 infection sirukumab alone, standard of care (SOC) alone IL-6 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Janssen Pharmaceutica NV US 2020-04-24 2020-09-16 CNTO136COV2001, CR108820, NCT04380961 Phase 2 Clinical Recruiting 0 4 Months 270 Study Contact 2020-05-11
SCREENING: Prevalence of DVT or PE in Patients Infected With COVID-19 Admitted to Hospital Coronavirus disease 19 infection, Deep vein thrombosis, Lung embolism ultrasonography alone Foundation for the study of VTE diseases (FUENTE) Spain 2020-04-13 2025-06-30 NCT04380792, SCREENING, SCREENING042020 Phase Not Applicable Recruiting 1 62 Months 5000 Manuel Monreal, Mayra Hawkins 2020-05-11
MEND: An open-label, randomized controlled clinical trial to investigate early efficacy of Cymerus mesenchymal stem cells (MSCs) in adults admitted to intensive care with COVID-19 and respiratory distress Coronavirus disease 19 infection, Respiratory distress syndrome mesenchymoangioblast-derived mesenchymal stem cell therapy (Cymerus, critical limb ischemia/graft versus host disease/asthma/diabetic foot ulcer), Cynata/FUJIFILM alone, standard of care alone Cynata Therapeutics Ltd Cerebral Palsy Alliance Research Foundation Australia MEND Phase Not Applicable Not yet recruiting 1 24 2020-05-11
Clinical trial on the treatment of novel coronavirus pneumonia (COVID-19) patients suspected with gut microbiota dysbiosis with washed microbiota transplantation Coronavirus disease 19 infection Routine treatment alone, Washed microbiota transplantation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Guangzhou 8th People's Hospital China 2020-05-08 2021-06-08 2020KZDZX1132, ChiCTR2000032737 Phase 0 Clinical Not yet recruiting 2 13 Months 60 Li-Hao Wu, Zhi-Ning Ye 2020-05-11
Clinical trial evaluating two ventilator settings in Corona virus related severe lung diseases ( known as ARDS) Coronavirus disease 19 infection, Respiratory distress syndrome Lowest driving pressure guided PEEP alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences India 2020-05-16 CTRI/2020/05/025071 Phase 3 Clinical Not yet recruiting 1 40 Dr Ajisha Aravindan 2020-05-11
TRANSPULMONARY-COVID19: Transpulmonary Driving Pressure in ARDS COVID-19 Patients Coronavirus disease 19 infection, Respiratory distress syndrome Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2019-04-01 2021-12-31 NCT04381286, RECHMPL20_0194, TRANSPULMONARY-COVID19 Phase Not Applicable Recruiting 1 33 Months 40 Ramin SEVERIN, MD, Ramin Séverin, MD 2020-05-11
Had COVID-19 Spread in Nagasaki Prefecture before the first confirmed case? Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nagasaki University Japan 2020-06-01 UMIN000040278 Phase Not Applicable Not yet recruiting 1 182 Katsunori Yanagihara, Norihito Kaku 2020-05-11
COVID-19/Qing Fei Pai Du Tang Coronavirus disease 19 infection Qing Fei Pai Du Tang alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Tokyo Takanawa Hospital Japan 2020-05-09 UMIN000040341 Phase Not Applicable Not yet recruiting 1 15 Tomoka Ebisui, Tsutomu Nakamura 2020-05-11
Study on risk perception and behavioral change related to COVID-19 Coronavirus disease 19 infection educational counseling alone, training alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University of Tokyo Ministry of Education, Culture, Sports, Science and Technology of Japan Japan 2020-05-12 UMIN000040286 Phase Not Applicable Not yet recruiting 1 1980 Tsuyoshi Okuhara 2020-05-11
Impacts of COVID-19 on frailty in community-dwelling older adults; a cross-sectional study Coronavirus disease 19 infection Aged Adults (65-79 yrs), Elderly Adults (80 and over) Takasaki University of Health and Welfare Japan 2020-05-08 UMIN000040335 Phase Not Applicable Not yet recruiting 1 346 Tomoyuki Shinohara 2020-05-11
CALAVI US: Acalabrutinib Study With Best Supportive Care Versus Best Supportive Care in Subjects Hospitalized With COVID-19 Coronavirus disease 19 infection, Viral pneumonia acalabrutinib alone, best supportive care alone Btk tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AstraZeneca Pharmaceuticals LP Acerta Pharma BV US 2020-05-12 2020-09-30 CALAVI US, D822FC00003, NCT04380688 Phase 2 Clinical Not yet recruiting 0 4 Months 60 AstraZeneca Clinical Study Information Center 2020-05-11
KomCo: Communication in times of the corona virus pandemic (COVID-19) Coronavirus disease 19 infection Universitätsmedizin Rostock Germany 2020-04-02 A 2020-0068, DRKS00021676, KomCo Phase Not Applicable Recruiting 1 200 Christian Junghanß 2020-05-11
An international clinical trial of oral macrophage activating factor in the prevention of the COVID-19 associated cytokine storm Coronavirus disease 19 infection macrophage activating factor alone Saisei Pharma Co Ltd Phase Not Applicable Planned 0 2020-05-11
A double-blind clinical study to evaluate the efficacy of the Manremyc food supplement for those health professionals who are most exposed to the risk of contracting COVID-19 Coronavirus disease 19 infection Manremyc alone Reig Jofre Group IDIAP jordi gol, Institut Germans Trias I Pujol (Igtp) Spain 2020-05-31 Phase Not Applicable Recruiting 1 300 Dr. Pere-Joan Cardona 2020-05-11
Effect of propolis in COVID-19 Coronavirus disease 19 infection propolis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Abadan University of Medical Sciences Iran 2020-05-21 IR.ABADANUMS.REC.1399.031, IRCT20200326046868N1 Phase 3 Clinical Not yet recruiting 1 88 Reza Malihi, Sara Mobarak 2020-05-11
The effect of herbal syrup on patients with Corona Coronavirus disease 19 infection herbal thyme syrup intake alone, azithromycin plus lopinavir + ritonavir HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Mazandaran University of Medical Sciences Iran 2020-04-04 IR.MAZUMS.REC.1398.1456, IRCT20131129015584N2 Phase 3 Clinical Recruiting 1 152 Assie Jokar, Dr Assie Jokar, Dr Majid Saidi 2020-05-11
The Effect of Convalescent Plasma Therapy on Patients with 19-COVID Coronavirus disease 19 infection convalescent plasma therapy alone, routine treatment alone Ardabil University of Medical Sciences Iran 2020-05-12 IR.ARUMS.REC.1399.052, IRCT20150808023559N21 Phase 1/Phase 2 Clinical Not yet recruiting 1 60 Effat Irani Jam, Shahab Bohlooli, Somaieh Matin 2020-05-11
Effect of interferon-beta1 (Zifron) on clinical improvement and prognosis of COVID-19 in Tabriz Imam-Reza hospital Coronavirus disease 19 infection, Respiratory failure Variable regimens including hydroxychloroquine , interferon-beta1, Zifron Zist Darou Danesh , lopinavir + ritonavir HIV protease inhibitor Zist Daru Danesh Company Iran 2020-04-29 IR.TBZMED.REC.1399.019, IRCT20200406046968N3 Phase 2 Clinical Recruiting 0 60 Hooshmand Ilka, Mikaeili Haleh 2020-05-11
RAVEN: Ruxolitinib therapy to Avoid Ventilation and improve outcome for deteriorating COVID-19 patients Coronavirus disease 19 infection ruxolitinib (oral, myeloproliferative disorders), Incyte/Novartis alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Guy's & St Thomas' Hospital NHS Trust Novartis Pharmaceuticals UK Ltd UK 2020-05-06 2020-001777-71, RAVEN, RAVEN Phase 4 Clinical No longer recruiting 1 59 Donal McLornan 2020-05-11
A study of subclinical infection of COVID-19 in Kanagawa prefecture Coronavirus disease 19 infection Test for COVID-19 alone Kanagawa Physicians Association Japan 2020-05-20 UMIN000040333 Phase Not Applicable Not yet recruiting 1 1000 Ikuro Matsuba 2020-05-11
A clinical trial of DARPin for the potential treatment of COVID-19 caused by SARS-CoV-2 Coronavirus disease 19 infection DARPin (COVID-19), Molecular Partners alone Angiotensin converting enzyme 2 inhibitor Molecular Partners AG 2020-12-31 Phase Not Applicable Planned 0 2020-05-11
A phase IIb/III multinational clinical trial of NP-120 (ifenprodil (injectable/intravenous, COVID-19/acute lung injury), Nash Pharmaceuticals) for the treatment in COVID-19 diagnosed patients Coronavirus disease 19 infection ifenprodil (injectable/intravenous, COVID-19/acute lung injury), Nash Pharmaceuticals alone, standard of care (SOC) alone NMDA receptor epsilon 2 subunit inhibitor Algernon Pharmaceuticals Canada, South Korea Phase 2/Phase 3 Clinical Not yet recruiting 2 100 2020-05-11
A phase IIb/III multinational clinical trial of NP-120 (ifenprodil (long-acting, oral, COVID-19/acute lung injury), Nash Pharmaceuticals) for the treatment in COVID-19 diagnosed patients Coronavirus disease 19 infection ifenprodil (long-acting, oral, COVID-19/acute lung injury), Nash Pharmaceuticals alone, standard of care (SOC) alone NMDA receptor epsilon 2 subunit inhibitor Algernon Pharmaceuticals South Korea, Canada Phase 2/Phase 3 Clinical Not yet recruiting 2 100 2020-05-11
Investigating a vaccine against COVID-19 Coronavirus disease 19 infection ChAdOx1 nCoV-19 alone, Nimenrix alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oxford Coalition for Epidemic Preparedness Innovations, United Kingdom Research & Innovation UK 2020-03-02 2021-06-30 2020-001228-32, COV002, CPMS 45551, IRAS 281904, ISRCTN90906759 Phase 2/Phase 3 Clinical Not yet recruiting 7 15 Months 5260 Mrs Plested 2020-05-08
An Expanded Access program of use of Convalescent Plasma for Severe COVID-19 Coronavirus disease 19 infection convalescent plasma alone OneBlood, University of Miami Health System Phase Not Applicable Status not specified 0 Shweta Anjan 2020-05-08
A phase I clinical trial of live attenuated SARS-CoV-2 virus vaccine for the prevention of SARS-CoV-2 COVID-19 infection Coronavirus disease 19 infection SARS-CoV-2 vaccine (recombinant measles virus vector, COVID-19), German Center for Infection Research alone COVID19 Spike glycoprotein modulator, COVID19 nucleoprotein modulator German Center for Infection Research (DZIF) Phase 1 Clinical Planned 0 2020-05-11
Study for the application of novel coronavirus pneumonia (COVID-19) intestinal tract toxicity in diagnosis and its prognostic effect Coronavirus disease 19 infection, Viral pneumonia probiotic plus rifaximin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Union Hospital Tongji Medical School Huazhong University Of Science & Technology China 2020-05-04 2021-12-31 ChiCTR2000032686 Phase Not Applicable Not yet recruiting 1 19 Months 390 Xiaohua Hou, Yu Jin 2020-05-11
Follow-up study of pregnancy outcomes of novel coronavirus pneumonia (COVID-19) complicated in the first and second trimester Coronavirus disease 19 infection Female, Young Adults (18-44 yrs) Union Hospital Tongji Medical School Huazhong University Of Science & Technology China 2020-04-01 2020-12-31 ChiCTR2000032666 Phase Not Applicable Recruiting 1 9 Months 6 Zhao Yin 2020-05-11
A phase I clinical trial to assess the tolerability and immune response of recombinant MVA vector vaccine fo the prevention of SARS-CoV-2 COVID-19 infection Coronavirus disease 19 infection recombinant MVA vector vaccine (COVID-19), German Center for Infection Research alone COVID19 Spike glycoprotein modulator German Center for Infection Research (DZIF) Phase 1 Clinical Planned 0 2020-05-08
A clinical trial of SARS-CoV-2 therapy for the prevention/treatment of COVID-19 infection Coronavirus disease 19 infection SARS-CoV-2 therapy (COVID-19), Shionogi/Hokkaido University Research Center alone Hokkaido University, Shionogi & Co Ltd Phase Not Applicable Planned 0 2020-05-08
Study for efficacy and safety of Jie-Xing-Jun-Zi granules in the Treatment of convalescent patients of novel coronavious pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Jiexingjunzi granules alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) The Third affiliated Hospital of Beijing Traditional Chinese Medicine University China 2020-05-01 2020-12-31 ChiCTR2000032313, ChiMCTR2000003243 Phase 0 Clinical Not yet recruiting 3 8 Months 60 Hongsheng Cui, Xinxin Qin 2020-05-11
A medical records based study for optimization and evaluation of the comprehensive diagnosis and treatment of novel coronavirus pneumonia (COVID-19) and the assessment of risk factors for severe pneumonia Coronavirus disease 19 infection, Viral pneumonia The First Affiliated Hospital of Nanchang University China 2020-01-31 2020-07-31 ChiCTR2000030095 Phase 0 Clinical Recruiting 1 6 Months 94 Anjun Chen, Wei Zhang 2020-05-11
Study for Screening of Chinese Patent Drugs in the Rehabilitation Treatment of Novel Coronavirus Pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Pien Tze Huang capsule plus thymosin enteric capsule Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hubei province hospital of Traditional Chinese Medicine Ministry of Science and Technology of the People´s Republic of China China 2020-04-01 2021-03-31 ChiCTR2000032635, ChiMCTR2000003279 Phase 0 Clinical Not yet recruiting 1 12 Months 60 He Shaobin, Zhuo Yana 2020-05-11
Moxibustion Plus Cupping in Convalescent Patients With COVID-19 Coronavirus disease 19 infection Moxibustion plus Cupping alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Guang'Anmen Hospital China Academy of Chinese Medical Sciences Ezhou Hospital of traditional Chinese Medicine in Hubei Province, Huangshi Hospital of Traditional Chinese Medicine, Hubei Hospital of Integrated Traditional Chinese and Western Medicine Zhongshan Branch, Hubei province hospital of Traditional Chinese Medicine, Shenzhen Baoan Hospital of Tradition Chinese Medicine, The Affiliated Hospital of JiangXi University of TCM, China, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Wuhan Hospital of Traditional Chinese Medicine, Wuhan third Hospital China 2020-05-31 2021-12-31 2020YFC0845000, NCT04374084 Phase Not Applicable Not yet recruiting 1 19 Months 60 Jiani Wu, Xiaopin Wang, Zhongyu Zhou 2020-05-11
SurgiCovid: Surgical Activity During the Covid-19 Pandemic: Results for 112 Patients in a French Tertiary Care Center Coronavirus disease 19 infection Computed tomography chest alone, Reverse transcription polymerase chain reaction test alone, Screening test for covid alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2020-03-19 2020-04-25 CRC_GHN_2020_001, NCT04379232, SurgiCovid Phase Not Applicable Completed 1 1 Month 112 2020-05-08
FUTURE-T: Clinical Effect of Dialyzable Leukocyte Extract in Suspected or Confirmed Cases of COVID-19 Coronavirus disease 19 infection Dialyzable Leukocyte Extract alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Politecnico Nacional Mexico 2020-05-31 2020-12-31 FUTURE-T, IC-20-001, NCT04379479, SH-001-2020 Phase 2 Clinical Not yet recruiting 1 7 Months 562 Maria C Jimenez-Martínez, MD PhD, Maricarmen Sánchez-Leon, MD, Maricarmen Sánchez-León, MD, Melissa I Espinosa-Navarro, MD, Sonia Mayra Pérez-Tapia, PhD, Toni A Homberg von Thaden, MD, Toni A Homberg, MD 2020-05-11
Social Media and Covid19 Pandemic Coronavirus disease 19 infection survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Acibadem University Turkey 2020-05-01 2020-05-08 ACIBADEMU SOCIAL MEDIA, NCT04378738 Phase Not Applicable Recruiting 2 212 2020-05-08
A clinical trial to investigate and define the molecular mechanisms of SARS-CoV-2 infection and COVID-19 and identify targets for medicines and vaccines Coronavirus disease 19 infection Institute For Systems Biology, Merck & Co Inc 10X Technologies Inc, Adaptive Biotechnologies Corp, Andy Hill CARE Fund, Biomedical Advanced Research and Development Authority (BARDA), Bloodworks Northwest, Isoplexis Corp, M.J. Murdock Charitable Trust, Metabolon Inc, NanoString Technologies Inc, Parker Institute for Cancer Immunotherapy, Scisco Genetics Inc, Stanford University, Swedish Hospital, Wilkes University Phase Not Applicable Status not specified 0 200 Dr. Jason D. Goldman 2020-05-08
Efficacy of Liu-zi-jue in patients with 2019 novel Coronavirus pneumonia (COVID-19): a randomized, controlled trial Coronavirus disease 19 infection, Viral pneumonia Liu-zi-jue alone, conventional treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine China 2020-02-19 2020-07-31 ChiCTR2000032367, ChiMCTR2000003246 Phase Not Applicable Recruiting 2 5 Months 186 Min Fang, Shuaigpan Zhang 2020-05-08
Lingnan Fire-Needle Therapy Improves the Quality of Life in General Population Under the Pandemic of Novel Coronavirus Pneumonia (COVID-19): A Prospective, Randomized Controlled Trial Coronavirus disease 19 infection, Viral pneumonia lingnan fire needle therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) The first affiliated hospital of Guangzhou university of Traditional Chinese medicine China 2020-04-27 2020-12-31 ChiCTR2000032346, ChiMCTR2000003245 Phase 0 Clinical Recruiting 1 8 Months 120 Guohua Lin, Jingchun Zeng 2020-05-08
Neurologic Manifestations of COVID 19 in Children Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) University of Pittsburgh Johns Hopkins University, University of Utah US 2020-04-29 2022-12-31 NCT04379089, STUDY20040154 Phase Not Applicable Recruiting 0 32 Months 500 David Maloney, BS, Ericka L Fink, Ericka L Fink, MD 2020-05-08
COPING: COVID Pandemic Short Interval National Survey Gauging Psychological Distress Acute stress disorder, Coronavirus disease 19 infection Nova Scotia Health Authority Canada 2020-05-31 2022-05-31 COPING, NCT04379063, Temporary REB#25470 Phase Not Applicable Not yet recruiting 1 24 Months 10000 Jonathan Bailey, MD MSc FRCPC 2020-05-08
CovRep: Effector and Regulatory T-Cell Receptor Repertoire Analysis in Patients Affected by COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Assistance Publique Hopitaux de Paris France 2020-05-31 2020-11-30 2020-A01245-34, APHP200544, CovRep, NCT04379466 Phase Not Applicable Not yet recruiting 1 6 Months 60 David KLATZMANN, MD, PhD, Roberta LORENZON, MD 2020-05-08
Rintatolimod and IFN Alpha-2b for the Treatment of Mild or Moderate COVID-19 Infection in Cancer Patients Coronavirus disease 19 infection interferon alfa-2b plus rintatolimod 2,5-Oligoadenylate synthetase stimulator, Interferon alpha ligand modulator, Interferon type I receptor agonist, Ribonuclease stimulator, TLR-3 agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Roswell Park Comprehensive Cancer Center National Cancer Institute US 2020-05-30 2021-04-30 I 659920, I 659920, NCI-2020-02317, NCT04379518, P30CA016056 Phase 1/Phase 2 Clinical Not yet recruiting 0 11 Months 80 Brahm H Segal, Brahm H. Segal 2020-05-11
A phase II study to assess the effect of DW-2008 in the treatment of COVID-19 patients Coronavirus disease 19 infection DW-2008 alone Dong Wha Pharmaceutical Co Ltd 2020-06-30 Phase 2 Clinical Planned 0 2020-05-08
Impact on Anxiety and Motivation of COVID-19 and Predictors of Individual Responses Anxiety disorder, Cognitive disorder, Coronavirus disease 19 infection, Psychiatric disorder Computer task questionnaires alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The National Institute of Mental Health National Institutes of Health Clinical Center US 2020-05-13 2021-02-28 20-M-N112, 999920112, NCT04377100 Phase Not Applicable Not yet recruiting 0 9 Months 500 Monique Ernst, M.D., Morgan Andrews, Ph.D. 2020-05-11
IMPACC: Immunophenotyping Assessment in a COVID-19 Cohort Coronavirus disease 19 infection genome-wide association analysis alone, immunophenotyping alone, serial biological sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institute of Allergy and Infectious Diseases Benaroya Research Center at Virginia Mason, Boston Children's Hospital US 2020-05-01 2021-12-31 DAIT-COVID-19-002, IMPACC, NCT04378777 Phase Not Applicable Recruiting 0 20 Months 2000 Albert C. Shaw, MD, Alejandra Jauregui, Allison Nelson, Carolyn S. Calfee, MD, MAS, Charles B. Cairns, MD, Elaine Reed, PhD, Grace McComsey, MD, Hannah Jin, Hena Din, MPH, Jennifer Sustin, Joanna M. Schaenman, MD, PhD, Kari C. Nadeau, MD, PhD, Karina Oganezova, Komal Srivastava, Laurel Bristow, Lindsey R. Baden, MD, Mariana Bernui, Nadine Rouphael, M.D., Nadine Rouphael, MD, Sarah Siegel, Viviana A. Simon, MD, PhD, William B. Messer, MD, PhD 2020-05-08
SARS-CoV-2 in ESKD Coronavirus disease 19 infection, End stage renal disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitaire Ziekenhuizen Leuven Belgium 2020-04-23 2022-05-01 NCT04378686, S64000 Phase Not Applicable Recruiting 2 24 Months 500 Annelien Van Der Veen, MD, Bjorn Meijers, MD, PhD, Björn Meijers, Helga Wielandt, Koen Stas, MD 2020-05-11
LDCTiP: LDCT in COVID-19 Pneumonia: a Prospective Moscow Study Coronavirus disease 19 infection, Viral pneumonia Low-dose Chest CT alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Federal State Institution "Medical Radiological Research Center" Russian Federation 2020-05-31 2020-07-31 2020-1, LDCTiP, NCT04379531 Phase Not Applicable Not yet recruiting 1 2 Months 230 Anton Vladzymyrskyy, Ivan Blokhin, Valeria Chernina, Victor Gombolevskiy, PhD 2020-05-08
VOC-COVID: Analysis of Volatile Organic Compounds by Electronic Noses in Hospitalized Patients for an Infection by SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection, Respiratory disease electronic nose alone, volatile organic compounds analysis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopital Foch France 2020-04-14 2020-11-16 2020-0060, NCT04379154, VOC-COVID Phase Not Applicable Recruiting 1 7 Months 60 Elisabeth Hulier-Ammar, Hélène Salvator 2020-05-11
A randomized clinical trial for the efficacy and safety of aliskiren and nifedipine in novel coronavirus pneumonia (COVID-19) patients with hypertension Coronavirus disease 19 infection, Hypertension, Viral pneumonia aliskiren alone, nifedipine alone, standard care alone Calcium channel inhibitor L-type, Renin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) West China Hospital China 2020-03-01 2020-12-31 ChiCTR2000032314 Phase 0 Clinical Recruiting 5 10 Months 242 Fengming Luo, Min Zhu 2020-05-08
Evaluation of Clinical Parameters on Admission and Medications in Covid-19 Pneumonia (Corona Virus Disease 2019) (Covid-19) Coronavirus disease 19 infection, Viral pneumonia ACE inhibitor therapy alone, calcium channel blocker therapy alone, computed tomography alone, polymerase chain reaction test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nisantasi University Turkey 2020-05-01 2020-05-08 20200504441, NCT04379310 Phase Not Applicable Recruiting 1 60 Hasan Haciosman, Hasan Haciosman, M.D., Murat Civan, Murat Civan, M.D. 2020-05-08
Vagus Nerve Stimulation ARDS Prevention Trial for COVID-19 Hospitalized Patients Coronavirus disease 19 infection, Lung disease, Respiratory distress syndrome, Viral pneumonia transcutaneous auricular vagus nerve stimulation alone, transcutaneous auricular vagus nerve stimulator (Nemechek Technologies) alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nemechek Technologies 2020-07-31 2021-01-31 NCM-001, NCT04379037 Phase Not Applicable Not yet recruiting 0 6 Months 50 Jean R Nemechek, JD, Patrick M Nemechek, D.O. 2020-05-08
Viral Infections in Healthy and Immunocompromised Hosts Coronavirus disease 19 infection, Viral infection Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs) National Institute of Allergy and Infectious Diseases National Institutes of Health Clinical Center US 2011-03-05 11-I-0109, 110109, NCT01306084 Phase Not Applicable Recruiting 0 164 Jeffrey I Cohen, M.D. 2020-05-11
Peer Champion Support for Hospital Staff During and After the COVID-19 Pandemic Coronavirus disease 19 infection Enriched Survey Feedback alone, Peer Resilience Champion alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mount Sinai Hospital Canadian Institutes of Health Research Canada 2020-06-30 2022-02-28 20-0084-E, NCT04373382 Phase Not Applicable Not yet recruiting 1 20 Months 1000 Robert G Maunder 2020-05-11
Robot Assisted Percutaneous Cardiovascular Intervention as a Strategy to Reduce or Risk of Intra-Procedure Contamination by COVID-19 and Other Respiratory Viruses Cardiovascular disease, Coronavirus disease 19 infection, Ischemic heart disease Robot Assisted Percutaneous Cardiovascular Intervention alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sociedade Beneficente Israelita Brasileira Hospital Albert Einsten Brazil 2020-04-27 2020-04-27 4094-20, NCT04379453 Phase Not Applicable Recruiting 1 10 Marcelo Franken, MD, Pedro A Lemos, MD, Pedro Lemos, MD 2020-05-11
Risks of COVID-19 in the Pregnant Population Coronavirus disease 19 infection Biospecimen collection alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Mayo Clinic Foundation US 2020-05-05 2021-07-31 20-003251, NCT04379284 Phase Not Applicable Not yet recruiting 0 14 Months 100 Ann L VanOosten, Maureen A Lemens, BSN, Regan N Theiler, MD, PhD 2020-05-11
Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Adults With Polypharmacy Using Data From Large Medicare and Commercially Insured Populations Coronavirus disease 19 infection drug therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tabula Rasa HealthCare Inc Cambia Health Solutions Inc US 2020-05-05 2021-04-30 COVID19-TRHC-2020-002, NCT04378881 Phase Not Applicable Not yet recruiting 0 11 Months 100 Pamela Dow, MS, Veronique Michaud, Veronique Michaud, PhD 2020-05-11
UC-COVID: Understanding Community Considerations, Opinions, Values, Impacts, and Decisions for COVID-19 Coronavirus disease 19 infection Brief educational video alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California Los Angeles US 2020-05-31 2020-12-31 NCT04373135, UC-COVID, UCLA-20-000683 Phase Not Applicable Not yet recruiting 0 7 Months 1000 Lauren E Wisk, PhD, Russell G Buhr, MD, PhD 2020-05-11
ILIAD-7-UK: InterLeukin-7 (CYT107) to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection UK Cohort Coronavirus disease 19 infection, Lymphocytopenia CYT-107 alone IL-7 receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Revimmune Inc Amarex Clinical Research 2020-05-11 2020-12-30 CLI107 COVID UK, ILIAD-7-UK, NCT04379076 Phase 2 Clinical Not yet recruiting 0 7 Months 48 Frederique Berbille, MHSc, Manu Shankar-Hari, MD PhD, Michel Morre, DVM MSc 2020-05-10
Analysis of Mortality of Critically Ill Patients With COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario de Getafe Fundación Para La Investigación Biomédica Del Hospital De La Princesa, Hospital General Universitario Gregorio Marañon, Hospital Infanta Cristinam, Hospital Puerta de Hierro Majadahonda, Hospital Universitario Madrid Sanchinarro, Hospital Universitario Ramon y Cajal, Hospital Universitario Severo Ochoa, Hospital Universitario de Mostoles, Hospital de Henares, Hospital de Sant Pau, La Paz University Hospital (Madrid), University Hospital of Torrejon, University of Gregorio Maranon Spain 2020-04-27 2020-05-30 COVID-UCI_SPAIN, NCT04379258 Phase Not Applicable Not yet recruiting 1 1 Month 650 Laura Ojalvo, Oscar Peñuelas, P.h.D 2020-05-10
Hydrogen/Oxygen Mixed Gas Inhalation for Coronavirus Disease 2019 (COVID-19) Coronavirus disease 19 infection, Dyspnea Standard of care alone, hydrogen + oxygen alone, hydrogen oxygen generator (AMS-H-03, Shanghai Asclepius Meditec Co., Ltd., China) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Guangzhou Institute Of Respiratory Disease China 2020-01-21 2020-03-23 JT202005LZ, NCT04378712 Phase 2 Clinical Completed 2 2 Months 90 Wei-jie Guan, PhD 2020-05-11
