Last updated: Jun 18, 2020 - 02:00 BST

Title Indication Intervention Actions PatientSelection Sponsor Collaborator Country StartDate EndDate Identifiers Phase Recruitment Status Sites Trial Duration Enrollment Count Contacts LastChanged
A study to assess the effect of PIKfyve inhibitors for the treatment of COVID-19 infection Coronavirus disease 19 infection PIKfyve inhibitors, Verge Genomics Inc alone Verge Genomics Inc Phase Not Applicable Planned 0 2020-06-16
Effects of patients' vision and emotions on covid-19 Coronavirus disease 19 infection, Depression, Vision disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Universiti Kebangsaan Malaysia Malaysia 2020-06-15 54953, NMRR-20-1123-54953 Phase Not Applicable Status not specified 0 DR Bannu A/P Jayallan, Dr. Nor Fariza Ngah 2020-06-16
Personality traits, depression, work stress, frontliners, Covid-19 Acute stress disorder, Coronavirus disease 19 infection, Depression Tuanku Jaafar Hospital Malaysia 54720, NMRR-20-875-54720 Phase Not Applicable Status not specified 0 Hj. Binaw Samad 2020-06-16
Incidence of ADR Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Sungai Buloh Malaysia 2020-06-09 55048, NMRR-20-1120-55048 Phase Not Applicable Status not specified 0 2020-06-16
ICRAD: ICRAD Coronavirus disease 19 infection, Rheumatoid arthritis Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sarawak General Hospital Malaysia 2020-07-01 2021-01-01 55262, ICRAD, NMRR-20-1116-55262 Phase Not Applicable Not yet recruiting 0 6 Months 15 Dr Sharifah Aishah bt Wan Mohamad Akba 2020-06-16
Children with disability during the COVID-19 outbreak Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of Hong Kong Community Child Health Unit Hong Kong 2020-03-23 HKUCTR-2872, UW 20-178, protocol v1-20200306 Phase Not Applicable Not yet recruiting 1 1356 Dr. Wan-yee Winnie Tso, HKUCTR Administrator 2020-06-16
RoKiCo: Prospective study to evaluate immunity to SARS-CoV2 in mothers with children in child-care facilities Coronavirus disease 19 infection biological sampling alone, polymerase chain reaction alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Universitätsmedizin Rostock Germany 2020-04-23 A 2020-0090, DRKS00021614, RoKiCo Phase Not Applicable Recruiting 1 400 Dagmar Michel-Lubs, Emil C. Reisinger 2020-06-16
Effects of COVID-19 on lung function and gas exchange Coronavirus disease 19 infection, Interstitial lung disease, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gesellschaft für Tauch- und Überdruckmedizin e.V, University Hospital, Bonn Klinik f. Lungenheilkunde und Beatmungsmedizin, Rhein-Maas Klinikum GmbH Germany 2020-06-16 179/20, DRKS00022082 Phase Not Applicable Not yet recruiting 1 124 Ivanna Rühl, Lars Eichhorn 2020-06-16
PROFLO: Could prone positioning increase lung function for patients with severe COVID-19 infection? Coronavirus disease 19 infection, Hypoxia, Respiratory failure, Viral pneumonia high flow nasal cannula alone, noninvasive ventilation alone, prone positioning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Uppsala County Council University Hospital of Uppsala Sweden 2020-04-20 2021-06-25 1, ISRCTN54917435, PROFLO Phase Not Applicable Not yet recruiting 3 14 Months 240 Dr Rosen 2020-06-16
Influence of the Covid-19 pandemic on the patient mix in German emergency departments Coronavirus disease 19 infection BundeswehrKrankenhaus Ulm Klinikum WolfsburgZentrale Notfallaufnahme, Otto-von-Guericke-Universität Magdeburg, Universitätsklinik für Unfallchirurgie, Otto-von-Guericke-Universität Magdeburg, Universitätsklinik für Unfallchirurgie,AKTIN-Notaufnahmeregister, RWTH Aachen, Institut für Medizinische Informatik,AKTIN Notaufnahmeregister Germany 2020-07-01 160/15, DRKS00022188 Phase Not Applicable Not yet recruiting 1 500000 Martin Kulla, Wiebke Schirrmeister 2020-06-16
Efficacy and Safety of Sofosbuvir/Daclatasvir treatment in COVID-19: A randomized, controlled study Coronavirus disease 19 infection, Viral pneumonia Standard of care therapy alone, Daktavera plus Gratisovir Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) PHARCO CORPORATE Egypt 2020-06-20 DRKS00022203, IRB0000687, U1111-1253-0458 Phase 2/Phase 3 Clinical Not yet recruiting 1 90 Mostafa Yakoot 2020-06-16
The role of children in transmission of COVID19 pandemic: Two case series in Malaysia Coronavirus disease 19 infection Hospital Sungai Buloh Malaysia 2020-06-01 2020-08-06 NMRR-20-1087-55233 Phase Not Applicable Status not specified 1 2 Months Dr LIM SOK BEE 2020-06-16
Approachs and issues on Corona Disaster for EAP Coronavirus disease 19 infection Psychological education alone Healthy volunteers accepted ADVANTAGE Risk Management Co., Ltd. Japan 2020-06-15 UMIN000040762 Phase Not Applicable Not yet recruiting 1 100 Suzuki Junya 2020-06-16
Children During the COVID-19 Outbreak Coronavirus disease 19 infection Preschool Children (2-5 yrs), Children (6-12 yrs) The University of Hong Kong Community Child Health Unit Hong Kong 2020-03-23 HKUCTR-2871, UW 20-177, v1-20200305 Phase Not Applicable Not yet recruiting 1 1356 Dr. Winnie Tso, HKUCTR Administrator 2020-06-16
Scientific guidance for risk-control and prevention of COVID-19 in professional soccer-players in Austria Coronavirus disease 19 infection RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Paracelsus Medical University Austria 2020-05-18 415-EP/73/820-2020, DRKS00022166 Phase Not Applicable Recruiting 1 250 Dagmar Schaffler 2020-06-16
A real-time national survey OF COVID-19 in hemoglobinopathy and rare inherited anemia patients Anemia, Coronavirus disease 19 infection, Sickle cell anemia, Thalassemia Queen Mary University of London UK Phase Not Applicable Status not specified 1 2020-06-16
GI IN COVID-19 Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Queen Elizabeth Malaysia 2020-05-18 2020-12-31 54764, NMRR-20-869-54764 Phase Not Applicable Recruiting 1 7 Months 200 Dr Ho Yoke Fun 2020-06-16
Psychosocial experiences among quarantined healthcare workers Coronavirus disease 19 infection Universiti Malaysia Sarawak Malaysia 2020-07-01 2020-09-30 54833, NMRR-20-1144-54833 Phase Not Applicable Not yet recruiting 2 3 Months Prof. Chew Keng Sheng 2020-06-16
Studying tobacco use and quitting behavior due to the coronavirus lockdown in India Coronavirus disease 19 infection interviewer-administered telephone-based survey alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HRIDAY, Public Health Foundation of India University of Edinburgh India 2020-06-20 CTRI/2020/06/025850, HMSC proposal ref id: 2020-9500 Phase Not Applicable Not yet recruiting 1 800 Dr Monika Arora, Prof K Srinath Reddy 2020-06-16
RNB in UPUMS, Saifai Coronavirus disease 19 infection RNB (Raj Nirvan Bati) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Uttar Pradesh University of Medical Sciences India 2020-06-14 CTRI/2020/06/025852 Phase 1/Phase 2 Clinical Not yet recruiting 1 Dr Raj Kumar 2020-06-16
Mental Health of children during COVID-19 Pandemic Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs) ESI Post Graduate Institute of Medical Science and Research (PGIMSR) India 2020-06-17 CTRI/2020/06/025853 Phase Not Applicable Not yet recruiting 1 100 Jyoti Bagla, Mahima Rajan 2020-06-16
BCG for COVID-19: BCG Vaccination against COVID-19 Coronavirus disease 19 infection, Respiratory disease BCG vaccine alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Indian Council of Medical Research India 2020-06-25 BCG for COVID-19, CTRI/2020/06/025854, Version 3.2 Phase 4 Clinical Not yet recruiting 6 1450 C Padmapriyadarsini, Dr Anant Mohan, Dr Asha Keetharam, Dr C Padmapriyadarsini, Dr R R Tiwari, Dr Rujuta Hadaye, Dr Toteja, Srikanth Tripathy 2020-06-16
FLARE: A randomised, double-blind, 2×2 factorial placebo-controlled trial on the saftey and efficacy Favipiravir, lopinavir/ritonavir combination therapy in early antiviral therapy in COVID-19 infection Coronavirus disease 19 infection favipiravir plus lopinavir + ritonavir HIV protease inhibitor, RNA polymerase inhibitor University of London LifeArc UK FLARE Phase Not Applicable Status not specified 1 2020-06-15
Short-term Outcome of COVID-19 Surgical Patients: Case-series of a High-risk Area Community Hospital Coronavirus disease 19 infection surgical procedure alone Azienda Socio Sanitaria Territoriale di Lodi Italy 2020-05-01 2020-05-30 COVID19NR1, NCT04430062 Phase Not Applicable Completed 1 14 Michele Ballabio 2020-06-16
Clinical Analysis of Patients Hospitalized Due To COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) TNMC and BYL Nair Hospital India 2020-06-21 CTRI/2020/06/025848 Phase Not Applicable Not yet recruiting 1 1500 Minal Harde, Rakesh Bhadade 2020-06-15
Study to Evaluate the Safety and Efficacy of a Combination of Nitazoxanide and Hydroxychloroquine Versus Hydroxychloroquine Alone in COVID-19 Patients Coronavirus disease 19 infection hydroxychloroquine plus nitazoxanide Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Dr Reddy's Laboratories Ltd India 2020-06-15 CTRI/2020/06/025849, CVD-19-CD-001 Phase 2 Clinical Not yet recruiting 1 158 D Mallikarjuna Rao, Dr Apurva Agarwal 2020-06-15
Safety, Tolerability and Efficacy of Nangibotide in Mechanically Ventilated Patients With COVID-19 and Features of Systemic Inflammation Coronavirus disease 19 infection, Inflammatory disease, Respiratory failure nangibotide alone, standard of care alone TREM receptor 1 antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Inotrem SA France 2020-06-30 2021-03-31 MOT-C-204, NCT04429334 Phase 2 Clinical Not yet recruiting 1 9 Months 60 Jean-Jacques Garaud, MD, Sébastien Gibot, MD 2020-06-15
Pre-Identified Homoeopathic Medicines In Asymptomatic Covid -19 Individuals Receiving Standard Treatment Protocol Coronavirus disease 19 infection Standard treatment alone, Variable regimens including Arsenicum album 30 , Bryonia 30 , Camphora 1M Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Central Council for Research in Homoeopathy India 2020-06-22 CTRI/2020/06/025844 Phase 2/Phase 3 Clinical Not yet recruiting 1 Dr Anil Khurana, Dr Varanasi Roja 2020-06-16
Registry for a Cardiovascular Patient Who COVID-19 Infection Acute coronary syndrome, Cardiac arrest, Coronavirus disease 19 infection, Heart arrhythmia, Myocarditis transthoracic echocardiography alone, ultrasound alone Hamad Medical Corp Qatar 2020-06-02 2020-12-31 MRC-05-113, NCT04430374 Phase Not Applicable Recruiting 1 6 Months 100 DR.Jassim Alsuwaidi Senior Consultant, Dr.Jassim Alsuwaidi Senior Consultant, MRC 2020-06-16
COVIpreg-UK: Studying the immune response and long-term morbidity of COVID-19 infection in pregnancy Coronavirus disease 19 infection Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Queen Mary University of London February Foundation UK 2020-05-07 2022-06-06 COVIpreg-UK, IRAS 283699, ISRCTN93266696 Phase Not Applicable Recruiting 1 25 Months 200 Dr Dodds, Dr Stamatina Iliodromiti 2020-06-16
A phase III trial of Inactivated vaccine (COVID-19), Sinovac Biotech for COVID-19 Coronavirus disease 19 infection Inactivated vaccine (COVID-19), Sinovac Biotech alone Instituto Butantan, Sinovac Biotech Ltd Brazil Phase 3 Clinical Status not specified 1 2020-06-16
CELMA: Safety and Efficacy of Mesenchymal Stem Cells in the Management of Severe COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia Umbilical cord derived mesenchymal stem cells alone, Usual treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Trustem Fundación Universitaria de Ciencias de la Salud, Hospital Infantil Universitario de San Jose, Hospital de San Jose 2020-07-31 2020-11-30 202001, CELMA, NCT04429763 Phase 2 Clinical Not yet recruiting 0 4 Months 30 Carlos Escobar-Soto, MD, PhD, Carolina Araque, MD, Esp, Guillermo Sánchez-Vanegas, MD, PhD, Jhon Jaime Sprockel Díaz, MD, Esp 2020-06-15
Safety of TY-027, a Treatment for COVID-19, in Humans Coronavirus disease 19 infection TY-027, Tychan alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Tychan Pte Ltd Singapore 2020-06-09 2021-01-31 NCT04429529, SCT-001 Phase 1 Clinical Recruiting 1 7 Months 25 Anjali Baglody, MSc, Bo Hong Tay, Jenny Low, MBBS, Justin Ng, PhD, Shayne Lin 2020-06-15
LCECS: Development and Application of a Low-Cost Ear-Contactless Stethoscope Powered by Raspberry Pi and Python Coronavirus disease 19 infection Low-Cost Ear-Contactless Stethoscope alone Healthy volunteers accepted Shengjing Hospital of China Medical University China 2020-06-12 2021-06-12 ChiCTR2000033830, LCECS Phase Not Applicable Not yet recruiting 1 12 Months 12 Chuan Yang 2020-06-16
A phase III clinical study of SARS-CoV-2 vaccine, Ad26.COV2-S for the treatment of COVID-19 Coronavirus disease 19 infection SARS-CoV-2 recombinant adenoviral vector vaccine (AdVac/PER.C6, COVID-19), Johnson & Johnson/Biomedical Advanced Research and Development Authority/Beth Israel Deaconess Medical Center alone Johnson & Johnson Phase 3 Clinical Planned 0 2020-06-15
COMETE-19: Covid-19 at the Regional Medical Center Metz-Thionville: a Descriptive Study Coronavirus disease 19 infection Centre Hospitalier Régional Metz-Thionville France 2020-03-01 2021-06-30 2020-02OBS-CHRMT, COMETE-19, NCT04430322 Phase Not Applicable Recruiting 1 16 Months 330 Nadia OUAMARA, Rostane GACI, MD, Vincent DINOT 2020-06-15
Hydroxychloroquine Use in Hospitalized Patients With COVID-19: Impact on Progression to Severe or Critical Disease Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) WellStar Health System US 2020-05-07 2020-12-07 1604885, NCT04429867 Phase 4 Clinical No longer recruiting 1 7 Months 700 2020-06-15
OpMiCoV: Explorative Study of the Association of Oropharyngeal Microbiota Profiles with SARS-CoV-2 Infection and COVID-19 disease Coronavirus disease 19 infection, Upper respiratory tract infection, Viral pneumonia Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Deutsches Krebsforschungszentrum Germany 2020-04-02 DRKS00021424, OpMiCoV, S-194/2020, U1111-1253-4873 Phase Not Applicable No longer recruiting 1 360 Christoph Stein-Thoeringer 2020-06-15
Epidemiological and Demographic Data From 150 Patients Diagnosed With Coronavirus Disease 2019 Pneumonia Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Etfal Hospital Turkey 2020-05-15 2020-06-05 DM3334, NCT04430023 Phase Not Applicable Completed 1 150 ayse cinar 2020-06-15
Health Professional Exposure Assessment to Covid-19 (SERODRON) Coronavirus disease 19 infection RT-PCR test alone, blood sampling alone, serological test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier de Tourcoing France 2020-06-30 2020-12-31 NCT04429724, RIPH_2020_8 Phase Not Applicable Not yet recruiting 3 6 Months 6000 Pierre PATOZ, PharmD, SIVERY, Solange TREHOUX, PhD, VACHEE 2020-06-15
MAGIC: Impact of Smoking and Nicotine on the Risk of Being Infected With COVID-19 Coronavirus disease 19 infection, Nicotine dependence nicotine substitute therapy alone, serological test alone, smoking cessation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France France 2020-07-01 2021-04-01 2020-A01681-38, MAGIC, NCT04429815 Phase Not Applicable Not yet recruiting 1 9 Months 489 Christian Rabaud 2020-06-16
A study to predict the disease progression in COVID-19 patients by analyzing blood samples of these patients from using high-throughput mass spectrometry platform Coronavirus disease 19 infection high-throughput mass spectrometry alone Charite Universitaetsmedizin Berlin The Francis Crick Institute UK Phase Not Applicable Status not specified 1 31 Prof. Dr. Markus Ralser 2020-06-15
A phase I clinical study to assess TP-508 in the treatment of patients with COVID-19 Coronavirus disease 19 infection rusalatide alone Factor IIa modulator Chrysalis BioTechnology Inc National Institute of Allergy and Infectious Diseases Phase 1 Clinical Planned 0 2020-06-15
Follow-up of COVID-19 Positive Patients Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bangladesh Health Professions Institute Bangladesh 2020-06-23 CTRI/2020/06/025857 Phase Not Applicable Not yet recruiting 1 200 K M Amran Hossain, Md. Obaidul Haque 2020-06-16
SARS-CoV2 IIF: Prospective Assay for SARS-CoV-2 Antibody Detection Indirectly by Immunofluorescence Coronavirus disease 19 infection SARS-CoV2 ELISA alone, immunofluorescence (SARS-CoV2 IIF ) alone, qPCR assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Szeged Biological Research Center of the Hungarian Academy of Sciences Hungary 2020-05-30 2020-12-31 NCT04429620, SARS-COV-2-IIF-002, SARS-CoV2 IIF Phase Not Applicable Recruiting 1 7 Months 100 Dávid Pintér, Pharm. D., Katalin Burián, MD 2020-06-16
A phase II clinical study to assess TP-508 in the treatment of patients with COVID-19 Coronavirus disease 19 infection rusalatide alone Factor IIa modulator Chrysalis BioTechnology Inc, National Institute of Allergy and Infectious Diseases Phase 2 Clinical Planned 0 2020-06-15
Evaluation of siddha regimen in the management of covid 19 Coronavirus disease 19 infection Variable regimens including Adathodai Manapagu , Kabasura kudineer , Thippili Rasayanam , Vasantha kusumakaram Mathirai Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Government Siddha Medical College India 2020-06-25 CTRI/2020/06/025856 Phase 2 Clinical Not yet recruiting 1 Dr N Anbu, Dr S M Chitra 2020-06-16
A retrospective, cohort, uncontrolled, exploratory study to evaluate the effects of treatment with interferon-alpha2b in the confirmed COVID-19 patients in Wuhan, China Coronavirus disease 19 infection interferon alpha-2b (COVID-19, inhaled), Altum Pharmaceuticals alone, arbidol plus interferon alpha-2b (COVID-19, inhaled), Altum Pharmaceuticals Interferon alpha ligand modulator Union Hospital Tongji Medical School Huazhong University Of Science & Technology China Phase Not Applicable Status not specified 1 77 2020-06-15
Effect of AYUSH 64 in COVID 19 Coronavirus disease 19 infection AYUSH 64 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Institute for Post Graduate Teaching and Research in Ayurveda India 2020-06-15 CTRI/2020/06/025855 Phase 2 Clinical Not yet recruiting 2 200 Dr Mandip Goyal, Dr Sagar M Bhinde, Dr Yagnik Chotala, Prof Anup Thakar 2020-06-15
Serum protein marker in patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Healthy volunteers accepted, Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Chongqing People'S Hospital China 2020-02-01 2022-02-01 ChiCTR2000033872 Phase 0 Clinical No longer recruiting 1 24 Months 350 Ling Yan, Pu Liao 2020-06-16
Efficacy, Safety, Tolerability, and Biomarkers of MN-166 (Ibudilast) in Patients Hospitalized With COVID-19 and at Risk for ARDS Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia ibudilast (oral, neuropathic pain/opiate dependence/neurodegeneration/TBI/drug dependence/acute respiratory distress syndrome/COVID-19), MediciNova alone IL-6 receptor antagonist, Interleukin-1 beta ligand inhibitor, Macrophage migration inhibitory factor inhibitor, PDE 10 inhibitor, PDE 4 inhibitor, TLR-4 antagonist, TNF alpha ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) MediciNova Inc, Yale School of Medicine US 2020-07-31 2021-12-01 MN-166-COVID-19-201, NCT04429555 Phase 2 Clinical Not yet recruiting 1 16 Months 40 Dr. Geoffrey Chupp, Dr. Insoo Kang, Joanna Dojillo, MMsc, Kazuko Matsuda, MD PhD MPH, r. Maor Sauler 2020-06-16
A pilot study of baricitinib for treatment of bilateral COVID-19 pneumonia Coronavirus disease 19 infection, Viral pneumonia baricitinib alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Eli Lilly & Co, Imperial College London Italy Phase 2 Clinical Status not specified 1 4 2020-06-15
The efficacy and safety of convalescent plasma therapy in novel coronavirus pneumonia (COVID-19): A medical records based retrospective, cohort study Coronavirus disease 19 infection, Viral pneumonia convalescent plasma therap alone, non-convalescent plasma therapy alone Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tongji Hospital, Huazhong University of Science and Technology China 2020-06-12 2021-06-11 ChiCTR2000033798 Phase Not Applicable Not yet recruiting 1 12 Months 150 Minghao Fang, Yi Bian 2020-06-16
Cerebral Compliance Impairment in COVID-19 Brain disease, Coronavirus disease 19 infection Brain4care (B4C) sensor alone, Transcranial Doppler alone Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Sao Paulo Brazil 2020-05-01 2020-07-31 31750820.1.0000.0068, NCT04429477 Phase Not Applicable Recruiting 1 3 Months 50 Gustavo Frigieri, PhD, Sergio Brasil, MD, Sergio Brasil, PhD 2020-06-16
DAWN-Plasma: Donated Antibodies Working Against nCoV Coronavirus disease 19 infection, Lower respiratory tract infection, Upper respiratory tract inflammation Convalescent plasma alone, Standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitaire Ziekenhuizen Leuven Federal Knowledge Centre (KCE) Belgium 2020-05-02 2021-11-02 DAWN-Plasma, NCT04429854, S63992 Phase 2 Clinical Recruiting 14 18 Months 483 Bernard Bouckaert, MD, Clotilde Visée, MD, Geert Meyfroidt, MD, PhD, Georgala Aspasia, MD, Jean Yombi, MD, Laurent Jadot, MD, Lucie Seyler, MD, Matthias Leys, MD, Michel Moutschen, MD, Nicolas Dauby, MD, Niels Van Regenmortel, MD, Timothy Devos, MD,PHD 2020-06-16
A phase II clinical study of self-amplifying RNA vaccine (im, COVID-19), Imperial College London for the potential prevention of SARS-CoV-2 infection (COVID-19) Coronavirus disease 19 infection self-amplifying RNA vaccine (im, COVID-19), Imperial College London alone COVID19 Spike glycoprotein inhibitor Imperial College London UK Government 2020-06-30 Phase 2 Clinical Planned 0 2020-06-15
CGM-ISO: Remote Continues Glucose Monitoring During the COVID-19 Pandemic in Quarantined Hospitalized Patients Coronavirus disease 19 infection, Diabetes mellitus, Viral pneumonia CGM stratification alone, Dexcom G6 alone, Standard care with fingerprick glucose test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nordsjaellands Hospital Denmark 2020-05-25 2021-05-25 CGM-ISO, H-20025305, NCT04430608 Phase Not Applicable Recruiting 1 12 Months 72 Carina Klarskov, MD, Peter L. Kristensen, MD, ph.D 2020-06-16
HAD-Covid: Impact of Covid-19 Restrictive Measure on Anxiety, Depression and PTSD for Relatives of ICU Patients Anxiety disorder, Coronavirus disease 19 infection, Depression, Post traumatic stress disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Clermont-Ferrand France 2020-06-22 2022-01-22 2020 HAD-COVID, HAD-Covid, NCT04430049 Phase Not Applicable Not yet recruiting 11 19 Months 120 Alexandre Lautrette, MD, PhD, Anne Médard, MD, Arnaud Delahaye, MD, Christophe Leroy, MD, Edouard Soum, MD, Emmanuel Futier, MD,PhD, Jean-Etienne Bazin, MD, PhD, Lise Laclautre, Luc Jarrige, MD, Marie-Hélène Hausermann, MD, Nathanael Einsemann, Pierre-Marie Bertrand, MD, Ramin Ravan, MD, Russel Chabanne, MD, Sophie Cayot, MD, Thierry Gillard, MD 2020-06-16
COV003: A phase III study to investigate a vaccine against COVID-19 Coronavirus disease 19 infection AZD-1222 alone, AZD-1222 plus paracetamol COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Federal University of Sao Paulo, University of Oxford The Lemann Foundation Brazil 2020-05-01 2021-07-31 COV003, COV003, ISRCTN89951424 Phase 3 Clinical Recruiting 1 15 Months 2000 Dr Peter O'Reilly 2020-06-16
CATALYST: An adaptive, multi-arm, multi-stage clinical trial to evaluate the efficacy of IZN-101 and CT-P13 in the treatment of hospitalized patients with severe COVID-19 infection Coronavirus disease 19 infection infliximab biosimilar, Celltrion/Nippon Kayaku/Hospira/Orion/EGIS Gyogyszergyar alone, namilumab alone GM-CSF ligand inhibitor, TNF alpha ligand inhibitor, TNF binding agent NIHR Birmingham Biomedical Research Centre, The University of Birmingham, University Hospital Birmingham NHS Foundation Trust NIHR Biomedical Research Centre, Oxford, United Kingdom Research & Innovation, University College London, University of Oxford US CATALYST Phase Not Applicable Recruiting 1 Dr Ben Fisher, Dr Matt Rowland, Professor Duncan Richards 2020-06-15
A placebo-controlled trial to evaluate REGN-CoV2 for the prevention of COVID-19 in uninfected people with close exposure to a COVID-19 patient Coronavirus disease 19 infection REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Regeneron Pharmaceuticals Inc US 2020-06-11 Phase Not Applicable Recruiting 1 Dr. Suraj Saggar 2020-06-15
A placebo-controlled trial to evaluate REGN-CoV2 for the prevention of COVID-19 in uninfected people who are at high-risk of exposure Coronavirus disease 19 infection REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Regeneron Pharmaceuticals Inc US 2020-06-11 Phase Not Applicable Recruiting 1 Dr. Suraj Saggar 2020-06-15
ERNA: An intensive, longitudinal study on habit formation of hand washing behavior during the COVID-19 pandemic Coronavirus disease 19 infection hand washing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical School Berlin Berlin Free University Germany 2020-06-25 DRKS00022067, ERNA, MSB-2020/36 Phase Not Applicable Not yet recruiting 5 134 Antonia Domke, Lena Fleig 2020-06-15
Ivermectin versus Placebo for the Treatment of Patients With Mild to Moderate COVID-19 Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sheba Medical Center Israel 2020-05-12 2020-10-31 NCT04429711, SHEBA-20-7156-ES-CTIL Phase 2 Clinical Recruiting 1 5 Months 100 Asaf Biber, Dr., Eli Schwartz, M.D, Eli Schwartz, Prof., Prof. Eli Schwartz MD, DTMH 2020-06-16
A clincial study to assess immune response of QuadraMune in healthy subjects for the prevention of COVID-19 Coronavirus disease 19 infection QuadraMune alone Healthy volunteers accepted Therapeutics Solutions International Inc Phase Not Applicable Status not specified 0 8 Dr. James Veltmeyer 2020-06-15
Multicenter, adaptive, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of the drug ХС-221, 100 mg tablets, in patients with COVID-19 Coronavirus disease 19 infection XC-221 alone RSV Therapeutics LLC Russian Federation 2020-06-09 2021-12-31 ХС221-03-02-2020 Phase 3 Clinical Status not specified 7 18 Months 150 2020-06-15
Post-traumatic Stress Disease in Health Workers During COVID-19 Pandemia Coronavirus disease 19 infection, Post traumatic stress disorder Maslach Burnout Inventory (MBI) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) IRCCS AOU San Martino – IST Italy 2020-03-01 2020-07-01 NCT04424771, PTSD-COVID-19 Phase Not Applicable Recruiting 2 4 Months 800 Eleonora Giuntoli, MD, Eleonora Guaitoli, Eleonora Guaitoli, MD, Fabio Barra, Fabio Barra, MD 2020-06-15
