Last updated: Jun 20, 2020 - 02:00 BST

Title Indication Intervention Actions PatientSelection Sponsor Collaborator Country StartDate EndDate Identifiers Phase Recruitment Status Sites Trial Duration Enrollment Count Contacts LastChanged
A clinical trial of anti-SARS-CoV2 antibodies (COVID-19 infection), Yumab for the potential treatment of COVID-19 infection Coronavirus disease 19 infection anti-SARS-CoV2 antibodies (COVID-19 infection), Yumab alone Corat Therapeutics GmbH, Yumab 2020-12-31 Phase Not Applicable Planned 0 2020-06-19
SEARCH: A large-scale study to better understand the spread and prevalence of the coronavirus in the local community, with an initial focus on evaluating healthcare workers and first responders Coronavirus disease 19 infection Rady Children's Hospital, San Diego, Scripps Research Institute, University of California San Diego US SEARCH Phase Not Applicable Status not specified 0 10000 Gene Yeo, Kristian Andersen, Lauge Farnaes, Louise Laurent, Rob Knight 2020-06-19
The Health Crisis at the Healthcare Professionals, Careers and Non-careers, a Month After the Containment Period Anxiety disorder, Coronavirus disease 19 infection, Depression Clinique Medipole Garonne 2020-06-15 2020-06-28 DECOVID, NCT04436861 Phase Not Applicable Not yet recruiting 0 200 Laurence Culine, Myaro Nodjialem 2020-06-19
A clinical trial of REGN-CoV2 for the treatment of COVID-19 patients (both those who are hospitalized and those who are not) Coronavirus disease 19 infection REGN-CoV2 alone Regeneron Pharmaceuticals Inc, University of Maryland Medical Center Phase Not Applicable Recruiting 0 2020-06-19
REACT: Rehabilitation Needs After COVID-19 Hospital Treatment Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Unita Sanitaria Locale di Reggio Emilia Italy 2020-06-30 2020-12-31 428/2020/OSS/AUSLRE, NCT04438239, REACT Phase Not Applicable Not yet recruiting 1 6 Months 100 Stefania Costi, PhD, Stefania Fugazzaro, MD 2020-06-19
Open-label, placebo-controlled, multicenter, clinical trial to assess the effect and safety of Favipiravir compared to standard care in the management of adult patients with moderate Covid-19 at risk of serious complications Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Hospital Regional de Alta Especialidad de Ixtapaluca Mexico C32-20 Phase 3 Clinical Status not specified 1 200 2020-06-19
Efficacy of Intravenous Infusions of Stem Cells in the Treatment of COVID-19 Patients Coronavirus disease 19 infection, Lung inflammation standard of care alone, Variable regimens including collagenase , fetal bovine serum (FBS) , penicillin , streptomycin , umbilical cord-derived mesenchymal stem cells Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Jinnah Hospital Johns Hopkins University Pakistan 2020-06-01 2021-06-30 JB and RSC-01, NCT04437823 Phase 2 Clinical Recruiting 1 13 Months 20 Azra Mehmood, PhD, Moazzam N Tarar, MBBS, FCPS, Mohsin Shahzad, PhD, Prof. Sheikh Riazuddin, Sheikh Riazuddin, PhD 2020-06-19
Niclosamide In Moderate COVID-19 Coronavirus disease 19 infection, Gastrointestinal disease, Viral pneumonia Standard of care therapy alone, niclosamide alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) First Wave Bio, Inc 2020-08-31 2021-02-28 FW-COV-002, NCT04436458 Phase 2 Clinical Not yet recruiting 0 6 Months 100 Tony Opipari, M.D. 2020-06-19
IBOC: Immune Biomarkers of Outcome From COVID-19 Coronavirus disease 19 infection, Immune disorder Peripheral blood sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Plymouth NHS Trust UK 2020-04-29 2020-10-28 20/HEP/381, IBOC, NCT04436484 Phase Not Applicable Recruiting 2 6 Months 200 Ashwin D Dhanda, MRCP PhD, Christopher Rollinson 2020-06-19
Treatment of COVID-19 with the inhalation drug pulmozyme Coronavirus disease 19 infection, Respiratory disease dornase alfa alone Deoxyribonuclease I stimulator, Deoxyribonuclease stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Region Skane Sweden 2020-05-18 2020-001849-39, NETs-C19 Phase 2 Clinical Recruiting 1 Adam Linder 2020-06-19
Evaluating the Efficacy of Convalescent Plasma in Symptomatic Outpatients Infected With COVID-19 Coronavirus disease 19 infection convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Metro Infectious Disease Consultants US 2020-07-06 2021-07-06 MIDC-CCP, NCT04438057 Phase 2 Clinical Not yet recruiting 1 12 Months 150 Nathan Skorodin, PharmD, Nicholas Van Hise, PharmD 2020-06-19
Study evaluating the impact of BCG vaccination on the incidence and course of SARS-CoV-2 infection among health care workers in Poland during the COVID-19 pandemic Coronavirus disease 19 infection BCG vaccine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Rzeszów Medical Research Agency (Agencja Badań Medycznych) Poland 2020-06-26 2020-002111-22, BCG/COVID-19/UR/04/2020 Phase 3 Clinical Recruiting 1 National Study Coordinator 2020-06-19
A study to assess human monoclonal antibodies (Covid-19) in the treatment of patients infected with SARS-CoV-2 Coronavirus disease 19 infection human monoclonal antibodies (Covid-19), Garvan Institute/The Kirby Institute alone COVID19 Spike glycoprotein modulator The Kirby Institute (Affiliated With The University Of New South Wales) Australia Phase Not Applicable Planned 1 Professor Daniel Christ 2020-06-19
Edaravone in COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia edaravone, Zist Daru Co alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tabriz University of Medical Sciences Iran 2020-06-21 IR.TBZMED.REC.1399.128, IRCT20200317046797N6 Phase 3 Clinical Not yet recruiting 1 30 Dr Mohammad Samiei, Mohammadreza Ardalan, Mojtaba Varshochi, Sepideh Zununi Vahed 2020-06-19
Evaluation of Vaginal Fluid for Covid-19 Positivity in Women With Positive nasopharyngeal Covid-19 Test Coronavirus disease 19 infection vginal fluid Covid-19 PCR test alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Acibadem University Turkey 2020-06-15 2020-07-30 ACIBADEM MASLAK OB&GYN, NCT04437940 Phase Not Applicable Recruiting 1 1 Month 35 Burak Celik, Eren Kaya, MD, Ozguc Takmaz, Ozguc Takmaz, Assist. Prof., Ozguc Takmaz, MD,Assist.Prof 2020-06-19
Snowball: Network-Targeted Strategies for Efficient Community SARS-CoV-2 (COVID-19) Sampling Coronavirus disease 19 infection COVID-19 testing alone, network targeted sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Duke University US 2020-07-01 2021-06-30 NCT04437706, PRO00105430, Snowball Phase Not Applicable Not yet recruiting 0 12 Months 200 Erich Huang, MD, PhD, Margaret K Pendzich, MSPH, Margaret Pendzich, Pedro Gomez, MS 2020-06-19
A phase I study of PDS-0204 for the prevention of COVID-19 infection Coronavirus disease 19 infection PDS-0204 alone Farmacore Biotecnologia Limitada, PDS Biotechnology Corp Ministry of Science and Technology, Brazil Brazil Phase 1 Clinical Planned 1 2020-06-19
A Clinical study of prophylactic vaccine (Memopi, COVID-19), OSE Immunotherapeutics in COVID-19 Coronavirus disease 19 infection prophylactic vaccine (Memopi, COVID-19), OSE Immunotherapeutics alone OSE Immunotherapeutics 2020-12-31 Phase Not Applicable Planned 0 2020-06-19
A Study of Ad26-COVS1 in Adults (COVID-19) Coronavirus disease 19 infection JNJ-78436735 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Janssen Vaccines & Prevention BV Belgium, US 2020-07-13 2023-07-08 2020-001483-28, CR108828, NCT04436276, VAC31518COV1001 Phase 1/Phase 2 Clinical Not yet recruiting 12 35 Months 1045 Janssen Vaccines & Prevention B.V. Clinical Trial, Study Contact 2020-06-19
Double-blind, placebo-controlled clinical trial of the use of colchicine for the management of patients with mild and severe SARS-Cov2 infection Coronavirus disease 19 infection colchicine alone Instituto Nacional de Ciencias Medicas y Nutricion Mexico 3374 Phase 2 Clinical Status not specified 1 2020-06-19
NICCAM: A study to investigate the safety and efficacy of two approved drugs, niclosamide and camostat, administered alone and in combination and compared to placebo in COVID-19 patients Coronavirus disease 19 infection Niclosamide plus camostat mesylate Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Charite Research Organisation Bayer AG Germany 2020-06-17 2020-002233-15, NICCAM, NICCAM-001 Phase 2 Clinical Recruiting 1 72 Kristin Herzog 2020-06-19
Effect of Interferential Therapy on SARS-CoV-2. COVID-19 Coronavirus disease 19 infection SABA alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lagos State University Teaching Hospital Nigeria 2020-10-01 PACTR202006717277937 Phase 2 Clinical Not yet recruiting 1 48 Bashir Kaka, Eniola Awolola, Sonill Maharaj 2020-06-19
A randomized, double-blind, placebo-controlled, multi-national, phase II/III clinical study to evaluate efficacy and safety of PTC-299 for the treatment of COVID-19 Coronavirus disease 19 infection PTC-299 alone Dihydroorotate dehydrogenase inhibitor, IL-6 receptor antagonist, VEGF receptor antagonist PTC Therapeutics Inc Spain, Australia, Europe, Brazil, US Phase 2/Phase 3 Clinical Not yet recruiting 4 380 2020-06-19
An Open Study of the Safety, Tolerability and Immunogenicity of the Drug 'Gam-COVID-Vac' Vaccine Coronavirus disease 19 infection Gam-COVID-Vac alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Gamalei Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation Collaborator Accellena Research and Development Russian Federation 2020-06-17 2020-08-15 02-GAM-COVID-VAC-2020, NCT04436471 Phase 1/Phase 2 Clinical Recruiting 1 1 Month 38 Inna Dolzhikova, PhD, Irina Gagarina, MD 2020-06-19
Study of vascular complications in critically ill patients with coronavirus Coronavirus disease 19 infection, Vascular disease analgesics alone, antibiotics alone, heparin alone Universidade Federal de Sao Paulo - UNIFESP Brazil 2020-04-17 3.976.579, 30667020.5.0000.5505, RBR-4qjzh7, U1111-1252-1318 Phase Not Applicable No longer recruiting 1 Luis CU Nakano, Ronald LG Flumignan 2020-06-19
Treatment of severe cases of Covid-19 with eculizumab Coronavirus disease 19 infection eculizumab alone Complement C5 factor inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital das Clinicas de Ribeirao Preto/USP Brazil 2020-05-27 30522020.0.0000.5440, 4.003.844, A10741034670, RBR-876qb5 Phase 1/Phase 2 Clinical Recruiting 1 10 Bruno Garcia Pires, Rodrigo Tocantins Calado 2020-06-19
A medical records based study for the preliminary efficacy of Tocilizumab in the treatment of the patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia tocilizumab alone Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Wuhan Huoshenshan Hospital, Xijing Hospital Shaanxi Provincial Science and Technology Department China 2020-02-27 2020-03-14 ChiCTR2000033705 Phase 4 Clinical No longer recruiting 1 61 Xijing Zhang 2020-06-19
COV-EAT: Dietary and Lifestyle Habits During the Pandemic of COVID-19 in Greece Coronavirus disease 19 infection Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) University of Thessaly Greece 2020-04-30 2020-05-24 COV-EAT, COV-EAT, NCT04437121 Phase Not Applicable Completed 1 397 Odysseas Androutsos, M.Med.Sci., Ph.D. 2020-06-19
A phase I study to assess the effect of human FGF-1 (long-term subcutaneous formulation, Parkinson's disease), Zhittya Genesis Medicine in patients with lung damage from COVID-19 Coronavirus disease 19 infection, Lung injury human fibroblast growth factor-1 (long-term subcutaneous formulation, Parkinson's disease/amyotrophic lateral sclerosis), Zhittya Genesis Medicine alone FGF-1 ligand Zhittya Genesis Medicine Inc Phase 1 Clinical Planned 0 2020-06-19
A case study on COVID-19 infection and treatment with hydroxychloroquine cause severe hemolysis crisis in a patient with glucose 6 phosphate dehydrogenase deficiency Coronavirus disease 19 infection, Enzyme deficiency hydroxychloroquine alone Geneva University Hospitals Phase Not Applicable Status not specified 0 1 2020-06-19
A phase I study to assess the effect of human FGF-1 (long-term subcutaneous formulation, Parkinson's disease), Zhittya Genesis Medicine in patients with COVID-19 lung damage Coronavirus disease 19 infection, Lung injury human fibroblast growth factor-1 (long-term subcutaneous formulation, Parkinson's disease/amyotrophic lateral sclerosis), Zhittya Genesis Medicine alone FGF-1 ligand Zhittya Genesis Medicine Inc Mexico Phase 1 Clinical Planned 1 2020-06-19
Postpartum Depression in the Covid-19 Pandemic and the Impact of Anesthesia Anxiety disorder, Coronavirus disease 19 infection, Postnatal depression 38 questions questionnaire alone, EPDS (Edinburgh Postnatal Depression Scale) alone, GAD-7 (General Anxiety Disorder) scale alone, PHQ-9 (Patient Health Questionnaire) Depression Scale alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) General and Maternity Hospital of Athens Elena Venizelou Alexandra Hospital, Larissa University Hospital, National and Kapodistrian University of Athens, University of Ioannina Greece 2020-06-30 2020-09-30 COVID-19 POSTPARTUM DEPRESSION, NCT04437342 Phase Not Applicable Not yet recruiting 6 3 Months 300 Chrysoula Staikou, Associate Professor, Dimitrios Valsamidis, Head of Department, Eleni Arnaoutoglou, Eleni Arnaoutoglou, Professor, Georgia Micha, PhD, Konstantinos Kotsis, Konstantinos Kotsis, Assistant Professor, Petros Tzimas, Petros Tzimas, Associate Professor 2020-06-19
The mechanism of PECAM-1 in mediating pulmonary vascular endothelial permeability through Wnt/beta-catenin signaling pathway in SARS-CoV-2-related ARDS Adult respiratory distress syndrome, Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The First Affiliated Hospital of Guangzhou Medical College China 2020-07-01 2020-08-31 ChiCTR2000033699 Phase Not Applicable Not yet recruiting 1 2 Months 20 Xiaoqing Liu, Zhihui Zhang 2020-06-19
An investigator-initiated, Phase IIa, randomized, double-blind, placebo-controlled trial to assess safety and efficacy of ATI-450 in hospitalized patients with COVID-19 Coronavirus disease 19 infection ATI-450 alone Adapter molecule crk inhibitor, MAPKAPK2 inhibitor University of Kansas Medical Center Aclaris Therapeutics Inc US Phase 2a Clinical Not yet recruiting 1 36 Deepika Polineni, M.D., M.P.H, Gregory Gan, M.D., Ph.D 2020-06-19
A open-label study to target the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia- case-series Coronavirus disease 19 infection, Pneumonia anakinra alone Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Caen University Hospital Phase 2 Clinical Status not specified 0 9 2020-06-19
A clinical validation study to evaluate VaxArray Coronavirus SeroAssay for the diagnosis of COVID-19 Coronavirus disease 19 infection VaxArray coronavirus seroassay alone InDevR LLC Children's Hospital Colorado Phase Not Applicable Status not specified 0 100 2020-06-19
Effectiveness of borage based solutions in cytokine's levels in covid-19 ARDS patients Adult respiratory distress syndrome, Coronavirus disease 19 infection Borage suspension therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University of Medical Sciences, Laser Application in Medical Sciences Research Center Iran 2020-03-20 IR.SBMU.NRITLD.REC.1399.059, IRCT20150107020592N28 Phase 3 Clinical Recruiting 1 50 Seyed Mohammad Reza Hashemian, Seyyed Mohammadreza Hashemian 2020-06-19
To describe the case of a critically-ill patient with myocarditis and severe ARDS related to COVID-19 infection: A case-study Coronavirus disease 19 infection, Myocarditis, Respiratory distress syndrome AT-001 alone, fraction of inspired oxygen alone, milrinone alone, neuromuscular blockade alone, positive end-expiratory pressure alone, tocilizumab alone, Variable regimens including colchicine , methylprednisolone , prednisone PDE 3 inhibitor Male Advocate Illinois Masonic Medical Center Phase Not Applicable Status not specified 0 1 2020-06-19
A phase I/IIa study of GX-19 in COVID-19 Coronavirus disease 19 infection GX-19 alone Healthy volunteers accepted Genexine Co Ltd South Korea Phase 1/Phase 2 Clinical Planned 1 190 2020-06-19
USCovid: Reliability of a Pocket Sized Ultrasound Scanner in the Evaluation Covid-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia LUS (lung ultrasound scan) alone, pocket-sized ultrasound scanner (Butterfly Network Inc., Butterfly iQ) alone, ultrasound scanner (GE Healthcare, Venue GO) alone University of Siena Italy 2020-03-15 2020-06-10 NCT04433000, USCOVID, USCovid Phase Not Applicable Recruiting 1 2 Months 34 David Bennett, MD, Piersante Sestini, MD, Sestini Piersante, MD 2020-06-19
A case-series study to follow the clinical course of COVID-19 in patients with systemic lupus erythematosus (SLE) who received long-term treatment with hydroxychloroquine: a case-series Coronavirus disease 19 infection hydroxychloroquine alone, invasive mechanical ventilation alone, oxygen therapy alone, prednisone alone Sorbonne Universites Phase Not Applicable Status not specified 0 17 2020-06-19
POCUS COVID-19: Evaluation with ultrasound on the bedside in serious patients with COVID-19 Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidade Federal de Sao Paulo - UNIFESP Brazil 2020-04-21 2020-07-21 3.982.657, 30815320.5.0000.5505, POCUS COVID-19, RBR-43hbks, U1111-1252-1143 Phase Not Applicable Recruiting 1 3 Months 50 Luis CU Nakano, Ronald LG Flumignan 2020-06-19
Effect of convalescent plasma in patients with severe COVI-19 Coronavirus disease 19 infection convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti, Instituto do Cerebro de Brasilia Brazil 2020-04-19 2020-05-31 3,980,508, 30487220.8.1001.5267 - CAAE, RBR-4vm3yy, U1111-1251-9286 Phase 2 Clinical Recruiting 1 1 Month 20 Pedro Kurtz 2020-06-19
A First-in-Human Study in Adult Subjects Hospitalized with COVID-19 to Investigate a new product called ARGX-117 Coronavirus disease 19 infection ARGX-117 alone Complement factor C2 modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) argenx BV, Belgium Belgium 2020-04-21 2020-001546-19, ARGX-117-2001 Phase 1/Phase 2 Clinical Recruiting 1 Regulatory 2020-06-19
The role of early dialysis in the evolution of patients with COVID-19 Coronavirus disease 19 infection, Renal injury hemodialysis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Unidade de Pesquisa Clínica - Hospital das Clínicas da Faculdade de Medicina de Botucatu Fundacao de Amparo a Pesquisa do Estado Sao Paulo Brazil 2020-05-01 30614920.5.0000.5411, 4.004.277, RBR-3rdhgm, U1111-1251-0203 Phase Not Applicable Recruiting 1 118 Welder Zamoner 2020-06-19
Treatment of 2019-nCoV pneumonia with N-acetylcysteine Coronavirus disease 19 infection, SARS coronavirus infection, Viral pneumonia N-acetylcysteine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Sao Paulo Fundacao de Amparo a Pesquisa do Estado Sao Paulo Brazil 2020-04-14 3,947,348, 30420720.4.0000.0068, RBR-8969zg, U1111-1250-3564 Phase 2 Clinical Not yet recruiting 1 140 Julio Cesar Garcia de Alencar 2020-06-19
SequelaeCov: Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19) Coronavirus disease 19 infection, Lung injury, Respiratory failure, Viral pneumonia continuous positive airway pressure therapy alone, invasive mechanical ventilation alone, non-invasive ventilation alone, oxygen support therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-08-17 2021-04-30 NCT04435327, SEQUELAECOV, SequelaeCov Phase Not Applicable Recruiting 1 8 Months 300 Paola Faverio, MD 2020-06-18
VANGARD: PB-1046, a Long-acting, Sustained Release Human VIP Analog, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS) Coronavirus disease 19 infection, Respiratory distress syndrome PB-1046 alone VIP 2 receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) PhaseBio Pharmaceuticals Inc US 2020-06-26 2020-12-18 NCT04433546, PB1046-PT-CL-0007, VANGARD Phase 2 Clinical Not yet recruiting 1 5 Months 210 Clinical Trials 2020-06-19
A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh Coronavirus disease 19 infection Variable regimens including azithromycin , doxycycline hyclate , hydroxychloroquine , ivermectin Chloride channel modulator Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ministry of Health and Family Welfare, Bangladesh Xi'an Jiaotong University Bangladesh 2020-05-02 2020-06-05 10000918, NCT04434144 Phase Not Applicable Completed 1 1 Month 116 Abu Taiub Mohammed Mohiuddin Chowdhury, MBBS, MD, Mohammad Shahbaz, MBBS, MCPS 2020-06-19
Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19 Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of New Mexico US 2020-04-14 2025-04-14 20-206, NCT04435808 Phase 1/Phase 2 Clinical Recruiting 1 60 Months 350 Hadya Khawaja, MS, Walter Dehority, Walter Dehority, MD 2020-06-18
Effectiveness of herbal capsule in COVID-19 Coronavirus disease 19 infection herbal powder capsule (Punica granatum, Rheum palmatum, Glycyrrhiza glabra and Nigella sativa) alone, standard COVID-19 treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Kerman University of Medical Sciences Iran 2020-04-20 IR.KMU.REC.1399.055, IRCT20200330046899N1 Phase 3 Clinical Recruiting 1 50 Abbas Pardakhti, Dr. Hamid Aboosaeidi, Dr. Mohammad Setayesh, Mohammad Seatyesh, Mohammad Setayesh 2020-06-18
Phase II Study of the Efficacy and Safety of Intravenous Pamrevlumab, in Hospitalized Patients With Acute COVID-19 Disease Coronavirus disease 19 infection pamrevlumab alone, standard-of-care alone Connective tissue growth factor ligand inhibitor Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) FibroGen Inc 2020-06-30 2021-01-31 FGCL-3019-098, NCT04432298 Phase 2 Clinical Not yet recruiting 0 7 Months 130 Gustavo Lorente 2020-06-19
A Randomized Controlled Trial Assessing the Efficacy of Lianhua Qingwen as an Adjuvant Treatment in Patients With Mild Symptoms of COVID-19 Coronavirus disease 19 infection lianhua qingwen (oral/capsule, influenza), Yiling Pharmaceutical alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nanyang Technological University Ministry of Health, Singapore Singapore 2020-07-31 2021-02-28 IRB-2020-05-029, NCT04433013 Phase 3 Clinical Not yet recruiting 1 7 Months 300 Hui Zi Chua, Yan Zhao 2020-06-18
CRITICAL: Crizanlizumab for Treating COVID-19 Vasculopathy Coronavirus disease 19 infection, Inflammatory disease, Respiratory tract infection, Thrombosis, Vascular disease crizanlizumab alone P selectin antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Johns Hopkins University Brigham & Women's Hospital, Novartis AG, SOCAR Research SA US 2020-06-30 2020-10-31 CRITICAL, IRB00249874, NCT04435184 Phase 2 Clinical Not yet recruiting 1 4 Months 40 Charles J Lowenstein, MD, Charles Lowenstein, MD, Shannon Kelley, BS, Thorsten Leucker, MD PhD 2020-06-18
A study of 254 nm UVC ray therapy in pharynx for asymptomatic to mild cases of coronavirus disease Coronavirus disease 19 infection standard of care alone, ultraviolet C therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Akshardeep Eye Hospital India 2020-06-11 CTRI/2020/06/025766 Phase Not Applicable Not yet recruiting 1 300 Dr Jagdeep Kakadia 2020-06-19
Clinical observation of the relieving effect of Kegan Liyan oral liquid on the throat symptoms of novel coronavirus pneumonia (COVID-19) in convalescence, suspected patients and other susceptible people Coronavirus disease 19 infection Kegan Liyan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Dongguan People's Hospital China 2020-06-10 2020-12-31 ChiCTR2000033720 Phase 4 Clinical Not yet recruiting 1 6 Months 240 Chen Yiyun, Guan Ling, Hu Guanying 2020-06-19
SIDCOVID: A randomized, controlled clinical trial to determine the efficacy of siddha drugs in COVID-19 patients Coronavirus disease 19 infection Variable regimens including Amukkara choornam , Kabasura kudineer , Thalisathi choornam , adathodai manappagu Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institute of Siddha India 2020-06-15 CTRI/2020/06/025763, SIDCOVID Phase 2 Clinical Not yet recruiting 1 150 G J Christian, Meenakumari R 2020-06-19
Effectiveness of lying face down in improving the outcome of COVID-19 patients Coronavirus disease 19 infection Awake self proning strategy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AIIMS Jodhpur India 2020-06-20 CTRI/2020/06/025804 Phase Not Applicable Not yet recruiting 1 120 Dr Maya Gopalakrishnan 2020-06-19
LUSCOVIDPREG: Descriptive and Evaluation Study of the Use of Pulmonary Ultrasound in the Initial Management of Pregnant Women in the Context of COVID-19 Coronavirus disease 19 infection lung ultrasound alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille France 2020-06-15 2021-06-15 2020-30, 2020-A01303-36, LUSCOVIDPREG, NCT04432805 Phase Not Applicable Recruiting 1 12 Months 160 Jean-Olivier ARNAUD, Director, Julie BLANC, PH 2020-06-19
COPE: COPE - COVID-19 in Pregnancy and Early Childhood Coronavirus disease 19 infection biological samples, questionnaires and interviews alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sahlgrenska University Hospital Sweden 2020-06-02 2041-06-02 2020-02848 0604, COPE, NCT04433364 Phase Not Applicable Recruiting 26 252 Months 1200 Anna Sandström, MD PhD, Anna-Carin Wihlbäck, MD PhD, Anna-Karin Wikström, MD PhD, Daniel Axelsson, MD, Elisabeth Salekärr, research nurse, Emelie Ottosson, MD, Hanna Östling, MD PhD, Helena Fadl, MD PhD, Hugo Hessel, MD, Inger Sundström, MD PhD, Johanna Molin, MD, Karin Pettersson, MD PhD, Linda Hjertberg, MD, Magnus Domellöf, MD PhD, Maria Jonsson, MD PhD, Maria Svenvik, MD, Marie Blomberg, MD PhD, Marie Vikström Bohlin, MD PhD, Marie-Charlotte A Nilsson, Midwife, Matilda Friman-Mathiasson, MD, Mehreen Zaigham, MD PhD, Merit Kullinger, MD PhD, Ola Andersson, MD PhD, Ove Axelsson, MD PhD, Pihla Kuusela, MD PhD, Sandra Holmström, MD, Sebastian Brusell Gidlöf, MD PhD, Sofie Graner, MD PhD, Sophia Brismar Wendel, MD PhD, Susanne Hesselman, MD PhD, Verena Sengpiel, MD, PhD, Ylva Carlsson, MD PhD, Ylva Carlsson, MD, PhD, Åsa Leijonhufvud, MD PhD, Åsa Ponten, MD PhD 2020-06-19