Unplanned Shifting to Online Distance Learning: Nursing Students' Perception and Achievement (COVID-19) Coronavirus disease 19 infection implimenting Online Distance Learning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kasr El Aini Hospital Egypt 2020-02-01 2020-06-30 FON170133, NCT04372693 Phase Not Applicable Recruiting 1 5 Months 180 Sameh Elhabashy 2020-05-11
Platelet Count, Platelet, Mean Platelet Volume and Platelet Distribution Width in COVID-19 Coronavirus disease 19 infection Konya Training And Research Hospital 2020-05-04 2020-05-13 COVID-19, NCT04378829 Phase Not Applicable Not yet recruiting 0 40 Yasin TİRE 2020-05-11
Nudges to Limit COVID-19 Coronavirus disease 19 infection Behavioral Nudges (BN) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical College of Wisconsin US 2020-05-11 2020-10-10 NCT04379375 Phase Not Applicable Not yet recruiting 0 5 Months 300 Nicholas D Young, PhD 2020-05-11
COVID-BMR: COVID-19 and ICU-acquired MDR Bacteria Bacterial infection, Coronavirus disease 19 infection, Multidrug resistant infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille France 2020-05-31 2021-05-31 2020-A01157-32, 2020_37, COVID-BMR, NCT04378842 Phase Not Applicable Not yet recruiting 1 12 Months 690 Saad Nseir, MD,PhD 2020-05-11
Innovative Tool to Limit Spread of SARS-CoV-2 in Residential Aged Care Facilities Coronavirus disease 19 infection Gamification function alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Queensland 2020-05-06 2020-06-04 CARE COLLECTIVE STUDY, NCT04377165 Phase Not Applicable Not yet recruiting 0 9000 Anna Donaldson, Caitlin Falconer, David L Paterson, PhD 2020-05-11
CORONA: a Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19 Coronavirus disease 19 infection Rexin-G alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aveni Foundation US 2020-06-12 2021-03-12 AF20-203, NCT04378244 Phase 1/Phase 2 Clinical Not yet recruiting 0 9 Months 18 Erlinda M Gordon, MD, Sant P Chawla, MD, Victoria Chua-Alcala, MD 2020-05-11
CON-VINCE: Covid-19 National Survey for Assessing Viral Spread by Nonaffected Carriers Coronavirus disease 19 infection Covid-19 national survey alone, RT-PCR test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Luxembourg Institute of Health BioneXt Lab, Centre Hospitalier de Luxembourg, Ketterthill, Laboratoire National de santé, Laboratoires Réunis, Luxembourg Centre for Systems Biomedicine, Luxembourg National Research Funds, TNS-Ilres, Universite of Luxembourg Luxembourg 2020-04-10 2021-12-31 831X6CE0D, CNER 202004/01, CON-VINCE, FNR/CON-VINCE, NCT04379297 Phase Not Applicable No longer recruiting 1 20 Months 1800 Rejko Krüger, Dr 2020-05-11
BCG Vaccination for Healthcare Workers in COVID-19 Pandemic Coronavirus disease 19 infection BCG vaccine Danish strain 1331 (Statens Serum Institute) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Applied Sciences Inc South Africa 2020-05-04 2021-04-28 NCT04379336, TASK-008 BCG-CORONA Phase 3 Clinical Recruiting 1 11 Months 500 Caryn M Upton, MBChB, Caryn Upton, MD, Christelle Van Niekerk 2020-05-11
FRESH: Fluid Response Evaluation in Sepsis Hypotension and Shock study Coronavirus disease 19 infection, Hypotension, Septic shock Baxter’s Starling Fluid Management Monitoring System alone, Passive Leg Raises alone, vasopressor therapy alone Baxter International Inc UK, US FRESH Phase Not Applicable Status not specified 1 Ivor Douglas 2020-05-08
A Study of Hydroxycholoroquine Compared to Placebo as Treatment for People With COVID-19 Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Memorial Sloan-Kettering Cancer Center US 2020-05-05 2021-05-31 20-187, NCT04379492 Phase 2 Clinical Recruiting 0 12 Months 120 Genovefa Papanicolaou, MD, Susan Seo, MD 2020-05-11
A Study of Trans Crocetin in Patients With Acute Respiratory Distress Syndrome Due to COVID-19 Disease (LEAF-4L7520/4L6715) (LEAF-4L6715) Coronavirus disease 19 infection, Respiratory distress syndrome LEAF-4L6715 alone, LEAF-4L7520 alone, artificial respiratory support therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut de Cancerologie Strasbourg Europe LEAF4Life LLC France 2020-04-14 2020-10-31 2020-001393-30, 2020-003, 2020-A00900-39, NCT04378920 Phase 1/Phase 2 Clinical Recruiting 2 6 Months 180 Manon VOEGELIN, Manon VOEGELIN, PhD, Olivier COLLANGE, PhD MD, Paul Michel MERTES, PhD MD, Valerie SARTORI, Vitaliy CHABAN, MD 2020-05-11
Efficacy and safety of high-dose vitamin C combined with traditional Chinese medicine in the treatment of moderate and severe novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Chinese medicine alone, Buzhong Yiqi Decoction plus vitamin C Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Xi'an International Medical Center Hospital Shaanxi Hospital of Traditional Chinese Medicine China 2020-02-06 2021-01-31 ChiCTR2000032717, ChiMCTR2000003284 Phase Not Applicable No longer recruiting 2 11 Months 60 Xijing He 2020-05-11
High dose intravenous vitamin C might be used as an important rescue therapy for aggravation of severe and critical novel coronavirus pneumonia (COVID-19) patients Coronavirus disease 19 infection, Viral pneumonia vitamin C alone Rui Jin Hospital Science and Technology Commission of Shanghai Municipality China 2020-02-05 2020-04-30 ChiCTR2000032716 Phase Not Applicable No longer recruiting 1 2 Months 12 Bing Zhao, Enqiang Mao 2020-05-11
Assessing Pediatric Food Insecurity During the COVID-19 Pandemic in Austin Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Texas System US 2020-04-10 2021-07-30 2020-004-0019, NCT04378595 Phase Not Applicable Recruiting 0 15 Months 1000 Ana Avalos, MD, Keli Hawthorne, Keli Hawthorne, MS, Megan Gray, MD, Steve Abrams, MD, Steven Abrams 2020-05-11
Prevalence of Long-term Respiratory Complications of Severe SARS-CoV-2 Pneumonia Coronavirus disease 19 infection, Respiratory disorder, Viral pneumonia blood sample and data record alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Reims France 2020-05-15 2021-10-15 NCT04376840, PO20066 Phase Not Applicable Not yet recruiting 1 17 Months 240 Jeanne-Marie PEROTIN-COLLARD 2020-05-11
COM-COVID: Assessment of the Psycho-social Impact of COVID-19 Outbreak Coronavirus disease 19 infection COM-COVID anonimous survey alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundació Institut Germans Trias i Pujol Anaxomics Biotech, Fundació Lluita contra la SIDA Spain 2020-03-31 2020-12-31 COM-COVID, COM-COVID, NCT04378452 Phase Not Applicable Recruiting 3 9 Months 65000 Carol Armengol, PhD, Cris Vilaplana, MD, PhD, José A Muñoz-Moreno, PhD, Judith Farrés, PhD, Lilibeth Arias, PhD, Maria Rosa Sarrias, PhD, Pau Benito, Pere-Joan Cardona, MD, PhD 2020-05-11
A Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 as Addition to Investigator's Choice of Standard of Care Therapy, in Patients With Coronavirus Disease 19 (COVID-19) Coronavirus disease 19 infection standard-of-care antiviral therapy alone, vidofludimus alone, Variable regimens including chloroquine , hydroxychloroquine , vidofludimus Dihydroorotate dehydrogenase inhibitor, IL-17 antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Immunic AG, Immunic Inc FGK Clinical Research GmbH Europe, US 2020-05-31 2020-10-31 NCT04379271, P2-IMU-838-COV Phase 2/Phase 3 Clinical Not yet recruiting 0 5 Months 600 Andreas Muehler, Dr., Neera Ahuja, Prof. 2020-05-11
Safety and Efficacy of Therapeutic Anticoagulation on Clinical Outcomes in Hospitalized Patients With COVID-19 Blood clotting disorder, Coronavirus disease 19 infection, Viral pneumonia enoxaparin sodium plus unfractionated heparin Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Massachusetts General Hospital Beth Israel Deaconess Medical Center, Dartmouth-Hitchcock Medical Center US 2020-05-15 2022-01-01 2020P001136, NCT04377997 Phase 2 Clinical Not yet recruiting 0 19 Months 300 Jaclyn Pagliaro, MPH, Mazen Albaghdadi, MD 2020-05-11
EpiCoV-Brazil: Characteristics and Outcomes of Patients With COVID-19 Admitted to the ICU Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Brazil 2020-05-10 2020-12-31 31382620.0.0000.0068, EpiCoV-Brazil, NCT04378582 Phase Not Applicable Not yet recruiting 1 7 Months 300 Juliana C Ferreira, MD 2020-05-11
GEROCOVIDobs: Geriatric Population COVID-19 Observational Study Coronavirus disease 19 infection Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universita Campus Bio MediCo Di Roma BLUECOMPANION FRANCE, Italian Society of Gerontology and Geriatrics Italy 2020-04-25 2020-11-30 GC01-OBS, GEROCOVIDobs, NCT04379440 Phase Not Applicable Recruiting 7 7 Months 1500 Raffaele Antonelli Incalzi, M.D., Susanna Del Signore, M.D. 2020-05-11
COVIDHIVPrEP: COVID-19 Infection in Patients Infected With HIV and/or on PrEP Coronavirus disease 19 infection, HIV infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2020-04-30 2020-05-04 COVIDHIVPrEP, CRC_GHN_2020_002, NCT04379245 Phase Not Applicable Completed 1 4200 2020-05-11
CLUSCO: Prognostic Value of Point of Care Cardiac and Lung Ultrasound in COVID-19 Coronavirus disease 19 infection, Respiratory failure cardiopulmonary ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Pennsylvania US 2020-04-23 2020-12-31 843008, CLUSCO, NCT04379544 Phase Not Applicable No longer recruiting 0 8 Months 105 Felipe Teran, MD 2020-05-11
Effects of tests for covid-19 on the preservation of the healthcare workforce during pandemic in Brazil Coronavirus disease 19 infection RT-PCR testing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University Hospital of Brasilia Brazil 2020-04-30 3,959,938, 30540720.2.0000.0008, RBR-6w5tbk, U1111-1251-0177 Phase Not Applicable Not yet recruiting 1 250 Cleandro Pires de Albuquerque 2020-05-11
A phase II, randomized, open-label clinical study to assess safety and efficacy of masitinib in combination with isoquercetin in the treatment of hospitalized patients with moderate and severe COVID-19 Coronavirus disease 19 infection isoquercetin plus masitinib CSF-1 antagonist, FGF3 receptor antagonist, Fyn tyrosine kinase inhibitor, Kit tyrosine kinase inhibitor, Lyn tyrosine kinase inhibitor, PDGF receptor antagonist, Protein tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AB Science SA France 2020-05-06 AB20001 Phase 2 Clinical Recruiting 1 200 2020-05-08
A study to assess the efficacy of a imiquimod cream with hydroxychloroquine for primary and secondary prophylaxis of subjects with COVID19 infection Coronavirus disease 19 infection hydroxychloroquine plus imiquimod TLR-7 agonist University of Texas System Phase Not Applicable Planned 0 2020-05-08
Clinical trial on the efficacy of tocilizumab in modifying the inflammatory parameters of patients with COVID-19 Coronavirus disease 19 infection, Viral pneumonia tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal Spain 2020-05-04 2020-002032-69, COVITOZ-01 Phase 2 Clinical Recruiting 1 78 Departamento de Ensayos Clínicos 2020-05-11
ANA-COVID-GEAS: Clinical Trial of the Use of Anakinra (Anti-IL-1) in Cytokine Storm Syndrome (CSS) Secondary to COVID-19 Coronavirus disease 19 infection, Systemic inflammatory response syndrome, Viral pneumonia anakinra alone, standard treatment alone Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundación Pública Miguel Servet Instituto de Salud Carlos III Spain 2020-04-28 2020-001825-29, ANA-COVID-GEAS, ANA-COVID-GEAS Phase 2/Phase 3 Clinical Recruiting 1 180 RUTH GARCIA 2020-05-11
Anxiety and depression during COVID-19 in India Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Super Speciality Hospital India 2020-04-24 CTRI/2020/04/024784 Phase Not Applicable Not yet recruiting 1 1000 Dr Sameer Malhotra, Sameer Malhotra, Shreya Singhal 2020-05-11
A study to assess the effect of Ternatin-4 in patients with Covid-19 Coronavirus disease 19 infection Ternatin-4 alone University of California San Francisco Phase Not Applicable Planned 0 2020-05-07
SoDi: Neuroendocrine mechanisms, Social isolation and psychobiological stress during the COVID-19 pandemic Acute stress disorder, Coronavirus disease 19 infection, Social phobia psychotherapeutical counselling alone, smartphone application alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Heidelberg Germany 2020-04-03 DRKS00021671, S-214/2020, SoDi Phase Not Applicable Recruiting 1 200 Ekaterina Schneider, Monika Eckstein 2020-05-11
A study to assess the effect of zotatifin in patients with Covid-19 Coronavirus disease 19 infection zotatifin alone Eukaryotic initiation factor 4A-I inhibitor University of California San Francisco Phase Not Applicable Planned 0 2020-05-08
COVID-19 DETOUR: Detection of a delayed Treatment of urgent ophthalmologic Treatment during the SARS-CoV-2 pandemic (COVID-19) Coronavirus disease 19 infection, Ocular disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitatsklinikum Schleswig-Holstein Campus Kiel Klinik für Augenheilkunde, Germany Germany 2020-05-08 20-477, COVID-19 DETOUR, DRKS00021630 Phase Not Applicable Not yet recruiting 1 30 Christoph Ehlken 2020-05-11
Control of inflammatory parameters with fish oil in parenteral nutrition Coronavirus disease 19 infection, Respiratory tract infection Variable regimens including ClinOleic , Nutriflex Lipid special , Olimel N9 , Omegaflex special , Omegaven , Smofkabiven , Smoflipid Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Vall D'Hebron Spain 2020-04-26 01-2020, 2020-000705-86 Phase 4 Clinical Recruiting 1 117 DAVID BERLANA, David Berlana 2020-05-11
EMBELLIE: Barrier Measures to Limit COVID-19 Nosocomial Transmission: a Cross-sectional Evaluation Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-04-01 2020-12-30 EMBELLIE, NCT04376944, RECHMPL20_0261 Phase Not Applicable Recruiting 1 8 Months 300 Alain MAKINSON, MCU-PH, Marie Bistoquet, MB, Marie Bistoquet, MD 2020-05-08
CORTIVID: Early Treatment Of Pneumonia COVID-19 With Glucocorticoids: Randomized, Controlled Clinical Trial Coronavirus disease 19 infection, Viral pneumonia methylprednisolone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundación Pública Miguel Servet Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas Spain 2020-04-30 2020-001827-15, CORTIVID, CORTIVID Phase 3 Clinical Recruiting 1 72 CLINICAL TRIAL UNIT 2020-05-11
Heparin-SARS-CoV2: Impact of the use of low molecular weight heparins (LMWH), at prophylactic versus intermediate doses, on SARS-CoV2 infection (COVID-19) Coronavirus disease 19 infection enoxaparin sodium alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion Neumosur Spain 2020-05-04 2020-001891-14, Heparin-SARS-CoV2, Heparin-SARS-CoV2 Phase 2 Clinical Recruiting 1 140 Alejandro 2020-05-11
MindCOVID: Risk Factors for Anxiety and Depression Among Pregnant Women During the COVID-19 Pandemic Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zelazna Medical Centre, LLC American University of Beirut Medical Center, Central Clinical Hospital of the Internal Affairs and Administration Ministry, Chang Gung University, Charite University, Charles University, Chinese University of Hong Kong, Fundación Para la Investigación y el Desarrollode la Medicina Materno-Fetal y Neonatal “iMaterna”, Hopital Necker Enfants Malades, Karolinska Institutet, Medical Center of Postgraduate Education, Meir Medical Center, Nicolaus Copernicus University, Polish Academy of Sciences, Pomeranian Medical University, Royal Prince Alfred Hospital, Taiji Clinic, Universita degli Studi di Brescia, University of Medicine, Tirana, University of Tromso, Wayne State University Sweden, Germany, Israel, Taiwan, Czech Republic, Hong Kong, Poland, France, Italy, US, Norway, Albania, Spain, Australia, Lebanon 2020-05-01 2020-10-31 MATERNAL AXIETY AND COVID-19, MindCOVID, NCT04377412 Phase Not Applicable Recruiting 16 6 Months 8500 Anna Kajdy, Anna Kajdy, MD, PhD, Artur Pokropek, PhD, Professor, Barbara Baranowska, PhD, RM, Dariusz Borowski, MD, PhD, Dorota Sys, PhD, Equal Chen, Ewa Andersson, RNM, PhD, Federico Prefumo, MD, PhD, Ganesh Acharya, MD, PhD, FRCOG, Professor, Ganesh Archaya, MD, PhD, Professor, Gihad Chalouhi, MD, PhD, Heidi Tiller, MD, PhD, Jade Harris, MD, Jan Modzelewski, MD, Jon Hayett, Professor, Jon Hyett, Karine Stiberg Birkelund, Ksenia Olisova, MD, MPH, Laurent J Salomon, MD, PhD, Laurent J Salomon, MD, PhD, Professor, Liona C Poon, MBBS, MRCOG, Professor, Maria del Mar Gil Mira, MD, PhD, Maya Ben-Zion, MD, Michał Rabijewski, MD, PhD, Professor, Orion Gliozheni, MD, Pavel Calda, MD, MSc, Professor, Roksana Lewandowska, MD, Sebastian Kwiatkowski, MD, PhD, Simone Schwank, PhD M.S. M.A. Msc. Clinical Ps, Solrun Rasmussen, Sonia Hassan, MD, Stefan Verlohren, MD, Professor, Stepan Feduniw, MD, Steven Shaw, Tal Biron-Shental, MD, Tung-Yao Chang, MD, M Med Sci, Urszula Ajdacka, MD, pavel Calda, MD, MSc. 2020-05-11
Tocilizumab Versus Methylprednisolone in the Cytokine Release Syndrome of Patients With COVID-19 Coronavirus disease 19 infection, Inflammatory disease tocilizumab alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Sao Domingos Brazil 2020-05-31 2020-11-30 COVID-19 HSD, NCT04377503 Phase 2 Clinical Not yet recruiting 1 6 Months 40 HUGO C LIMA, MD, JOSE A AZEVEDO, MD, PhD, PEDRO B FROTA, MD 2020-05-07
Use of the Nasal Cannula During COVID-19 Coronavirus disease 19 infection low flow nasal cannula alone Healthy volunteers accepted Asociación de Anestesia Analgesia y Reanimación de Buenos Aires (AAARBA) Argentina 2020-04-30 2020-09-30 NASAL CANNULAS FLOW RATE, NCT04376580 Phase Not Applicable Recruiting 1 5 Months 100 Carolina Frederico 2020-05-08
Parental Stress During the COVID-19 Pandemic and Its Association With Depression and Anxiety Acute stress disorder, Coronavirus disease 19 infection, Depression, Generalized anxiety disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oslo Modum Bad, Oslo and Akershus University College of Applied Sciences Norway 2020-03-31 2020-04-07 NCT04377074, REK125510(3) Phase Not Applicable Completed 1 2880 Asle Hoffart, PhD, Miriam Sinkerud Johnson, PhD, Nora Paulsen Skjerdingstad, Omid Ebrahimi, Sverre Urnes Johnson, PhD 2020-05-11
Fluoxetine to Reduce Intubation and Death After COVID19 Infection Coronavirus disease 19 infection fluoxetine hydrochloride alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of Toledo Health Science Campus US 2020-05-01 2021-10-20 FRIDA COVID19, NCT04377308 Phase 4 Clinical Recruiting 0 17 Months 2000 Cheryl McCullumsmith, MD PhD, Cheryl Mccullumsmith 2020-05-08
FORECAST: Finding Out if COVID-19 Infection Can be predicted by Changes in Smell and/or Taste Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University College London UK 2020-04-23 2020-12-23 132311, 20/HRA/1879, FORECAST, NCT04377815 Phase Not Applicable Recruiting 2 8 Months 500 Alisia Carnemolla, PhD, Rachel L Batterham, PhD 2020-05-07
The Use of Tocilizumab in the Management of Patients Who Have Severe COVID-19 With Suspected Pulmonary Hyperinflammation Coronavirus disease 19 infection, Hypoxia, Lung inflammation, Respiratory failure, Viral pneumonia tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hadassah Medical Organization Sheba Medical Center, Wolfson Medical Center Israel 2020-04-08 2021-05-08 0224-20-HMO-CTIL, NCT04377750 Phase 4 Clinical Recruiting 4 13 Months 500 Eithan Galun, Prof., Galia Rahav, Prof., Juli Benbenisty, MPH, Reuven Pizov, Prof., Shlomo Maayan, PROF, Yasmin Meir, Dr. 2020-05-08
COVID-Milit: A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers Coronavirus disease 19 infection hydroxychloroquine plus zinc Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hopital Militaire Principal d'instruction de Tunis Dacima Consulting, UR17DN02 : Autoimmune Diseases Research Unit Tunisia 2020-05-04 2020-07-31 COVID-Milit, NCT04377646, TN2020-NAT-INS-38, UR17DN02-001 Phase 3 Clinical Not yet recruiting 1 2 Months 660 Faida Ajili, MD, Neja Stambouli, PhD, Nejla Mrabet, PhD, Nejla Stambouli, PhD 2020-05-07
OSCAR: Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease Coronavirus disease 19 infection, Lung disease, Viral pneumonia otilimab alone, standard of care alone GM-CSF receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) GlaxoSmithKline plc 2020-05-18 2020-12-20 214094, NCT04376684, OSCAR Phase 2 Clinical Not yet recruiting 0 7 Months 800 EU GSK Clinical Trials Call Center, GSK Clinical Trials, US GSK Clinical Trials Call Center 2020-05-11
PRED ICU COVID19: Predicting the Need for Intubation in Hospitalized COVID-19 Patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France France 2020-05-31 2020-11-30 2020-A01076-33, NCT04376879, PRED ICU COVID19 Phase Not Applicable Not yet recruiting 2 6 Months 384 Antoine KIMMOUN, MD-PhD, Jean Damien RICARD, MD-PhD, Julie JOSSE, PhD, Patrick ROSSIGNOL, MD-PhD 2020-05-11
Human Convalescent Plasma for High Risk Children Exposed or Infected With SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection anti-SARS-CoV-2 human convalescent plasma alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Johns Hopkins University US 2020-05-18 2022-05-18 IRB00247557, NCT04377672 Phase 1 Clinical Not yet recruiting 0 24 Months 30 Mary Katherine Brosnan, Oren Gordon, MD, Sanjay K Jain, MD 2020-05-11
COVID-CT: Prediction of Clinical Course in COVID-19 Patients Coronavirus disease 19 infection computed tomography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Saint Etienne Centre National de la Recherche Scientifique (CNRS), INSERM, Institut National Des Sciences Appliquées, Universite Jean Monnet, University of Lyon France 2020-03-01 2020-09-30 20CH096, 20CH109, COVID-CT, NCT04377685 Phase Not Applicable Recruiting 1 7 Months 800 Beatrice DEYGAS, Pierre CROISILLE, PhD 2020-05-11
PiCCOVID: Extra Vascular Lung Water and Pulmonary Permeability in Critically Ill Patients With SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection transpulmonary thermodilution alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-04-01 2020-09-30 NCT04376905, PiCCOVID, RECHMPL20-0193 Phase Not Applicable Recruiting 1 6 Months 30 Fanny Garnier, chef de clinique, Kada KLOUCHE, MD PhD 2020-05-08
RUXCOVID-DEVENT: Assessment of Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation Coronavirus disease 19 infection, Respiratory distress syndrome Standard of care alone, ruxolitinib (oral, myeloproliferative disorders), Incyte/Novartis alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Incyte Corp, Novartis AG US 2020-05-06 2020-07-29 INCB 18424-369, NCT04377620, RUXCOVID-DEVENT Phase 3 Clinical Not yet recruiting 0 2 Months 500 Incyte Corporation Call Center (US) 2020-05-11
Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS) Coronavirus disease 19 infection, Respiratory distress syndrome allogeneic bone marrow-derived human mesenchymal stem (stromal) cells (MSCs) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Tubingen Germany 2020-05-31 2021-02-28 NCT04377334, RESCOVID Phase 2 Clinical Not yet recruiting 1 9 Months 40 Peter Rosenberger, MD, Peter Rosenberger, Prof., Valbona Mirakaj, Prof. 2020-05-11
CoronaWatch: Early Detection of Cardiovascular Risks in COVID-19 Via SmartWatch Cardiovascular disease, Coronavirus disease 19 infection, Heart arrhythmia Apple watch series 5 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Heidelberg Deutsche Herzstiftung eV, Freunde und Förderer der Kardiologie Heidelberg, Klaus Tschira Stiftung GmbH Germany 2020-04-15 2020-07-31 CORONAWATCH, CoronaWatch, NCT04376853 Phase Not Applicable Recruiting 1 3 Months 50 Benjamin Meder, Prof. Dr. 2020-05-07
ECHOVID-19: The Role of Ultrasound in COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Gentofte Denmark 2020-03-31 2021-03-01 ECHOVID-19, H-20021500, NCT04377035 Phase Not Applicable Recruiting 1 11 Months 1000 Tor Biering-Sørensen, MD, PhD, MPH, Tor Biering-sørensen, MD, PhD, MPH 2020-05-11
PANDEMIC study: Patient’s knowledge And behavior oN the COVID-19 disease and as DEterMInants of Contamination Coronavirus disease 19 infection questionnaires alone Franciscus Gasthuis & Vlietland Netherlands 2020-04-22 2020-08-21 NL8563, PANDEMIC study Phase Not Applicable Recruiting 1 4 Months 170 Hanna van der Valk 2020-05-11
Bioelectric Impedance Analysis in COVID-19 positive patients. A prospective prevalence study Coronavirus disease 19 infection Bioelectric Impedance Analysis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ziekenhuis Gelderse Valle Netherlands 2020-04-01 2020-04-30 NL8562 Phase Not Applicable No longer recruiting 1 1 Month 50 Rianne Slingerland 2020-05-11
Safe Return to Regular Clinical Operation After COVID-19 Pandemic Coronavirus disease 19 infection ARCHITECT i2000SR system alone, RealStar SARS-CoV-2 RT-PCR Kit RUO (Altona Diagnostics) alone, SARS-CoV-2 IgG assay kit (Abbott Diagnostics) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) King Fahad Specialist Hospital Dammam Saudi Arabia 2020-05-17 2020-12-30 KFSH-ONC-02, NCT04377802 Phase Not Applicable Not yet recruiting 1 7 Months 400 Fahad Ibnshamsah, MD, Hani Al Hashmi, MD, Salem Ghandourah, PhD 2020-05-08
Convalescent Plasma Collection and Treatment in Pediatrics and Adults Coronavirus disease 19 infection, Dyspnea convalescent plasma alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) West Virginia University US 2020-04-16 2021-03-30 2004965705, NCT04376034 Phase 3 Clinical Recruiting 0 11 Months 240 Brian Peppers, DO, PhD, Lisa Giblin Sutton, PharmD 2020-05-07
Attention Bias Modification for Reducing Health Anxiety During the Coronavirus Pandemic Anxiety disorder, Coronavirus disease 19 infection Attention Bias Modification (ABM) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tel Aviv University Israel 2020-04-23 2020-04-30 NCT04365972, TAU-COVID-19 Phase Not Applicable Completed 1 20 Yair Bar-Haim, PhD 2020-05-11
Tocilizumab for Prevention of Respiratory Failure in Patients With Severe COVID-19 Infection Coronavirus disease 19 infection, Respiratory failure tocilizumab alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Memorial Sloan-Kettering Cancer Center US 2020-05-01 2021-05-01 20-185, NCT04377659 Phase 2 Clinical Recruiting 0 12 Months 40 Ann Jubowski, MD, Boglarka Gyurkocza, MD 2020-05-11
COVID: Survey: COVID-19 Patients Managed in the Operating Theatre of Belgian Hospitals Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clinique Universitaires Saint-Luc, Universite Catholique de Louvain Society for Anesthesia and Resuscitation of Belgium Belgium 2020-04-06 2020-09-30 COVID, COVID-ANESTHESIO, NCT04376398 Phase Not Applicable Recruiting 1 5 Months 200 Mona Momeni, MD, PhD, Vincent Bonhomme, MD, PhD 2020-05-07