AKI C19 HKL: Acute kidney injury and renal replacement therapy: incidence and outcome in COVID-19 patients admitted to Hospital Kuala Lumpur Coronavirus disease 19 infection, Renal injury renal replacement therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Kuala Lumpur Malaysia 2020-06-15 2021-12-31 55036, AKI C19 HKL, AKI C19 HKL, NMRR-20-1090-55036 Phase Not Applicable Not yet recruiting 1 18 Months 371 Dr NURUL ZAYNAH BINTI NORDIN 2020-06-15
A Study of LY-3819253 (LY-CoV555) in Participants With Early Mild-to-Moderate COVID-19 Illness Coronavirus disease 19 infection LY-CoV555 alone COVID19 Spike glycoprotein modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eli Lilly & Co AbCellera Biologics Inc US 2020-06-13 2020-09-15 17947, J2W-MC-PYAB, NCT04427501 Phase 2 Clinical Not yet recruiting 17 3 Months 400 A Blomkalns, B Heller, C Malvestutto, D Pitrak, E Kaufman West, G J Criner, I J Shawa, J Glassberg, K Highland, M L Dougan, M Ramesh, P Chen, P Milligan, R Gottlieb, V Stosor, W A Fischer 2020-06-15
IDEA: Ivermectin, Aspirin, Dexametasone and Enoxaparin as Treatment of COVID-19 Coronavirus disease 19 infection, Viral pneumonia Variable regimens including aspirin , dexamethasone , enoxaparin sodium , ivermectin Chloride channel modulator, Low molecular weight heparin Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eurnekian Public Hospital Argentina 2020-05-01 2020-07-30 IDEA, IDEA, NCT04425863 Phase Not Applicable No longer recruiting 1 2 Months 10 Alfredo Secchi, M.D., Hector E Carvallo 2020-06-16
To Compare Videolaryngoscope Against Direct Laryngoscope for Intubation When Powered Air Purifying Respirator is Worn Anesthesia, Coronavirus disease 19 infection McGrath videolaryngoscope alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Singapore General Hospital Pte Ltd Duke-NUS Graduate Medical School Singapore 2020-06-01 2020-12-31 2020/2329, NCT04424953 Phase Not Applicable Not yet recruiting 1 7 Months 60 Qing Yuan Goh, M.Med (Anes), Zihui Tan, M.Med (Anes) 2020-06-16
Efficacy of Convalescent Plasma Therapy in Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Convalescent Plasma therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institute of Liver and Biliary Sciences, India India 2020-06-09 2021-05-30 ILBS-COVID-04, NCT04425915 Phase 3 Clinical Recruiting 3 11 Months 400 Dr Ankit Bhardwaj, Masters-CT, Dr Meenu Bajpai, MD, Dr Suresh Kumar, MD, Dr Vikas Dogra, MD 2020-06-15
Thorax Computed Tomography Severity Score and Outcome in COVID-19 Patients Coronavirus disease 19 infection, Viral pneumonia CT scan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tepecik Training and Research Hospital Turkey 2020-03-15 2020-07-15 2020/5-4, NCT04424849 Phase Not Applicable Recruiting 1 4 Months 40 Aykut Sarıtaş, Isıl K Guldogan, Işıl Köse Güldoğan, Kazim Rollas, Kazım Rollas, Naciye Sinem GEZER, Nimet Şenoğlu, Taner Çalışkan, Uğur Uzun, Yeliz Pekçevik, Çiler Zincircioğlu, İsa Sahar 2020-06-15
Cardiovascular Risk Factors and Severe COVID-19. A Nationwide, Registry-based, Case-control Study Cardiovascular disease, Coronavirus disease 19 infection, Hypertension, Non-insulin dependent diabetes, Obesity antidiabetic therapy alone, antihypertensive agent therapy alone, statin therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Karolinska Institutet Sweden 2020-03-01 2022-12-31 4, NCT04426084 Phase Not Applicable No longer recruiting 1 34 Months 22784 Per Svensson 2020-06-15
AiM Covid Self Monitoring Coronavirus disease 19 infection AiM Covid App alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aarogyam UK Mothers Touch Foundation, NMP Medical Research Institute, Warwick University India 2020-04-12 2020-05-28 AU015, NCT04425044 Phase Not Applicable Completed 2 1 Month 1000 Vishwes Kulkarni 2020-06-15
Thymosin Alpha 1 to Prevent COVID-19 Infection in Elderly Renal Dialysis Patients Coronavirus disease 19 infection thymalfasin alone Thymosin receptor agonist Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Inova Health Care Services DaVita Clinical Research, Nephrology Associates of Northern Virginia, Inc. US 2020-06-30 2021-06-30 ACW-1221958-1, NCT04428008 Phase 0 Clinical Not yet recruiting 1 12 Months 240 William B Ershler, MD, William B. Ershler 2020-06-15
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Study Evaluating Favipiravir in Treatment of COVID-19 Coronavirus disease 19 infection, Viral pneumonia favipiravir alone, supportive care alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Zhejiang Hisun Pharmaceutical Co Ltd Opera CRO Romania, Germany, China 2020-06-30 2020-09-30 HS216C17(MRCT), NCT04425460 Phase 3 Clinical Not yet recruiting 8 3 Months 256 Dionisio Barattini, MD Europe, Opera CRO, Emanuel Dogaru, CPM, Opera CRO 2020-06-16
COVID-19 ORL: Smell and Taste Disorders in COVID-19 Patients Coronavirus disease 19 infection, Taste disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-05-15 2020-09-30 COVID-19 ORL, COVID-19 ORL, NCT04427332 Phase Not Applicable Recruiting 1 4 Months 500 Dante Jean Garavello Werner Jean, Prof., Dante Jean Garavello Werner, Professor 2020-06-16
COVID_OFF: Detection of SARS-CoV-2 in Follicular Fluid and Cumulus-oocyte-complexes in COVID-19 Patients Coronavirus disease 19 infection Endometrial biopsy alone Female, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) CRG UZ Brussel Belgium 2020-06-15 2021-06-15 COVIDOFF001, COVID_OFF, NCT04425317 Phase Not Applicable Not yet recruiting 1 12 Months 20 Elsie Nulens, Liese Boudry, Liese Boudry, MD 2020-06-16
Masq-Aute: Evaluation of ARFC Masks Equipped With CF5 Filter in the Care Unit to Allow a Wider Distribution of FFP2 Masks (Covid-19) Coronavirus disease 19 infection ARFC mask alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Saint Etienne France 2020-04-29 2020-06-30 2020-A00817-32, 20CH073, Masq-Aute, NCT04427176 Phase Not Applicable Recruiting 1 2 Months 30 Andréa BUCHMULLER, MD, Bernard TARDY, MD PhD, Florence RANCON, CRA, Jean Luc PERROT, MD PhD, Jean-Luc PERROT, MD PhD 2020-06-15
TOLD: Trial of Open-Label Dipyridamole In Hospitalized Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure, Respiratory tract infection dipyridamole alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) UConn Health US 2020-05-03 2021-05-30 20-192-2.F, NCT04424901, TOLD Phase 2 Clinical Recruiting 1 12 Months 100 Bruce Liang, MD, Christopher Pickett, MD, Elizabeth Laska, RN, Eric Mortensen, MD, Jeffrey Aeschlimann, PharmD, Kevin Dieckhaus, MD, Mark Metersky, MD, Patti Keltonic, RN 2020-06-15
A phase Ia/Ib clinical trial of trans sodium crocetinate for the treatment of hospitalized COVID-19 patients displaying severe respiratory symptoms and low oxygen levels Coronavirus disease 19 infection trans sodium crocetinate alone ARENSIA Exploratory Medicine, Diffusion Pharmaceuticals LLC Romania 2020-06-30 Phase 1 Clinical Planned 1 Prof. Adrian Streinu-Cercel 2020-06-12
Vitamin A and COVID-19 Coronavirus disease 19 infection vitamin A alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Iran University of Medical Sciences Iran 2020-05-21 IR.IUMS.REC.1399.204, IRCT20200405046951N1 Phase 3 Clinical Recruiting 1 120 Azadeh Mottaghi 2020-06-15
Evaluation the effect of raltegravir and raltegravir/interferon beta combination on COVID-19 patients Coronavirus disease 19 infection Variable regimens including hydroxychloroquine , interferon beta , raltegravir HIV-1 integrase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jahrom University of Medical Iran 2020-06-19 IR.JUMS.REC.1399.028, IRCT20200412047042N1 Phase 3 Clinical Not yet recruiting 1 60 Dr Kavous Solhjoo, Dr Rahim Raoufi, ِDr Samaneh Zolghadri 2020-06-15
Assessment of Thermal Condition of Health Workers Who Use Personal Protective Equipment From Biological Hazards During Their Work With COVID-19 Patients Coronavirus disease 19 infection Personal protective equipment alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Federal State Budgetary Scientific Institution 'Izmerov Research Institute of Occupational Health' Russian Federation 2020-06-03 2020-06-10 NCT04427267, PPE-02 Phase Not Applicable Recruiting 1 6 Andrey Geregey, Konyukhov Alexey, Laboratory of PPE and industrial exoskeletons, Lemeshko Vladislav, PPE-lab 2020-06-15
VENTED COVID: Low Dose Whole Lung Radiation Therapy for Patients With COVID-19 and Respiratory Compromise Coronavirus disease 19 infection, Hypoxia, Lung inflammation, Respiratory disease, Viral pneumonia ultralow dose-whole lung radiation therapy (80 cGy) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ohio State University Comprehensive Cancer Center US 2020-06-30 2021-12-31 NCT04427566, VENTED, VENTED COVID Phase 2 Clinical Not yet recruiting 1 18 Months 24 Arnab Chakravarti, Kimberly Mahler 2020-06-12
VExCO: Mechanical ventilator for use in patients with respiratory failure due to Covid-19 Coronavirus disease 19 infection, Respiratory failure ventilator alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro Foundation for Research Financial Support in the State of Rio de Janeiro (FAPERJ) Brazil 2020-06-04 2020-06-11 4.063.224, CAAE: 31031920.2.0000.5257, RBR-2dxyx4, U1111-1252-8144, VExCO Phase Not Applicable Not yet recruiting 1 5 Diamantino Ribeiro Salgado 2020-06-16
HFNC Treatment in COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia high flow nasal cannula device alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Hamidiye Etfal Training and Research Hospital Turkey 2020-05-15 2020-06-05 5569, NCT04424836 Phase Not Applicable Recruiting 1 40 ayse su cinar, mustafa altinay, mustafa altınay, nebia peker 2020-06-16
Therapeutic Vaccine Trial of COVID-19 for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Coronavirus disease 19 infection Covax-19 alone Coronavirus spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Genecure LLC 2020-07-31 2021-12-31 GC004, NCT04428073 Phase 1 Clinical Not yet recruiting 0 17 Months 32 Frank Tung, Ph.D 2020-06-16
Identification of Genetic Factors Determining Disease Course in the New Type of Coronavirus Infection, COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Szeged Hungary 2020-06-05 2021-07-31 COVID19_HUNGEN_001, NCT04426253 Phase Not Applicable No longer recruiting 11 13 Months 1000 Márta Széll, MD, Ph.D. 2020-06-15
Chloroquine + Losartan Compared to Chloroquine Alone for the Treatment of COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia chloroquine phosphate plus losartan Angiotensin II AT-1 receptor antagonist, Angiotensin II receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario Dr. Jose E. Gonzalez Mexico 2020-03-10 2020-08-30 IF20-00003, NCT04428268 Phase 2 Clinical Recruiting 1 5 Months 20 Adrian Camacho Ortiz, MD, Adrian Camacho, PhD, Adrian Camacho-Ortiz, PhD, Eduardo Pérez Alba, MD, Juan Diego Lecona García, MD, Laura Marina Nuzzolo Shihadeh, MD 2020-06-15
Autologous Adipose-derived Stem Cells (AdMSCs) for COVID-19 Coronavirus disease 19 infection AdMSCs (osteoarthritis/rheumatoid arthritis), CelltexTherapeutics alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Celltex Therapeutics Corp US 2020-06-20 2021-08-10 CTX0020-003, NCT04428801 Phase 2 Clinical Not yet recruiting 1 13 Months 200 Candy Eller, Derek W Guillory, MD. 2020-06-13
SERO-MARES: Prevalence and Risk Factors of SARS-CoV-2 Antibody Responses Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital de Mataró Spain 2020-06-08 2021-06-30 NCT04425759, SERO-MARES, SERO-MARES (56/20) Phase Not Applicable Recruiting 2 12 Months 2400 Pere Clavé, MD, Pere Clavé, MD, PhD 2020-06-15
IVERCAR: Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 Coronavirus disease 19 infection Ivercass (ivermectin) alone, iota carrageenan application alone, personal protective equipment usage alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eurnekian Public Hospital Argentina 2020-06-01 2020-08-30 IVERCAR, IVERCAR, NCT04425850 Phase Not Applicable Recruiting 1 2 Months 70 Hector E Carvallo, Hector E Carvallo, M.D., Roberto R Hirsch, M.D. 2020-06-15
BIG-C: Exploring Interventions for Glue Ear During Covid-19 Coronavirus disease 19 infection, Hearing loss, Otitis media Hear Glue Ear app (Cambridgeshire Community Services NHS Trust) alone, bone conduction headphone alone, microphone alone, telephone consultation alone, video consultation alone Preschool Children (2-5 yrs), Children (6-12 yrs) Cambridgeshire Community Services NHS Trust Cambridge University Hospitals NHS Foundation Trust UK 2020-06-22 2021-06-01 262816, BIG-C, NCT04427631 Phase Not Applicable Not yet recruiting 1 11 Months 20 Alison Sansome, BM BCh MA MRCPCH, Dr. Tamsin Brown, Tamsin M Holland Brown, MBBS MRCPCH, alison Sansome, MBBS MRCPCH 2020-06-15
The efficacy of barely-based traditional remedy on COVID-19 Coronavirus disease 19 infection Variable regimens including atazanavir + ritonavir , barley-based remedy , chloroquine phosphate , hydroxychloroquine , lopinavir + ritonavir HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University Iran 2020-05-13 IR.SBMU.RETECH.REC.1399.074, IRCT20180923041093N6 Phase 3 Clinical Recruiting 1 60 Mahmood Khodadoost, Roshanak Mokaberinejad 2020-06-15
COV-OB-ICU: Obesity and Mortality of Critically Ill Patients With COVID-19 Coronavirus disease 19 infection, Obesity, Respiratory failure, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France France 2020-05-12 2020-05-26 2020PI082, COV-OB-ICU, NCT04425213 Phase Not Applicable Completed 1 250 Olivier Ziegler, PU-PH 2020-06-15
Use of Remote Monitoring for COVID-19 Patient Coronavirus disease 19 infection LifeSignals Biosensor 1AX alone, Remote Patient Monitoring alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Montefiore Medical Center US 2020-06-05 2021-06-01 NCT04425720, PENDING Phase Not Applicable Not yet recruiting 1 11 Months 300 Jonathan Leff, MD, Singh Nair, PhD 2020-06-15
Early Prone Position on Coronavirus Disease 2019 Pneumonia (Prone Position) Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia conventional oxygen therapy alone, prone position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Etfal Hospital Turkey 2020-06-05 2020-06-15 NCT04427969, PP34 Phase Not Applicable Recruiting 1 40 ayse surhan cinar, mustafa altinay, nebia peker 2020-06-15
MI-COVID: Predictive Factors COVID-19 Patients Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-03-01 2021-05-31 MI-COVID, MI-COVID, NCT04427345 Phase Not Applicable Recruiting 1 15 Months 1000 Paolo Bonfanti, Paolo Bonfanti, Professor 2020-06-15
Evaluation of Saliva/Nares as Source of Detection for SARS-CoV-2 at NIH Coronavirus disease 19 infection COVID-19 screening alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institutes of Health Clinical Center US 2020-06-17 2021-06-01 20-CC-0128, 200128, NCT04424446 Phase Not Applicable Recruiting 1 11 Months 5000 Karen M Frank, M.D., Rebecca A Nebel, Ph.D. 2020-06-16
COVID-19 Antibodies Among Healthcare Workers Coronavirus disease 19 infection COVID-19 IgG/IgM rapid test Cassette test (Healgen Scientific, Houston, Texas, USA) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario Dr. Jose E. Gonzalez Mexico 2020-05-05 2020-06-01 IF20-00008, NCT04425889 Phase Not Applicable Completed 1 156 Dr. Adrian Camacho-Ortiz 2020-06-15
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19 Coronavirus disease 19 infection Face mask alone, High-intensity oxygen therapy alone, Low-flow oxygen therapy alone, Mechanical ventilation alone, Nasal cannula alone, REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Regeneron Pharmaceuticals Inc US 2020-06-12 2021-03-03 NCT04426695, R10933-10987-COV-2066 Phase 1/Phase 2 Clinical Recruiting 1 8 Months 1860 Clinical Trial Management, Clinical Trials Administrator, Dr. Suraj Saggar 2020-06-15
DOLCI: Darunavir/Cobicistat versus Lopinavir/Ritonavir in COVID-19 Pneumonia in Qatar Coronavirus disease 19 infection, Viral pneumonia darunavir + cobicistat (fixed dose, HIV infection), Janssen R&D/ Gilead alone, lopinavir + ritonavir alone Cytochrome P450 3 inhibitor, HIV protease inhibitor, HIV-1 protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hamad Medical Corp Qatar 2020-03-01 2020-09-30 DOLCI, MRC-05-069, NCT04425382 Phase Not Applicable Recruiting 1 7 Months 200 Dr. Eman Elmekaty, PharmD 2020-06-15
A phase I trial of SARS-CoV-2 virus-neutralizing mAbs (COVID-19), AstraZeneca/ VUMC for SARS-CoV-2 virus Coronavirus disease 19 infection SARS-CoV-2 virus-neutralizing mAbs (COVID-19), AstraZeneca/ VUMC alone AstraZeneca plc US Department of Defense, Vanderbilt University Phase 1 Clinical Planned 0 2020-06-12
INHIXACOV19: Enoxaparin in COVID-19 Moderate-to-Severe Hospitalized Patients Coronavirus disease 19 infection, Multiple organ failure, Respiratory failure, Septic shock, Thrombosis, Viral pneumonia enoxaparin sodium biosimilar, Techdow alone, standard thromboprophylaxis alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Policlinico S.Orsola-Malpighi Italy 2020-05-22 2020-10-30 2020-001308-40, INHIXACOV19, NCT04427098 Phase 2 Clinical Recruiting 13 5 Months 300 Andrea Romagnoli, MD, Antonella Castagna, MD, Aria Patacca, MD, Arturo Montineri, MD, Elena Giovanna Bignami, MD, Elvira Grandone, MD, Evelina Tacconelli, MD, Francesco Cristini, MD, Fulvia Mazzaferri, MD, Giovanni Di Perri, MD, Giulio De Stefano, MD, Maddalena Giannella, MD, Marco Baciarello, MD, Marco Mangiafico, MD, Massimo Salvetti, MD, Pierluigi Viale, MD, Raffaello Bellosta, MD, Renzo Rossini, MD, Salvatore Casari, Sophie Testa, MD, Stefano Bonorq, MD, Stefano Triscornia, BS 2020-06-15
COVID-19GAOM: RT-PCR SARS-CoV-2 at 1 Month of COVID-19 Infection in the Geriatric Population Coronavirus disease 19 infection RT-PCR SARS-CoV-2 test alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-05-07 2020-08-31 7838, COVID-19GAOM, NCT04427358 Phase Not Applicable Recruiting 1 3 Months 100 Maxence MEYER, MD, Saïd CHAYER, PhD, HDR 2020-06-15
STORM: The Natural History of Hospitalized COVID-19 Patients Coronavirus disease 19 infection, Inflammatory disease, Lung infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-02-23 2020-12-31 NCT04424992, STORM, STORM Phase Not Applicable No longer recruiting 1 10 Months 1433 2020-06-15
Accelerated LFR for Bipolar Patients During the COVID-19 Pandemic Bipolar I disorder, Bipolar II disorder, Coronavirus disease 19 infection Accelerated low-frequency right-sided stimulation protocol alone, B70 Fluid-Cooled Coil alone, MagPro X100 Stimulator alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre for Addiction and Mental Health Canada 2020-06-09 2022-12-31 071-2020, NCT04427137 Phase Not Applicable Recruiting 1 30 Months 50 Daniel Blumberger, MD, Dov Millstone, Hannah Taalman 2020-06-16
Utility of Lactoferrin as a Preventive Agent for Healthcare Workers Exposed to COVID-19 Coronavirus disease 19 infection lactoferrin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Cairo University Egypt 2020-07-31 2020-11-30 CUKA-002, NCT04427865 Phase 2/Phase 3 Clinical Not yet recruiting 1 4 Months 200 Gamal Esmat 2020-06-16
Core Warming of COVID-19 Patients Coronavirus disease 19 infection core warming alone, ensoETM device alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University in St Louis US 2020-06-30 2020-11-30 202005150, NCT04426344 Phase Not Applicable Not yet recruiting 1 5 Months 20 Anne Drewry, MD, Katie Dalton 2020-06-15
ILIAD-7-US-O: InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic patients With COVID-19 Infection Coronavirus disease 19 infection, Lymphocytopenia, Respiratory failure CYT-107 alone IL-7 receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Revimmune Inc Amarex Clinical Research, Memorial Sloan-Kettering Cancer Center US 2020-06-22 2020-12-31 ILIAD-7 COVID US ONCO, ILIAD-7-US-O, NCT04426201 Phase 2 Clinical Not yet recruiting 1 6 Months 48 Frederique Berbille, MHSc, Marcel van den Brink, MD, PhD, Michel MORRE, DVM, Steve Pastores, MD 2020-06-15
CRI-CP: Effectiveness and Safety of Convalescent Plasma in Patients With High-risk COVID-19 Coronavirus disease 19 infection, Multiple organ failure, Respiratory disease, Respiratory failure, Septic shock, Viral pneumonia convalescent plasma alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion Santa Fe De Bogota Colombia 2020-07-31 2021-02-28 CRI-CP, NCT04425837, PLASMA COVID-19 Phase 2/Phase 3 Clinical Not yet recruiting 1 7 Months 236 Guillermo E Quintero, Hematologist, Guillermo Enrique Quintero-Vega, José A De la Hoz, Epidemiologist, José De la Hoz, Epidemiologist 2020-06-15
Effect of Covid-19 Epidemic on Primary PCI in Patients With STEMI Coronavirus disease 19 infection, Myocardial infarction percutaneous coronary intervention (PCI) alone Beijing Friendship Hospital China 2019-01-24 2021-07-24 BFH-COVID-19 AND PRIMARY PCI, NCT04427735 Phase Not Applicable Recruiting 1 30 Months 200 Hongwei Li, Hongwei Li, MD, Hongwei Li, doctor, Xuhe Gong 2020-06-15
Ivermectin In Treatment of COVID-19 Patients Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ministry of Health and Population Egypt 2020-06-09 2020-09-01 14-2020/3, NCT04425707 Phase 2 Clinical Recruiting 1 2 Months 100 ehab ah kamal, MD, houssam ho masoud, MD, noha mo asem, MD 2020-06-15
COVEMUZ: SARS-COV-2 Seroprevalence and Seroconversion Among Employees of the Universitair Ziekenhuis Brussel During the 2020 COVID-19 Outbreak Coronavirus disease 19 infection blood sampling alone, questionnaire alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitair Ziekenhuis Brussel Belgium 2020-05-12 2021-05-12 COVEMUZ, COVEMUZ, NCT04426292 Phase Not Applicable Recruiting 1 12 Months 3500 Laurien De Greef, Nurse, Sabine Allard, MD 2020-06-15
HOT-COVID: Handling Oxygenation Targets in COVID-19 Coronavirus disease 19 infection, Hypoxia, Respiratory failure oxygen alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aalborg Universitetshospital Copenhagen Trial Unit, Rigshospitalet, Denmark Denmark 2020-08-01 2024-03-01 2017-000632-34, AAUH-ICU-03, HOT-COVID, NCT04425031 Phase 4 Clinical Not yet recruiting 1 43 Months 780 Bodil Steen Rasmussen, MD, PhD, Olav Lilleholt Schjørring, MD, PhD, Thomas Lass Klitgaard, MD 2020-06-15
CORONEVRAXE: Study of the Sars-Cov2 Neuroinvasiveness - COVID-19 Coronavirus disease 19 infection, Neurological disease cerebrospinal fluid sampling alone, meningeal and brain parenchyma biopsies alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fondation Ophtalmologique Adolf De Rothschild France 2020-06-30 2022-06-30 CORONEVRAXE, NCT04427254, PBN_2020_16 Phase Not Applicable Not yet recruiting 1 24 Months 500 Amélie YAVCHITZ, MD, Pierre BOURDILLON, MD 2020-06-15
PLACO-COVID: Standard or Convalescent Plasma in Patients With Recent Onset of COVID-19 Respiratory Failure Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure COVID-19 convalescent plasma alone, standard plasma alone, standard therapy protocol alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Ospedaliera Citta della Salute e della Scienza di Torino Italy 2020-06-15 2021-12-15 CS3/33, NCT04428021, PLACO-COVID Phase 2 Clinical Not yet recruiting 1 18 Months 180 Paola Maria Manzini 2020-06-15
CORhum: Morbimortality of Covid-19 in Patients With Chronic Inflammatory Rheumatism Treated With Immunosuppressants Coronavirus disease 19 infection, Rheumatoid arthritis, Spondylarthritis, Systemic lupus erythematosus questionnaire assesment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille France 2020-08-31 2020-12-31 2020-A01650-39, CORhum, EQ2020_04, NCT04426279 Phase Not Applicable Not yet recruiting 1 4 Months 1500 Jean-Guillaume Letarouilly, MD 2020-06-15
MK-5475 in Participants With Hypoxemia Due to COVID-19 Pneumonia Coronavirus disease 19 infection, Hypoxia, Viral pneumonia MK-5475 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Merck Sharp & Dohme Corp 2020-07-07 2020-11-10 2020-002062-14, 5475-009, MK-5475-009, NCT04425733 Phase 1 Clinical Not yet recruiting 0 4 Months 64 Medical Director 2020-06-15
CRISIS: Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome brequinar alone, standard of care alone Dehydrogenase inhibitor, Dihydroorotate dehydrogenase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clear Creek Bio, Inc US 2020-06-12 2020-10-31 CCB-CRISIS-01, CRISIS, NCT04425252 Phase 1/Phase 2 Clinical Not yet recruiting 3 4 Months 24 Barbara L Powers, Ph.D, Gerard J Criner, MD, James S Pope, MD, Karel Calero, MD, Samuel Pope, MD, Vikram Kumar, MD 2020-06-15
CARDS: Cancer: Rapid Diagnostics and Immune Assessment for SARS-CoV-2 (COVID-19) Advanced solid tumor, Coronavirus disease 19 infection, Lymphoma antigen lateral flow assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The Royal Marsden NHS Trust Mologic Ltd, NIHR Biomedical Research Centre, Oxford, St Georges University of London, The Royal Marsden Cancer Charity UK 2020-05-26 2021-04-30 20/NE/0139, CARDS, CCR 5287, NCT04427280 Phase Not Applicable Recruiting 1 11 Months 60 David Lau, MBBS FRACP, Shannon Kidd, Sheela Rao, MD FRCP, Sue Cromarty 2020-06-15
A multicenter, randomized, double-blind, parallel-arm, placebo-controlled, phase II/III clinical study to assess opaganib in patients hospitalized with severe SARS-CoV-2 infection and pneumonia Coronavirus disease 19 infection, Viral pneumonia opaganib alone, standard-of-care alone Dihydroceramide delta 4 desaturase inhibitor, Sphingosine kinase 2 inhibitor RedHill Biopharma Ltd Europe, Russian Federation Phase 2/Phase 3 Clinical Planned 1 270 2020-06-12
A Phase II Trial of Infliximab in Coronavirus Disease 2019 (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Variable regimens including Tylenol , diphenhydramine , infliximab , infliximab biosimilar, Samsung Bioepis/ Merck & Co , prednisone TNF alpha ligand inhibitor, TNF binding agent Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tufts Medical Center National Institutes of Health US 2020-06-01 2020-12-31 NCT04425538, STUDY00000564 Phase 2 Clinical Recruiting 1 7 Months 17 Christian Lawlor, Jaime Chisholm, Paul Mathew, MD 2020-06-15
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult Patients With COVID-19 Coronavirus disease 19 infection REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Regeneron Pharmaceuticals Inc US 2020-06-09 2020-11-21 NCT04425629, R10933-10987-COV-2067 Phase 1/Phase 2 Clinical Recruiting 1 5 Months 1054 Clinical Trial Management, Clinical Trials Administrator 2020-06-16
A randomized, placebo-controlled, phase III clinical trial to assess losmapimod the treatment of patients with COVID-19 Coronavirus disease 19 infection losmapimod alone Double homeobox protein 4 inhibitor, p38 MAP kinase alpha inhibitor, p38 MAP kinase beta inhibitor, p38 MAP kinase inhibitor Fulcrum Therapeutics Inc US Phase 3 Clinical Planned 1 2020-06-12