COVIDOLIP: Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen Coronavirus disease 19 infection, Obesity, Sepsis, Viral pneumonia biological assays alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire Dijon France 2020-04-07 2020-05-07 COVIDOLIP, NCT04435223, NGUYEN AOIC 2020 Phase Not Applicable Completed 1 1 Month 62 2020-06-19
Effect of convalescent plasma in COVID-19 patients Coronavirus disease 19 infection Convalescent Plasma alone, Standard of Care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institute of Liver and Biliary Sciences, India India 2020-06-18 CTRI/2020/06/025803 Phase 3 Clinical Recruiting 0 400 Dr Meenu Bajpai, Dr Suresh kumar, Dr Vikas Dogra 2020-06-19
CoVPN 5001: A Study of Immune Responses to the Virus That Causes COVID-19 Coronavirus disease 19 infection sample collection alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institute of Allergy and Infectious Diseases Zambia, Peru, US, Zimbabwe, Argentina, Brazil, South Africa, Botswana, Tanzania, Mexico, Kenya, Mozambique, Malawi 2020-06-11 2021-01-31 5UM1AI068614-14, COVPN 5001, CoVPN 5001, NCT04431414 Phase Not Applicable Recruiting 62 7 Months 800 CRS Coodinator, CRS Coordinator, CRS Coorindator, CRS Leader, Clinical Trials Manager, Protocol Team Leader, Will Hahn 2020-06-18
A case report to evaluate the efficacy of recombinant tissue plasminogen activator (rt-PA) and tocilizumab in patients with COVID-19 Coronavirus disease 19 infection, Respiratory failure, Thrombosis recombinant tissue plasminogen activator (rt-PA) alone, tocilizumab alone Male, Aged Adults (65-79 yrs), Elderly Adults (80 and over) University General Hospital of Larissa Phase Not Applicable Status not specified 0 1 2020-06-18
COVIT-EHPAD: COVID-19 and Vitamin D in Nursing-home Coronavirus disease 19 infection vitamin D3 alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Angers France 2020-03-15 2020-05-15 2020/67, COVIT-EHPAD, NCT04435119 Phase Not Applicable Completed 1 2 Months 96 Cédric ANNWEILER, MD, PhD 2020-06-18
The Utility of Camostat Mesylate in Patients With COVID-19 Associated Coagulopathy (CAC) and Cardiovascular Complications Blood clotting disorder, Coronavirus disease 19 infection, Deep vein thrombosis, Heart injury, Hypoxia, Lung embolism camostat mesylate alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yale University Ono Pharmaceutical Co Ltd US 2020-08-01 2021-07-30 2000028279, NCT04435015 Phase 1/Phase 2 Clinical Not yet recruiting 1 11 Months 200 Arpita Neogi, MS, Arya Mani, MD 2020-06-18
Local application of Povidone Iodine solution in nose and oral gargle for house hold contacts of COVID19 cases Coronavirus disease 19 infection gargle alone, povidone iodine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) All India Institute of Medical Sciences, Mangalagiri India 2020-06-30 CTRI/2020/06/025928 Phase Not Applicable Recruiting 2 204 Dr Limalemla Jamir, Dr Sumita Shankar, Dr Vivekanand Kattimani 2020-06-19
Maraviroc in SARS-CoV-2 Coronavirus disease 19 infection, Viral pneumonia maraviroc alone CCR5 chemokine antagonist, CD4 agonist, HIV-1 gp120 protein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rhode Island Hospital US 2020-09-30 2020-12-31 1611471-1, NCT04435522 Phase 0 Clinical Not yet recruiting 1 3 Months 16 Anshul Parulkhar, MD, Neel S Belani, MD, Philip A Chan, MD 2020-06-19
Remote-by-Default Care in the COVID-19 Pandemic Coronavirus disease 19 infection interview alone, remote telephone conversation alone, remote video conversation alone, virtual ethnography alone University of Oxford Nuffield Trust, University of Plymouth UK 2020-06-01 2021-11-30 283196, NCT04435041 Phase Not Applicable No longer recruiting 1 18 Months 1 2020-06-18
A medical records based retrospective study of novel coronavirus pneumonia (COVID-19) patients Coronavirus disease 19 infection, Viral pneumonia Renmin Hospital of Wuhan University, West China Hospital Ministry of Science and Technology of the People´s Republic of China China 2020-06-18 2021-06-18 ChiCTR2000033782 Phase Not Applicable Not yet recruiting 1 12 Months 1400 Jirong Yue 2020-06-19
Compassionate Use of Opaganib in Patients With Coronavirus Disease 2019 (COVID-19) Coronavirus disease 19 infection opaganib alone, standard of care alone Dihydroceramide delta 4 desaturase inhibitor, Sphingosine kinase 2 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaare Zedek Medical Center Israel 2020-04-03 2020-05-15 0123-20- SZMC, NCT04435106 Phase Not Applicable Completed 1 1 Month 23 2020-06-19
Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19 Coronavirus disease 19 infection nitazoxanide alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azidus Brasil Farmoquimica SA Brazil 2020-06-30 2020-08-31 NCT04435314, NITFQM0620OR Phase 2 Clinical Not yet recruiting 1 2 Months 200 Luciana Ferrara, Marcelo Fonseca, MD, Reginaldo Raimundo Fujita 2020-06-19
A case-study to evaluate the effects of using high dose oral and/or iv glutathione in the treatment of two patients with dyspnea secondary to COVID-19 pneumonia Coronavirus disease 19 infection, Dyspnea, Pneumonia glutathione alone Hudson Valley Healing Arts Center US Phase Not Applicable Status not specified 1 2 2020-06-19
Role of Herbal Immunomodulators in mild COVID-19 confirmed cases Coronavirus disease 19 infection Bresol plus Septilin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Himalaya Drug Co India 2020-06-19 CTRI/2020/06/025801, HDC/CP/PP/037/2020 Phase 2/Phase 3 Clinical Recruiting 1 40 Dr C R Jayanthi, Dr Palaniyamma D, Dr Soorya Narayan H 2020-06-19
Study on predictors of novel coronavirus pneumonia (COVID-19) elderly patients Coronavirus disease 19 infection, Sarcopenia, Viral pneumonia Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) West China Hospital Ministry of Science and Technology of the People´s Republic of China China 2020-06-18 2020-09-01 ChiCTR2000033781 Phase Not Applicable Not yet recruiting 1 2 Months 114 Jirong Yue, Yao Ma 2020-06-19
A Phase I/II study to evaluate its tolerability and activity in COVID-19 patients with hypoxemic respiratory failure receiving either non-invasive positive pressure ventilation (NIPPV) or mechanical ventilation (MV) Coronavirus disease 19 infection, Lung inflammation, Respiratory failure Rejuveinix alone, mechanical ventilation alone, non-invasive positive pressure ventilation alone, standard of care alone Reven Pharmaceuticals Inc Phase 1/Phase 2 Clinical Planned 0 2020-06-18
Inhaled Ciclesonide for Outpatients With COVID19 Coronavirus disease 19 infection ciclesonide alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) McGill University Health Center, Research Institute of the McGill University Health Centre Canada 2020-06-25 2021-03-25 2021-6696, NCT04435795 Phase 2/Phase 3 Clinical Not yet recruiting 1 9 Months 454 Nicole Ezer, Rola Hamed 2020-06-19
STORM: Repurposing Old Drugs TO Suppress a Modern Threat: COVID-19 STORM Coronavirus disease 19 infection doxycycline hyclate alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Temple University US 2020-07-31 2021-07-31 NCT04433078, STORM, THE STORM TRIAL Phase 2 Clinical Not yet recruiting 1 12 Months 240 Arthur M Feldman, MD, PhD, Jamie L Garfield, MD 2020-06-19
A Phase I Study to Assess BAT-2020 in Hospitalized Patients Infected With SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection BAT-2020 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bio-Thera Solutions Ltd 2020-07-20 2021-01-18 BAT2020-001-CR, NCT04432766 Phase 1 Clinical Not yet recruiting 0 5 Months 174 2020-06-19
A medical records based study for analysis of Tongue Features of novel coronavirus pneumonia (COVID-19) Patients Coronavirus disease 19 infection, Viral pneumonia Dahuashan Cabin Hospital, Jiangxia District, Evidence-Based medicine center, Tianjin University of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine China 2020-06-11 2020-06-19 ChiCTR2000033780, ChiMCTR2000003393 Phase Not Applicable No longer recruiting 1 500 Junhua Zhang, Wentai Pang 2020-06-19
Association of the Neutrophil/Lymphocyte Ratio With Clinical Complications and Mortality in COVID-19 Patients Coronavirus disease 19 infection oxygen therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Regional de Alta Especialidad de Ixtapaluca Hospital General de Mexico Mexico 2020-03-28 2020-05-05 NCT04434157, NR-09-2020 Phase Not Applicable Completed 1 1 Month 221 Christian Ramos Peñafiel,, Omar Ramos-Peñafiel 2020-06-19
Age and viral load in COVID-19 patients Coronavirus disease 19 infection, SARS coronavirus infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) St Marianna University School of Medicine Japan 2020-06-18 UMIN000040816 Phase Not Applicable Not yet recruiting 1 30 Tomohiro Katsuta 2020-06-19
An observational, retrospective study to explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir Coronavirus disease 19 infection lopinavir alone The 6th People's Hospital of Hangzhou China Phase Not Applicable Status not specified 1 10 2020-06-18
Role of Ayurveda in Covid 19 management Coronavirus disease 19 infection Variable regimens including Agnikumara Rasa , Rasona kalka , Samshamani Vati , Shunthi churna , Vyaghryadi kashaya Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) National Health Mission India 2020-06-22 CTRI/2020/06/025800 Phase 2 Clinical Not yet recruiting 2 120 Adil Rais 2020-06-19
Physical Rehabilitation in ICU in ARDS Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Rehabilitation program alone, Standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Koc University Turkey 2020-03-15 2020-06-11 2020.169.IRB1.037, NCT04435080 Phase Not Applicable Completed 1 2 Months 35 Ozden Ozyemisci Taskiran, Prof 2020-06-19
IDRA-COVID19: Ivermectin versus Combined Hydroxychloroquine and Antiretroviral Drugs (ART) Among Asymptomatic COVID-19 Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mahidol University Thailand 2020-07-31 2021-11-30 323/2563 (IRB3), IDRA-COVID19, NCT04435587 Phase 4 Clinical Not yet recruiting 1 16 Months 80 Rujipas Sirijatuphat, MD, Yupin Suputtamongkol, Yupin Suputtamongkol, MD 2020-06-19
A retrospective study on arbidol monotherapy was superior to lopinavir/ritonavir in treating COVID-19 Coronavirus disease 19 infection arbidol alone, lopinavir + ritonavir alone HIV protease inhibitor The Third People’s Hospital of Changzhou Phase Not Applicable Status not specified 0 50 2020-06-18
RESCUE1-19: Best Supportive Care With or Without Low Dose Whole Lung Radiation Therapy for the Treatment of COVID-19 Coronavirus disease 19 infection Low Dose Radiation Therapy (LDRT) alone, best supportive care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Emory University US 2020-06-12 2022-05-30 NCI-2020-04061, NCT04433949, P30CA138292, RAD5049-20, RESCUE1-19, STUDY00000781 Phase 3 Clinical Recruiting 1 23 Months 52 Allyson Anderson, Autumn Lunceford, Clayton B Hess, MD, MPH, Clayton B. Hess, MD,MPH, Mohammad K Khan, MD, PhD, Mohammad K. Khan, MD, PhD 2020-06-18
Ketotifen: as a Cardioprotective Agent in Breast Cancer Patients Receiving Anthracycline-containing Chemotherapy Breast tumor, Cardiotoxicity drug-induced, Coronavirus disease 19 infection anthracycline-containing chemotherapy alone, ketotifen alone Histamine H1 receptor antagonist Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Horus University (EG) Egypt 2019-01-14 2019-08-13 1890-1-2019, NCT04435028 Phase Not Applicable Completed 1 7 Months 111 Hosny ahmed elewa 2020-06-18
The effect of vitamin C and E in the treatment and clinical course of patients with SARS-COV2 (COVID-19) Coronavirus disease 19 infection hydroxychloroquine diet alone, Variable regimens including hydroxychloroquine sulfate , lopinavir + ritonavir , vitamin C , vitamin E HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Isfahan University of medical Sciences Iran 2020-04-20 IR.MUI.MED.REC.1399.047, IRCT20180425039414N3 Phase 2/Phase 3 Clinical No longer recruiting 1 80 Atousa Hakamifard, Shghayegh Haghjoo Javanmard 2020-06-19
A multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19 Coronavirus disease 19 infection chloroquine alone, hydroxychloroquine alone, macrolide alone, chloroquine plus hydroxychloroquine Harvard Medical School Phase Not Applicable Status not specified 0 96032 2020-06-18
Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets in Treating Pediatric novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Standard treatment alone, bromhexine hydrochloride alone Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Children's Hospital of Zhejiang University School of medicine Zhejiang Wanbang Pharmaceutical Co Ltd China 2020-02-12 2020-12-31 ChiCTR2000033774 Phase 4 Clinical Not yet recruiting 1 10 Months 30 Qingqing Wang, Zhimin Chen 2020-06-19
Treatment With Investigational Convalescent Plasma and Measure Antibody Levels in Patients Hospitalized With COVID-19 Coronavirus disease 19 infection Anti-SARS-CoV-2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of New Mexico US 2020-04-28 2025-04-28 20-227, NCT04434131 Phase 2 Clinical Recruiting 1 60 Months 30 Greg Mertz, MD, Michelle Harkins, MD 2020-06-19
A retrospective, single center study on treatment response of tocilizumab in COVID-19 Coronavirus disease 19 infection tocilizumab alone Huazhong University of Science and Technology Phase Not Applicable Status not specified 0 15 2020-06-18
Clinical study on the effect of Keganliyan oral liquid on the relief of pharyngeal symptoms of novel coronavirus pneumonia (COVID-19) in convalescence, suspected patients and other susceptible populations Coronavirus disease 19 infection Keganliyan liquid alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Maoming Affiliated Hospital of Southern Medical University China 2020-06-15 2020-12-31 ChiCTR2000033745 Phase 4 Clinical Not yet recruiting 1 6 Months 240 Guanying Hu, Yaocai Li 2020-06-19
A Real-life, case-series study to report preliminary data obtained with anti-complement C5 therapy with eculizumab in COVID-19 patients admitted to intensive care unit (ICU) of ASL Napoli 2 Nord Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia eculizumab alone, enoxaparin sodium alone, non-invasive ventilation alone, vitamine C alone, Variable regimens including ceftriaxone , hydroxychloroquine , lopinavir + ritonavir Complement C5 factor inhibitor, HIV protease inhibitor, Low molecular weight heparin Santa Maria delle Grazie, Pozzuoli Phase 4 Clinical Status not specified 0 4 2020-06-19
A study for long-term prognosis in hospitalized novel coronavirus pneumonia (COVID-19) patients Coronavirus disease 19 infection China-Japan Friendship Hospital, Wuhan Jinyintan Hospital China Academy of Chinese Medical Sciences China 2020-05-01 2021-05-01 ChiCTR2000033723 Phase Not Applicable Not yet recruiting 1 12 Months 2500 LIU YING, Zhang DY, Huang CL, Cao B 2020-06-19
Seroconversion Among Staff at a Large Acute Care Hospital in Denmark During the COVID-19 Pandemic Coronavirus disease 19 infection biological sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nordsjaellands Hospital Nykøbing Falster County Hospital, University of Oxford Denmark 2020-03-27 2025-08-01 JOURNAL-NR.: H-20022312, NCT04431310 Phase Not Applicable Recruiting 2 64 Months 300 Fischer, Gry St-Martin, md, Thea K Fischer, Thea K Fischer, professor 2020-06-19
CARAVAN: Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Remdesivir (GS-5734) in Participants From Birth to < 18 Years of Age With Coronavirus Disease 2019 (COVID-19) Coronavirus disease 19 infection remdesivir alone COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Gilead Sciences Inc US, Europe 2020-06-30 2020-12-31 2020-001803-17, CARAVAN, GS-US-540-5823, NCT04431453 Phase 2/Phase 3 Clinical Not yet recruiting 1 6 Months 52 Gilead Clinical Study Information Center, Gilead Study Director 2020-06-19
An observational study to evaluate the pharmacokinetics of favipiravir in patients with severe COVID-19 who were admitted to the intensive care unit and placed on mechanical ventilation Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Kobe City Medical Center General Hospital, Kobe Gakuin University Phase Not Applicable Status not specified 0 7 2020-06-18
Assessment of the Effectiveness of Vibroacoustic Therapy for Respiratory Failure Caused by COVID 19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure, Viral pneumonia VibroLUNG alone, vibroacoustic therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Astana Medical University Kazakhstan 2020-03-22 2021-02-01 ASTANAMU, NCT04435353 Phase Not Applicable Recruiting 2 10 Months 200 Irina Mukatova, MD, Irina Mukatova, PhD, Ivan Vahrushev, Dr, Mukatova Irina 2020-06-19
Impact of Cancellation of Non-urgent Surgical Cases on Patients During the COVID-19 Pandemic Coronavirus disease 19 infection Mansoura University Egypt 2020-07-01 2020-12-01 NCT04433312, SURG RES COL 2 Phase Not Applicable Not yet recruiting 1 5 Months 10000 Ahmed M Elsheikh, MD,MBA,CMQOE, Hosam Hamed, MD, MSc, PhD, Mostafa M Shalaby, MD, MSc, PhD, Mostafa Shalaby, MD, MSc, PhD 2020-06-18
Study to Assess VPM-1002 in Reducing Hospital Admissions and/or Severe Respiratory Infectious Diseases in Elderly in COVID-19 Pandemic Coronavirus disease 19 infection, Respiratory tract infection VPM-1002 alone Listeriolysin stimulator Healthy volunteers accepted, Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max-Planck Gesellschaft zur Förderung Der Wissenschaften eV, Vakzine Projekt Management GmbH FGK Clinical Research GmbH Germany 2020-06-30 2021-05-31 2020-001675-33, NCT04435379, VPM1002-DE-3.07COV Phase 3 Clinical Recruiting 4 11 Months 2038 Clinical Trial Information, Leander Grode, Dr. rer. nat. 2020-06-19
PEDONCOVID: COVID-19 in Pediatric Oncology and Hematology Centers in France Cancer, Coronavirus disease 19 infection Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) Caen University Hospital France 2020-04-27 2023-04-27 20-065, NCT04433871, PEDONCOVID Phase Not Applicable Recruiting 1 36 Months 300 Jérémie M Rouger-Gaudichon, MD, PhD, Jérémie Rouger-Gaudichon, MD, PhD 2020-06-19
PrimaryCovCare: Ambulatory healthcare models and processes during the ongoing SARS-CoV-2 pandemic (COVID-19) Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Heidelberg Germany 2020-06-17 DRKS00022224, PrimaryCovCare, S-418/2020 Phase Not Applicable Recruiting 1 1000 Amanda Breckner, Catharina Roth, Michel Wensing, Sandra Stengel 2020-06-19
To evaluate the efficacy of diammonium glycyrrhizinate in combination with vitamin C in patient with COVID-19 Coronavirus disease 19 infection diammonium glycyrrhizinate plus vitamin C Female National Institute of Allergy and Infectious Diseases, National Institute of General Medical Sciences, National Institutes of Health, US Department of Health and Human Services Phase Not Applicable Status not specified 0 1 2020-06-18
A clinical trial of VLP vaccine (COVID-19), Saiba for the potential prevention of SARS-CoV-2 infection (COVID-19) Coronavirus disease 19 infection VLP vaccine (COVID-19), Saiba alone COVID19 Spike glycoprotein modulator Saiba GmbH 2020-12-31 Phase Not Applicable Planned 0 2020-06-18
IFORS: A Study to Compare the Efficacy and Safety of Different Doses of Ivermectin for COVID-19 Coronavirus disease 19 infection, Respiratory disease, Respiratory tract infection ivermectin alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundação Universidade Federal De São Carlos Brazil 2020-07-01 2021-07-01 IFORS, IFORS, NCT04431466 Phase 2 Clinical Not yet recruiting 1 12 Months 64 Henrique Pott Junior, Henrique Pott Junior, MD PhD 2020-06-19
Cardiovascular Implications of COVID-19 Coronavirus disease 19 infection, Heart injury [1-13C] pyruvate alone, multiparametric cardiac magnetic resonance imaging (CMR) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Texas Southwestern Medical Center 2020-06-30 2020-10-31 NCT04435457, STU-2020-0359 Phase Not Applicable Not yet recruiting 0 4 Months 70 Carolyn Kelly, RN, MPH, CCRC, Justin L Grodin, MD, MPH 2020-06-19
To observe the effect of Siddha formulation Kabasura kudineer in COVID 19 patients Coronavirus disease 19 infection Kabasura kudineer alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Government Theni Medical College and Hospital, Ministry of Ayush India 2020-06-24 CTRI/2020/06/025874 Phase 2 Clinical Not yet recruiting 1 60 Dr C Anbarasi, Dr P Sankararaj 2020-06-19
A phase II/III study of COVAX-19 in prevention of COVID-19 Coronavirus disease 19 infection Covax-19 alone Coronavirus spike glycoprotein inhibitor Vaxine Pty Ltd 2020-12-31 Phase 2/Phase 3 Clinical Planned 0 2020-06-19
Study of AYUSH KWATH in quarantine persons Coronavirus disease 19 infection Ayush Kwath alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Dr. Sarvepalli Radhakrishnan Rajasthan Ayurveda University India 2020-06-17 CTRI/2020/06/025779 Phase Not Applicable Not yet recruiting 1 50 Prof Dr Abhimanyu Kumar 2020-06-19
A case series, retrospective study on 18F-FDG PET/CT findings of COVID-19 infection Coronavirus disease 19 infection, Respiratory disease 18F-FDG alone, positron emission tomography/computed tomography alone Chang Gung Memorial Hospital, Huazhong University of Science and Technology, Hubei Province Pharmaceutical Industry Research Institute China Phase Not Applicable Status not specified 1 4 2020-06-18
A retrospective, multicenter, cohort study to describe the association between use of hydroxychloroquine, with or without azithromycin, and clinical outcomes among hospital inpatients diagnosed with coronavirus disease 2019 (COVID-19) Coronavirus disease 19 infection azithromycin alone, hydroxychloroquine alone, azithromycin plus hydroxychloroquine UAlbany School of Public Health US Phase Not Applicable Status not specified 1 1438 2020-06-18
A prophylactic interventional study to determine the possible protective effect of Siddha Polyherbal formulation Kabasura Kudineer / Nilavembu kudineer against the COVID-19 on intermittent, month-long consumption by Highrisk population and frontline workers in Tamil Nadu, India Coronavirus disease 19 infection Standard of Care alone, Kabasura Kudineer plus Nilavembu kudineer National Institute of Siddha India 2020-06-15 CTRI/2020/06/025769 Phase 2/Phase 3 Clinical Not yet recruiting 1 500 Dr G J Christian, Dr R Meenakumari 2020-06-19
TOCCIP: COVID-19 Critically Ill Patients Evolution After Medical Transport by Train From Paris Intensive Care Units to West of France Intensive Care Units Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rennes University Hospital France 2020-06-30 2020-09-30 35RC20-3091-TOCCIP, NCT04433325, TOCCIP Phase Not Applicable Not yet recruiting 2 3 Months 150 Anne Ganivet, Arnaud THILLES, Benoît Painvin, Nicolas Mevel, Stéphane ERHMANN 2020-06-19
Impact of COVID-19 on Laboratory Professionals-Early Evidences from a Survey at a Clinical Chemistry Laboratory in a Developing Country Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Aga khan University Pakistan 2020-06-04 2020-06-14 ChiCTR2000033899 Phase Not Applicable No longer recruiting 1 64 Sibtain Ahmed 2020-06-19
An open-label, Randomized Controlled Clinical trial to Evaluate the Safety and Efficacy of selected Siddha formulations in patients diagnosed with COVID-19 Coronavirus disease 19 infection siddha formulation alone, Variable regimens including Kabasura kudineer , Nellikai Ilagam , amukkara churnam Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Chengalpattu Medical College, National Institute of Siddha India 2020-06-20 CTRI/2020/06/025768 Phase 2 Clinical Not yet recruiting 1 200 Dr G J CHRISTIAN, Dr MEENAKUMARI R 2020-06-19
Natural Language Processing (NLP) Analysis of Free Text Notes to Investigate Coronavirus (COVID-19) Coronavirus disease 19 infection, Renal injury, Thromboembolism electronic health record (EHR) alone, natural language processing techniques alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cambridge University Hospitals NHS Foundation Trust University of Cambridge UK 2020-07-31 2021-07-31 A095625, NCT04432961 Phase Not Applicable Not yet recruiting 1 12 Months 200 Dr Sapna Trivedi 2020-06-19
An interim Doherty Report on SARS-CoV-2 antibodies based on Wondfo test (serology-based COVID-19 POC test) Coronavirus disease 19 infection Wondfo test (serology-based COVID-19 POC test) alone Cellmid Ltd Australia Phase Not Applicable Status not specified 1 137 2020-06-18
The Use of Lung Ultrasonography in COVID-19 Patients Coronavirus disease 19 infection, Respiratory failure mechanical ventilator settings and position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gaziosmanpasa Taksim Research and Education Hospital Turkey 2020-05-26 2020-06-26 GAZIOSMANPASA, NCT04432051 Phase Not Applicable Recruiting 1 1 Month 100 SİBEL BEKTAŞ 2020-06-19
Community Health Workers Against COVID19 Anxiety disorder, Coronavirus disease 19 infection community health worker support alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitaet Gent Belgium 2020-05-21 2020-10-30 BC-07744., NCT04426305 Phase Not Applicable Recruiting 1 5 Months 140 2020-06-19
A Study of Favipiravir in Patients with Mild to Moderate Coronavirus Disease (COVID-19) Coronavirus disease 19 infection favipiravir alone, supportive care  alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Cipla Ltd India 2020-06-17 CP/04/20, Version No. 1.0, CTRI/2020/06/025799 Phase 3 Clinical Not yet recruiting 8 156 Dr Ameet Dravid, Dr Anand Kumar, Dr Atul Patel, Dr Jaideep Gogtay, Dr Meenakshi Bhattacharya, Dr Raja Dhar, Dr Rohidas Borse, Dr Sandesh Sawant, Dr Shreepad Bhat, Dr Vasant Nagvekar, Mr Abhijit Vaidya 2020-06-19