COVID-BCG: Randomized, controlled trial evaluating the efficacy of vaccination with Bacillus Calmette and Guerin (BCG) in the Prevention of COVID-19 via the strengthening of innate immunity in Health Care Workers Coronavirus disease 19 infection VACCIN BCG AJVaccines alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris French Health Ministry France 2020-04-28 2020-001678-31, APHP200462, COVID-BCG Phase 3 Clinical Recruiting 1 1120 Assistance Publique Hopitaux de Paris 2020-05-08
HPI-COVID-19: Host-pathogen Interactions During SARS-CoV-2 Infection Coronavirus disease 19 infection, Viral pneumonia biological sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hospices Civils De Lyon France 2020-05-05 2021-06-05 2020-A01102-37, 69HCL20-0342, HPI-COVID-19, NCT04376476 Phase Not Applicable Recruiting 12 13 Months 450 Aurélie PORTEFAIX, MD,PhD, Christèle GRAS-LE-GUEN, PU,PH, Clémence JARRASSE, MD,PhD, Cyrille CONFAVREUX, PU,PH, Etienne JAVOUHEY, PU,PH, Florent VALOUR, PhD, Guillaume MORTAMET, MD,PhD, Hervé LOBBES, MD,PhD, Hugues PATURAL, PU,PH, Marie BAILS-DE-GEORGES, MD,PhD, Nicolas JORAM, MD,PhD, Philippe REBAUD, MD,PhD, Romain BASMACI, PU,PH, Sébastien COURAUD, PU,PH, Thomas BARBA, MD,PhD, Thomas JULLIEN, PhD, Tiphanie Ginhoux, Vincent COTTIN, PU,PH, Yvan JAMILLOUX, PhD 2020-05-11
COVID-19 - Quality of Life After Infection Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Chinese University of Hong Kong Hong Kong 2020-05-05 2022-04-30 NCT04377464, NTEC-2020-0227 Phase Not Applicable Not yet recruiting 2 23 Months 200 Colin Graham, MD, MPH, Joseph Walline, MD 2020-05-08
SLO-COVID-19: Slovenian National COVID-19 Prevalence Study Coronavirus disease 19 infection nasopharyngeal sampling alone University Of Ljubljana Slovenia 2020-04-20 2020-12-31 NCT04376996, SLO-COVID-19, ULMF2020-COVID-19 Phase Not Applicable Recruiting 1 8 Months 3000 Mario Poljak, MD, PhD, Polona Maver Vodicar, MD, PhD 2020-05-08
Exchange Transfusion Versus Plasma From Convalescent Patients With Methylene Blue in Patients With COVID-19 Coronavirus disease 19 infection, Lung disease antihistamine therapy alone, standard of care alone, Variable regimens including convalescent plasma , epinephrine , low-molecular-weight heparin , methyl prednisone , methylene blue , packed washed RBC Adrenergic receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ain Shams University Egypt 2020-05-05 2020-06-01 FMASU P22/2020, NCT04376788 Phase 2 Clinical Not yet recruiting 1 15 Essam A Hassan, MD, Mohamed M Moussa, Mohamed M Moussa, MD 2020-05-11
THROMBCOVID2: Thrombo Embolic Events in Hospitalized Patients With Covid-19 Serious Acute Pneumopathy Coronavirus disease 19 infection, Thromboembolism, Viral pneumonia blood sampling alone, venous ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens France 2020-05-04 2020-11-30 2020-A01084-35, NCT04377490, PI2020_843_0040, THROMBCOVID2 Phase Not Applicable Recruiting 1 6 Months 100 Claire Andrejak, Pr, Julien Maizel, Pr, Michel Slama, Pr, Philippe Lanoix, Pr, Simon Soudet, MD, Valery Salle, MD, Yoann Zerbib, MD 2020-05-11
COVID-19 infections in health care workers Coronavirus disease 19 infection Franciscus Gasthuis & Vlietland Netherlands 2020-05-01 2020-12-31 NL8570, R20.030 Phase Not Applicable Not yet recruiting 1 8 Months 300 Hans Koeleman 2020-05-08
ReCOVER: Evaluation of a remote monitoring smartphone application and care model of COVID-19 patients in the community Coronavirus disease 19 infection TCC-COVID alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Health South Eastern Sydney Local Health District, University of New South Wales Australia 2020-04-28 2021-04-30 ACTRN12620000524998, ReCOVER Phase Not Applicable Not yet recruiting 4 12 Months 2000 Dr Sze-Yuan Ooi 2020-05-08
A clinical study of CardiALLO cell therapy for the treatment of COVID-19 infection related Acute Respiratory Distress Syndrome Coronavirus disease 19 infection, Respiratory distress syndrome CardiALLO cell therapy alone BioCardia Inc Phase Not Applicable Planned 0 2020-05-08
A Study of the Safety and Efficacy of Ciclesonide in the Treatment of Non-hospitalized COVID-19 Patients Coronavirus disease 19 infection ciclesonide (metered dose inhaler), Teijin/Covis/AstraZeneca alone Glucocorticoid receptor agonist Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Covis Pharma Sarl 2020-05-26 2020-12-01 ALV-020-001, NCT04377711 Phase 3 Clinical Not yet recruiting 0 6 Months 400 2020-05-08
COVID-19 Health Messaging Efficacy and Its Impact on Public Perception, Anxiety and Behavior Anxiety disorder, Coronavirus disease 19 infection, Psychiatric disorder health messaging alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Milton S. Hershey Medical Center Huck Institutes of the Life Sciences, The College of Healthcare Information Management Executives (CHIME), The Department of Family and Community Medicine, Penn State College of Medicine, The Social Science Research Institute, US US 2020-04-09 2020-05-31 NCT04377581, STUDY00014798 Phase Not Applicable Recruiting 0 1 Month 25000 Erin McGinley, Erin McGinley, MD, JD, Robert P Lennon, MD, JD, Sherry Tate 2020-05-11
NCoS: Neonatal CoVID-19 Study to evaluate the population health impacts of COVID-19 in mothers and their newborn infants cared for in tertiary and non-tertiary hospitals in Australia Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Hunter New England Health Sydney Childrens Hospital Australia 2020-05-01 2022-11-30 ACTRN12620000527965, NCoS, U1111-1250-9525 Phase Not Applicable Not yet recruiting 7 31 Months 1000 Dr Javeed Travadi 2020-05-08
PET/CT Imaging in COVID-19 Patients Coronavirus disease 19 infection, Lung injury 18F-alphavbeta6-BP alone, computed tomography (CT) alone, positron emission tomography (PET) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California Davis US 2020-05-31 2022-05-31 1592298, NCT04376593 Phase 0 Clinical Recruiting 0 24 Months 10 Julie L. Sutcliffe 2020-05-07
COVIDECOLE: Incidence of COVID-19 in School Children Coronavirus disease 19 infection RT-PCR alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs) Fondation Lenval France 2020-05-15 2020-09-30 20-HPNCL-02, COVIDECOLE, NCT04377737 Phase Not Applicable Not yet recruiting 1 4 Months 914 Anne-Laure HERISSE, Antoine TRAN, Antoine TRAN, MD, Diane DEMONCHY, Hervé HAAS, Hervé HAAS, MD, Lisa GIOVANNINI-CHAMI, Sarah MARCHAL 2020-05-08
CoV-ETH: Spread And Course Of COVID-19 Infections Coronavirus disease 19 infection serological testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) ETH Zurich Switzerland 2020-04-27 2021-06-30 20-05, CoV-ETH, NCT04377724 Phase Not Applicable Recruiting 1 14 Months 3000 Christoph Kolling, MD, Goldhahn Jorg, Jörg Goldhahn, MD 2020-05-11
Hemoglobin Concentration on COVID-19 Coronavirus disease 19 infection, Viral pneumonia Nevsehir Public Hospital Konya Training And Research Hospital Turkey 2020-05-10 2020-05-30 145/2020, NCT04377607 Phase Not Applicable Recruiting 1 200 Ahmet Yasin, Mehmet Akif Yazar, Yasin Tire 2020-05-07
CONCOR-KIDS: Efficacy of Human Coronavirus-immune Convalescent Plasma for the Treatment of COVID-19 Disease in Hospitalized Children Coronavirus disease 19 infection COVID-19 convalescent plasma (C19-CP) alone, standard of care alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) C17 Council, Hospital for Sick Children Canada 2020-05-01 2022-05-01 1000070143, CONCOR-KIDS, NCT04377568 Phase 2 Clinical Not yet recruiting 12 24 Months 100 Anne Pham-Huy, Ari Joffe, Carol Portwine, Christoph Licht, Geoff Cuvelier Cuvelier, Julia Upton, Julia Upton, MD, MPH, Julie Autmizguine, Karina Top, Kathy Brodeur-Robb, Kirk Leifso, Kyla Hildebrand, Nancy Nashid, Peter Gill, MD, Rupeena Purewal, Sergio Fanella, Tammie Dewan 2020-05-07
Quality of Life and Patient-centered Outcomes After Hospitalization for COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome extracorporeal membrane oxygenation alone, high flow nasal cannula alone, mechanical ventilation alone, nasal catheter alone, noninvasive ventilation alone, oxygen alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto de Educação e Pesquisa do Hospital Moinhos de Vento Beneficencia Portuguesa of Sao Paulo, Brazilian Clinical Research Institute, Brazilian Research In Intensive Care Network, Hospital Alemao Oswaldo Cruz, Hospital do Coracao, Sociedade Beneficente Israelita Brasileira Hospital Albert Einsten, Sociedade Beneficiente De Senhoras Hospital Sirio Libanes Brazil 2020-06-15 2021-09-15 COALITION COVID-19: LONG-TERM, NCT04376658 Phase Not Applicable Not yet recruiting 1 15 Months 1000 Maicon Falavigna, MD, Regis G Rosa, MD 2020-05-08
Neuro-Covid: COVID-19 Prevalence and Cognitive Deficits in Neurological Patients Cognitive disorder, Coronavirus disease 19 infection, Epilepsy, Neurological disease, Seizure disorder, Stroke COVID-19 PCR swab test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aarhus University Hospital Denmark 2020-05-07 2022-06-30 NCT04377425, NEURO-COVID-19, Neuro-Covid Phase Not Applicable Not yet recruiting 4 25 Months 100 Boris Modrau, Boris Modrau, MD, Grethe Andersen, MD, Grethe Andersen, MD, DMSc, Lene Rosendahl, MD, Morten Stilund, MD, PhD, Rolf Blauenfeldt, MD 2020-05-11
Observational Study Concerning COVID-19 Infection in Transplanted Kidney, Pancreas or Pancreatic Islet Patients Coronavirus disease 19 infection, Kidney transplantation, Pancreas transplantation, Transplantation Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) IRCCS San Raffaele Italy 2020-05-04 2020-05-18 COVID-19 MITRA, NCT04377776 Phase Not Applicable Recruiting 1 700 Antonio Secchi, Federica Pazzi, Paola Maffi, Rossana Caldara 2020-05-11
Effect of Quercetin on Prophylaxis and Treatment of COVID-19 Coronavirus disease 19 infection Quercetin alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istanbul Bakirkoy Maternity and Children Diseases Hospital Turkey 2020-03-20 2020-08-31 KSSEAH--0058, NCT04377789 Phase Not Applicable Recruiting 2 5 Months 50 Hasan Onal, Hasan Onal, Professor, Seda Yilmaz Semerci 2020-05-09
SEROCOV: Development and Evaluation of Serological Assays for COVID-19 Coronavirus disease 19 infection serological assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-05-31 2020-10-31 20MWI-SEROCOV, NCT04377763, SEROCOV Phase Not Applicable Not yet recruiting 1 5 Months 500 Marie-Anne RAMEIX-WELTI, MD, PhD 2020-05-11
COLOR-19: COVID-19 Pneumonitis Low Dose Lung Radiotherapy Coronavirus disease 19 infection, Viral pneumonia Single fraction whole lung radiotherapy (0.7 Gy) alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Italy 2020-05-10 2022-07-23 COLOR-19, NCT04377477, NP 4097 Phase Not Applicable Recruiting 1 26 Months 30 Davide Tomasini, MD, Stefano M Magrini, Prof 2020-05-11
COWAIT: Assessment of the Impact of COVID-19 on Transplant Patients and on Patients Awaiting Transplantation Coronavirus disease 19 infection, Heart transplantation, Kidney transplantation, Liver transplantation, Lung transplantation, Pancreas transplantation patient-completed survey alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Bordeaux Societe Francophone de Transplantation France 2020-05-15 2020-12-15 CHUBX 2020/19, COWAIT, NCT04376775 Phase Not Applicable Not yet recruiting 1 7 Months 2000 Lionel COUZI, Pr 2020-05-07
A clinical study of JS-016 in treatment of patients with COVID-19 Coronavirus disease 19 infection JS-016 alone COVID19 Spike glycoprotein inhibitor Eli Lilly & Co, Shanghai Junshi Biosciences Co Ltd US 2020-12-31 Phase Not Applicable Planned 0 2020-05-08
Surgical Telemedicine in the COVID-19 Pandemic Era Coronavirus disease 19 infection telemedicine program alone Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) University of Colorado, Denver, US US 2020-06-01 2020-12-31 20-1177, NCT04376710 Phase Not Applicable Not yet recruiting 0 7 Months 100 2020-05-07
A study to evaluate REGN-COV2 for the prevention and treatment of SARS-CoV-2 Coronavirus disease 19 infection REGN-COV2 alone Regeneron Pharmaceuticals Inc 2020-06-30 Phase Not Applicable Planned 0 2020-05-07
COVID-19 MMR: A study to assess the use of MMR vaccine for the treatment of COVID-19 infection Coronavirus disease 19 infection MMR vaccine alone World Health Organization COVID-19 MMR Phase Not Applicable Status not specified 0 Dr. Larry P. Tilley, Jeff Gold 2020-05-08
Correlation Between Oxidative Stress Status and COVID-19 Severity Coronavirus disease 19 infection, Hypoxia ELISA alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-04-20 2020-07-01 NCT04375137, SBMU.12543 Phase Not Applicable Recruiting 1 2 Months 90 Dalili, Nooshin Dalili, Nooshin Dalili, Dr, nooshin dalili 2020-05-08
TRIIM-X: Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial Aging, Cancer, Cardiovascular disease, Coronavirus disease 19 infection, Dementia, Diabetes mellitus, Infectious disease, Influenza virus infection Variable regimens including DHEA , metformin hydrochloride , somatropin AMP activated protein kinase stimulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Intervene Immune Inc US 2020-10-31 2022-10-31 NCT04375657, TRIIM-X, TRIIM-X Phase 2 Clinical Recruiting 0 24 Months 85 Gregory M Fahy, PhD, Robert Brooke 2020-05-08
Community Pharmacists Behavior During Covid-19 Coronavirus disease 19 infection face to face interview alone, semi-structured telephone interview alone Damanhour University Egypt 2020-05-02 2021-04-30 NCT04374513, PHARMACISTS AND COVID-19 Phase Not Applicable Recruiting 2 11 Months 50 Amira Kassem, PhD, Amira Kassem, phD, Asser Ghoneim, phD, Noha El Bassiouny, PhD 2020-05-07
The effect of addition of selenium to treatment regimen of hospitalized patients with corona on the outcome of disease compared with control group Coronavirus disease 19 infection antibiotic therapy alone, antiretroviral therapy alone, selenium alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sabzevar University of Medical Sciences Iran 2020-05-20 IR.MEDSAB.REC.1399.017, IRCT20160706028815N5 Phase 2 Clinical Not yet recruiting 1 40 Afsaneh Kaffash, Fereshteh Ghorat 2020-05-07
I-SPY COVID: A clinical trial to rapidly identify therapies to treat acute respiratory distress syndrome (ARDS) in critically ill COVID-19 patients Coronavirus disease 19 infection, Respiratory distress syndrome standard-of-care alone QuantumLeap Healthcare, University of California San Francisco US I-SPY COVID Phase Not Applicable Status not specified 0 Laura Esserman 2020-05-07
Less Frequency Hemodialysis and COVID-19 Coronavirus disease 19 infection, Kidney dialysis less-frequency hemodialysis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dialisis Madariaga Argentina 2020-03-20 2021-03-31 CORONAVIRUS, NCT04374058 Phase Not Applicable No longer recruiting 1 12 Months 50 Esteban L Siga, MD 2020-05-07
A first in human clinical trial of DPX-COVID-19 for the potential prevention of COVID-19 Coronavirus disease 19 infection DPX-COVID-19 alone McGill University Health Center Fonds de solidarité FTQ 2020-07-31 Phase Not Applicable Planned 0 2020-05-06
Early Short Course Corticosteroids in COVID-19 Coronavirus disease 19 infection, Viral pneumonia antibiotic therapy alone, antiviral therapy alone, high-flow nasal cannula therapy alone, mechanical ventilation therapy alone, renal-replacement therapy alone, standard care alone, supportive care alone, Variable regimens including hydroxychloroquine , lopinavir , methylprednisolone , remdesivir , ritonavir Coronavirus non structural protein 8 modulator, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Henry Ford Health System US 2020-03-12 2020-04-30 HFH IRB # 13739, NCT04374071 Phase Not Applicable Completed 0 1 Month 250 Dr. Mayur S. Ramesh 2020-05-08
Level and Predictors of Trauma-symptoms Among Health Workers and Public Service Providers During the COVID-19 Outbreak Anxiety disorder, Coronavirus disease 19 infection, Depression, Injury, Post traumatic stress disorder Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oslo Modum Bad Norway 2020-03-31 2020-04-07 NCT04374097, REK125510(2) Phase Not Applicable Completed 1 1778 Asle Hoffart, PhD, Omid Ebrahimi, Sverre Urnes Johnson, PhD 2020-05-07
PROVID: PROne Positioning in coVID-19 Oxygeno-dependent Patients in Spontaneous Ventilation (PROVID Study) Coronavirus disease 19 infection Prone positioning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-04-30 2020-07-31 APHP200504, NCT04366856, PROVID Phase Not Applicable Not yet recruiting 1 3 Months 500 Anatole HARROIS, Anatole HARROIS, MD, Anatole HARROIS, MD, PhD 2020-05-07
Clinical trial of anti-SARS-CoV-2 antibodies (COVID-19), Formycon for the treatment of Covid-19 Coronavirus disease 19 infection anti-SARS-CoV-2 antibodies (COVID-19), Formycon alone Formycon AG 2021-09-30 Phase Not Applicable Planned 0 2020-05-08
Pulmonary Rehabilitation in Post-Acute Period of COVID-19 Infection Anxiety disorder, Coronavirus disease 19 infection, Depression, Dyspnea, Fatigue, Myalgia Pulmonary Rehabilitation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Istanbul Bilgi University Turkey 2020-03-11 2020-04-26 NCT04365738, PR COVID-19 Phase Not Applicable Completed 1 1 Month 270 Tomri̇s Duymaz 2020-05-07
Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP Could be Promising COVID-19 Infection- and Lung Injury Preventing Drug Better Than Recombinant Human ACE2 (Bacterial ACE2) Coronavirus disease 19 infection, Lung injury recombinant bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2) alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kafrelsheikh University Egypt 2020-08-31 2020-10-31 NCT04375046, PROPOSED BY MAHMOUD KAZAZZAZ Phase 1 Clinical Not yet recruiting 1 2 Months 24 M.Sc. Mahmoud Elkazzaz, M.Sc.Biochemistry, M.Sc.Mahmoud Elkazzaz, M.Sc.Biochemistry, Mahmoud Ramadan mohamed Elkazzaz 2020-05-07
An expanded access for compassionate use program to assess stem cells in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection stem cells alone GIOSTAR US Phase Not Applicable Not yet recruiting 0 Dr. Prabhat Soni 2020-05-06
Prehospital Intubation of COVID-19 Patient With Personal Protective Equipment Cardiac arrest, Coronavirus disease 19 infection Vie Scope laryngoscopy alone, endotracheal intubation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lazarski University Medical University of Bialystok, Poznan University of Medical Sciences, Wroclaw Medical University Poland 2020-03-20 2020-05-20 INT_EMS_PPE_1, NCT04365608 Phase Not Applicable Recruiting 2 2 Months 90 Lukasz Szarpak, PhD, Marek Dabrowski, PhD 2020-05-06
MYOCOVID: Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 (COVID-19) Cases Coronavirus disease 19 infection, Myocarditis CT scan alone, bacteriological test alone, immunological test alone, myocardial MRI alone, myocardial biopsy alone, parasitic tests alone, polymerase chain reaction alone, routine care alone, transthoracic echocardiography alone, viral test alone Centre Hospitalier Universitaire de Toulouse France 2020-04-15 2021-10-15 MYOCOVID, NCT04375748, RC31/20/0139 Phase Not Applicable Recruiting 1 18 Months 400 Audrey TOMASIK, Clément Delmas 2020-05-06
RECOVER: Trial to Promote Recovery From COVID-19 With Ivermectin or Endocrine Therapy Coronavirus disease 19 infection bicalutamide alone, standard of care alone Androgen receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sidney Kimmel Comprehensive Cancer Center US 2020-06-30 2021-06-30 COV2003, IRB00249425, NCT04374279, RECOVER Phase 2 Clinical Not yet recruiting 0 12 Months 60 Aliya Lalji, MD, Catherine H Marshall, MD/MPH, Jeffrey Rothstein, MD/PhD, Lindsey Hayes, MD/PhD, Samuel Denmeade, MD, Shawn Kwatra, MD, Vasan Yegnasubramanian, MD/PhD 2020-05-06
Early warning model and new biomarker of severe novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Anhui Provincial Hospital China 2020-01-10 2020-05-30 ChiCTR2000032460 Phase 0 Clinical No longer recruiting 1 4 Months 350 Meiqiao Chen, Wenting Li 2020-05-08
COVID19-FOIE National Observatory Brain disease, Coronavirus disease 19 infection, Diabetes mellitus, Hepatitis B virus infection, Hepatitis C virus infection, Hepatocellular carcinoma, Hypertension, Liver cirrhosis, Liver disease, Metabolic syndrome X, Obesity, Renal disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris Association Française pour l’Etude du Foie (AFEF), Societe Nationale Francaise de Gastroenterologie France 2020-05-05 2020-12-31 IRB00006477, NCT04375670 Phase Not Applicable Not yet recruiting 1 7 Months 1000 Nathalie Ganne-Carrié, MD-PhD 2020-05-08
Evaluation effect of indomethacin for Covid19 infection Coronavirus disease 19 infection, Viral pneumonia indomethacin (Aria Pharmaceutical Company) alone, usual treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Isfahan University of medical Sciences Iran 2020-05-08 IR.MUI.MED.REC.1399.045, IRCT20200427047215N1 Phase 2/Phase 3 Clinical Recruiting 1 60 Ali Darakhshandeh 2020-05-11
Effects of Mobile App in House Staff Health and Well-being During COVID-19 Pandemic Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Sleep disorder Calm Meditation App alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Arizona US 2020-05-01 2020-10-01 NCT04374786, TO BE DETERMINED Phase Not Applicable Not yet recruiting 0 5 Months 328 Kelley Saunders, Kelley T Saunders, MD, Mike Foley, MD, Rachael Smith, DO 2020-05-07
COR-CARDIO: Drug Safety and the Occurrence of Complications During Hospitalization in Patients With COVID-19 Cardiovascular disease, Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instytut Kardiologii Im Prymasa Tysiaclecia Poland 2020-05-05 2021-08-24 1860/2020, COR-CARDIO, NCT04374110 Phase Not Applicable Recruiting 2 15 Months 1000 Alekander Prejbisz, Aleksander Prejbisz, MD, PhD, Andrzej Januszewicz, MD, PhD, Piotr Dobrowolski, Piotr Dobrowolski, MD, PhD, Rafal Dabrowski, MD, PhD, Tomasz Hryniewiecki, MD, PhD 2020-05-07
Treatment of Angiotensin Peptide (1-7) for COVID-19 Coronavirus disease 19 infection angiotensin peptide (1-7) derived plasma alone, routine treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istanbul Bakirkoy Maternity and Children Diseases Hospital Turkey 2020-04-25 2020-09-30 KSSEAH--0059, NCT04375124 Phase 2 Clinical Recruiting 1 5 Months 20 Hasan Onal, Seda Yilmaz Semerci 2020-05-11
Investigating the efficacy of high dose of glucocorticoid in patients with moderate to severe pneumonia related to COVID-19 Coronavirus disease 19 infection, Viral pneumonia national guideline based routine treatment alone, methylprednisolone plus prednisolone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bagheiat-allah University of Medical Sciences Iran 2020-04-20 IR.BMSU.REC.1399.099, IRCT20080901001165N52 Phase 3 Clinical Recruiting 1 50 Ahmad Zarei, Behzad Einollahi, Gholamhosein Alishiri, Parisa Kianpour, Yunes Panahi 2020-05-08
Therapeutic Plasma Exchange Alone or in Combination With Ruxolitinib in COVID-19 Associated CRS Coronavirus disease 19 infection Therapeutic Plasma Exchange alone, ruxolitinib alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Prisma Health-Upstate US 2020-04-30 2021-04-30 NCT04374149, PHU COVID-19-001 Phase 2 Clinical Not yet recruiting 0 12 Months 20 Jan Kueber, RN, Julie Martin, DNP, W. Larry Gluck, MD 2020-05-08
Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19) Coronavirus disease 19 infection, Dysomia, Viral respiratory tract infection Nasal irrigation alone, NeilMed Sinus Rinse alone, NeilMed Sinus Rinse bottle alone, Olfactory retraining alone, budesonide plus budesonide (inhaled formulations), AstraZeneca Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lawson Health Research Institute Canada 2020-06-30 2021-12-31 ANOSMIA_COVID 19, NCT04374474 Phase 4 Clinical Not yet recruiting 2 18 Months 75 Brian Rotenberg, MD, Janet Knechtel, Khrystyna Ioanidi, MD, Leigh J Sowerby, Leigh J Sowerby, MD, Leigh Sowerby, MD, FRCSC, Sherry Paiva 2020-05-07
COVID-19 Serology Screening and Strict Protocol in the Endoscopy Unit Coronavirus disease 19 infection endoscopic examination alone, nucleic acid PCR testing alone, serological screening alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) INSTITUTO ECUATORIANO DE ENFERMEDADES DIGESTIVAS GASTROCLINICA S.A Ecuador 2020-04-20 2020-06-01 IECED-04-15-COVID, NCT04374123 Phase Not Applicable Recruiting 1 1 Month 80 Carlos A Robles-Medranda, MD, Roberto A Oleas, MD 2020-05-07
HEROS: COVID-19: Human Epidemiology and Response to SARS-CoV-2 Asthma, Coronavirus disease 19 infection Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) National Institute of Allergy and Infectious Diseases Rho Inc US 2020-05-01 2020-12-31 DAIT-COVID-19-001, HEROS, NCT04375761 Phase Not Applicable Recruiting 0 8 Months 8000 Alexandra Connolly, Amanda Cyrus, Andrew Liu, MD, Asel Baatyrbek, Christine C. Johnson, PhD, Christine M. Seroogy, MD, Daniel J. Jackson, MD, Dolores Santoyo, Edward Zoratti, MD, Elizabeth Tesson, George T. O'Connor, MD, MS, Gurjit K. Khurana Hershey, MD, PhD, Jen Smith, Kyle Koshalek, Kyra Jones, Leonard B. Bacharier, MD, Nicole Gonzalez, Pamela Groh, Pascuala Pinedo-Estrada, Rebecca Gruchalla, MD, Sherae Hereford, Stephen Teach, MD, Tiffany Ogundipe, Tina V. Hartert, MD, MPH, Zachary Flege 2020-05-07
COLVID-19: Colchicine in COVID-19: a Pilot Study Coronavirus disease 19 infection, Viral pneumonia colchicine alone, current care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universita Degli Studi Di Perugia Italy 2020-04-18 2020-10-31 2020-001475-33, COLVID-19, NCT04375202 Phase 2 Clinical Recruiting 2 6 Months 308 Carlo Scirè, Claudia Diana, Prof Roberto Gerli 2020-05-07
Clinical Trial to Evaluate the Efficacy and Safety of an Immunomodulatory Therapy for the Treatment of Patients With Moderate to Severe COVID-19 Infection Coronavirus disease 19 infection, Viral pneumonia metenkefalin acetate + tridecactide acetate (injectable, multiple sclerosis), Farmacija alone, standard of care treatment alone ACTH receptor agonist, Adrenocorticotrophic hormone ligand, Opioid growth factor receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bosnalijek Pharmaceutical & Chemical Industry Joint Stock Co Bosnia and Herzegovina 2020-05-01 2020-10-31 EN-COVCS-01, NCT04374032 Phase 2/Phase 3 Clinical Recruiting 1 6 Months 120 Jasna Dzananovic, MPharm, Rusmir Baljic, doc.dr.med 2020-05-08
COVHYP: Renin-Angiotensin-Aldosterone System Inhibitors, Hypertension, and COVID-19 Cancer, Chill, Congestive heart failure, Coronavirus disease 19 infection, Cough, Diabetes mellitus, Dyspnea, Heart disease, Hypertension, Lung malformation, Myalgia, Viral pneumonia chest CT-Scan alone, chest X-ray alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Versailles University Hospital France 2020-05-01 2020-07-01 COVHYP, NCT04374695, P20/11_COVHYP Phase Not Applicable Not yet recruiting 1 2 Months 700 Alisson BERTRAND, Alix PREVOT, Bernard LIVAREK, MD, Cécile LAUREANA, Floriane GILLES, MD, Guillaume ROGER, Jean-Baptiste AZOWA, Jean-François PROST, Jean-Louis GEORGES, MD, MPH, Jean-Paul BERESSI, MD, Joseph SABA, Joséphine SOLTANI, Maeva PASQUALINI, Marie DE TOURNEMIRE, Mehrsa KOUKABI FRADELIZZI, MD, Victorien MONGUILLON 2020-05-07