A study to evaluate the clinical characteristics and epidemiological trend of COVID-19 infected children with or without GI symptoms Coronavirus disease 19 infection The University of Hong Kong Wuhan medical care center for women and children Hong Kong Phase Not Applicable Status not specified 1 244 Dr Kenneth Wong Kak-yuen 2020-06-12
MRCS: 'Minority and Rural Health Coronavirus Study (MRCS)' to evaluate the impact of COVID-19 on racial minorities and underserved communities across the country Coronavirus disease 19 infection Centene Corp, National Minority Quality Forum (NMQF), Quest Diagnostics Inc US 2020-06-30 MRCS Phase Not Applicable Not yet recruiting 1 5000 Alan Morgan, Elizabeth Ofili, Gary Puckrein, Gloria Wilder, Latrice Landry, Richard Beswick, Salaheddin Mahmud, Suja M. Mathew, Thomas LaVeist, Vin Gupta, William A. Meyer 2020-06-12
DOD: A Multicenter, Randomized-Controlled trial to Assess the Safety and Efficacy of Seraph 100 Microbind Affinity Blood Filter (Seraph 100) in the treatment of critically-ill COVID-19 patients Coronavirus disease 19 infection Seraph 100 Microbind Affinity Blood Filter alone ExThera Medical LLC US Department of Defense US, Europe DOD Phase Not Applicable Planned 2 2020-06-11
An multi-national multicenter clinical trial of YS-SC2-010 for the treatment of Coronavirus disease 19 infection Coronavirus disease 19 infection YS-SC2-010 alone Yisheng Biopharma Co Ltd US, Europe, China, South East Asia Phase Not Applicable Planned 2 2020-06-11
A clinical study to evaluate the safety and tolerability of TY-027 for the treatment of COVID-19 Coronavirus disease 19 infection TY-027, Tychan alone Healthy volunteers accepted Tychan Pte Ltd Phase 1 Clinical Recruiting 0 23 2020-06-15
A clinical proof-of-concept study to assess SARS-CoV-2-specific virus-neutralizing antibodies for the potential treatment of COVID-19 Coronavirus disease 19 infection SARS-CoV-2-neutralizing monoclonal antibodies (COVID-19), Memo Therapeutics alone Memo Therapeutics AG 2020-12-31 Phase Not Applicable Planned 0 2020-06-11
An observation study to assess the effect of favipiravir in hospitalized patients with COVID-19 Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Fujita Health University Japan Phase Not Applicable Status not specified 1 2020-06-11
A clinical study of anti-SARS-CoV-2 spike glycoprrotein monoclonal antibody (COVID-19), Celletrion for the treatment of COVID-19 Coronavirus disease 19 infection S-protein modulator (COVID-19), Celletrion alone Moesin modulator Celltrion Healthcare Co Ltd 2020-07-31 Phase Not Applicable Planned 0 2020-06-15
PI-Covid-19: Primary Prevention of Infection by COVID-19 in Health Providers Coronavirus disease 19 infection immunostimulant therapy alone, Variable regimens including allicin , eugenol , quercetin Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Unidad de Investigación Genética Molecular Universidad de Antioquia Colombia 2020-07-31 2020-09-30 NCT04420260, PI-Covid-19, UNIGEM PT-IC-02 Phase 2 Clinical Not yet recruiting 1 2 Months 300 Beatriz H Aristizabal, PhD, Clara I Aristizabal, CEO, Clara Ines Aristizaba 2020-06-11
A trial to assess LVRNA-009 for COVID-19 vaccine Coronavirus disease 19 infection LVRNA-009 alone COVID19 Spike glycoprotein modulator Zhuhai Lifanda Biotechnology Co Ltd Phase Not Applicable Planned 0 2020-06-11
COVID-19-Related Health and Infection Control Practices Among Dentists Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) American Dental Association Foundation US 2020-06-08 2021-06-08 20-08, NCT04423770 Phase Not Applicable Recruiting 1 12 Months 4000 Cameron G Estrich, MPH, PhD, Marcelo Araujo, DDS, MS, PhD 2020-06-12
QuadraMune for Prevention of COVID-19 Coronavirus disease 19 infection QuadraMune alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Therapeutic Solutions International Inc US 2020-06-08 2020-11-08 NCT04421391, QUADRAMUNE002 Phase 2 Clinical Recruiting 1 5 Months 500 James Veltmeyer, MD, Thomas E Ichim, Thomas E Ichim, Ph.D 2020-06-11
BISCUIT: Bromhexine And Spironolactone For Coronаvirus Infection Requiring Hospitalization Coronavirus disease 19 infection, Viral pneumonia bromhexine plus spironolactone Aldosterone antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) MV Lomonosov Moscow State University Russian Federation 2020-05-16 2020-08-23 BISCUIT, MSU160520, NCT04424134 Phase 3 Clinical Recruiting 1 3 Months 80 Julia Begrambekova, Julia Begrambekova, Phd, Yana Orlova, Professor 2020-06-11
Needs of Persons With Spinal Cord Injury (SCI) Coronavirus disease 19 infection, Spinal cord injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US US 2020-05-22 2020-12-31 202005026, NCT04422769 Phase Not Applicable Recruiting 1 7 Months 250 Kerri A Morgan, PhD, Kimberly A Walker, OTD 2020-06-11
A clinical study to assess COVID-19 mRNA vaccine in the treatment of subjects with COVID-19 Coronavirus disease 19 infection mRNA vaccine (LPP delivery platform, COVID-19), Shanghai Yinuosi Biotechnology/Tongji University/Biocad/Stemrina Therapeutics alone Stemirna Therapeutics Co Ltd GenScript Biotech Corp China Phase Not Applicable Planned 1 2020-06-11
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity During the COVID19 Pandemic Coronavirus disease 19 infection, Infectious disease, Mitochondrial disease Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Human Genome Research Institute National Institutes of Health Clinical Center US 2020-06-17 2025-05-01 20-HG-N120, 999920120, NCT04419870 Phase Not Applicable Not yet recruiting 1 58 Months 200 Eliza M Gordon-Lipkin, M.D., Shannon Kruk, Shannon Kruk, R.N. 2020-06-12
SANCO: A Saudi Arabia based study into the impact of coronavirus infection on the nervous system Ataxia, Cerebrovascular disease, Coronavirus disease 19 infection, Muscle injury, Neuropathic pain, Seizure disorder, Taste disorder, Vision disorder RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) King Saud Medical City Saudi Arabia 2020-03-01 2021-02-28 ISRCTN15475176, KSMC, IRB, H1RI-24-MAY20-01, SANCO Phase Not Applicable Recruiting 1 12 Months 1000 Prof Karakitsos 2020-06-15
CAPRI: Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients Coronavirus disease 19 infection ABO compatible anti-SARS-CoV-2 convalescent fresh frozen plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California San Francisco Blood Systems Inc, San Francisco General Hospital US 2020-06-08 2021-04-30 20-30794, CAPRI, NCT04421404 Phase 2 Clinical Not yet recruiting 1 10 Months 30 Annie Leutkemeyer, MD, Kelvin Moore, BA, Priscilla Hsue, MD, Rebecca Park, MS 2020-06-12
The effects of restricting going out on patients with chronic respiratory disease Coronavirus disease 19 infection, Respiratory disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Asahi Rosai Hospital Japan 2020-06-12 UMIN000040715 Phase Not Applicable Recruiting 1 300 Tomohiro Kawaji 2020-06-15
LOWRAD-Cov19: Low Dose Radiotherapy for COVID-19 Pneumonitis Coronavirus disease 19 infection, Viral pneumonia radiotherapy alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinico San Carlos Spain 2020-05-01 2020-09-08 LOWRAD-COV19, LOWRAD-Cov19, NCT04420390 Phase Not Applicable Recruiting 1 4 Months 41 Manuel Gonzalo Vazquez Masedo, MD, PhD, Manuel Gonzalo Vazquez Masedo, MD,PhD, Manuel Gonzalo Vázquez Masedo, MD 2020-06-15
FRENCH ICU: Study of the Increase in ICU Beds Capacity During COVID-19 Pandemic in France Coronavirus disease 19 infection Centre Hospitalier Universitaire de Nimes France 2020-05-06 2020-06-05 30RC20_0117, FRENCH ICU, NCT04420286 Phase Not Applicable Recruiting 1 1 Month 9000 Jean-Yves LEFRANT, Jean-Yves LEFRANT, MD, PhD 2020-06-15
RetroCov: Impact of the Covid-19 Pandemic on Gastrointestinal and Liver Diseases Coronavirus disease 19 infection, Decompensated liver cirrhosis, Gastrointestinal disease, Liver disease antiviral drug therapy alone Medical University of Graz Austria 2020-06-15 2021-12-31 NCT04420637, RETROCOV, RetroCov Phase Not Applicable Not yet recruiting 1 18 Months 1000 Vanessa Stadlbauer, MD 2020-06-14
Study of ivermectin against COVID-19 Coronavirus disease 19 infection ivermectin alone, standard of care therapy alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Huvepharma Eood Bulgaria 2020-05-15 2020-002091-12, HUVE-19-CT-001 Phase 2 Clinical Recruiting 1 120 2020-06-13
A Phase III clinical trial of NLP-21 for the treatment of COVID-19 Coronavirus disease 19 infection NLP-21 alone NovaLead Pharma Pvt Ltd India Phase 3 Clinical Not yet recruiting 1 150 2020-06-11
GETAFIX: A study comparing favipiravir versus standard of care management as an early treatment arm in COVID-19 Hospitalized patients Coronavirus disease 19 infection favipiravir alone, supportive care alone RNA polymerase inhibitor Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) NHS Greater Glasgow and Clyde, University of Glasgow UK 2020-05-20 2020-001904-41, GETAFIX, GETAFIX-2020 Phase 2 Clinical Recruiting 1 Liz-Anne Lewsley 2020-06-13
Efficacy and Safety of Nitazoxanide 600 mg, tid for the Treatment of Hospitalized Patients With COVID-19 Coronavirus disease 19 infection, Respiratory failure nitazoxanide (Viranitta) alone, standard of care alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azidus Brasil Farmoquimica SA, Vera Cruz Casa de Saúde Campinas 2020-07-31 2020-08-31 NCT04423861, NITFQM0520OR Phase 2 Clinical Not yet recruiting 0 1 Month 50 Florentino de Araujo Cardoso Filho, MD, PhD, Luciana Ferrara 2020-06-15
Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19 Coronavirus disease 19 infection, Viral pneumonia standard treatment alone, chloroquine plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva Brazil 2020-04-16 2020-06-01 CLOROTRIAL, NCT04420247 Phase 3 Clinical Suspended 1 1 Month 54 ALVARO REA-NETO, MD 2020-06-15
Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada) Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) McGill University Health Center, Research Institute of the McGill University Health Centre Eastern Health, Lawson Health Research Institute, McMaster University, University of Alberta, University of British Columbia, University of Manitoba, University of Minnesota US, Canada 2020-03-25 2020-08-26 2020-6549, NCT04421664 Phase 3 Clinical Recruiting 8 5 Months 1500 Emily G McDonald, MD MSc, Glen Drobot, MD, Ilan Schwartz, MD, Lauren E Kelly, PhD, Lauren MacKenzie, MD, Matthew P Cheng, MD, Michael Silverman, MD, Peter Daley, MD MSc, Ryan Zarychanski, MD, Sara Belga, MD, Sylvain Lother, MD, Todd C Lee, MD MPH FIDSA, Zain Chagla, MD 2020-06-15
Hydroxychloroquine in comparison with hydroxychloroquine + azithromycin in patients with covid-19 Coronavirus disease 19 infection azithromycin plus hydroxychloroquine Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University Iran 2020-05-19 IR.SBMU.RETECH.REC.1399.069, IRCT20200428047228N2 Phase 3 Clinical Recruiting 1 40 Dr. Mohammad Fathi, ِDr.Mohammad Fathi 2020-06-15
Pentaglobin effect in critically ill patients with COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Anticoagulant therapy alone, oxygen therapy alone, pentaglobin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University of Medical Sciences, Laser Application in Medical Sciences Research Center Iran 2020-06-22 IR.SBMU.NRITLD.REC.1399.014, IRCT20151227025726N18 Phase 2/Phase 3 Clinical Not yet recruiting 1 30 Farzaneh Dastan, Payam Tabarsi 2020-06-12
COPROS study: COVID-19 in professional soccer players Coronavirus disease 19 infection Amphia Hospital Netherlands 2020-05-18 2020-09-01 COPROS study, NL8685, W20.108 Phase Not Applicable Recruiting 1 3 Months 140 Jan Kluytmans 2020-06-15
COVID-19 treatment outcomes at the University Medical Center Freiburg Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Albert-Ludwigs-Universität Freiburg Germany 2020-05-31 DRKS00021775 Phase Not Applicable Recruiting 1 400 Mr. Prof. Dr. Siegbert Rieg 2020-06-12
TMD: Targeted Melanoma Detection With Skin Self-Examination During COVID-19 Restricted Physician Access Coronavirus disease 19 infection, Melanoma Home sample collection of concerning mole with physician supervision alone, SSE educational intervention alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Northwestern University US 2020-06-15 2021-12-30 COVID_IMPACT, NCT04420273, STU00212165, TMD Phase Not Applicable Not yet recruiting 1 18 Months 1000 Dalya A Durst, June K Robinson, MD 2020-06-15
Maintenance Versus Reduction of Immunosuppression for Renal Transplant Patients Hospitalized With COVID-19 Disease Coronavirus disease 19 infection, Kidney transplantation Maintenance of immunosuppression alone, azathioprine alone, mycophenolate mofetil alone Inosine monophosphate dehydrogenase inhibitor, PurH purine biosynthesis protein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Brigham & Women's Hospital US 2020-07-01 2021-12-31 2020P001516, NCT04420364 Phase 2/Phase 3 Clinical Not yet recruiting 1 18 Months 50 Finnian R Mc Causland, MBBCh, MMSc, Jamil Azzi, MD, PhD 2020-06-15
Telematic Monitoring Through a Mobile Application of Patients With COVID-19 Coronavirus disease 19 infection Farmalarm alone, SMART PULSE OXIMETER OL-750 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Vall D'Hebron Spain 2020-03-31 2020-05-18 NCT04423289, PR(AG)182-2020 Phase Not Applicable Completed 1 1 Month 150 Oscar Len, MD, PhD 2020-06-12
External Dead Space in Ventilated Covid-19 Patients Coronavirus disease 19 infection apparatus dead space alone, mechanical ventilation alone, volumetric capnography alone Karolinska Institutet Stockholm County Council Sweden 2020-06-07 2020-09-07 KAROLINSKA, NCT04424082 Phase Not Applicable Recruiting 1 3 Months 40 Björn Persson, MD PhD, Jacob Karlsson, MD PhD, Per-Arne Lönnqvist, Prof 2020-06-15
BREATH: Baricitinib for corona Virus pneumonia (COVID-19): a Therapeutic Trial Coronavirus disease 19 infection, Pneumonia baricitinib alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) IRCCS Policlinico San Matteo Italy 2020-05-15 2020-11-15 2020-001185-11, BREATH, NCT04399798 Phase 2 Clinical Not yet recruiting 1 6 Months 13 Carlomaurizio Montecucco, Prof, Raffaele Bruno, Prof, Sara Monti, MD, Valentina Zuccaro, MD 2020-06-12
COVID-19 Virtual Care at Home Coronavirus disease 19 infection VIRTUES platform alone, Virtual Care at Home alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lawson Health Research Institute Cardiac Arrhythmia Network of Canada Canada 2020-06-08 2021-12-31 CTO 3210, NCT04420182 Phase Not Applicable Not yet recruiting 1 18 Months 2000 Anthony Tang, MD, Marko Mrkobrada, MD, Sabrina Wall 2020-06-12
Co-STAR: Coronavirus Smell Therapy for Anosmia Recovery Coronavirus disease 19 infection, Dysomia budesonide alone, high-concentration essential oil olfactory training alone, low-concentration essential oil olfactory training alone, nasal saline lavage alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US US 2021-06-01 2023-12-31 Co-STAR, NCT04422275, PA-18-334 Phase 2 Clinical Not yet recruiting 1 31 Months 200 Jay F. Piccirillo, MD 2020-06-13
A prospective, interventional, single-active-arm, single-center pilot trial of mavrilimumab for the treatment of patients with severe pneumonia and hyperinflammation associated with COVID-19 Coronavirus disease 19 infection, Inflammatory disease, Respiratory distress syndrome, Viral pneumonia mavrilimumab alone, standard of care therapy alone C-reactive protein inhibitor, Chemokine CC22 ligand inhibitor, GM-CSF receptor antagonist, Hemoglobin scavenger receptor antagonist, Metalloprotease-1 inhibitor, Metalloprotease-3 inhibitor, Small inducible cytokine A17 ligand inhibitor, VEGF gene inhibitor Kiniksa Pharmaceuticals Ltd Italy Phase Not Applicable Status not specified 1 13 Lorenzo Dagna 2020-06-15
A global, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of mavrilimumab in addition to standard of care therapy in the treatment of patients with severe COVID-19 pneumonia and hyperinflammation Coronavirus disease 19 infection, Lung inflammation, Viral pneumonia mavrilimumab alone, standard of care therapy alone C-reactive protein inhibitor, Chemokine CC22 ligand inhibitor, GM-CSF receptor antagonist, Hemoglobin scavenger receptor antagonist, Metalloprotease-1 inhibitor, Metalloprotease-3 inhibitor, Small inducible cytokine A17 ligand inhibitor, VEGF gene inhibitor Kiniksa Pharmaceuticals Ltd Phase 2/Phase 3 Clinical Planned 0 580 2020-06-14
A clinical trial to assess the safety and effectivness of Russian Coronavirus Vaccine in healthy volunteers Coronavirus disease 19 infection anti-coronavirus vaccine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Ministry of Defence of the Russian Federation Russian Federation Phase Not Applicable Recruiting 1 50 2020-06-11
PULCO-19: Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia Coronavirus disease 19 infection, Lung injury, Viral pneumonia pulmonary anomaly test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-05-28 2022-05-31 NCT04422613, PULCO-19, RC31/20/0181 Phase Not Applicable Recruiting 1 24 Months 60 Elise Noël-Savina, MD 2020-06-15
Clinical Trial on the Efficacy and Safety of Bemiparin in Patients Hospitalized Because of COVID-19 Coronavirus disease 19 infection bemiparin alone Factor Xa antagonist, Heparin agonist, Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HM Research Foundation Hospitals Syntax for Science Spain 2020-06-04 2021-03-31 2020-001548-24, BEMICOVID-19, NCT04420299 Phase 2 Clinical Recruiting 2 9 Months 120 Antonio Cubillo, MD, Elena Nuñez Cuerda, MD, José Felipe Varona, MD 2020-06-12
Impact of Burnout on Cardiovascular and Immune Biomarkers in Healthcare Professionals - Covid-19 Pandemic in Abu Dhabi Cardiovascular disease, Coronavirus disease 19 infection, Immune disorder, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Khalifa University Of Science & Technology & Research (Kustar) Abu Dhabi University, AE, Cleveland Clinic Abu Dhabi, Mediclinic Middle East, Sheikh Khalifa Medical City, Sheikh Shakhbout Medical City, Zayed Military Hospital United Arab Emirates 2020-06-14 2020-12-31 CPRA-2020-034, NCT04422418 Phase Not Applicable Recruiting 4 6 Months 200 Ahmad Mounir, MD, Hashel Al Tunaiji, MD MSc, Nadya Matroushi, MD, Ovidiu C Baltatu, MD PhD, Seema El Khider Nour, MD, Wael Almahmeed, MD 2020-06-15
C3PI: Murdock Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study Coronavirus disease 19 infection biological sampling alone, polymerase chain reaction alone, serological testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Duke University North Carolina Department of Health and Human Services US 2020-06-15 2021-06-30 C3PI, NCT04424004, PRO00105703 Phase Not Applicable Not yet recruiting 1 12 Months 500 Abha Singh, Carla Kingsburg, Kristin Newby, MD 2020-06-12
The Impact of COVID-19 on Dialysis Users Coronavirus disease 19 infection, End stage renal disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Portsmouth Portsmouth Hospitals, University of Reading UK 2020-06-03 2020-09-03 004, NCT04422873 Phase Not Applicable No longer recruiting 1 3 Months 40 Dr Zoe Saynor, Senior Lecturer 2020-06-11
Utility of Lactoferrin as an Adjunct Therapeutic Agent for COVID-19 Coronavirus disease 19 infection Standard of care alone, lactoferrin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Cairo University Egypt 2020-06-30 2020-11-30 CUKA-001, NCT04421534 Phase 2/Phase 3 Clinical Not yet recruiting 1 5 Months 150 Gamal Esmat 2020-06-11
ACES: Angiotensin II Infusion in COVID-19-Associated Vasodilatory Shock: A multinational, multicenter registry Cardiogenic shock, Coronavirus disease 19 infection Angiotensin II alone, novel therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Austin Health Australian and New Zealand Intensive Care Research Centre, Monash University UK, Belgium, Italy, Germany, Australia, Canada 2020-06-15 2020-12-30 ACES, ACTRN12620000620921 Phase Not Applicable Not yet recruiting 9 6 Months 315 Dr Ary Serpa Neto, Mr Tony Trapani, Prof Rinaldo Bellomo 2020-06-12
BEAT: Open label, prospective study for the Biofourmis Everion armband telemonitoring solution for patients during COVID-19 home isolation within South Western Sydney Coronavirus disease 19 infection Everion armband alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) South Western Sydney Local Health Network Ingham Institute for Applied Medical Research Australia 2020-06-05 2020-09-30 ACTRN12620000635965, BEAT Phase Not Applicable Not yet recruiting 6 3 Months 50 Prof Josephine Chow 2020-06-12
Analysis of the Inflammatory Response and the Development of Humoral and Cellular Immunity in Patients With COVID-19 Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Coordinacion de Investigacion en Salud Instituto Mexicano del Seguro Social Mexico 2020-04-15 2020-08-15 NCT04423640, R-2020, 3601-043 Phase Not Applicable Recruiting 1 4 Months 200 Constantino López Macías, PhD, Eduardo Ferat-Osorio, PhD, Suria Loza Jalil, MD 2020-06-12
A potential use of VAL-201 in a combination treatment for patients suffering a hyperimmune response to Coronavirus SARS-CoV2 infection Coronavirus disease 19 infection VAL-201 alone Src tyrosine kinase inhibitor Black Cat Bio Limited, Oncolytika Limited ValiRx plc Phase Not Applicable Planned 0 2020-06-10
Knowledge, practices, and risk and susceptibility perceptions on exposure to COVID-19: A qualitative triangulation study on pregnant women, their spouses, and non-pregnant reproductive-aged women with healthcare workers in Metro Manila Coronavirus disease 19 infection Philippine General Hospital Philippines 2020-05-26 2021-05-26 PHRR200604-002695 Phase Not Applicable Not yet recruiting 1 12 Months Erlidia F. Llamas-Clark, MD, MPH, PhD, Maria Stephanie Fay S. Cagayan, Maria Stephanie Fay S. Cagayan, MD 2020-06-11
SeniorCOVIDRea: Senior-COVID-Rea Multicentric Survey Coronavirus disease 19 infection blood sampling alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2020-04-01 2020-08-15 69HCL20-0386, NCT04422340, SeniorCOVIDRea Phase Not Applicable Recruiting 5 4 Months 185 Claire Falandry, MD, Max Haine, MD, Vincent COLLANGE, MD 2020-06-11
EPRICOD: Evaluation of the COVID-19 Infection Response in Patients Admitted to the Emergency Department for Dyspnea Coronavirus disease 19 infection, Dyspnea Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-03-13 2021-06-30 EPRICOD, NCT04422587, RC31/20/0149 Phase Not Applicable No longer recruiting 1 15 Months 1860 Paul-Henri Auboiroux, MD 2020-06-10
PANDEMIC: Mental Health and Academic Performance in COVID-19 Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Mexicano del Seguro Social Mexico 2020-04-01 2020-07-30 MENTAL01, NCT04420416, PANDEMIC Phase Not Applicable Recruiting 1 3 Months 720 Alejandro Gonzalez Ojeda, PhD, Gonzalez Ojeda Alejandro 2020-06-10
ALTRISCOVID-19: Analysis of Long-Term Risk of Coronavirus Disease-19 Emergency Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto Neurologico Mediterraneo NEUROMED Italy 2020-06-08 2021-12-31 ALTRISCOVID-19, DEP 1/2020, NCT04422262 Phase Not Applicable Not yet recruiting 1 18 Months 10000 Licia Iacoviello, Licia Iacoviello, MD, PhD, Marialaura Bonaccio 2020-06-11
Tocilizumab in COVID-19 Positive Patients Coronavirus disease 19 infection, Inflammatory disease standard of care alone, tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Calgary Roche Holding AG Canada 2020-06-30 2021-06-30 NCT04423042, REB20-0713 Phase 3 Clinical Not yet recruiting 1 12 Months 30 Jacinda R Larson, PhD, Namneet Sandhu, MPH, Susanne Benseler, MD PhD 2020-06-11
SeroCOVIDial: Assessment of COVID-19 Seroconversion in Patients on Chronic Hemodialysis Patients and in Their Caregivers, a Cohort Study Coronavirus disease 19 infection Biosynex serological test alone, seroconversion assay alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille France 2020-06-05 2020-12-15 2020-34, 2020-A01515-34, NCT04420338, SeroCOVIDial Phase Not Applicable Recruiting 1 6 Months 800 Jean-Olivier ARBAUD, Director, Noémie JOURDE-CHICHE, PU-PH, Philippe BRUNET, PU-PH 2020-06-12
CYTOAID: Data Analysis of the Cytokine Adsorption Treatment on Coronavirus Disease-19 (COVID-19) Patients With Respiratory Failure Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure CytoSorb alone, cytokine adsorption therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Of Pécs 2020-07-01 2022-12-01 20802-5/2020/EUIG, CYTOAID, NCT04422626 Phase Not Applicable Not yet recruiting 0 29 Months 42 Péter Hegyi, MD, PhD, DSc, Péter Hegyi, MD, PhD, Dsc, Zsolt Molnár, MD, PhD, Dsc 2020-06-13
SEROPHUGAC: Serological Study of the Exposure of Personnel to Sars-cov-2 Coronavirus disease 19 infection RT-PCR alone, serology test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Centre Hospitalier Saint Joseph Saint Luc de Lyon 2020-06-08 2020-06-30 NCT04422977, SEROPHUGAC, SEROPHUGAC Phase Not Applicable Not yet recruiting 0 900 2020-06-11
SARS-CoV-2 PoC/ELISA: Evaluation of three commercially available rapid assays for detection of IgG and/or IGM antibodies to SARS-CoV-2 (COVID-19) for assessment of contact persons’ immune status and termination of quarantine and self-isolation – a prospective pilot study Coronavirus disease 19 infection COVID-19 antibody point-of-care test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Landesklinikum Neunkirchen Austria 2020-05-20 DRKS00022083, GS1-EK-3/168-2020, SARS-CoV-2 PoC/ELISA Phase Not Applicable Recruiting 1 70 Klaus Hackner 2020-06-11
SynCov: Synbiotic Therapy of Gastrointestinal Symptoms During COVID-19 Infection Coronavirus disease 19 infection, Diarrhea, Enteritis, Gastrointestinal disease Omnibiotic AAD alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical University of Graz Austria 2020-08-31 2022-12-31 NCT04420676, SYNCOV, SynCov Phase Not Applicable Not yet recruiting 1 28 Months 108 2020-06-11
COVID-EP: Cohort Comparing the Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms Coronavirus disease 19 infection, Lung embolism, Respiratory disease, Respiratory distress syndrome, Viral pneumonia CT pulmonary angiogram alone, computed tomography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Groupe Hospitalier Paris Saint-Joseph France 2020-03-01 2020-04-20 COVID-EP, COVID-EP, MR 4516150520, NCT04420312 Phase Not Applicable Completed 1 1 Month 1024 2020-06-11