ICON STUDY: A Clinical trial to establish the appropriate line of management of non-muscle invasive bladder cancers who have had their intravesical BCG therapy interrupted Bladder cancer, Coronavirus disease 19 infection BCG alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences, All India Institute of Medical Sciences Bhubaneswar, Christian Medical College, Vellore, India, Jawaharlal Institute of Postgraduate Medical Education Research, Postgraduate Institute of Medical Education and Research, king george's medical university India 2020-06-18 CTRI/2020/06/025798, ICON STUDY Phase 4 Clinical Not yet recruiting 10 70 Amlesh Seth, Aneesh Srivastava, Dr Tushar Aditya Narain, Gautam Ram Choudhary, Manikandan Ramanidhatharan, Prasant Nayak, Sameer Trivedi, Santosh Kumar, Satya Narayan Sankhwar, Shrawan Kumar Singh, Tushar Aditya Narain 2020-06-19
Quality of Life During COVID-19 Lockdown Coronavirus disease 19 infection, Pain Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Cancer Institute, Jhajjar, AIIMS India 2020-06-13 CTRI/2020/06/025797 Phase Not Applicable Not yet recruiting 1 Anuja Pandit 2020-06-19
Effect of aragwadhadi kwath (kadha in Hindi) in treatment of mild coronavirus disease Coronavirus disease 19 infection aragwadhadi kwath alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Sanjivani Aryuvedic Centre India 2020-06-15 CTRI/2020/06/025796 Phase Not Applicable Not yet recruiting 1 90 Dr Sunil Panjwani, Vaidhya Tushar Trivedi 2020-06-19
Effects of Lockdown during Corona Pandemic on Children with Neurodevelopmental Disorders-A Questionnaire Based Survey Attention deficit hyperactivity disorder, Autism, Coronavirus disease 19 infection question based survey alone Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs) Army Hospital Research and Referral India 2020-06-15 CTRI/2020/06/025795 Phase Not Applicable Not yet recruiting 1 150 J N Goswami, Shuvendu Roy 2020-06-19
Effect of anakinra in treatment of COVID-19 Coronavirus disease 19 infection anakinra, Persisgen alone, recommended COVID-19 treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Persisgen Par Co Iran 2020-06-21 IR.SBMU.PHARMACY.REC.1399.051, IRCT20120703010178N20 Phase 3 Clinical Not yet recruiting 1 30 Amir Behnam Kharazmi, Amir Hossein Karagah, Mohammad Sistanizad, Omid Moradi 2020-06-19
A Study to Assess the Effect of Beckman Coulter SARS-CoV-2 Antibody Test in Patients with COVID-19 Coronavirus disease 19 infection Beckman Coulter SARS-CoV-2 antibody test alone Henry Ford Health System Phase Not Applicable Status not specified 0 2020-06-18
PRO-SERO-COV: Serological Response to SARS-Cov-2 Virus in Personnel of the Institut Bergonie in the Context of the COVID-19 Pandemic Coronavirus disease 19 infection blood sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut Bergonie France 2020-06-30 2021-12-31 2020-A01355-34, IB 2020-01, NCT04426006, PRO-SERO-COV Phase Not Applicable Not yet recruiting 1 18 Months 1000 Brice RICHEZ, MD, Simone MATHOULIN-PELISSIER, MD, PhD 2020-06-18
TA/SARS-Cov2: Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients? Coronavirus disease 19 infection biopsies of subcutaneous adipose tissue alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Nice France 2020-07-01 2021-07-09 20-PP-15, NCT04427878, TA/SARS-Cov2 Phase Not Applicable Not yet recruiting 1 12 Months 5 Berengère Chignon-Sicard, PH, Vanina OLIVERI, PM 2020-06-18
CIO: Impact of COVID-19 Lockdown on Obesity and Eating Behaviors Acute stress disorder, Anxiety disorder, Binge eating disorder, Coronavirus disease 19 infection, Depression, Obesity Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2020-06-30 2020-09-30 2020-A01616-33, 69HCL20-0516, CIO, NCT04431284 Phase Not Applicable Not yet recruiting 1 3 Months 46 Emmanuel DISSE, MD, Martine LAVILLE, MD 2020-06-19
ABACCuS: Antibody-Level Based Analysis of COVID Convalescent Serum Coronavirus disease 19 infection COVID-19 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) William Beaumont Hospitals US 2020-06-30 2021-08-31 2020-198, ABACCuS, NCT04432272 Phase 2 Clinical Not yet recruiting 1 14 Months 500 Matthew Sims, MD, Matthew Sims, MD PhD, Maureen Cooney, RN, BSN 2020-06-19
Favipiravir effectiveness in patients undergoing COVID19 Acute respiratory distress syndrome (ARDS) Coronavirus disease 19 infection, Respiratory distress syndrome favipiravir alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Masih Daneshvari Hospital Iran 2020-03-20 2020-05-21 IR.SBMU.NRITLD.REC.1399.041, IRCT20150107020592N26 Phase 3 Clinical Completed 1 2 Months 20 DR Reza Masoodi, Seyed Mohammad Reza Hashemian, Seyyed Mohammadreza Hashemian 2020-06-19
Prone Positioning on Admission for Hospitalized COVID-19 Pneumonia Protocol Coronavirus disease 19 infection, Viral pneumonia Prone Positioning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Poudre Valley Health System US 2020-06-30 2020-12-31 20-6034, NCT04424797 Phase Not Applicable Recruiting 3 6 Months 100 Adam Jaskowiak, Lucie Uncapher, Lucie Uncapher, MD, Research Manager, Sara Twombly, MACI CCRC 2020-06-18
Treatment of COVID-19 whit vitamin A Coronavirus disease 19 infection vitamin A, Ovigel Company alone Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ghoum University of Medical Sciences Iran 2020-05-04 2020-06-13 IR.MUQ.REC.1399.045, IRCT20200314046774N1 Phase 3 Clinical Completed 1 1 Month 94 Majid Farhadifard 2020-06-19
Combined effects of Extracts on Covid-19 Coronavirus disease 19 infection herbal teas alone Shiraz University of Medical Sciences Iran 2020-06-21 IR.SUMS.REC.1399.179, IRCT20200508047345N1 Phase Not Applicable Not yet recruiting 1 100 Mohammad Jamal Saharkhiz 2020-06-19
I-GLOBAL: Validation of an Immunochromatographic Assay for IgG/IgM Antibodies to 2019- nCoV Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia IgG/IgM rapid test cassette alone, immunochromatographic assay alone, polymerase chain reaction alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) European Institute of Oncology ASST Papa Giovanni XXIII, Azienda Ospedale Niguarda Cà Granda, Company Socio - Cremona Territorial Health, Fondazione IRCCS Istituto Neurologico Carlo Besta Italy 2020-04-15 2020-12-31 I-GLOBAL, I-GLOBAL, NCT04434417 Phase Not Applicable Recruiting 5 8 Months 1000 Alberto Zambelli, MD, Antonio Marra, MD, Atanasio Nonis, PhD, Daniele Generali, MD, Francesco Di Meco, MD, Giuseppe Curigliano, MD, Giuseppe Curigliano, MD, PhD, Salvatore Siena, MD 2020-06-18
Treatment of Covid-19 patients with convalescent plasma Coronavirus disease 19 infection convalescent covid-19 plasma therapy alone Iranian blood transfusion organization Iran 2020-05-25 IR.TMI.REC.1399.003, IRCT20200525047562N1 Phase 3 Clinical Recruiting 2 100 Hamid Reza Kouhpayeh, Mandana Pouladzadeh, Peyman Eshghi, Saeed Mohammadi, Shamsi Okati 2020-06-19
A Gamified Network for Surgical Education During COVID-19: A Randomized Controlled Trial Coronavirus disease 19 infection Peer-learning alone, Peer-learning with expert feedback alone, Self-learning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universite De Montreal 2020-06-30 2020-06-30 CERSES 20-068-D, NCT04425499 Phase Not Applicable Not yet recruiting 0 60 Érica Patocskai, Assistant professor 2020-06-19
Covid-No-Thank you: Data evaluation of an online symptom and risk detection application for COVID-19 research Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Orthopädische Universitätsklinik Friedrichsheim gGmbH University Hospital Magdeburg Germany 2020-04-29 65/20, Covid-No-Thank you, DRKS00022185, U1111-1252-6946 Phase Not Applicable Recruiting 1 10000 Dietmar Urbach, Gutingi-Medical GmbH 2020-06-19
The effect of pentaglobin in the treatment of critically ill patients with COVID-19 Coronavirus disease 19 infection, Respiratory failure pentaglobin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-03-20 IR.SBMU.NRITLD.REC.1399.014, IRCT20150107020592N27 Phase 3 Clinical Recruiting 1 60 Dr Seyyed Mohamadreza Hashemian, Seyyed Mohammadreza Hashemian 2020-06-19
Proper Nutrition And Its Relation To Oral Diseases In Covid -19 Era Coronavirus disease 19 infection, Mouth disease Proper diet alone, Vitamins alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) October University for Modern Sciences and Arts Egypt 2020-06-08 2020-06-28 12345678, NCT04434014 Phase Not Applicable Recruiting 1 300 Lecturer Mona abdelmoteleb, Samah Kamel, A .Prof, Samah Mohamed Kamel, A.Prof, Samah Mohamed Kamel, associate professr, lecturer Mona Abdelmoteleb 2020-06-18
ASTANA: Oncological Surgery in Times of COVID-19: Effectiveness of Preoperative Screening for Sars-Cov-2 Cancer, Coronavirus disease 19 infection SARS-CoV-2 PT-PCR test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Brasileiro de Controle do Cancer Brazil 2020-05-11 2020-12-31 33467320.0.0000.0072, ASTANA, NCT04434261 Phase Not Applicable Recruiting 1 7 Months 1500 Alayne Yamada, PhD, Andre Lopes, MD 2020-06-18
Evaluation of the effectiveness of traditional medicine combination based on the Ferula assa-foetida gum - Tragacanth in Participants with Moderate to Severe Coronavirus Disease (COVID-19) Coronavirus disease 19 infection Ferula assa-foetida gum plus tragacanth Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mashhad University of Medical Sciences Iran 2020-06-19 IR.MUMS.REC.1399.285, IRCT20200607047675N1 Phase 3 Clinical Recruiting 1 100 Dr. Amin Bojdy, Dr. HamidReza Bahrami Taghanaki, Dr. Majid Jafarinejad, Nayereh Esmaeilzadeh, ِDr. Mohsen Tafaghdi 2020-06-19
Treatment of Severe and Critical COVID-19 Pneumonia With Convalescent Plasma Coronavirus disease 19 infection, Viral pneumonia anti sars-cov 2 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) American British Cowdray Medical Center Mexico 2020-06-19 2020-09-30 ABC-20-14, NCT04432103 Phase 2 Clinical Recruiting 1 3 Months 36 Benjamín Valente, MD MSc DTMH, Francisco Moreno, MD, Irma Hoyo, MD PHD, Paulina Trápaga, MBE 2020-06-19
An interventional study to evaluate the safety and immune response of a vaccine against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2, the virus that causes COVID-19 infection) when given to healthy adult participants Coronavirus disease 19 infection SARS-CoV-2 Sclamp alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University of Queensland Coalition for Epidemic Preparedness Innovations Australia 2020-07-14 ACTRN12620000674932p, UQ-1-SARS-CoV-2-Sclamp Phase 1 Clinical Not yet recruiting 1 120 Dr Paul Griffin 2020-06-19
CoPE-HCP: COVID19 and Physical and Emotional Wellbeing of HCP Anxiety disorder, Coronavirus disease 19 infection, Depression, Psychotic disorder Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Queen Mary University of London UK 2020-06-30 2021-06-30 284686, CoPE-HCP, NCT04433260 Phase Not Applicable Not yet recruiting 1 12 Months 1050 Ajay Gupta, MD, PhD, Ajay Gupta, MD,PhD 2020-06-18
ACCOLADE: Amnion cells for COVID-19 related respiratory failure Coronavirus disease 19 infection, Respiratory failure amniotic epithelial cells (hAECs) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Monash Health Australia 2020-06-29 ACCOLADE, ACTRN12620000676910p Phase 1/Phase 2 Clinical Not yet recruiting 1 40 A/Prof Rebecca Lim, Prof Yahya Shehabi 2020-06-19
Efficacy of Pentoxifylline as Add-on Therapy in COVID-19 Patients Coronavirus disease 19 infection pentoxifylline SR alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University of Sadat City Egypt 2020-06-13 2020-08-30 NCT04433988, RC-6-2020 Phase 1/Phase 2 Clinical Not yet recruiting 1 2 Months 200 Mahmoud S Abdallah, PhD 2020-06-18
Perceptions, Representations and Experiences of Septic Isolation of Hospitalized Patients for COVID-19 Infection Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Intercommunal Creteil France 2020-07-01 2020-07-15 ISOCOV, NCT04432922 Phase Not Applicable Not yet recruiting 1 15 Alice RAFFETIN, MD 2020-06-19
In-utero Vascular Accidents in Neonates From COVID-19 Infected Mothers Coronavirus disease 19 infection, Fetal growth restriction, Limb development disorder, Premature labor, Spontaneous abortion SARS-CoV-2 antibody testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Colorado, Denver, US US 2020-07-31 2022-07-31 20-1399, NCT04431869 Phase Not Applicable Not yet recruiting 1 24 Months 200 Jose L Diaz-Miron, MD 2020-06-18
Validation of a Rapid Quantitative Test for Loss of Smell in COVID-19 Subjects Coronavirus disease 19 infection, Dysomia olfactory device alone, rapid quantitative olfactory smell test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yale University US 2020-06-15 2020-10-01 2000028259, NCT04431908 Phase Not Applicable Not yet recruiting 1 3 Months 250 R Peter Manes, MD, FACS 2020-06-18
An Open-Label Randomized Controlled, Proof-of-Concept (PoC) Study to Evaluate the Safety and Efficacy of selected Siddha formulations in patients diagnosed with COVID-19 Coronavirus disease 19 infection Variable regimens including Amukkara choornam , KS kudineer , Nellikkai ilagam Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institute of Siddha India 2020-06-15 CTRI/2020/06/025762 Phase 3 Clinical Not yet recruiting 1 200 Dr G J Christian, Dr R Meenakumari 2020-06-18
Population based cross-sectional study for COVID 19 prophylaxis with Polyherbal Siddha formulation Kabasura Kudineer / Nilavembu kudineer in containment zones and non containment zones during 2020 pandemic in Tamil Nadu, South India Coronavirus disease 19 infection Kabasura Kudineer / Nilavembu kudineer alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) National Institute of Siddha India 2020-06-15 CTRI/2020/06/025761 Phase Not Applicable Not yet recruiting 1 10000 Dr G J Christian, Dr R Meenakumari 2020-06-18
A clinical trial to study the effect of drug named Sofosbuvir in hospitalized patients with COVID 19 Coronavirus disease 19 infection hydroxychloroquine plus sofosbuvir Hepatitis C virus NS5B polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Vijaya Medical and Educational Trust India 2020-06-17 CTRI/2020/06/025760 Phase 3 Clinical Not yet recruiting 1 50 Babu N 2020-06-19
PoWerS: COVID-19 Psychological Wellbeing for Healthcare Students Coronavirus disease 19 infection Psychological wellbeing for healthcare workers alone Healthy volunteers accepted University of Nottingham 2020-06-13 2020-12-30 NCT04429828, POWERS_JUNE2020, PoWerS Phase Not Applicable Not yet recruiting 0 6 Months 45 Holly Blake, PhD 2020-06-19
Hydroxychloroquine May Reduce Risk of COVID-19 Infection in Rheumatoid Arthritis Patients Coronavirus disease 19 infection, Rheumatoid arthritis glucocorticoid therapy alone, Variable regimens including hydroxychloroquine , leflunomide , methotrexate , sulfasalazine Dihydroorotate dehydrogenase inhibitor, Protein tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University of Sadat City Egypt 2020-03-20 2020-06-20 IRB: RC-5-2020, NCT04434118 Phase Not Applicable Recruiting 1 3 Months 600 2020-06-18
CAHMP-ED: COVID-19 and the Healthy Minds Program for Educators Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy Minds Program Foundations Training alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Wisconsin-Madison Center for Healthy Minds, Chan Zuckerberg Initiative, Healthy Minds Innovations 2020-06-10 2022-06-30 2020-0533, A171600, CAHMP-ED, EDUC/COUNSELING PSYCH, NCT04426318, PROTOCOL APPROVAL 6/4/2020 Phase Not Applicable Not yet recruiting 0 24 Months 400 Corrina Frye, Simon B Goldberg, PhD 2020-06-17
A clinical study of nelfinavir in combination with amodiaquine for the treatment of COVID-19 Coronavirus disease 19 infection amodiaquine plus nelfinavir HIV protease inhibitor, HIV-1 protease inhibitor Norwegian University of Science and Technology (NTNU) Phase Not Applicable Planned 0 2020-06-17
Effect of Auriculotherapy in treatment of COVID-19 Coronavirus disease 19 infection orchicotherapy alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Shahid Sadoughi University of Medical Sciences and Health Services Iran 2020-04-28 IR.SSU..REC.1399.030, IRCT20180608040007N2 Phase Not Applicable Recruiting 1 70 Dr. Masoud Mirzaei, Maryam Mohammadi, Mohammad Bagher Khani 2020-06-18
Dornase Alpha for the Treatment of COVID-19 Coronavirus disease 19 infection dornase alfa alone Deoxyribonuclease I stimulator, Deoxyribonuclease stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Acibadem University The Scientific and Technological Research Council of Turkey Turkey 2020-05-25 2020-09-25 8820, NCT04432987 Phase 2 Clinical Recruiting 1 4 Months 60 Ercument Ovalı, MD, Ercument Ovalı, Prof. 2020-06-18
Effect of Atazanavir/Ritonavirin treatment of COViD-19 Coronavirus disease 19 infection atazanavir sulfate + ritonavir (HIV infection), Mylan Laboratories alone HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Alborz University of Medical Science Iran 2020-06-14 IR.ABZUMS.REC.1399.065, IRCT20200504047298N1 Phase 3 Clinical Recruiting 1 100 Zeinab Siami 2020-06-18
ELIKYA COVID: Impact of SARS-CoV-2 Infection During Pregnancy on Newborns and Young Children Coronavirus disease 19 infection, Pregnancy disorder nasal swab test alone, serology test alone Centre Hospitalier Universitaire Saint Pierre Institute for Medical Immunology (IMI), Laboratoire Hospitalier Universitaire de Bruxelles Belgium 2020-06-25 2024-06-30 ELIKYA COVID, ELIKYA COVID, NCT04432779 Phase Not Applicable Not yet recruiting 1 48 Months 3000 Julie Belhomme, MD, Tessa Goetghebuer, MD, Tessa Goetghebuer, MD PhD, Tessa Goetghebuer, MD, PhD 2020-06-19
HIBISCUS: A phase II/III pivotal, randomized, placebo-controlled Traumakine study in severely ill COVID-19 patients Adult respiratory distress syndrome, Coronavirus disease 19 infection, Influenza virus infection FP-1201 alone CD73 agonist, Interferon beta ligand Faron Pharmaceuticals Ltd US HIBISCUS Phase 2/Phase 3 Clinical Planned 1 350 Prof. Daniel Talmor 2020-06-17
CovImmune 2: Study of the Incidence of SARS-CoV-2 Infection Coronavirus disease 19 infection blood sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Nice France 2020-07-15 2025-12-31 20-PP-14, CovImmune 2, NCT04429594 Phase Not Applicable Not yet recruiting 1 65 Months 1000 Barbara SEITZ, MCUPH, Barbara SEITZ- POLSKI, Christian PRADIER, barbara SEITZ POLSKI, sonia BOYER SUAVET 2020-06-18
COVID-19 Versus H1N1: Radiological Challenge During Next Influenza Season Rising Coronavirus disease 19 infection, Influenza virus infection, Viral pneumonia GE LightSpeed Plus 4 slice CT scanner (USA) alone, Philips Brilliant-16 (USA) alone, Siemens SOMATOM Sensation 64 (Germany) alone, Siemens SOMATOM Emotion 16 alone, Toshiba Aquilion 64 alone, Toshiba Aquilion CXL/CX 128 (USA) alone, high-resolution computed tomography alone Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Alexandria Egypt 2020-05-22 2020-06-14 IRB (00012098), SN (0304669), NCT04433039 Phase Not Applicable Completed 1 130 Ahmed Samir, MD 2020-06-18
SURG-SAT-19: COVID-19 - Implications on Surgeons' Burnout and Career Satisfaction Acute stress disorder, Coronavirus disease 19 infection cloud-based software (SurveyMonkey) alone, online survey alone Healthy volunteers accepted Mansoura University Egypt 2020-06-15 2020-08-31 NCT04433286, SURG RES COL 1, SURG-SAT-19 Phase Not Applicable Not yet recruiting 1 2 Months 1000 Ahmed M Elsheikh, MD,MBA,CMQOE, Hosam Hamed, MD, MSc, PhD, Mostafa Shalaby, MD, MSc, PhD 2020-06-19
The Development of Pancreatic Injury in the Course of Severe Acute Respiratory Syndrome Coronavirus-2 Infection Coronavirus disease 19 infection, Pancreas injury, Viral pneumonia biochemical analysis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Usak University, Turkey Turkey 2020-03-01 2020-06-12 NCT04433754, USAKU-CEVDET2 Phase Not Applicable Completed 1 3 Months 500 Cevdet Duran 2020-06-18
Clinical study to evaluate the efficiency of specific antibody against SARS-CoV-2 Coronavirus disease 19 infection antibody tests alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yokohama City University Japan Agency for Medical Research and Development Japan 2020-06-22 UMIN000040744 Phase Not Applicable Recruiting 1 5000 Mie Tsuchiya, tomoyuki miyazaki 2020-06-18
Maternal Psychological Implications of Covid-19 Pandemic and Possible Effect on Anesthetic Management Coronavirus disease 19 infection 38-questions questionnaire alone, GAD-7 general anxiety disorder scale alone, PHQ-9 depression scale alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) General and Maternity Hospital of Athens Elena Venizelou Greece 2020-05-15 2020-12-31 MATERNAL COVID 19, NCT04432948 Phase Not Applicable Recruiting 1 7 Months 200 Georgia Micha, Dr 2020-06-18
BNP, Serum Troponin and D-dimer as Risk Factors in Patients With COVID-19 Coronavirus disease 19 infection serum sampling alone Assiut University Egypt 2020-07-01 2021-09-01 CARDIAC MARKERS IN COVID-19, NCT04433026 Phase Not Applicable Not yet recruiting 1 14 Months 90 Areej Osama Ali Mohammed Saleh, Areej Saleh 2020-06-18
A clinical study to assess Tempol for the treatment of subjects with COVID-19 Coronavirus disease 19 infection Tempol (oral, radiotherapy-induced toxicities), Matrix Biomed alone Superoxide dismutase modulator Adamis Pharmaceuticals Corp Phase Not Applicable Planned 0 2020-06-17
Assessment of Mortality Rates in SARS-CoV-2 Infected Populations Treated With Repurposed Medications Coronavirus disease 19 infection Variable regimens including azithromycin , chloroquine , hydroxychloroquine Tabula Rasa HealthCare Inc US 2020-06-15 2021-05-31 COVID-19_TRHCPRESCRIBEWELLNESS, NCT04432350 Phase Not Applicable Not yet recruiting 1 11 Months 50000 Pamela Dow, MS, Veronique Michaud, Veronique Michaud, PhD 2020-06-18
A Phase III trial of COVID-19 vaccine for COVID-19 patients Coronavirus disease 19 infection COVID-19 vaccine (inactivated, Vero cells/intramuscular), Wuhan Institute of Biological Products/Wuhan Institute of Virology, CAS alone Wuhan Institute of Biological Products Co Ltd Phase 3 Clinical Planned 0 2020-06-18
Effect of Opuntia Cactus extract in patients with Covid-19 Coronavirus disease 19 infection, Headache, Myalgia Cactus Opuntia alone, standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Alborz University of Medical Science Iran 2020-07-10 IR.ABZUMS.REC.1399.024, IRCT20200504047298N2 Phase 3 Clinical Not yet recruiting 1 48 Zeinab Siami 2020-06-19
Patients Preferences About Rescheduling Colonoscopies Delayed Due to COVID-19: Cross-Sectional Study Colon tumor, Coronavirus disease 19 infection Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Massachusetts General Hospital US 2020-06-09 2021-04-30 2020P001579-1, NCT04432870 Phase Not Applicable Recruiting 1 10 Months 200 Karen Sepucha, PhD 2020-06-18
COVINOSE: Prospective diagnosis of Covid-19 infection using exhaled breath analysis by electronic nose Coronavirus disease 19 infection eNose alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Leiden University Medical Center Netherlands 2020-04-17 2020-12-31 COVINOSE, NL8694 Phase Not Applicable Recruiting 1 8 Months 200 Geert Groeneveld 2020-06-18
Phase II trial of Rejuveinix for Covid-19 patients Coronavirus disease 19 infection Rejuveinix alone Reven LLC Phase 2 Clinical Planned 0 2020-06-18
Extracorporeal membrane oxygenation in patients with coronavirus disease 2019 Coronavirus disease 19 infection Extracorporeal membrane oxygenation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Amsterdam UMC Netherlands 2020-03-01 2020-12-31 NL8706 Phase Not Applicable Recruiting 1 10 Months 200 Alexander Vlaar 2020-06-18
Quality of life in patients with suspected COVID-19 Coronavirus disease 19 infection Centre of expertise for chronic organ failure Netherlands 2020-06-04 2020-12-01 NL8705 Phase Not Applicable Recruiting 1 5 Months 10000 Martijn Spruit 2020-06-18
A clinical trial of mRNA vaccine (COVID-19), University of Tokyo/Daiichi-Sankyo for the potential treatment of COVID-19 infection Coronavirus disease 19 infection mRNA vaccine (COVID-19), University of Tokyo/Daiichi-Sankyo alone Daiichi Sankyo Co Ltd 2021-03-31 Phase Not Applicable Planned 0 2020-06-17
A study to assess the effect of PIKfyve inhibitors for the treatment of COVID-19 infection Coronavirus disease 19 infection PIKfyve inhibitors, Verge Genomics Inc alone Verge Genomics Inc Phase Not Applicable Planned 0 2020-06-17
PPE, COVID-19, HCW Coronavirus disease 19 infection personal protective equipment alone Universiti Malaysia Sarawak Malaysia 2020-05-06 2020-09-30 54908, NMRR-20-878-54908 Phase Not Applicable Not yet recruiting 35 4 Months Haniza Binti Sahdi, Nurul Fatiha binti Zuraidi 2020-06-17
Effects of patients' vision and emotions on covid-19 Coronavirus disease 19 infection, Depression, Vision disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Universiti Kebangsaan Malaysia Malaysia 2020-06-15 54953, NMRR-20-1123-54953 Phase Not Applicable Status not specified 2 DR Bannu A/P Jayallan, Dr. Nor Fariza Ngah 2020-06-17
Personality traits, depression, work stress, frontliners, Covid-19 Acute stress disorder, Coronavirus disease 19 infection, Depression Tuanku Jaafar Hospital Malaysia 2020-06-15 2020-12-31 54720, NMRR-20-875-54720 Phase Not Applicable Status not specified 1 6 Months Hj. Binaw Samad 2020-06-17
Incidence of ADR Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Sungai Buloh Malaysia 2020-06-09 55048, NMRR-20-1120-55048 Phase Not Applicable Status not specified 1 2020-06-17
ICRAD: ICRAD Coronavirus disease 19 infection, Rheumatoid arthritis Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sarawak General Hospital Malaysia 2020-07-01 2021-01-01 55262, ICRAD, NMRR-20-1116-55262 Phase Not Applicable Not yet recruiting 1 6 Months 15 Dr Sharifah Aishah bt Wan Mohamad Akba 2020-06-16
Efficacy of a new COVID-19 treatment Coronavirus disease 19 infection artesunate alone, artesunate plus vitamin C Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Malagasy government An Oasis of Healing in Mesa, The LifeCo, University of Mauritius Madagascar 2020-04-29 2020-09-29 PACTR202006899597082 Phase 2 Clinical Not yet recruiting 1 5 Months 60 MIORAMALALA Sedera, RAKOTO Rafanomezantsoa, RAKOTOARIVELO Rivonirina Andry, RAKOTOSAONA Riana, RAKOTOVAO Andriamiadana Luc, RAMANITRAHASIMBOLA David, RAPELANORO RABENJA Fahafahantsoa, RATSIMBASOA Claude Arsene 2020-06-19