A Phase II, Open-Label, Randomized, Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications Coronavirus disease 19 infection, Respiratory distress syndrome, Sepsis convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India India 2020-05-09 2021-05-09 CTRI/2020/04/024915, MHC-COVID-19-CP, MHC-COVID-19-CP, Version 2.0, NCT04374487 Phase 2 Clinical Not yet recruiting 1 12 Months 100 Deven Juneja, DNB, Rahul Naithani, MD, DM, Rajesh Saxena, Rajesh Saxena, MBA, Sandeep Budhiraja, MRCP,FACP, Sangeeta Pathak, MBBS,Diploma 2020-05-07
Stem cell therapy in COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory tract infection, Viral pneumonia adipose and placenta-derived mesenchymal stem cell alone, common treatment alone Kermanshah University of Medical Sciences Iran 2020-05-09 IR.KUMS.REC.1399.065, IRCT20200418047121N2 Phase 1/Phase 2 Clinical Not yet recruiting 1 6 Farid Najafi, Kamran Mansouri 2020-05-07
Prevalence of SARS-CoV-2 in Conjunctival Swab Samples Among Patients With Conjunctivitis During the COVID-19 Pandemic Conjunctivitis, Coronavirus disease 19 infection, Keratoconjunctivitis, Ocular disease conjunctival swab sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Johns Hopkins University US 2020-05-31 2021-04-30 IRB00249598, NCT04374656 Phase Not Applicable Not yet recruiting 0 11 Months 50 Sezen Karakus, MD 2020-05-08
Monocytes and NK Cells Activity in Covid-19 Patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Università degli Studi dell'Insubria Italy 2020-04-27 2020-10-31 67/2020, NCT04375176 Phase Not Applicable Recruiting 1 6 Months 150 Andrea Vigezzi, MD, Andreina Baj, MD, Angelo Genoni, Dr, Annarosaria De Vito, PhD, Caterina Franchi, MD, Daniela Dalla Gasperina, Professor, Denisa Baci, PhD, Domenico Iovino, M.D., Domenico Iovino, MD, Elisa Monti, MD, Federica Masci, MD, Francesco Acquati, Professor, Giulio Carcano, Professor, Giuseppe Ietto, M.D., Giuseppe Ietto, MD, Lorenzo Mortara, Professor, Matteo Gallazzi, PhD, Valentina Iori, MD, Walter Ageno, Professor 2020-05-07
A Study of N-acetylcysteine in Patients With COVID-19 Infection Coronavirus disease 19 infection N-acetylcysteine alone, supportive care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Memorial Sloan-Kettering Cancer Center US 2020-05-01 2021-05-31 20-168, NCT04374461 Phase 2 Clinical Recruiting 0 13 Months 86 Jedd Wolchok, MD, PhD, Santosha Vardhana, MD, PhD 2020-05-11
Inhalable Sodium Bicarbonate: a Possible Adjuvant Treatment of Patients With Novel COVID-19 Coronavirus disease 19 infection, Viral pneumonia nebulizer alone, oseltamivir plus sodium bicarbonate Exo-alpha sialidase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mansoura University Egypt 2020-04-01 2020-06-01 NCT04374591, SODIUM BICARBONATE COVID-19 Phase 0 Clinical No longer recruiting 1 2 Months 20 Mohammed K Elbadrawy, PhD 2020-05-07
COVHECBEHO: COVID-19 Among Healthcare Workers in Belgian Hospitals Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sciensano Instituut Voor Tropische Geneeskunde Belgium 2020-04-22 2020-09-27 COVHECBEHO, NCT04373889, SCIENSANO Phase Not Applicable Recruiting 3 5 Months 800 Els Duysburgh, MD, MPH, PhD, Laure Mortgat, MD, MPH, Wesley Van Dessel 2020-05-11
Quality of Life and Physical Performance After Novel Coronavirus Infection (COVID-19) Coronavirus disease 19 infection education sessions alone, physical exercise alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kantonsspital Winterthur KSW Switzerland 2020-03-15 2021-08-31 2020_00899 / COV19_2020, NCT04375709 Phase Not Applicable Recruiting 1 17 Months 60 Cornel Sieber, Prof. MD, David Gisi, Giuseppe Mungo, MSc, Ines Unger, MSc Cand., Karrer Urs, PD MD, Markus Hofer, MD, Martina Betschart, PhD, Natalie Ott, MSc Cand., Spencer Rezek, MSc Cand., Swantje Beyer, MD 2020-05-08
LIFESAVER: Early transfusion of Convalescent Plasma in Elderly COVID-19 Patients to Prevent Disease Progression Coronavirus disease 19 infection COVID-19 Convalescent Plasma alone, standard therapy alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) Policlinico Universitario Agostino Gemelli Italy 2020-05-15 2021-06-30 3205, LIFESAVER, NCT04374526 Phase 2/Phase 3 Clinical Not yet recruiting 3 13 Months 182 Andrea Antinori, Prof., Antonella Cingolani, Jacopo Vecchiet, Prof., Luciana Teofili, Luciana Teofili, Prof., Maurizio Sanguinetti, Raffaele Landolfi, Prof. 2020-05-08
VADER: Verification of Alternative Do-it-yourself Equipment Respirators for the COVID-19 Personal Protective Equipment (PPE) Coronavirus disease 19 infection FFP2 alone, Face Fit test alone, Facial mask alone, PortaCount PRO+ 8038 alone, modified full-face snorkelling mask alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Clinique Universitaires Saint-Luc Belgium 2020-05-31 2020-05-31 2020/15AVR/226, NCT04375774, VADER Phase Not Applicable Recruiting 1 10 Guillaume Lemaire, MD, Marco Pettinger, MD 2020-05-11
LESSCOVID: London's Exogenous Surfactant Study for COVID19 Coronavirus disease 19 infection Bovine Lipid Extract Surfactant alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lawson Health Research Institute London Health Sciences Centre Research Inc Canada 2020-05-01 2021-07-01 9890, LESSCOVID, NCT04375735 Phase 1/Phase 2 Clinical Not yet recruiting 1 14 Months 20 Gordon Barkwell, MSc, Jim Lewis, MD, Tracey Bentall 2020-05-11
Effect of COVID-19 Pandemic on Pediatric Cancer Care Cancer, Coronavirus disease 19 infection south egypt cancer institute United Arab Emirates, Saudi Arabia, Egypt 2020-05-15 2021-05-15 COVID-19 AND PEDIATRIC CANCER, NCT04374838 Phase Not Applicable Not yet recruiting 3 12 Months 20 Mahmoud Motaz Elzembely 2020-05-07
COVID19-HOPE: Hydroxychloroquine in Combination With Azithromycin or Sirolimus for Treating COVID-19 Patients Coronavirus disease 19 infection Variable regimens including azithromycin , hydroxychloroquine , sirolimus mTOR inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) King Hussein Cancer Center Jordan 2020-05-01 2020-09-01 20 KHCC 74, COVID19-HOPE, NCT04374903 Phase 2 Clinical Not yet recruiting 1 4 Months 58 Abdelghani Tbakhi, PhD, Amal Al Omari, PhD, Anwar Alnassan, MD, Dalia Al Rimawi, MDS, Feras Hawari, MD, Hikmat Abdel-Razeq, MD, Iyad Ammouri, MD, Iyad Sultan, MD, Mayada Abu Shanap, MD, Mohammed Abufaraj, Prof., Nedal Al-Rawashdeh, MPH, Osama Abu Ata, MD, Rana Damsees, MPH, Rula Najjar, Pharm. D 2020-05-08
Risk of Venous Thromboembolism in Critically Ill Patients With Severe COVID-19 Coronavirus disease 19 infection, Deep vein thrombosis, Lung embolism, Viral pneumonia blood test alone, computed tomography angiography alone, duplex ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Vall D'Hebron Spain 2020-04-01 2020-05-01 NCT04374617, PR(AG)213/2020 Phase Not Applicable Completed 2 1 Month 230 Sergi Bellmunt, MD,PhD 2020-05-08
Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With CoronaVirus Induced Disease 2019 (COVID-19) and Pulmonary Distress Coronavirus disease 19 infection, Respiratory failure ibrutinib alone, standard care alone Btk tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AbbVie Inc Janssen Research & Development LLC US 2020-05-06 2020-08-27 M20-310, NCT04375397 Phase 2 Clinical Recruiting 0 3 Months 46 ABBVIE CALL CENTER, AbbVie Inc. 2020-05-08
ACT: Asymptomatic COVID-19 Trial Coronavirus disease 19 infection Hydroxychloroquine sulfate alone, Hydroxychloroquine sulfate plus azithromycin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rutgers University US 2020-05-05 2021-04-30 ACT, NCT04374552, PRO2020000872 Phase 2 Clinical Not yet recruiting 0 11 Months 140 Helaine Noveck, MPH, Jeffrey L Carson, MD 2020-05-08
Novel Agents for Treatment of High-risk COVID-19 Positive Patients Coronavirus disease 19 infection, Viral pneumonia camostat mesylate alone, hydroxychloroquine sulfate alone, Variable regimens including azithromycin , hydroxychloroquine sulfate , ivermectin Chloride channel modulator, Serine protease inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Kentucky US 2020-05-01 2021-05-31 MCC-20-COVID-01-PMC, NCT04374019 Phase 2 Clinical Recruiting 0 13 Months 240 Susanne Arnold, M.D., Susanne Arnold, MD 2020-05-08
Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia Coronavirus disease 19 infection, Viral pneumonia High-Titer Anti-SARS-CoV-2 (COVID 19) Convalescent Plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Virginia US 2020-05-05 2021-04-05 200114, NCT04374565 Phase 2 Clinical Recruiting 0 11 Months 29 Alex Kadl, MD, Amy Mathers, MD, Archana Thakur, PhD, Chelsea Sheppard, MD, James Gorham, MD, Jeffrey M. Sturek, MD, PhD, Jeffrey Sturek, Jeffrey Sturek, MD, PhD, Karen Ballen, MD, Kristen M Petros De Guex, MA, Lawrence G. Lum, MD, DSc, Melinda Poulter, PhD, Patrick Jackson, MD, Qin Liu, MD, PhD, Scott Heysell, MD, Taison Bell, MD, Tania Thomas, MD, MPH, William B Harrington, MPH 2020-05-11
COVIDANS Study: Testing for Dysautonomia in Patients Hospitalized for SARS-CoV-2 Infection (COVID-19) Autonomic nervous system disease, Coronavirus disease 19 infection ECG-Holter alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Saint Etienne France 2020-04-30 2020-10-31 2020-A01082-37, 20CH095, COVIDANS Study, NCT04374045 Phase Not Applicable Recruiting 1 6 Months 25 Béatrice DEYGAS, CRA, David CHARIER, MD, Frédéric ROCHE, MD-PhD, Isabelle COURT-FORTUNE, MD, Jerome MOREL, MD-PhD, Serge MOLLIEX, MD-PhD 2020-05-07
SARSCoV2 (COVID-19) Convalescent Plasma (CP) Expanded Access Protocol (EAP) Coronavirus disease 19 infection betacoronavirus (SARSCoV2) convalescent plasma (CP) alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AdventHealth US 1596191, NCT04374370 Phase Not Applicable Recruiting 0 Chris Ensor, PharmD, Eduardo Oliveira, MD 2020-05-07
Incidence and risk factors for acute kidney injury in COVID-19 Coronavirus disease 19 infection, Renal injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Klinikum der Albert-Ludwigs Universitaet Freiburg Germany 2020-03-01 2020-04-30 276/20, DRKS00021658 Phase Not Applicable Completed 1 2 Months 100 Johanna Schneider 2020-05-07
Efficacy and Safety of Early COVID-19 Convalescent Plasma in Patients Admitted for COVID-19 Infection Coronavirus disease 19 infection, Respiratory failure Anti-SARS-COV-2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Pontificia Universidad Catolica De Chile Arturo Lopez Perez Foundation Chile 2020-05-04 2021-12-31 200415015, NCT04375098 Phase 2 Clinical Recruiting 1 19 Months 30 Maria Elvira Balcells, MD 2020-05-07
A trial to evaluate TerraCoV2 for the treatment and prevention of Coronavirus disease 19 infection Coronavirus disease 19 infection TerraCoV2 vaccine (COVID-19), Noachis Terra alone COVID19 Spike glycoprotein modulator Oragenics Inc Noachis Terra Inc Phase Not Applicable Planned 0 2020-05-07
CovOM: Investigating the microorganisms found in the mouths of SARS-Cov-2 positive patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Ferrara Italy 2020-04-09 2020-10-01 COVOM, CovOM, ISRCTN87832712 Phase Not Applicable Not yet recruiting 3 5 Months 20 Prof Caselli 2020-05-07
Homoeopathy as adjuvant in management of coronavirus infection Coronavirus disease 19 infection homoeopathic medicines alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bajaj Auto Ltd India 2020-05-08 CTRI/2020/04/024925 Phase 2 Clinical Not yet recruiting 1 100 Dr Abhay S Talwalkar, Dr Anil Khurana, Dr Ayushi Shrikhande, Dr Govindarajan Sankaran 2020-05-07
COVID Immunity: The COVID Immunity Study Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Translational Genomics Research Institute US COVID Immunity Phase Not Applicable Planned 0 Dr. John Zaia 2020-05-08
A medical records based retrospective study: leukopenia is more common in asymptomatic patients less than 18 years old with novel coronavirus pneumonia (COVID-19) in convalescence Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Guizhou Provincial Staff Hospital, The Science and Technology Department of Guizhou Province China 2020-04-01 ChiCTR2000032458 Phase Not Applicable No longer recruiting 1 25 Wei Zhang 2020-05-08
A Clinical Trial to Ascertain the Effect of Homoeopathic Medicines in Prevention of Outbreak of Symptoms in Asymptomatic Coronavirus and Suspected Coronavirus Patients Coronavirus disease 19 infection homoeopathic medicine alone Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Naiminath Homoeopathic Medical College, Hospital and Research Centre India 2020-05-10 C-2020/05, CTRI/2020/04/024926 Phase 3 Clinical Not yet recruiting 1 100 Dr Ritu Gupta 2020-05-07
Diagnostic value of chest CT in outpatient for novel coronavirus pneumonia (COVID-19) compared to RT-PCR Coronavirus disease 19 infection, Viral pneumonia RT-PCR alone, chest-CT alone The Fifth People's Hospital of Ganzhou China 2020-01-01 2020-02-29 ChiCTR2000032574 Phase Not Applicable No longer recruiting 1 2 Months 248 Zhang Weiwei 2020-05-07
A randomized, double-blind, controlled trial for Bu-Fei-Huo-Xue Capsule in the treatment of novel coronavirus pneumonia (COVID-19) convalescence patient with ''Fei-Pi-Qi-Xu zhen'' Coronavirus disease 19 infection, Viral pneumonia Bufei Huoxue Capsule alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) State Key Laboratory Of Respiratory Diseases, The Fifth Affiliated Hospital of Guangzhou Medical University China 2020-05-02 2021-05-01 ChiCTR2000032573 Phase 0 Clinical Not yet recruiting 5 12 Months 120 Jian Wang, Nanshan Zhong 2020-05-07
Placental Mesenchymal Stem Cell Therapy for Acute Respiratory Distress Syndrome in Coronavirus Infection: A Phase I/II Clinical Trial Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia placental mesenchymal stem cell therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) National Institute for Medical Research Developement, Oghaf Organization and charity, Opal Parsian Company Iran 2020-03-20 IR.TUMS.VCR.REC.1399.009, IRCT20200413047063N1 Phase 1/Phase 2 Clinical Recruiting 2 20 Masoud Soleimani, Mohamad Azimi, Mohammad Alian Nejad, Mohammad Mokhber, Mohammad Reza Hashemian, Mohammad Vasei, Reza Malekzadeh, Sayed Mahdi Khamooshi 2020-05-07
Ozone Autohemotherapy in COVID-19 Coronavirus disease 19 infection conventional therapy alone, major autohemotherapy alone, ozone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Tabriz University of Medical Sciences Iran 2020-04-25 IR.TBZMED.REC.1399.022, IRCT20190618043923N4 Phase 2/Phase 3 Clinical Recruiting 1 20 Dawood Aghamohammadi, Mohammad Samiei 2020-05-07
PIONEER: A Randomized, Controlled Trial of Early Intervention in COVID-19: Favipiravir Versus Hydroxycholorquine and Azithromycin and Zinc versus Standard Care Coronavirus disease 19 infection, Influenza virus infection favipiravir alone, standard clinical care alone, Variable regimens including Plaquenil , azithromycin , zinc sulfate RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Chelsea & Westminster NHS Trust FUJIFILM Toyama Chemical Co Ltd, Imperial College London, Neat Id Foundation, Universitaire Ziekenhuizen Leuven UK 2020-05-01 2021-03-31 2020-001449-38, CW002, NCT04373733, PIONEER Phase 3 Clinical Not yet recruiting 2 11 Months 450 Bobby Mann, Pallav Shah, Research Delivery Operations Manager 2020-05-07
A Clinical Trial to study the effectiveness of Homoeopathy as an additional mode of treatment in combating Corona Virus infection Coronavirus disease 19 infection Homoeopathy (Arsenic Album, Bryonia Alba, Gelsemium, Antimonium Tartaricum, Crotalus Horridus) alone Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Central Council for Research in Homeopathy, Naiminath Homoeopathic Medical College, Hospital and Research Centre India 2020-05-05 C-2020/01, CTRI/2020/04/024905 Phase 3 Clinical Not yet recruiting 1 100 Dr Shaurabh Kumar 2020-05-07
PROTEGO: Prospective, Observational, Cohort Trial Evaluating Correlation of Clinical Findings, Symptoms And Disease Development Of German In- Or Outpatients Infected With SARS-CoV-2 - A CHIR-Net Student-Initiated German Medical Audit trial COVID-19 study (CHIR-Net SIGMA study group) Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Heidelberg Germany 2020-05-07 DRKS00021226, PROTEGO, S-215/2020, U1111-1250-1571 Phase Not Applicable Not yet recruiting 2 500 André Mihaljevic 2020-05-07
The effect of Intravenous immunoglobulin on COVID-19 infection Coronavirus disease 19 infection Intratect alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gonabad University of Medical Sciences Iran 2020-03-10 IR.GMU.REC.1399.009, IRCT20200418047116N1 Phase 2 Clinical Recruiting 1 20 Dr. Shahla Khosravan, Najme Davoodian, Negar Shafaei Bajestani 2020-05-06
ATTACC: Antithrombotic Therapy to Ameliorate Complications of COVID-19 Coronavirus disease 19 infection dalteparin sodium alone, enoxaparin sodium alone, tinzaparin sodium alone, unfractionated heparin alone Antithrombin III, Factor IIa antagonist, Factor Xa antagonist, Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Manitoba Hamilton Health Sciences Corp, Hopital Montfort, The University Health Network Canada 2020-05-31 2021-01-31 ATTACC, ATTACC, NCT04372589, OZM-113 Phase 2 Clinical Not yet recruiting 4 8 Months 3000 Jean-Philippe Galanaud, MD, Marc Carrier, MD, Patrick Lawler, MD, Peter Gross, MD, Ryan Zarychanski, MD 2020-05-06
C-reactive Protein Levels Among Individuals With COVID-19 Coronavirus disease 19 infection C-reactive protein test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Frederiksberg University Hospital Denmark 2020-05-04 2020-11-30 APPI2-CV-2020-02, NCT04373798 Phase Not Applicable Not yet recruiting 1 6 Months 3000 Henning Bliddal, DMSc 2020-05-06
An international, investigator-initiated clinical trial to evaluate the efficacy of Lambda in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection peginterferon lambda-1a, Eiger BioPharmaceuticals alone Interferon receptor modulator, Interleukin-29 ligand University of Toronto Eiger BioPharmaceuticals Inc Canada 2020-04-30 Phase Not Applicable Recruiting 1 2020-05-05
An international, investigator-initiated clinical trial to evaluate the efficacy of Lambda in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection peginterferon lambda-1a, Eiger BioPharmaceuticals alone Interferon receptor modulator, Interleukin-29 ligand Mount Sinai Hospital Eiger BioPharmaceuticals Inc US 2020-04-30 Phase Not Applicable Recruiting 0 2020-05-05
COVID-APE: Incidence of Acute Pulmonary Embolism in COVID-19 Patients on CT Angiography and Relationship to D-dimer Levels Coronavirus disease 19 infection, Lung embolism chest CT angiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-03-03 2020-05-01 7840, COVID-APE, NCT04373486 Phase Not Applicable Recruiting 1 1 Month 160 Aissam LABANI, MD, Catherine ROY, MD, Coralie PAUZET, MD, Françis SCHNEIDER, MD, PhD, François SEVERAC, MD, Ian LEONARD-LORANT, MD, Julie HELMS, MD, PhD, Mickaël OHANA, MD, PhD, Olivier COLLANGE, MD, PhD, Pascal BILBAULT, MD, PhD, Pierre LEYENDECKER, MD, Saïd CHAYER, PhD, HDR, Sébastien MOLIERE, MD, Xavier DELABRANCHE, MD, PhD 2020-05-06
An international, investigator-initiated clinical trial to evaluate the efficacy of Lambda in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection peginterferon lambda-1a, Eiger BioPharmaceuticals alone Interferon receptor modulator, Interleukin-29 ligand Soroka University Medical Center Eiger BioPharmaceuticals Inc Israel 2020-04-30 Phase Not Applicable Recruiting 1 2020-05-05
COVID-SHIELD: COVID-19 prophylaxis with hydroxychloroquine in Front-line Health and Allied-Health Care Workers Coronavirus disease 19 infection hdroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Walter and Eliza Hall Institute of Medical Research Australian Government Australia 2020-04-28 ACTRN12620000501943p, COVID-SHIELD, U1111-1250-4307 Phase 2/Phase 3 Clinical Not yet recruiting 15 2250 Arunee Wilson, Ms Liz Williams, Prof Marc Pellegrini 2020-05-06
VM Spacer plus MDI use in Outpatient ED - COVID-19 Pandemic Coronavirus disease 19 infection, Respiratory disorder Venturi Mask alone Hospital Kuala Lumpur Malaysia 2020-05-01 2021-04-30 54673, NMRR-20-840-54673 Phase Not Applicable Not yet recruiting 1 12 Months 103 Dr. Jacelyn Ong Jia Whey, KOH HOCK PENG 2020-05-06
Health Outcome Rheum Pt on SoC Dur Covid-19 Coronavirus disease 19 infection standard of care alone Selayang Hospital Malaysia 2020-05-04 2020-05-28 54731, NMRR-20-839-54731 Phase Not Applicable Status not specified 1 Dr Lim Shiau Li 2020-05-05
Survey of WHOQoL-Bref Scores Among Persons with Chronic Illness and Public During COVID-19 Pandemic in Malaysia Coronavirus disease 19 infection HOSPITAL TENGKU AMPUAN RAHIMAH KLANG Malaysia 2020-04-29 2020-12-31 54818, NMRR-20-838-54818 Phase Not Applicable Not yet recruiting 1 8 Months Dr. Jacelyn Ong Jia Whey, Dr. Muralitharan Perumal 2020-05-05
McMonty: A reusable personalised ventilation hood: a phase I safety study of a new device (McMonty) in patients with suspected or confirmed COVID-19 Coronavirus disease 19 infection McMonty hood device alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Western Health Sunshine Hospital, University of Melbourne Australia 2020-05-01 ACTRN12620000500954p, McMonty, U1111-1250-6657 Phase 1 Clinical Not yet recruiting 2 20 Dr Forbes McGain 2020-05-06
A study to assess the effectiveness of Ayurvedic formulation in addition to standard of care in COVID-19 positive patients in a tertiary hospital Coronavirus disease 19 infection Tinospora cordifolia stem kashaya alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medanta The Medicity, Ministry of Ayush Central Council for Research in Ayurvedic Sciences, Council of Scientific and Industrial Research (India) India 2020-04-28 CTRI/2020/04/024882 Phase 3 Clinical Not yet recruiting 1 60 DrSushila Kataria, Mr.Kuldeep K Chauhan 2020-05-06
The CERA Study: The COVID-19 Emergency Response Assessment Study: a survey of the psychological health of frontline doctors in the UK and Ireland during the coronavirus pandemic Coronavirus disease 19 infection North Bristol NHS Trust Royal College of Emergency Medicine Ireland, UK 2020-03-12 2020-10-01 ISRCTN10666798, The CERA Study, V5.0, IRAS 281944 Phase Not Applicable Recruiting 2 6 Months 7000 Dr Tom Roberts 2020-05-06
Treatment of COVID19 : A randomized controlled trial Coronavirus disease 19 infection, Viral pneumonia hydroxychloroquine alone, azithromycin plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ministry of Defence India 2020-05-11 CTRI/2020/04/024904 Phase 3 Clinical Not yet recruiting 6 300 AirCmde V K Sashindran, Ajay Kumar, Col Anurag Khera, Col Sanjeevan Sharma, Dheeraj Kumar, Kuldeep Ashta, Rajneesh Thakur, Snehangsh Dash 2020-05-07
HelloBetter Corona: Naturalistic evaluation of an Internet-based psychological training program for mental strain associated with the coronavirus / COVID-19 pandemic Coronavirus disease 19 infection, Psychiatric disorder HelloBetter Corona online training alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Friedrich-Alexander-Universitaet Erlangen-Nuernberg Germany 2020-05-06 172_20 B, DRKS00021588, HelloBetter Corona Phase Not Applicable Not yet recruiting 1 1000 Mathias Harrer 2020-05-05
SROCL: Stroke Rehabilitation Outcome During COVID-19 Lockdown Coronavirus disease 19 infection, Hemorrhagic stroke, Ischemic stroke physical activity engagement alone, rehabilitation therapy alone, upper limb usage alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Zurich Switzerland 2020-04-16 2021-04-30 BASEC-NR. 2020-00761, NCT04373109, SROCL Phase Not Applicable Recruiting 1 12 Months 70 Andreas R Luft, Prof, Janne M Veerbeek, PhD, Jeremia Held, Jeremia PO Held, PhD 2020-05-07
Characteristics of seriously ill COVID-19 patients admitted to a tertiary care center Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences India 2020-05-08 CTRI/2020/04/024914 Phase Not Applicable Not yet recruiting 1 60 Dr Sulagna Bhattacharjee 2020-05-11
Impact of Quarantine on Quality of Life Among Persons Screened for COVID-19 in Malaysia Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HOSPITAL TENGKU AMPUAN RAHIMAH KLANG Malaysia 2020-04-30 2020-07-29 54817, NMRR-20-837-54817 Phase Not Applicable Not yet recruiting 1 3 Months Dr Yap Soong Yiing, Dr. Muralitharan Perumal 2020-05-11
Clinical research on safety and efficacy of ZingiVir-H as an add on therapy in COVID-19 patients Coronavirus disease 19 infection ZingiVir-H alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Pankajakasthuri Ayurveda Medical College and Post Graduate Center India 2020-04-29 CTRI/2020/04/024883 Phase 4 Clinical Recruiting 1 112 Dr Shan Sasidharan, DrJHareendran Nair 2020-05-05
NPATCM Coronavirus disease 19 infection Decoction of Traditional Chinese Medicines therapy alone National Institutes of Health Malaysia Malaysia 2020-04-28 2022-04-01 LFF0015 54738, NMRR-20-833-54738 Phase Not Applicable Status not specified 1 23 Months Dr lem fui fui 2020-05-11
PRIEST: Evaluation of COVID-19 assessment in emergency departments and ambulance services Coronavirus disease 19 infection, Respiratory tract infection Emergency triage alone Sheffield Teaching Hospitals NHS Foundation Trust NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) UK 2012-10-01 2020-07-31 CPMS 12725, IRAS 101138, ISRCTN28342533, PRIEST Phase Not Applicable Recruiting 64 94 Months Prof Goodacre 2020-05-05
GPWTMCVD19 Coronavirus disease 19 infection personal protective equipment alone HOSPITAL SERI MANJUNG Malaysia 2020-05-01 2020-12-31 54819, NMRR-20-832-54819 Phase Not Applicable Recruiting 1 8 Months Gobi Hariyanayagam a/l Gunasekaran 2020-05-11
Clinical and immunological predictors of SARS-CoV-2 infection and COVID-19 diseases in patients with renal diseases and healthy persons Coronavirus disease 19 infection, Renal disease Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nierenzentrum Heidelberg Nierenzentrum e.V. Germany 2020-04-06 DRKS00021297, S-224/2020 Phase Not Applicable Recruiting 1 100 Claudia Sommerer 2020-05-05
Antiviral Therapy and Baricitinib for the Treatment of Patients With Moderate or Severe COVID-19 Coronavirus disease 19 infection, Viral pneumonia Variable regimens including baricitinib , hydroxychloroquine , lopinavir + ritonavir , remdesivir Coronavirus non structural protein 8 modulator, HIV protease inhibitor, Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Southern California National Cancer Institute US 2020-04-24 2022-04-24 0S-20-3, NCI-2020-02685, NCT04373044, P30CA014089 Phase 2 Clinical Not yet recruiting 0 24 Months 59 Heinz-Josef Lenz, MD, Tali Homsey, BA 2020-05-07
The Prophylactic Effect Of Hydroxychloroquine On Novel Corona Virus Coronavirus disease 19 infection hydroxychloroquine, Tehran Darou, Iran alone, routine care alone Arak University of Medical Sciences and Health Services Iran 2020-04-13 IR.ARAKMU.REC.1398.345, IRCT20151222025660N2 Phase 3 Clinical Recruiting 2 140 Dr Alirza Kamali, Dr. Ramin Parvizrad, Dr.Ramin Parvizrad 2020-05-06