Prophylactic Ivermectin in COVID-19 Contacts Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Zagazig University Egypt 2020-05-31 2020-07-31 NCT04422561, ZU-IRB-6150L31-5-2020 Phase 2/Phase 3 Clinical Recruiting 1 2 Months 100 Waheed Shouman, Waheed Shouman, MD 2020-06-11
PICS-COVID19: Post Intensive Care Syndrome in COVID-19 Patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Corporacion Parc Tauli Spain 2020-06-01 2022-06-01 2020/577, NCT04422444, PICS-COVID19 Phase Not Applicable Recruiting 1 24 Months 100 SOL FERNANDEZ, PhD, Sol Fernandez-Gonzalo, Sol Fernandez-Gonzalo, PhD 2020-06-13
IDENTIFY: Identification of a Responsive Subpopulation to Hydroxychloroquine in COVID-19 Patients Using Machine Learning Coronavirus disease 19 infection COViage alone Dascena US 2020-03-10 2020-06-04 060820, IDENTIFY, NCT04423991 Phase 2 Clinical Completed 1 2 Months 290 2020-06-12
Sero-prevalence of Coronavirus Disease 2019 (COVID-19) in Healthcare Workers Coronavirus disease 19 infection Ortho clinical diagnostics chemiluminescent technique alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Cairo University, Egyptian Center for Research and Regenerative Medicine Academy of Scientific Research and Technology, National Research Center Patent Office Egypt 2020-06-16 2020-09-30 COVID-19\004, NCT04424017 Phase Not Applicable Not yet recruiting 1 3 Months 726 Khaled Eissa Amer, MD 2020-06-12
Knowledge About Covid-19 Infection Coronavirus disease 19 infection counseling alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs) Aljazeera Hospital Egypt 2020-04-01 2020-06-20 KNOWLEDGE ABOUT COVID 19, NCT04423692 Phase Not Applicable Recruiting 1 2 Months 300 Mahmoud Alalfy, Mahmoud Alalfy, PhD 2020-06-10
QT-COVID-19: Effects on the Qt Interval of COVID-19 Coronavirus Infection Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital General Universitario Gregorio Marañon Spain 2020-05-29 2020-12-01 NCT04422535, QT-COVID-19, QT-COVID-19 Phase Not Applicable Recruiting 1 6 Months 80 Javier Hortal, MD PhD, Matilde Zaballos, Matilde Zaballos, MD, PhD, Matilde Zaballos, MDPhD 2020-06-12
CHRONOS19: Observational, Prospective, Cohort Study: Registry of Patients With Hematological Disease and COVID-19 in Russia Coronavirus disease 19 infection, Hematological disease, Hematological neoplasm Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hematology Research Center Russian Federation 2020-06-08 2021-07-08 CHRONOS19, CHRONOS19, NCT04422470 Phase Not Applicable Not yet recruiting 1 13 Months 200 Olga Gavrilina, PhD 2020-06-15
ICOLS: Implications of Covid-19 on the Lifestyle Changes Coronavirus disease 19 infection online survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Unita Sanitaria Locale di Reggio Emilia Italy 2020-05-04 2020-06-15 ICOLS, ICOLS_COVIDSTYLE, NCT04423978 Phase Not Applicable Recruiting 1 1 Month 1500 Elisa Mazzini, MD 2020-06-15
A phase II clinical trial to evaluate the efficacy of JS-016 in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection JS-016 alone COVID19 Spike glycoprotein inhibitor Eli Lilly & Co, Shanghai Junshi Biosciences Co Ltd Phase 2 Clinical Planned 0 2020-06-10
COVID-19 and Liver Injury in Patients With or Without Underlying Liver Disease: A Multicenter, Retrospective-prospective, Observational Study Coronavirus disease 19 infection, Liver disease, Liver failure, Liver injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Max Healthcare Institute Ltd, India India 2020-06-07 2020-08-30 COVID 19/LI/2020, NCT04422379 Phase Not Applicable Not yet recruiting 1 2 Months 314 Kaushal Madan, DM, Rajesh Saxena, Vivek Raj, DM 2020-06-12
PneumoSeroCov: COVID-19 Serology in Pulmonologists Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-05-01 2020-05-30 NCT04422574, PneumoSeroCov, RECHMPL20_0343 Phase Not Applicable Completed 1 97 Arnaud Bourdin, MD PhD 2020-06-15
The Safety and Efficacy of Imatinib for the Treatment of SARS-COV-2 Induced Pneumonia Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Respiratory failure, Viral pneumonia imatinib alone, standard treatment alone Abl tyrosine kinase inhibitor, Bcr protein inhibitor, Kit tyrosine kinase inhibitor, PDGF receptor antagonist, Signal transduction inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Alexandria Science, Technology and Innovation Funding Authority (STIFA) Egypt 2020-06-30 2020-10-31 ALEX CCM 2020/5, NCT04422678 Phase 3 Clinical Not yet recruiting 1 4 Months 30 ASSAAD, MD, PhD, Hany ASSAAD, MD, PhD 2020-06-12
Endoscopic Interventions in Patients With COVID-19 Coronavirus disease 19 infection endoscopic intervention alone University Hospital Tubingen Germany 2020-03-01 2020-05-15 242/2020BO2, NCT04423003 Phase Not Applicable Completed 1 2 Months 10 2020-06-11
Thrombosis Risk Assessment and Clinical Presentation of Covid-19 Pneumonia Coronavirus disease 19 infection, Thrombosis, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nisantasi University Turkey 2020-06-30 2020-07-31 20200504443, NCT04423315 Phase Not Applicable Not yet recruiting 1 1 Month 70 Hasan Haciosman, M.D., Murat Civan, M.D. 2020-06-12
Investigational COVID-19 Convalescent Plasma Infusion for Severely or Life-threateningly Ill COVID-19 Patients Coronavirus disease 19 infection, Multiple organ failure, Respiratory failure, Septic shock COVID-19 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rutgers University University Hospital, Newark, New Jersey US NCT04420988, PRO2020000746, PRO2020000911 Phase Not Applicable Recruiting 2 Khyati Mehta, MPH, Marc Klapholz, MD, MBA 2020-06-15
COVIDUS-NOR: Ultrasonography in Norwegian Emergency Department Patients With Suspected Covid-19 Infection Coronavirus disease 19 infection Ultrasonography alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Olavs Hospital Drammen Hospital, Haukeland University Hospital, Helse Stavanger HF, Nordlandssykehuset HF, Sorlandet Hospital, Sykehuset Telemark, Ullevaal University Hospital, University Hospital, Akershus Norway 2020-07-01 2025-12-31 COVIDUS-NOR, NCT04422691, REK129805 Phase Not Applicable Not yet recruiting 9 66 Months 200 Anders B Martinsen, MD, Benedicte Severinsen, MD, Eirik H Ofstad, MD, PhD, Harry Achterberg, MD, Jay Shyamal Chotai, MD, Jørn Rasmussen, MD, Lars E Næss-Pleym, Lars Petter Bjørnsen, MD, PhD, Rune Bjørneklett, MD, PhD, Øistein Rønneberg Mjelva, MD, PhD 2020-06-12
Fibromyalgia During the Covid-19 Pandemic Coronavirus disease 19 infection, Fibromyalgia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Al-Azhar University Egypt 2020-03-15 2020-06-30 AAGH-01, NCT04422522 Phase Not Applicable No longer recruiting 1 3 Months 45 Ahmed Abogamal 2020-06-12
PTT-Online: Video Dance Class and Unsupervised Physical Activity During Covid-19 Pandemic in People With Parkinson's Disease Coronavirus disease 19 infection, Parkinsons disease video dance classes alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Federal University of Rio Grande do Sul Brazil 2020-05-01 2024-12-30 NCT04422353, PTT-Online, PTT-PARKINSON/COVID19 Phase Not Applicable Recruiting 1 55 Months 60 Aline N. Haas, PhD, Elren P. Monteiro, PhD, Flávia G. Martinez, PhD, Leonardo A Peyré-Tartaruga, PhD, Leonardo A. Peyré-Tartaruga, Leonardo A. Peyré-Tartaruga, PhD 2020-06-12
COV-BARRIER: A Study of Baricitinib (LY-3009104) in Participants With COVID-19 Coronavirus disease 19 infection, Viral pneumonia Background therapy alone, baricitinib alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eli Lilly & Co Spain, Mexico, Germany, US 2020-05-29 2020-09-01 17830, 2020-001517-21, COV-BARRIER, I4V-MC-KHAA, NCT04421027 Phase 3 Clinical Not yet recruiting 15 3 Months 400 Adrian Camacho Ortiz, Andrew Catanzaro, Dora Patricia Cornejo Juárez, Gustavo Rojas Velasco, Luis Enrique Soto Ramírez, Mark MacElwee, Michel Fernando Martínez Reséndez, Miriam Akasbi, Patrick Milligan, Phyllis Tien, Roberto Caricchio, Thomas Grunewald, Thomas Lawrie, Vicente Estrada, Vinay Malhotra 2020-06-11
HEART-COVID: Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children Coronavirus disease 19 infection, Myocarditis Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Assistance Publique Hopitaux de Paris France 2020-06-30 2020-12-31 APHP200632, HEART-COVID, NCT04420468 Phase Not Applicable Not yet recruiting 4 6 Months 20 Clémence Marais, MD, Hélène Morel, Julie Starck, MD, Marion Grimaud, Marion Grimaud, MD, Michäel Levy, MD, Sylvain Renolleau, MD, PhD 2020-06-11
PAPESCO-19: Patients and Health Staff of Cancer Centres During the Covid-19 Pandemic Coronavirus disease 19 infection ELISA alone, RT-PCR alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut De Cancerologie De L'Ouest France 2020-06-15 2022-06-15 ICO-2020-16, NCT04421625, PAPESCO-19 Phase Not Applicable Not yet recruiting 1 24 Months 12000 Magali Briere, Magali Brière, Michele Boisdron-Celle, Michelle Boisdron-Celle 2020-06-11
Magnetic Resonance Imaging to Detect Signs of Viral Pneumonia in Patients With Coronavirus Infection: Multicenter, Prospective Study Coronavirus disease 19 infection, Lung injury, Viral pneumonia chest magnetic resonance imaging alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Research and Practical Center of Medical Radiology, Department of Health Care of Moscow Russian Federation 2020-05-19 2021-06-20 2020-2, NCT04424355 Phase Not Applicable Recruiting 1 13 Months 115 Olga Panina, Yuri Vasilev 2020-06-15
FCFM: Forecasting COVID-19 for Malaysia Coronavirus disease 19 infection Government of Malaysia Malaysia 2020-06-05 2022-05-31 FCFM, NMRR-20-1109-54838 Phase Not Applicable Not yet recruiting 1 23 Months Devi Peramalah, Prof. Dr Jamalludin Ab Rahman 2020-06-11
A phase II trial to assess Metablok in the prevention of acute organ inflammation and injury experienced by patients with COVID-19 Acute lung injury, Coronavirus disease 19 infection, Inflammatory disease, Renal injury, Respiratory distress syndrome Metablok alone Dehydropeptidase-1 modulator Arch Biopartners Inc US Phase 2 Clinical Planned 1 2020-06-10
DRDMMICPINSL Coronavirus disease 19 infection Robust Disease Modelling alone Government of Malaysia Malaysia 2020-06-04 2022-05-31 54839, NMRR-20-1102-54839 Phase Not Applicable Not yet recruiting 1 23 Months Devi Peramalah, he agent-based model 2020-06-11
PICOVID Coronavirus disease 19 infection povidone iodine alone Hospital Sungai Buloh Malaysia 2020-06-05 2020-07-01 54946, NMRR-20-1099-54946 Phase 2 Clinical Status not specified 1 60 Dr Shiraz Qamil bin Muhammad Abdul Kadar, dr IFFAH BINTI SALIM 2020-06-11
A randomized, double-blind, placebo-controlled, phase II study to assess the longer-term efficacy and safety pamrevlumab in patients who recovered or are recovering from COVID-19 infection with evidence of interstitial lung disease Coronavirus disease 19 infection, Interstitial lung disease pamrevlumab alone Connective tissue growth factor ligand inhibitor FibroGen Inc US Phase 2 Clinical Planned 1 2020-06-10
A randomized, double-blind, placebo-controlled, phase II study to assess efficacy and safety of pamrevlumab versus standard of care in hospitalized patients with acute COVID-19 infection Coronavirus disease 19 infection pamrevlumab alone Connective tissue growth factor ligand inhibitor FibroGen Inc US Phase 2 Clinical Planned 1 130 2020-06-10
BOREA: An open-label, phase II/III, randomized, parallel-arm , investigator-initiated study to evaluate the efficacy and safety of pamrevlumab versus standard of care in patients with severe coronavirus 2019 (COVID-19) infection Coronavirus disease 19 infection pamrevlumab alone Connective tissue growth factor ligand inhibitor FibroGen Inc Italy 2020-06-08 BOREA Phase 2/Phase 3 Clinical Recruiting 1 68 Professor Luca Richeldi 2020-06-10
A clinical trial of AZD-1222 in the volunteers who have not previously contracted COVID-19 Coronavirus disease 19 infection AZD-1222 alone COVID19 Spike glycoprotein modulator Federal University of Sao Paulo The Lemann Foundation Brazil Phase Not Applicable Not yet recruiting 1 2000 2020-06-10
DiSurE-Covid19: Evaluation of COVID-19 Surveillance Programme in University Malaya Medical Center Coronavirus disease 19 infection University Malaya Medical Centre Malaysia 2020-06-15 2022-08-31 55160, DiSurE-Covid19, NMRR-20-1097-55160 Phase Not Applicable Status not specified 2 26 Months Diane Chong Woei Quan 2020-06-11
Acceptance and Perception of the COVID-19 vaccination in the general population of Malaysia Coronavirus disease 19 infection COVID-19 vaccination alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institutes of Health Malaysia Malaysia 2020-06-02 2020-11-30 55153, NMRR-20-1089-55153 Phase Not Applicable Not yet recruiting 1 5 Months Dr June Lau Fei Wen 2020-06-11
A clinical study of camostat mesylate for the treatment of patients with COVID-19 infection Coronavirus disease 19 infection camostat mesylate alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Ono Pharmaceutical Co Ltd Phase Not Applicable Planned 0 2020-06-10
A clinical study on the safety of camostat mesilate in healthy volunteers Coronavirus disease 19 infection camostat mesylate alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Healthy volunteers accepted Ono Pharmaceutical Co Ltd 2020-06-05 Phase Not Applicable Recruiting 0 2020-06-10
SUCCESS: Surveillance of SARS-CoV-2 Virus Antibody in Health Care and Close-Contact Workers Coronavirus disease 19 infection COVID-19 antibody laboratory test alone, COVID-19 antibody point-of-care test kit alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kinki Health Administration Center (KKC), Mie Health Checkup Clinic Japan 2020-06-10 2021-07-31 SUCCESS, UMIN000040694 Phase Not Applicable Not yet recruiting 1 13 Months 1000 Masakatsu Nishikawa 2020-06-10
YOCO: Yoga Pranayama Adjuvant to Treat Burden COVID-19 Coronavirus disease 19 infection Morning pranayama alone, Pre dinner pranayama alone, Pre lunch pranayama alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Health Ricerca e Sviluppo Srl Casa di Riposo e Ambulatorio Giardino St Lucia, Massa Lomabarda (Ra) Italy, EJTN GEIE, Halnet Srl, Swami Vivekananda Yoga Anusandhana Samsthana Svyasa, Yoga Experience Association Italy 2020-06-01 2021-09-30 2020-001731-28, 2020_COVID19_YOGA, NCT04413747, YOCO Phase Not Applicable Not yet recruiting 1 16 Months 1000 Boris Bazzani, ERYT, Enrico Ricci, MD, Giorgio Noera, MD, PhD, HR Nagendra., Eng, Luca Ghetti, Eng., Maria Donatella Barbagallo, MD, Maria Luisa Vitobello, Morena Gaddoni, Morena Gaddoni, MD, Nagarathna Raghuram, MD 2020-06-10
DEXDO-COVID: Immunomodulatory Profile of Dexmedetomidine Sedation in Patients Recovering After ARDS Covid-19 Adult respiratory distress syndrome, Coronavirus disease 19 infection, Immune disorder dexmedetomidine alone Alpha 2 adrenoceptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-04-24 2021-02-28 2020-A00799-30, APHP200413, DEXDO-COVID, NCT04413864 Phase 2 Clinical Recruiting 1 10 Months 50 Alexandre Demoule, MD, PhD, Alexandre Demoule, Md, PhD, Alice JACQUENS, Vincent DEGOS, Pr 2020-06-10
Photodynamic Therapy for the Treatment of COVID-19 Coronavirus disease 19 infection Laser acupuncture alone, Methylene blue alone, photobiomodulation alone, photodynamic therapy alone Cairo University 2020-08-31 2021-02-28 CU-NILES/16/20, NCT04416113 Phase Not Applicable Not yet recruiting 0 6 Months 60 Cairo University 2020-06-12
Assessment of N-95 Facemask for Use in COVID-19 Pandemic in Case of Shortage of Personal Protective Equipment Coronavirus disease 19 infection Assembled mask alone, Hans Rudolph mask naso-oral mask alone, Iso-Gard HEPA light Filter 28022 alone, RP Performax SE ELBOW alone, Respironics Performax Whole Face Mask alone, Teleflex Bacterial/Viral filter 1605 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oklahoma US Department of Veterans Affairs US 2020-06-15 2025-05-31 11887, NCT04416919 Phase Not Applicable Not yet recruiting 1 59 Months 20 Ahel El Haj Chehade, MD, Houssein Youness, MD 2020-06-11
Evaluation of the effects of Oxycodone administration on pain control in patients with COVID-19 Coronavirus disease 19 infection, Dyspnea, Pain oxycodone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-03-20 IR.SBMU.NRITLD.REC.1399.012, IRCT20150107020592N24 Phase 3 Clinical Recruiting 1 60 Dr Mahmood Heydari, Dr Seyed Mohamadreza Hashemian, Seyed Mohammad Reza Hashemian 2020-06-10
A Clinical Study to Assess the Natural History of COVID-19 and Effects of KB109 and Supportive Self-care in Outpatients With Mild-to-moderate COVID-19 Coronavirus disease 19 infection KB-109 alone, Self Supportive Care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kaleido Biosciences Inc US 2020-06-30 2020-12-31 K031-120, NCT04414124 Phase 2 Clinical Recruiting 8 6 Months 400 Mark Wingertzahn, PhD 2020-06-11
Clinical Trial On Mildly Symptomatic Covid -19 Patients And Health Care Workers Posted To Covid Wards Coronavirus disease 19 infection A Mulmina Mango alone, Mulmina Amla Orange alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Jagdale industries pvt Ltd India 2020-06-15 CTRI/2020/06/025702, Protocol Version 1.0 Phase 3 Clinical Not yet recruiting 1 80 Dr Ashok Godavarthi, Dr C R Jayanthi, Mr Raghavendra K V 2020-06-11
iCOVID19 Project: This study has been conducted to collect the Cough and breathing sound of COVID-19 positive and COVID-19 negative patients for analysis of early indication of COVID-19 in humans Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Imperial Clinical Research Services India 2020-06-15 CTRI/2020/06/025675, iCOVID19 Project Phase Not Applicable Not yet recruiting 1 600 Ajeet Nanda, Amlendu Yadav, Pragya Yadav 2020-06-11
O-CovAb: Oral Fluid Sars-CoV-2 Ab Rapid test Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Diabetes Research Society India 2020-06-16 CTRI/2020/06/025674, O-CovAb Phase Not Applicable Not yet recruiting 3 100 Prof N Partha Sarathy, Prof PV Rao, Prof V Chandrasekhar 2020-06-11
An off-label, prospective, observational study to assess the effect of acalabrutinib in patients with acute respiratory distress syndrome (ARDS) from COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome acalabrutinib alone Btk tyrosine kinase inhibitor AstraZeneca plc, US Oncology Inc National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Walter Reed Army Medical Center US Phase Not Applicable Status not specified 3 19 2020-06-10
Validating an ELISpot for Early Detection of an Active Immune Response Against COVID-19 Coronavirus disease 19 infection ELISpot alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Nice France 2020-06-01 2021-06-01 20-PP-10, NCT04418206 Phase Not Applicable Not yet recruiting 4 12 Months 300 DUMON MARIE CHRISTINE, LEROUSSEAU LIONEL, LEROY SYLVIE, LEROY Sylvie, Leroy Sylvie, Rolland Fabien, griffonnet Jennifer, lerousseau lionel, rolland Fabien 2020-06-11
Investigation of the effects of prone position on cardiac and respiratory status in patients with coronavirus Coronavirus disease 19 infection, Respiratory disease prone position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Lorestan University Iran 2020-06-21 IR.LUMS.REC.1399.059, IRCT20160126026217N4 Phase Not Applicable Not yet recruiting 1 74 Ebrahim Falahi, Sajad Yarahmadi 2020-06-11
Prospective, cohort study of COVID-19 antibody for medical stuff in hospital Coronavirus disease 19 infection Gunma Prefectural Cancer Center Japan 2020-06-08 UMIN000040679 Phase Not Applicable Not yet recruiting 1 50 Kazuhiro Araki 2020-06-10
Longitudinal study on work style change, health and well-being due to pandemic of novel coronavirus infection (COVID-19) Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Keio University Atrae Inc, Nittsu System Co Ltd Japan 2020-06-08 20E0004, UMIN000040683 Phase Not Applicable Not yet recruiting 1 2000 Akihito Shimazu, Satoko Fujihara 2020-06-10
A global study of eritoran in hospitalized patients who tested positive with SARS-CoV-2 infection (COVID-19) Coronavirus disease 19 infection eritoran alone TLR-4 antagonist Eisai Co Ltd 2020-06-30 Phase Not Applicable Planned 0 400 2020-06-09
A Phase II clinical trial of AQCH for potential treatment of COVID-19 Coronavirus disease 19 infection AQCH alone Sun Pharmaceutical Industries Ltd India Phase 2 Clinical Not yet recruiting 1 210 2020-06-09
Ulinastatin for COVID-19 in patients with breathlessness Coronavirus disease 19 infection, Respiratory distress syndrome Variable regimens including azithromycin , hydroxychloroquine , ulinastatin (sepsis/acute pancreatitis), Bharat Serums and Vaccines Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Bharat Serums & Vaccines Ltd India 2020-07-01 BSV_ULINA_20_03_IN, CTRI/2020/06/025704 Phase 3 Clinical Not yet recruiting 6 120 Dr Amlendu Yaadav, Dr Apurva Agarwal, Dr Dibakar Sahu, Dr Harish Mallapura Maheshwarappa, Dr Madhusudan Jaju, Dr Rohidas Borse, Dr Shreepad Bhat, Dr Uday Harle 2020-06-11
Phase II study to evaluate the safety and efficacy of 2-Deoxy-D-Glucose in COVID-19 patients Coronavirus disease 19 infection 2-deoxy-D-glucose alone, standard-of-care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Dr Reddy's Laboratories Ltd, Institute of Nuclear Medicine and Allied Sciences (INMAS) India 2020-06-15 CTRI/2020/06/025664, CVD-19-CD-002, Version 2.0 Phase 2 Clinical Not yet recruiting 1 40 D Mallikarjuna Rao, Dr Apurva Agarwal 2020-06-10
To Assess the Safety and Outcome of Herbal Medicine in Prevention of COVID-19 Infection Among High Risk Population Coronavirus disease 19 infection Variable regimens including behidana , khameera marwareed , oshanda , sapistan , unnab Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ministry of Ayush India 2020-06-15 CTRI/2020/06/025650 Phase 2 Clinical Not yet recruiting 1 4000 Prof Abdul Wadud 2020-06-10
In vivo use of ivermectin (IVR) for treatment for corona virus infected patients: a randomized controlled trial Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Rayak Hospital Iraq, Lebanon 2020-06-10 2020-07-31 ChiCTR2000033627 Phase 0 Clinical Not yet recruiting 2 1 Month 60 Dr. Houssam RaaD, Mirna Fawaz 2020-06-10
A study on association between tobacco and COVID 19 to help policy makers Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Scottish Funding Council, University of Edinburgh India 2020-06-15 COVID_IMPACT, CTRI/2020/06/025673 Phase Not Applicable Not yet recruiting 1 50 Muralidhar Kulkarni 2020-06-10
A medical records based study for nano short peptide nutrition intervention on the prognosis of patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Nano short peptide enteral nutrition alone, whole protein enteral nutrition alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The First College Of Clinical Medical Science, China Three Gorges University China 2020-05-07 2020-06-17 ChiCTR2000033609 Phase Not Applicable Not yet recruiting 1 1 Month 206 Ze-Lin Zhang 2020-06-10
Prophylactic study of outbreak of novel coronavirus in Indian scenario in Distric Hospital, Vidisha Coronavirus disease 19 infection piper betal plus swarnabhasma Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Government medical college, Bhopal India 2020-06-22 CTRI/2020/06/025637 Phase Not Applicable Not yet recruiting 1 10 Dr Sarvesh Sharma 2020-06-10
Analysis of Characteristics of recurrent positive RT-PCR findings of recovered patients from novel coronavirus pneumonia (COVID-19) in Wuhan, China: a medical records based study Coronavirus disease 19 infection, Viral pneumonia Yunnan Center for Disease Control and Prevention China 2020-01-01 2020-03-20 ChiCTR2000033580 Phase Not Applicable Completed 1 2 Months 758 SHUI TIEJUN 2020-06-10
To evaluate the effect of herbal medicine in prevention and management of COVID-19 Coronavirus disease 19 infection Joshanda (Decoction) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ministry of Ayush, National Institute of Unani Medicine India 2020-06-15 CTRI/2020/06/025672 Phase 2/Phase 3 Clinical Not yet recruiting 1 60 Dr Fasihur Rehman Ansari, Dr Mariyam Ahad, Dr Mohd Aleemuddin Quamri 2020-06-10
A clinical trial to evaluate the medicinal efficacy of Ayurvedic Tablet Bhoumya and Tablet Saathmya in COVID-19 positive Patients Coronavirus disease 19 infection, Viral pneumonia standard care alone, Bhoumya plus Saathmya Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Prashanthi Ayurvedic Centre India 2020-06-15 CTRI/2020/06/025671 Phase 3 Clinical Not yet recruiting 1 10 Dr C R Jayanthi, Dr Giridhara Kaje, Dr Harish M 2020-06-10
PREVENGHO-COVID: PrevengHo-Vir Homeoprophylaxis COVID-2019 Coronavirus disease 19 infection PrevengHo-Vir alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Instituto Pedro Kouri Cuba 2020-04-29 2020-12-31 PREVENGHO-COVID, RPCEC00000312 Phase 1 Clinical Recruiting 1 8 Months 180 Carlos Eugenio Royo Lafita, Elsida Lucía Rey Robira, Johann Perdomo Delgado 2020-06-10
CIGB-258 at COVID-19 Coronavirus disease 19 infection CIGB-258 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Genetic Engineering and Biotechnology Instituto Pedro Kouri Cuba 2020-03-31 2020-04-30 CIGB-258/2020, RPCEC00000313 Phase 2 Clinical No longer recruiting 1 1 Month 16 Daniel González, Maria Carmen Domínguez Horta, Rafael Venegas Rodriguez 2020-06-15
Convalescent Antibodies Infusion in COVID-19 Patients Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia anti-coronavirus antibody therapy alone, double-filtration plasmapheresis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ospedale Papa Giovanni XXIII Aferetica Srl Italy 2020-06-30 2020-09-30 DFPP COVID 19 EARLY, NCT04418531 Phase 2 Clinical Not yet recruiting 6 3 Months 10 Anna Falanga, MD, Annapaola Callegaro, MD, Claudio Farina, MD, Diego Curtò, MD, Federica Casiraghi, Ferdinando Luca Lorini, MD, Giuseppe Remuzzi, MD, Laura Castellani, Biol.Sci.D, Lorenzo Grazioli, MD, Luca Barcella, MD, Marina Marchetti, Biol.Sci.D, Marina Noris, Ch., Piero Luigi Ruggenenti, Piero Luigi Ruggenenti, MD, Roberto Cosentini, MD, Stefano Rota, MD 2020-06-10
Peri-Operative NLR in Emergency General Surgery During COVID-19 Pandemic Coronavirus disease 19 infection emergency general surgery alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Barking Havering & Redbridge University Hospitals Nhs Trust UK 2020-03-23 2020-06-30 133196, NCT04419571 Phase Not Applicable No longer recruiting 1 3 Months 100 Nader Habib Bedwani 2020-06-10
Online Learning of Veterinary Anatomy During COVID-19 Pandemic Coronavirus disease 19 infection online survey alone, online veterinary anatomy learning alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs) South Valley University Egypt 2020-06-05 2020-07-05 2-2020, NCT04418284 Phase Not Applicable Not yet recruiting 1 1 Month 400 Mohamed Mahdy, Mohamed Mahdy, PhD 2020-06-08