Children with disability during the COVID-19 outbreak Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of Hong Kong Hong Kong 2020-03-23 HKUCTR-2872, UW 20-178, protocol v1-20200306 Phase Not Applicable Not yet recruiting 1 1356 Dr. Wan-yee Winnie Tso, HKUCTR Administrator 2020-06-17
RoKiCo: Prospective study to evaluate immunity to SARS-CoV2 in mothers with children in child-care facilities Coronavirus disease 19 infection biological sampling alone, polymerase chain reaction alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Universitätsmedizin Rostock Germany 2020-04-23 A 2020-0090, DRKS00021614, RoKiCo Phase Not Applicable Recruiting 1 400 Dagmar Michel-Lubs, Emil C. Reisinger 2020-06-17
Effects of COVID-19 on lung function and gas exchange Coronavirus disease 19 infection, Interstitial lung disease, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gesellschaft für Tauch- und Überdruckmedizin e.V, University Hospital, Bonn Klinik f. Lungenheilkunde und Beatmungsmedizin, Rhein-Maas Klinikum GmbH Germany 2020-06-16 179/20, DRKS00022082 Phase Not Applicable Not yet recruiting 1 124 Ivanna Rühl, Lars Eichhorn 2020-06-17
PROFLO: Could prone positioning increase lung function for patients with severe COVID-19 infection? Coronavirus disease 19 infection, Hypoxia, Respiratory failure, Viral pneumonia high flow nasal cannula alone, noninvasive ventilation alone, prone positioning alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Uppsala County Council University Hospital of Uppsala Sweden 2020-04-20 2021-06-25 1, ISRCTN54917435, PROFLO Phase Not Applicable Not yet recruiting 2 14 Months 240 Dr Rosen 2020-06-17
Influence of the Covid-19 pandemic on the patient mix in German emergency departments Coronavirus disease 19 infection BundeswehrKrankenhaus Ulm Klinikum WolfsburgZentrale Notfallaufnahme, Otto-von-Guericke-Universität Magdeburg, Universitätsklinik für Unfallchirurgie,AKTIN-Notaufnahmeregister, University Hospital Magdeburg, University Hospital, Aachen Germany 2020-07-01 160/15, DRKS00022188 Phase Not Applicable Not yet recruiting 1 500000 Martin Kulla, Wiebke Schirrmeister 2020-06-17
Exploratory Study Of the Therapeutic Effect and Safety Of Rectal Ozone therapyin Patients Positive To SARS-CoV 2 With Mild To Moderate Symptoms (COVID-19) Coronavirus disease 19 infection conventional therapy alone, rectal ozone therapy alone, Variable regimens including Chloroquine , Heberferon , lopinavir + ritonavir , oseltamivir Exo-alpha sialidase inhibitor, HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Center for Scientific Research, Cuba Cuba 2020-06-08 2020-08-23 OZO-001, RPCEC00000320 Phase Not Applicable Not yet recruiting 1 2 Months Suarez Iznaga, Zamora Rodriguez 2020-06-19
Efficacy and Safety of Sofosbuvir/Daclatasvir treatment in COVID-19: A randomized, controlled study Coronavirus disease 19 infection, Viral pneumonia Standard of care therapy alone, Daktavera plus Gratisovir Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) PHARCO CORPORATE Egypt 2020-06-20 DRKS00022203, IRB0000687, U1111-1253-0458 Phase 2/Phase 3 Clinical Not yet recruiting 1 90 Mostafa Yakoot 2020-06-17
The role of children in transmission of COVID19 pandemic: Two case series in Malaysia Coronavirus disease 19 infection Hospital Sungai Buloh Malaysia 2020-06-01 2020-08-06 NMRR-20-1087-55233 Phase Not Applicable Status not specified 1 2 Months Dr LIM SOK BEE 2020-06-16
Approachs and issues on Corona Disaster for EAP Coronavirus disease 19 infection Psychological education alone Healthy volunteers accepted ADVANTAGE Risk Management Co., Ltd. Japan 2020-06-15 UMIN000040762 Phase Not Applicable Not yet recruiting 1 100 Suzuki Junya 2020-06-16
Covid19HCW: Prevalence of seroconversion of COVID-19 among healthcare worker Coronavirus disease 19 infection RT-PCR test  alone, seroconversion test kits alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HOSPITAL QUEEN ELIZABETH II Malaysia 2020-05-11 2020-07-31 Covid19HCW, NMRR-20-885-54906 Phase Not Applicable Not yet recruiting 1 2 Months Dr Yen Chia How 2020-06-18
Children During the COVID-19 Outbreak Coronavirus disease 19 infection Preschool Children (2-5 yrs), Children (6-12 yrs) The University of Hong Kong Community Child Health Unit Hong Kong 2020-03-23 HKUCTR-2871, UW 20-177, v1-20200305 Phase Not Applicable Not yet recruiting 1 1356 Dr. Winnie Tso, HKUCTR Administrator 2020-06-16
Scientific guidance for risk-control and prevention of COVID-19 in professional soccer-players in Austria Coronavirus disease 19 infection RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Paracelsus Medical University Austria 2020-05-18 415-EP/73/820-2020, DRKS00022166 Phase Not Applicable Recruiting 1 250 Dagmar Schaffler 2020-06-17
A real-time national survey OF COVID-19 in hemoglobinopathy and rare inherited anemia patients Anemia, Coronavirus disease 19 infection, Sickle cell anemia, Thalassemia Queen Mary University of London UK Phase Not Applicable Status not specified 1 2020-06-16
GI IN COVID-19 Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Queen Elizabeth Malaysia 2020-05-18 2020-12-31 54764, NMRR-20-869-54764 Phase Not Applicable Recruiting 1 7 Months 200 Dr Ho Yoke Fun 2020-06-17
Psychosocial experiences among quarantined healthcare workers Coronavirus disease 19 infection Universiti Malaysia Sarawak Malaysia 2020-07-01 2020-09-30 54833, NMRR-20-1144-54833 Phase Not Applicable Not yet recruiting 2 3 Months Prof. Chew Keng Sheng 2020-06-17
Studying tobacco use and quitting behavior due to the coronavirus lockdown in India Coronavirus disease 19 infection interviewer-administered telephone-based survey alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HRIDAY, Public Health Foundation of India University of Edinburgh India 2020-06-20 CTRI/2020/06/025850, HMSC proposal ref id: 2020-9500 Phase Not Applicable Not yet recruiting 1 800 Dr Monika Arora, Prof K Srinath Reddy 2020-06-18
RNB in UPUMS, Saifai Coronavirus disease 19 infection RNB (Raj Nirvan Bati) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Uttar Pradesh University of Medical Sciences India 2020-06-14 CTRI/2020/06/025852 Phase 1/Phase 2 Clinical Not yet recruiting 1 Dr Raj Kumar 2020-06-17
Mental Health of children during COVID-19 Pandemic Coronavirus disease 19 infection Children (6-12 yrs), Adolescents (13-17 yrs) ESI Post Graduate Institute of Medical Science and Research (PGIMSR) India 2020-06-17 CTRI/2020/06/025853 Phase Not Applicable Not yet recruiting 1 100 Jyoti Bagla, Mahima Rajan 2020-06-17
BCG for COVID-19: BCG Vaccination against COVID-19 Coronavirus disease 19 infection, Respiratory disease BCG vaccine alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Indian Council of Medical Research India 2020-06-25 BCG for COVID-19, CTRI/2020/06/025854, Version 3.2 Phase 4 Clinical Not yet recruiting 6 1450 C Padmapriyadarsini, Dr Anant Mohan, Dr Asha Keetharam, Dr C Padmapriyadarsini, Dr R R Tiwari, Dr Rujuta Hadaye, Dr Toteja, Srikanth Tripathy 2020-06-17
FLARE: A randomised, double-blind, 2×2 factorial placebo-controlled trial on the saftey and efficacy Favipiravir, lopinavir/ritonavir combination therapy in early antiviral therapy in COVID-19 infection Coronavirus disease 19 infection favipiravir plus lopinavir + ritonavir HIV protease inhibitor, RNA polymerase inhibitor University of London LifeArc UK FLARE Phase Not Applicable Status not specified 1 2020-06-16
Short-term Outcome of COVID-19 Surgical Patients: Case-series of a High-risk Area Community Hospital Coronavirus disease 19 infection surgical procedure alone Azienda Socio Sanitaria Territoriale di Lodi Italy 2020-05-01 2020-05-30 COVID19NR1, NCT04430062 Phase Not Applicable Completed 1 14 Michele Ballabio 2020-06-18
Clinical Analysis of Patients Hospitalized Due To COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) TNMC and BYL Nair Hospital India 2020-06-21 CTRI/2020/06/025848 Phase Not Applicable Not yet recruiting 1 1500 Minal Harde, Rakesh Bhadade 2020-06-17
Study to Evaluate the Safety and Efficacy of a Combination of Nitazoxanide and Hydroxychloroquine Versus Hydroxychloroquine Alone in COVID-19 Patients Coronavirus disease 19 infection hydroxychloroquine plus nitazoxanide Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Dr Reddy's Laboratories Ltd India 2020-06-15 CTRI/2020/06/025849, CVD-19-CD-001 Phase 2 Clinical Not yet recruiting 1 158 D Mallikarjuna Rao, Dr Apurva Agarwal 2020-06-17
Safety, Tolerability and Efficacy of Nangibotide in Mechanically Ventilated Patients With COVID-19 and Features of Systemic Inflammation Coronavirus disease 19 infection, Inflammatory disease, Respiratory failure nangibotide alone, standard of care alone TREM receptor 1 antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Inotrem SA France 2020-06-30 2021-03-31 MOT-C-204, NCT04429334 Phase 2 Clinical Not yet recruiting 1 9 Months 60 Jean-Jacques Garaud, MD, Sébastien Gibot, MD 2020-06-17
Pre-Identified Homoeopathic Medicines In Asymptomatic Covid -19 Individuals Receiving Standard Treatment Protocol Coronavirus disease 19 infection Standard treatment alone, Variable regimens including Arsenicum album 30 , Bryonia 30 , Camphora 1M Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Central Council for Research in Homoeopathy India 2020-06-22 CTRI/2020/06/025844 Phase 2/Phase 3 Clinical Not yet recruiting 1 Dr Anil Khurana, Dr Varanasi Roja 2020-06-16
Registry for a Cardiovascular Patient Who COVID-19 Infection Acute coronary syndrome, Cardiac arrest, Coronavirus disease 19 infection, Heart arrhythmia, Myocarditis transthoracic echocardiography alone, ultrasound alone Hamad Medical Corp Qatar 2020-06-02 2020-12-31 MRC-05-113, NCT04430374 Phase Not Applicable Recruiting 1 6 Months 100 DR.Jassim Alsuwaidi Senior Consultant, Dr.Jassim Alsuwaidi Senior Consultant, MRC 2020-06-16
COVIpreg-UK: Studying the immune response and long-term morbidity of COVID-19 infection in pregnancy Coronavirus disease 19 infection Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Queen Mary University of London February Foundation UK 2020-05-07 2022-06-06 COVIpreg-UK, IRAS 283699, ISRCTN93266696 Phase Not Applicable Recruiting 1 25 Months 200 Dr Dodds, Dr Stamatina Iliodromiti 2020-06-16
A phase III trial of Inactivated vaccine (COVID-19), Sinovac Biotech for COVID-19 Coronavirus disease 19 infection CoronaVac alone Instituto Butantan, Sinovac Biotech Ltd Brazil Phase 3 Clinical Planned 1 2020-06-18
COVID-AIIMS: Low Dose Radiation Therapy for COVID-19 Coronavirus disease 19 infection, Viral pneumonia low dose radiation therapy (70 cGy) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences India 2020-06-13 COVID-AIIMS, CTRI/2020/06/025862, LDRT-Covid-19 Phase 1 Clinical Recruiting 1 10 Daya Nand Sharma 2020-06-19
Scientific evaluation of Immuno-modulatory effects of Ayush interventions on normal healthy and high-risk individuals in context with COVID-19 pandemic: An open-level study Coronavirus disease 19 infection Anu Taila put alone, Variable regimens including Amritadi Guggul , Ashwagandha Churna , Ashwagandha Vati , Ayush Raksha Kwath , Madhyashti Churna , Pippali Churna , Pippalimool Churna , Sanshmani Vaati , Shunthi Churna , kwath churna Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Department of Ayush Uttarakhand India 2020-06-20 CTRI/2020/06/025861 Phase 3 Clinical Not yet recruiting 9 500 Dr Alok Kumar Shukla, Dr Ashok Kumar Tiwari, Dr Avnish Kumar Upadhyay, Dr Deshraj Singh, Dr Jaideep Singh Bisht, Dr Krishna Kant Pandey, Dr Pankaj Kumar, Dr Rakesh Kumar Agarwal, Dr Sandeep Kumar, Dr Saroj Kumar Mishra, Dr Sunil Kumar Raturi, Dr Swastik Suresh 2020-06-19
EPIC 19: Observational study on suspected COVID 19 patients admitted to ICU Coronavirus disease 19 infection, Respiratory disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Johns Medical College India 2020-06-22 CTRI/2020/06/025858, EPIC 19 Phase Not Applicable Not yet recruiting 1 500 Dr Amarja Ashok Havaldar 2020-06-19
CELMA: Safety and Efficacy of Mesenchymal Stem Cells in the Management of Severe COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia Umbilical cord derived mesenchymal stem cells alone, Usual treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Trustem Fundación Universitaria de Ciencias de la Salud, Hospital Infantil Universitario de San Jose, Hospital de San Jose 2020-07-31 2020-11-30 202001, CELMA, NCT04429763 Phase 2 Clinical Not yet recruiting 0 4 Months 30 Carlos Escobar-Soto, MD, PhD, Carolina Araque, MD, Esp, Guillermo Sánchez-Vanegas, MD, PhD, Jhon Jaime Sprockel Díaz, MD, Esp 2020-06-16
Safety of TY-027, a Treatment for COVID-19, in Humans Coronavirus disease 19 infection TY-027, Tychan alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Tychan Pte Ltd Singapore 2020-06-09 2021-01-31 NCT04429529, SCT-001 Phase 1 Clinical Recruiting 1 7 Months 25 Anjali Baglody, MSc, Bo Hong Tay, Jenny Low, MBBS, Justin Ng, PhD, Shayne Lin 2020-06-17
LCECS: Development and Application of a Low-Cost Ear-Contactless Stethoscope Powered by Raspberry Pi and Python Coronavirus disease 19 infection Low-Cost Ear-Contactless Stethoscope alone Healthy volunteers accepted Shengjing Hospital of China Medical University China 2020-06-12 2021-06-12 ChiCTR2000033830, LCECS Phase Not Applicable Not yet recruiting 1 12 Months 12 Chuan Yang 2020-06-17
A phase III clinical study of SARS-CoV-2 vaccine, Ad26.COV2-S for the treatment of COVID-19 Coronavirus disease 19 infection SARS-CoV-2 recombinant adenoviral vector vaccine (AdVac/PER.C6, COVID-19), Johnson & Johnson/Biomedical Advanced Research and Development Authority/Beth Israel Deaconess Medical Center alone Johnson & Johnson Phase 3 Clinical Planned 0 2020-06-15
COMETE-19: Covid-19 at the Regional Medical Center Metz-Thionville: a Descriptive Study Coronavirus disease 19 infection Centre Hospitalier Régional Metz-Thionville France 2020-03-01 2021-06-30 2020-02OBS-CHRMT, COMETE-19, NCT04430322 Phase Not Applicable Recruiting 1 16 Months 330 Nadia OUAMARA, Rostane GACI, MD, Vincent DINOT 2020-06-19
Hydroxychloroquine Use in Hospitalized Patients With COVID-19: Impact on Progression to Severe or Critical Disease Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) WellStar Health System US 2020-05-07 2020-12-07 1604885, NCT04429867 Phase 4 Clinical No longer recruiting 1 7 Months 700 2020-06-18
OpMiCoV: Explorative Study of the Association of Oropharyngeal Microbiota Profiles with SARS-CoV-2 Infection and COVID-19 disease Coronavirus disease 19 infection, Upper respiratory tract infection, Viral pneumonia Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Deutsches Krebsforschungszentrum Germany 2020-04-02 DRKS00021424, OpMiCoV, S-194/2020, U1111-1253-4873 Phase Not Applicable No longer recruiting 1 360 Christoph Stein-Thoeringer 2020-06-17
Epidemiological and Demographic Data From 150 Patients Diagnosed With Coronavirus Disease 2019 Pneumonia Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Etfal Hospital Turkey 2020-05-15 2020-06-05 DM3334, NCT04430023 Phase Not Applicable Completed 1 150 AYŞE SÜRHAN ÇINAR, ayse cinar 2020-06-18
Health Professional Exposure Assessment to Covid-19 (SERODRON) Coronavirus disease 19 infection RT-PCR test alone, blood sampling alone, serological test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier de Tourcoing France 2020-06-30 2020-12-31 NCT04429724, RIPH_2020_8 Phase Not Applicable Not yet recruiting 3 6 Months 6000 Pierre PATOZ, PharmD, SIVERY, Solange TREHOUX, PhD, VACHEE 2020-06-17
MAGIC: Impact of Smoking and Nicotine on the Risk of Being Infected With COVID-19 Coronavirus disease 19 infection, Nicotine dependence nicotine substitute therapy alone, serological test alone, smoking cessation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France France 2020-07-01 2021-04-01 2020-A01681-38, MAGIC, NCT04429815 Phase Not Applicable Not yet recruiting 1 9 Months 489 Christian Rabaud 2020-06-16
A study to predict the disease progression in COVID-19 patients by analyzing blood samples of these patients from using high-throughput mass spectrometry platform Coronavirus disease 19 infection high-throughput mass spectrometry alone Charite Universitaetsmedizin Berlin The Francis Crick Institute UK Phase Not Applicable Status not specified 1 31 Prof. Dr. Markus Ralser 2020-06-15
A phase I clinical study to assess TP-508 in the treatment of patients with COVID-19 Coronavirus disease 19 infection rusalatide alone Factor IIa modulator Chrysalis BioTechnology Inc National Institute of Allergy and Infectious Diseases Phase 1 Clinical Planned 0 2020-06-15
Follow-up of COVID-19 Positive Patients Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bangladesh Health Professions Institute Bangladesh 2020-06-23 CTRI/2020/06/025857 Phase Not Applicable Not yet recruiting 1 200 K M Amran Hossain, Md. Obaidul Haque 2020-06-16
SARS-CoV2 IIF: Prospective Assay for SARS-CoV-2 Antibody Detection Indirectly by Immunofluorescence Coronavirus disease 19 infection SARS-CoV2 ELISA alone, immunofluorescence (SARS-CoV2 IIF ) alone, qPCR assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Szeged Biological Research Center of the Hungarian Academy of Sciences Hungary 2020-05-30 2020-12-31 NCT04429620, SARS-COV-2-IIF-002, SARS-CoV2 IIF Phase Not Applicable Recruiting 1 7 Months 100 Dávid Pintér, Pharm. D., Katalin Burián, MD 2020-06-16
A phase II clinical study to assess TP-508 in the treatment of patients with COVID-19 Coronavirus disease 19 infection rusalatide alone Factor IIa modulator Chrysalis BioTechnology Inc, National Institute of Allergy and Infectious Diseases Phase 2 Clinical Planned 0 2020-06-15
Evaluation of siddha regimen in the management of covid 19 Coronavirus disease 19 infection Variable regimens including Adathodai Manapagu , Kabasura kudineer , Thippili Rasayanam , Vasantha kusumakaram Mathirai Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Government Siddha Medical College India 2020-06-25 CTRI/2020/06/025856 Phase 2 Clinical Not yet recruiting 1 Dr N Anbu, Dr S M Chitra 2020-06-16
A retrospective, cohort, uncontrolled, exploratory study to evaluate the effects of treatment with interferon-alpha2b in the confirmed COVID-19 patients in Wuhan, China Coronavirus disease 19 infection interferon alpha-2b (COVID-19, inhaled), Altum Pharmaceuticals alone, arbidol plus interferon alpha-2b (COVID-19, inhaled), Altum Pharmaceuticals Interferon alpha ligand modulator Union Hospital Tongji Medical School Huazhong University Of Science & Technology China Phase Not Applicable Status not specified 1 77 2020-06-15
Effect of AYUSH 64 in COVID 19 Coronavirus disease 19 infection AYUSH 64 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Institute for Post Graduate Teaching and Research in Ayurveda India 2020-06-15 CTRI/2020/06/025855 Phase 2 Clinical Not yet recruiting 2 200 Dr Mandip Goyal, Dr Sagar M Bhinde, Dr Yagnik Chotala, Prof Anup Thakar 2020-06-15
SPIKE-1: A Randomized, Phase II/III trial to assess the use of camostat in reducing the clinical progression of COVID-19 by blocking SARS-CoV-2 Spike protein-initiated membrane fusion Coronavirus disease 19 infection camostat mesylate alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor University of Edinburgh LifeArc UK SPIKE-1 Phase 2/Phase 3 Clinical Status not specified 1 2020-06-16
Serum protein marker in patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Healthy volunteers accepted, Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Chongqing People'S Hospital China 2020-02-01 2022-02-01 ChiCTR2000033872 Phase 0 Clinical No longer recruiting 1 24 Months 350 Ling Yan, Pu Liao 2020-06-16
Efficacy, Safety, Tolerability, and Biomarkers of MN-166 (Ibudilast) in Patients Hospitalized With COVID-19 and at Risk for ARDS Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia ibudilast (oral, neuropathic pain/opiate dependence/neurodegeneration/TBI/drug dependence/acute respiratory distress syndrome/COVID-19), MediciNova alone IL-6 receptor antagonist, Interleukin-1 beta ligand inhibitor, Macrophage migration inhibitory factor inhibitor, PDE 10 inhibitor, PDE 4 inhibitor, TLR-4 antagonist, TNF alpha ligand inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) MediciNova Inc, Yale School of Medicine US 2020-07-31 2021-12-01 MN-166-COVID-19-201, NCT04429555 Phase 2 Clinical Not yet recruiting 1 16 Months 40 Dr. Geoffrey Chupp, Dr. Insoo Kang, Joanna Dojillo, MMsc, Kazuko Matsuda, MD PhD MPH, r. Maor Sauler 2020-06-16
A pilot study of baricitinib for treatment of bilateral COVID-19 pneumonia Coronavirus disease 19 infection, Viral pneumonia baricitinib alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Eli Lilly & Co, Imperial College London Italy Phase 2 Clinical Status not specified 1 4 2020-06-15
The efficacy and safety of convalescent plasma therapy in novel coronavirus pneumonia (COVID-19): A medical records based retrospective, cohort study Coronavirus disease 19 infection, Viral pneumonia convalescent plasma therap alone, non-convalescent plasma therapy alone Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tongji Hospital, Huazhong University of Science and Technology China 2020-06-12 2021-06-11 ChiCTR2000033798 Phase Not Applicable Not yet recruiting 1 12 Months 150 Minghao Fang, Yi Bian 2020-06-16
Cerebral Compliance Impairment in COVID-19 Brain disease, Coronavirus disease 19 infection Brain4care (B4C) sensor alone, Transcranial Doppler alone Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Sao Paulo Brazil 2020-05-01 2020-07-31 31750820.1.0000.0068, NCT04429477 Phase Not Applicable Recruiting 1 3 Months 50 Gustavo Frigieri, PhD, Sergio Brasil, MD, Sergio Brasil, PhD 2020-06-16
DAWN-Plasma: Donated Antibodies Working Against nCoV Coronavirus disease 19 infection, Lower respiratory tract infection, Upper respiratory tract inflammation Convalescent plasma alone, Standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitaire Ziekenhuizen Leuven Federal Knowledge Centre (KCE) Belgium 2020-05-02 2021-11-02 DAWN-Plasma, NCT04429854, S63992 Phase 2 Clinical Recruiting 14 18 Months 483 Bernard Bouckaert, MD, Clotilde Visée, MD, Geert Meyfroidt, MD, PhD, Georgala Aspasia, MD, Jean Yombi, MD, Laurent Jadot, MD, Lucie Seyler, MD, Matthias Leys, MD, Michel Moutschen, MD, Nicolas Dauby, MD, Niels Van Regenmortel, MD, Timothy Devos, MD,PHD 2020-06-16
A phase II clinical study of self-amplifying RNA vaccine (im, COVID-19), Imperial College London for the potential prevention of SARS-CoV-2 infection (COVID-19) Coronavirus disease 19 infection self-amplifying RNA vaccine (im, COVID-19), Imperial College London alone COVID19 Spike glycoprotein inhibitor Imperial College London UK Government 2020-06-30 Phase 2 Clinical Planned 0 2020-06-15
CGM-ISO: Remote Continues Glucose Monitoring During the COVID-19 Pandemic in Quarantined Hospitalized Patients Coronavirus disease 19 infection, Diabetes mellitus, Viral pneumonia CGM stratification alone, Dexcom G6 alone, Standard care with fingerprick glucose test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nordsjaellands Hospital Denmark 2020-05-25 2021-05-25 CGM-ISO, H-20025305, NCT04430608 Phase Not Applicable Recruiting 1 12 Months 72 Carina Klarskov, MD, Peter L. Kristensen, MD, ph.D 2020-06-16
HAD-Covid: Impact of Covid-19 Restrictive Measure on Anxiety, Depression and PTSD for Relatives of ICU Patients Anxiety disorder, Coronavirus disease 19 infection, Depression, Post traumatic stress disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Clermont-Ferrand France 2020-06-22 2022-01-22 2020 HAD-COVID, HAD-Covid, NCT04430049 Phase Not Applicable Not yet recruiting 11 19 Months 120 Alexandre Lautrette, MD, PhD, Anne Médard, MD, Arnaud Delahaye, MD, Christophe Leroy, MD, Edouard Soum, MD, Emmanuel Futier, MD,PhD, Jean-Etienne Bazin, MD, PhD, Lise Laclautre, Luc Jarrige, MD, Marie-Hélène Hausermann, MD, Nathanael Einsemann, Pierre-Marie Bertrand, MD, Ramin Ravan, MD, Russel Chabanne, MD, Sophie Cayot, MD, Thierry Gillard, MD 2020-06-16
COV003: A phase III study to investigate a vaccine against COVID-19 Coronavirus disease 19 infection AZD-1222 alone, AZD-1222 plus paracetamol COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Federal University of Sao Paulo, University of Oxford The Lemann Foundation Brazil 2020-05-01 2021-07-31 COV003, COV003, ISRCTN89951424 Phase 3 Clinical Recruiting 1 15 Months 2000 Dr Peter O'Reilly 2020-06-16
CATALYST: An adaptive, rapid, open-label, phase II, multi-arm, multi-stage clinical trial to evaluate the efficacy of IZN-101 and CT-P13 in the treatment of hospitalized patients with severe COVID-19 infection Coronavirus disease 19 infection infliximab biosimilar, Celltrion/Nippon Kayaku/Hospira/Orion/EGIS Gyogyszergyar alone, namilumab alone, standard of care alone GM-CSF ligand inhibitor, TNF alpha ligand inhibitor, TNF binding agent NIHR Birmingham Biomedical Research Centre, The University of Birmingham, University Hospital Birmingham NHS Foundation Trust NIHR Biomedical Research Centre, Oxford, United Kingdom Research & Innovation, University College London, University of Oxford UK, US CATALYST Phase 2 Clinical Recruiting 2 160 Dr Ben Fisher, Dr Matt Rowland, Professor Duncan Richards 2020-06-17
A placebo-controlled trial to evaluate REGN-CoV2 for the prevention of COVID-19 in uninfected people with close exposure to a COVID-19 patient Coronavirus disease 19 infection REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Regeneron Pharmaceuticals Inc US 2020-06-11 Phase Not Applicable Recruiting 1 Dr. Suraj Saggar 2020-06-19
A placebo-controlled trial to evaluate REGN-CoV2 for the prevention of COVID-19 in uninfected people who are at high-risk of exposure Coronavirus disease 19 infection REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Regeneron Pharmaceuticals Inc US 2020-06-11 Phase Not Applicable Recruiting 1 Dr. Suraj Saggar 2020-06-19