Survive and Thrive: exploring the wellbeing of doctors in a post-COVID-19 era Anxiety disorder, Coronavirus disease 19 infection, Depression University Of Southampton Health Education England UK 2020-01-21 2021-12-31 55747, ISRCTN20867558 Phase Not Applicable Recruiting 1 23 Months 350 Dr Simons 2020-05-06
Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Semmelweis University Hungary 2020-04-16 2020-08-31 57/2020., NCT04372576 Phase Not Applicable Recruiting 1 4 Months 30 Bence Mogyoródi, MD, Zsolt Iványi 2020-05-06
PredictCovidT: Blood Biomarkers as Predictors of COVID-19 Disease Progression in Recently Infected Kidney Transplant Patients Coronavirus disease 19 infection blood sample alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Nice France 2020-04-22 2020-10-22 20-PP-09, NCT04369456, PredictCovidT Phase Not Applicable Recruiting 7 6 Months 115 Alexandre HERTIG, Antoine SICARD, Barbara SEITZ-POLSKI, Christophe MARIAT, Dany ANGLICHEAU, Elisa DEMONCHY, Jean DELLAMONICA, Moglie Le Quintrec, Olivier THAUNAT, Renaud SNANOUDJ, Valerie MOAL, alexandre HERTIG, christophe MARIAT, cynthia CAILLON, sophie Caillard Ohlmann, valerie MOAL 2020-05-06
INVICTUS: Weaning From Mechanical Ventilation for ARDS CovId-19 Patients Guided by Combined Thoracic Ultrasound Coronavirus disease 19 infection, Respiratory distress syndrome combined thoracic ultrasound-based mechanical ventilation weaning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-04-22 2020-09-22 2020-A00916-33, INVICTUS, NCT04372680, RC31/20/0138 Phase Not Applicable Recruiting 2 5 Months 200 AUDREY BELLOC, Beatrice RIU-POULENC, PH, Béatrice RIU-POULENC, NADERA AINAOUI, PHD, Paul BOURZEIX, Philippe VIGNON, PU PH, Stein SILVA, PU PH 2020-05-06
Efficacy of solnatide to treat pulmonary permeability oedema in SARS-Cov-2 positive patients with moderate-to-severe ARDS Coronavirus disease 19 infection, Pulmonary edema, Respiratory distress syndrome solnatide (liquid aerosol inhalation, pulmonary edema), Apeptico/ Mediolanum alone Sodium channel stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical University of Vienna Apeptico Forschung und Entwicklung GmbH Austria 2020-04-11 2020-001244-26, COV-2-SOLNATIDE-20 Phase 2 Clinical Recruiting 1 40 Markus Zeitlinger 2020-05-07
Effect of Atorvastatin in Treatment of COVID-19 Infection Coronavirus disease 19 infection atorvastatin alone, standard treatment alone HMG CoA reductase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Islamic Azad University Iran 2020-04-13 IR.IAU.PS.REC.1399.002, IRCT20200413047062N1 Phase 3 Clinical Recruiting 1 76 Farshad Hashemian, Hamidreza Moezi, Keyhan Mohammadi, Maysa Ghayyem 2020-05-06
Understanding Immunity to SARS-CoV-2, the Coronavirus Causing COVID-19 Coronavirus disease 19 infection, Viral pneumonia Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stanford University National Institute of Allergy and Infectious Diseases US 2020-04-08 2022-04-30 2U19AI057229, IRB-55689, NCT04373148 Phase Not Applicable Recruiting 0 24 Months 1000 Hena Din, Kari Nadeau, MD, PhD 2020-05-06
Analysis of clinical features of novel coronavirus pneumonia (COVID-19): a medical records based study Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Xiangya Hospital Of Central South University China 2020-03-23 2021-03-23 ChiCTR2000032476 Phase Not Applicable Recruiting 1 12 Months 500 Pinhua Pan 2020-05-06
A medical records based retrospective study for effect of applying individualized Chinese herbal medicine in treatment of patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Chinese herbal medicine alone The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Science & Technology Department of Sichuan Province China 2020-05-06 2020-07-31 ChiCTR2000032461, ChiMCTR2000003266 Phase Not Applicable Not yet recruiting 3 2 Months 500 Chunguang Xie, Huizhen Chen 2020-05-06
Assessment of effect of levamisole on pneumonia caused by COVID-19 Coronavirus disease 19 infection, Viral pneumonia levamisole alone, symptomatic therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Shiraz University of Medical Sciences Iran 2020-05-04 IR.SUMS.REC.1399.178, IRCT20131215015805N2 Phase 4 Clinical Recruiting 1 50 Dr Mohsen Moghaddami, Dr Payam Peymani, Dr mohsen moghadami, Kamran Bagheri Lankarani 2020-05-06
MeHeS-STAFF Coronavirus disease 19 infection Hospital Tunku Azizah Malaysia 2020-05-01 2020-10-31 54721, NMRR-20-852-54721 Phase Not Applicable Not yet recruiting 1 6 Months Dr LUI SZE CHIANG 2020-05-06
SOAP: School opening in Norway during the COVID-19 pandemic Coronavirus disease 19 infection school opening program alone Norwegian Institute of Public Health Norway 2020-03-18 2020-09-30 ISRCTN44152751, SOAP Phase Not Applicable Not yet recruiting 1 6 Months 125 Prof Atle Fretheim 2020-05-06
ACICOVID: Cardiac Arrest Incidence and Outcome Among Patients With COVID-19 in French ICUs Cardiac arrest, Coronavirus disease 19 infection, Viral pneumonia cardiopulmonary resuscitation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer France 2020-05-31 2020-12-31 2020-CHITS-004, ACICOVID, NCT04373759 Phase Not Applicable Not yet recruiting 35 7 Months 100 Alain Gaffinel, Arnaud Galbois, Arnaud Galbois, MD, Asmaa JOBIC, Benjamin Sztrymf, Benjamin Sztrymf, MD, Camille Foucault, Camille Foucault, MD, Cedric Bruel, Cedric Bruel, MD, Cedric Daubin, Cedric Daubin, MD, Charles Damoisel, MD, Christophe Vinsonneau, Christophe Vinsonneau, MD, Clement Suply, Coralie Gernez, Damien Roux, MD, Damien Vimpere, David Schnell, David Schnell, MD, Didier Thevenin, Didier Thevenin, MD, Dorothee Carpentier, Dorothee Carpentier, MD, Elena Skripkina, Elena Skripkina, MD, Gaetan Plantefeve, Gaetan Plantefeve, MD, Guillaume Geri, Guillaume Geri, MD, Jean-Philippe Suppini, Jean-Pierre Quenot, Jean-Pierre Quenot, MD, Jennifer Brunet, Jobic Asmaa, Jonathan Chelly, Jonathan Chelly, MD, Julie Noublanche, Julien Fournier, Karim Chaoui, MD, Laurent Guérin, Lionel Lamhaut, Ly Van Vong, Ly Van Vong, MD, Marie-Anne Mélone, MD, Marine Paul, Marine Paul, MD, Marjorie Fleury, Maxime Leloup, Maxime Leloup, MD, Michel Kaidomar, Natacha Kapandji, Natacha Kapandji, MD, Nicolas Deye, Nicolas Deye, MD, Nicolas Pichon, Nicolas Pichon, MD, Nicolas Terzi, Nicolas Terzi, MD, Riad Chelha, MD, Richard Descamps, MD, Romain Persichini, Romain Persichini, MD, Saad Nseir, Saad Nseir, MD, Sandie Mazerand, Santiago Freita Ramos, Santiago Freita Ramos, MD, Santiago Picos, Sebastien Ehrminger, MD, Sebastien Jochmans, Sebastien Jochmans, MD, Tai Pham, Thomas Hullin, Thomas Hullin, MD, Toufik Kamel, Toufik Kamel, MD, Vivien Hong Tuan Ha, Vivien Hong Tuan Ha, MD 2020-05-07
Screening of Cancer Patients to Assess Impact of COVID-19 Coronavirus disease 19 infection nasopharyngeal (NP) swab alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University Health Network Canada 2020-05-04 2020-12-04 CAPCR 20-5337, NCT04373005, U-DEPLOY: RESPONSE Phase Not Applicable Not yet recruiting 1 7 Months 1000 Stephanie Lheureux, M.D. 2020-05-06
HARMONICOV: Human Ab Response and immunomonitoring of COVID-19 Patients Coronavirus disease 19 infection, Respiratory distress syndrome blood sampling alone, immunomonitoring alone, saliva collection alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rennes University Hospital France 2020-05-15 2020-11-15 2020-A01100-39, 35RC20_9795_HARMONICOV, HARMONICOV, NCT04373200 Phase Not Applicable Not yet recruiting 1 6 Months 75 Alexandre MANSOUR, MD, Florian REIZINE, MD, Isabelle GOUIN, MD, Jean-Marc TADIE, MD, PhD, Karin TARTE, MD, PhD, Mathieu LESOUHAITIER, MD, Michel COGNE, MD, PhD, Mikaël ROUSSEL, MD 2020-05-07
COVENTRY: One-Year Quality of Life and Functional Prognosis of COVID-19 Patients in Post-ICU Setting Coronavirus disease 19 infection lung ultrasound alone, muscle ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Groupe Hospitalier Paris Saint-Joseph Hôpital Forcilles France 2020-04-16 2021-09-16 COVENTRY, COVENTRY, NCT04373811 Phase Not Applicable Recruiting 1 17 Months 50 Andreia LOPES, PT, Aymeric LE NEINDRE, PT, PhD, Carlos DIAZ, PT, MSc, Gérald CHOUKROUN, MD, Hélène BEAUSSIER, PharmD, PhD, Joséphine COTTIAS, PT, Nesrine BEN NASR, PharmD, PhD, Pascal MEYER, MD 2020-05-06
BRACE-CORONA: Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Patients With COVID19 Coronavirus disease 19 infection Suspension of Angiotensin Receptor Blockers and Angiotensin-converting Enzymes alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto D'Or de Pesquisa Brazilian Clinical Research Institute Brazil 2020-04-06 2020-12-01 BRACE-CORONA, NCT04364893, PRJ_2003 Phase Not Applicable Recruiting 1 7 Months 500 Renato D. Lopes, MD, PhD 2020-05-11
Study for using sulfate in the prevention and control of novel coronavirus pneumonia (COVID-19) in high and low prevalence communities Coronavirus disease 19 infection, Viral pneumonia hydroxychloroquine sulfate alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Shanghai Public Health Clinical Center China 2020-03-01 2020-09-30 ChiCTR2000032487 Phase 4 Clinical Not yet recruiting 1 7 Months 2000 Lu Xia, Shuihua Lu 2020-05-06
CRC-COVID: COVID-19 Infection: Exploration of Respiratory Control Center Abnormalities Coronavirus disease 19 infection 14.3 and 12.7% FIO2, hypercapnia 7% CO2, inspiratory mechanical constraint alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris 2020-04-27 2021-11-27 APHP200476, CRC-COVID, NCT04363749 Phase Not Applicable Not yet recruiting 0 19 Months 30 Thomas Similowski, MD, PhD 2020-05-08
Comparison of three methods of treatment in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without coronavirus positive test (COVID-19) Coronavirus disease 19 infection, Vitamin C deficiency, Vitamin D deficiency routine treatment alone, vitamin C supplement alone, vitamin D supplement alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sabzevar University of Medical Sciences Iran 2020-04-20 IR.MEDSAB.REC.1399.015, IRCT20140305016852N4 Phase 2/Phase 3 Clinical Recruiting 1 30 Ebrahim Shirzade, Fereshteh Ghorat, Somayyeh Nayyeri 2020-05-06
COVIDOP-DVT: Incidence of Deep Vein Thrombosis at Doppler Echo in Covid-19 Patients With SARS-Cov-2 Pneumopathy Hospitalized in ICU Coronavirus disease 19 infection, Deep vein thrombosis, Viral pneumonia Doppler Echo alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Versailles University Hospital France 2020-04-27 2020-10-30 COVIDOP-DVT, NCT04363528, P20/08 Phase Not Applicable Not yet recruiting 1 6 Months 50 Aurelien Maurizot 2020-05-07
KAPFM Coronavirus disease 19 infection respiratory protective device alone HOSPITAL SERI MANJUNG Malaysia 2020-05-04 2020-12-01 54775, NMRR-20-850-54775 Phase Not Applicable Status not specified 1 6 Months Gobi Hariyanayagam a/l Gunasekaran 2020-05-06
Clinical study on Dabur Chyawanprash as a preventive remedy in pandemic of Covid-19 Coronavirus disease 19 infection Chyawanprash alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Dabur India Ltd India 2020-05-15 CTRI/2020/05/024981, DCP-CVD-19/2020/01 Phase Not Applicable Not yet recruiting 5 600 Dr Arun Gupta, Dr Pawankumar Godatwar, Dr Pranita Deshmukh, Dr Raman Ghungralekar, Dr Sanjay Tamoli, Dr Shailesh Deshpande, Dr Vaishali Deshpande 2020-05-07
COVI-DOSE: Weight-Adjusted versus Fixed Low-Doses of Low Molecular Weight Heparin For Venous Thromboembolism Prevention in COVID-19 Coronavirus disease 19 infection, Thromboembolism, Viral pneumonia Variable regimens including dalteparin sodium , enoxaparin sodium , nadroparin calcium , tinzaparin sodium Antithrombin III, Factor IIa antagonist, Factor Xa antagonist, Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France Ministry of Health, France France 2020-05-31 2020-10-31 2020-001709-21, COVI-DOSE, NCT04373707 Phase 4 Clinical Not yet recruiting 14 5 Months 602 Alessandra Bura-Rivière, Amer Hamadé, Béatrice Terriat, Dominique Stephan, El Mehdi Siaghy, Francis Couturaud, Gabrielle Sarlon-Bartoli, Isabelle Quéré, Julien Bertrand, Nicolas Meneveau, Olivier Sanchez, Patricia Costa, Patrick Mismetti, Saïda Khaled-Jousselin, Res Proj Man, Simon Soudet, Stéphane Zuily, Stéphane Zuily, MD, PhD, Wael Younès, Yohann Bernard, Res Proj Man 2020-05-06
Homoeopathy as adjuvant in management of Covid-19 infection Coronavirus disease 19 infection, Viral pneumonia Homoeopathic medicines alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Naiminath Homoeopathic Medical College, Hospital and Research Centre India 2020-05-10 CTRI/2020/05/024969 Phase 2/Phase 3 Clinical Not yet recruiting 1 100 Dr Anil Khurana, Dr Debadatta Nayak, Prof Dr Pradeep Kumar Gupta 2020-05-07
PROVID-19: Impact of Prone Position in Patients Under Spontaneous Breathing on Intubation or Non-invasive Ventilation or Death Incidence During COVID-19 Acute Respiratory Distress Coronavirus disease 19 infection conventional positioning alone, prone position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Régional d'Orléans France 2020-05-31 2022-05-31 CHRO-2020-09, NCT04363463, PROVID-19 Phase Not Applicable Not yet recruiting 14 24 Months 400 Amanda LOPES, Dr, Aurélie DESPUJOLS, Aymeric SEVE, Dr, Elodie POUGOUE TOUKO, Elsa NYAMANKOLLY, Elsa NYAMANKOLLY, Dr, François MAILLOT, Pr, Jean-François GAUTIER, Pr, Laurent PLANTIER, Pr, Louis BERNARD, Pr, Léa COLOMBAIN, Dr, MARINE MORIER, Mai-Anh NAY, Dr, Marine MORIER, Dr, Nicolas BIZIEN, Dr, Pierre SELLIER, Pr, Sylvie DRUELLE, Sylvie DRUELLE, Dr, Xavier POUGET-ABADIE, Xavier POUGET-ABADIE, Dr 2020-05-07
COVID'HEMOS: Study of the Vascular Compartment and Hypercoagulability During Coronavirus Infection COVID-19 Coronavirus disease 19 infection blood sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Boisguillaume France 2020-04-09 2020-07-31 2020/0104/OB, COVID'HEMOS, NCT04367662 Phase Not Applicable Recruiting 1 3 Months 100 Francois CARON, Pr, Julien BLOT, Manuel ETIENNE, Pr, Paul BILLOIR, Pharmacist, Paul BILLOIR, pharmacist, Véronique LE CAM, MD 2020-05-06
COVID-19 social study: the effects of quarantine on mental health Coronavirus disease 19 infection, Psychiatric disorder Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University College London Nuffield Foundation UK 2020-03-23 2020-12-31 12467/005, ISRCTN97041334 Phase Not Applicable Recruiting 1 9 Months 1000000 Ms Vas James 2020-05-06
Developing and validating of clinical prediction model for novel coronavirus pneumonia (COVID-19) patients progressing to critical type, acute respiratory distress syndrome and death: a medical records based study Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tongji Medical College China 2020-05-01 2021-04-30 ChiCTR2000032527 Phase Not Applicable Not yet recruiting 1 12 Months 8500 Shusheng Li, Yi Bian 2020-05-06
Enhanced Hood PPE to Minimize COVID-19 Transmission to Front-line Health Care Workers Coronavirus disease 19 infection modified IPAC-UHN PPE alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) The University Health Network Canada 2020-05-07 2020-08-31 20-5448, NCT04373096 Phase Not Applicable Not yet recruiting 1 3 Months 42 Anahi Perlas, MD,FRCPC, Mehdi Soheili, Rongyu Jin 2020-05-06
MUM: Global Mental Health of Urban Mothers Anxiety disorder, Coronavirus disease 19 infection, Depression, Post traumatic stress disorder Web-based psychosocial peer-to-peer support alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Karolinska Institutet Swiss National Science Foundation Sweden, China, Hong Kong 2020-06-30 2023-06-30 MUM, NCT04363177, P2SKP3_187728 Phase Not Applicable Not yet recruiting 3 36 Months 300 Ewa Andersson, PhD, Hsuan-Ying Huang, PhD, Liping Zhu, PhD 2020-05-07
A clinical study of anti-SARS-CoV-2 antibodies for the treatment of COVID-19 Coronavirus disease 19 infection anti-SARS-CoV-2 antibodies (COVID-19), AbCellera/Eli Lilly alone AbCellera Biologics Inc 2020-07-31 Phase Not Applicable Planned 0 2020-05-05
Effect of curcumin-piperine supplementation on disease duration, severity and clinical signs, and inflammatory factors in patients with coronavirus (COVID-19): A randomized, double-blind, placebo-controlled clinical trial study Coronavirus disease 19 infection curcumin capsules plus piperine capsules Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Isfahan University of medical Sciences Iran 2020-05-04 IR.MUI.MED.REC.1399.049, IRCT20121216011763N46 Phase Not Applicable Recruiting 1 100 Gholamreza Askari, Shaghayegh Haghjou 2020-05-06
Application of pulmonary rehabilitation exercise in the treatment of novel coronavirus pneumonia (COVID-19) patients during convalescence period Coronavirus disease 19 infection, Viral pneumonia pulmonary rehabilitation exercise alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Huazhong University of Science and Technology Beijing Chao-Yang Hospital China 2020-05-01 2020-05-31 ChiCTR2000032457 Phase Not Applicable Not yet recruiting 1 1 Month 60 Wang Feng, Zhang Jianchu 2020-05-06
PLASCOSSA: Efficacy of Convalescent Plasma Therapy in the Early Care of COVID-19 Patients Coronavirus disease 19 infection SARS-CoV-2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Direction Centrale du Service de Sante des Armees University Hospital, Grenoble France 2020-05-31 2021-05-31 2020-A01166-33, NCT04372979, PLASCOSSA Phase 3 Clinical Not yet recruiting 4 12 Months 80 Catherine VERRET, Christophe MARTINAUD, Christophe MARTINAUD, PU PH, Christophe RENARD, Cécile FICKO, Damien RICARD, Fabien DUTASTA, Hervé FOEHRENBACH, Hélène SAVINI, Jean-Luc BOSSON, Jean-Paul HYRIEN, Katia AVMART, Marc ALETTI 2020-05-06
Effects of convalescent plasma in COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome COVID-19 convalescent plasma alone, standard national guideline treatment alone Oroumia University of Medical Sciences Urmia University of Medical Sciences Iran 2020-05-04 IR.UMSU.REC.1399.030, IRCT20200501047258N1 Phase 2/Phase 3 Clinical Recruiting 1 120 Iraj Mohebbi, Rahim Asgari, Rahim Asghari 2020-05-06
Clinical trial on Immunity and antiviral for quarantine patients of COVID-19 Coronavirus disease 19 infection, Immune disorder MyVir alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) MiLab LifeSciences (P) Ltd India 2020-05-11 CT/MiLab/MyVir/2020, CTRI/2020/05/024967 Phase 4 Clinical Not yet recruiting 1 30 Dr CR Jayanthi, MrLAKSHMANA PERUMAL SPT 2020-05-07
A Randomized Controlled Trial for the Effects of Low-Oxygen Consumption Instruction on the Prognosis of Patients with Novel Coronavirus Pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia low oxygen consumption alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Shanghai Public Health Clinical Center China 2020-03-01 2020-05-01 ChiCTR2000032456 Phase Not Applicable Completed 1 2 Months 100 Shuihua Lu, Yang Yang 2020-05-06
TREAT NOW: Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19 Coronavirus disease 19 infection, Respiratory tract infection hydroxychloroquine alone, lopinavir + ritonavir alone HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Vanderbilt University Medical Center, US AbbVie Inc US 2020-05-01 2021-05-01 200827, NCT04372628, TREAT NOW Phase 2 Clinical Not yet recruiting 0 12 Months 900 Adit A Ginde, MD, Lani L. Finck, Margaret A. Hays, Margaret Hays, Nathan I. Shapiro, M.D., Nathan L Shapiro, MD, Sharon Hayes, RN, Todd Rice, MD, Todd W. Rice, M.D., Todd W. Rice, MD 2020-05-06
The use of topical Povidone Iodine (PVP-I) oropharyngeal and intranasal application during the current coronavirus pandemic as a potential measure to reduce viral transmission Coronavirus disease 19 infection Povidone Iodine alone, standard oral antiviral therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) WIN MEDICARE PVTLTD Drugs Control Administration India 2020-05-05 CTRI/2020/05/024962 Phase Not Applicable Not yet recruiting 1 96 Dr Sumita Shankar 2020-05-07
COST ACTION: Study for the Evaluation of Specific Antibodies Anti Covid-19 Linked to Covid-19 Infection, Symptoms and Genetic Expression of ACE2 Polymorphisms in Patients Coronavirus disease 19 infection BioMedomics COVID-19 IgM-IgG Rapid Test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ospedale San Paolo Italy 2020-03-30 2020-09-30 2020/ST/057, COST ACTION, NCT04367402 Phase Not Applicable Recruiting 1 6 Months 600 Stefano Centanni, Full Professor 2020-05-06
Home Pulse Oximeter Use in Patients With COVID-19 Coronavirus disease 19 infection pulse oximetry alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Swedish Hospital US 2020-03-20 2020-04-22 2020032301, NCT04373161 Phase Not Applicable Completed 0 1 Month 209 Kaushal Majmudar, Sonia Shah, DO 2020-05-07
MIA-COVID-19: Minimal Invasive Autopsies to Investigate Changes in Deceased COVID-19 Patients Coronavirus disease 19 infection CT-scan alone Jessa Hospital Antwerp University Hospital, Universiteit Hasselt Belgium 2020-04-14 2020-12-31 JESSAH_COVID-19_MIA, MIA-COVID-19, NCT04366882 Phase Not Applicable Recruiting 1 8 Months 45 Jan Vanrusselt, MD, Janneke Cox, MD, PhD 2020-05-06
A study for the mental health status of novel coronavirus pneumonia (COVID-19) convalescent patients and first-line medical staff and Isolate residents and Hospital staffand the intervention strategy of psychological crisis in Ningxia Coronavirus disease 19 infection psychological crisis intervention alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ningxia Medical University China 2020-04-28 2021-12-31 ChiCTR2000032455 Phase 0 Clinical Recruiting 1 20 Months 140 Jiang Hong, Ma Xin-rong 2020-05-06
US3R: Health Care Use During the COVID-19 Crisis Coronavirus disease 19 infection online questionnaire alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universite Catholique de Louvain Belgium 2020-05-01 2021-10-31 NCT04372030, US3R, US3R Phase Not Applicable Not yet recruiting 1 18 Months 10000 Dominique Vanpee, MD, Sandy Tubeuf, PhD 2020-05-06
RFCIM: RFCIM Coronavirus disease 19 infection Government of Malaysia Malaysia 2020-05-01 2022-04-30 54832, NMRR-20-861-54832, RFCIM Phase Not Applicable Status not specified 1 24 Months Associate Prof Dr Awang bulgiba awang mahmud, Devi Peramalah 2020-05-08
Economic burden of COVID-19 in Malaysia Coronavirus disease 19 infection Government of Malaysia Malaysia 2020-05-04 2022-12-19 54823, NMRR-20-865-54823 Phase Not Applicable Not yet recruiting 1 31 Months Dr Amirah binti Azzeri, Dr Maznah Dahlui 2020-05-07
Clinical characteristics of renal patients with COVID-19 infection Coronavirus disease 19 infection, Renal failure Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nierenzentrum Heidelberg Germany 2020-04-06 DRKS00021295, S-223/202 Phase Not Applicable Recruiting 1 100 Claudia Sommerer 2020-05-07
A multicenter, randomized, open comparative clinical trial of the drug Favipiravir in patients hospitalized with COVID-19 Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor ChemRar High Tech Center, Russian Direct Investment Fund Russian Federation 2020-04-28 Phase 2 Clinical Recruiting 3 330 2020-05-05
Convalescent Plasma for the Treatment of Patients With COVID-19 Coronavirus disease 19 infection, Dyspnea, Respiratory failure COVID-19 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Colorado, Denver, US US 20-0990, NCT04372368 Phase Not Applicable Recruiting 0 John D Beckham, MD 2020-05-06
A clinical trial of XRx-101 for prevention of acute kidney injury due to coronavirus/COVID-19 infection Coronavirus disease 19 infection, Renal injury oxypurinol (acute kidney injury/lung injury/COVID-19), XORTX Therapeutics alone Xanthine oxidase inhibitor XORTX Therapeutics Inc Phase Not Applicable Planned 0 2020-05-05
A clinical trial of Wyss-designed swabs for COVID-19 Coronavirus disease 19 infection Wyss-designed swabs alone Wyss Institute for Biologically Inspired Engineering US Phase Not Applicable Planned 0 2020-05-08
Convalescent Plasma to Limit SARS-CoV-2 Associated Complications Coronavirus disease 19 infection SARS-CoV-2 convalescent plasma (HCIP) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Johns Hopkins University Bloomberg Philanthropies, University of Maryland US 2020-05-11 2023-01-31 CSSC-004, IRB00247590, NCT04373460 Phase 2 Clinical Not yet recruiting 0 32 Months 1344 David J Sullivan, MD, David Sullivan, MD 2020-05-06
SQuISH-COVID: SQuISH-COVID: A Pilot Study Coronavirus disease 19 infection, Sepsis SeptiScan System alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cytovale Inc Biomedical Advanced Research and Development Authority (BARDA) US 2020-04-07 2020-05-29 CV-CLN-003, NCT04372472, SQuISH-COVID Phase Not Applicable No longer recruiting 0 1 Month 300 Hollis R O'Neal, Jr., MD, MSc 2020-05-06
COVID Liver Coronavirus disease 19 infection, Liver disease Selayang Hospital Malaysia 2020-05-20 2020-06-30 54896, NMRR-20-856-54896 Phase Not Applicable Status not specified 1 1 Month Dr Tan Soek Siam 2020-05-08
CoNFINE: Limitations of social life in the context of the COVID-19 pandemic - Effects on physical performance and health-related quality of life of older people Coronavirus disease 19 infection Milon-circuit training alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Carl Von Ossietzky Universität Oldenburg Germany 2020-04-20 2020-061, CoNFINE, DRKS00021432 Phase Not Applicable Recruiting 1 100 Jessica Koschate, Tania Zieschang 2020-05-06
Evaluation of the Fluid Response of SARS-CoV-2 (COVID-19) Patients in Intensive Care; Pleth Variability Index Coronavirus disease 19 infection fluid management alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Erzincan University Turkey 2020-05-05 2020-06-15 EBYU COVİD PVI, NCT04373213 Phase Not Applicable Not yet recruiting 1 1 Month 30 ILKE KUPELI 2020-05-07
Max Ivermectin - COVID-19 Study Versus Standard of Care Treatment for COVID-19 Cases. A Pilot Study Coronavirus disease 19 infection ivermectin alone, standard treatment alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Max Healthcare Institute Ltd, India India 2020-04-25 2020-07-25 MHC-COVID-19- INV- ACT-BHR, NCT04373824 Phase 2 Clinical Recruiting 1 3 Months 50 Rajesh Saxena, MBA, Ram Shankar Mishra, DNB, FRCP, Sandeep Budhiraja, MRCP, FACP 2020-05-07
Duvelisib to Combat COVID-19 Coronavirus disease 19 infection, Respiratory failure duvelisib alone Phosphoinositide-3 kinase delta inhibitor, Phosphoinositide-3 kinase gamma inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US Verastem Oncology US 2020-06-30 2021-12-31 04-28-20-DIPERSIO, NCT04372602 Phase 2 Clinical Not yet recruiting 0 18 Months 25 Erik Dubberke, M.D., MSPH, John DiPersio, M.D., Ph.D., Mark Fiala, MSW 2020-05-07
CHIC: Covid High-intensity Immunosuppression in Cytokine release syndrome Coronavirus disease 19 infection, Viral pneumonia methylprednisolone plus tocilizumab Zuyderland Medical Center, Heerlen Netherlands 2020-04-23 2020-07-31 CHIC, NL8551 Phase Not Applicable Recruiting 1 3 Months 160 Sofia Ramiro 2020-05-07