Vocal Feature Analysis Algorithm Coronavirus disease 19 infection Vocal Feature Analysis (VFA) algorithm app (Soniphi) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Soniphi LLC UserWise US 2020-06-30 2020-12-31 002 SONIPHI, NCT04418544 Phase Not Applicable Recruiting 1 6 Months 400 Lauren Vitalie, BA, Matthew Sanderson, BS 2020-06-08
COVID-HOP: Establishment of a Biological Collection During COVID-19 Serological Screening in APHP Professionals Coronavirus disease 19 infection biological sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris Fondation Hôpitaux de Paris-Hôpitaux de France France 2020-06-30 2022-03-31 2020-A01364-35, APHP200609, COVID-HOP, NCT04418375 Phase Not Applicable Not yet recruiting 5 21 Months 4000 Béatrice Dr PARFAIT, PhD, Bénédicte Dr SAWICKI, PhD, Marie Dr COURBEBAISSE, MD, PhD, Martine Dr LOUET, PhD, Nathalie Dr DEMORY, PhD, Solen Dr KERNEIS, PhD, Véronique Dr MAHE, PhD 2020-06-12
Effect of Dinvl on improving of clinical and paraclinical symptoms in patients with COVID-19 Coronavirus disease 19 infection Dinvl herbal medicine alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zahravi drug company Iran 2020-06-20 IR.TBZMED.REC.1399.135, IRCT20200518047497N2 Phase 3 Clinical Not yet recruiting 1 80 Azizeh Farshbaf-Khalili, Javad Ahmadian Heris 2020-06-09
CONCOR-1: A Trial of Convalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness Coronavirus disease 19 infection, Respiratory disease Convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Weill Medical College of Cornell University Hamilton Health Sciences Corp US 2020-06-30 2021-12-31 20-04021981, CONCOR-1, NCT04418518 Phase 3 Clinical Not yet recruiting 2 18 Months 1200 Celine Arar, Marshall Glesby, MD, Marshall Glesby, MD, PhD 2020-06-10
PPT-COVID: Patient Preference Trial for COVID-19 Coronavirus disease 19 infection, Viral pneumonia chloroquine alone, hydroxychloroquine alone, azithromycin plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Princesse Grace Monaco 2020-04-06 2020-09-01 20-08, NCT04418193, PPT-COVID Phase Not Applicable Recruiting 1 4 Months 100 Atul PATHAK, MD PhD, Celine DUGOURD 2020-06-10
VIVALDI: COVID-19 in care homes Coronavirus disease 19 infection Baseline assessment and antibody testing alone, Intensive testing for infection (PCR and antibody) alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of London National Institute for Health Research (NIHR) UK 2020-05-28 2021-11-30 CPMS 45953, IRAS 284545, ISRCTN14447421, VIVALDI Phase Not Applicable Recruiting 2 18 Months Dr Maria Krutikov, Dr Shallcross 2020-06-10
Neuro-COVID: Neurological Complications of COVID-19 Coronavirus disease 19 infection, Neurological disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Zurich Switzerland 2020-05-01 2022-05-30 NCT04418609, NEURO-COVID-19, Neuro-COVID Phase Not Applicable Recruiting 1 24 Months 30 Emanuela Keller, Prof. Dr. 2020-06-09
COVIDOB: COVID-19 and Obstetric Transmission Coronavirus disease 19 infection RT-PCR alone, antibody testing alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University Hospitals Of Cleveland Case Western Reserve University, Cleveland Clinic Foundation, Cuyahoga County Board of Health, MetroHealth Medical Center US 2020-04-28 2021-07-31 20200479, COVIDOB, NCT04418557 Phase Not Applicable Recruiting 1 15 Months 200 Rachel Pope, Rachel Pope, MD, MPH 2020-06-10
A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer Coronavirus disease 19 infection, Viral pneumonia TL-895 alone, standard available treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Telios Pharma, Inc 2020-06-30 2021-07-31 NCT04419623, TL-895-202 Phase 1/Phase 2 Clinical Not yet recruiting 0 13 Months 146 John Mei 2020-06-10
Effect of bee products on COVID-19 Coronavirus disease 19 infection Variable regimens including N-chromosome royal jelly , honey , propolis Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-05-30 IR.SBMU.NRITLD.REC.1399.048, IRCT20200209046427N1 Phase Not Applicable Recruiting 1 60 Afshin Zarghi, Shadi Shafaghi 2020-06-15
CORDA: Covid Radiographic Images Data-set for AI Coronavirus disease 19 infection, Viral pneumonia chest x-ray radiography alone, neural network algorithm diagnosis alone Azienda Ospedaliera Citta della Salute e della Scienza di Torino Azienda Ospedaliera Ordine Mauriziano di Torino, University of Turin Italy 2020-03-24 2021-03-31 CORDA, CORDA, NCT04419545 Phase Not Applicable Recruiting 1 12 Months 2500 Andrea Ferraris, M.D., Claudio Berzovini, M.D., Francesca Santinelli, M.Sc., Giorgio Limerutti, M.D., Marco Calandri, M.D., Marco Grosso, M.Sc., Paolo Fonio, M.D., Patrizia Sardo, M.D., Simona Capello, M.D., Stefano Tibaldi, M.Sc. 2020-06-10
COVID-US: Confirmation of Ventilation and Intubation by Determination With Ultrasonography Coronavirus disease 19 infection lung ultrasonography alone, tracheal ultrasonography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Pittsburgh Baylor College of Medicine, Cleveland Clinic Foundation, Kadlec Regional Medical Center, Oregon Health Sciences University US 2019-01-01 2020-05-30 COVID-US, NCT04419064, STUDY20050011 Phase Not Applicable Completed 4 16 Months 118 Mourad H Senussi, MD, MS 2020-06-09
A phase I clinical study of EXG-5003 for the potential treatment of COVID-19 Coronavirus disease 19 infection EXG-5003 alone COVID19 Spike glycoprotein modulator Elixirgen Therapeutics Inc US Phase 1 Clinical Planned 1 2020-06-11
A clinical study to assess QuadraMune in the treatment of patients suffering from COVID-19 and/or individuals at risk of COVID-19 Coronavirus disease 19 infection QuadraMune alone Therapeutics Solutions International Inc Phase Not Applicable Planned 0 2020-06-08
A pilot clinical feasibility study to assess QuadraMune in healthy subjects in the prevention of COVID-19 Coronavirus disease 19 infection QuadraMune alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Therapeutics Solutions International Inc Phase 1 Clinical Status not specified 0 32 2020-06-08
RAS and Coagulopathy in COVID-19 Blood clotting disorder, Coronavirus disease 19 infection TRV-027 alone Angiotensin II AT-1 receptor antagonist, Beta-arrestin stimulator Aged Adults (65-79 yrs), Elderly Adults (80 and over) Imperial College London UK 2020-07-31 2021-01-31 283093, NCT04419610 Phase 0 Clinical Not yet recruiting 1 6 Months 60 DAVID OWEN, David Owen, Katrina Pollock, Lisa Hurley 2020-06-08
Living With Sickle Cell Disease in the COVID-19 Pandemic Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Sickle cell anemia, Sleep disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Human Genome Research Institute National Institutes of Health Clinical Center US 2020-06-17 2024-12-31 20-HG-N125, 999920125, NCT04417673 Phase Not Applicable Not yet recruiting 1 54 Months 700 Nathan Jones, Vence L Bonham, J.D. 2020-06-15
Retrospective examination of the course of a Covid-19 infection in patients with inflammatory bowel disease Coronavirus disease 19 infection, Inflammatory bowel disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CSG - Clinische Studien Gesellschaft GmbH Germany 2020-04-21 2020-1705-Reg, DRKS00021653 Phase Not Applicable Recruiting 1 500 Niels Teich 2020-06-08
COVID-PraxImmun: Investigation of the immune status against SARS-CoV-2 of medical professionals in Doctor's Practices in Thuringia (COVID-19 research project) Coronavirus disease 19 infection Lateral-Flow-Assay IgM/IgG alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over), European Ancestry Association of Statutory Health Insurance Physicians North Rhine Zentralinstitut für die kassenärztliche Versorgung in der Bundesrepublik Deutschland Germany 2020-06-30 22860/2020/57, COVID-PraxImmun, DRKS00021815 Phase 4 Clinical Not yet recruiting 1 10000 Anke Möckel, Thomas Schröter 2020-06-08
COVIDLight: Vielight RX Plus for the Treatment of COVID-19 Respiratory Symptoms Coronavirus disease 19 infection, Respiratory disease Vielight RX Plus alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Vielight Inc. Canada 2020-07-01 2021-01-01 COVIDLight, NCT04418505, VL-2020-02 Phase Not Applicable Not yet recruiting 1 6 Months 280 Andrea Berk, Roy Tingley, MD 2020-06-10
COVID 19-IA: CT Biomarkers Identification by Artificial Intelligence for COVID-19 Prognosis Coronavirus disease 19 infection, Lung injury deep learning artificial intelligence alone, thoracic computed tomography scan alone Centre Hospitalier Universitaire de Nimes France, Martinique 2020-03-01 2020-07-31 COVID 19-IA, NCT04418245, NIMAO/2020/COVID 19-IA/JF-01 Phase Not Applicable No longer recruiting 6 5 Months 1000 Julien Frandon 2020-06-10
Clinical Efficacy of Nafamostat Mesylate for COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia antibiotic agents therapy alone, continuous renal replacement therapy (CRRT) alone, extracorporeal membrane oxygenation (ECMO) alone, hemodialysis (HD) alone, invasive ventilation therapy alone, non-invasive ventilation therapy alone, supplemental oxygen theray alone, Variable regimens including hydroxychlorquine , lopinavir + ritonavir , nafamostat mesylate HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gyeongsang National University Hospital South Korea 2020-06-10 2021-04-30 2020-04-012, NCT04418128 Phase 2/Phase 3 Clinical Not yet recruiting 1 10 Months 84 IN-GYU BAE, MD, Kyunglan Moon, MD 2020-06-11
Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease Coronavirus disease 19 infection N-acetylcysteine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cambridge Health Alliance US 2020-06-15 2021-03-31 CHA-IRB-1139/05/20, NCT04419025 Phase 4 Clinical Not yet recruiting 1 9 Months 200 Duncan Kuhn, MD, Melisa Lai-Becker, Melisa Lai-Becker, MD 2020-06-10
A phase I clincal study to test the efficacy of Carragelose for the trearment of viral pneumonia, SARS-CoV-2 and other viruses of the respiratory tract Coronavirus disease 19 infection, Respiratory tract infection, Viral pneumonia Carragelose alone Marinomed Biotechnologie GmbH Phase 1 Clinical Planned 0 2020-06-09
Effect of Umifenovir in treatment of covid-19 Coronavirus disease 19 infection Arbidol plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tehran University of Medical Sciences Iran 2020-04-20 2020-05-25 IR.TUMS.VCR.REC.1399.204, IRCT20200523047550N1 Phase 3 Clinical Completed 1 1 Month 50 Sara Ghaderkhani 2020-06-09
A clinical trial of pritumumab for the potential treatment of COVID-19 infection Coronavirus disease 19 infection pritumumab alone Vimentin modulator Nascent Biotech Inc Phase Not Applicable Planned 0 2020-06-08
Difficulty in doing usual work after wearing personal protective equipment Coronavirus disease 19 infection Personal Protective Equipment alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) All India Institute of Medical Sciences India 2020-06-04 CTRI/2020/06/025560  Phase Not Applicable Not yet recruiting 1 50 Dr Puneet Khanna 2020-06-08
Homoeopathic Medicines Bryonia alba 30C as a Prophylaxis for COVID-19 Coronavirus disease 19 infection Bryonia alba alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Principal Aarogya Homoeopathic Medical College and Hospital Ministry of Ayush India 2020-06-15 CTRI/2020/06/025558 Phase 4 Clinical Not yet recruiting 1 300 Dr Dan Singh Meena, Prof Dr Puneet R Shah 2020-06-09
DAWN AntiCo: A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19 Coronavirus disease 19 infection Aprotinin alone, anakinra alone, enoxaparin sodium alone, nadroparin calcium alone Low molecular weight heparin, Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) UZ Leuven-University Hospitals Belgium 2020-05-20 2020-001739-28, DAWN AntiCo, S63979 Phase 2 Clinical Recruiting 1 Caroline Devooght 2020-06-08
COVID-PREVENT: Effect of Anticoagulation Therapy on Clinical Outcomes in COVID-19 Arterial thrombosis, Coronary artery disease, Coronavirus disease 19 infection, Deep vein thrombosis, Diabetes mellitus, Lung embolism, Myocardial infarction, Nicotine dependence, Stroke, Thromboembolism rivaroxaban alone Factor Xa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Charite University Bayer AG, Deutsches Zentrum für Herz-Kreislauf-Forschung Germany 2020-06-15 2021-05-30 2020-002282-33, COVID-PREVENT, COVID-PREVENT, NCT04416048 Phase 3 Clinical Not yet recruiting 27 11 Months 400 Andreas Zeiher, Prof. Dr., Aviva Raatz, Dr., Burkhard Pieske, Prof. Dr., Carsten Büning, Prof. Dr., Christiane Erley, Prof. Dr., Christoph Stellbrink, Prof. Dr., Co-PI: Andreas M. Zeiher, Prof. Dr., Co-PI: Steffen Massberg, Prof. Dr., Co-PI: Ursula Rauch-Kröhnert, Prof. Dr., Dennis Wolf, PD Dr., Fabrizio Esposito, Dr., Hans-Christian Mochmann, Dr., Hans-Heinrich Minden, Dr., Ingo Eitel, Prof. Dr., Jakob Ledwoch, Dr., Jan Beyer-Westenhoff, PD Dr., Jan Cornely, Kurt Rasche, Prof. Dr., Leonhard Bruch, Dr., Martin Witzenrath, Prof. Dr., Olaf Göing, Dr., Sebastian Schellong, Prof. Dr., Stefan Felix, Prof. Dr., Steffen Behrens, Prof. Dr., Steffen Massberg, Prof. Dr., Steffen Schön, Prof. Dr., Thomas Münzel, Prof. Dr., Tim Seidler, Prof. Dr. med., Timm Westhoff, Prof. Dr., Ulf Landmesser, Prof. Dr., Ursula Rauch-Kroehnert, Prof. Dr. med., Uta Merle, Prof. Dr. 2020-06-08
COACHING FOR COVID-19: A Pilot Study Investigating the Effectiveness of Coaching on Psychological Outcomes in Hospital-Based Senior Doctors Acute stress disorder, Coronavirus disease 19 infection coaching sessions alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) South Western Sydney Local Health Network Liverpool Hospital Australia 2020-06-05 ACTRN12620000636954p Phase Not Applicable Not yet recruiting 1 35 A/Prof Samuel Harvey, Dr Sarah Dalton, Ms Rita Holland 2020-06-14
Testing an Online Coping Skills Intervention for People Living with Chronic Illness During the COVID-19 Pandemic Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression follow-up questionnaire alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Auckland New Zealand 2020-06-08 ACTRN12620000634976p, U1111-1252-5637 Phase Not Applicable Not yet recruiting 1 46 Dr Anna Serlachius 2020-06-08
INFLAMMACOV: An open, prospective, randomized, therapeutic trial using anakinra or tocilizumab alone or in association with ruxolitinib in severe stage 2b and 3 COVID-19-associated Disease Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Viral pneumonia anakinra alone, tocilizumab (intravenous), Roche/Chugai alone, Variable regimens including anakinra , ruxolitinib , tocilizumab (intravenous), Roche/Chugai IL-6 receptor antagonist, IL-6 receptor modulator, Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor, Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Assistance Publique Hopitaux De Marseille France 2020-09-01 2022-11-01 2020-001754-21, 2020-23, INFLAMMACOV, NCT04424056 Phase 3 Clinical Not yet recruiting 2 26 Months 216 Gilles Kaplanski, Gilles Kaplanski, MD 2020-06-10
A Study of Opaganib in Coronavirus Disease 2019 Pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia opaganib alone, standard of care alone Dihydroceramide delta 4 desaturase inhibitor, Sphingosine kinase 2 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) RedHill Biopharma Ltd US 2020-06-11 2020-12-31 ABC-110, NCT04414618 Phase 2a Clinical Recruiting 2 6 Months 40 Kevin Winthrop, MD, MPH, Mark L Levitt, MD, PhD, Vered Katz Ben-Yair, MSc 2020-06-15
SAVE-ICU: Sedating With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival Anesthesia, Coronavirus disease 19 infection isoflurane alone, sevoflurane alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sunnybrook Health Sciences Centre Canada 2020-06-15 2022-06-15 2149, NCT04415060, SAVE-ICU Phase 3 Clinical Not yet recruiting 2 24 Months 752 Angela Jerath, MD, Brian Cuthbertson, MD, Claudio Martin, MD, Marat Slessarav, MD, Marat Slessarev, MD 2020-06-12
Hydroxychloroquine to Prevent SARS-CoV-2 Infection Coronavirus disease 19 infection hydroxychloroquine alone, standard personal protection measure alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidad Peruana Cayetano Heredia Peru 2020-06-30 2020-10-31 202087, 20923, NCT04414241 Phase 3 Clinical Not yet recruiting 4 4 Months 320 Aldo Lucchetti, MD, Alejandro Llanos, MD, PhD, Alonso Soto, MD, MSc, PhD, Alvaro Schwalb, MD, César Ugarte-Gil, MD, MSc, PhD, Eduardo Gotuzzo, MD, Fernando Mejia, MD, MSc, Manuel Espinoza, MD, Max Grogl, PhD, Patricia García, MD, MPH, PhD, Rosio Guerra, MD, MPH 2020-06-08
Effects of a N95 Respirator versus Cloth Mask on Exercise Capacity During Treadmill Exercise Coronavirus disease 19 infection Cloth Face Mask alone, Modified Balke Treadmill test alone, N-95 Respirator alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cleveland Clinic Foundation US 2020-06-01 2020-08-01 20-538, NCT04415879 Phase Not Applicable Recruiting 2 2 Months 20 Debasis Sahoo, Matthew Kampert 2020-06-10
COVID19 Clinical Predictors and Outcome Coronavirus disease 19 infection, Respiratory failure Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St George's University Hospitals NHS Foundation Trust St Georges University of London UK 2020-06-15 2022-04-30 2020.0115, NCT04416347 Phase Not Applicable Not yet recruiting 1 22 Months 800 Timothy D Planche, Dr. 2020-06-08
PROTECT-COVID-19: Conestat Alfa in the Prevention of Severe SARS-CoV-2 Infection in Hospitalized Patients With COVID-19 Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia conestat alfa alone, standard of care alone Complement C1s subcomponent inhibitor, Kallikrein modulator, Mannan-binding lectin serine protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Pharming Group NV, University Hospital Basel Pharming Technologies BV Switzerland 2020-06-30 2021-07-31 2020-01252, ME20OSTHOFF3, NCT04414631, PROTECT-COVID-19 Phase 2 Clinical Not yet recruiting 1 13 Months 120 Marten Trendelenburg, Prof. med, Michael Osthoff, PD Dr. med, Michael Osthoff, PD Dr. med., Parham Sendi, Prof. med., Stephan Moser, MD 2020-06-08
Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia mesenchymal stem cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Nac De Ciencias Medicas Y Nutricion Salvador Zubiran Mexico 2020-05-01 2021-05-01 NCT04416139, SCI-3354-20-21-1 Phase 2 Clinical Recruiting 1 12 Months 10 Carlos A Aguilar-Salinas, MD, Carlos Aguilar-Salinas, MD, Martin Iglesias, MD 2020-06-08
USZ BioResource COVID Coronavirus disease 19 infection blood sampling for biobank alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Zurich Switzerland 2020-04-09 2022-04-30 CTC HFV2, NCT04414657 Phase Not Applicable Recruiting 1 24 Months 500 Anja Eskat, PhD, Regina Grossmann, Dr med, Silke Ludwig, MSc 2020-06-08
COVID-19: The Role of a Private Hospital in Hong Kong Amid COVID-19 Pandemic Coronavirus disease 19 infection COVID-19 diagnostic test alone Hong Kong Sanatorium & Hospital Hong Kong 2020-05-25 2020-08-31 COVID-19, NCT04416061, RC-2020-08 Phase Not Applicable No longer recruiting 1 3 Months 2500 Jonpaul Sze Tsing Zee, MBChB 2020-06-08
ERSul study: Sulodexide in the treatment of COVID-19 Coronavirus disease 19 infection conventional treatment alone, sulodexide alone Heparin agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CLINEDEM, Mexico Alfasigma SpA Mexico 2020-04-15 2020-11-30 ERSul study, ISRCTN59048638 Phase 4 Clinical Not yet recruiting 1 7 Months 600 Dr Alejandro Jose Gonzalez Ochoa 2020-06-08
Evaluation of chloroquine blood levels Coronavirus disease 19 infection, Plasmodium vivax infection chloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Fundacao Oswaldo Cruz (Fiocruz) Brazil 2017-05-08 2017-05-08 2.044.073, CAAE 67860317.3.0000.5409, RBR-6mjqrf, U1111-1252-6561 Phase 1/Phase 2 Clinical Completed 1 32 Douglas Pinto 2020-06-09
COOPCOVID-19: Treatment of Patients With COVID-19 With Convalescent Plasma Coronavirus disease 19 infection convalescent plasma alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Faculdade de Ciências Aplicadas (FCA) da UNICAMP, Fundacao Hemocentro de Ribeirao Preto, Hospital Of Syrian Lebanese Itatiba S/C Ltd, Ministry of Science and Technology, Brazil, Sociedade Beneficente Israelita Brasileira Hospital Albert Einsten Brazil 2020-06-01 2022-05-22 COOP-COVID-19-MCTIC, COOPCOVID-19, NCT04415086 Phase 2 Clinical Recruiting 1 23 Months 120 Denivalda SG Araujo, Esper G Kallas, PhD MD, Esper G Kallás, PhD, MD, Natália B Cerqueira, Zelinda B Nakagawa, MsC, Zelinda Maria B Nakagawa 2020-06-10
ReCOVER: Evaluation of a Remote Monitoring Smartphone Application and Care Model of COVID-19 Patients in the Community (ReCOVER) Coronavirus disease 19 infection TCC-COVID mHealth solution alone, standard of care treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of New South Wales Health South Eastern Sydney Local Health District, The George Institute for International Health Australia 2020-05-20 2021-05-19 NCT04399109, PID00770, ReCOVER Phase Not Applicable Recruiting 3 12 Months 2000 Benjamin Kwan, Clarissa Susanto, Dr Sze-Yuan Ooi, Jeffrey Post, Kristen Overton, Nigel Lovell, Pamela Konecny, Richard Sullivan, Sze-Yuan Ooi 2020-06-09
Short-term Physical Function Outcomes in Severe COVID-19 Patients Admitted to ICU for Invasive Mechanical Ventilation Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal Spain 2020-05-15 2020-11-15 165/20, NCT04400461 Phase Not Applicable Recruiting 2 6 Months 50 Irene Lázaro Navarro, PT,MSc,PhD, Luís López-Gónzalez, PT, MSc, Maria Natividad Seisdedos-Nunez, PT, MSc, María-Natividad Seisdedos-Nunez, PT, MSc 2020-06-09
COVRTE-19: Low Dose Pulmonary Irradiation in Patients With COVID-19 Infection of Bad Prognosis Coronavirus disease 19 infection, Respiratory disease, Viral pneumonia low dose lung radiotherapy alone, standard support therapy alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion Hospital Provincial de Castellon Spain 2020-06-01 2021-03-31 COVRTE-19, FHPCS-20-001, NCT04414293 Phase 2 Clinical Not yet recruiting 1 10 Months 41 Carlos Ferrer Albiach, MD, Francisco Garcia Piñón, MSc 2020-06-10
EIKOS: Exploring immunological control mechanisms of SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection ELISA alone, Neutralization assay alone, cytokine release assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital of Cologne Deutsches Zentrum für Infektionsforschung Germany 2020-06-05 20-1187, DRKS00021468, EIKOS Phase Not Applicable Not yet recruiting 1 2000 Florian Klein, Henning Grüll 2020-06-06
Quality of life in COVID-19 survivors Anxiety disorder, Coronavirus disease 19 infection, Depression, Fatigue, Post traumatic stress disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Integrated Rehabilitation and Organ Failure Horn Netherlands 2020-05-07 2021-06-01 NL8587 Phase Not Applicable Recruiting 1 12 Months 500 Martijn Spruit 2020-06-09
BCG-PLUS: Enhancing the BCG-induced trained immunity response by addition of bisphosphonate or MMR vaccine: a possible preventive approach against COVID-19 Coronavirus disease 19 infection BCG alone, MMR alone, Variable regimens including BCG , MMR , bisphosphonate Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Radboud University Netherlands Organisation for Scientific Research Netherlands 2020-05-25 2020-06-08 BCG-PLUS, NL8609 Phase 2 Clinical Not yet recruiting 1 100 Priya Debisarun 2020-06-09
Oral Favipiravir for Patients with Delayed SARS-Cov-2 viral RNA Clearance Coronavirus disease 19 infection, Viral infection favipiravir alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Wuhan Huoshenshan Hospital China 2020-03-18 2020-05-12 ChiCTR2000033491 Phase 4 Clinical No longer recruiting 1 1 Month 9 Jiqiu Wen 2020-06-08
A Phase II Study to Evaluate Axatilimab for Hospitalized Patients With Respiratory Involvement Secondary to COVID-19 Coronavirus disease 19 infection, Respiratory disease Standard of care alone, axatilimab alone CSF-1 antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Syndax Pharmaceuticals Inc US 2020-05-30 2020-11-15 NCT04415073, SNDX-6352-0505 Phase 2 Clinical Recruiting 2 5 Months 186 Magdalena Mamczur-Madry, RN, BSN, MS, ACRP-CP, Michael S. Gordon, M.D., Shani Hilliard, Sue Fischer 2020-06-08
ESHAZ: Hydroxychloroquine, Azithromycin and Zinc for the treatment of SARS-Cov2 infection in Senegal. COVID-19 Coronavirus disease 19 infection azithromycin plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cheikh Anta Diop University Senegal 2020-06-01 ESHAZ, PACTR202005622389003 Phase 3 Clinical Not yet recruiting 1 384 Cheikh T. NDOUR, Roger TINE 2020-06-08
RESOLUTION: Study of LAU-7b for the Treatment of COVID-19 Disease in Adults Coronavirus disease 19 infection, Lung inflammation, Respiratory distress syndrome fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University/Laurent Pharmaceuticals alone, standard-of-care alone Nuclear factor kappa B gene modulator Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Laurent Pharmaceuticals Canada, US 2020-06-08 2021-01-15 LAU-20-01, NCT04417257, RESOLUTION Phase 2 Clinical Not yet recruiting 2 7 Months 300 Alexandria Flannery, Jean-Marie Houle, PhD, Mylene Roy, Radu Pislariu, MD, Ramy Saleh, MD, Todd Campbell Lee, MD 2020-06-08
ECHO-COVID: Echocardiography in Critically-ill Patients With COVID-19 Pneumonia Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia echocardiography alone Hôpital Ambroise Paré France 2020-05-12 2020-09-30 ECHO-COVID, NCT04414410, REDCAP19 Phase Not Applicable Recruiting 1 4 Months 1500 Antoine Vieillard-Baron, MD, PhD 2020-06-08
MODERATE I-TOMIC: Tofacitinib for Treatment of Moderate COVID-19 Coronavirus disease 19 infection, Viral pneumonia standard of care alone, tofacitinib alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Yale University US 2020-06-30 2021-03-31 2000027848, MODERATE I-TOMIC, NCT04415151 Phase 2b Clinical Not yet recruiting 1 9 Months 60 Hyung Chun, MD, Kelly Borges, MS, BS 2020-06-08
Extracellular Water in Covid-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia whole body bioimpedence system (NİCaS) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gaziosmanpasa Taksim Research and Education Hospital Turkey 2020-07-05 2021-02-20 76, NCT04416009 Phase Not Applicable Recruiting 1 7 Months 52 SİBEL BEKTAŞ, aygen türkmen, Prof.MD, zuhal çavuş, MD 2020-06-08
AntiCoV-HB: COVID-19: Seroprevalence Study of Anti SRAS-CoV-2 Antibodies in GHT Employees in Haute Bretagne Coronavirus disease 19 infection NG-Biotech test alone, blood test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rennes University Hospital Fonds Nominoë France 2020-05-29 2020-11-10 35RC20-9716, AntiCoV-HB, NCT04416308 Phase Not Applicable Recruiting 1 5 Months 13000 Agnès GAZZOLA, CHRISTOPHE PARIS, MD, Christophe PARIS, MD, RONAN GARLANTEZEC, MD, Ronan GARLANTEZEC, MD 2020-06-08