ERNA: An intensive, longitudinal study on habit formation of hand washing behavior during the COVID-19 pandemic Coronavirus disease 19 infection hand washing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical School Berlin Berlin Free University Germany 2020-06-25 DRKS00022067, ERNA, MSB-2020/36 Phase Not Applicable Not yet recruiting 5 134 Antonia Domke, Lena Fleig 2020-06-15
Ivermectin versus Placebo for the Treatment of Patients With Mild to Moderate COVID-19 Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sheba Medical Center Israel 2020-05-12 2020-10-31 NCT04429711, SHEBA-20-7156-ES-CTIL Phase 2 Clinical Recruiting 1 5 Months 100 Asaf Biber, Dr., Eli Schwartz, M.D, Eli Schwartz, Prof., Prof. Eli Schwartz MD, DTMH 2020-06-17
A clincial study to assess immune response of QuadraMune in healthy subjects for the prevention of COVID-19 Coronavirus disease 19 infection QuadraMune alone Healthy volunteers accepted Therapeutics Solutions International Inc Phase Not Applicable Status not specified 0 8 Dr. James Veltmeyer 2020-06-15
Multicenter, adaptive, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of the drug ХС-221, 100 mg tablets, in patients with COVID-19 Coronavirus disease 19 infection XC-221 alone RSV Therapeutics LLC Russian Federation 2020-06-09 2021-12-31 ХС221-03-02-2020 Phase 3 Clinical Status not specified 7 18 Months 150 2020-06-15
Post-traumatic Stress Disease in Health Workers During COVID-19 Pandemia Coronavirus disease 19 infection, Post traumatic stress disorder Maslach Burnout Inventory (MBI) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) IRCCS AOU San Martino – IST Italy 2020-03-01 2020-07-01 NCT04424771, PTSD-COVID-19 Phase Not Applicable Recruiting 2 4 Months 800 Eleonora Giuntoli, MD, Eleonora Guaitoli, Eleonora Guaitoli, MD, Fabio Barra, Fabio Barra, MD 2020-06-15
AKI C19 HKL: Acute kidney injury and renal replacement therapy: incidence and outcome in COVID-19 patients admitted to Hospital Kuala Lumpur Coronavirus disease 19 infection, Renal injury renal replacement therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Kuala Lumpur Malaysia 2020-06-15 2021-12-31 55036, AKI C19 HKL, AKI C19 HKL, NMRR-20-1090-55036 Phase Not Applicable Not yet recruiting 1 18 Months 371 Dr NURUL ZAYNAH BINTI NORDIN 2020-06-15
BLAZE-1: A Study of LY-3819253 (LY-CoV555) in Participants With Early Mild-to-Moderate COVID-19 Illness Coronavirus disease 19 infection LY-CoV555 alone COVID19 Spike glycoprotein modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eli Lilly & Co AbCellera Biologics Inc US 2020-06-13 2020-09-15 17947, BLAZE-1, J2W-MC-PYAB, NCT04427501 Phase 2 Clinical Recruiting 23 3 Months 400 A Blomkalns, Adam Schwartz, Andra Blomkalns, Carlos Malvestutto, DONALD PORETZ, David Pitrak, Erica Kaufman West, GERARD J CRINER, Gregory Huhn, Imad J Shawa, Jeffrey Glassberg, Katherine Belden, Kristin Highland, Mayur Ramesh, Michael L Dougan, Patrick Milligan, Peter Chen, Princy Kumar, Robert Gottlieb, V Stosor, Valentina Stosor, William A Fischer 2020-06-18
IDEA: Ivermectin, Aspirin, Dexametasone and Enoxaparin as Treatment of COVID-19 Coronavirus disease 19 infection, Viral pneumonia Variable regimens including aspirin , dexamethasone , enoxaparin sodium , ivermectin Chloride channel modulator, Low molecular weight heparin Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eurnekian Public Hospital Argentina 2020-05-01 2020-07-30 IDEA, IDEA, NCT04425863 Phase Not Applicable No longer recruiting 1 2 Months 10 Alfredo Secchi, M.D., Hector E Carvallo 2020-06-18
To Compare Videolaryngoscope Against Direct Laryngoscope for Intubation When Powered Air Purifying Respirator is Worn Anesthesia, Coronavirus disease 19 infection McGrath videolaryngoscope alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Singapore General Hospital Pte Ltd Duke-NUS Graduate Medical School Singapore 2020-06-01 2020-12-31 2020/2329, NCT04424953 Phase Not Applicable Not yet recruiting 1 7 Months 60 Qing Yuan Goh, M.Med (Anes), Zihui Tan, M.Med (Anes) 2020-06-16
Efficacy of Convalescent Plasma Therapy in Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Convalescent Plasma therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institute of Liver and Biliary Sciences, India India 2020-06-09 2021-05-30 ILBS-COVID-04, NCT04425915 Phase 3 Clinical Recruiting 3 11 Months 400 Dr Ankit Bhardwaj, Masters-CT, Dr Meenu Bajpai, MD, Dr Suresh Kumar, MD, Dr Vikas Dogra, MD 2020-06-15
Thorax Computed Tomography Severity Score and Outcome in COVID-19 Patients Coronavirus disease 19 infection, Viral pneumonia CT scan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tepecik Training and Research Hospital Turkey 2020-03-15 2020-07-15 2020/5-4, NCT04424849 Phase Not Applicable Recruiting 1 4 Months 40 Aykut Sarıtaş, Isıl K Guldogan, Işıl Köse Güldoğan, Kazim Rollas, Kazım Rollas, Naciye Sinem GEZER, Nimet Şenoğlu, Taner Çalışkan, Uğur Uzun, Yeliz Pekçevik, Çiler Zincircioğlu, İsa Sahar 2020-06-15
Cardiovascular Risk Factors and Severe COVID-19. A Nationwide, Registry-based, Case-control Study Cardiovascular disease, Coronavirus disease 19 infection, Hypertension, Non-insulin dependent diabetes, Obesity antidiabetic therapy alone, antihypertensive agent therapy alone, statin therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Karolinska Institutet Sweden 2020-03-01 2022-12-31 4, NCT04426084 Phase Not Applicable No longer recruiting 1 34 Months 22784 Per Svensson 2020-06-15
AiM Covid Self Monitoring Coronavirus disease 19 infection AiM Covid App alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aarogyam UK Mothers Touch Foundation, NMP Medical Research Institute, Warwick University India 2020-04-12 2020-05-28 AU015, NCT04425044 Phase Not Applicable Completed 2 1 Month 1000 Vishwes Kulkarni 2020-06-15
Thymosin Alpha 1 to Prevent COVID-19 Infection in Elderly Renal Dialysis Patients Coronavirus disease 19 infection thymalfasin alone Thymosin receptor agonist Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Inova Health Care Services DaVita Clinical Research, Nephrology Associates of Northern Virginia, Inc. US 2020-06-30 2021-06-30 ACW-1221958-1, NCT04428008 Phase 2 Clinical Not yet recruiting 1 12 Months 240 William B Ershler, MD, William B. Ershler 2020-06-18
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Study Evaluating Favipiravir in Treatment of COVID-19 Coronavirus disease 19 infection, Viral pneumonia favipiravir alone, supportive care alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Zhejiang Hisun Pharmaceutical Co Ltd Opera CRO China, Germany, Romania 2020-06-30 2020-09-30 HS216C17(MRCT), NCT04425460 Phase 3 Clinical Not yet recruiting 8 3 Months 256 Dionisio Barattini, MD Europe, Opera CRO, Emanuel Dogaru, CPM, Opera CRO 2020-06-16
COVID-19 ORL: Smell and Taste Disorders in COVID-19 Patients Coronavirus disease 19 infection, Taste disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-05-15 2020-09-30 COVID-19 ORL, COVID-19 ORL, NCT04427332 Phase Not Applicable Recruiting 1 4 Months 500 Dante Jean Garavello Werner Jean, Prof., Dante Jean Garavello Werner, Professor 2020-06-16
COVID_OFF: Detection of SARS-CoV-2 in Follicular Fluid and Cumulus-oocyte-complexes in COVID-19 Patients Coronavirus disease 19 infection Endometrial biopsy alone Female, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) CRG UZ Brussel Belgium 2020-06-15 2021-06-15 COVIDOFF001, COVID_OFF, NCT04425317 Phase Not Applicable Not yet recruiting 1 12 Months 20 Elsie Nulens, Liese Boudry, Liese Boudry, MD 2020-06-16
Masq-Aute: Evaluation of ARFC Masks Equipped With CF5 Filter in the Care Unit to Allow a Wider Distribution of FFP2 Masks (Covid-19) Coronavirus disease 19 infection ARFC mask alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Saint Etienne France 2020-04-29 2020-06-30 2020-A00817-32, 20CH073, Masq-Aute, NCT04427176 Phase Not Applicable Recruiting 1 2 Months 30 Andréa BUCHMULLER, MD, Bernard TARDY, MD PhD, Florence RANCON, CRA, Jean Luc PERROT, MD PhD, Jean-Luc PERROT, MD PhD 2020-06-15
TOLD: Trial of Open-Label Dipyridamole In Hospitalized Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure, Respiratory tract infection dipyridamole alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) UConn Health US 2020-05-03 2021-05-30 20-192-2.F, NCT04424901, TOLD Phase 2 Clinical Recruiting 1 12 Months 100 Bruce Liang, MD, Christopher Pickett, MD, Elizabeth Laska, RN, Eric Mortensen, MD, Jeffrey Aeschlimann, PharmD, Kevin Dieckhaus, MD, Mark Metersky, MD, Patti Keltonic, RN 2020-06-15
A phase Ia/Ib clinical trial of trans sodium crocetinate for the treatment of hospitalized COVID-19 patients displaying severe respiratory symptoms and low oxygen levels Coronavirus disease 19 infection trans sodium crocetinate alone ARENSIA Exploratory Medicine, Diffusion Pharmaceuticals LLC Romania 2020-06-30 Phase 1 Clinical Planned 1 Prof. Adrian Streinu-Cercel 2020-06-12
Vitamin A and COVID-19 Coronavirus disease 19 infection vitamin A alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Iran University of Medical Sciences Iran 2020-05-21 IR.IUMS.REC.1399.204, IRCT20200405046951N1 Phase 3 Clinical Recruiting 1 120 Azadeh Mottaghi 2020-06-15
Evaluation the effect of raltegravir and raltegravir/interferon beta combination on COVID-19 patients Coronavirus disease 19 infection Variable regimens including hydroxychloroquine , interferon beta , raltegravir HIV-1 integrase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jahrom University of Medical Iran 2020-06-19 IR.JUMS.REC.1399.028, IRCT20200412047042N1 Phase 3 Clinical Recruiting 1 60 Dr Kavous Solhjoo, Dr Rahim Raoufi, ِDr Samaneh Zolghadri 2020-06-19
Assessment of Thermal Condition of Health Workers Who Use Personal Protective Equipment From Biological Hazards During Their Work With COVID-19 Patients Coronavirus disease 19 infection Personal protective equipment alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Federal State Budgetary Scientific Institution 'Izmerov Research Institute of Occupational Health' Russian Federation 2020-06-03 2020-06-10 NCT04427267, PPE-02 Phase Not Applicable No longer recruiting 1 6 Andrey Mikhailovich Geregey 2020-06-17
VENTED COVID: Low Dose Whole Lung Radiation Therapy for Patients With COVID-19 and Respiratory Compromise Coronavirus disease 19 infection, Hypoxia, Lung inflammation, Respiratory disease, Viral pneumonia ultralow dose-whole lung radiation therapy (80 cGy) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ohio State University Comprehensive Cancer Center US 2020-06-30 2021-12-31 NCT04427566, VENTED, VENTED COVID Phase 2 Clinical Not yet recruiting 1 18 Months 24 Arnab Chakravarti, Kimberly Mahler 2020-06-17
VExCO: Mechanical ventilator for use in patients with respiratory failure due to Covid-19 Coronavirus disease 19 infection, Respiratory failure ventilator alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro Foundation for Research Financial Support in the State of Rio de Janeiro (FAPERJ) Brazil 2020-06-04 2020-06-11 4.063.224, CAAE: 31031920.2.0000.5257, RBR-2dxyx4, U1111-1252-8144, VExCO Phase Not Applicable Not yet recruiting 1 5 Diamantino Ribeiro Salgado 2020-06-16
HFNC Treatment in COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia high flow nasal cannula device alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Hamidiye Etfal Training and Research Hospital Turkey 2020-05-15 2020-06-05 5569, NCT04424836 Phase Not Applicable Recruiting 1 40 ayse su cinar, mustafa altinay, mustafa altınay, nebia peker 2020-06-17
Therapeutic Vaccine Trial of COVID-19 for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Coronavirus disease 19 infection Covax-19 alone Coronavirus spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Genecure LLC, Vaxine Pty Ltd 2020-07-31 2021-12-31 GC004, NCT04428073 Phase 1 Clinical Not yet recruiting 0 17 Months 32 Frank Tung, Ph.D 2020-06-19
Identification of Genetic Factors Determining Disease Course in the New Type of Coronavirus Infection, COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Szeged Hungary 2020-06-05 2021-07-31 COVID19_HUNGEN_001, NCT04426253 Phase Not Applicable No longer recruiting 11 13 Months 1000 Márta Széll, MD, Ph.D. 2020-06-15
Chloroquine + Losartan Compared to Chloroquine Alone for the Treatment of COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia chloroquine phosphate plus losartan Angiotensin II AT-1 receptor antagonist, Angiotensin II receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario Dr. Jose E. Gonzalez Mexico 2020-03-10 2020-08-30 IF20-00003, NCT04428268 Phase 2 Clinical Recruiting 1 5 Months 20 Adrian Camacho Ortiz, MD, Adrian Camacho, PhD, Adrian Camacho-Ortiz, PhD, Eduardo Pérez Alba, MD, Juan Diego Lecona García, MD, Laura Marina Nuzzolo Shihadeh, MD 2020-06-17
Autologous Adipose-derived Stem Cells (AdMSCs) for COVID-19 Coronavirus disease 19 infection AdMSCs (osteoarthritis/rheumatoid arthritis), CelltexTherapeutics alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Celltex Therapeutics Corp US 2020-06-20 2021-08-10 CTX0020-003, NCT04428801 Phase 2 Clinical Not yet recruiting 1 13 Months 200 Candy Eller, Derek W Guillory, MD. 2020-06-17
SERO-MARES: Prevalence and Risk Factors of SARS-CoV-2 Antibody Responses (COVID-19) Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital de Mataró Spain 2020-06-08 2021-06-30 NCT04425759, SERO-MARES, SERO-MARES (56/20) Phase Not Applicable Recruiting 2 12 Months 2400 Pere Clavé, MD, Pere Clavé, MD, PhD 2020-06-17
IVERCAR: Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 Coronavirus disease 19 infection personal protective equipment usage alone, Ivercass (ivermectin) plus iota carrageenan (Nasitral) Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eurnekian Public Hospital Argentina 2020-06-01 2020-08-30 IVERCAR, IVERCAR, NCT04425850 Phase Not Applicable No longer recruiting 1 2 Months 70 Hector E Carvallo 2020-06-18
BIG-C: Exploring Interventions for Glue Ear During Covid-19 Coronavirus disease 19 infection, Hearing loss, Otitis media Hear Glue Ear app (Cambridgeshire Community Services NHS Trust) alone, bone conduction headphone alone, microphone alone, telephone consultation alone, video consultation alone Preschool Children (2-5 yrs), Children (6-12 yrs) Cambridgeshire Community Services NHS Trust Cambridge University Hospitals NHS Foundation Trust UK 2020-06-22 2021-06-01 262816, BIG-C, NCT04427631 Phase Not Applicable Not yet recruiting 1 11 Months 20 Alison Sansome, BM BCh MA MRCPCH, Dr. Tamsin Brown, Tamsin M Holland Brown, MBBS MRCPCH, alison Sansome, MBBS MRCPCH 2020-06-15
The efficacy of barely-based traditional remedy on COVID-19 Coronavirus disease 19 infection Variable regimens including atazanavir + ritonavir , barley-based remedy , chloroquine phosphate , hydroxychloroquine , lopinavir + ritonavir HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University Iran 2020-05-13 IR.SBMU.RETECH.REC.1399.074, IRCT20180923041093N6 Phase 3 Clinical No longer recruiting 1 60 Mahmood Khodadoost, Roshanak Mokaberinejad 2020-06-19
COV-OB-ICU: Obesity and Mortality of Critically Ill Patients With COVID-19 Coronavirus disease 19 infection, Obesity, Respiratory failure, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Hospital, Nancy, France France 2020-05-12 2020-05-26 2020PI082, COV-OB-ICU, NCT04425213 Phase Not Applicable Completed 1 250 Olivier Ziegler, PU-PH 2020-06-17
Use of Remote Monitoring for COVID-19 Patient Coronavirus disease 19 infection LifeSignals Biosensor 1AX alone, Remote Patient Monitoring alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Montefiore Medical Center US 2020-06-05 2021-06-01 NCT04425720, PENDING Phase Not Applicable Not yet recruiting 1 11 Months 300 Jonathan Leff, MD, Singh Nair, PhD 2020-06-16
Early Prone Position on Coronavirus Disease 2019 Pneumonia (Prone Position) Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia conventional oxygen therapy alone, prone position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Etfal Hospital Turkey 2020-06-05 2020-06-15 NCT04427969, PP34 Phase Not Applicable Recruiting 1 40 ayse surhan cinar, mustafa altinay, nebia peker 2020-06-15
MI-COVID: Predictive Factors COVID-19 Patients Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-03-01 2021-05-31 MI-COVID, MI-COVID, NCT04427345 Phase Not Applicable Recruiting 1 15 Months 1000 Paolo Bonfanti, Paolo Bonfanti, Professor 2020-06-15
Saliva/Nares as Source of Detection for SARS-CoV-2 at NIH Coronavirus disease 19 infection COVID-19 screening alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institutes of Health Clinical Center US 2020-06-24 2021-06-01 20-CC-0128, 200128, NCT04424446 Phase Not Applicable Recruiting 1 11 Months 5000 Karen M Frank, M.D., Rebecca A Nebel, Ph.D. 2020-06-19
COVID-19 Antibodies Among Healthcare Workers Coronavirus disease 19 infection COVID-19 IgG/IgM rapid test Cassette test (Healgen Scientific, Houston, Texas, USA) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Universitario Dr. Jose E. Gonzalez Mexico 2020-05-05 2020-06-01 IF20-00008, NCT04425889 Phase Not Applicable Completed 1 156 Dr. Adrian Camacho-Ortiz 2020-06-15
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19 Coronavirus disease 19 infection Face mask alone, High-intensity oxygen therapy alone, Low-flow oxygen therapy alone, Mechanical ventilation alone, Nasal cannula alone, REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Regeneron Pharmaceuticals Inc US 2020-06-12 2021-03-03 NCT04426695, R10933-10987-COV-2066 Phase 1/Phase 2 Clinical Recruiting 1 8 Months 1860 Clinical Trial Management, Clinical Trials Administrator, Dr. Suraj Saggar 2020-06-17
DOLCI: Darunavir/Cobicistat versus Lopinavir/Ritonavir in COVID-19 Pneumonia in Qatar Coronavirus disease 19 infection, Viral pneumonia darunavir + cobicistat (fixed dose, HIV infection), Janssen R&D/ Gilead alone, lopinavir + ritonavir alone Cytochrome P450 3 inhibitor, HIV protease inhibitor, HIV-1 protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hamad Medical Corp Qatar 2020-03-01 2020-09-30 DOLCI, MRC-05-069, NCT04425382 Phase Not Applicable Recruiting 1 7 Months 200 Dr. Eman Elmekaty, PharmD 2020-06-15
A phase I trial of SARS-CoV-2 virus-neutralizing mAbs (COVID-19), AstraZeneca/ VUMC for SARS-CoV-2 virus Coronavirus disease 19 infection SARS-CoV-2 virus-neutralizing mAbs (COVID-19), AstraZeneca/ VUMC alone AstraZeneca plc US Department of Defense, Vanderbilt University Phase 1 Clinical Planned 0 2020-06-12
INHIXACOV19: Enoxaparin in COVID-19 Moderate-to-Severe Hospitalized Patients Coronavirus disease 19 infection, Multiple organ failure, Respiratory failure, Septic shock, Thrombosis, Viral pneumonia enoxaparin sodium biosimilar, Techdow alone, standard thromboprophylaxis alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Policlinico S.Orsola-Malpighi Italy 2020-05-22 2020-10-30 2020-001308-40, INHIXACOV19, NCT04427098 Phase 2 Clinical Recruiting 13 5 Months 300 Andrea Romagnoli, MD, Antonella Castagna, MD, Aria Patacca, MD, Arturo Montineri, MD, Elena Giovanna Bignami, MD, Elvira Grandone, MD, Evelina Tacconelli, MD, Francesco Cristini, MD, Fulvia Mazzaferri, MD, Giovanni Di Perri, MD, Giulio De Stefano, MD, Maddalena Giannella, MD, Marco Baciarello, MD, Marco Mangiafico, MD, Massimo Salvetti, MD, Pierluigi Viale, MD, Raffaello Bellosta, MD, Renzo Rossini, MD, Salvatore Casari, Sophie Testa, MD, Stefano Bonorq, MD, Stefano Triscornia, BS 2020-06-18
COVID-19GAOM: RT-PCR SARS-CoV-2 at 1 Month of COVID-19 Infection in the Geriatric Population Coronavirus disease 19 infection RT-PCR SARS-CoV-2 test alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg France 2020-05-07 2020-08-31 7838, COVID-19GAOM, NCT04427358 Phase Not Applicable Recruiting 1 3 Months 100 Maxence MEYER, MD, Saïd CHAYER, PhD, HDR 2020-06-15
STORM: The Natural History of Hospitalized COVID-19 Patients Coronavirus disease 19 infection, Inflammatory disease, Lung infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-02-23 2020-12-31 NCT04424992, STORM, STORM Phase Not Applicable No longer recruiting 1 10 Months 1433 2020-06-15
Accelerated LFR for Bipolar Patients During the COVID-19 Pandemic Bipolar I disorder, Bipolar II disorder, Coronavirus disease 19 infection Accelerated low-frequency right-sided stimulation protocol alone, B70 Fluid-Cooled Coil alone, MagPro X100 Stimulator alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre for Addiction and Mental Health Canada 2020-06-09 2022-12-31 071-2020, NCT04427137 Phase Not Applicable Recruiting 1 30 Months 50 Daniel Blumberger, MD, Dov Millstone, Hannah Taalman 2020-06-16
Utility of Lactoferrin as a Preventive Agent for Healthcare Workers Exposed to COVID-19 Coronavirus disease 19 infection lactoferrin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Cairo University Egypt 2020-07-31 2020-11-30 CUKA-002, NCT04427865 Phase 2/Phase 3 Clinical Not yet recruiting 1 4 Months 200 Gamal Esmat 2020-06-18
Core Warming of COVID-19 Patients Coronavirus disease 19 infection core warming alone, ensoETM device alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University in St Louis US 2020-06-30 2020-11-30 202005150, NCT04426344 Phase Not Applicable Not yet recruiting 1 5 Months 20 Anne Drewry, MD, Katie Dalton 2020-06-15
ILIAD-7-US-O: InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic patients With COVID-19 Infection Coronavirus disease 19 infection, Lymphocytopenia, Respiratory failure CYT-107 alone IL-7 receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Revimmune Inc Amarex Clinical Research, Memorial Sloan-Kettering Cancer Center US 2020-06-22 2020-12-31 ILIAD-7 COVID US ONCO, ILIAD-7-US-O, NCT04426201 Phase 2 Clinical Not yet recruiting 1 6 Months 48 Frederique Berbille, MHSc, Marcel van den Brink, MD, PhD, Michel MORRE, DVM, Steve Pastores, MD 2020-06-15
CRI-CP: Effectiveness and Safety of Convalescent Plasma in Patients With High-risk COVID-19 Coronavirus disease 19 infection, Multiple organ failure, Respiratory disease, Respiratory failure, Septic shock, Viral pneumonia convalescent plasma alone, standard care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion Santa Fe De Bogota Colombia 2020-07-31 2021-02-28 CRI-CP, NCT04425837, PLASMA COVID-19 Phase 2/Phase 3 Clinical Not yet recruiting 1 7 Months 236 Guillermo E Quintero, Hematologist, Guillermo Enrique Quintero-Vega, José A De la Hoz, Epidemiologist, José De la Hoz, Epidemiologist 2020-06-15
Effect of Covid-19 Epidemic on Primary PCI in Patients With STEMI Coronavirus disease 19 infection, Myocardial infarction percutaneous coronary intervention (PCI) alone Beijing Friendship Hospital China 2019-01-24 2021-07-24 BFH-COVID-19 AND PRIMARY PCI, NCT04427735 Phase Not Applicable Recruiting 1 30 Months 200 Hongwei Li, Hongwei Li, MD, Hongwei Li, doctor, Xuhe Gong 2020-06-15
Ivermectin In Treatment of COVID-19 Patients Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ministry of Health and Population Egypt 2020-06-09 2020-09-01 14-2020/3, NCT04425707 Phase 2 Clinical Recruiting 1 2 Months 100 ehab ah kamal, MD, houssam ho masoud, MD, noha mo asem, MD 2020-06-15
COVEMUZ: SARS-COV-2 Seroprevalence and Seroconversion Among Employees of the Universitair Ziekenhuis Brussel During the 2020 COVID-19 Outbreak Coronavirus disease 19 infection blood sampling alone, questionnaire alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitair Ziekenhuis Brussel Belgium 2020-05-12 2021-05-12 COVEMUZ, COVEMUZ, NCT04426292 Phase Not Applicable Recruiting 1 12 Months 3500 Laurien De Greef, Nurse, Sabine Allard, MD 2020-06-15
HOT-COVID: Handling Oxygenation Targets in COVID-19 Coronavirus disease 19 infection, Hypoxia, Respiratory failure oxygen alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Aalborg Universitetshospital Copenhagen Trial Unit, Rigshospitalet, Denmark Denmark 2020-08-01 2024-03-01 2017-000632-34, AAUH-ICU-03, HOT-COVID, NCT04425031 Phase 4 Clinical Not yet recruiting 1 43 Months 780 Bodil Steen Rasmussen, MD, PhD, Olav Lilleholt Schjørring, MD, PhD, Thomas Lass Klitgaard, MD 2020-06-17
CORONEVRAXE: Study of the Sars-Cov2 Neuroinvasiveness - COVID-19 Coronavirus disease 19 infection, Neurological disease cerebrospinal fluid sampling alone, meningeal and brain parenchyma biopsies alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fondation Ophtalmologique Adolf De Rothschild France 2020-06-30 2022-06-30 CORONEVRAXE, NCT04427254, PBN_2020_16 Phase Not Applicable Not yet recruiting 1 24 Months 500 Amélie YAVCHITZ, MD, Pierre BOURDILLON, MD 2020-06-15
PLACO-COVID: Standard or Convalescent Plasma in Patients With Recent Onset of COVID-19 Respiratory Failure Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure COVID-19 convalescent plasma alone, standard plasma alone, standard therapy protocol alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Ospedaliera Citta della Salute e della Scienza di Torino Italy 2020-06-15 2021-12-15 CS3/33, NCT04428021, PLACO-COVID Phase 2 Clinical Not yet recruiting 1 18 Months 180 Paola Maria Manzini 2020-06-15
CORhum: Morbimortality of Covid-19 in Patients With Chronic Inflammatory Rheumatism Treated With Immunosuppressants Coronavirus disease 19 infection, Rheumatoid arthritis, Spondylarthritis, Systemic lupus erythematosus questionnaire assesment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Regional Universitaire de Lille France 2020-08-31 2020-12-31 2020-A01650-39, CORhum, EQ2020_04, NCT04426279 Phase Not Applicable Not yet recruiting 1 4 Months 1500 Jean-Guillaume Letarouilly, MD 2020-06-15