BREATH: Breath Regulation and Yogic Exercise An Online Therapy for Calm and Happiness Anxiety disorder, Coronavirus disease 19 infection, Depression, Insomnia Health Enhancement Program alone, Sudarshan Kriya Yoga (SKY) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Lawson Health Research Institute Art Of Living foundation Canada 2020-05-10 2021-06-30 115855, BREATH, NCT04368676 Phase 0 Clinical Not yet recruiting 1 13 Months 60 Akshya Vasudev, MBBS, MD, Akshya Vasudev, MD, Emily Ionson, Hr.BSC 2020-05-06
CoVUm: Host-pathogen Interactions, Immune Response, and Clinical Prognosis at COVID-19 - the CoVUm Trial Coronavirus disease 19 infection blood sampling alone, urine and feces sampling alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Umea University Västerbotten County Council, Sweden Sweden 2020-04-28 2026-04-14 COVUM, CoVUm, NCT04368013 Phase Not Applicable Not yet recruiting 1 71 Months 400 Alicia Edin, M.D., Clas Ahlm, Professor, Johan Normark, Docent 2020-05-06
Hydroxychloroquine for Post-Exposure Prophylaxis of COVID-19 among naval personnel: a placebo-controlled, randomized, clinical trial Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University of Kelaniya Sri Lanka Navy, Ministry of Defense, State Pharmaceuticals Manufacturing Corporation of Sri Lanka Sri Lanka 2020-05-04 2020-05-31 P/22/04/2020, SLCTR/2020/011, U1111-1251-3613 Phase 4 Clinical Not yet recruiting 1 400 Niriella MA 2020-05-06
COVUSt: COVID19 ultrasound triage Coronavirus disease 19 infection Point-of-Care Ultrasound alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Isala Netherlands 2020-04-14 2020-06-01 COVUSt, NL8543 Phase Not Applicable Recruiting 1 1 Month 50 Svenja Haak 2020-05-06
PAPR: Prone Positioning in Awake Patients With COVID-19 Requiring Hospitalization Coronavirus disease 19 infection Prone Positioning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Utah US 2020-04-30 2021-01-31 IRB_00132123, NCT04368000, PAPR Phase Not Applicable Not yet recruiting 0 9 Months 60 Stacy A Johnson, MD 2020-05-07
ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Columbia University US 2020-04-18 2021-10-31 AAAS9998, NCT04367857 Phase Not Applicable Recruiting 0 18 Months 1000 Brett Gray, Magdalena Sobieszczyk, MD, MPH 2020-05-06
The PRONE study: Sleep position related to hospital length of stay in admitted COVID-19 patients Coronavirus disease 19 infection Sleep Position Trainer alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Franciscus Gasthuis & Vlietland 2020-04-17 2021-04-17 NL8538, The PRONE study Phase Not Applicable Planned 0 12 Months 342 Vivan Baggen 2020-05-06
A randomized, double-blind, placebo-controlled trial of intravenous plasma-purified alpha-1 antitrypsin for severe COVID-19 illness Coronavirus disease 19 infection plasma-purified alpha-1 antitrypsin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Royal College of Surgeons in Ireland Health Research Board Clinical Research Coordination Ireland Ireland 2020-04-24 2020-001391-15, V1Mar2020 Phase 2 Clinical Recruiting 1 Mandy Jackson 2020-05-07
NEUMONIA: Neurological Manifestations of COVID-19 and Indications of an Association with Respiratory Failure Coronavirus disease 19 infection, Respiratory failure neurological examination alone Zuyderland Medical Center, Heerlen Netherlands 2020-04-28 2020-07-31 METCZ20200077, NEUMONIA, NL8536 Phase Not Applicable Recruiting 1 3 Months 285 M. Beckers 2020-05-06
Functional status and health status in COVID-19 patients pre and post rehabilitation Coronavirus disease 19 infection rehabilitation alone CIRO TRADE PRIVATE LIMITED Netherlands 2020-03-30 2020-11-30 METC 2020-1340, NL8535 Phase Not Applicable Recruiting 1 8 Months 30 Anouk Vaes 2020-05-06
PredictCovid-D: Blood Biomarkers as Predictors of COVID-19 Disease Progression in Recently Infected Chronic Hemodialysis Patients Coronavirus disease 19 infection, Renal disease blood sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Nice France 2020-04-22 2021-02-22 20-PP-08, NCT04371510, PredictCovid-D Phase Not Applicable Recruiting 1 10 Months 115 SICARD Antoine, SICARD Antoine, Ph, sicard antoine, ph 2020-05-06
COVID-19 Health Messaging to Underserved Communities Coronavirus disease 19 infection Messaging alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over), African Ancestry, European Ancestry National Bureau of Economic Research Inc Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology, Stanford University, Yale University 2020-05-08 2021-06-30 2003000118, NCT04371419 Phase Not Applicable Not yet recruiting 0 13 Months 20000 2020-05-06
Evaluation of the therapeutic effect of a combination drug including apocynin, niacin, and tannin on COVID-19 Cardiovascular disease, Coronavirus disease 19 infection, Respiratory disease, Viral pneumonia current standard treatment alone, Variable regimens including apocynin , niacin , tannin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Isfahan University of medical Sciences Iran 2020-04-25 IR.MUI.MED.REC.1399.050, IRCT20200418047122N1 Phase 2/Phase 3 Clinical Recruiting 1 80 Dr Hossein Khanahmad, Dr Mehrdad Zeinalian, Dr Pourajam, Dr Shirani 2020-05-06
Usage of topical lignocaine to decrease the gag reflex while sampling for Covid-19: Does it affect the yield of specimen? Coronavirus disease 19 infection qualitative reverse transcription real-time Polymerase Chain Reaction test alone, lidocaine plus lignocaine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences India 2020-05-05 CTRI/2020/05/024983 Phase 2 Clinical Not yet recruiting 1 30 Alok Thakar, Dr Anupam Kanodia 2020-05-06
Effects of using hydroxychloroquine and azithromycin in the treatment of confirmed COVID-19 positive patients Coronavirus disease 19 infection azithromycin plus hydroxychloroquine Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) All India Institute of Medical Sciences, Raipur India 2020-05-15 CTRI/2020/05/024982 Phase 2 Clinical Not yet recruiting 1 50 Dr PUGAZHENTHAN T 2020-05-06
Evaluation of the Sleep Hygiene in the Lebanese Population During the COVID-19 Confinement Period Coronavirus disease 19 infection Sleep Hygiene Index questionnaire alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Saint Joseph's University Lebanon 2020-04-30 2020-09-30 CEHDF1650, NCT04372043 Phase Not Applicable Not yet recruiting 1 5 Months 1200 Jad Costa, Jeanine El Helou, MD, MSc 2020-05-07
CARDICoVRISK: Predictors of Cardiovascular Risk in COVID-19 Patients During Acute Disease and at Short-Term Follow-up Cardiovascular disease, Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto Auxologico Italiano Italy 2020-04-30 2020-09-10 CARDICoVRISK, CE_2020_03_26_02, NCT04371289 Phase Not Applicable Not yet recruiting 1 4 Months 5500 Gianfranco Parati, MD, PhD 2020-05-07
PREVENT: Prophylactic Benefit of Hydroxychloroquine in COVID-19 Cases With Mild to Moderate Symptoms and in Healthcare Workers With High Exposure Risk Coronavirus disease 19 infection hydroxychloroquine sulfate alone Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Texas Cardiac Arrhythmia Research Foundation US 2020-06-30 2021-07-31 NCT04371926, PREVENT, TCAI_PREVENT Phase Not Applicable Not yet recruiting 0 13 Months 64 Andrea Natale, Andrea Natale, MD, Angel Mayedo, MD, Bryan MacDonald, MD 2020-05-06
Effect of of Inhalation of Thyme Oil in COVID-19 Coronavirus disease 19 infection Variable regimens including hydroxychloroquine , lopinavir + ritonavir , thyme HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shoushtar School of Medical Sciences Iran 2020-05-04 IR.SHOUSHTAR.REC.1399.005, IRCT20200426047212N1 Phase 2/Phase 3 Clinical Recruiting 1 48 Ali Hatami, Barat Barati, Hassan Hassanzadeh Namin, Mohammad Nikzadian 2020-05-06
MG-COVID: Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients Coronavirus disease 19 infection standard of care alone, Plaquenil plus azithromycin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Assistance Publique Hopitaux de Paris France 2020-05-02 2020-09-02 2020-001702-35, APHP200447, MG-COVID, NCT04371406 Phase 3 Clinical Not yet recruiting 1 4 Months 2770 Alix PENEL, Julie CHASTANG, Dr, Sarra POCHON 2020-05-07
Study the effectiveness of concomitant use of vitamin C, metformin, azithromycin and doxycycline on improving patients with COVID-19 Coronavirus disease 19 infection Variable regimens including azithromycin , doxycycline hyclate , metformin hydrochloride , vitamin C AMP activated protein kinase stimulator Kermanshah University of Medical Sciences Iran 2020-05-09 IRCT20200418047121N1, ir.kums.rec.1399.079 Phase 3 Clinical Recruiting 1 40 Dr. Faizullah Mansouri, Dr. Farid Najafi, Dr. Kamran Mansouri 2020-05-11
Trifluoperazine Effectiveness in Treatment of Coronavirus Coronavirus disease 19 infection standard care alone, trifluoperazine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rasht University of Medical Sciences Iran 2020-05-04 2020-05-27 IR.GUMS.REC.1399.021, IRCT20200329046892N1 Phase 2/Phase 3 Clinical Recruiting 1 70 Nematollah Ahangar, Seyed Ali Alavi 2020-05-08
Genetics of COVID-19 Susceptibility and Manifestations Coronavirus disease 19 infection SNP chip assay alone, genome sequencing alone Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Human Genome Research Institute National Institutes of Health Clinical Center US 2020-05-13 2025-06-01 20-HG-0090, 200090, NCT04371432 Phase Not Applicable Recruiting 0 60 Months 2500 Julie Sapp, Leslie G Biesecker, M.D. 2020-05-09
CATCH COVID-19: Comparison of the Efficacy of Rapid Tests to Identify COVID-19 Infection Coronavirus disease 19 infection Serology test alone, Viral RNA test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Texas Cardiac Arrhythmia US 2020-05-31 2021-06-30 CATCH COVID-19, NCT04372004, TCAI_CATCH COVID-19 Phase Not Applicable Not yet recruiting 0 13 Months 100 Andrea Natale, Executive Medical Director, Deb Cardinal, RN MBA, MITRA Mohanty, MD 2020-05-11
Direct evidence of rectal cancer patient infected with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zhangnan Hospital China 2020-05-06 2020-05-16 ChiCTR2000032514 Phase Not Applicable Not yet recruiting 1 13 Jiang Congqing 2020-05-05
COVISLEEP: Impact of Neck Inspiratory Muscle Activation During Sleep in ICU Patients After a COVID-19 ARDS Coronavirus disease 19 infection, Respiratory distress syndrome neck inspiratory muscle (NIM) activation alone, polysomnography (PSG) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Bordeaux France 2020-04-30 2020-09-30 CHUBX 2020/14, COVISLEEP, NCT04371029 Phase Not Applicable Not yet recruiting 1 5 Months 25 Léo GRASSION, Dr, Renaud PREVEL, Dr 2020-05-06
Provider Burnout During COVID-19 Acute stress disorder, Coronavirus disease 19 infection coping strategies video alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Pittsburgh US 2020-04-29 2020-10-29 NCT04370938, STUDY20040051 Phase Not Applicable Recruiting 0 6 Months 250 Sara Myers, MD, Sara P Myers, MD, PhD 2020-05-06
Recruit Blood Donors Via SMS During Epidemic of COVID-19 Coronavirus disease 19 infection blood donation SMS alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Guangzhou Blood Center China 2020-04-30 2020-05-10 NCT04370886, RECRUIT BLOOD DONORS VIA SMS Phase Not Applicable Recruiting 1 394578 2020-05-05
Impact of the COVID-19 Pandemic on Diet Quality and Food Insecurity: a NutriQuebec Sub-study Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universite Laval Canada 2020-04-16 2020-05-07 2018-042PHASE IIA6/09-04-2020, NCT04371848 Phase Not Applicable No longer recruiting 1 2465 Benoît Lamarche 2020-05-04
A randomized, double-blind, placebo-controlled, Phase II/III trial to determine the safety and efficacy of DSTAT in COVID-19 patients with acute lung injury (ALI) Acute lung injury, Coronavirus disease 19 infection dociparstat (iv, AML/acute lung injury/COVID-19), Chimerix alone CXCR4 chemokine modulator, Cathepsin G inhibitor, Complement cascade inhibitor, Elastase inhibitor, Heparin agonist, High mobility group protein B1 inhibitor, L selectin antagonist, P selectin antagonist, Platelet factor 4 ligand inhibitor, Stromal cell-derived factor 1 ligand modulator Chimerix Inc 2020-04-29 Phase 2/Phase 3 Clinical Recruiting 0 524 2020-05-05
Effect of Formoterol in treatment of covid19 Coronavirus disease 19 infection formoterol(Medochemie Company) alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) National Research Institute of Tuberculosis and Lung Diseases Iran 2020-04-18 IR.SBMU.NRITLD.REC.1398.003, IRCT20170210032478N3 Phase 3 Clinical Recruiting 1 50 Dr. Parisa Farnia, Fariba Ghorbani, Giti Pourdoulat, Guitti Pourdowlat 2020-05-05
Study on data management and diagnosis-treatment mode of TCM intervention for novel coronavirus pneumonia (COVID-19) convalescence Coronavirus disease 19 infection, Viral pneumonia TCM intervention alone Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, National Science and Technology Support Plan of the People's Republic of China China 2020-04-29 2021-04-22 2020YFC0845000, ChiCTR2000032480, ChiMCTR2000003257 Phase Not Applicable Not yet recruiting 5 11 Months 1000 Liu Baoyan, Liu Jia 2020-05-05
Effect of interactive psycho-educational interventions on patients infected with COVID-19 Coronavirus disease 19 infection psycho-educational interventions alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shiraz University of Medical Sciences Iran 2020-05-14 IR.SUMS.REC.1399.012, IRCT20130616013690N7 Phase Not Applicable Not yet recruiting 1 50 Maryam Shaygan, Younes Ghasemi 2020-05-05
Evaluation of the efficacy of melatonin tablets as auxiliary medication in accelerating the improvement of the COVID-19 symptoms and clinical findings Coronavirus disease 19 infection hydroxychloroquine plus melatonin Gonabad University of Medical Sciences Iran 2020-04-14 IR.GMU.REC.1399.016, IRCT20200408046988N1 Phase 2/Phase 3 Clinical Recruiting 1 60 Najmeh Davoodian, Najmeh Davoudian, Shayla khosravan 2020-05-05
FORCE: Avdoralimab an Anti-C5aR Antibody, in Patients With COVID-19 Severe Pneumonia Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Viral pneumonia avdoralimab (IPH5401) alone CXCR1 chemokine antagonist, Complement C5a receptor antagonist, IL-8 receptor antagonist, Monocyte chemotactic protein 1 ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille Innate Pharma SA France 2020-04-27 2020-10-27 2020-001686-36, 2020-21, FORCE, NCT04371367 Phase 2 Clinical Recruiting 1 6 Months 108 Direction de la Recherche Santé, Emilie Garrido-Pradalie, Julien CARVELLI, Julien CARVELLI, MD, Nicolas, SCHLEINITZ, MD 2020-05-07
Clinical trial study on the therapeutic effect of Tenofovir besides Kaletra and Chloroquinein in patients with Coronavirus disease 2019 (COVID-19) Coronavirus disease 19 infection Variable regimens including alfamed tenofovir , chloroquine , lopinavir + ritonavir HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ahvaz University of Medical Sciences Iran 2020-04-18 IR.AJUMS.REC.1399.082, IRCT20200422047168N1 Phase 2/Phase 3 Clinical Recruiting 1 60 Ali Akbar Shayesteh, Ali akbar Shayesteh, Zahra Shokati 2020-05-06
KILLER: Povidone-iodine Mouthwash, Gargle, and Nasal Spray to Reduce Naso- Pharyngeal Viral Load in Patients With COVID-19 Coronavirus disease 19 infection povidone-iodine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Poitiers Etablissement D’Hospitalisation France 2020-05-01 2020-08-01 KILLER, KILLER, NCT04371965 Phase 2 Clinical Not yet recruiting 1 3 Months 24 Olivier MIMOZ, Professor, Sabrina SEGUIN, CRA 2020-05-05
Evaluation of the effect of Iranian medicine product, Algro, on patients with Coronavirus 19 Coronavirus disease 19 infection Algro alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bagheiat-allah University of Medical Sciences Iran 2020-05-04 2020-05-19 IR.BMSU.REC.1399.038, IRCT20160131026298N3 Phase 2/Phase 3 Clinical Recruiting 1 80 Ahmad Reza Sharifi Olounabadi, REZAMOHTASHAMI, AHMAD REZA SHARIFI OLOUNABADI, Reza Mohtashami 2020-05-05
SirCO-1: Sirolimus in COVID-19 Phase I Coronavirus disease 19 infection Standard medical care alone, sirolimus alone mTOR inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Thomas Jefferson University US 2020-05-31 2020-08-31 15680, NCT04371640, SirCO-1 Phase 1 Clinical Recruiting 0 3 Months 40 Angela C Pallotto, RN, BSN, Edwin Lam, PharmD, Walter K Kraft, MD 2020-05-08
Outcomes of Covid Protective Measures in Endoscopy Coronavirus disease 19 infection Covid PCR tests alone, endoscopy alone, protective protocol implementation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundación Pública Miguel Servet Spain 2020-04-27 2020-07-27 2020-COCHE, NCT04371354 Phase Not Applicable Not yet recruiting 2 3 Months 100 Juan J Vila, PhD, Ruth Garcia 2020-05-06
Evaluation effect of treatment with im (intramuscular) D3 on clinical, paraclinical symptoms and signs and inhospital outcome at patient admitted with COVID-19 Coronavirus disease 19 infection vitamin D alone Shahrood University of Medical Sciences Iran 2020-05-21 IR.SHMU.REC.1399.013, IRCT20200411047024N1 Phase 1/Phase 2 Clinical Not yet recruiting 1 100 Erfan Kazemi, Mohammad Hassan Emamian, hossien sheybani 2020-05-05
Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 Coronavirus disease 19 infection, Viral pneumonia hormones therapy alone, mechanical ventilation alone, oxygen therapy alone, supportive therapy alone, oseltamivir plus umbilical cord mesenchymal stem cells Exo-alpha sialidase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Fuzhou general hospital China 2020-03-01 2022-12-31 MSC-COVID-2020, NCT04371601 Phase 0 Clinical No longer recruiting 1 34 Months 60 Jianming Tan Tan, M.D and Ph.D 2020-05-05
A Study to Evaluate the Efficacy and Safety of Tocilizumab in Hospitalized Participants With COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia standard of care alone, tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Genentech Inc 2020-05-08 2020-10-05 ML42528, NCT04372186 Phase 3 Clinical Not yet recruiting 0 4 Months 379 Clinical Trials 2020-05-07
The COVID-ICU Healthcare Professional Study Coronavirus disease 19 infection electronic questionnaire on views and experiences alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Oslo University Hospital Norway 2020-05-06 2021-05-06 136144, NCT04372056 Phase Not Applicable Recruiting 2 12 Months 2200 Irene Lie, PhD, Siv Stafseth, PhD 2020-05-11
Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting Coronavirus disease 19 infection Variable regimens including azithromycin , doxycycline , hydroxychloroquine , zinc sulfate Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St. Francis Hospital, New York US 2020-04-28 2020-12-31 20-21, NCT04370782 Phase 4 Clinical Not yet recruiting 0 8 Months 750 Avni Thakore MD, Avni Thakore, MD, Elizabeth Haag, RN, Elizabeth S Haag, RN 2020-05-05
Risk Factors, Clinical Characteristics and Outcomes of Acute Infection With Coronavirus 2019 (COVID-19) In Children Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) St Jude Children's Research Hospital US 2020-04-27 2022-06-30 COVID-19, NCT04371315 Phase Not Applicable Recruiting 0 26 Months 400 Diego Hijano, MD 2020-05-05
Tocilizumab for Patients With Cancer and COVID-19 Disease Coronavirus disease 19 infection, Viral pneumonia tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Cancer Institute US 2020-05-01 2022-01-01 NCI-2020-02987, NCT04370834, TRC-10446 Phase 2 Clinical Not yet recruiting 0 20 Months 200 Richard F Little 2020-05-06
Study of Resilience and Loneliness in Youth (18 to 25 Years Old) During the COVID-19 Pandemic Lock-down Measures Coronavirus disease 19 infection, Psychiatric disorder Healthy volunteers accepted, Young Adults (18-44 yrs) Erasme Hospital King Baudouin Foundation, Universite Libre de Bruxelles Belgium 2020-04-30 2020-12-30 NCT04371250, SRB2020_158 Phase Not Applicable No longer recruiting 1 8 Months 800 2020-05-11
COVID-HO: Changes in Cardiac and Pulmonary Hemodynamics as Predictor of Outcome in Hospitalized COVID-19 Patients Coronavirus disease 19 infection endotracheal intubation and ventilation alone, non-invasive ventilation alone Universiteit Hasselt Belgium 2020-04-01 2020-12-01 COVID-HO, COVID-HO, NCT04371679 Phase Not Applicable Recruiting 1 8 Months 40 Lieven Herbots, Lieven Herbots, MD, PhD 2020-05-05
STC-19: Covid-19 Pandemic Triage Score Coronavirus disease 19 infection STC-19 score test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier de La Rochelle Numa Health International France 2020-03-01 2020-04-30 2020/P04/288, NCT04371471, STC-19 Phase Not Applicable No longer recruiting 1 2 Months 50 David Chalvet, MD, Jean-Claude Lapraz, MD, Kamyar M. Hedayat, MD, Serge Bénéteaud, MD 2020-05-06
EXPOCOVIA: Prevalence of COVID-19 Infection Among HCW in a French University Hospital Coronavirus disease 19 infection reverse transcription polymerase chain reaction (RT-PCR) alone, serological testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille Fondation Santé Roquette France 2020-04-30 2020-09-30 2020-A00951-38, 2020_35, EXPOCOVIA, NCT04371692 Phase Not Applicable Not yet recruiting 1 5 Months 100 Annie SOBASZEK, MD, Annie SOBASZEK, MD,PhD 2020-05-05
MSCs in COVID-19 ARDS Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure Standard of care alone, remestemcel-L alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mount Sinai Medical Center Mesoblast Ltd US 2020-04-30 2022-04-30 GCO 08-1078-0014, NCT04371393 Phase 3 Clinical Recruiting 0 24 Months 300 Abhijit Duggal, Alex Iribarne, MD, Alexis Mark, Annetine C Gelijns, PhD, Bradley Leshnower, MD, Chari Ponder, China Green, Christina Riggsbee, Denise Kosty-Sweeney, Edward Jauch, MD, Edward Lozano, Eustace Fernandes, MD, Guruprasad Jambaulikar, Hank Stokes, Hunter McDaniel, Jeffrey Sturek, MD, Jonathan Golob, MD, Kathleen Lane, Keren Osman, MD, Lydia McGowan, Manal Al-Suqi, Mary Beth Marks, Mary Lou Mayer, Michael Bowdish, MD, Michael Mack, MD, Mission Hospital, Nimesh Desai, MD, P. Eugene Parrino, MD, Peter Hou, MD, Peter Smith, MD, Rehma Shabbir, Robert Gottliebb, MD, Sharon Eichman, Sunjay Kaushal, MD 2020-05-08
Changes in Preference for Surgery of Patients Signed up for Arthroscopic Procedures Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Region Zealand Denmark 2020-04-17 2020-04-24 ARTHROCANCELLATIONSUH2020, NCT04370678 Phase Not Applicable Completed 1 79 Jesper S Nielsen, MD 2020-05-08
A trial to evaluate the effect of plasma therapy for the prevention and treatment of coronavirus infection Coronavirus disease 19 infection plasma therapy alone Columbia University Amazon.com Inc Phase 3 Clinical Status not specified 0 450 2020-05-04
COHIVE: Coronavirus (COVID-19) Outcomes in HIV Evaluation in Resource Limited Settings Coronavirus disease 19 infection, HIV infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Centre in HIV Epidemiology and Clinical Research The University of Liverpool, UNITAID, University of Montpellier, University of Witwatersrand France, South Africa, UK, Australia, Switzerland 2020-05-15 2021-12-31 2020-04-COHIVE, COHIVE, NCT04371835 Phase Not Applicable Not yet recruiting 5 19 Months 1500 Alexandra Calmy, MD, PhD, Emmanuelle Papot, MD, Eric Delaporte, MD, PhD, Francois WD Venter, MD, Joana Woods, MD, Maria E Arriaga, PhD, Mark Polizzotto, MD, PhD, Saye Khoo, MD, PhD 2020-05-05
ACCORD 2: A Phase II Study for the Treatment of COVID 19 in Hospitalized Patients Coronavirus disease 19 infection Variable regimens including MEDI-3506 , acalabrutinib , bemcentinib , zilucoplan Axl tyrosine kinase receptor inhibitor, Btk tyrosine kinase inhibitor, Complement C5 factor inhibitor, Interleukin 33 ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Southampton NHS Foundation Trust UK 2020-04-28 2020-001736-95, ACCORD 2, MasterACCORD-2-001subACCORD-2-002 Phase 2 Clinical Recruiting 1 825 Emma Perry 2020-05-06
London Ambulance Service Experience of COVID-19 Coronavirus disease 19 infection London Ambulance Service NHS Trust London School of Hygiene and Tropical Medicine UK 2020-04-09 2021-04-08 LAS-INT-2020-01, NCT04372069 Phase Not Applicable No longer recruiting 1 12 Months 40 Rachael Fothergill, PhD 2020-05-05
QT-Logs: Artificial Intelligence for QT Interval Analysis of ECG From Smartwatches in Patient Receiving Treatment for Covid-19 Coronavirus disease 19 infection artificial intelligence QT measurement alone, smartwatch ECG collection alone, azithromycin plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille France 2020-04-17 2020-05-11 CIL 2020-52, NCT04371744, QT-Logs Phase Not Applicable Recruiting 1 100 Jean Claude Deharo, MD 2020-05-06
HYdILIC: Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19 Coronavirus disease 19 infection antibiotic therapy alone, oxygen therapy alone, standard of care alone, steroid therapy alone, Variable regimens including diltiazem , hydroxychloroquine , niclosamide , paracetamol Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille University of Lille Nord de France France 2020-05-31 2023-05-31 2020-002188-72, 2020_40, HYdILIC, NCT04372082 Phase 3 Clinical Not yet recruiting 1 36 Months 480 Karine Faure, MD,PhD 2020-05-05
AMBU-COVID: Proactive Care of Ambulatory COVID-19 Patients Coronavirus disease 19 infection azithromycin alone, teleconsultation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens France 2020-04-29 2020-07-31 AMBU-COVID, NCT04371107, PI2020_843_0039 Phase 3 Clinical Not yet recruiting 1 3 Months 64 Jean-Philippe Lanoix, Jean-Philippe Lanoix, Pr 2020-05-07
Severity Score For COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Policlinico Universitario Agostino Gemelli Italy 2020-04-29 2020-05-27 3112, NCT04372199 Phase Not Applicable Recruiting 1 248 Massimo Montalto, Massimo Montalto, Professor 2020-05-05
Investigating the efficacy and safety of Hydroxychloroquine nasal spray in controlling the symptoms of patients with COVID-19 Coronavirus disease 19 infection Hydroxychloroquine nasal spray alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Baqiyatallah University of Medical Sciences Iran 2020-05-01 IR.BMSU.REC.1399.091, IRCT20080901001165N51 Phase 3 Clinical Recruiting 1 80 Nematollah Jonaidi, Parisa Kianpour, Yunes Panahi 2020-05-05
Effect of Deferiprone on the improvement of symptoms of Coronavirus 2019 (COVID-19) Coronavirus disease 19 infection deferiprone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sanandaj University of Medical Sciences Iran 2020-05-04 IR.MUK.REC.1399.012, IRCT20180114038350N3 Phase 3 Clinical Recruiting 1 80 Karim Naseri, Khaled Rahmani 2020-05-05
CO VOR IT: COVID-19: aaddition of azithromycin to chloroquine treatment Coronavirus disease 19 infection azithromycin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Erasmus University Medical Center Rotterdam Netherlands 2020-04-21 2020-001527-14, CO VOR IT Phase 4 Clinical Recruiting 1 60 J.G.J.V. Aerts 2020-05-07