HoCoPsy: Characteristics of the Patients Hospitalized With Involuntary Commitment Procedure, in the Context COVID-19 Coronavirus disease 19 infection, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-05-01 2020-06-30 HoCoPsy, NCT04417374, RECHMPL20_0320 Phase Not Applicable No longer recruiting 1 2 Months 94 Emilie Olie, MD PhD 2020-06-06
COVILLE2: Part 2 on the Study Prevalence of SARS -Cov2 Carriage in Asymptomatic and Mildly-symptomatic Children Coronavirus disease 19 infection RT-PCR alone, Sars-Cov2 serology alone Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Centre Hospitalier Intercommunal Creteil ACTIV, France, GFRUP, GPIP (FR) 2020-06-07 2020-11-15 COVILLE2, COVILLE2, NCT04416893 Phase Not Applicable Not yet recruiting 0 5 Months 630 2020-06-08
Who Benefits More? Optimizing Mindfulness Based Interventions for Improved Psychological Outcomes Acute stress disorder, Coronavirus disease 19 infection, Sleep disorder mindfulness based intervention alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National University of Singapore Brahm Centre Singapore 2019-09-20 2022-06-30 NCT04417153, S-19-176 Phase Not Applicable Recruiting 1 33 Months 1000 Francesca Perini, PhD, Julian Lim, PhD 2020-06-10
ILIAD 7: Recombinant InterLeukin-7 (CYT107) to Improve clinical outcomes in lymphopenic pAtients with COVID-19 infection Coronavirus disease 19 infection, Lymphocytopenia CYT-107 alone IL-7 receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Revimmune Inc France 2020-05-06 2020-001573-78, 87RI20_0012, ILIAD 7 Phase 2 Clinical Recruiting 1 200 Renaud MARTIN 2020-06-06
Melatonin Immune Boost COVID 19 Study Coronavirus disease 19 infection melatonin alone Healthy volunteers accepted, Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute Of Medical Sciences, Rishikesh India 2020-06-15 CTRI/2020/06/025613 Phase 4 Clinical Not yet recruiting 1 200 Rohit Walia 2020-06-08
COVIM: COVID-19 Epidemic and Patients With Myeloproliferative Neoplasias Coronavirus disease 19 infection, Myelofibrosis, Myeloproliferative disorder, Polycythemia vera, Thrombocythemia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) French Innovative Leukemia Organisation France 2020-06-15 2020-12-31 COVIM, COVIM, NCT04416438 Phase Not Applicable Not yet recruiting 2 6 Months 50 Jean-Jacques KILADJIAN, Pr, Laurence LEGROS, Dr, Valerie ROLLAND 2020-06-08
A trial to evaluate replication-competent VSV chimeric virus-based vaccine (COVID-19), IAVI/Batavia Biosciences/Merck & Co Inc for the prevention of SARS-CoV-2 infection Coronavirus disease 19 infection replication-competent VSV chimeric virus-based vaccine (COVID-19), IAVI/Batavia Biosciences/Merck & Co Inc alone COVID19 Spike glycoprotein modulator International AIDS Vaccine Initiative Merck & Co Inc Phase Not Applicable Planned 0 2020-06-05
An observational, retropsective, single-center study to evaluate the short-term effect of risk-adapted treatment strategy on patients with COVID-19 Coronavirus disease 19 infection Chinese Academy of Sciences, University of Science & Technology of China Phase Not Applicable Status not specified 0 55 2020-06-10
RE-HCP2 COVID study: A study to determine relative efficacy of hydroxychloroquine prophylaxis to healthcare-professionals for Covid-19 mitigation Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute Of Medical Sciences, Rishikesh India 2020-06-12 CTRI/2020/06/025593, RE-HCP2 COVID study Phase Not Applicable Not yet recruiting 1 3000 Prasan Kumar Panda 2020-06-08
CovILD: Development of Interstitial Lung Disease (ILD) in Patients With Severe SARS-CoV-2 Infection (COVID-19) Coronavirus disease 19 infection, Interstitial lung disease Blood sampling alone, HRCT alone, Spirometry alone, echocardiography alone, plethysmography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medizinische Universität Innsbruck Austria 2020-04-29 2022-04-28 20200429-2255, CovILD, NCT04416100 Phase Not Applicable Recruiting 1 24 Months 130 Ivan Tancevski, Doz. Dr., Judith Löffler-Ragg, Prof. Dr. 2020-06-08
Quality of Life and Patient-centered Outcomes After UCI Admission for COVID-19 Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Porto Centro Hospitalar Lisboa Ocidental, Centro Hospitalar do Porto, Universidade Do Algarve Portugal 2020-06-15 2022-10-01 NCT04416464, QOL_ICU_COVID Phase Not Applicable Not yet recruiting 4 27 Months 230 António Sarmento, Cristina Granja, Prof., Irene Aragão, Isabel J Pereira, Lurdes Santos, Luís Filipe Azevedo, Prof., Mariana MS Santos, MSc. 2020-06-08
COVID&PREG: COVID-19 and Pregnancy Outcomes Coronavirus disease 19 infection RT PCR alone Female, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Universidade Nova De Lisboa Portugal 2020-03-22 2023-12-31 COVID&PREG, COVID&PREG, NCT04416373 Phase Not Applicable Recruiting 1 45 Months 300 Alexandra Queirós, MD, Alexandra S Queiros, MD, Ana M Campos, PhD,MD, Maria J Alves, MD, Nadia Charepe, MD,MSc, Nadia Charepe, MSc, MD, Teresa Ventura, PhD,MD 2020-06-08
Use of Herbal Medicine like Tulasi, Amruth(Giloy), Turmeric, Ashwagandha as add on treatment in COVID-19 Patients Coronavirus disease 19 infection Variable regimens including Amruth , Shakti drops , Tulsi Arka , Turmeric plus Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Sriveda Sattva PvtLtd India 2020-06-13 CTRI/2020/06/025592 Phase 4 Clinical Not yet recruiting 1 50 Dr C R Jayanthi, Dr M Ravi Kumar Reddy 2020-06-09
Clinical Characteristics of Critically Ill Patients With COVID-19 Coronavirus disease 19 infection File Scanning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nevsehir Public Hospital Turkey 2020-06-30 2020-07-25 2020-05-13T12_44_51, NCT04413435 Phase Not Applicable Recruiting 1 105 Betül Kozanhan, Dr, Mehmet Akif Yaza, Yasin Tire, Dr 2020-06-08
STOIC: Steroids in COVID-19 Study Coronavirus disease 19 infection, Respiratory disease budesonide alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oxford 2020-06-11 2020-12-30 NCT04416399, STOIC, STOIC STUDY Phase 2 Clinical Not yet recruiting 0 6 Months 478 Magda Laskawiec, Mona Bafadhel, MBBS, PhD 2020-06-10
A phase II proof of concept trial to assess efficacy of LY-CoV555 in COVID-19 vulnerable populations Coronavirus disease 19 infection LY-CoV555 alone COVID19 Spike glycoprotein modulator Eli Lilly & Co Phase 2 Clinical Planned 0 2020-06-05
Ruxolitinib in the Treatment of Covid-19 Coronavirus disease 19 infection ruxolitinib (oral, myeloproliferative disorders), Incyte/Novartis alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clinica Zabala Novartis AG Argentina 2020-06-01 2020-09-15 CZABALA, NCT04414098 Phase 2 Clinical Not yet recruiting 1 3 Months 100 Joaquin Castro, MD, Marcelo Iastrebner, MD 2020-06-08
COVIDOCRECHE: COVID-19 Infection and Transmission in Exposed, Confined and Community-based Infants Coronavirus disease 19 infection Nasopharyngeal swab test alone, Rapid detection test alone, Stool collection alone Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-06-02 2021-06-02 2020-A01540-39, APHP200587, COVIDOCRECHE, NCT04413968 Phase Not Applicable Not yet recruiting 1 12 Months 600 Eric LACHASSINNE, MD, Mohammed RAHAOUI, PM 2020-06-08
COVELEC: Protein Electrophoresis as a Tool for Complications Prediction in COVID-19 Hospitalized Patients Coronavirus disease 19 infection, Inflammatory disease serum protein electrophoresis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clinique de l'Estrée France 2020-06-15 2021-06-30 2020-A01376-33, COVELEC, COVELEC, NCT04414059 Phase Not Applicable Not yet recruiting 1 12 Months 155 Johanna MIMOUNI, Shahnaz KLOUCHE, Stephane DI MASCIO, MD, Stéphane DI MASCIO, MD 2020-06-08
Registry of Seraph-100 Microbind Affinity Blood Filter for COVID-19 Under EUA Acute lung injury, Coronavirus disease 19 infection, Dyspnea, Respiratory distress syndrome, Respiratory failure Seraph-100 Microbind Affinity Blood Filter alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cincinnati Children's Hospital Medical Center ExThera Medical LLC US 2020-05-31 2021-12-31 001-SERAPH-100 FOR SARS-COV-2, NCT04413955 Phase Not Applicable Not yet recruiting 1 19 Months 100 Erdie De Peralta, Kelli Krallman, RN 2020-06-09
CovAged: Severe Acute Respiratory Syndrome-Coronavirus-2 and Loss of Autonomy in the Elderly Autonomic nervous system disease, Coronavirus disease 19 infection Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Center of Martinique Guadeloupe, France, Martinique 2020-04-15 2023-04-15 20_RIPH3-02, CovAged, NCT04414319 Phase Not Applicable Recruiting 5 36 Months 350 Cecilia COFAIS, MD, Jérome TANGHE, MD, Laury ALLARD-SAINT-ALBIN, MD, Lidvine GODAERT, PHD, Maturin TABUE TEGUO, PHD, Moustapha DRAME, PHD, Seendy BARTHOLET, MD, Veronique ERDUAL, Véronique ERDUAL 2020-06-09
NIVISCO: Efficiency and Security of Nivolumab Therapy in Obese Individuals With COVID-19(COrona VIrus Disease) Infection Coronavirus disease 19 infection Routine standard of care alone, nivolumab alone Programmed cell death protein 1 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hospices Civils De Lyon France 2020-06-15 2021-09-15 69HCL20_0478, NCT04413838, NIVISCO Phase 2 Clinical Not yet recruiting 1 15 Months 120 Dominique DELAUNAY, Emmanuel DISSE, Emmanuel DISSE, Pr, Pr 2020-06-09
COVAC1: Clinical trial to assess the safety of a coronavirus vaccine in healthy men and women Coronavirus disease 19 infection self-amplifying RNA vaccine (im, COVID-19), Imperial College London alone COVID19 Spike glycoprotein inhibitor Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Imperial College London Medical Research Council, United Kingdom Research & Innovation UK 2020-04-01 2021-07-31 2020-001646-20, COVAC1, IRAS 279315, ISRCTN17072692 Phase 1 Clinical Recruiting 5 16 Months 320 Miss Ward, Prof Sheena McCormack 2020-06-15
ICOPE: Implementation of the Integrated Care of Older People App and ICOPE Monitor in Primary Care Coronavirus disease 19 infection Healthy volunteers accepted, Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Liege Centre Hospitalier Universitaire de Toulouse Belgium 2020-10-31 2021-11-30 GERULIEGE/SG/DSR/ICOPE, ICOPE, NCT04413877 Phase Not Applicable Not yet recruiting 1 13 Months 600 Dolores Sanchez-Rodriguez, MD PhD, Sophie Gillain, MD PhD 2020-06-05
A clinical trial to evaluate safety and efficacy of polyherbal capsule Astha-15 used as an add on therapy with standard care of therapy as an immunity booster in the suspected and COVID-19 diagnosed patients Coronavirus disease 19 infection Astha-15 alone, standard care of therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Dalmia Centre For Research & Development India 2020-06-08 CTRI/2020/06/025590, DAL/CT/001/AST/2020 Phase 3 Clinical Not yet recruiting 4 120 Dr A Gopal Rao, Dr Amulya Bhati, Dr Prastita P Kshirsagar, Dr Vinod Kumar, Mukesh Kumar 2020-06-08
Comparison of two different laryngoscopes using COVID barrier box Coronavirus disease 19 infection, General anesthesia Ambu King video laryngoscope alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) All India Institute of Medical Sciences Bhubaneswar India 2020-06-15 CTRI/2020/06/025589 Phase Not Applicable Not yet recruiting 1 60 Sangeeta Sahoo 2020-06-05
Data of patients with Corona virus disease admitted to the ICU at P.D. Hinduja Hospital, Mumbai Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) P. D. Hinduja hospital and medical research centre India 2020-06-08 CTRI/2020/06/025588 Phase Not Applicable Not yet recruiting 1 400 Dr Alex Fonseca, Dr Farhad N Kapadia 2020-06-08
SEV-Covid Trial: Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection - a randomized, control trial Coronavirus disease 19 infection Standard Treatment(STns) alone, Standard Treatment(STs) alone, oseltamivir alone Exo-alpha sialidase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences India 2020-06-15 CTRI/2020/06/025575, SEV-Covid Trial Phase 3 Clinical Not yet recruiting 1 175 Prasan Kumar Panda 2020-06-08
Effect of Ayurvedic medicine in the Prophylaxis for COVID-19 of AYUSH healthcare workers , Dept of AYUSH, TS and CCRAS- NIIMH, Hyderabad Coronavirus disease 19 infection Ayush 64 alone, Chavanprash alone, Samshamani vati alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Aayush Healthcare India 2020-06-15 CTRI/2020/06/025561 Phase 2/Phase 3 Clinical Not yet recruiting 1 500 Dr Srikanth Babu Perugu 2020-06-08
ATENEA-Co-300: ATENEA-Co-300 study Coronavirus disease 19 infection CIGB-300 alone, treatment established in the national action protocol alone Casein kinase II inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Genetic Engineering and Biotechnology Ministerio de Salud Publica Cuba 2020-06-01 ATENEA-Co-300, IG/CIGB300I/CV/2001, RPCEC00000317 Phase 1/Phase 2 Clinical Not yet recruiting 1 20 Idania Baladron Castrillo, Leticia del Rosario Cruz, Silvio Perea Rodriguez 2020-06-08
A clinical trial of InspectIR portable breathalyzer for the detection of COVID-19 infection Coronavirus disease 19 infection InspectIR portable breathalyzer alone Inspectir Systems LLC US 2020-05-27 Phase Not Applicable Recruiting 1 Dr. Gustavo Day 2020-06-05
TRAiN: Rapid-Cycle Re-Implementation of Training Facilities in Norway Coronavirus disease 19 infection access to training facility alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) The Norwegian Directorate for Health and Social Affairs University of Oslo Norway 2020-05-22 2022-05-19 NCT04406909, REK 143984, TRAiN Phase Not Applicable No longer recruiting 2 23 Months 4000 Magnus Løberg, MD PhD, Mette Kalager, MD PhD 2020-06-12
A clinical study of Ayurvedic formulations in the treatment of Mild to Moderate COVID-19 patients Coronavirus disease 19 infection Variable regimens including AYUSH-64 , Sanshamani Vati Plus , Yashtimadhu Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Council of Scientific and Industrial Research (India), Ministry of Ayush India AYUSH-CSIR-TRT-01, CTRI/2020/06/025557 Phase 2 Clinical Not yet recruiting 1 420 DR ARVIND CHOPRA, Vaidya Manohar Gundeti 2020-06-08
Acute and chronic cardiovascular and respiratory changes in COVID-19 hospitalized patients and the effect of physical rehabilitation supervised by telecommunication Coronavirus disease 19 infection physical rehabilitation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundação Universidade Federal De São Carlos, Universidade Estadual Paulista (UNESP) Brazil 2020-07-01 32134720.4.1001.5398, 4.039.688, RBR-9y32yy, U1111-1252-5187 Phase Not Applicable Not yet recruiting 1 100 Alessandro Domingues Heubel, Ariane Aparecida Viana, Emmanuel Gomes Ciolac, Renata Gonçalves Mendes 2020-06-08
A open-labelled study to assess the safety and efficacy of a clinical course of oral apabetalone in hospitalized subjects with 2019-nCoV infection Coronavirus disease 19 infection apabetalone alone APOA1 gene stimulator, Angiotensin converting enzyme 2 inhibitor, Bromodomain containing protein 2 inhibitor, Bromodomain containing protein 4 inhibitor Resverlogix Corp Phase Not Applicable Planned 0 2020-06-04
A phase Ib, proof-of-concept, randomized, double-blind, placebo-controlled clinical study to evaluate the potential of TRV-027 to treat acute lung injury contributing to acute respiratory distress syndrome (ARDS) in COVID-19 patients Acute lung injury, Adult respiratory distress syndrome, Coronavirus disease 19 infection TRV-027 alone Angiotensin II AT-1 receptor antagonist, Beta-arrestin stimulator Aged Adults (65-79 yrs), Elderly Adults (80 and over) British Heart Foundation, Imperial College London Trevena Inc Phase 1b Clinical Planned 0 60 2020-06-04
Using Homeopathic Combinations for Prevention and Treatment of Viral Fevers including COVID 19 Coronavirus disease 19 infection, Fever, Viral infection Variable regimens including Aconite 30 , Allium Cepa 30 , Arsenic Album 30 , Echinacia 0 , Eupatorium 30 , Gelsmium 30 , Influenzum 30 , Thuja 0  Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sanjay Gandhi Postgraduate Institute of Medical Sciences 2020-06-18 CTRI/2020/06/025530 Phase Not Applicable Not yet recruiting 0 10000 Dr AK Gupta, Dr Anil Agarwal, Dr Piyush Gupta 2020-06-05
SCENARIO: Prevalence of SARS-CoV-2 (COVID-19) in pregnancy and at delivery in Franconia, Germany Coronavirus disease 19 infection, Pregnancy disorder Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitatsklinikum Erlangen Germany 2020-06-02 185_20B, DRKS00022088, SCENARIO Phase Not Applicable Recruiting 1 2550 Alexander Hein 2020-06-16
Clinical trial on Immunity and antiviral for quarantine patients of COVID-19 Coronavirus disease 19 infection Amrta Karuna Syrup alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Vopec Pharmaceuticals Pvt Ltd India 2020-06-01 CT/Vopec/Amrta Karuna /2020 version 1.0, CTRI/2020/06/025527 Phase 4 Clinical Not yet recruiting 1 30 Dr Dinesh 2020-06-05
Guduchi Ghanavati as a prophylactic measure among population at high risk to SARS-CoV-2 exposure Coronavirus disease 19 infection Guduchi Ghanavati   alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) GUJARAT AYURVED UNIVERSITY India 2020-06-09 CTRI/2020/06/025525 Phase Not Applicable Not yet recruiting 3 20000 Anup Thakar, Bharat Kalsariya, Harshit Shah, Kalpesh Panara, Naresh Jain, Sweety Ruparel 2020-06-05
Can the Prediction Market Improve Predictions of COVID-19 Coronavirus disease 19 infection Prediction Market alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National University of Singapore Singapore 2020-05-15 2020-05-17 NCT04410692, SG-COVID Phase Not Applicable Completed 1 560 Teck Ho, PhD 2020-06-08
To observe the impact of Ayurveda Kwath in Healthy and Suspected persons for COVID-19 Coronavirus disease 19 infection Ayurveda Kwath alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Dr.S R.Rajasthan Ayurved University Jodhpur India 2020-06-10 CTRI/2020/06/025526 Phase Not Applicable Not yet recruiting 1 500 Prof Govind Sahay Shukla 2020-06-05
ACCESS: A clinical study of real-world monitoring of COVID-19 Vaccines Coronavirus disease 19 infection European Medicines Agency, Universiteit Utrecht Europe ACCESS Phase Not Applicable Status not specified 0 2020-06-04
A phase II, open-label, non-randomized, clinical trial of the safety and efficacy of the CovidCare app to support self-monitoring for COVID-19 symptoms in self-isolation and to determine the impacts on mental health Anxiety disorder, Coronavirus disease 19 infection, Depression CovidCare app alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Melbourne Australia 2020-06-08 ACTRN12620000640909, U1111-1251-7257 Phase 2 Clinical Not yet recruiting 1 200 A/Prof Victoria Palmer, Ms Maria Potiriadis 2020-06-09
TTCOV19: Timing of Tracheotomy in Covid-19 Patients Coronavirus disease 19 infection Early tracheotomy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sahlgrenska University Hospital Sweden 2020-06-04 2021-02-01 HBERGQUIST, NCT04412356, TTCOV19 Phase Not Applicable Recruiting 1 7 Months 180 Henrik Bergquist, Assoc Prof, Måns Eeg-Olofsson, Assoc Prof 2020-06-11
A phase III trial of bemcentinib for COVID-19 Coronavirus disease 19 infection bemcentinib alone Axl tyrosine kinase receptor inhibitor BerGenBio AS UK Phase 3 Clinical Planned 1 2020-06-04
XoGloCoV2: To study the treatment of COVID-19 with severe viral pneumonia by using purified stem cell exosomes Coronavirus disease 19 infection, Lymphocytopenia, Pulmonary fibrosis, Respiratory failure, Viral pneumonia XoGlo alone Kimera Labs University Hospital Ulm Germany 2020-04-26 2020-12-31 2020-002326-90, 89081, ISRCTN33578935, XoGloCoV2 Phase 2 Clinical Recruiting 1 8 Months 64 Prof Marion Schneider 2020-06-05
A compassionate use program of Organicell Flow for the treatment of COVID-19 infection Coronavirus disease 19 infection Organicell Flow alone Organicell Regenerative Medicine US Phase Not Applicable Status not specified 1 2020-06-04
Efficacy and Safety of Hydroxychloroquine and Favipiravir in the Treatment of Mild to Moderate COVID-19 Coronavirus disease 19 infection, Viral pneumonia favipiravir alone, Variable regimens including azithromycin , favipiravir , hydroxychloroquine RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ministry of Health of Turkey Ankara City Hospital Bilkent, Ankara Training and Research Hospital, Ankara University, Ege University Hospital (Application and Research Center), Hacettepe University, Istanbul University Faculty of Medicine, Istanbul University-Cerrahpasa, Kayseri City Hospital, Kocaeli Derince Education and Research hospital, SB Istanbul Education and Research Hospital, Sultan Abdulhamid Han Training and Research Hospital, Tepecik Training and Research Hospital, Umraniye education and research hospital Turkey 2020-05-08 2020-07-30 COVID-19-FAV, NCT04411433 Phase 3 Clinical Recruiting 1 2 Months 1000 Prof. Ates KARA, MD, Prof. Ateş KARA, MD, Prof. Ateş Kara, MD 2020-06-05
Novel COVID-19: A National Analysis Coronavirus disease 19 infection, Respiratory tract infection, Viral pneumonia Assiut University Egypt 2020-05-20 2020-06-30 NCT04413045, NOVEL COVID-19 PREVALENCE Phase Not Applicable Recruiting 1 1 Month 50 Mohamed F. Mostafa, MD 2020-06-05
COVID-19_LF: Clinical Assessment of Oral Lactoferrin as a Safe Antiviral and Immunoregulatory in Treating COVID-19 Disease Coronavirus disease 19 infection bovine apolactoferrin alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Research Center Patent Office Egyptian Military Medical Services Egypt 2020-06-01 2020-09-30 COVID-19_LF, COVID-19_LF, NCT04412395 Phase 2 Clinical Not yet recruiting 4 4 Months 516 Bassim Mohamed, PhD, Christine Gindy, B Pharm, Khaled Prince, B Pharm, Marawan Abdelbaset, PhD, Osama Azmy, MD, Rehab Hegazy, PhD, Rehab Ragab Hegazy, Wafaa Abdel Aal, MD 2020-06-05
A Study of LY-3819253 (LY-CoV555) in Participants Hospitalized for COVID-19 Coronavirus disease 19 infection LY-CoV555 alone COVID19 Spike glycoprotein modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Eli Lilly & Co AbCellera Biologics Inc US 2020-05-28 2020-08-23 17823, J2W-MC-PYAA, NCT04411628 Phase 1 Clinical Recruiting 7 2 Months 40 Mark J Mulligan, Michael L Dougan, Nadine G Rouphael, Pauline K Park, Peter Chen, W A Fischer 2020-06-12
COVID-19 HUSO: Clinical trial, randomized, open-label, to evaluate the efficacy of high-dose vitamin D in patients with COVID-19 pneumonia Coronavirus disease 19 infection, Viral pneumonia vitamin D (Thorens) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario Severo Ochoa Spain 2020-05-28 01052020, 2020-002312-43, COVID-19 HUSO Phase 3 Clinical Recruiting 1 82 Miguel Cervero 2020-06-04
CovidCare - 1: Surveillance and care for confirmed and suspected patients with COVID-19 in general practice: an observational study Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Heidelberg AOK Baden-Württemberg Germany 2020-05-05 CovidCare - 1, DRKS00022054, S-266/2020 Phase Not Applicable Recruiting 1 400 Frank Peters-Klimm, Markus Qreini 2020-06-05
A clinical trial to investigate the efficacy and safety of a new compound for the treatment of COVID-19, called BDB-001. Patients in the trial will be randomly allocated to either the new treatment or the conventional treatment and will be aware of which treatment they are receiving Coronavirus disease 19 infection, Respiratory distress syndrome BDB-1 alone Complement C5a factor inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Beijing Defengrei Biotechnology Co Ltd, Staidson (Beijing) Biopharmaceutical Co Ltd Spain, Europe 2020-05-08 2020-001671-32, Name: NMPA Number: 020L00003, STS-BDB001-04 Phase 2 Clinical No longer recruiting 1 60 Lixin Jiang 2020-06-12
BATS: Best available treatment study for inflammatory conditions associated with COVID-19 Coronavirus disease 19 infection, Inflammatory disease Imperial College London UK 2020-05-08 2022-05-31 BATS, IRAS 284825, ISRCTN69546370 Phase Not Applicable Not yet recruiting 1 24 Months 1800 Prof Levin 2020-06-05
ImmunoCorona: Evaluation of the synergistic effect of sequential administration of two immunostimulant products: Immuno-1 and Immuno-2 for the stimulation of the immune response in older adults. Exploratory study Coronavirus disease 19 infection Immuno-1 plus Immuno-2 Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Finlay Institute National Center for Biopreparations (BIOCEN) Cuba 2020-05-19 ImmunoCorona, RPCEC00000315 Phase 2 Clinical Recruiting 1 60 Dagmar Garcia Rivera, Rinaldo Puga Gomez 2020-06-04
COVIDIAB-13: Covid-19 and Diabetes in West of Algeria Coronavirus disease 19 infection, Diabetes mellitus, Lung embolism glucocorticoid therapy alone, oxygen therapy alone, Variable regimens including azithromycin , hydroxychloroquine , insulin , lopinavir + ritonavir , low molecular weight heparin , zinc sulfate HIV protease inhibitor Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Université de Tlemcen, Algeria Algeria 2020-04-01 2020-06-30 COVIDIAB-13, COVIDIAB-13, NCT04412746 Phase Not Applicable Recruiting 1 3 Months 100 ALI LOUNICI, ALI LOUNICI, Professor, Benattou ZIANE, Professor, Samia BENCHOUK, Professor 2020-06-08
VME-CORONA: VA-MENGOC-BC / COVID 19 Coronavirus disease 19 infection meningitis B (Cuba vaccine), GlaxoSmithKline/Finlay Institute alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Finlay Institute BioCubaFarma Cuba 2020-04-24 2020-06-30 RPCEC00000314, VME-CORONA, VME-CORONA Phase 2 Clinical Recruiting 1 2 Months 17000 Dagmar Garcia Rivera, Maria Toledo Romani 2020-06-09
ISACS-STEMI COVID-19: Primary Angioplasty for STEMI During COVID-19 Pandemic Acute coronary syndrome, Coronavirus disease 19 infection, Myocardial infarction Percutaneous coronary revascularization alone Universita' Degli Studi Del Piemonte Orientale "Amedeo Avogadro" Italy 2020-05-05 2020-06-02 115/20, ISACS-STEMI COVID-19, NCT04412655 Phase Not Applicable No longer recruiting 1 6609 2020-06-12
A clinical trial of nafamostat for the treatment of patients with COVID-19 infection Coronavirus disease 19 infection nafamostat (inhaled, COVID-19), University of Tokyo/ Daiichi Sankyo/ RIKEN alone Serine protease inhibitor Sun Pharmaceutical Industries Ltd India Phase Not Applicable Not yet recruiting 1 2020-06-03