MK-5475 in Participants With Hypoxemia Due to COVID-19 Pneumonia Coronavirus disease 19 infection, Hypoxia, Viral pneumonia MK-5475 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Merck Sharp & Dohme Corp 2020-07-07 2020-11-10 2020-002062-14, 5475-009, MK-5475-009, NCT04425733 Phase 1 Clinical Not yet recruiting 0 4 Months 64 Medical Director 2020-06-15
CRISIS: Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Patients With COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome brequinar alone, standard of care alone Dehydrogenase inhibitor, Dihydroorotate dehydrogenase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clear Creek Bio, Inc US 2020-06-12 2020-10-31 CCB-CRISIS-01, CRISIS, NCT04425252 Phase 1/Phase 2 Clinical Not yet recruiting 3 4 Months 24 Barbara L Powers, Ph.D, Gerard J Criner, MD, James S Pope, MD, Karel Calero, MD, Samuel Pope, MD 2020-06-17
CARDS: Cancer: Rapid Diagnostics and Immune Assessment for SARS-CoV-2 (COVID-19) Advanced solid tumor, Coronavirus disease 19 infection, Lymphoma antigen lateral flow assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The Royal Marsden NHS Trust Mologic Ltd, NIHR Biomedical Research Centre, Oxford, St Georges University of London, The Royal Marsden Cancer Charity UK 2020-05-26 2021-04-30 20/NE/0139, CARDS, CCR 5287, NCT04427280 Phase Not Applicable Recruiting 1 11 Months 60 David Lau, MBBS FRACP, Shannon Kidd, Sheela Rao, MD FRCP, Sue Cromarty 2020-06-15
A multicenter, randomized, double-blind, parallel-arm, placebo-controlled, phase II/III clinical study to assess opaganib in patients hospitalized with severe SARS-CoV-2 infection and pneumonia Coronavirus disease 19 infection, Viral pneumonia opaganib alone, standard-of-care alone Dihydroceramide delta 4 desaturase inhibitor, Sphingosine kinase 2 inhibitor RedHill Biopharma Ltd Europe, Russian Federation Phase 2/Phase 3 Clinical Planned 1 270 2020-06-12
A Phase II Trial of Infliximab in Coronavirus Disease 2019 (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Variable regimens including Tylenol , diphenhydramine , infliximab , infliximab biosimilar, Samsung Bioepis/ Merck & Co , prednisone TNF alpha ligand inhibitor, TNF binding agent Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tufts Medical Center National Institutes of Health US 2020-06-01 2020-12-31 NCT04425538, STUDY00000564 Phase 2 Clinical Recruiting 1 7 Months 17 Christian Lawlor, Jaime Chisholm, Paul Mathew, MD 2020-06-15
Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult Patients With COVID-19 Coronavirus disease 19 infection REGN-CoV2 alone COVID19 Spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Regeneron Pharmaceuticals Inc US 2020-06-09 2020-11-21 NCT04425629, R10933-10987-COV-2067 Phase 1/Phase 2 Clinical Recruiting 1 5 Months 1054 Clinical Trial Management, Clinical Trials Administrator 2020-06-17
A randomized, placebo-controlled, phase III clinical trial to assess losmapimod the treatment of patients with COVID-19 Coronavirus disease 19 infection losmapimod alone Double homeobox protein 4 inhibitor, p38 MAP kinase alpha inhibitor, p38 MAP kinase beta inhibitor, p38 MAP kinase inhibitor Fulcrum Therapeutics Inc US Phase 3 Clinical Planned 1 2020-06-12
A study to evaluate the clinical characteristics and epidemiological trend of COVID-19 infected children with or without GI symptoms Coronavirus disease 19 infection The University of Hong Kong Wuhan medical care center for women and children Hong Kong Phase Not Applicable Status not specified 1 244 Dr Kenneth Wong Kak-yuen 2020-06-12
MRCS: 'Minority and Rural Health Coronavirus Study (MRCS)' to evaluate the impact of COVID-19 on racial minorities and underserved communities across the country Coronavirus disease 19 infection Centene Corp, National Minority Quality Forum (NMQF), Quest Diagnostics Inc US 2020-06-30 MRCS Phase Not Applicable Not yet recruiting 1 5000 Alan Morgan, Elizabeth Ofili, Gary Puckrein, Gloria Wilder, Latrice Landry, Richard Beswick, Salaheddin Mahmud, Suja M. Mathew, Thomas LaVeist, Vin Gupta, William A. Meyer 2020-06-12
DOD: A Multicenter, Randomized-Controlled trial to Assess the Safety and Efficacy of Seraph 100 Microbind Affinity Blood Filter (Seraph 100) in the treatment of critically-ill COVID-19 patients Coronavirus disease 19 infection Seraph 100 Microbind Affinity Blood Filter alone ExThera Medical LLC US Department of Defense Europe, US DOD Phase Not Applicable Planned 2 2020-06-11
An multi-national multicenter clinical trial of YS-SC2-010 for the treatment of Coronavirus disease 19 infection Coronavirus disease 19 infection YS-SC2-010 alone Yisheng Biopharma Co Ltd US, Europe, China, South East Asia Phase Not Applicable Planned 2 2020-06-11
A clinical study to evaluate the safety and tolerability of TY-027 for the treatment of COVID-19 Coronavirus disease 19 infection TY-027, Tychan alone Healthy volunteers accepted Tychan Pte Ltd Phase 1 Clinical Recruiting 0 23 2020-06-15
A clinical proof-of-concept study to assess SARS-CoV-2-specific virus-neutralizing antibodies for the potential treatment of COVID-19 Coronavirus disease 19 infection SARS-CoV-2-neutralizing monoclonal antibodies (COVID-19), Memo Therapeutics alone Memo Therapeutics AG 2020-12-31 Phase Not Applicable Planned 0 2020-06-11
An observation study to assess the effect of favipiravir in hospitalized patients with COVID-19 Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Fujita Health University Japan Phase Not Applicable Status not specified 1 2020-06-11
A clinical study of anti-SARS-CoV-2 spike glycoprrotein monoclonal antibody (COVID-19), Celletrion for the treatment of COVID-19 Coronavirus disease 19 infection S-protein modulator (COVID-19), Celletrion alone Moesin modulator Celltrion Healthcare Co Ltd 2020-07-31 Phase Not Applicable Planned 0 2020-06-15
PI-Covid-19: Primary Prevention of Infection by COVID-19 in Health Providers Coronavirus disease 19 infection immunostimulant therapy alone, Variable regimens including allicin , eugenol , quercetin Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Unidad de Investigación Genética Molecular Universidad de Antioquia Colombia 2020-07-31 2020-09-30 NCT04420260, PI-Covid-19, UNIGEM PT-IC-02 Phase 2 Clinical Not yet recruiting 1 2 Months 300 Beatriz H Aristizabal, PhD, Clara I Aristizabal, CEO, Clara Ines Aristizaba 2020-06-11
A trial to assess LVRNA-009 for COVID-19 vaccine Coronavirus disease 19 infection LVRNA-009 alone COVID19 Spike glycoprotein modulator Zhuhai Lifanda Biotechnology Co Ltd Phase Not Applicable Planned 0 2020-06-11
COVID-19-Related Health and Infection Control Practices Among Dentists Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) American Dental Association Foundation US 2020-06-08 2021-06-08 20-08, NCT04423770 Phase Not Applicable Recruiting 1 12 Months 4000 Cameron G Estrich, MPH, PhD, Marcelo Araujo, DDS, MS, PhD 2020-06-12
QuadraMune for Prevention of COVID-19 Coronavirus disease 19 infection QuadraMune alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Therapeutic Solutions International Inc US 2020-06-08 2020-11-08 NCT04421391, QUADRAMUNE002 Phase 2 Clinical Recruiting 1 5 Months 500 James Veltmeyer, MD, Thomas E Ichim, Thomas E Ichim, Ph.D 2020-06-11
BISCUIT: Bromhexine And Spironolactone For Coronаvirus Infection Requiring Hospitalization Coronavirus disease 19 infection, Viral pneumonia bromhexine plus spironolactone Aldosterone antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) MV Lomonosov Moscow State University Russian Federation 2020-05-16 2020-08-23 BISCUIT, MSU160520, NCT04424134 Phase 3 Clinical Recruiting 1 3 Months 80 Julia Begrambekova, Julia Begrambekova, Phd, Yana Orlova, Professor 2020-06-11
Needs of Persons With Spinal Cord Injury (SCI) Coronavirus disease 19 infection, Spinal cord injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US US 2020-05-22 2020-12-31 202005026, NCT04422769 Phase Not Applicable Recruiting 1 7 Months 250 Kerri A Morgan, PhD, Kimberly A Walker, OTD 2020-06-11
A clinical study to assess COVID-19 mRNA vaccine in the treatment of subjects with COVID-19 Coronavirus disease 19 infection mRNA vaccine (LPP delivery platform, COVID-19), Shanghai Yinuosi Biotechnology/Tongji University/Biocad/Stemrina Therapeutics alone Stemirna Therapeutics Co Ltd GenScript Biotech Corp China Phase Not Applicable Planned 1 2020-06-11
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity During the COVID19 Pandemic Coronavirus disease 19 infection, Infectious disease, Mitochondrial disease Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Human Genome Research Institute National Institutes of Health Clinical Center US 2020-06-24 2025-05-01 20-HG-N120, 200120, 999920120, NCT04419870 Phase Not Applicable Recruiting 2 58 Months 200 Eliza M Gordon-Lipkin, M.D., Shannon Kruk, R.N. 2020-06-19
SANCO: A Saudi Arabia based study into the impact of coronavirus infection on the nervous system Ataxia, Cerebrovascular disease, Coronavirus disease 19 infection, Muscle injury, Neuropathic pain, Seizure disorder, Taste disorder, Vision disorder RT-PCR alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) King Saud Medical City Saudi Arabia 2020-03-01 2021-02-28 ISRCTN15475176, KSMC, IRB, H1RI-24-MAY20-01, SANCO Phase Not Applicable Recruiting 1 12 Months 1000 Prof Karakitsos 2020-06-17
CAPRI: Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients Coronavirus disease 19 infection ABO compatible anti-SARS-CoV-2 convalescent fresh frozen plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California San Francisco Blood Systems Inc, San Francisco General Hospital US 2020-06-08 2021-04-30 20-30794, CAPRI, NCT04421404 Phase 2 Clinical Recruiting 3 10 Months 30 Annie Leutkemeyer, MD, Brian Graham, MD, Carolyn Hendrickson, MD, Jonathan Esensten, MD, Kelvin Moore, BA, Kelvin Moore, BS, Lisa Winston, MD, Priscilla Hsue, MD, Rachel Bystritsky, MD, Rebecca Park, MA, Rebecca Park, MS, Vivek Jain, MD 2020-06-18
The effects of restricting going out on patients with chronic respiratory disease Coronavirus disease 19 infection, Respiratory disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Asahi Rosai Hospital Japan 2020-06-12 UMIN000040715 Phase Not Applicable Recruiting 1 300 Tomohiro Kawaji 2020-06-15
LOWRAD-Cov19: Low Dose Radiotherapy for COVID-19 Pneumonitis Coronavirus disease 19 infection, Viral pneumonia radiotherapy alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Clinico San Carlos Spain 2020-05-01 2020-09-08 LOWRAD-COV19, LOWRAD-Cov19, NCT04420390 Phase Not Applicable Recruiting 1 4 Months 41 Manuel Gonzalo Vazquez Masedo, MD, PhD, Manuel Gonzalo Vazquez Masedo, MD,PhD, Manuel Gonzalo Vázquez Masedo, MD 2020-06-15
FRENCH ICU: Study of the Increase in ICU Beds Capacity During COVID-19 Pandemic in France Coronavirus disease 19 infection Centre Hospitalier Universitaire de Nimes France 2020-05-06 2020-06-05 30RC20_0117, FRENCH ICU, NCT04420286 Phase Not Applicable Recruiting 1 1 Month 9000 Jean-Yves LEFRANT, Jean-Yves LEFRANT, MD, PhD 2020-06-15
RetroCov: Impact of the Covid-19 Pandemic on Gastrointestinal and Liver Diseases Coronavirus disease 19 infection, Decompensated liver cirrhosis, Gastrointestinal disease, Liver disease antiviral drug therapy alone Medical University of Graz Austria 2020-06-15 2021-12-31 NCT04420637, RETROCOV, RetroCov Phase Not Applicable Not yet recruiting 1 18 Months 1000 Vanessa Stadlbauer, MD 2020-06-14
Study of ivermectin against COVID-19 Coronavirus disease 19 infection ivermectin alone, standard of care therapy alone Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Huvepharma Eood Bulgaria 2020-05-15 2020-002091-12, HUVE-19-CT-001 Phase 2 Clinical Recruiting 1 120 2020-06-13
A Phase III clinical trial of NLP-21 for the treatment of COVID-19 Coronavirus disease 19 infection NLP-21 alone NovaLead Pharma Pvt Ltd India Phase 3 Clinical Not yet recruiting 1 150 2020-06-18
GETAFIX: A study comparing favipiravir versus standard of care management as an early treatment arm in COVID-19 Hospitalized patients Coronavirus disease 19 infection favipiravir alone, supportive care alone RNA polymerase inhibitor Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) NHS Greater Glasgow and Clyde, University of Glasgow UK 2020-05-20 2020-001904-41, GETAFIX, GETAFIX-2020 Phase 2 Clinical Recruiting 1 Liz-Anne Lewsley 2020-06-13
Efficacy and Safety of Nitazoxanide 600 mg, tid for the Treatment of Hospitalized Patients With COVID-19 Coronavirus disease 19 infection, Respiratory failure nitazoxanide (Viranitta) alone, standard of care alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azidus Brasil Farmoquimica SA, Vera Cruz Casa de Saúde Campinas 2020-07-31 2020-08-31 NCT04423861, NITFQM0520OR Phase 2 Clinical Not yet recruiting 0 1 Month 50 Florentino de Araujo Cardoso Filho, MD, PhD, Luciana Ferrara 2020-06-15
Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19 Coronavirus disease 19 infection, Viral pneumonia standard treatment alone, chloroquine plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva Brazil 2020-04-16 2020-08-31 CLOROTRIAL, NCT04420247 Phase 3 Clinical Recruiting 1 4 Months 100 ALVARO REA-NETO, MD, MARCOS VINICIUS O QUEIROGA, MD, Marcos Vinicius O Queiroga, MD, Mirella Cristine Oliveira, MD, RAFAELLA STRADIOTTO BERNADELLI, PHYSIOTHERAPIST 2020-06-19
Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada) Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) McGill University Health Center, Research Institute of the McGill University Health Centre Eastern Health, Lawson Health Research Institute, McMaster University, University of Alberta, University of British Columbia, University of Manitoba, University of Minnesota Canada, US 2020-03-25 2020-08-26 2020-6549, NCT04421664 Phase 3 Clinical Recruiting 8 5 Months 1500 Emily G McDonald, MD MSc, Glen Drobot, MD, Ilan Schwartz, MD, Lauren E Kelly, PhD, Lauren MacKenzie, MD, Matthew P Cheng, MD, Michael Silverman, MD, Peter Daley, MD MSc, Ryan Zarychanski, MD, Sara Belga, MD, Sylvain Lother, MD, Todd C Lee, MD MPH FIDSA, Zain Chagla, MD 2020-06-15
Hydroxychloroquine in comparison with hydroxychloroquine + azithromycin in patients with covid-19 Coronavirus disease 19 infection azithromycin plus hydroxychloroquine Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University Iran 2020-05-19 IR.SBMU.RETECH.REC.1399.069, IRCT20200428047228N2 Phase 3 Clinical No longer recruiting 1 40 Dr. Mohammad Fathi, ِDr.Mohammad Fathi 2020-06-19
Pentaglobin effect in critically ill patients with COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Anticoagulant therapy alone, oxygen therapy alone, pentaglobin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahid Beheshti University of Medical Sciences, Laser Application in Medical Sciences Research Center Iran 2020-06-22 IR.SBMU.NRITLD.REC.1399.014, IRCT20151227025726N18 Phase 2/Phase 3 Clinical Not yet recruiting 1 30 Farzaneh Dastan, Payam Tabarsi 2020-06-12
COPROS study: COVID-19 in professional soccer players Coronavirus disease 19 infection Amphia Hospital Netherlands 2020-05-18 2020-09-01 COPROS study, NL8685, W20.108 Phase Not Applicable Recruiting 1 3 Months 140 Jan Kluytmans 2020-06-15
COVID-19 treatment outcomes at the University Medical Center Freiburg Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Albert-Ludwigs-Universität Freiburg Germany 2020-05-31 DRKS00021775 Phase Not Applicable Recruiting 1 400 Mr. Prof. Dr. Siegbert Rieg 2020-06-12
TMD: Targeted Melanoma Detection With Skin Self-Examination During COVID-19 Restricted Physician Access Coronavirus disease 19 infection, Melanoma Home sample collection of concerning mole with physician supervision alone, SSE educational intervention alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Northwestern University US 2020-06-15 2021-12-30 COVID_IMPACT, NCT04420273, STU00212165, TMD Phase Not Applicable Not yet recruiting 1 18 Months 1000 Dalya A Durst, June K Robinson, MD 2020-06-15
Maintenance Versus Reduction of Immunosuppression for Renal Transplant Patients Hospitalized With COVID-19 Disease Coronavirus disease 19 infection, Kidney transplantation Maintenance of immunosuppression alone, azathioprine alone, mycophenolate mofetil alone Inosine monophosphate dehydrogenase inhibitor, PurH purine biosynthesis protein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Brigham & Women's Hospital US 2020-07-01 2021-12-31 2020P001516, NCT04420364 Phase 2/Phase 3 Clinical Not yet recruiting 1 18 Months 50 Finnian R Mc Causland, MBBCh, MMSc, Jamil Azzi, MD, PhD 2020-06-15
Telematic Monitoring Through a Mobile Application of Patients With COVID-19 Coronavirus disease 19 infection Farmalarm alone, SMART PULSE OXIMETER OL-750 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Vall D'Hebron Spain 2020-03-31 2020-05-18 NCT04423289, PR(AG)182-2020 Phase Not Applicable Completed 1 1 Month 150 Oscar Len, MD, PhD 2020-06-12
External Dead Space in Ventilated Covid-19 Patients Coronavirus disease 19 infection apparatus dead space alone, mechanical ventilation alone, volumetric capnography alone Karolinska Institutet Stockholm County Council Sweden 2020-06-07 2020-09-07 KAROLINSKA, NCT04424082 Phase Not Applicable Recruiting 1 3 Months 40 Björn Persson, MD PhD, Jacob Karlsson, MD PhD, Per-Arne Lönnqvist, Prof 2020-06-15
BREATH: Baricitinib for corona Virus pneumonia (COVID-19): a Therapeutic Trial Coronavirus disease 19 infection, Pneumonia baricitinib alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) IRCCS Policlinico San Matteo Italy 2020-05-15 2020-11-15 2020-001185-11, BREATH, NCT04399798 Phase 2 Clinical Not yet recruiting 1 6 Months 13 Carlomaurizio Montecucco, Prof, Raffaele Bruno, Prof, Sara Monti, MD, Valentina Zuccaro, MD 2020-06-12
COVID-19 Virtual Care at Home Coronavirus disease 19 infection VIRTUES platform alone, Virtual Care at Home alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lawson Health Research Institute Cardiac Arrhythmia Network of Canada Canada 2020-06-08 2021-12-31 CTO 3210, NCT04420182 Phase Not Applicable Not yet recruiting 1 18 Months 2000 Anthony Tang, MD, Marko Mrkobrada, MD, Sabrina Wall 2020-06-12
Co-STAR: Coronavirus Smell Therapy for Anosmia Recovery Coronavirus disease 19 infection, Dysomia budesonide alone, high-concentration essential oil olfactory training alone, low-concentration essential oil olfactory training alone, nasal saline lavage alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US US 2021-06-01 2023-12-31 Co-STAR, NCT04422275, PA-18-334 Phase 2 Clinical Not yet recruiting 1 31 Months 200 Jay F. Piccirillo, MD 2020-06-13
A prospective, interventional, single-active-arm, single-center pilot trial of mavrilimumab for the treatment of patients with severe pneumonia and hyperinflammation associated with COVID-19 Coronavirus disease 19 infection, Inflammatory disease, Respiratory distress syndrome, Viral pneumonia mavrilimumab alone, standard of care therapy alone C-reactive protein inhibitor, Chemokine CC22 ligand inhibitor, GM-CSF receptor antagonist, Hemoglobin scavenger receptor antagonist, Metalloprotease-1 inhibitor, Metalloprotease-3 inhibitor, Small inducible cytokine A17 ligand inhibitor, VEGF gene inhibitor Kiniksa Pharmaceuticals Ltd Italy Phase Not Applicable Status not specified 1 13 Lorenzo Dagna 2020-06-15
A global, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of mavrilimumab in addition to standard of care therapy in the treatment of patients with severe COVID-19 pneumonia and hyperinflammation Coronavirus disease 19 infection, Lung inflammation, Viral pneumonia mavrilimumab alone, standard of care therapy alone C-reactive protein inhibitor, Chemokine CC22 ligand inhibitor, GM-CSF receptor antagonist, Hemoglobin scavenger receptor antagonist, Metalloprotease-1 inhibitor, Metalloprotease-3 inhibitor, Small inducible cytokine A17 ligand inhibitor, VEGF gene inhibitor Kiniksa Pharmaceuticals Ltd Phase 2/Phase 3 Clinical Planned 0 580 2020-06-14
A clinical trial to assess the safety and effectivness of Russian Coronavirus Vaccine in healthy volunteers Coronavirus disease 19 infection anti-coronavirus vaccine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Ministry of Defence of the Russian Federation Russian Federation Phase Not Applicable Recruiting 1 50 2020-06-11
PULCO-19: Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia Coronavirus disease 19 infection, Lung injury, Viral pneumonia pulmonary anomaly test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-05-28 2022-05-31 NCT04422613, PULCO-19, RC31/20/0181 Phase Not Applicable Recruiting 1 24 Months 60 Elise Noël-Savina, MD 2020-06-15
Clinical Trial on the Efficacy and Safety of Bemiparin in Patients Hospitalized Because of COVID-19 Coronavirus disease 19 infection bemiparin alone Factor Xa antagonist, Heparin agonist, Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HM Research Foundation Hospitals Syntax for Science Spain 2020-06-04 2021-03-31 2020-001548-24, BEMICOVID-19, NCT04420299 Phase 2 Clinical Recruiting 2 9 Months 120 Antonio Cubillo, MD, Elena Nuñez Cuerda, MD, José Felipe Varona, MD 2020-06-12
Impact of Burnout on Cardiovascular and Immune Biomarkers in Healthcare Professionals - Covid-19 Pandemic in Abu Dhabi Cardiovascular disease, Coronavirus disease 19 infection, Immune disorder, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Khalifa University Of Science & Technology & Research (Kustar) Abu Dhabi University, AE, Cleveland Clinic Abu Dhabi, Mediclinic Middle East, Sheikh Khalifa Medical City, Sheikh Shakhbout Medical City, Zayed Military Hospital United Arab Emirates 2020-06-14 2020-12-31 CPRA-2020-034, NCT04422418 Phase Not Applicable Recruiting 4 6 Months 200 Ahmad Mounir, MD, Hashel Al Tunaiji, MD MSc, Nadya Matroushi, MD, Ovidiu C Baltatu, MD PhD, Seema El Khider Nour, MD, Wael Almahmeed, MD 2020-06-15
C3PI: Murdock Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study Coronavirus disease 19 infection biological sampling alone, polymerase chain reaction alone, serological testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Duke University North Carolina Department of Health and Human Services US 2020-06-15 2021-06-30 C3PI, NCT04424004, PRO00105703 Phase Not Applicable Not yet recruiting 1 12 Months 500 Abha Singh, Carla Kingsburg, Kristin Newby, MD 2020-06-12
The Impact of COVID-19 on Dialysis Users Coronavirus disease 19 infection, End stage renal disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Portsmouth Portsmouth Hospitals, University of Reading UK 2020-06-03 2020-09-03 004, NCT04422873 Phase Not Applicable No longer recruiting 1 3 Months 40 Dr Zoe Saynor, Senior Lecturer 2020-06-11
Utility of Lactoferrin as an Adjunct Therapeutic Agent for COVID-19 Coronavirus disease 19 infection Standard of care alone, lactoferrin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Cairo University Egypt 2020-06-30 2020-11-30 CUKA-001, NCT04421534 Phase 2/Phase 3 Clinical Not yet recruiting 1 5 Months 150 Gamal Esmat 2020-06-11
ACES: Angiotensin II Infusion in COVID-19-Associated Vasodilatory Shock: A multinational, multicenter registry Cardiogenic shock, Coronavirus disease 19 infection Angiotensin II alone, novel therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Austin Health Australian and New Zealand Intensive Care Research Centre, Monash University Australia, UK, Belgium, Canada, Italy, Germany 2020-06-15 2020-12-30 ACES, ACTRN12620000620921 Phase Not Applicable Not yet recruiting 9 6 Months 315 Dr Ary Serpa Neto, Mr Tony Trapani, Prof Rinaldo Bellomo 2020-06-12
BEAT: Open label, prospective study for the Biofourmis Everion armband telemonitoring solution for patients during COVID-19 home isolation within South Western Sydney Coronavirus disease 19 infection Everion armband alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) South Western Sydney Local Health Network Ingham Institute for Applied Medical Research Australia 2020-06-05 2020-09-30 ACTRN12620000635965, BEAT Phase Not Applicable Not yet recruiting 6 3 Months 50 Prof Josephine Chow 2020-06-12
Analysis of the Inflammatory Response and the Development of Humoral and Cellular Immunity in Patients With COVID-19 Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Coordinacion de Investigacion en Salud Instituto Mexicano del Seguro Social Mexico 2020-04-15 2020-08-15 NCT04423640, R-2020, 3601-043 Phase Not Applicable Recruiting 1 4 Months 200 Constantino López Macías, PhD, Eduardo Ferat-Osorio, PhD, Suria Loza Jalil, MD 2020-06-12
A potential use of VAL-201 in a combination treatment for patients suffering a hyperimmune response to Coronavirus SARS-CoV2 infection Coronavirus disease 19 infection VAL-201 + undisclosed compounds (COVID-19), Oncolytika/ Black Cat Bio alone Src tyrosine kinase inhibitor Black Cat Bio Limited, Oncolytika Limited ValiRx plc Phase Not Applicable Planned 0 2020-06-19
Knowledge, practices, and risk and susceptibility perceptions on exposure to COVID-19: A qualitative triangulation study on pregnant women, their spouses, and non-pregnant reproductive-aged women with healthcare workers in Metro Manila Coronavirus disease 19 infection Philippine General Hospital Philippines 2020-05-26 2021-05-26 PHRR200604-002695 Phase Not Applicable Not yet recruiting 1 12 Months Erlidia F. Llamas-Clark, MD, MPH, PhD, Maria Stephanie Fay S. Cagayan, Maria Stephanie Fay S. Cagayan, MD 2020-06-11
SeniorCOVIDRea: Senior-COVID-Rea Multicentric Survey Coronavirus disease 19 infection blood sampling alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospices Civils De Lyon France 2020-04-01 2020-08-15 69HCL20-0386, NCT04422340, SeniorCOVIDRea Phase Not Applicable Recruiting 5 4 Months 185 Claire Falandry, MD, Max Haine, MD, Vincent COLLANGE, MD 2020-06-17
EPRICOD: Evaluation of the COVID-19 Infection Response in Patients Admitted to the Emergency Department for Dyspnea Coronavirus disease 19 infection, Dyspnea Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-03-13 2021-06-30 EPRICOD, NCT04422587, RC31/20/0149 Phase Not Applicable No longer recruiting 1 15 Months 1860 Paul-Henri Auboiroux, MD 2020-06-10