CHAMPS: COVID-19 CHAMPS Study of Healthcare, First Responder and Service Workers Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Villanova University US 2020-04-27 2040-04-27 CHAMPS, IRB FY2020-215, NCT04370821 Phase Not Applicable Recruiting 0 240 Months 20000 Donna Havens, PhD,RN,FAAN, Janell Mensinger, PhD,FAED, Peter G. Kaufmann, PhD, Sandra Schultz 2020-05-08
DYNAMIC: Doxycycline Ambulatoire COVID-19 Coronavirus disease 19 infection GRANUDOXY alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CHU De Nantes France 2020-05-01 2020-12-01 DYNAMIC, NCT04371952, RC20_0191 Phase 3 Clinical Not yet recruiting 6 7 Months 330 Amir KHAMMARI, Amir Khammari, Anne DOMPMARTIN-BLANCHERE, Brigitte DRENO, Brigitte DRENO, PUPH, Eve MAUBEC, Fabrice BONNET, Lionel PIROTH, Marie-Thérèse Leccia 2020-05-11
TCM Intervention study for novel coronavirus pneumonia (COVID-19) patient during home/designate-unit isolation based on community prevention and control Coronavirus disease 19 infection, Viral pneumonia TCM Intervention alone Guang'Anmen Hospital China Academy of Chinese Medical Sciences, TCM China Academy of Traditional Chinese Medicine Institute of Medicine China 2020-02-03 2020-05-01 ChiCTR2000032478, ChiMCTR2000003256 Phase Not Applicable Recruiting 5 2 Months 3000 Liu Jia 2020-05-07
BCG-DENMARK-COVID: Using BCG Vaccine to Protect Health Care Workers in the COVID-19 Pandemic Coronavirus disease 19 infection BCG vaccine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bandim Health Project AJ Vaccines A/S, University of Southern Denmark Denmark 2020-05-31 2021-01-31 2020-001888-90, 20201504, BCG-DENMARK-COVID, BCG-DENMARK-COVID, NCT04373291 Phase 3 Clinical Not yet recruiting 1 8 Months 1500 Anne Marie Rosendahl Madsen, MD, Christine Stabell Benn, Professor, Clinical Institute, OPEN, Frederik Schaltz-Buchholzer, MD 2020-05-11
Experimental use of tocilizumab in COVID-19 related pneumonia Coronavirus disease 19 infection, Viral pneumonia standard of care alone, tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Clinique Inter-universitaire Ambroise Paré F Hoffmann-La Roche AG Belgium 2020-04-21 2020-001770-30, 2020COVID-19TCZ Phase 2 Clinical Recruiting 1 60 dr Camelia Rossi 2020-05-07
RECOP: Emergency Management in a Dedicated Respiratory Unit of Patients With a Possible COVID Infection (Unit 'COVID Possible') Coronavirus disease 19 infection, Dyspnea Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-03-13 2021-03-31 NCT04371328, RC31/20/0094, RECOP Phase Not Applicable Recruiting 1 12 Months 2000 Frédéric Balen, MD, Paul-Henri Auboiroux, MD 2020-05-11
Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19 Coronavirus disease 19 infection, Non-insulin dependent diabetes insulin plus linagliptin Dipeptidyl peptidase IV inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rabin Medical Center Israel 2020-05-15 2021-09-30 0303-20-RMC, NCT04371978 Phase 3 Clinical Not yet recruiting 2 16 Months 100 Alon Grossman, MD, Ran Abuhasira, Ran Abuhasira, MD 2020-05-11
Efficacy of Sn-protoporphyrin IX (SnPPIX) and Sulfonatoporphyrin(TPPS) Against Covid-19 Coronavirus disease 19 infection, Viral pneumonia Sn-protoporphyrin IX alone, sulfonated tetra-anthracenyl porphyrin alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kafrelsheikh University Egypt 2020-05-31 2020-08-31 NCT04371822, PROPOSED BY MAHMOUD ELKAZZ Phase 1 Clinical Not yet recruiting 1 3 Months 56 M.Sc. Mahmoud Elkazzaz, M.Sc.Biochemistry, M.Sc.Mahmoud Elkazzaz, M.Sc.Biochemistry, Mahmoud ELkazzaz 2020-05-11
Randomized, Double-Blind, Controlled Trial of Hydroxychloroquine as Post-Exposure Prophylaxis Against COVID-19 Infection Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sanford Health 2020-04-30 2023-04-20 NCT04372017, SH HCQ Phase 3 Clinical Not yet recruiting 0 35 Months 1739 Christie Ellison, BSN, Susan Hoover, MD 2020-05-10
BREATH: Vitamin D Polymorphisms and Severity of COVID-19 Infection Coronavirus disease 19 infection, Vitamin D deficiency Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidade de Lisboa Cardiovascular Centre of Universidade de Lisboa (CCUL), Cardiovascular Centre of Universidade de Lisboa (CCUL), Center for Health Technology and Services Research, Centro Hospitalar Sao Joao, HeartGenetics, Genetics & Biotechnology, S.A., Hospital de Santa Maria, Instituto Gulbenkian de Ciencia (IGC), Nova Medical School Portugal 2020-06-30 2021-03-31 BREATH, COVID19-BREATH, NCT04370808 Phase Not Applicable Not yet recruiting 2 9 Months 500 Ana Freitas, PhD, Ana Miranda, MD, Conceição Calhau, PhD, Fausto J Pinto, PhD, Fausto Pinto, PhD, Fátima Casaca, BSc, Helena Proença, MD, Melo Cristino, PhD, Tiago Guimarães, PhD 2020-05-08
Investigating the efficacy and safety of Azithromycin inhaled spray in controlling the symptoms of patients with COVID-19 Coronavirus disease 19 infection Azithromycin inhaled spray alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Baqiyatallah University of Medical Sciences Iran 2020-05-01 IR.BMSU.REC.1399.092, IRCT20080901001165N50 Phase 3 Clinical Recruiting 1 80 Morteza Izadi, Parisa Kianpour, Yunes Panahi 2020-05-08
A real-time, smartphone-based data collection study in order to uncover scientifically significant trends about the current coronavirus pandemic Coronavirus disease 19 infection smartphone-based data collection alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) American Lung Association, Northwestern University, University of California San Francisco Phase Not Applicable Recruiting 0 2020-05-04
PROVIDE: Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers Coronavirus disease 19 infection hydroxychloroquine sulfate alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Josephs Healthcare Hamilton Canada 2020-05-01 2020-08-30 3190, NCT04371523, PROVIDE Phase 3 Clinical Not yet recruiting 1 3 Months 1100 Kimberley Lewis, Waleed Al-Hazzani, Waleed Alhazzani 2020-05-05
Study for the water extract of soybean in the treatment of patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia soybean extract alone Wuhan University China 2020-03-01 ChiCTR2000030162 Phase 0 Clinical Terminated 1 2020-05-05
A phase I/IIa clinical study to assess cVLP vaccine in the treatment of patietns with COVID-19 infection Coronavirus disease 19 infection cVLP vaccine (COVID19 infection), AdaptVac alone AdaptVac EU Horizon 2020, ExpreS2ion Biotechnologies, Koebenhavns Universitet, Leiden University Medical Center, University Hospital Tubingen, Wageningen University and Research Phase 1/Phase 2 Clinical Planned 0 2020-05-04
Predicting Death and ICU Admission in COVID-19 Patients in ED Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Policlinico Universitario Agostino Gemelli Italy 2020-03-01 2020-04-15 0017055/20, NCT04371562 Phase Not Applicable Completed 1 1 Month 300 Francesco Franceschi, MD PhD 2020-05-06
J-COVID: Prospective, observational study on diagnosis and treatment of COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japanese Red Cross Medical Center Japan 2020-02-01 J-COVID, UMIN000040295 Phase Not Applicable Recruiting 1 100 Takehiro Izumo 2020-05-06
A clinical study of hydroxychloroquine versus the standard of care for the treatment in patients hospitalized with COVID-19 infection Coronavirus disease 19 infection hydroxychloroquine alone Male Food and Drug Administration US Phase Not Applicable Status not specified 0 368 2020-05-04
A pilot study to assess the clinical activity, safety and tolerability of Selective Cytopheretic Device (SCD) among patients who have ARDS prior to CRRT and/or AKI with CRRT Adult respiratory distress syndrome, Coronavirus disease 19 infection Selective Cytopheretic Device (SCD) alone Seastar Medical Inc Empiristat Inc. US 2020-04-28 SCD-005 Phase Not Applicable Recruiting 0 35 2020-05-05
Pharmacodynamics of the Nasalferon in healthy volunteers Coronavirus disease 19 infection recombinant interferon alfa 2b (Nasalferon) alone Healthy volunteers accepted, Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Center for Genetic Engineering and Biotechnology Ministerio de Salud Publica Cuba 2020-05-04 2020-06-09 IG / IAGN / VS / 2001, RPCEC00000308 Phase 1 Clinical Not yet recruiting 1 1 Month 30 Carlos Alberto GonzAlez Delgado, Hugo Nodarse Cuni 2020-05-05
Study for construction and assessment of early warning score of the clinical risk of novel coronavirus (COVID-19) infected patients Coronavirus disease 19 infection West China Hospital Science & Technology Department of Sichuan Province China 2020-01-01 2020-12-31 2020YFS0009, ChiCTR2000029907 Phase 0 Clinical Not yet recruiting 1 12 Months 1000 Yao, Rong 2020-05-05
Construction and Analysis of Prognostic Predictive Model of Novel Coronavirus Pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Zhangnan Hospital Hubei Clinical Research Center China 2020-02-01 2021-05-01 ChiCTR2000029953 Phase Not Applicable Not yet recruiting 1 15 Months 400 Xianlong Zhou, Yan Zhao 2020-05-05
HOPE study: Evaluation of the effect and safety of HeberFERON versus Heberon alfa in patients infected with the SARS-CoV-2 coronavirus (COVID-19) Coronavirus disease 19 infection HeberFERON alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Genetic Engineering and Biotechnology Ministerio de Salud Publica Cuba 2020-04-10 2020-07-30 HOPE study, IG / IAG / CV / 2001, RPCEC00000307 Phase 2 Clinical Recruiting 1 3 Months 120 Idelsis Esquivel Moynelo, Irraldo Bello Rivero 2020-05-05
Triple combination therapy in patients infected with COVID-19 Coronavirus disease 19 infection, Viral pneumonia Variable regimens including hydroxychloroquine sulfate , lopinavir + ritonavir , oseltamivir Exo-alpha sialidase inhibitor, HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gunma University Hospital Japan 2020-04-01 jRCTs031190227 Phase 2 Clinical Recruiting 1 50 Nakamura Tetsuya, Tokue Yutaka 2020-05-05
Favipiravir in patients infected with COVID-19 Coronavirus disease 19 infection, Viral pneumonia favipiravir alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gunma University Hospital Japan 2020-03-14 jRCTs031190226 Phase 2 Clinical Recruiting 1 50 Nakamura Tetsuya, Tokue Yutaka 2020-05-05
RACCO: A multicenter, open-label, randomized, controlled trial to evaluate the efficacy and safety of inhaled ciclesonide for asymptomatic and mild patients with COVID-19 Coronavirus disease 19 infection, Viral pneumonia ciclesonide alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japanese Ministry of Health, Labor and Welfare Japan 2020-04-03 RACCO, jRCTs031190269 Phase 2 Clinical Recruiting 1 90 Junko Terada, Sugiyama Haruhito 2020-05-05
Favipiravir for SARS-CoV-infected patients Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japan Agency for Medical Research and Development Japan 2020-03-02 jRCTs041190120 Phase 2 Clinical Recruiting 1 86 Doi Yohei, Kondo Masashi 2020-05-05
CHARTER: COVID-19: can nebulized heparin reduce time to extubation in SARS-CoV-2 patients requiring mechanical ventilation Coronavirus disease 19 infection heparin alone, invasive mechanical ventilation alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Vincents Hospital (Melbourne) Ltd Victorian State Government Australia 2020-05-21 2021-07-25 ACTRN12620000517976p, CHARTER Phase 3 Clinical Not yet recruiting 3 14 Months 172 Dr Barry Dixon 2020-05-05
SARS-CoV2 in children presenting to hospital: a repeating point prevalence study during the COVID-19 pandemic in South East Queensland Coronavirus disease 19 infection PCR alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Gold Coast Hospital Griffith University Australia 2020-04-29 2020-09-18 ACTRN12620000512921, HREC/2020/QGC/63198 Phase Not Applicable Not yet recruiting 1 4 Months 400 A/Prof Shane George 2020-05-05
ARDS Caused by COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinic of Barcelona Ubikare company Spain 2020-03-12 2020-12-31 COVID-19 ARDS, NCT04368975 Phase Not Applicable Recruiting 1 9 Months 500 Carlos Ferrando, Carlos Ferrando, PhD, Sara Darriba, PhD 2020-05-05
Clinical Application of Methylene Blue for Treatment of Covid-19 Patients Coronavirus disease 19 infection MCN (methylene blue, vitamin C, N-acetyl cysteine) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mashhad University of Medical Sciences Iran 2020-04-19 2020-09-21 IR.MUMS.REC.1399.122, NCT04370288 Phase 1 Clinical Recruiting 1 5 Months 20 Ahmad Bagheri Moghaddam, M.D, Amir Yarahmadi, Ph.D, Daryoush Hamidi Alamdari, Ph.D 2020-05-05
Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia Best Supportive Care alone, ravulizumab alone Complement C5 factor inhibitor, IgG receptor FcRn large subunit p51 modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Alexion Pharmaceuticals Inc 2020-05-06 2021-02-28 ALXN1210-COV-305, NCT04369469 Phase 3 Clinical Recruiting 0 9 Months 270 Alexion Pharmaceuticals, Inc. 2020-05-11
Repeated Measures Trial of Temporary Automated Manual Ventilation Versus Noninvasive Oxygenation or Conventional Vent Coronavirus disease 19 infection, Lung infection, Respiratory failure Mechanical ventilation alone, automated BVM compressor device, Spiro LLC/10x beta alone, rocuronium alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Massachusetts General Hospital 2020-05-31 2020-11-30 2020P001051, NCT04369274 Phase 2 Clinical Not yet recruiting 0 6 Months 30 Blair Parry, CCRC, Keith A Marill, MD 2020-05-05
BATTLE: COVID-19: BCG as Therapeutic Vaccine, Transmission Limitation, and Immunoglobulin Enhancement Coronavirus disease 19 infection BCG vaccine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidade Estadual de Campina Botucatu Medical School, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq, Faculdade de Medicina de Ribeirão Preto, Federal University of Sao Paulo, Instituto de Infectologia Emílio Ribas, Paulinia Municipal Hospital, Pontificia Universidade Catolica de Campinas, State Hospital Dr. Leandro Franceschini Brazil 2020-06-30 2022-05-31 BATTLE, COVID-19 BATTLE TRIAL, NCT04369794 Phase 4 Clinical Not yet recruiting 1 23 Months 1000 Bethania F Nascimento, BSN, Leonardo O Reis, MD, PhD 2020-05-04
Anxiety And Depression During COVID-19 In India Anxiety disorder, Coronavirus disease 19 infection, Depression Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India India 2020-04-24 2021-02-24 COVID-19/MHC/PSYCH/20-10, NCT04369300 Phase Not Applicable Not yet recruiting 1 10 Months 1000 2020-05-04
MATCH: Multi-site Adaptive Trials Using Hydroxycholoroquine for COVID-19 Coronavirus disease 19 infection famotidine plus hydroxychloroquine Histamine H2 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Northwell Health Inc US 2020-04-07 2021-04-07 20-0268, MATCH, NCT04370262 Phase 3 Clinical Recruiting 0 12 Months 1170 Amanda Tice, RN, Asha Mellor, CCRC, Christina Brennan, MD, John Boockvar, MD, Joseph Conigliaro, MD, Julie DiGregorio, CCRP, Negin Hajizadeh, MD, Neubert Philippe, MD, Patricia Nadraus, RN, Richard Dima, MD, Tamika Wong, MPH 2020-05-06
Trans Thoracic Manipulation of Ventilation/Perfusion: the V/Q Vest Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Respiratory failure V/Q Vest alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Emory University Georgia Institute for Clinical Research, Georgia Institute of Technology US 2020-05-31 2021-03-31 NCT04369599, STUDY00000402 Phase Not Applicable Not yet recruiting 0 10 Months 24 Maxwell Weinmann, MD 2020-05-04
Curie-O-SA: COVID-19 Study of the Serological Response Against the Severe Acute Respiratory Syndrome (SARS) Coronavirus 2 (CoV-2) Virus in 2 Types of Employees, Hospital and Non-hospital, at Institute Curie Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut Curie France 2020-04-28 2021-01-28 Curie-O-SA, IC 2020-07, NCT04369066 Phase Not Applicable Recruiting 1 9 Months 2500 Isabelle Turbiez, Olivier Lantz, MD, Pierre Fumoleau, PhD 2020-05-04
XPro-1595 for the Treatment of Pulmonary Complications From COVID-19 Coronavirus disease 19 infection, Lung disease INB-03 alone, standard of care alone TNF alpha ligand inhibitor Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) INmune Bio Inc 2020-06-30 2021-01-31 NCT04370236, XPRO1595-COVID-19 Phase 2 Clinical Not yet recruiting 0 7 Months 150 Christopher Barnum, PhD 2020-05-05
COVID-19.KDIR.01: Long-term Analysis and Evaluation of morphologic and clinical Parameters in COVID-19 Patients: prospective development of a practical risk score Coronavirus disease 19 infection, Viral pneumonia CT scan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stuttgart Cancer Center Germany 2020-04-17 COVID-19.KDIR.01, DRKS00021537, F-2020-047, U1111-1251-0942 Phase Not Applicable Recruiting 1 150 Götz Martin Richter 2020-05-04
SARS-CoV-2 in tears in patients with COVID-19 Coronavirus disease 19 infection, Ocular disease RT-PCR assay alone, funduscopy alone, slit-lamp examination alone Universitatsklinikum Schleswig-Holstein Campus Kiel Germany 2020-04-29 D 469/20, DRKS00021416 Phase Not Applicable Recruiting 1 30 Mr. Prof. Dr. med. Johann Baptist Roider, Ms. Dr. med. Kristin Hosel 2020-05-04
ATHLOS: Telerehabilitation in Patients With COVID-19 After Hospitalization Coronavirus disease 19 infection aerobic exercise alone, breathing exercise alone, resistive training exercise alone, telerehabilitation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Clinical Exercise Physiology and Rehabilitation Reasearch Laboratory University of Athens, University of Ioannina, University of Thessaly Greece 2020-04-30 2021-03-31 1, ATHLOS, NCT04368845 Phase Not Applicable Not yet recruiting 1 11 Months 100 ELENI KAPRELI, PhD, PT, ELENI KORTIANOU, PhD, PT, Eleni Kortianou 2020-05-04
Management of Covid-19 Patients During Home Isolation Coronavirus disease 19 infection oxygen alone, physical therapy alone Young Adults (18-44 yrs) Cairo University Egypt 2020-03-15 2020-05-20 2318087, NCT04368923 Phase 2 Clinical No longer recruiting 1 2 Months 60 Mahmoud Sedky 2020-05-04
COVID-OZO: Ozone Auto-hemotherapy for COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia ozone auto-hemotherapy alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) L'Institut d Investigacio Biomedica de Girona Hospital Nuestra Señora del Rosario, Sociedad Española de Ozonoterapia Spain 2020-05-04 2020-12-25 COVID-19 NETWORKING GROUP, COVID-OZO, NCT04370223 Phase 3 Clinical Not yet recruiting 9 7 Months 208 Alberto Hernández, MD, PhD, Antònia Flor, MD, Eduardo Tamayo, MD, PhD, Isabel Guitart, MD, Javier Ripolles, MD, PhD, Marc Vives, MD, Marc Vives, MD, PhD, Miguel Angel Garcia, MD, Noelia Zurera Plaza, MD 2020-05-06
JoCORE: Acute Cardiovascular Events Triggered by COVID-19-Related Stress Acute stress disorder, Cardiovascular disease, Coronavirus disease 19 infection, Myocardial infarction, Shock, Sudden cardiac death, Ventricular tachycardia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jordan Collaborating Cardiology Group Jordan 2020-05-03 2020-08-30 JCCG.JOCORE.4.4040, JoCORE, NCT04368637 Phase Not Applicable Recruiting 6 3 Months 50 Ayadeh Madanat, MD, Ayman Hammoudeh, MD, FACC, Ayman J Hammoudeh, MD, FACC, Ayman J. Hammoudeh, MD, FACC, Eyadeh Madanat, MD, Hadi Abu Hantash, MD, FACC, Hadi Abu hantash, MD, FACC, Imad Alhaddad, MD, Mahmoud Fakhri, MD, Mahmoud Izraiq Mahmoud Izraiq, MD, Walaa Abu Moghli, PharmD, Zaid Khouri, MD, Zeina Abu Orabi, MD 2020-05-06
VIRUS: Construction of a Composite Clinical-echo Score Predictive of a Risk of Short-term Aggravation of Respiratory Impairment in Patients Suspected of Covid-19 Coronavirus disease 19 infection, Respiratory failure clinical-echo score prediction alone, pleuro-pulmonary ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CHU De Nantes WINFOCUS-France France 2020-04-09 2020-06-30 NCT04370249, RC20_0164, VIRUS Phase Not Applicable Recruiting 1 2 Months 400 Philippe LE CONTE, Philippe LE CONTE, MD-PHD, Philippe PES, MD 2020-05-04
CONFIDODO: Sleep Quality During COVID-19 Containment in Children Whether or Not Usually Followed in Child Psychiatry Anxiety disorder, Coronavirus disease 19 infection, Depression, Sleep disorder routine psychiatric care alone Healthy volunteers accepted, Children (6-12 yrs) Centre Hospitalier René-Dubos France 2020-05-31 2020-06-30 CHRD 0520, CONFIDODO, NCT04370210 Phase Not Applicable Not yet recruiting 1 1 Month 464 Erwan VION, Maryline Delattre, Véronique Da Costa 2020-05-09
Project D: Observational Study to Assess the Seroconversion Status of Health Care Workers and Suspected or Confirmed Cases of COVID-19 Patients Coronavirus disease 19 infection COVID-19 testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India India 2020-04-22 2020-07-30 COVID-19/MHC-2/2020, NCT04368884, Project D Phase Not Applicable Recruiting 1 3 Months 1000 Samreen Siddiqui, PhD, Sujeet Jha, MRCP (U.K), Swati Waghdhare, MD 2020-05-04
Observational Study of COVID-19 Treatment Efficacy Coronavirus disease 19 infection, Respiratory distress syndrome hydroxychloroquine alone, remdesivir alone, azithromycin plus hydroxychloroquine Coronavirus non structural protein 8 modulator, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) OSF Healthcare System US 2020-04-14 2021-04-14 1589936, NCT04369989 Phase Not Applicable Recruiting 0 12 Months 1000 David Hall 2020-05-04
TEACH: Treating COVID-19 With Hydroxychloroquine Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) NYU Langone Health SUNY Downstate Medical Center US 2020-04-15 2020-06-30 20-00463, NCT04369742, TEACH Phase 2 Clinical Recruiting 0 2 Months 626 Jack A. DeHovitz, MD, MPH, MHCDS, FACP, Mark Mulligan, MD, Mark Mulligan, MD, FIDSA, Robert Ulrich, MD 2020-05-04
COVERSCAN: Mapping Organ Health Following COVID-19 Disease Due to SARS-CoV-2 Infection Coronavirus disease 19 infection MRI alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Perspectum Diagnostics Ltd UK 2020-04-21 2023-05-31 20/SC/0185, COVERSCAN, NCT04369807 Phase Not Applicable Recruiting 2 37 Months 507 Mary Norris Xu, BSc, RN, Rajarshi Banerjee, MSc, DPhil, Sandeep Kapur, BSc, MBBS 2020-05-11
Evaluation of the Safety and Immunogenicity of a SARS-CoV-2 rS (COVID-19) Nanoparticle Vaccine With/Without Matrix-M Adjuvant Coronavirus disease 19 infection SARS-CoV recombinant vaccine (nanoparticle), Novavax alone, Matrix M plus SARS-CoV recombinant vaccine (nanoparticle), Novavax Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Novavax Inc Australia 2020-05-15 2021-07-31 2019NCOV-101, NCT04368988 Phase 1/Phase 2 Clinical Not yet recruiting 2 14 Months 131 Biljana Georgievska 2020-05-04
Stroke-Covid19: Covid-19 Epidemic on Acute Stroke Management Coronavirus disease 19 infection, Stroke Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-03-03 2020-04-30 7826, NCT04370197, Stroke-Covid19 Phase Not Applicable Recruiting 1 1 Month 300 Raoul POP, MD, Rémy BEAUJEUX, MD, PhD, Saïd CHAYER, PhD, HDR 2020-05-04
PROTECT: Improving prenatal care during confinement Coronavirus disease 19 infection, Parturition remote consultation alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France 2020-05-01 2021-09-30 2020-A01023-36, NCT04368832, PROTECT Phase Not Applicable Not yet recruiting 0 17 Months 108 Gaëlle Ambroise, Nadine JUGE 2020-05-04
Study to Describe the Safety, Tolerability, Immunogenicity, and Potential Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Adults Coronavirus disease 19 infection Variable regimens including BNT-162a1 , BNT-162b1 , BNT-162b2 , BNT-162c2 COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) BioNTech SE Pfizer Inc US 2020-04-29 2023-01-27 C4591001, NCT04368728 Phase 1/Phase 2 Clinical Recruiting 0 32 Months 7600 Pfizer CT.gov Call Center 2020-05-09
Hydroxychloroquine Chemoprophylaxis for COVID-19 Infection in High-risk Healthcare Workers Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) SERVICES INSTITUTE OF MEDICAL SCIENCES Pakistan 2020-05-15 2020-10-15 16082019, NCT04370015 Phase 2 Clinical Not yet recruiting 1 5 Months 374 Khadija I Khawaja, FCPS, Saira Burney, FRCP (Edin) 2020-05-07
CORRECT: COvid (Covid-19) Registry REChts der Isar intensive care Trial Adult respiratory distress syndrome, Coronavirus disease 19 infection extracorporeal organ support alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Technical University of Munich Germany 2020-03-30 178/20S, CORRECT, DRKS00021612 Phase Not Applicable Recruiting 1 500 Sebastian Rasch 2020-05-04
TeleCoviDiab: Management of Diabetic Patients With Telemedicine in the Context of the Covid-19 Epidemic Coronavirus disease 19 infection, Insulin dependent diabetes, Non-insulin dependent diabetes teleconsultation alone, telemedicine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital of Strasbourg France 2020-05-31 2020-12-31 7775, NCT04370171, TeleCoviDiab Phase Not Applicable Not yet recruiting 1 7 Months 200 Eric DEMONSANT 2020-05-06
SeCo: Screening for SARS-CoV-2-Infections and Monitoring of Serological Responses to SARS-CoV-2 in Healthcare Workers Coronavirus disease 19 infection Anti-SARS-CoV2 S protein IgG ELISA alone, SARS-CoV-2 PCR alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Medicine Greifswald EUROIMMUN GmbH, Friedrich Loeffler Institute Germany 2020-04-27 2025-05-31 BB 068/20, NCT04370119, SeCo Phase Not Applicable Recruiting 2 61 Months 4000 Andreas Greinacher, Prof.Dr., Christine Rutscher, Dipl.-Med., Henry Völzke, Prof.Dr., Karsten Becker, Prof.Dr., Lena Ulm, Dr., Marek Zygmunt, Prof.Dr., Martin Beer, Prof.Dr., Martin Groschup, Prof.Dr., Matthias Nauck, Prof.Dr., Mladen V. Tzvetkov, Prof.Dr., Nicole Endlich, Prof.Dr., Nils-Olaf Hübner, Prof.Dr., Thomas C. Mettenleiter, Prof.Dr., Wolfgang Schlumberger, Dr. 2020-05-04
PAN-COVID: A global registry of women affected by COVID-19 in pregnancy and their babies, to guide treatment and prevention Coronavirus disease 19 infection Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Imperial College London United Kingdom Research & Innovation Spain, Italy, Hungary, United Arab Emirates, Qatar, Ireland, Australia, Portugal, Ecuador, India, Israel, Egypt, Estonia, Chile, Greece, Canada, Argentina, Malta, Peru, Thailand, Uganda, Latvia, Bosnia and Herzegovina, Colombia, Nigeria, Guatemala, Tunisia, South Africa, Brazil, Netherlands, Austria, Czech Republic, Belgium, Indonesia, Germany, Russian Federation, UK, Japan, Lebanon, Mexico, Romania, US 2020-01-01 2021-09-30 20QC5917, IRAS 282655, ISRCTN68026880, PAN-COVID Phase Not Applicable Recruiting 42 21 Months 1000 Dr Mullins 2020-05-11
POCUSars-CoV-2: Accuracy of Lung Ultrasound in the Diagnosis of COVID-19 Pneumonia Coronavirus disease 19 infection, Respiratory disease, Viral pneumonia lung ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Latisana Hospital Italy 2020-04-23 2020-05-31 CEUR-2020-OS-086, NCT04370275, POCUSars-CoV-2 Phase Not Applicable Recruiting 1 1 Month 235 Carmine C Di Gioia, MD, Daniele Orso, MD, Roberto Copetti, MD, Director 2020-05-04