A Longitudinal Study of COVID-19 Sequelae and Immunity Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institute of Allergy and Infectious Diseases National Institutes of Health Clinical Center US 2020-06-17 2027-12-31 20-I-0123, 200123, NCT04411147 Phase Not Applicable Recruiting 1 90 Months 900 Bryan P Higgins, R.N., Michael C Sneller, M.D. 2020-06-12
Epigenetic Tools as Prognostic Predictors in Covid19 Confusion, Coronavirus disease 19 infection, Hypotension, Respiratory distress syndrome, Tachycardia, Tachypnea, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Bakirkoy Dr. Sadi Konuk Research and Training Hospital Istanbul University Turkey 2020-05-21 2020-12-31 2020/143, NCT04411563 Phase Not Applicable Recruiting 2 7 Months 105 Asuman Gedikbasi, Assoc.Prof., Gokhan T Adas, Prof., Gokhan T. Adas, Prof, Gokhan T. Adas, Prof., Kadriye Yaşar, Prof., Nilgün Isiksacan, Assoc.Prof., Oya G. Hergünsel, MD, Intensivist, Sacide Pehlivan, Prof., Zafer Çukurova, Assoc.Prof. 2020-06-15
Menstrual Cycle Characteristics of Healthcare Professionals Coronavirus disease 19 infection, Dysmenorrhea, Menstruation disorder Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Haydarpasa Numune State Hospital Saglik bilimleri universtesi Turkey 2020-04-10 2020-11-10 HNEAH KAEK 2020/KK/, MINISTRY OF HEALTH, NCT04413058 Phase Not Applicable Recruiting 1 7 Months 200 Sevcan Arzu Arinkan, Sevcan Arzu Arinkan, M.D. 2020-06-04
OPTIMAL: Optimizing Outcomes With Physical Therapy Treatment for IndividuALs Surviving an ICU Admission for Covid-19 Anxiety disorder, Cognitive disorder, Coronavirus disease 19 infection, Depression, Post traumatic stress disorder ICU Recovery + Physical Therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Kentucky US 2020-05-01 2021-05-01 59097, NCT04412330, OPTIMAL Phase Not Applicable Recruiting 1 12 Months 40 Evan Cassity, MS, Kirby Mayer, DPT, PhD(c), Kirby P Mayer, PhD 2020-06-05
COVID-19 Convalescent Plasma (CCP) Transfusion Coronavirus disease 19 infection, Hypoxia, Multiple organ failure, Respiratory failure, Sepsis COVID convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Mississippi US 2020-06-01 2022-05-31 2020-0137, NCT04412486 Phase 0 Clinical Recruiting 1 24 Months 100 Gailen D Marshall, Jr., MD, PhD, Lucar Lloveras, MD, Utsav Nandi, MD, Vishnu Garla, MD 2020-06-04
COLC: COVID-19, Obesity and Lifestyle in Children Coronavirus disease 19 infection, Obesity Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Maastricht University Medical Center Netherlands 2020-05-06 2021-05-06 2020-1330, COLC, NCT04411511 Phase Not Applicable Recruiting 1 12 Months 4000 Anita CE Vreugdenhil, Anita CE Vreugdenhil, Dr., Anita CE Vreugdenhil, dr., Gabrielle L ten Velde, Drs., Judith W Lubrecht, Drs., Lisanne Arayess, Drs., Lisanne Arayess, drs. 2020-06-04
PredictCovid19: Prediction of Unfavourable Outcome in Newly Covid-19 Hospitalized Patient Coronavirus disease 19 infection RT-polymerase chain reaction alone, nasopharyngeal swab sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2019-11-11 2020-05-15 20_185, NCT04412031, PredictCovid19 Phase Not Applicable Completed 1 6 Months 802 2020-06-04
An observational clinical study of Covid-19 Analysis Exploratory Markers by RT-PCR in Blood and Urine as possible prognostic factor markers for patients with SARS-CoV-2 Coronavirus disease 19 infection RT-PCR analysis alone Hospital Universitari Quirón Dexeus Phase Not Applicable Status not specified 0 2020-06-03
A clinical trial to know the effect of Virulina along with standard treatment in covid 19 positive patients Coronavirus disease 19 infection Virulina alone, standard treatment protocol alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Natural Solutions India 2020-06-15 CTRI/2020/06/025556, PHAR/CT/VIRULINA/COVID/10052020 Phase 2 Clinical Not yet recruiting 1 30 Baburao Vikram, Dr A Gopal Rao, Dr Anil Sharma 2020-06-08
Evaluation of the efficacy and safety of a new BIOMODULIN T dosage regimen for the prevention of infections, including COVID-19, in older adults in Cuba. Confirmatory study (COVID-19) Coronavirus disease 19 infection BIOMODULIN T alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Biopreparations Center Ministerio de Salud Publica Cuba 2020-04-13 B-08-038-J05, GEC2020BMT025, RPCEC00000319 Phase 2 Clinical No longer recruiting 1 160 Comfort Macías Abraham, Luis Heredia Guerra, Mary Carmen 2020-06-04
CARED: Cholecalciferol to Improve the Outcomes of COVID-19 Patients Coronavirus disease 19 infection, Respiratory disease vitamin D alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ag Nac Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación Argentina 2020-06-15 2020-12-28 001, CARED, NCT04411446 Phase 4 Clinical Not yet recruiting 1 6 Months 1265 Carlos Tajer, MD, Felipe Inserra, MD, Javier Mariani, MD, Laura Antonietti, MD, Laura Antonietti, MD MSc, León Ferder, MD, Sebastián Maristany, MD, Walter Manucha, PhD 2020-06-05
Heberon Alfa R in COVID-19 Coronavirus disease 19 infection interferon alfa-2b follow-on biologic (intravenous), CIGB/Heber Biotec alone Interferon alpha 2 ligand Ministerio de Salud Publica Cuba 2020-03-11 2020-08-14 RPCEC00000318 Phase 4 Clinical Recruiting 7 5 Months 2005 Dr. Hubert Blas Rivero Martinez, Dr. Juan Carlos Rivero Lopez, Dr. Rafael Venegas Rodriguez, Dr. Rodolfo Emilio Dominguez Rosabal, Dr.C Julio R. Betancourt Cervantes, Dr.C. Albadio Perez Aseff, Dr.Daniel Gonzalez Rico, Dra. Lissette del Rosario Lopez Gonzalez, Dra.C Natacha Mezquia de Pedro, Ricardo Pereda Gonzalez 2020-06-16
MIIC-MI: Multi-modality Imaging and Immunophenotyping of COVID-19 Related Myocardial Injury Coronavirus disease 19 infection, Heart injury 18F-FDG alone, 68Ga-dotatate alone, CT coronary angiography alone, cardiac MRI alone, cardiac PET/MRI alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Cambridge British Heart Foundation, Cambridge University Hospitals NHS Foundation Trust, Wellcome Trust UK 2020-06-30 2021-06-30 A09565, MIIC-MI, NCT04412369 Phase Not Applicable Not yet recruiting 1 12 Months 20 Andrej Ćorović, MA MB BChir, Andrew Sage, PhD, Deepa Gopalan, MD FRCR, James HF Rudd, MD PhD FRCP FESC, Jason M Tarkin, MBBS PhD, Jason M Tarkin, MBBS, PhD, Meritxell Nus, PhD, Tian Zhao, MA MBBS PhD, Ziad Mallet, MD PhD FMedSci 2020-06-04
Study to Evaluate the Safety and Efficacy of ATYR-1923 In Patients With Severe Pneumonia Related to COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia ATYR-1923 alone Neuropilin 2 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) aTyr Pharma Inc US 2020-06-01 2020-10-31 ATYR1923-C-003, NCT04412668 Phase 2 Clinical Recruiting 2 5 Months 30 Gennyne Walker, Shambhu Aryal, MD, aTyr Pharma Clinical Research 2020-06-05
Current and Past SARS-CoV-2 Infection and COVID-19 in Healthcare Coronavirus disease 19 infection RT PCR test alone, blood sampling alone, throat swab sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Karolinska University Hospital Sweden 2020-04-23 2020-12-31 COVID-19 STUDIEN, NCT04411576 Phase Not Applicable Recruiting 1 8 Months 40000 Joakim Dillner, Joakim Dillner, MD, PhD 2020-06-05
Echocardiography in Patients With Covid-19 Coronavirus disease 19 infection echocardiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Tubingen Germany 2020-03-20 2021-12-31 COVIDECHO, NCT04412460 Phase Not Applicable Recruiting 1 21 Months 500 Harry Magunia, MD, Michael Koeppen, MD 2020-06-05
ARCHITECTS: A RCT - Safety and Efficacy of Tocilizumab - Tx of Severe COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Queens Medical Centre US 2020-06-01 2021-12-31 ARCHITECTS, NCT04412772, RA-2020-019 Phase 3 Clinical Recruiting 1 19 Months 300 May Vawer, RN, Todd Seto, MD 2020-06-08
Effect of Laris-Teucrium Polium L.and Laris-Hyssop combined herbal medicine on the prevention of covid-19 disease Coronavirus disease 19 infection Laris-Tokrium Hisspus alone, Laris-Tokrium polium alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tabriz University of Medical Sciences Iran 2020-05-09 IR.TBZMED.REC.1399.026, IRCT20200503047280N1 Phase 3 Clinical Recruiting 1 300 Mohammad samiei, Seyyed Mohammad Bagher Fazljou, Seyyed mohammad bagher fazljou 2020-06-08
Anticoagulant therapy Covid-19 Bleeding, Coronavirus disease 19 infection, Thromboembolism dalteparin sodium alone, tinzaparin sodium alone Antithrombin III, Factor IIa antagonist, Factor Xa antagonist, Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Karolinska Institutet Sweden 2020-03-06 2020-05-28 Anticoagulant therapy Covid-19, NCT04412304, THROMBOEMBOLIC EVENTS IN COVID Phase Not Applicable Completed 2 2 Months 166 Maria Cronhjort, PhD 2020-06-08
CRASH: COVID-19, Respiratory Distress and Antithrombotic Drugs in Subject's Habits Coronavirus disease 19 infection, Respiratory distress syndrome antithrombolytic therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-04-30 2020-06-30 7837, CRASH, NCT04412473 Phase Not Applicable Recruiting 1 2 Months 1000 Bernard GOICHOT, MD, Jean-Edouard TERRADE, MD, Laurine LE GOFF, MD, Saïd CHAYER, PhD, HDR, Stanislas DEMUTH, MD, Vincent CASTELAIN, MD, PhD 2020-06-05
CCC: Cardiac COVID-19 Health Care Workers Coronavirus disease 19 infection, Heart injury, Heart valve disease, Ischemic heart disease, Myocarditis, Pericarditis blood sampling alone, cardiac magnetic resonance alone, electrocardiogram alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) AORTICA Group Instituto de Investigación Biomédica de Salamanca, University Hospital of Salamanca Spain 2020-05-25 2020-07-11 CCC, CCC_2020, NCT04413071 Phase Not Applicable Recruiting 1 1 Month 100 Pedro L Sanchez, Pedro L Sanchez, MD, Pedro L Sanchez, MD, PhD, Rocio Eiros, MD 2020-06-08
Study of Standard of Care Plus Intravenous Immunoglobulin (IVIG) Compared to Standard of Care Alone in the Treatment of COVID-19 Infection Coronavirus disease 19 infection, Respiratory failure standard of Care alone, Octagam plus methylprednisolone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sharp HealthCare Octapharma AG US 2020-04-28 2020-11-30 2004902, COVID-IVIG, NCT04411667 Phase 4 Clinical Recruiting 2 7 Months 40 Adriana Valdez-Hernandez, RN, Cary Murphy, RN, George Sakoulas, MD, Katie Miller, Matthew Geriak, PharmD 2020-06-05
Effect of Using Barrier Devices for Intubation in COVID-19 Patients Coronavirus disease 19 infection aerosol box alone, transparent sheet alone Healthy volunteers accepted Kocaeli Derince Training and Research Hospital Turkey 2020-06-10 2020-06-30 2020/56, NCT04412226 Phase Not Applicable Not yet recruiting 1 13 ASIM E OZBEK, MD, ASIM ENESOZBEK 2020-06-04
Safety and Efficacy of Tofacitinib in Hospitalized Participants With COVID-19 Pneumonia Who Are Receiving Standard of Care Therapy Coronavirus disease 19 infection, Viral pneumonia standard of care alone, tofacitinib citrate (oral, inflammation), Pfizer alone JAK tyrosine kinase inhibitor, Jak1 tyrosine kinase inhibitor, Jak3 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Pfizer Inc US 2020-06-04 2020-10-18 A3921377, NCT04412252 Phase 2 Clinical Not yet recruiting 1 4 Months 240 Pfizer CT.gov Call Center 2020-06-12
Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure, Viral pneumonia Invasive mechanical ventilation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda USL di Bologna Ospedale Maggiore di Bologna Italy 2020-02-01 2020-10-30 273/2020/OSS/AUSLBO, NCT04411459 Phase Not Applicable Recruiting 18 8 Months 600 Alessandro Gatta, MD, Andrea Marudi, MD, Antonella Potalivo, MD, Chiara Capozzi, Cristiana Laici, Cristiana Simonetti, MD, Davide Colombo, MD, Emanuele Russo, MD, Federica Damiani, MD, Iacopo Cappellini, MD, Lorenzo Gamberini, Lorenzo Gamberini, MD, Maria Concetta Lanza, MD, Maurizio Fusari, MD, Mirco Leo, MD, Raffaella Papa, MD, Savino Spadaro, MD, Silvia Magnani, MD, Silvia Pareschi, MD, Tommaso Tonetti 2020-06-04
Feasibility Study of Anti-SARS-CoV-2 Plasma Transfusions in COVID-19 Patients With SRD Coronavirus disease 19 infection, Multiple organ failure, Respiratory distress syndrome, Respiratory failure, Septic shock SARS-CoV-2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ascension South East Michigan US 2020-04-07 2020-12-31 1589349, NCT04411602 Phase 1 Clinical Recruiting 3 8 Months 90 Debra J Levan, DO, Shukri David, MD, Teresa Jacobson, BS, Yulia Abidov, RN 2020-06-05
Using interferon to treat COVID-19 Coronavirus disease 19 infection interferon alpha 2a alone, interferon beta 1a alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mashhad University of Medical Sciences Iran 2020-05-23 IR.MUMS.REC.1399.219, IRCT20161206031256N3 Phase 2/Phase 3 Clinical Recruiting 1 76 Haniye Ghaffari-nazari, Maryam Khoshkui, Maryam khoshkhui, Maryam khoshkui, maryam Khoshkhui 2020-06-04
Safety and Immunogenicity Study of an Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19 Coronavirus disease 19 infection SARS-CoV-2 vaccine (inactivated/Vero cells/intramuscular, COVID-19), Institute of Medical Biology Chinese Academy of Medical Sciences alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Chinese Academy of Medical Sciences West China Second University Hospital, Yunnan Center for Disease Control and Prevention China 2020-05-15 2021-09-30 20200401, NCT04412538 Phase 1/Phase 2 Clinical Recruiting 1 16 Months 942 Qihan Li, Qihan Li, PhD, Qin Yu, Xiaoqiang Liu, Yanchun Che, Researcher 2020-06-05
Effectiveness of the combined treatment with hydroxycloroquine and azithromycin versus lopinavir/ritonavir + hydroxycloroquine in hospitalized patients with confirmed COVID-19 infection Coronavirus disease 19 infection azithromycin plus hydroxycloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Basque Health Service Spain 2020-05-29 2020-001605-23, HUA-COVID-19 Phase 4 Clinical Recruiting 1 108 Inés Pérez Francisco 2020-06-08
A Study in Patients With COVID-19 and Respiratory Distress Not Requiring Mechanical Ventilation, to Compare Standard-of-care With Anakinra and Tocilizumab Treatment The Immunomodulation-CoV Assessment (ImmCoVA) Study Coronavirus disease 19 infection, Respiratory distress syndrome anakinra alone, standard-of-care treatment alone, tocilizumab alone, Variable regimens including dalteparin sodium , paracetamol , tinzaparin sodium Antithrombin III, Factor IIa antagonist, Factor Xa antagonist, Low molecular weight heparin, Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Karolinska Institutet Karolinska University Hospital Sweden 2020-06-30 2021-02-28 2020-001748-24, NCT04412291 Phase 2 Clinical Not yet recruiting 1 8 Months 120 Jon Lampa, Jon Lampa, MD PhD, Jonas Sundén-Cullberg, MD PhD 2020-06-05
Impact of COVID-19 Pandemic on Perceived Exercise Benefits and Barriers Coronavirus disease 19 infection Online Survey alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Okan University Turkey 2020-06-01 2020-06-08 500600127, NCT04412278 Phase Not Applicable Completed 1 392 Begüm Okudan, Msc.Pt 2020-06-12
iLeukPulm: Study of Sargramostim in Patients With COVID-19 Coronavirus disease 19 infection, Hypoxia sargramostim alone, standard of care alone CSF-1 agonist, GM-CSF receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Partner Therapeutics Inc 2020-06-30 2021-01-31 NCT04411680, PTX-001-002, iLeukPulm Phase 2 Clinical Not yet recruiting 0 7 Months 60 Fiona Garner, PhD 2020-06-05
VIGIL: Use of PCR-Sars-CoV-2 in Children Coronavirus disease 19 infection PCR alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Centre Hospitalier Intercommunal Creteil ACTIV, France, Association Française de Pédiatrie Ambulatoire- AFPA, GFRUP, GPIP (FR) France 2020-06-01 2021-05-31 NCT04412317, VIGIL, VIGIL Phase Not Applicable Not yet recruiting 2 12 Months 600 Corinne LEVY, MD, Corinne Levy, MD 2020-06-04
Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury Acute lung injury, Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia CERC-002 alone, standard of care alone Tumor necrosis factor 14 ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aevi Genomic Medicine Inc, Cerecor Inc US 2020-06-09 2020-11-30 CERC-002-CVID-201, NCT04412057 Phase 2 Clinical Recruiting 2 5 Months 82 H. Jeffrey Wilkins, H. Jeffrey Wilkins, MD 2020-06-15
FRA-COVID: Frailty in Elderly Patients With COVID-19 Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-03-01 2021-03-01 FRA-COVID, FRA-COVID, NCT04412265 Phase Not Applicable Recruiting 1 12 Months 300 Giuseppe Bellelli 2020-06-10
Lung Ultrasound for Assessment of Patients With Moderate to Severe Covid-19 Coronavirus disease 19 infection, Respiratory distress syndrome lung ultrasound alone, routine care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dalarna County Council Sweden 2020-05-20 2020-12-31 LUS-COVID001, NCT04412551 Phase Not Applicable Recruiting 1 7 Months 50 Maria Hardstedt, Maria Hardstedt, MD/PhD, Maria Hårdstedt, PhD 2020-06-04
Cyclosporine in Patients With Moderate COVID-19 Coronavirus disease 19 infection ciclosporin, Novartis alone Calcineurin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Pennsylvania US 2020-06-30 2020-12-31 842998, NCT04412785 Phase 1 Clinical Not yet recruiting 1 6 Months 20 Emily Blumberg, MD, Joan Gilmore, Karen Dengel, RN 2020-06-04
NETSINCOVID: Covid-19: Possible Role of Neutrophil Extracellular Traps Coronavirus disease 19 infection electron microscopy alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Ospedaliera Universitaria Integrata Di Verona Italy 2020-06-01 2021-12-31 NCT04412382, NETS IN COVID-19, NETSINCOVID Phase Not Applicable Not yet recruiting 1 19 Months 100 CHIARA MOZZINI, MD-PhD, Chiara Mozzini, DOMENICO GIRELLI, MD-PhD 2020-06-04
PROTECT-ASUC: Covid-19 Pandemic Response Of Assessment, Endoscopy and Treatment in Acute Severe Ulcerative Colitis Coronavirus disease 19 infection, Ulcerative colitis Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hull University Teaching Hospitals NHS Trust UK 2020-05-20 2020-07-31 284030, NCT04411784, PROTECT-ASUC Phase Not Applicable No longer recruiting 1 2 Months 200 Shaji Sebastian 2020-06-04
A trial to evaluate Digid Cantisense SARS-CoV-2 Test to detect SARS-CoV-2 viruses Coronavirus disease 19 infection Digid Cantisense SARS-CoV-2 Test alone Helmholtz Zentrum fur Infektionsforschung GmbH US Phase Not Applicable Planned 1 2020-06-03
REsCue: A Randomized, Double-Blind, Placebo-Controlled, Phase II Study to Evaluate the Safety and Efficacy of Rayaldee (calcifediol) Extended-release Capsules to Treat Symptomatic Patients Infected with SARS-CoV-2 Coronavirus disease 19 infection calcifediol (oral, vitamin D insufficiency), OPKO alone OPKO Health Inc US REsCue Phase 2 Clinical Not yet recruiting 1 166 2020-06-03
Effect of Ayurvedic medicine in the Prophylaxis for COVID-19 of Police personnel Dept of AYUSH, TS and CCRAS- NIIMH, Hyderabad Coronavirus disease 19 infection Raksha Kit alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) DR BRKR GOVT AYURVEDIC MEDICAL COLLEGE India 2020-06-15 CTRI/2020/05/025493 Phase 2/Phase 3 Clinical Not yet recruiting 1 1500 Dr Madikonda Praveen kumar 2020-06-04
Mental impact of SARS Covid-19 disease outbreaks among suspects coming to AIIMS Rishikesh, their close contacts, and associated healthcare providers Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences India 2020-06-10 CTRI/2020/05/025494 Phase Not Applicable Not yet recruiting 1 3000 Prasan Kumar Panda 2020-06-04
A study to estimate drug levels in health care workers on COVID infection prophylaxis Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Norwich Clinical Services Pvt Ltd. St. John's Research Institute India 2020-05-29 COVID-19-2020-01, CTRI/2020/05/025466 Phase Not Applicable Not yet recruiting 1 24 Dr Denis Xavier MD MSc, Dr Rajeev M Patil 2020-06-05
CUR-TREATCoV2: Effect of nutritional supplement made from Haldi and Black Pepper to prevent and treat active corona virus infection Coronavirus disease 19 infection curcumin with black pepper alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Siddhivinayak Pain Relief Center GMC Baramati and rural hospital, Seth GS Medical College India 2020-05-29 CTRI/2020/05/025482, CUR-TREATCoV2 Phase Not Applicable Not yet recruiting 1 50 DrKirti S Pawar 2020-06-05
Psychological and Physical Aspect of Covid-19 Patient Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Angkatan Tentera Tuanku Mizan Malaysia 2020-05-30 55028, NMRR-20-1075-55028 Phase Not Applicable Recruiting 1 278 Dr SITI NORDIANA DOLLAH 2020-06-04
Screening of healthcare workers, Doctors and Nurses working in Covid-19 wards using a continous wearable watch device Coronavirus disease 19 infection Empatica E 4 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Tata Consultancy Services Ltd India 2020-06-10 CTRI/2020/05/025495 Phase Not Applicable Not yet recruiting 1 30 Kayapanda Mandanna 2020-06-04
KAP on COVID-19 among Social Media Users in Malaysia during CMCO Coronavirus disease 19 infection Hospital Rehabilitasi Cheras Malaysia 2020-06-01 55142, NMRR-20-1064-55142 Phase Not Applicable Status not specified 1 Dr Darmini a/p Selvan 2020-06-04
Use of Clevira in COVID19 patients Coronavirus disease 19 infection Clevira alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Apex Laboratories Pvt Ltd India 2020-06-02 CTRI/2020/05/025483 Phase 3 Clinical Not yet recruiting 1 100 Dr R Narayana Babu, Dr Ramesh Kannan 2020-06-05
NDEA COVID-19: NDEA COVID-19 Coronavirus disease 19 infection Ministry of Health, Malaysia China 2020-06-01 55031, NDEA COVID-19, NMRR-20-1060-55031 Phase Not Applicable Status not specified 1 Ms Nurhafiza binti Md Hamzah 2020-06-04
CPC: Study on the effect of Chyavanprash Lehyam as a prophylactic measure among high risk population (Health Care Workers/Containment Zone Population) exposed to COVID-19 Coronavirus disease 19 infection Chyavanprash Lehyam alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Central Council for Research in Ayurveda and Siddha India 2020-06-03 CPC, CTRI/2020/05/025484 Phase 2/Phase 3 Clinical Not yet recruiting 1 5000 Dr P V V Prasad 2020-06-05
Psychological Impact Among Patients with COVID-19, Perak Coronavirus disease 19 infection, Psychiatric disorder Hospital Raja Permaisuri Bainun Malaysia 2020-05-29 54983, NMRR-20-1053-54983 Phase Not Applicable Status not specified 1 Doctor Loo Tsui Huei 2020-06-04
Effect of Prednisolone on treatment of COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome prednisolone alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tehran University of Medical Sciences Iran 2020-03-29 IR.TUMS.VCR.REC.1399.055, IRCT20081027001411N3 Phase 2 Clinical Recruiting 3 60 Ahmadreza Jamshidi, Mahdi Mahmoudi, Mahdi Vojdanian, Maryam Edalatifard, Mohammad Abdolahi, Mohammad Ali Sahraian, Sasan Falahi 2020-06-04
A clinical trial of GC-5131A for the potential treatment COVID-19 Coronavirus disease 19 infection GC-5131A alone Immunoglobulin agonist GC Pharma 2020-07-31 Phase Not Applicable Planned 0 2020-06-05
A clinical study to assess the effect of rNAPc2 in the potential treatment of COVID-19 associated coagulopathy (CAC) and the related inflammatory response Blood clotting disorder, Coronavirus disease 19 infection AB-201, Arca Biopharma alone Factor VII antagonist, Tissue factor inhibitor ARCA Biopharma Inc 2020-12-31 Phase Not Applicable Planned 0 2020-06-03
Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients After COVID-19 in Comparison With Immunocompetent Patients Coronavirus disease 19 infection ploymerase chain reaction alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital General Universitario Gregorio Marañon Spain 2020-05-29 2021-06-30 NCT04410471, SERO-COVID19-TH Phase Not Applicable Recruiting 3 13 Months 300 Magdalena Salcedo, Magdalena Salcedo, MD PhD, Maricela Valerio, MD, Victor Fernandez Alonso, Victor Fernández, Nurse 2020-06-04
The effect of surfactant on clinical outcome of patients with COVID-19 Coronavirus disease 19 infection Beraksurf alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University of Medical Sciences Iran 2020-04-20 IR.SBMU.RETECH.REC.1399.016, IRCT20091201002804N12 Phase 3 Clinical Recruiting 1 60 Afshin Zarghi, Ali Dabbagh 2020-06-04
Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19 Coronavirus disease 19 infection, Lower respiratory tract infection merimepodib plus remdesivir COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, Inosine monophosphate dehydrogenase inhibitor, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Biosig Technologies Inc US 2020-06-30 2020-08-31 NCT04410354, VC-02-01 Phase 2 Clinical Not yet recruiting 3 2 Months 40 Andrea Natale, M.D., F.H.R.S, Andrew Badley, MD, Andrew D. Badley, Brian Metzger, M.D., MPH, Claudia Libertin, MD, Matthew Robinson, M.D.,, Robert Orenstein, DO, Study Coordinator, Zelalem Temesgen, MD 2020-06-09
OBELIX: COVID-19 Blood Pressure Endothelium Interaction Study Coronavirus disease 19 infection ambulatory blood pressure monitoring alone, electrocardiogram monitoring alone, nailbed capillaroscopy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) NHS Greater Glasgow and Clyde University of Glasgow UK 2020-06-01 2021-05-31 GN20CA245, NCT04409847, OBELIX Phase Not Applicable Not yet recruiting 1 12 Months 70 Katriona Brooksbank, Rhian M Touyz 2020-06-04
A clinical trial of AAVCOVID for the prevention of COVID-19 infection Coronavirus disease 19 infection AAVCOVID alone COVID19 Spike glycoprotein modulator Massachusetts Eye Research and Surgery Institution, Massachusetts General Hospital AveXis Inc 2020-12-31 Phase Not Applicable Planned 0 2020-06-02
Immune Response and Risk of Serious Infection to SARS-Cov2 Coronavirus disease 19 infection flow cytometry alone, routine care blood test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire Dijon France 2020-06-30 2021-05-31 GHESQUIERE AOIC 2020, NCT04410432 Phase Not Applicable Recruiting 1 11 Months 63 Thibault GHESQUIERE 2020-06-05
MICRO-COV: Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches Bacterial infection, Coronavirus disease 19 infection, Lung injury, Pseudomonas aeruginosa infection, Respiratory distress syndrome, Staphylococcus aureus infection, Streptococcus pneumoniae infection, Viral pneumonia biological sampling alone, sublingual microscopy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Zurich Switzerland 2020-04-09 2023-12-31 2020-00646, MICRO-COV, NCT04410263 Phase Not Applicable Recruiting 1 44 Months 300 Philipp Buehler, MD, Philipp K Buehler, PB, Silvio Brugger, SB 2020-06-04
PREPARE IBD: Physician Responses to Disease Flares and Patient Adaptation in Relation to Events in Inflammatory Bowel Disease During COVID-19 Pandemic Coronavirus disease 19 infection, Inflammatory bowel disease Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hull University Teaching Hospitals NHS Trust UK 2020-05-22 2020-08-31 284920, NCT04410484, PREPARE IBD Phase Not Applicable No longer recruiting 2 3 Months 1500 Shaji Sebastian 2020-06-05