PANDEMIC: Mental Health and Academic Performance in COVID-19 Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Mexicano del Seguro Social Mexico 2020-04-01 2020-07-30 MENTAL01, NCT04420416, PANDEMIC Phase Not Applicable Recruiting 1 3 Months 720 Alejandro Gonzalez Ojeda, PhD, Gonzalez Ojeda Alejandro 2020-06-10
ALTRISCOVID-19: Analysis of Long-Term Risk of Coronavirus Disease-19 Emergency Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto Neurologico Mediterraneo NEUROMED Italy 2020-06-08 2021-12-31 ALTRISCOVID-19, DEP 1/2020, NCT04422262 Phase Not Applicable Not yet recruiting 1 18 Months 10000 Licia Iacoviello, Licia Iacoviello, MD, PhD, Marialaura Bonaccio 2020-06-11
Tocilizumab in COVID-19 Positive Patients Coronavirus disease 19 infection, Inflammatory disease standard of care alone, tocilizumab (intravenous), Roche/Chugai alone IL-6 receptor antagonist, IL-6 receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Calgary Roche Holding AG Canada 2020-06-30 2021-06-30 NCT04423042, REB20-0713 Phase 3 Clinical Not yet recruiting 1 12 Months 30 Jacinda R Larson, PhD, Namneet Sandhu, MPH, Susanne Benseler, MD PhD 2020-06-11
SeroCOVIDial: Assessment of COVID-19 Seroconversion in Patients on Chronic Hemodialysis and in Their Caregivers, a Cohort Study Coronavirus disease 19 infection Biosynex serological test alone, seroconversion assay alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux De Marseille France 2020-06-05 2020-12-15 2020-34, 2020-A01515-34, NCT04420338, SeroCOVIDial Phase Not Applicable Recruiting 1 6 Months 800 Jean-Olivier ARBAUD, Director, Noémie JOURDE-CHICHE, PU-PH, Philippe BRUNET, PU-PH 2020-06-18
CYTOAID: Data Analysis of the Cytokine Adsorption Treatment on Coronavirus Disease-19 (COVID-19) Patients With Respiratory Failure Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure CytoSorb alone, cytokine adsorption therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Of Pécs 2020-07-01 2022-12-01 20802-5/2020/EUIG, CYTOAID, NCT04422626 Phase Not Applicable Not yet recruiting 0 29 Months 42 Péter Hegyi, MD, PhD, DSc, Péter Hegyi, MD, PhD, Dsc, Zsolt Molnár, MD, PhD, Dsc 2020-06-13
SEROPHUGAC: Serological Study of the Exposure of Personnel to Sars-cov-2 Coronavirus disease 19 infection RT-PCR alone, serology test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Centre Hospitalier Saint Joseph Saint Luc de Lyon 2020-06-08 2020-06-30 NCT04422977, SEROPHUGAC, SEROPHUGAC Phase Not Applicable Not yet recruiting 0 900 2020-06-11
SARS-CoV-2 PoC/ELISA: Evaluation of three commercially available rapid assays for detection of IgG and/or IGM antibodies to SARS-CoV-2 (COVID-19) for assessment of contact persons’ immune status and termination of quarantine and self-isolation – a prospective pilot study Coronavirus disease 19 infection COVID-19 antibody point-of-care test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Landesklinikum Neunkirchen Austria 2020-05-20 DRKS00022083, GS1-EK-3/168-2020, SARS-CoV-2 PoC/ELISA Phase Not Applicable Recruiting 1 70 Klaus Hackner 2020-06-11
SynCov: Synbiotic Therapy of Gastrointestinal Symptoms During COVID-19 Infection Coronavirus disease 19 infection, Diarrhea, Enteritis, Gastrointestinal disease Omnibiotic AAD alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical University of Graz Austria 2020-08-31 2022-12-31 NCT04420676, SYNCOV, SynCov Phase Not Applicable Not yet recruiting 1 28 Months 108 2020-06-11
COVID-EP: Cohort Comparing the Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms Coronavirus disease 19 infection, Lung embolism, Respiratory disease, Respiratory distress syndrome, Viral pneumonia CT pulmonary angiogram alone, computed tomography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Groupe Hospitalier Paris Saint-Joseph France 2020-03-01 2020-04-20 COVID-EP, COVID-EP, MR 4516150520, NCT04420312 Phase Not Applicable Completed 1 1 Month 1024 2020-06-11
Prophylactic Ivermectin in COVID-19 Contacts Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Zagazig University Egypt 2020-05-31 2020-07-31 NCT04422561, ZU-IRB-6150L31-5-2020 Phase 2/Phase 3 Clinical Recruiting 1 2 Months 100 Waheed Shouman, Waheed Shouman, MD 2020-06-11
PICS-COVID19: Post Intensive Care Syndrome in COVID-19 Patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Corporacion Parc Tauli Spain 2020-06-01 2022-06-01 2020/577, NCT04422444, PICS-COVID19 Phase Not Applicable Recruiting 1 24 Months 100 SOL FERNANDEZ, PhD, Sol Fernandez-Gonzalo, Sol Fernandez-Gonzalo, PhD 2020-06-13
IDENTIFY: Identification of a Responsive Subpopulation to Hydroxychloroquine in COVID-19 Patients Using Machine Learning Coronavirus disease 19 infection COViage alone Dascena US 2020-03-10 2020-06-04 060820, IDENTIFY, NCT04423991 Phase 2 Clinical Completed 1 2 Months 290 2020-06-12
Sero-prevalence of Coronavirus Disease 2019 (COVID-19) in Healthcare Workers Coronavirus disease 19 infection Ortho clinical diagnostics chemiluminescent technique alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Cairo University, Egyptian Center for Research and Regenerative Medicine Academy of Scientific Research and Technology, National Research Center Patent Office Egypt 2020-06-16 2020-09-30 COVID-19\004, NCT04424017 Phase Not Applicable Not yet recruiting 1 3 Months 726 Khaled Eissa Amer, MD 2020-06-12
Knowledge About Covid-19 Infection Coronavirus disease 19 infection counseling alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs) Aljazeera Hospital Egypt 2020-04-01 2020-06-20 KNOWLEDGE ABOUT COVID 19, NCT04423692 Phase Not Applicable Recruiting 1 2 Months 300 Mahmoud Alalfy, Mahmoud Alalfy, PhD 2020-06-10
QT-COVID-19: Effects on the Qt Interval of COVID-19 Coronavirus Infection Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital General Universitario Gregorio Marañon Spain 2020-05-29 2020-12-01 NCT04422535, QT-COVID-19, QT-COVID-19 Phase Not Applicable Recruiting 1 6 Months 80 Javier Hortal, MD PhD, Matilde Zaballos, Matilde Zaballos, MD, PhD, Matilde Zaballos, MDPhD 2020-06-12
CHRONOS19: Observational, Prospective, Cohort Study: Registry of Patients With Hematological Disease and COVID-19 in Russia Coronavirus disease 19 infection, Hematological disease, Hematological neoplasm Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hematology Research Center Russian Federation 2020-06-08 2021-07-08 CHRONOS19, CHRONOS19, NCT04422470 Phase Not Applicable Not yet recruiting 1 13 Months 200 Olga Gavrilina, PhD 2020-06-15
ICOLS: Implications of Covid-19 on the Lifestyle Changes Coronavirus disease 19 infection online survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Unita Sanitaria Locale di Reggio Emilia Italy 2020-05-04 2020-06-15 ICOLS, ICOLS_COVIDSTYLE, NCT04423978 Phase Not Applicable Recruiting 1 1 Month 1500 Elisa Mazzini, MD 2020-06-15
A phase II clinical trial to evaluate the efficacy of JS-016 in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection JS-016 alone COVID19 Spike glycoprotein inhibitor Eli Lilly & Co, Shanghai Junshi Biosciences Co Ltd Phase 2 Clinical Planned 0 2020-06-10
COVID-19 and Liver Injury in Patients With or Without Underlying Liver Disease: A Multicenter, Retrospective-prospective, Observational Study Coronavirus disease 19 infection, Liver disease, Liver failure, Liver injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Max Healthcare Institute Ltd, India, Max Super Speciality Hospital India 2020-06-07 2020-08-30 COVID 19/LI/2020, CTRI/2020/06/025802, NCT04422379 Phase Not Applicable Not yet recruiting 1 2 Months 314 Dr Saroj Kumar Sbath, Dr Vivek Raj, Kaushal Madan, DM, Rajesh Saxena, Vivek Raj, DM 2020-06-19
PneumoSeroCov: COVID-19 Serology in Pulmonologists Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-05-01 2020-05-30 NCT04422574, PneumoSeroCov, RECHMPL20_0343 Phase Not Applicable Completed 1 97 Arnaud Bourdin, MD PhD 2020-06-15
The Safety and Efficacy of Imatinib for the Treatment of SARS-COV-2 Induced Pneumonia Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Respiratory failure, Viral pneumonia imatinib alone, standard treatment alone Abl tyrosine kinase inhibitor, Bcr protein inhibitor, Kit tyrosine kinase inhibitor, PDGF receptor antagonist, Signal transduction inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Alexandria Science, Technology and Innovation Funding Authority (STIFA) Egypt 2020-06-30 2020-10-31 ALEX CCM 2020/5, NCT04422678 Phase 3 Clinical Not yet recruiting 1 4 Months 30 ASSAAD, MD, PhD, Hany ASSAAD, MD, PhD 2020-06-12
Endoscopic Interventions in Patients With COVID-19 Coronavirus disease 19 infection endoscopic intervention alone University Hospital Tubingen Germany 2020-03-01 2020-05-15 242/2020BO2, NCT04423003 Phase Not Applicable Completed 1 2 Months 10 2020-06-11
Thrombosis Risk Assessment and Clinical Presentation of Covid-19 Pneumonia Coronavirus disease 19 infection, Thrombosis, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nisantasi University Turkey 2020-06-30 2020-07-31 20200504443, NCT04423315 Phase Not Applicable Not yet recruiting 1 1 Month 70 Hasan Haciosman, M.D., Murat Civan, M.D. 2020-06-12
Investigational COVID-19 Convalescent Plasma Infusion for Severely or Life-threateningly Ill COVID-19 Patients Coronavirus disease 19 infection, Multiple organ failure, Respiratory failure, Septic shock COVID-19 convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rutgers University University Hospital, Newark, New Jersey US NCT04420988, PRO2020000746, PRO2020000911 Phase Not Applicable Recruiting 2 Khyati Mehta, MPH, Marc Klapholz, MD, MBA 2020-06-15
COVIDUS-NOR: Ultrasonography in Norwegian Emergency Department Patients With Suspected Covid-19 Infection Coronavirus disease 19 infection Ultrasonography alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Olavs Hospital Drammen Hospital, Haukeland University Hospital, Helse Stavanger HF, Nordlandssykehuset HF, Sorlandet Hospital, Sykehuset Telemark, Ullevaal University Hospital, University Hospital, Akershus Norway 2020-07-01 2025-12-31 COVIDUS-NOR, NCT04422691, REK129805 Phase Not Applicable Not yet recruiting 9 66 Months 200 Anders B Martinsen, MD, Benedicte Severinsen, MD, Eirik H Ofstad, MD, PhD, Harry Achterberg, MD, Jay Shyamal Chotai, MD, Jørn Rasmussen, MD, Lars E Næss-Pleym, Lars Petter Bjørnsen, MD, PhD, Rune Bjørneklett, MD, PhD, Øistein Rønneberg Mjelva, MD, PhD 2020-06-12
Fibromyalgia During the Covid-19 Pandemic Coronavirus disease 19 infection, Fibromyalgia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Al-Azhar University Egypt 2020-03-15 2020-06-30 AAGH-01, NCT04422522 Phase Not Applicable No longer recruiting 1 3 Months 45 Ahmed Abogamal 2020-06-12
PTT-Online: Video Dance Class and Unsupervised Physical Activity During Covid-19 Pandemic in People With Parkinson's Disease Coronavirus disease 19 infection, Parkinsons disease video dance classes alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Federal University of Rio Grande do Sul Brazil 2020-05-01 2024-12-30 NCT04422353, PTT-Online, PTT-PARKINSON/COVID19 Phase Not Applicable Recruiting 1 55 Months 60 Aline N. Haas, PhD, Elren P. Monteiro, PhD, Flávia G. Martinez, PhD, Leonardo A Peyré-Tartaruga, PhD, Leonardo A. Peyré-Tartaruga, Leonardo A. Peyré-Tartaruga, PhD 2020-06-12
COV-BARRIER: A Study of Baricitinib (LY-3009104) in Participants With COVID-19 Coronavirus disease 19 infection, Viral pneumonia Background therapy alone, baricitinib alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eli Lilly & Co US, Spain, Mexico, Germany 2020-05-29 2020-09-01 17830, 2020-001517-21, COV-BARRIER, I4V-MC-KHAA, NCT04421027 Phase 3 Clinical Recruiting 15 3 Months 400 Adrian Camacho Ortiz, Andrew Catanzaro, Dora Patricia Cornejo Juárez, Gustavo Rojas Velasco, Luis Enrique Soto Ramírez, Mark MacElwee, Michel Fernando Martínez Reséndez, Miriam Akasbi, Patrick Milligan, Phyllis Tien, Roberto Caricchio, Thomas Grunewald, Thomas Lawrie, Vicente Estrada, Vinay Malhotra 2020-06-18
HEART-COVID: Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children Coronavirus disease 19 infection, Myocarditis Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Assistance Publique Hopitaux de Paris France 2020-06-30 2020-12-31 APHP200632, HEART-COVID, NCT04420468 Phase Not Applicable Not yet recruiting 4 6 Months 20 Clémence Marais, MD, Hélène Morel, Julie Starck, MD, Marion Grimaud, Marion Grimaud, MD, Michäel Levy, MD, Sylvain Renolleau, MD, PhD 2020-06-11
PAPESCO-19: Patients and Health Staff of Cancer Centres During the Covid-19 Pandemic Coronavirus disease 19 infection ELISA alone, RT-PCR alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut De Cancerologie De L'Ouest France 2020-06-15 2022-06-15 ICO-2020-16, NCT04421625, PAPESCO-19 Phase Not Applicable Not yet recruiting 1 24 Months 12000 Magali Briere, Magali Brière, Michele Boisdron-Celle, Michelle Boisdron-Celle 2020-06-19
Magnetic Resonance Imaging to Detect Signs of Viral Pneumonia in Patients With Coronavirus Infection Coronavirus disease 19 infection, Lung injury, Viral pneumonia chest magnetic resonance imaging alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Research and Practical Center of Medical Radiology, Department of Health Care of Moscow Russian Federation 2020-05-19 2021-06-20 2020-2, NCT04424355 Phase Not Applicable Recruiting 1 13 Months 115 Olga Panina, Sergey Morozov, Yuri Vasilev 2020-06-17
FCFM: Forecasting COVID-19 for Malaysia Coronavirus disease 19 infection Government of Malaysia Malaysia 2020-06-05 2022-05-31 FCFM, NMRR-20-1109-54838 Phase Not Applicable Not yet recruiting 1 23 Months Devi Peramalah, Prof. Dr Jamalludin Ab Rahman 2020-06-11
A phase II trial to assess Metablok in the prevention of acute organ inflammation and injury experienced by patients with COVID-19 Acute lung injury, Coronavirus disease 19 infection, Inflammatory disease, Renal injury, Respiratory distress syndrome Metablok alone Dehydropeptidase-1 modulator Arch Biopartners Inc US Phase 2 Clinical Planned 1 2020-06-10
DRDMMICPINSL Coronavirus disease 19 infection Robust Disease Modelling alone Government of Malaysia Malaysia 2020-06-04 2022-05-31 54839, NMRR-20-1102-54839 Phase Not Applicable Not yet recruiting 1 23 Months Devi Peramalah, he agent-based model 2020-06-11
PICOVID Coronavirus disease 19 infection povidone iodine alone Hospital Sungai Buloh Malaysia 2020-06-05 2020-07-01 54946, NMRR-20-1099-54946 Phase 2 Clinical Status not specified 1 60 Dr Shiraz Qamil bin Muhammad Abdul Kadar, dr IFFAH BINTI SALIM 2020-06-11
A randomized, double-blind, placebo-controlled, phase II study to assess the longer-term efficacy and safety pamrevlumab in patients who recovered or are recovering from COVID-19 infection with evidence of interstitial lung disease Coronavirus disease 19 infection, Interstitial lung disease pamrevlumab alone Connective tissue growth factor ligand inhibitor FibroGen Inc US Phase 2 Clinical Planned 1 2020-06-10
BOREA: An open-label, phase II/III, randomized, parallel-arm , investigator-initiated study to evaluate the efficacy and safety of pamrevlumab versus standard of care in patients with severe coronavirus 2019 (COVID-19) infection Coronavirus disease 19 infection pamrevlumab alone Connective tissue growth factor ligand inhibitor FibroGen Inc Italy 2020-06-08 BOREA Phase 2/Phase 3 Clinical Recruiting 1 68 Professor Luca Richeldi 2020-06-10
DiSurE-Covid19: Evaluation of COVID-19 Surveillance Programme in University Malaya Medical Center Coronavirus disease 19 infection University Malaya Medical Centre Malaysia 2020-06-15 2022-08-31 55160, DiSurE-Covid19, NMRR-20-1097-55160 Phase Not Applicable Status not specified 2 26 Months Diane Chong Woei Quan 2020-06-11
Acceptance and Perception of the COVID-19 vaccination in the general population of Malaysia Coronavirus disease 19 infection COVID-19 vaccination alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institutes of Health Malaysia Malaysia 2020-06-02 2020-11-30 55153, NMRR-20-1089-55153 Phase Not Applicable Not yet recruiting 1 5 Months Dr June Lau Fei Wen 2020-06-11
A clinical study of camostat mesylate for the treatment of patients with COVID-19 infection Coronavirus disease 19 infection camostat mesylate alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Ono Pharmaceutical Co Ltd Phase Not Applicable Planned 0 2020-06-10
A clinical study on the safety of camostat mesilate in healthy volunteers Coronavirus disease 19 infection camostat mesylate alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Healthy volunteers accepted Ono Pharmaceutical Co Ltd 2020-06-05 Phase Not Applicable Recruiting 0 2020-06-10
SUCCESS: Surveillance of SARS-CoV-2 Virus Antibody in Health Care and Close-Contact Workers Coronavirus disease 19 infection COVID-19 antibody laboratory test alone, COVID-19 antibody point-of-care test kit alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kinki Health Administration Center (KKC), Mie Health Checkup Clinic Japan 2020-06-10 2021-07-31 SUCCESS, UMIN000040694 Phase Not Applicable Not yet recruiting 1 13 Months 1000 Masakatsu Nishikawa 2020-06-10
YOCO: Yoga Pranayama Adjuvant to Treat Burden COVID-19 Coronavirus disease 19 infection Morning pranayama alone, Pre dinner pranayama alone, Pre lunch pranayama alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Health Ricerca e Sviluppo Srl Casa di Riposo e Ambulatorio Giardino St Lucia, Massa Lomabarda (Ra) Italy, EJTN GEIE, Halnet Srl, Swami Vivekananda Yoga Anusandhana Samsthana Svyasa, Yoga Experience Association Italy 2020-06-01 2021-09-30 2020-001731-28, 2020_COVID19_YOGA, NCT04413747, YOCO Phase Not Applicable Not yet recruiting 1 16 Months 1000 Boris Bazzani, ERYT, Enrico Ricci, MD, Giorgio Noera, MD, PhD, HR Nagendra., Eng, Luca Ghetti, Eng., Maria Donatella Barbagallo, MD, Maria Luisa Vitobello, Morena Gaddoni, Morena Gaddoni, MD, Nagarathna Raghuram, MD 2020-06-10
DEXDO-COVID: Immunomodulatory Profile of Dexmedetomidine Sedation in Patients Recovering After ARDS Covid-19 Adult respiratory distress syndrome, Coronavirus disease 19 infection, Immune disorder dexmedetomidine alone Alpha 2 adrenoceptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-04-24 2021-02-28 2020-A00799-30, APHP200413, DEXDO-COVID, NCT04413864 Phase 2 Clinical Recruiting 1 10 Months 50 Alexandre Demoule, MD, PhD, Alexandre Demoule, Md, PhD, Alice JACQUENS, Vincent DEGOS, Pr 2020-06-10
Photodynamic Therapy for the Treatment of COVID-19 Coronavirus disease 19 infection Laser acupuncture alone, Methylene blue alone, photobiomodulation alone, photodynamic therapy alone Cairo University 2020-08-31 2021-02-28 CU-NILES/16/20, NCT04416113 Phase Not Applicable Not yet recruiting 0 6 Months 60 Cairo University 2020-06-12
Assessment of N-95 Facemask for Use in COVID-19 Pandemic in Case of Shortage of Personal Protective Equipment Coronavirus disease 19 infection Assembled mask alone, Hans Rudolph mask naso-oral mask alone, Iso-Gard HEPA light Filter 28022 alone, RP Performax SE ELBOW alone, Respironics Performax Whole Face Mask alone, Teleflex Bacterial/Viral filter 1605 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oklahoma US Department of Veterans Affairs US 2020-06-15 2025-05-31 11887, NCT04416919 Phase Not Applicable Not yet recruiting 1 59 Months 20 Ahel El Haj Chehade, MD, Houssein Youness, MD 2020-06-11
Evaluation of the effects of Oxycodone administration on pain control in patients with COVID-19 Coronavirus disease 19 infection, Dyspnea, Pain oxycodone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-03-20 IR.SBMU.NRITLD.REC.1399.012, IRCT20150107020592N24 Phase 3 Clinical Recruiting 1 60 Dr Mahmood Heydari, Dr Seyed Mohamadreza Hashemian, Seyed Mohammad Reza Hashemian 2020-06-10
A Clinical Study to Assess the Natural History of COVID-19 and Effects of KB109 and Supportive Self-care in Outpatients With Mild-to-moderate COVID-19 Coronavirus disease 19 infection KB-109 alone, Self Supportive Care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kaleido Biosciences Inc US 2020-06-30 2020-12-31 K031-120, NCT04414124 Phase 2 Clinical Recruiting 8 6 Months 400 Mark Wingertzahn, PhD 2020-06-11
Clinical Trial On Mildly Symptomatic Covid -19 Patients And Health Care Workers Posted To Covid Wards Coronavirus disease 19 infection A Mulmina Mango alone, Mulmina Amla Orange alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Jagdale industries pvt Ltd India 2020-06-15 CTRI/2020/06/025702, Protocol Version 1.0 Phase 3 Clinical Not yet recruiting 1 80 Dr Ashok Godavarthi, Dr C R Jayanthi, Mr Raghavendra K V 2020-06-11
iCOVID19 Project: This study has been conducted to collect the Cough and breathing sound of COVID-19 positive and COVID-19 negative patients for analysis of early indication of COVID-19 in humans Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Imperial Clinical Research Services India 2020-06-15 CTRI/2020/06/025675, iCOVID19 Project Phase Not Applicable Not yet recruiting 1 600 Ajeet Nanda, Amlendu Yadav, Pragya Yadav 2020-06-11
O-CovAb: Oral Fluid Sars-CoV-2 Ab Rapid test Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Diabetes Research Society India 2020-06-16 CTRI/2020/06/025674, O-CovAb Phase Not Applicable Not yet recruiting 3 100 Prof N Partha Sarathy, Prof PV Rao, Prof V Chandrasekhar 2020-06-11
An off-label, prospective, observational study to assess the effect of acalabrutinib in patients with acute respiratory distress syndrome (ARDS) from COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome acalabrutinib alone Btk tyrosine kinase inhibitor AstraZeneca plc, US Oncology Inc National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Walter Reed Army Medical Center US Phase Not Applicable Status not specified 3 19 2020-06-10
Validating an ELISpot for Early Detection of an Active Immune Response Against COVID-19 Coronavirus disease 19 infection ELISpot alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Nice France 2020-06-01 2021-06-01 20-PP-10, NCT04418206 Phase Not Applicable Not yet recruiting 4 12 Months 300 DUMON MARIE CHRISTINE, LEROUSSEAU LIONEL, LEROY SYLVIE, LEROY Sylvie, Leroy Sylvie, Rolland Fabien, griffonnet Jennifer, lerousseau lionel, rolland Fabien 2020-06-11
Investigation of the effects of prone position on cardiac and respiratory status in patients with coronavirus Coronavirus disease 19 infection, Respiratory disease prone position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Lorestan University Iran 2020-06-21 IR.LUMS.REC.1399.059, IRCT20160126026217N4 Phase Not Applicable Not yet recruiting 1 74 Ebrahim Falahi, Sajad Yarahmadi 2020-06-11
Prospective, cohort study of COVID-19 antibody for medical stuff in hospital Coronavirus disease 19 infection Gunma Prefectural Cancer Center Japan 2020-06-08 UMIN000040679 Phase Not Applicable Not yet recruiting 1 50 Kazuhiro Araki 2020-06-10
Longitudinal study on work style change, health and well-being due to pandemic of novel coronavirus infection (COVID-19) Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Keio University Atrae Inc, Nittsu System Co Ltd Japan 2020-06-08 20E0004, UMIN000040683 Phase Not Applicable Not yet recruiting 1 2000 Akihito Shimazu, Satoko Fujihara 2020-06-10
A global study of eritoran in hospitalized patients who tested positive with SARS-CoV-2 infection (COVID-19) Coronavirus disease 19 infection eritoran alone TLR-4 antagonist Eisai Co Ltd 2020-06-30 Phase Not Applicable Planned 0 400 2020-06-09
A Phase II clinical trial of AQCH for potential treatment of COVID-19 Coronavirus disease 19 infection AQCH alone Sun Pharmaceutical Industries Ltd India Phase 2 Clinical Not yet recruiting 1 210 2020-06-09
Ulinastatin for COVID-19 in patients with breathlessness Coronavirus disease 19 infection, Respiratory distress syndrome Variable regimens including azithromycin , hydroxychloroquine , ulinastatin (sepsis/acute pancreatitis), Bharat Serums and Vaccines Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Bharat Serums & Vaccines Ltd India 2020-07-01 BSV_ULINA_20_03_IN, CTRI/2020/06/025704 Phase 3 Clinical Not yet recruiting 6 120 Dr Amlendu Yaadav, Dr Apurva Agarwal, Dr Dibakar Sahu, Dr Harish Mallapura Maheshwarappa, Dr Madhusudan Jaju, Dr Rohidas Borse, Dr Shreepad Bhat, Dr Uday Harle 2020-06-11
Phase II study to evaluate the safety and efficacy of 2-Deoxy-D-Glucose in COVID-19 patients Coronavirus disease 19 infection 2-deoxy-D-glucose alone, standard-of-care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Dr Reddy's Laboratories Ltd, Institute of Nuclear Medicine and Allied Sciences (INMAS) India 2020-06-15 CTRI/2020/06/025664, CVD-19-CD-002, Version 2.0 Phase 2 Clinical Not yet recruiting 1 40 D Mallikarjuna Rao, Dr Apurva Agarwal 2020-06-10
To Assess the Safety and Outcome of Herbal Medicine in Prevention of COVID-19 Infection Among High Risk Population Coronavirus disease 19 infection Variable regimens including behidana , khameera marwareed , oshanda , sapistan , unnab Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ministry of Ayush India 2020-06-15 CTRI/2020/06/025650 Phase 2 Clinical Not yet recruiting 1 4000 Prof Abdul Wadud 2020-06-10
In vivo use of ivermectin (IVR) for treatment for corona virus infected patients: a randomized controlled trial Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Rayak Hospital Lebanon, Iraq 2020-06-10 2020-07-31 ChiCTR2000033627 Phase 0 Clinical Not yet recruiting 2 1 Month 60 Dr. Houssam RaaD, Mirna Fawaz 2020-06-10
A study on association between tobacco and COVID 19 to help policy makers Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Scottish Funding Council, University of Edinburgh India 2020-06-15 COVID_IMPACT, CTRI/2020/06/025673 Phase Not Applicable Not yet recruiting 1 50 Muralidhar Kulkarni 2020-06-10