In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity Coronavirus disease 19 infection Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Applied Biology Inc Hospital Universitario Ramon y Cajal Spain 2020-05-01 2020-12-01 AB-IVD-COV-001, NCT04368897 Phase Not Applicable Recruiting 1 7 Months 200 Andy Goren, MD, Carlos Wambier, MD, Sabina Herrera, MD 2020-05-11
Hungarian CoronaVirus Disease-19 Epidemiological Research Coronavirus disease 19 infection Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Semmelweis University Heart and Vascular Center Semmelweis University, University Of Pécs, University of Debrecen, University of Szeged Hungary 2020-05-01 2021-08-01 H-UNCOVER, NCT04370067 Phase Not Applicable Not yet recruiting 4 15 Months 11200 Andor Sebestyén, MD,PhD, Annamaria Kosztin, MD,PhD, Béla Merkely, PhD,DSc, Csaba Lengyel, MD,PhD, Ervin László Berényi, MD,PhD 2020-05-04
Radiographic Findings and Their Temporal Changes in COVID-19 Positive Changes Patients: a Prospective Study Coronavirus disease 19 infection real time reverse transcriptase polymerase chain reaction(rRT-PCR) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Max Healthcare Institute Ltd, India India 2020-04-28 2021-05-30 COVID-19/RFTC/MHC/2020, NCT04368871 Phase Not Applicable Not yet recruiting 1 13 Months 200 Bharat Aggarwal, Rajesh Saxena 2020-05-05
GROCO: Obstetric and Perinatal Outcomes of Women With COVID-19 Coronavirus disease 19 infection Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille France 2020-04-23 2021-04-22 2020-18, GROCO, ID RCB, NCT04369859 Phase Not Applicable Recruiting 1 12 Months 1300 Florence BRETELLE, PU-PH, Jean-Olivier ARNAUD, Director 2020-05-05
C5-COV: C5a Receptor Expression - COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille Innate Pharma SA France 2020-03-31 2020-11-30 2020-14, C5-COV, IDRCB, NCT04369820 Phase Not Applicable Recruiting 1 8 Months 100 Emilie EGP GARRIDO-PRADALIE, Julien CARVELLI, Julien JC CARVELLI, MD, Kahéna AMICHI, Kahéna KA AMICHI, Laurent PAPAZIAN, Lionel VELLY, Marc GAINNIER, Nicolas SCHLEINITZ, Pierre-Yves CORDIER 2020-05-05
C19Survey: The Psychological, Social, and Economic Impacts of COVID-19 Coronavirus disease 19 infection, Psychiatric disorder online survey alone Healthy volunteers accepted, Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Ottawa CHEO Research Institute, Centre for Addiction and Mental Health, Ciusss du Nord-De-L'île-De-Montréal, Hopital Du Sacre-Coeur De Montreal, Johns Hopkins University, McGill University, Ottawa Heart Institute Research Corp, Ottawa Hospital Research Institute, Southlake Regional Health Centre, Sunnybrook Health Sciences Centre, The Royal's Institute of Mental Health Research, Universite De Montreal Canada 2020-04-03 2021-04-03 2131, C19Survey, NCT04369690 Phase Not Applicable Recruiting 10 12 Months 1000 Addo Boafo, MD, Alexander Daros, PhD, CPsych, Cynda Rushton, RN, PhD, Denis Lafortune, PhD, Edward Spilg, FRCP, MSc, Elizaveta Solomonova, PhD, Janet Jeffrey, RN, PhD, Jennifer Phillips, PhD, Jodi Edwards, PhD, Kaitlyn Lopes, Lena Quilty, PhD, CPsych, Mamta Gautam, FRCP MBA, Marie-Hélène Pennestri, PhD, Mysa Saad, MSc, Raj Bhatla, MD FRCPC, Richard H Swartz, MD, PhD, Richard Swartz, MD, PhD, Roger Godbout, PhD, Rébecca Robillard, Rébecca Robillard, PhD, Samuel Paul Louis Veissière, PhD, Tetyana Kendzerska, MD PhD, Tetyana Kendzerska, MD, PhD, Wendy Gifford, RN, PhD, Zachary Kaminsky, PhD 2020-05-04
DigitalDoc: The Digital Doc in the Emergency Department: The solution for patient care in the Covid-19 pandemic? Coronavirus disease 19 infection telemedicine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Maxima Medical Center Netherlands 2020-04-08 2020-09-01 DigitalDoc, NL8522 Phase Not Applicable Recruiting 1 4 Months 50 Bart Candel 2020-05-04
Neuroinvasion in COVID-19 Coronavirus disease 19 infection, Respiratory disease RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zuyderland Medical Center, Heerlen Netherlands 2020-04-26 2020-06-26 NL8526 Phase Not Applicable Not yet recruiting 1 2 Months 10 Floris Smeets 2020-05-04
Volatile Anesthetics in COVID-19 – a pilot study Coronavirus disease 19 infection, Respiratory distress syndrome isoflurane alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitair Medisch Centrum Utrecht Netherlands 2020-04-26 2020-05-31 NL8523 Phase 2 Clinical Not yet recruiting 1 1 Month 20 Jan Dieleman 2020-05-04
Duke COVID-19 Shared Data and Specimen Repository Coronavirus disease 19 infection Duke University US 2020-05-05 2025-04-30 NCT04368234, PRO00105316 Phase Not Applicable Recruiting 0 59 Months 100000 Chris Woods, MD, Lynn Sutton 2020-05-04
COVILUS: Lung Ultrasound to Diagnose COVID-19 Coronavirus disease 19 infection, Respiratory failure lung ultrasound alone, reverse transcription polymerase chain reaction test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens France 2020-04-28 2020-09-28 COVILUS, NCT04368338, PI2020_843_0030 Phase Not Applicable Recruiting 1 5 Months 100 Stéphane Bar, Dr, Stéphane Bar, MD 2020-05-04
SCOPe: To Study the Clinical Characteristics and Treatment Outcome of COVID-19 Patients Admitted in Hospitals of Max Healthcare Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Healthcare Institute Ltd, India, Max Super Speciality Hospital India 2020-04-25 2020-07-25 CTRI/2020/04/024859, NCT04367064, SCOPE/MHC/COVID-19/2020, SCOPe Phase Not Applicable Recruiting 1 3 Months 1000 Dr Ram Shankar Mishra, Rajesh Saxena, Rajesh Saxena, MBA, Ram Shankar Mishra, DNB, FRCP, Sandeep Budhiraja, MRCP, FACP 2020-05-04
ELCOVID: Electrocardiogram Analysis in COVID-19 Patients Cardiovascular disease, Coronavirus disease 19 infection blood test alone, cardiac magnetic resonance imaging alone, radiographic examination alone, transthoracic echocardiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Ospedaliero-Universitaria di Ferrara Italy 2020-04-14 2021-12-01 385/2020/OSS/AOUFE, ELCOVID, NCT04367129 Phase Not Applicable Recruiting 1 19 Months 1000 Matteo Bertini, MD, PhD, Michele Malagù, MD 2020-05-06
EuroECMO-COVID: European/Euro-ELSO Survey on Adult and Neonatal/Pediatric COVID-19 Patients in ECMO Cardiogenic shock, Coronavirus disease 19 infection, Lung disease, Septic shock extracorporeal membrane oxygenation alone Maastricht University Medical Center Antwerp University Hospital, Azienda Ospedaliera Citta della Salute e della Scienza di Torino, Azienda Ospedaliero-Universitaria Ospedali Riunit, Azienda Ospedaliero-Universitaria di Udine, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Cardiocentro Ticino, Centre Hospitalier Universitaire Saint Pierre, Centre Hospitalier Universitaire de Liege, Centro Hospitalar Sao Joao, Charles University, Chelyabinsk Regional Clinical Hospital, City Clinical Hospital No. 67, Moscow, Russia, City Hospital No 40, City Hospital No 41, Ekaterinburg, Department of Cardiovascular Surgery, German Heart Center Munich, Erasme Hospital, Erasmus University Medical Center Rotterdam, European chapter of the Extracorporeal Life Support Organization, G Gaslini Children's Hospital, G. Pasquinucci Heart Hospital, Massa, General University Hospital, Prague, Great Ormond Street Hospital for Children NHS Foundation Trust, Guy's & St Thomas' Hospital NHS Trust, Hannover Medical School, Heart Center Leipzig GmbH, Heim Pal Children's Hospital, Henri Mondor Hospital, Herlev Hospital Region Hovedstaden, Hopital Prive La Louviere, Hopital Universitaire de la Pitie Salpetriere, Hopitaux Universitaires De Geneve, Hospices Civils De Lyon, Hospital Miguel Servet, Hospital San Gerardo, Hospital Sant Joan de Deu, Hospital Universitario Ramon y Cajal, Hospital Vall D'Hebron, Hôpital Civil Marie Curie de Charleroi, IRCCS Policlinico San Matteo, Istituto Scientifico H San Raffaele, Karolinska University Hospital, Kemerovo Regional Clinical Cardiological Center named after academician L.S. Barbarash, Klinik Hirslanden, Klinikum Kassel GmbH, Krasnodar Regional Hospital no 1, Landesklinikum Sankt Polten, Leiden University Medical Center, Medical University of Vienna, Medical University of Warsaw, Newcastle Upon Tyne Hospitals NHS Trust, Niguarda Hospital, Novosibirsk City Hospital #2, Onze-Lieve-Vrouwziekenhuis Aalst Hospital, Ospedale Maurizio Bufalini, Ospedale Papa Giovanni XXIII, Ospedale Pediatrico Bambino Gesù (IRCCS), Ospedale S. Giovanni Bosco, Ospedale San Donato, Ospedale Umberto, Ospedale dell'Angelo, Paediatric Intensive Care Glasgow, Politecnico Di Milano, Rennes University Hospital, Rijksuniversiteit te Groningen, Royal Brompton & Harefield NHS Trust, San Bortolo Hosp, San Camillo Hospital, Rome, San Giorgio Clinic, Skåne University Hospital, St. Orsola Hospital, The Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Tirol Kliniken, Universitair Medisch Centrum Utrecht, Universitair Ziekenhuis Brussel, Universitair Ziekenhuis Gent, Universitaire Ziekenhuizen Leuven, Universitat Duisburg Essen, Universitatsklinikum Essen, University General Hospital of Alexandroupolis, University Hospital Basel, University Hospital Regensburg, University Hospital Tubingen, University Hospital, Aachen, University Hospital, Bordeaux, University Hospital, Montpellier, University Hospitals of Leicester - Leicester Royal Infirmary, University of Bern, University of Erlangen-Nurnberg Medical School, University of Lausanne Hospitals, University of Zurich, Universitätklinikum Düsseldorf, Universitätsklinikum Koln, Vilnius University Hospital Santariškių Klinikos Lithuania, Netherlands, Austria, Germany, Switzerland, Sweden, Belgium, France, UK, Hungary, Czech Republic, Portugal, Spain, Russian Federation, Israel, Poland, Greece, Denmark, Italy 2020-04-10 2021-04-30 EuroECMO-COVID, METC 2020-1343, NCT04366921 Phase Not Applicable Recruiting 97 12 Months 150 Aaron Blandino, Ortiz, Alain Combes, Prof., Alberto Weber, Prof. Dr., Alessandro Paradiso, Dr., Alexander Kersten, Dr., Alexander Skopets, Alexandr Turchaninov, Alexandra Shilova, Allesandro Circelli, Dr., Andrea Montalto, Dr., Andrea Moscatelli, Angelo Polito, Antioco Cappai, Dr., Antonella Degani, Antonio Loforte, Dr., Aron Frederik Popov, Prof., Bernard Stockman, Dr., Christian Napp, Dr., Christoph Krapf, Dr., Claire Westrope, Daniel De Backer, Dr., Daniil Shelukhin, Dario Candura, Dr., Dario Fina, Dr., David Schibilsky, Dr., Davide Ghitti, Dr., De Piero, Drs., Dimitri Vandeweghe, Dimitrios Soufleris, Dinis Reis Miranda, Dr., Diyar Saeed, Prof., Edgars Grins, Esther Dreier, Dr., Fabio Taccone, Prof., Felix Hennig, Dr., Finn Moeller Pedersen, Dr., Gabriel Saiydoun, Dr., Gerdy Debeuckelaere, Giacomo Cavallaro, Gianluca Agus, Dr., Gil Bolotin, Dr., Giovanni Chiarini, Dr., Giovenni Landoni, Grünenfelder Jürg, Prof. Dr., Halbe Maximillian, Dr., Harlinde Peperstraete, Ignazio Condello, Igor Komilov, Ivan Akufov, J.J. van der Heijden, Dr., Jacinta Maas, Dr., Jan Belohlavek, Prof., Jan Schmitto, Prof., Jenni Hansjoerg, Jolanda Consiglio, Jordi Riero del Brio, Dr., Judit Llevadias, Justyna Swol, Dr., Katherine Brown, Lars Broman, Dr., Leen Vercaemst, Dr., Lo Coco, Drs., Lorusso, Prof. Dr., Luis Filipe Pinto, Dr., Maged Makhoul, Dr., Malaika Mendoca, Mara Scandroglio, Marc Lagny, Marco Giani, Dr., Marco Moscarelli, Dr., Marco Piccichè, Marco Ranucci, Dr., Maria Elena De Piero, Dr., Mariusz Kowaleswsky, Dr., Mark Davidson, Martin Kneyber, Matteo Di Nardo, Matteo Pozzi, Dr., Matthias Thielman, Prof., Maximillian Malfertheiner, Dr., Michael Piagnerelli, Mirko Belliato, Dr., Nicholas Bartlett, Dr., Nikolaos Bonaros, Prof., Olivier Brissaud, Olivier Germay, Pablo Ruiz, Dr., Paolo Del Sarto, Paolof Meani, Dr., Patrick Biston, Dr., Peter Schellongowski, Dr., Philipp Hen, Dr., Phillipe Gaudard, Pierre Tissieres, Ralf Muellenbach, Prof, Reina Gianfranco, Dr., Robertas Samalavicius, Dr., Roberto Carozza, Roberto Rona, Dr., Romain Courcelle, Roman Komelyuk, Sandrelli Luca, Dr., Sandro Sponga, Dr., Sergei Minin, Simone Schafer, Dr., Susana Segura Matute, Sven Maier, Dr., Thierry Folliguet, Prof., Thomas Doebele, Torje Iuliu, Dr., Udo Boeken, Prof., Vaclav Vobruba, Verna Aquino, Veronika Maraczi, Vito Fanelli, Dr., Xavier Bechtold 2020-05-04
COVID-19 outbreak and solid organ transplantation (SOT): an international, web-based survey Coronavirus disease 19 infection, Organ transplantation Policlinico Universitario Agostino Gemelli Italy 2020-03-24 2020-04-17 COVID-19_V1, NCT04367896 Phase Not Applicable Completed 1 1819 2020-05-01
COVID PRAYER: The COVID-19 ICU PRAYER Study Coronavirus disease 19 infection remote intercessory multi-denominational prayer alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kansas City Heart Rhythm Institute US 2020-05-01 2020-08-31 COVID PRAYER, COVID PRAYER STUDY, NCT04361838 Phase Not Applicable Not yet recruiting 0 4 Months 1000 Dhanunjaya Lakkireddy, MD, Donita Atkins, RN, BSN 2020-05-01
COVID19-CHIEF: COVID-19 Infection in Patients With Hepatocellular Carcinoma Coronavirus disease 19 infection, Hepatocellular carcinoma, Viral pneumonia nasopharyngeal Covid-19 RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens Central Hospital, Nancy, France, Centre Hospitalien Sud Francilien, Centre Hospitalier Intercommunal Creteil, Centre Hospitalier Regional Universitaire de Lille, Centre Hospitalier Universitaire De Nice, Centre Hospitalier Universitaire De Poitiers Etablissement D’Hospitalisation, Centre Hospitalier Universitaire de Toulouse, Hospices Civils De Lyon, Hospital Boisguillaume, Hôpital Paul Brousse, Jean Verdier Hospital, Rennes University Hospital, University Hospital, Bordeaux, University Hospital, Grenoble, University Hospital, Montpellier France 2020-04-27 2020-10-31 COVID19-CHIEF, NCT04367805, PI2020_843_0042 Phase Not Applicable Recruiting 1 6 Months 50 Aurore BARON, MD, Christine SILVAIN, Pr, Eric ASSENAT, Pr, Eric NGUYEN KHAC, Pr, Giuliana AMADDEO, MD, Jean Pierre BRONOWICKI, Pr, Jean-Frédéric BLANC, MD, Jean-Marie PERON, Pr, Julien EDELINE, MD, Mohamed BOUATTOUR, MD, Nathalie GANNE-CARRIE, Pr, Olivier GANRY, Pr, Olivier Ganry, Pr, Philippe MATHURIN, Pr, Philippe MERLE, Pr, Pierre MICHEL, Pr, Rodolphe ANTY, Pr, Thomas DECAENS, Pr, Éric VIBERT, Pr 2020-05-01
ColchiVID: Colchicine Twice Daily During 10 Days as an Option for the Treatment of Symptoms Induced by Inflammation in Patients With Mild and Severe Coronavirus Disease Coronavirus disease 19 infection, Inflammatory disease colchicine (Perrigo) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Instituto Nacional de Ciencias Medicas y Nutricion Mexico 2020-04-27 2021-04-27 337420-21-1, ColchiVID, NCT04367168 Phase 2 Clinical Not yet recruiting 1 12 Months 174 Jose J Torres-Ruiz, MD, MSc, Marina Rull-Gabayet, MD 2020-05-05
Performance of 3 Sampling Methods for the Detection of SARS-CoV-2 (COVID-19) With Real-time Reverse Transcriptase PCR Coronavirus disease 19 infection Dry flocked nasopharyngeal Swab alone, Flocked nasopharyngeal eSwab alone, Flocked oropharynx eSwab alone Healthy volunteers accepted Jessa Hospital Belgium 2020-04-20 2020-05-20 20.43, NCT04361448 Phase Not Applicable Not yet recruiting 1 1 Month 30 Koen Magerman, Reinoud Cartuyvels 2020-05-04
COHORT: Covid-19 Hospitalized Patients Registry Coronavirus disease 19 infection University Hospital Halle Germany 2020-05-03 2020-039, COHORT, DRKS00021575 Phase Not Applicable Not yet recruiting 1 750 Daniel Sedding 2020-05-01
COVBIO: Thrombosis and Covid-19 Coronavirus disease 19 infection, Thrombosis thromboelastometry alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2020-05-01 2020-12-31 69HCL20_0401 - COVBIO, COVBIO, ID-RCB, NCT04366778 Phase Not Applicable Recruiting 1 8 Months 300 Yesim DARGAUD, Pr, Yseim DARGAUD, Pf 2020-05-07
Social Media and COVID-19 Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yale-NUS College Singapore 2020-03-08 2020-05-31 2020-CERC-001B, NCT04367363 Phase Not Applicable Recruiting 1 2 Months 150 Jean Liu, PhD 2020-05-01
Cardiac Injury in COVID-19: a Pathology Study Coronavirus disease 19 infection, Heart injury, Lung disease, Myocardial infarction, Myocarditis, Pulmonary heart disease EKG alone, RNAscope in situ hybridization alone, autopsy alone, cardiac catheterization alone, cardiac sampling alone, dual immunofluorescence alone, echocardiography alone, reverse transcription polymerase chain reaction alone, transmission electron microscopy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ospedale Papa Giovanni XXIII CVPath Institute Italy 2020-04-30 2021-03-31 56/20, NCT04367792 Phase Not Applicable Recruiting 1 11 Months 50 Andrea Gianatti, MD, Antonio Bellasi, MD, CTC CLINICAL TRIAL CENTER, Giulio Guagliumi, MD, Lara Faggi, PhD 2020-05-04
MARCO: A Phase Ib/II, Randomized, Placebo-Controlled, Dose-Finding Study Followed by a Dose Level Expansion to Assess the Safety and Efficacy of NoveCite MSCs in Subjects with Acute Respiratory Distress Syndrome (ARDS) Due to SARS-CoV-2 Disease (COVID-19) Coronavirus disease 19 infection, Respiratory distress syndrome Allogeneic NoveCite mesenchymal stem cell therapy (acute respiratory distress syndrome/COVID-19), Citius Pharmaceuticals alone Citius Pharmaceuticals Inc US MARCO Phase 1/Phase 2 Clinical Planned 0 2020-05-04
X-Covid 19: Comparison of Two Doses of Enoxaparin for Thromboprophylaxis in Hospitalized COVID-19 Patients Coronavirus disease 19 infection, Thromboembolism enoxaparin sodium alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Niguarda Hospital Italy 2020-05-31 2020-11-30 2020-001708-41, NCT04366960, X-Covid 19 Phase 3 Clinical Not yet recruiting 1 6 Months 2712 Nuccia Morici, MD 2020-05-02
A double-blinded, randomized and placebo-controlled study of trans sodium crocetinate (intravenous), Diffusion Pharmaceuticals in hospitalized COVID-19 patients who have not yet been admitted to an ICU Coronavirus disease 19 infection trans sodium crocetinate (intravenous), Diffusion Pharmaceuticals alone Diffusion Pharmaceuticals LLC, West Virginia University Healthcare US, Eastern Europe Phase Not Applicable Planned 0 Dr. Alex Kadl, Dr. Andrew Southerland 2020-04-30
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection Coronavirus disease 19 infection, Respiratory distress syndrome remestemcel-L alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mesoblast International Sarl Mesoblast Ltd US MSB-MSC-ARDS001, NCT04366830 Phase Not Applicable No longer recruiting 0 50 Mahboob Rahman, MD 2020-05-02
A phase I/II clinical trial for inactivated novel coronavirus (2019-CoV) vaccine (Vero cells) Coronavirus disease 19 infection COVID-19 vaccine (inactivated, Vero cells/intramuscular), Beijing Biological Products Institute/National Institute for Viral Disease Control and Prevention of Chinese Center for Disease Control and Prevention alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Beijing Biological Products Institute Co Ltd, China National Pharmaceutical Group Corporation, Henan Center for Disease Control and Prevention Ministry of Science and Technology of the People´s Republic of China China 2020-04-28 2021-11-28 ChiCTR2000032459 Phase 1/Phase 2 Clinical Recruiting 1 19 Months 2128 Wei Wang, Yanxia Wang 2020-05-06
LUCID: Lung Ultrasound in Covid-19 Pneumonia Coronavirus disease 19 infection, Cough, Dyspnea, Respiratory disease, Viral pneumonia computed tomography alone, lung ultrasoound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Vivantes Humboldt-Klinikum Germany 2020-04-24 DRKS00021585, Eth08-20, LUCID Phase Not Applicable Recruiting 1 220 Andreas Umgelter 2020-05-02
SARS-CoV-2 and Surgery Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jagiellonian University Poland 2020-03-30 2020-07-01 1072.6120.103.2020, NCT04368026 Phase Not Applicable Recruiting 2 3 Months 350 Tomasz Stefura, Tomasz Stefura, MD 2020-05-02
A larger, double-blinded, randomized, placebo-controlled study of trans sodium crocetinate (intravenous) to confirm safety in COVID-19 patients who have been admitted to Intensive Care Units (ICUs) Coronavirus disease 19 infection trans sodium crocetinate (intravenous), Diffusion Pharmaceuticals alone Diffusion Pharmaceuticals LLC, West Virginia University Healthcare US Phase Not Applicable Planned 0 Dr. Alex Kadl, Dr. Andrew Southerland 2020-04-30
COR-DIAL-1: Rapid Detection of COVID-19 by Portable and Connected Biosensor Coronavirus disease 19 infection RT-PCR alone, nasopharyngeal swab sampling alone, viral biosensor alone Centre Hospitalier Regional Universitaire de Lille France 2020-05-31 2020-09-30 2020-A01147-32, 2020_36, COR-DIAL-1, NCT04367142 Phase Not Applicable Not yet recruiting 1 4 Months 200 David Devos, MD,PhD, Enagnon Kazali ALIDJINOU, MD 2020-05-02
MolCOVID: Development of a Molecular Diagnostic Strategy for SARS-CoV2 Based on Saliva in the Context of the COVID-19 Pandemic Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Boisguillaume France 2020-04-30 2020-05-31 2020/0094/OB, MolCOVID, NCT04367545 Phase Not Applicable Recruiting 1 1 Month 50 Julien BLOT, Thierry FREBOURG, Pr 2020-05-01
EVIDENCE: COVID-19 Detection Test in Oncology Coronavirus disease 19 infection, Solid tumor enzyme-linked immunosorbent assay (ELISA) alone, rapid diagnostic test (RDT) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The UNICANCER Group France 2020-05-31 2021-05-31 2020-A01002-37, EVIDENCE, NCT04367870, UC-TRA-2002 Phase Not Applicable Not yet recruiting 11 12 Months 2500 Alexandra JACQUET, Aurélien NORET, François-Clément BIDARD, Frédéric VIRET, Georges EMILE, Jean-Baptiste BACHET, Jean-Marc FERRERO, Lionel MOREAU, WILLIAM JACOT 2020-05-03
ScreenNC: A Study to Determine the Number of Asymptomatic Individuals Who Have Antibodies to the Virus That Causes COVID-19 Coronavirus disease 19 infection COVID-19 testing alone, PCR test alone, sequencing alone, swab test alone, viral load testing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of North Carolina US 2020-04-28 2021-04-30 20-0937, NCT04367740, ScreenNC Phase Not Applicable Recruiting 0 12 Months 10000 David B Peden, MD 2020-05-01
ACCORD: ACcelerating COVID-19 Research and Development platform Coronavirus disease 19 infection bemcentinib alone Axl tyrosine kinase receptor inhibitor BerGenBio AS Department of Health and Social Care, IQVIA Holdings Inc, United Kingdom Research & Innovation UK ACCORD Phase 2 Clinical Not yet recruiting 1 120 2020-05-05
BACT-ovid: Bacteriotherapy in the Treatment of COVID-19 Coronavirus disease 19 infection bacteriotherapy alone, Variable regimens including SivoMixx , azithromycin , darunavir , darunavir + cobicistat , hydroxychloroquine , lopinavir + ritonavir , ritonavir Cytochrome P450 3A4 inhibitor, HIV protease inhibitor, HIV-1 protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universita degli Studi di Roma La Sapienza Italy 2020-03-01 2020-07-31 BACT-ovid, DPHID-UNIROMA05, NCT04368351 Phase Not Applicable No longer recruiting 1 5 Months 70 Gabriella d'Ettorre, MD, PhD, Giancarlo Ceccarelli 2020-05-05
Comorbidites among COVID-19 Mortality Cases Coronavirus disease 19 infection National Institutes of Health Malaysia Malaysia 2020-04-30 54554, NMRR-20-766-54554 Phase Not Applicable Status not specified 1 Hamizatul Akmal Binti Abd Hamid, P Robert Lourdes, Tania Gayle 2020-05-01
Influenza Vaccination, ACEI and ARB in the Evolution of SARS-Covid19 Infection Coronavirus disease 19 infection angiotensin converting enzyme inhibitor therapy alone, angiotensin-receptor blocker therapy alone, influenza vaccine alone Healthy volunteers accepted Consorci Sanitari de Terrassa Catalan Health Service, Jordi Gol i Gurina Foundation Spain 2020-03-01 2023-08-31 02-20-161-021, NCT04367883 Phase Not Applicable Recruiting 1 42 Months 2574 Anna Puigdellívol-Sánchez, Ph D, Anna Puigdellívol-Sánchez, Ph.D., Mar Muñoz 2020-05-02
Health Behavior Change During COVID-19 Pandemic Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) SWPS University of Social Sciences and Humanities Malaysia, Singapore, China, France, Portugal, Italy, Gambia, Poland, Canada, Romania, Israel, Germany, Switzerland, Australia 2020-03-25 2021-03-24 3228-1BPSYPSBEH-30, NCT04367337 Phase Not Applicable Recruiting 14 12 Months 5600 Adriana Baban, PhD, Aleksandra Luszczynska, PhD, Bruno Quintard, PhD, Charles Abraham, PhD, Jan Keller, PhD, Karen Morgan, PhD, Katarzyna Byrka, PhD, Konstadina Griva, PhD, Konstantin Schenkel, MA, Margarida Gaspar de Matos, PhD, Martyna Kuszneruk, MA, Michelle Jongenelis, PhD, Nina Knoll, PhD, Noa Vilchinsky, PhD, Sabrina Cipolletta, PhD, Stephan Dombrowski, PhD, Urte Scholz, PhD, Vishna Shah, PhD, Yiquin Gan, PhD, Yiqun Gan, PhD, Zofia Szczuka, MA 2020-05-02
Stigmatization of Covid-19 patients Coronavirus disease 19 infection Hospital Raja Permaisuri Bainun Malaysia 2020-06-01 54697, NMRR-20-777-54697 Phase Not Applicable Status not specified 1 Chang Chee Tao, Ms. Chew Chii Chii 2020-05-02
Psychological Impairment Due to Covid-19 Anxiety disorder, Coronavirus disease 19 infection, Depression, Psychiatric disorder Healthy volunteers accepted Universitatsklinikum Essen 2020-05-06 2020-05-30 NCT04368312, TEMP553914-BO Phase Not Applicable Not yet recruiting 0 100 Johannes Siebermair, MD 2020-05-02
COVIVA: COVID-19 Survival Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Basel Switzerland 2020-03-19 2021-06-30 COVIVA, NCT04366765, UHOSPITAL SWITZ Phase Not Applicable Recruiting 2 15 Months 1500 Christian Mueller, MD, Christian Nickel, MD, Gabriela Kuster Pfister, MD, Hans Pargger, MD, Katharina Rentsch-Savoca, MD, Martin Siegemund, MD, Mirjam Christ Crain, MD, Raphael Twerenbold, MD, Roland Bingisser, MD, Sarah Tschudin-Sutter, MD, Stefan Osswald, MD, Stefano Bassetti, MD 2020-05-05
SAVIOR: Study Assessing Vagus Nerve Stimulation in COVID-19 Respiratory Symptoms Coronavirus disease 19 infection, Respiratory disease GammaCore alone, vagus nerve stimulation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Valencia Spain 2020-04-20 2020-07-31 NCT04368156, SAVIOR, SAVIOR Phase Not Applicable Recruiting 1 3 Months 90 Carlos Tornero, Carlos Tornero, PhD, Natividad Pozo, PhD 2020-05-01
IMPROVE: Intermediate or Prophylactic-Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19 Coronavirus disease 19 infection, Thromboembolism enoxaparin sodium alone, unfractionated heparin alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Columbia University US 2020-05-31 2021-04-30 AAAS8980, IMPROVE, NCT04367831 Phase 4 Clinical Not yet recruiting 0 11 Months 100 Ajay Kirtane, MD, Kate Dalton, Sahil A. Parikh, Sahil Parikh, MD 2020-05-04
Registry to Study Factors That May Impact COVID-19 Occurrence and Severity Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) IQVIA RDS Pty Ltd US 2020-04-02 2022-06-01 IQVIA-COVIDREGISTRY-2020, NCT04368065 Phase Not Applicable Recruiting 0 26 Months 100000 Barbara Arone, MS, Nancy Dreyer, PhD, MPH 2020-05-01