P2Et Extract in the Symptomatic Treatment of Subjects With COVID-19 Adult respiratory distress syndrome, Coronavirus disease 19 infection, Hypotension, Hypoxia, Sepsis, Septic shock, Viral pneumonia Variable regimens including P2Et extract , hydroxychloroquine , lopinavir + ritonavir HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario San Ignacio Javeriana University Colombia 2020-06-30 2021-06-30 CS002-COVID19, NCT04410510 Phase 2/Phase 3 Clinical Not yet recruiting 1 12 Months 100 Angel Garcia, MD. MSc. PhD(c), Margarita Manrrique, MD, MSc 2020-06-03
Psychological Impact of the Corona Virus (SARS-CoV-2) and COVID-19 Pandemic in Individuals With Psychiatric Disorders Anxiety disorder, Coronavirus disease 19 infection, Depression, Psychiatric disorder Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical University of Graz Austria 2020-04-28 2021-04-28 32-363 EX 19/20, NCT04410835 Phase Not Applicable Recruiting 1 12 Months 1000 Eva Reininghaus, Asszo.Prof., Eva Reininghaus, Prof., Nina Dalkner, PD Dr. 2020-06-13
Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID-19 Patients Coronavirus disease 19 infection melatonin alone, usual treatment alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Baqiyatallah University of Medical Sciences Iran 2020-05-12 2020-09-25 IR.BMSU.REC.1399.039, NCT04409522 Phase 2 Clinical Recruiting 1 4 Months 55 Mohammad Sadegh Bagheri Baghdasht 2020-06-03
COVID 19 Viral Clearance Among the Infected Healthcare Workers In Assiut University Hospitals Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Assiut University Egypt 2020-06-30 2021-06-30 COVID19 AMONG HCWS, NCT04409574 Phase Not Applicable Not yet recruiting 1 12 Months 31 Azza Ezzeldin, professor, Mariam Roshdy Elkhayat, Mariam elkhayat, lecturer 2020-06-05
Pharmacy Education During Covid-19 Outbreak Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs) Damanhour University Egypt 2020-06-30 2021-09-30 EDUCATIONAL PROCESS & COVID-19, NCT04409951 Phase Not Applicable Not yet recruiting 1 15 Months 100 Noha El Bassiouny, PhD 2020-06-02
Prognosis in Pregnant With COVID-19 Coronavirus disease 19 infection Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Istanbul Bakirkoy Maternity and Children Diseases Hospital Turkey 2020-03-15 2020-05-28 MTALMACPROGNOSIS, NCT04409249 Phase Not Applicable Completed 1 2 Months 150 Merve Aldikactioglu Talmac, MD 2020-06-12
Treatment With CSL-312 in Adults With Coronavirus Disease 2019 (COVID‑19) Coronavirus disease 19 infection, Viral pneumonia garadacimab alone, standard of care alone Factor XIIa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CSL Ltd 2020-06-30 2020-12-31 CSL312_COVID-19, NCT04409509 Phase 2 Clinical Not yet recruiting 0 6 Months 124 Study Director, Trial Registration Coordinator 2020-06-04
Phase III Study to Determine if RTB-101 Reduces the Severity of COVID-19 in Older Adults Residing in Nursing Homes Coronavirus disease 19 infection dactolisib alone Phosphoinositide 3-kinase inhibitor, mTOR complex 1 inhibitor, mTOR complex 2 inhibitor Aged Adults (65-79 yrs), Elderly Adults (80 and over) resTORbio Inc Brown University School of Public Health, Genesis HealthCare System, Insight Therapeutics, LLC US 2020-05-31 2020-10-31 NCT04409327, RTB101-210 Phase 3 Clinical Recruiting 1 5 Months 550 Medical Director, Medical Monitor 2020-06-05
Whole Blood Collection From Individuals in the Convalescent Phase of SARS-CoV-2 Infection Coronavirus disease 19 infection whole blood sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical College of Wisconsin Versiti US 2020-05-31 2021-05-31 NCT04409184, PRO00037957 Phase Not Applicable Not yet recruiting 1 12 Months 50 Weiguo Cui 2020-06-04
GLYCOVID-19: Glycemia and Cardiac Function in Patients With COVID-19 Coronavirus disease 19 infection, Insulin dependent diabetes, Non-insulin dependent diabetes echocardiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Steno Diabetes Center Odense Denmark 2020-04-20 2020-11-30 GLYCOVID-19, H-20024279, NCT04410718 Phase Not Applicable Recruiting 2 7 Months 100 Andreas Andersen, Andreas Andersen, MD 2020-06-04
MOHC: Home Detox in Medication Overuse Headache (MOH) During Covid-19 Emergency Coronavirus disease 19 infection, Headache bridge therapy alone, mindfulness program alone, Variable regimens including bromazepam , indomethacin , metoclopramide , pantoprazole , prednisone Benzodiazepine receptor agonist, H+ K+ ATPase inhibitor Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fondazione IRCCS Istituto Neurologico Carlo Besta Italy 2020-06-30 2022-07-31 MOH, MOHC, NCT04410536 Phase 2 Clinical Not yet recruiting 1 25 Months 25 Licia Grazzi, MD, Renato Mantegazza, MD 2020-06-04
Povidone-Iodine Versus Essential Oil Versus Tap Water Gargling For COVID-19 Patients (GARGLES) Coronavirus disease 19 infection Listerine alone, hydrogen peroxide alone, povidone-iodine (Betadine) alone, real-time reverse transcriptase-polymerase chain reaction test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universiti Sains Islam Malaysia Universiti Kebangsaan Malaysia Medical Centre Malaysia 2020-06-15 2020-08-15 NCT04410159, USIMALAYSIA Phase 2 Clinical Not yet recruiting 1 2 Months 20 NAJMA KORI, NURUL A MOHAMED, PETRICK PERIYASAMY, WAN SHAHIDA WAN SULAIMAN 2020-06-12
Lung Function, Exercise Capacity and Health-Related Quality of Life After Severe COVID-19 Coronavirus disease 19 infection, Lower respiratory tract infection, Respiratory distress syndrome, Viral pneumonia Cardiopulmonary exercise test alone, Spirometry alone, lung function test alone Federal University of Rio Grande do Sul Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq, Federal University of Health Science of Porto Alegre, Hospital Nossa Senhora da Conceicao, Hospital de Clinicas de Porto Alegre, Instituto de Educação e Pesquisa do Hospital Moinhos de Vento, Universidado de Passo Fundo Brazil 2020-05-15 2022-08-02 2020-0169, NCT04410107 Phase Not Applicable Recruiting 5 26 Months 134 Danilo C Berton, Dr, Igor G Benedetto, Dr, Marcelo B Gazzana, Dr, Marcelo F Nogueira, Dr, Mauricio R Leite, Dr, Nathalia Mendes, Dr, Paulo JZ Teixeira, Dr, Renata D Marques, Dr 2020-06-03
COVID-PACT: Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial Arterial thrombosis, Coronavirus disease 19 infection, Deep vein thrombosis Variable regimens including clopidogrel , enoxaparin sodium , heparin Low molecular weight heparin, P2Y12 purinoceptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The TIMI Study Group US 2020-06-30 2021-05-31 2020P001404, CCCTN/TIMI COVID-PACT, COVID-PACT, NCT04409834 Phase 4 Clinical Not yet recruiting 1 11 Months 750 David A Morrow, MD, MPH, Marc S Sabatine, MD, MPH, Vivian Baird-Zars 2020-06-05
Lung Fibrotic Changes Associated With SARS-CoV-2 Infection Coronavirus disease 19 infection, Pulmonary fibrosis, Viral pneumonia chest CT alone, forced spirometry alone, plethysmography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion Incliva Spain 2020-05-21 2021-07-31 INC-CVD-2020-01, NCT04409275 Phase Not Applicable Recruiting 1 14 Months 500 Jaime Signes-Costa, Jaime Signes-Costa, MD, PhD 2020-06-12
A study to assess safety and efficacy of CT-P38 for the treatment of COVID-19 Coronavirus disease 19 infection CT-P38 alone Celltrion Healthcare Co Ltd Phase Not Applicable Planned 0 2020-06-05
DMB: A study to assess the usefulness of combination of Vitamin D, magnesium and Vitamin B12 in older COVID-19 patients Coronavirus disease 19 infection intensive care support alone, oxygen therapy alone, Variable regimens including magnesium , vitamin B12 , vitamin D Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Singapore Health Services Pte Ltd Singapore 2020-03-02 2020-05-15 CIRB 2020/2344, DMB, ISRCTN15324611 Phase Not Applicable Completed 1 2 Months 40 Dr L Ho 2020-06-03
A Study to assess CT-P27 for effective treatment for COVID-19 Coronavirus disease 19 infection CT-P27 alone Hemagglutinin modulator Celltrion Healthcare Co Ltd Phase 2b Clinical Planned 0 Ki-Sung Kwon 2020-06-02
Effects of the COVID-19 Health Emergency on Biopsychosocial Health Coronavirus disease 19 infection WHOQOL-BREF survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of New Mexico US 2020-05-07 2021-03-31 20-266, NCT04409535 Phase Not Applicable No longer recruiting 1 10 Months 500 Carla Wilhite, DOT 2020-06-03
COVID-19 PCR Test Results in Asymptomatic Pregnants Coronavirus disease 19 infection reverse transcription polymerase chain reaction alone Healthy volunteers accepted, Female Istanbul Medipol University Hospital Turkey 2020-04-10 2020-05-21 GPOLAT1, NCT04410939 Phase Not Applicable Completed 1 1 Month 179 2020-06-03
DISCONNECT-1: Dismantling Covid Induced Neutrophil Extracellular Traps Coronavirus disease 19 infection, Dyspnea, Respiratory disease dornase alfa alone Deoxyribonuclease I stimulator, Deoxyribonuclease stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Exactis Innovation Hamilton Health Sciences Corp, Hoffmann-La Roche Inc, McGill University Health Center, Research Institute of the McGill University Health Centre, Sir Mortimer B Davis Jewish General Hospital Canada 2020-06-30 2021-01-31 DISCONNECT-1, DISCONNECT-1, NCT04409925 Phase 1 Clinical Not yet recruiting 1 7 Months 25 Aya Siblini, MSc, Caroline Huynh, MD, PhD, Jonathan Spicer, MD, PhD 2020-06-12
CO-RNPC: Evaluation of Changes in Weight, Sleep, and Other Psycho-behavioral Parameters During Covid-19 Confinement in Subjects Monitored by the RNPC Network Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Grenoble France 2020-05-08 2020-10-08 38RC20.150, CO-RNPC, NCT04409197 Phase Not Applicable Recruiting 1 5 Months 4000 Jean-Louis PEPIN 2020-06-03
TRASCOV: Evaluation of Additional Treatments for COVID-19: a Randomized Trial in Niger Coronavirus disease 19 infection Variable regimens including lopinavir + ritonavir , paracetamol , vitamin C HIV protease inhibitor Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Epicentre (MSF) Centre for Medical Research and Health (Cermes), Niamey, Ministry of Public Health, Niger, Université Abdou Moumouni Niger 2020-06-01 2021-12-31 NCT04409483, TRASCOV, TRASCOV Phase 3 Clinical Not yet recruiting 1 19 Months 928 Eric Adehossi, Rebecca F Grais 2020-06-03
UroCovid: The Utility of Enhanced Pre and Post-surgical Work-out to Prevent the Spread of COVID-19 in a Large Urology Department Coronavirus disease 19 infection RT-PCR alone Fundacio Puigvert Spain 2020-03-20 2020-12-31 FUNDACIÓPUIGVERT, NCT04409899, UroCovid Phase Not Applicable Recruiting 1 9 Months 300 Alberto Breda, MD, Asier Mercadé Sanchez, MD, Carles Alonso Tarres, MD, PhD, Charo Montañes Bermudez, MD, Francesco Sanguedolce, MD, PhD, Joan Palou Redorta, Prof, Josep Balaña Lucena, MD, Maite Lopez Guerrero, MªJosé Martinez Barcina, MD, Patricia Fernandez de la Llama, MD, Patricia Fernandez-Llama, MD, PhD, Raquel Lopez Martinez, Rosalia Santos da Silva, MD, Sergi Sabaté Tenas, MD 2020-06-03
A clinical trial to evaluate the safety and efficacy of AMY-101 patient with severe ARDS due to COVID-19 pneumonia Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia AMY-101 alone Complement C3 inhibitor Male, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), European Ancestry Amyndas Pharmaceuticals Italy 2020-04-01 Phase 2 Clinical Status not specified 1 1 Prof. Antonio Risitano, Prof. Fabio Ciceri 2020-06-08
Pulmonary Optical Coherence Tomography in COVID-19 Patients Adult respiratory distress syndrome, Coronavirus disease 19 infection, Inflammatory disease, Lung embolism, Thrombosis, Viral pneumonia 5 Fr multipurpose catheter (Cordis) alone, 5Fr MP catheter alone, 6 Fr 11 cm sheath alone, Recover catheter (Hexacath) alone, Storq wire (Cordis) alone, angiography alone, contrast CT scan alone, femoral vein echo-guided puncture alone, iodinated contrast administration alone, pulmonary optical coherence tomography alone, selective pulmonary artery cannulation alone, trans-thoracic echocardiography alone, unfractionated heparin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) IRCCS San Raffaele Italy 2020-05-27 2020-06-30 NCT04410549, OCT COVID Phase 2 Clinical Recruiting 1 1 Month 10 MARCO BRUNO MARIA ANCONA, SUB INVESTIGATOR, MATTEO MONTORFANO, PRINCIPAL INVESTIGATOR, Marco Bruno Maria Ancona, Sub Investigator, Matteo Montorfano, Matteo Montorfano, PI 2020-06-05
AMPoL: Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) Coronavirus disease 19 infection CloSYS mouthwash, Rowpar Pharmaceutical Inc alone, Crest Pro-Health Multi-Protection mouthwash alone, Oral-B Mouth Sore mouthwash alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California San Francisco US 2020-07-01 2021-08-31 20-30874, AMPoL, NCT04409873, R00RG2901 Phase 2 Clinical Not yet recruiting 1 14 Months 120 Sepideh Banava, DDS, MPH, Stuart A Gansky, DrPH 2020-06-03
TRACK-COVID: Investigation of COVID-19 symptoms and potential immunity in the general population Coronavirus disease 19 infection Healthy volunteers accepted University of Cambridge Health Data Research UK, National Institute for Health Research (NIHR) UK 2020-03-27 2021-06-06 2, IRAS 283239, ISRCTN55886926, TRACK-COVID Phase Not Applicable Not yet recruiting 2 14 Months 90000 Dr Amy McMahon, Prof DiAngelantonio 2020-06-05
HBOT: Hyperbaric Oxygen Therapy in Non-ventilated COVID-19 Patients Coronavirus disease 19 infection, Respiratory insufficiency antibiotic therapy alone, bronchodilator therapy alone, hyperbaric oxygen chamber (RestorixHealth) alone, hyperbaric oxygen therapy alone, standard treatment alone, steroid therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Maimonides Medical Center US 2020-06-01 2021-03-30 120-20-ASF, HBOT, NCT04409886 Phase Not Applicable Not yet recruiting 1 9 Months 30 Gene Sobol, Ory Wiesel, MD 2020-06-15
ATTAC-19: Aggrenox To Treat Acute Covid-19 Coronavirus disease 19 infection, Hypoxia dipyridamole + acetylsalicylic acid (stroke), Boehringer alone, standard of care alone Cyclooxygenase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rutgers University Boehringer Ingelheim International GmbH US 2020-06-21 2021-12-15 ATTAC-19, NCT04410328, PRO2020001399 Phase 3 Clinical Not yet recruiting 1 17 Months 132 Amit Singla, MD, Olga Kovalenko, D, PhD, CCRC 2020-06-03
J-COVID-R: A retrospective study on serum markers in the diagnosis and differentiation of COVID-19 Coronavirus disease 19 infection, Pneumonia real time PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japanese Red Cross Medical Center Japan 2020-02-01 J-COVID-R, UMIN000040617 Phase Not Applicable Recruiting 1 200 Takehiro Izumo 2020-06-04
J-COVID-RP: Retrospective study on clinical and pathological aspects of COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japanese Red Cross Medical Center Japan 2020-02-01 J-COVID-RP, UMIN000040616 Phase Not Applicable Recruiting 1 5 Takehiro Izumo 2020-06-04
J-COVID-RT: A retrospective study on the therapeutic effect of tocilizumab on COVID-19 Coronavirus disease 19 infection tocilizumab alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japanese Red Cross Medical Center Japan 2020-02-01 J-COVID-RT, UMIN000040614 Phase Not Applicable Recruiting 1 20 Takehiro Izumo 2020-06-04
Convalescent Plasma for the Treatment of Patients With Severe COVID-19 Infection Coronavirus disease 19 infection Convalescent Plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National and Kapodistrian University of Athens Hellenic Society of Haematology Greece 2020-04-23 2021-09-15 245-14-4-20, NCT04408209 Phase 2 Clinical Recruiting 6 16 Months 60 Aikaterini Niarchou, Ioanna Charitaki, Meletios Athanasios Dimopoulos 2020-06-04
H4H-01: The effect of Alfalife in reducing low-grade inflammation Coronavirus disease 19 infection, Diabetes mellitus, Inflammatory disease, Weight gain Alfalife alone, balanced hypolipidemic and isocaloric diet intake alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Digitcal Srl Freia Farmaceutici Srl Italy 2020-01-15 2020-10-31 H4H-01, H4H-01, ISRCTN12319920 Phase Not Applicable Not yet recruiting 1 9 Months 24 Dr Lina Giuseppina Gentile, Dr Maurizio Cipolla, Prof Antonio V. Gaddi, Prof Francesco Visioli 2020-06-03
COVIDHomeless: Morbi-mortality by COVID-19 Among Homeless People in Marseille: a Cohort Study Coronavirus disease 19 infection serological test alone, virological test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille France 2020-05-28 2021-01-27 2020-32, 2020-A01398-31, COVIDHomeless, NCT04408131 Phase Not Applicable Recruiting 1 8 Months 2000 Aurelie TINLAND, PH, Jean-Olivier ARNAUD, Director 2020-06-03
COVID-19 HD: High Versus Low LMWH Dosages in Hospitalized Patients With Severe COVID-19 Pneumonia and Coagulopathy Coronavirus disease 19 infection, Thromboembolism, Viral pneumonia enoxaparin sodium biosimilar, Techdow alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Modena Italy 2020-06-30 2021-06-30 2020-001972-13, COVID-19 HD, NCT04408235 Phase 3 Clinical Not yet recruiting 1 12 Months 300 Marco Marietta, MD, Pasquale Mighali 2020-06-03
GLS-1200 Topical Nasal Spray to Prevent SARS-CoV-2 Infection (COVID-19) in Health Care Personnel Coronavirus disease 19 infection GLS-1200 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) GeneOne Life Science Inc US 2020-06-01 2020-11-30 NCT04408183, T2R-002 Phase 2 Clinical Recruiting 1 6 Months 225 Medical Monitor, Project Manager, Rupa Chowdary 2020-06-09
PISCOV: A Clinical trial to study the efficacy of pH based Integrated SARS Cov-2 Immunity in Human Subjects Coronavirus disease 19 infection sunlight exposure alone, Variable regimens including Arsenic album , Chlorpromazine , High pH diet , NBE extract concoction , Tea(Theoxanthine ) Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Siddhartha Hospital India 2020-06-07 CTRI/2020/05/025490, PISCOV, U1111-1252-7438 Phase 2/Phase 3 Clinical Recruiting 1 110 Mr Javed Khan, Sapna Agarwal, Siddharth Agarwal 2020-06-08
The effect of interferon on the treatment of covid19 patients Coronavirus disease 19 infection interferon treatment alone, treatment protocol from the Ministry of Health alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ghoum University of Medical Sciences Iran 2020-03-20 IR.MUQ.REC.1399.089, IRCT20160118026097N3 Phase 3 Clinical Recruiting 1 60 hasan adeli, jamshid vfaeemanesh 2020-06-02
Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection Coronavirus disease 19 infection ivermectin alone, standard care alone, doxycycline hyclate plus ivermectin Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) International Centre For Diarrhoeal Disease Research, Bangladesh Bangladesh 2020-06-30 2020-07-31 NCT04407130, PR-20039 Phase 2 Clinical Not yet recruiting 1 1 Month 72 Wasif Ali Khan, MBBS, MHS, Wasif Ali Khan, MBBS,MHS 2020-06-10
The efficacy of Homeopathic medicines in the prevention of COVID-19 in Quarantined or Exposed Individuals Coronavirus disease 19 infection Variable regimens including Arsenic Album , Bryonia alba , Camphora , Coronavirus related nosodes Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Life Force Foundation Trust India 2020-06-08 CTRI/2020/05/025491 Phase 2 Clinical Not yet recruiting 1 1000 Dr Rajesh Shah 2020-06-02
Epidemiology of Acute Kidney Injury in COVID19 Disease in United Kingdom Coronavirus disease 19 infection, Renal injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospitals Of Derby and Burton NHS Foundation Trust UK 2020-06-01 2021-05-21 NCT04407156, UHDB/2020/050 Phase Not Applicable Not yet recruiting 1 11 Months 350 Nitin V Kolhe, MD 2020-06-02
Covid-Simile study: Homeopathy for Covid-19 in primary care Coronavirus disease 19 infection Natrum muriaticum LM2 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundação Universidade Federal De São Carlos, HN-Cristiano Homeopatia Brazil, South America 2020-06-15 2020-12-20 Covid-Simile study, UMIN000040602 Phase 2 Clinical Not yet recruiting 1 6 Months 100 Ubiratan Adler 2020-06-03
A clinical trial of ORP-100S for the treatment of COVID-19 infection Coronavirus disease 19 infection ORP-100 alone Thioredoxin stimulator OrPro Therapeutics Inc Phase Not Applicable Planned 0 2020-06-01
Asymptomatic COVID-19 Coronavirus disease 19 infection Hospital Tengku Ampuan Afzan Malaysia 2020-05-27 2020-06-27 55001, NMRR-20-1050-55001 Phase Not Applicable Status not specified 1 1 Month 100 Dr WONG YEN SHEN 2020-06-03
postICU-COVID19: postICU-COVID19 Coronavirus disease 19 infection, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Kuala Lumpur Malaysia 2020-05-26 2020-08-31 54967, NMRR-20-1049-54967, postICU-COVID19 Phase Not Applicable Recruiting 1 3 Months 10 Dr Lim Hong Tak 2020-06-03
Clinical clues and management of suspected COVID-19 Coronavirus disease 19 infection Tuanku Jaafar Hospital Malaysia 2020-05-24 2020-05-27 55109, NMRR-20-1045-55109 Phase Not Applicable Completed 1 500 Dr. Poh Kok Wei 2020-06-03
COVID-19 Selangor: COVID-19 Selangor Coronavirus disease 19 infection JABATAN KESIHATAN NEGERI SELANGOR Malaysia 2020-06-01 2020-06-30 54912, C19Sel2020 v1.1, COVID-19 Selangor, NMRR-20-1043-54912 Phase Not Applicable Status not specified 2 1 Month Dr Anita Suleiman 2020-06-03
Evolution of the efficacy and safety of Dexamethasone administration in COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome fluid therapy alone, oxygen therapy alone, dexamethasone (Abouraihan Pharmaceutical Company) plus lopinavir/ritonavir (Hetered Pharmaceutical Company, India) Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-04-24 IR.SBMU.NRITLD.REC.1399.071, IRCT20151227025726N17 Phase 2/Phase 3 Clinical No longer recruiting 1 48 Farzaneh Dastan, Payam Tabarsi, Seyed Mohammadreza Hashemian, Zahra Mirshafiei Langari 2020-06-04
ILIAD-7-FR: Interleukin-7 to Improve Clinical Outcomes in Lymphopenic patients With COVID-19 Infection FR BL Cohort Coronavirus disease 19 infection, Lymphocytopenia, Respiratory failure CYT-107 alone IL-7 receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) RevImmune SAS France Amarex Clinical Research, University Hospital, Limoges France 2020-06-01 2020-12-30 CLI107 COVID FR (ILIAD-7-FR), ILIAD-7-FR, NCT04407689 Phase 2 Clinical Not yet recruiting 2 6 Months 48 Bruno François, MD, Frederique Berbille, MHSc, Michel Morre, DVM MSc 2020-06-03
COVID-19: IMPROVISE: COVID-19: IMPROVISE Coronavirus disease 19 infection National Institutes of Health Malaysia Malaysia 2020-05-29 2020-07-31 54936, COVID-19: IMPROVISE, NMRR-20-1040-54936 Phase Not Applicable Not yet recruiting 1 2 Months Mr. HING YEE LIANG 2020-06-03
VIVI: Vienna Versus SARS-CoV-2 Virus Study Coronavirus disease 19 infection Healthy volunteers accepted Medical University of Vienna Austria 2020-05-27 2021-06-27 EK 1387/2020, NCT04407429, VIVI Phase Not Applicable Recruiting 2 13 Months 12000 Christian Hengstenberg, Univ.-Prof., Christian Nitsche, Dr., Christoph Binder, Prof., Daniela Gompelmann, Prof., Eva Schernhammer, Prof., Marco Idzko, Prof., Martin Riesenhuber, Dr., Rainer Oberbauer, Prof., Tanja Stamm, Prof., Thomas A Zelniker, DDr., Thomas Perkmann, Dr. 2020-06-03
PEP-Q: Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19 Coronavirus disease 19 infection home quarantine alone, hydroxychloroquine alone, personal hygiene alone, post exposure prophylaxis alone, social distancing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Postgraduate Institute of Medical Education and Research India 2020-03-01 2020-06-30 IEC-04/2020-1624, NCT04408456, PEP-Q Phase 3 Clinical Recruiting 1 4 Months 200 Deba P Dhibar, MD, Deba Prasad Dhibar, 2020-06-03
Outpatient Clinic in Obesity Care During COVID-19 Outbreak: Physically Far, Virtually Near Coronavirus disease 19 infection, Obesity Medical counselling alone, Telemedicine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Campania Luigi Vanvitelli Italy 2020-03-03 2020-05-04 NCT04407663, TELEMEDICINE Phase Not Applicable Completed 1 2 Months 138 Claudio Gambardella, Researcher 2020-06-02
Clinical trial study of the therapeutic effect of ivermectin, besides Kaletra and chloroquine in patients with Coronavirus disease 2019 (COVID-19) Coronavirus disease 19 infection Variable regimens including chloroquine , ivermectin , lopinavir + ritonavir Chloride channel modulator, HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ahvaz University of Medical Sciences Iran 2020-05-30 IR.AJUMS.REC.1399.194, IRCT20200422047168N2 Phase 2/Phase 3 Clinical Recruiting 1 60 Ahvaz University of Medical Sciences, Ali akbar Shayesteh, Zahra Shokati 2020-06-02
Stem cell therapy in Covid-19 Coronavirus disease 19 infection, Respiratory distress syndrome allogenic mesenchymal stem cell-derived umbilical cord transplantation alone, other common treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Mashhad University of Medical Sciences Iran 2020-06-14 IR.MUMS.REC.1399.150, IRCT20160809029275N1 Phase 2/Phase 3 Clinical Not yet recruiting 1 20 Dr.Mahnaz Amini, Seyad Jalil Tavakol Afshari 2020-06-02
APRONOX: Awake Prone Positioning and Oxygen Therapy in Patients With COVID-19 Coronavirus disease 19 infection awake prone positioning alone, oxygen therapy alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital General San Juan del Rio Mexico 2020-05-01 2020-07-30 1178/SESEQ-HSGJR/08-05-20/UTI, APRONOX, NCT04407468 Phase Not Applicable Recruiting 6 2 Months 368 Cesar Alonso Bello, MD, Cesar Alonso Bello, MD, MSc, Ernesto Deloya Tomas, MD, Ernesto Deloya Tomas, MD, MSc, Gabiel Cruz Sanchez, MD, Gabriel Cruz Sanchez, MD, Karen P Pozo Cortes, MD, Luis Macias Garcia, MD, Luis Macias, Garcia, Orlando Perez Nieto, MD, Orlando R Perez Nieto, MD 2020-06-02
Effects of licorice in treatment of COVID-19 Coronavirus disease 19 infection hydroxychloroquine sulfate plus licorice Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bandare-abbas University of Medical Sciences Iran 2020-05-21 IR.HUMS.REC.1399.066, IRCT20200506047323N2 Phase 3 Clinical Recruiting 1 60 Mohammad Fathalipour, Parivash Davoodian 2020-06-02
PS-COVID: Peer support training for adolescents during the COVID-19 outbreak Coronavirus disease 19 infection Peer Support Training alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs) University of Oxford UK 2020-04-01 2020-07-10 ISRCTN99248812, PS-COVID, R69810/RE001 Phase Not Applicable Recruiting 2 3 Months 100 Dr Pavarini 2020-06-01