A medical records based study for nano short peptide nutrition intervention on the prognosis of patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Nano short peptide enteral nutrition alone, whole protein enteral nutrition alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The First College Of Clinical Medical Science, China Three Gorges University China 2020-05-07 2020-06-17 ChiCTR2000033609 Phase Not Applicable Not yet recruiting 1 1 Month 206 Ze-Lin Zhang 2020-06-10
Prophylactic study of outbreak of novel coronavirus in Indian scenario in Distric Hospital, Vidisha Coronavirus disease 19 infection piper betal plus swarnabhasma Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Government medical college, Bhopal India 2020-06-22 CTRI/2020/06/025637 Phase Not Applicable Not yet recruiting 1 10 Dr Sarvesh Sharma 2020-06-10
Analysis of Characteristics of recurrent positive RT-PCR findings of recovered patients from novel coronavirus pneumonia (COVID-19) in Wuhan, China: a medical records based study Coronavirus disease 19 infection, Viral pneumonia Yunnan Center for Disease Control and Prevention China 2020-01-01 2020-03-20 ChiCTR2000033580 Phase Not Applicable Completed 1 2 Months 758 SHUI TIEJUN 2020-06-10
To evaluate the effect of herbal medicine in prevention and management of COVID-19 Coronavirus disease 19 infection Joshanda (Decoction) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Ministry of Ayush, National Institute of Unani Medicine India 2020-06-15 CTRI/2020/06/025672 Phase 2/Phase 3 Clinical Not yet recruiting 1 60 Dr Fasihur Rehman Ansari, Dr Mariyam Ahad, Dr Mohd Aleemuddin Quamri 2020-06-10
A clinical trial to evaluate the medicinal efficacy of Ayurvedic Tablet Bhoumya and Tablet Saathmya in COVID-19 positive Patients Coronavirus disease 19 infection, Viral pneumonia standard care alone, Bhoumya plus Saathmya Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Prashanthi Ayurvedic Centre India 2020-06-15 CTRI/2020/06/025671 Phase 3 Clinical Not yet recruiting 1 10 Dr C R Jayanthi, Dr Giridhara Kaje, Dr Harish M 2020-06-10
PREVENGHO-COVID: PrevengHo-Vir Homeoprophylaxis COVID-2019 Coronavirus disease 19 infection PrevengHo-Vir alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Instituto Pedro Kouri Cuba 2020-04-29 2020-12-31 PREVENGHO-COVID, RPCEC00000312 Phase 1 Clinical Recruiting 1 8 Months 180 Carlos Eugenio Royo Lafita, Elsida Lucía Rey Robira, Johann Perdomo Delgado 2020-06-10
CIGB-258 at COVID-19 Coronavirus disease 19 infection CIGB-258 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Genetic Engineering and Biotechnology Instituto Pedro Kouri Cuba 2020-03-31 2020-04-30 CIGB-258/2020, RPCEC00000313 Phase 2 Clinical No longer recruiting 1 1 Month 16 Daniel González, Maria Carmen Domínguez Horta, Rafael Venegas Rodriguez 2020-06-15
Convalescent Antibodies Infusion in COVID-19 Patients Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia anti-coronavirus antibody therapy alone, double-filtration plasmapheresis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ospedale Papa Giovanni XXIII Aferetica Srl Italy 2020-06-30 2020-09-30 DFPP COVID 19 EARLY, NCT04418531 Phase 2 Clinical Not yet recruiting 6 3 Months 10 Anna Falanga, MD, Annapaola Callegaro, MD, Claudio Farina, MD, Diego Curtò, MD, Federica Casiraghi, Ferdinando Luca Lorini, MD, Giuseppe Remuzzi, MD, Laura Castellani, Biol.Sci.D, Lorenzo Grazioli, MD, Luca Barcella, MD, Marina Marchetti, Biol.Sci.D, Marina Noris, Ch., Piero Luigi Ruggenenti, Piero Luigi Ruggenenti, MD, Roberto Cosentini, MD, Stefano Rota, MD 2020-06-10
Peri-Operative NLR in Emergency General Surgery During COVID-19 Pandemic Coronavirus disease 19 infection emergency general surgery alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Barking Havering & Redbridge University Hospitals Nhs Trust UK 2020-03-23 2020-06-30 133196, NCT04419571 Phase Not Applicable No longer recruiting 1 3 Months 100 Nader Habib Bedwani 2020-06-10
Online Learning of Veterinary Anatomy During COVID-19 Pandemic Coronavirus disease 19 infection online survey alone, online veterinary anatomy learning alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs) South Valley University Egypt 2020-06-05 2020-07-05 2-2020, NCT04418284 Phase Not Applicable Recruiting 1 1 Month 400 Mohamed Mahdy 2020-06-17
Vocal Feature Analysis Algorithm Coronavirus disease 19 infection Vocal Feature Analysis (VFA) algorithm app (Soniphi) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Soniphi LLC UserWise US 2020-06-30 2020-12-31 002 SONIPHI, NCT04418544 Phase Not Applicable Recruiting 1 6 Months 400 Lauren Vitalie, BA, Matthew Sanderson, BS 2020-06-08
COVID-HOP: Establishment of a Biological Collection During COVID-19 Serological Screening in APHP Professionals Coronavirus disease 19 infection biological sampling alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris Fondation Hôpitaux de Paris-Hôpitaux de France France 2020-06-30 2022-03-31 2020-A01364-35, APHP200609, COVID-HOP, NCT04418375 Phase Not Applicable Not yet recruiting 5 21 Months 4000 Béatrice Dr PARFAIT, PhD, Bénédicte Dr SAWICKI, PhD, Marie Dr COURBEBAISSE, MD, PhD, Martine Dr LOUET, PhD, Nathalie Dr DEMORY, PhD, Solen Dr KERNEIS, PhD, Véronique Dr MAHE, PhD 2020-06-12
Effect of Dinvl on improving of clinical and paraclinical symptoms in patients with COVID-19 Coronavirus disease 19 infection Dinvl herbal medicine alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zahravi drug company Iran 2020-06-20 IR.TBZMED.REC.1399.135, IRCT20200518047497N2 Phase 3 Clinical Not yet recruiting 1 80 Azizeh Farshbaf-Khalili, Javad Ahmadian Heris 2020-06-09
CONCOR-1: A Trial of Convalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness Coronavirus disease 19 infection, Respiratory disease Convalescent plasma alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Weill Medical College of Cornell University Hamilton Health Sciences Corp US 2020-06-30 2021-12-31 20-04021981, CONCOR-1, NCT04418518 Phase 3 Clinical Not yet recruiting 2 18 Months 1200 Celine Arar, Marshall Glesby, MD, Marshall Glesby, MD, PhD 2020-06-10
PPT-COVID: Patient Preference Trial for COVID-19 Coronavirus disease 19 infection, Viral pneumonia chloroquine alone, hydroxychloroquine alone, azithromycin plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Princesse Grace Monaco 2020-04-06 2020-09-01 20-08, NCT04418193, PPT-COVID Phase Not Applicable Recruiting 1 4 Months 100 Atul PATHAK, MD PhD, Celine DUGOURD 2020-06-10
VIVALDI: COVID-19 in care homes Coronavirus disease 19 infection Baseline assessment and antibody testing alone, Intensive testing for infection (PCR and antibody) alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of London National Institute for Health Research (NIHR) UK 2020-05-28 2021-11-30 CPMS 45953, IRAS 284545, ISRCTN14447421, VIVALDI Phase Not Applicable Recruiting 2 18 Months Dr Maria Krutikov, Dr Shallcross 2020-06-10
Neuro-COVID: Neurological Complications of COVID-19 Coronavirus disease 19 infection, Neurological disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Zurich Switzerland 2020-05-01 2022-05-30 NCT04418609, NEURO-COVID-19, Neuro-COVID Phase Not Applicable Recruiting 1 24 Months 30 Emanuela Keller, Prof. Dr. 2020-06-09
COVIDOB: COVID-19 and Obstetric Transmission Coronavirus disease 19 infection RT-PCR alone, antibody testing alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University Hospitals Of Cleveland Case Western Reserve University, Cleveland Clinic Foundation, Cuyahoga County Board of Health, MetroHealth Medical Center US 2020-04-28 2021-07-31 20200479, COVIDOB, NCT04418557 Phase Not Applicable Recruiting 1 15 Months 200 Rachel Pope, Rachel Pope, MD, MPH 2020-06-10
A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer Coronavirus disease 19 infection, Viral pneumonia TL-895 alone, standard available treatment alone Btk tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Telios Pharma, Inc 2020-06-30 2021-07-31 NCT04419623, TL-895-202 Phase 1/Phase 2 Clinical Not yet recruiting 0 13 Months 146 John Mei 2020-06-19
Effect of bee products on COVID-19 Coronavirus disease 19 infection Variable regimens including N-chromosome royal jelly , honey , propolis Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-05-30 IR.SBMU.NRITLD.REC.1399.048, IRCT20200209046427N1 Phase Not Applicable Recruiting 1 60 Afshin Zarghi, Shadi Shafaghi 2020-06-15
CORDA: Covid Radiographic Images Data-set for AI Coronavirus disease 19 infection, Viral pneumonia chest x-ray radiography alone, neural network algorithm diagnosis alone Azienda Ospedaliera Citta della Salute e della Scienza di Torino Azienda Ospedaliera Ordine Mauriziano di Torino, University of Turin Italy 2020-03-24 2021-03-31 CORDA, CORDA, NCT04419545 Phase Not Applicable Recruiting 1 12 Months 2500 Andrea Ferraris, M.D., Claudio Berzovini, M.D., Francesca Santinelli, M.Sc., Giorgio Limerutti, M.D., Marco Calandri, M.D., Marco Grosso, M.Sc., Paolo Fonio, M.D., Patrizia Sardo, M.D., Simona Capello, M.D., Stefano Tibaldi, M.Sc. 2020-06-10
COVID-US: Confirmation of Ventilation and Intubation by Determination With Ultrasonography Coronavirus disease 19 infection lung ultrasonography alone, tracheal ultrasonography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Pittsburgh Baylor College of Medicine, Cleveland Clinic Foundation, Kadlec Regional Medical Center, Oregon Health Sciences University US 2019-01-01 2020-05-30 COVID-US, NCT04419064, STUDY20050011 Phase Not Applicable Completed 4 16 Months 118 Mourad H Senussi, MD, MS 2020-06-09
A phase I clinical study of EXG-5003 for the potential treatment of COVID-19 Coronavirus disease 19 infection EXG-5003 alone COVID19 Spike glycoprotein modulator Elixirgen Therapeutics Inc US Phase 1 Clinical Planned 1 2020-06-11
A clinical study to assess QuadraMune in the treatment of patients suffering from COVID-19 and/or individuals at risk of COVID-19 Coronavirus disease 19 infection QuadraMune alone Therapeutics Solutions International Inc Phase Not Applicable Planned 0 2020-06-08
A pilot clinical feasibility study to assess QuadraMune in healthy subjects in the prevention of COVID-19 Coronavirus disease 19 infection QuadraMune alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Therapeutics Solutions International Inc Phase 1 Clinical Status not specified 0 32 2020-06-08
RAS and Coagulopathy in COVID-19 Blood clotting disorder, Coronavirus disease 19 infection TRV-027 alone Angiotensin II AT-1 receptor antagonist, Beta-arrestin stimulator Aged Adults (65-79 yrs), Elderly Adults (80 and over) Imperial College London UK 2020-07-31 2021-01-31 283093, NCT04419610 Phase 0 Clinical Not yet recruiting 1 6 Months 60 DAVID OWEN, David Owen, Katrina Pollock, Lisa Hurley 2020-06-18
Living With Sickle Cell Disease in the COVID-19 Pandemic Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Sickle cell anemia, Sleep disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Human Genome Research Institute National Institutes of Health Clinical Center US 2020-06-24 2024-12-31 20-HG-N125, 999920125, NCT04417673 Phase Not Applicable Not yet recruiting 1 54 Months 700 Nathan Jones, Vence L Bonham, J.D. 2020-06-19
Retrospective examination of the course of a Covid-19 infection in patients with inflammatory bowel disease Coronavirus disease 19 infection, Inflammatory bowel disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CSG - Clinische Studien Gesellschaft GmbH Germany 2020-04-21 2020-1705-Reg, DRKS00021653 Phase Not Applicable Recruiting 1 500 Niels Teich 2020-06-08
COVID-PraxImmun: Investigation of the immune status against SARS-CoV-2 of medical professionals in Doctor's Practices in Thuringia (COVID-19 research project) Coronavirus disease 19 infection Lateral-Flow-Assay IgM/IgG alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over), European Ancestry Association of Statutory Health Insurance Physicians North Rhine Zentralinstitut für die kassenärztliche Versorgung in der Bundesrepublik Deutschland Germany 2020-06-30 22860/2020/57, COVID-PraxImmun, DRKS00021815 Phase 4 Clinical Not yet recruiting 1 10000 Anke Möckel, Thomas Schröter 2020-06-08
COVIDLight: Vielight RX Plus for the Treatment of COVID-19 Respiratory Symptoms Coronavirus disease 19 infection, Respiratory disease Vielight RX Plus alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Vielight Inc. Canada 2020-07-01 2021-01-01 COVIDLight, NCT04418505, VL-2020-02 Phase Not Applicable Not yet recruiting 1 6 Months 280 Andrea Berk, Roy Tingley, MD 2020-06-10
COVID 19-IA: CT Biomarkers Identification by Artificial Intelligence for COVID-19 Prognosis Coronavirus disease 19 infection, Lung injury deep learning artificial intelligence alone, thoracic computed tomography scan alone Centre Hospitalier Universitaire de Nimes Martinique, France 2020-03-01 2020-07-31 COVID 19-IA, NCT04418245, NIMAO/2020/COVID 19-IA/JF-01 Phase Not Applicable No longer recruiting 6 5 Months 1000 Julien Frandon 2020-06-10
Clinical Efficacy of Nafamostat Mesylate for COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia antibiotic agents therapy alone, continuous renal replacement therapy (CRRT) alone, extracorporeal membrane oxygenation (ECMO) alone, hemodialysis (HD) alone, invasive ventilation therapy alone, non-invasive ventilation therapy alone, supplemental oxygen theray alone, Variable regimens including hydroxychlorquine , lopinavir + ritonavir , nafamostat mesylate HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gyeongsang National University Hospital South Korea 2020-06-10 2021-04-30 2020-04-012, NCT04418128 Phase 2/Phase 3 Clinical Not yet recruiting 1 10 Months 84 IN-GYU BAE, MD, Kyunglan Moon, MD 2020-06-11
Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease Coronavirus disease 19 infection N-acetylcysteine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cambridge Health Alliance US 2020-06-15 2021-03-31 CHA-IRB-1139/05/20, NCT04419025 Phase 4 Clinical Not yet recruiting 1 9 Months 200 Duncan Kuhn, MD, Melisa Lai-Becker, Melisa Lai-Becker, MD 2020-06-10
A phase I clincal study to test the efficacy of Carragelose for the trearment of viral pneumonia, SARS-CoV-2 and other viruses of the respiratory tract Coronavirus disease 19 infection, Respiratory tract infection, Viral pneumonia Carragelose alone Marinomed Biotechnologie GmbH Phase 1 Clinical Planned 0 2020-06-09
Effect of Umifenovir in treatment of covid-19 Coronavirus disease 19 infection Arbidol plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tehran University of Medical Sciences Iran 2020-04-20 2020-05-25 IR.TUMS.VCR.REC.1399.204, IRCT20200523047550N1 Phase 3 Clinical Completed 1 1 Month 50 Sara Ghaderkhani 2020-06-09
A clinical trial of pritumumab for the potential treatment of COVID-19 infection Coronavirus disease 19 infection pritumumab alone Vimentin modulator Nascent Biotech Inc Phase Not Applicable Planned 0 2020-06-08
Difficulty in doing usual work after wearing personal protective equipment Coronavirus disease 19 infection Personal Protective Equipment alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) All India Institute of Medical Sciences India 2020-06-04 CTRI/2020/06/025560  Phase Not Applicable Not yet recruiting 1 50 Dr Puneet Khanna 2020-06-08
Homoeopathic Medicines Bryonia alba 30C as a Prophylaxis for COVID-19 Coronavirus disease 19 infection Bryonia alba alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Principal Aarogya Homoeopathic Medical College and Hospital Ministry of Ayush India 2020-06-15 CTRI/2020/06/025558 Phase 4 Clinical Not yet recruiting 1 300 Dr Dan Singh Meena, Prof Dr Puneet R Shah 2020-06-09
DAWN AntiCo: A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19 Coronavirus disease 19 infection Aprotinin alone, anakinra alone, enoxaparin sodium alone, nadroparin calcium alone Low molecular weight heparin, Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) UZ Leuven-University Hospitals Belgium 2020-05-20 2020-001739-28, DAWN AntiCo, S63979 Phase 2 Clinical Recruiting 1 Caroline Devooght 2020-06-08
COVID-PREVENT: Effect of Anticoagulation Therapy on Clinical Outcomes in COVID-19 Arterial thrombosis, Coronary artery disease, Coronavirus disease 19 infection, Deep vein thrombosis, Diabetes mellitus, Lung embolism, Myocardial infarction, Nicotine dependence, Stroke, Thromboembolism rivaroxaban alone Factor Xa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Charite University Bayer AG, Deutsches Zentrum für Herz-Kreislauf-Forschung Germany 2020-06-15 2021-05-30 2020-002282-33, COVID-PREVENT, COVID-PREVENT, NCT04416048 Phase 3 Clinical Not yet recruiting 27 11 Months 400 Andreas Zeiher, Prof. Dr., Aviva Raatz, Dr., Burkhard Pieske, Prof. Dr., Carsten Büning, Prof. Dr., Christiane Erley, Prof. Dr., Christoph Stellbrink, Prof. Dr., Co-PI: Andreas M. Zeiher, Prof. Dr., Co-PI: Steffen Massberg, Prof. Dr., Co-PI: Ursula Rauch-Kröhnert, Prof. Dr., Dennis Wolf, PD Dr., Fabrizio Esposito, Dr., Hans-Christian Mochmann, Dr., Hans-Heinrich Minden, Dr., Ingo Eitel, Prof. Dr., Jakob Ledwoch, Dr., Jan Beyer-Westenhoff, PD Dr., Jan Cornely, Kurt Rasche, Prof. Dr., Leonhard Bruch, Dr., Martin Witzenrath, Prof. Dr., Olaf Göing, Dr., Sebastian Schellong, Prof. Dr., Stefan Felix, Prof. Dr., Steffen Behrens, Prof. Dr., Steffen Massberg, Prof. Dr., Steffen Schön, Prof. Dr., Thomas Münzel, Prof. Dr., Tim Seidler, Prof. Dr. med., Timm Westhoff, Prof. Dr., Ulf Landmesser, Prof. Dr., Ursula Rauch-Kroehnert, Prof. Dr. med., Uta Merle, Prof. Dr. 2020-06-08
COACHING FOR COVID-19: A Pilot Study Investigating the Effectiveness of Coaching on Psychological Outcomes in Hospital-Based Senior Doctors Acute stress disorder, Coronavirus disease 19 infection coaching sessions alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) South Western Sydney Local Health Network Liverpool Hospital Australia 2020-06-05 ACTRN12620000636954p Phase Not Applicable Not yet recruiting 1 35 A/Prof Samuel Harvey, Dr Sarah Dalton, Ms Rita Holland 2020-06-14
Testing an Online Coping Skills Intervention for People Living with Chronic Illness During the COVID-19 Pandemic Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression follow-up questionnaire alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Auckland New Zealand 2020-06-08 ACTRN12620000634976p, U1111-1252-5637 Phase Not Applicable Not yet recruiting 1 46 Dr Anna Serlachius 2020-06-08
INFLAMMACOV: An open, prospective, randomized, therapeutic trial using anakinra or tocilizumab alone or in association with ruxolitinib in severe stage 2b and 3 COVID-19-associated Disease Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Viral pneumonia anakinra alone, tocilizumab (intravenous), Roche/Chugai alone, Variable regimens including anakinra , ruxolitinib , tocilizumab (intravenous), Roche/Chugai IL-6 receptor antagonist, IL-6 receptor modulator, Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor, Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Assistance Publique Hopitaux De Marseille France 2020-09-01 2022-11-01 2020-001754-21, 2020-23, INFLAMMACOV, NCT04424056 Phase 3 Clinical Not yet recruiting 2 26 Months 216 Gilles Kaplanski, Gilles Kaplanski, MD 2020-06-10
A Study of Opaganib in Coronavirus Disease 2019 Pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia opaganib alone, standard of care alone Dihydroceramide delta 4 desaturase inhibitor, Sphingosine kinase 2 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) RedHill Biopharma Ltd US 2020-06-11 2020-12-31 ABC-110, NCT04414618 Phase 2a Clinical Recruiting 2 6 Months 40 Kevin Winthrop, MD, MPH, Mark L Levitt, MD, PhD, Vered Katz Ben-Yair, MSc 2020-06-15
SAVE-ICU: Sedating With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival Anesthesia, Coronavirus disease 19 infection isoflurane alone, sevoflurane alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sunnybrook Health Sciences Centre Canada 2020-06-15 2022-06-15 2149, NCT04415060, SAVE-ICU Phase 3 Clinical Not yet recruiting 2 24 Months 752 Angela Jerath, MD, Brian Cuthbertson, MD, Claudio Martin, MD, Marat Slessarav, MD, Marat Slessarev, MD 2020-06-12
Hydroxychloroquine to Prevent SARS-CoV-2 Infection Coronavirus disease 19 infection hydroxychloroquine alone, standard personal protection measure alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidad Peruana Cayetano Heredia Peru 2020-06-30 2020-10-31 202087, 20923, NCT04414241 Phase 3 Clinical Not yet recruiting 4 4 Months 320 Aldo Lucchetti, MD, Alejandro Llanos, MD, PhD, Alonso Soto, MD, MSc, PhD, Alvaro Schwalb, MD, César Ugarte-Gil, MD, MSc, PhD, Eduardo Gotuzzo, MD, Fernando Mejia, MD, MSc, Manuel Espinoza, MD, Max Grogl, PhD, Patricia García, MD, MPH, PhD, Rosio Guerra, MD, MPH 2020-06-08
Effects of a N95 Respirator versus Cloth Mask on Exercise Capacity During Treadmill Exercise Coronavirus disease 19 infection Cloth Face Mask alone, Modified Balke Treadmill test alone, N-95 Respirator alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cleveland Clinic Foundation US 2020-06-01 2020-08-01 20-538, NCT04415879 Phase Not Applicable Recruiting 2 2 Months 20 Debasis Sahoo, Matthew Kampert 2020-06-10
COVID19 Clinical Predictors and Outcome Coronavirus disease 19 infection, Respiratory failure Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St George's University Hospitals NHS Foundation Trust St Georges University of London UK 2020-06-15 2022-04-30 2020.0115, NCT04416347 Phase Not Applicable Not yet recruiting 1 22 Months 800 Timothy D Planche, Dr. 2020-06-08
PROTECT-COVID-19: Conestat Alfa in the Prevention of Severe SARS-CoV-2 Infection in Hospitalized Patients With COVID-19 Acute lung injury, Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia conestat alfa alone, standard of care alone Complement C1s subcomponent inhibitor, Kallikrein modulator, Mannan-binding lectin serine protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Pharming Group NV, University Hospital Basel Pharming Technologies BV Switzerland 2020-06-30 2021-07-31 2020-01252, ME20OSTHOFF3, NCT04414631, PROTECT-COVID-19 Phase 2 Clinical Not yet recruiting 1 13 Months 120 Marten Trendelenburg, Prof. med, Michael Osthoff, PD Dr. med, Michael Osthoff, PD Dr. med., Parham Sendi, Prof. med., Stephan Moser, MD 2020-06-08
Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia mesenchymal stem cells alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Instituto Nac De Ciencias Medicas Y Nutricion Salvador Zubiran Mexico 2020-05-01 2021-05-01 NCT04416139, SCI-3354-20-21-1 Phase 2 Clinical Recruiting 1 12 Months 10 Carlos A Aguilar-Salinas, MD, Carlos Aguilar-Salinas, MD, Martin Iglesias, MD 2020-06-08
USZ BioResource COVID Coronavirus disease 19 infection blood sampling for biobank alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Zurich Switzerland 2020-04-09 2022-04-30 CTC HFV2, NCT04414657 Phase Not Applicable Recruiting 1 24 Months 500 Anja Eskat, PhD, Regina Grossmann, Dr med, Silke Ludwig, MSc 2020-06-08
COVID-19: The Role of a Private Hospital in Hong Kong Amid COVID-19 Pandemic Coronavirus disease 19 infection COVID-19 diagnostic test alone Hong Kong Sanatorium & Hospital Hong Kong 2020-05-25 2020-08-31 COVID-19, NCT04416061, RC-2020-08 Phase Not Applicable No longer recruiting 1 3 Months 2500 Jonpaul Sze Tsing Zee, MBChB 2020-06-08
ERSul study: Sulodexide in the treatment of COVID-19 Coronavirus disease 19 infection conventional treatment alone, sulodexide alone Heparin agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CLINEDEM, Mexico Alfasigma SpA Mexico 2020-04-15 2020-11-30 ERSul study, ISRCTN59048638 Phase 4 Clinical Not yet recruiting 1 7 Months 600 Dr Alejandro Jose Gonzalez Ochoa 2020-06-08
Evaluation of chloroquine blood levels Coronavirus disease 19 infection, Plasmodium vivax infection chloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Fundacao Oswaldo Cruz (Fiocruz) Brazil 2017-05-08 2017-05-08 2.044.073, CAAE 67860317.3.0000.5409, RBR-6mjqrf, U1111-1252-6561 Phase 1/Phase 2 Clinical Completed 1 32 Douglas Pinto 2020-06-09
COOPCOVID-19: Treatment of Patients With COVID-19 With Convalescent Plasma Coronavirus disease 19 infection convalescent plasma alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Faculdade de Ciências Aplicadas (FCA) da UNICAMP, Fundacao Hemocentro de Ribeirao Preto, Hospital Of Syrian Lebanese Itatiba S/C Ltd, Ministry of Science and Technology, Brazil, Sociedade Beneficente Israelita Brasileira Hospital Albert Einsten Brazil 2020-06-01 2022-05-22 COOP-COVID-19-MCTIC, COOPCOVID-19, NCT04415086 Phase 2 Clinical Recruiting 1 23 Months 120 Denivalda SG Araujo, Esper G Kallas, PhD MD, Esper G Kallás, PhD, MD, Natália B Cerqueira, Zelinda B Nakagawa, MsC, Zelinda Maria B Nakagawa 2020-06-10
ReCOVER: Evaluation of a Remote Monitoring Smartphone Application and Care Model of COVID-19 Patients in the Community (ReCOVER) Coronavirus disease 19 infection TCC-COVID mHealth solution alone, standard of care treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of New South Wales Health South Eastern Sydney Local Health District, The George Institute for International Health Australia 2020-05-20 2021-05-19 NCT04399109, PID00770, ReCOVER Phase Not Applicable Recruiting 3 12 Months 2000 Benjamin Kwan, Clarissa Susanto, Dr Sze-Yuan Ooi, Jeffrey Post, Kristen Overton, Nigel Lovell, Pamela Konecny, Richard Sullivan, Sze-Yuan Ooi 2020-06-09
Short-term Physical Function Outcomes in Severe COVID-19 Patients Admitted to ICU for Invasive Mechanical Ventilation Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal Spain 2020-05-15 2020-11-15 165/20, NCT04400461 Phase Not Applicable Recruiting 2 6 Months 50 Irene Lázaro Navarro, PT,MSc,PhD, Luís López-Gónzalez, PT, MSc, Maria Natividad Seisdedos-Nunez, PT, MSc, María-Natividad Seisdedos-Nunez, PT, MSc 2020-06-09
COVRTE-19: Low Dose Pulmonary Irradiation in Patients With COVID-19 Infection of Bad Prognosis Coronavirus disease 19 infection, Respiratory disease, Viral pneumonia low dose lung radiotherapy alone, standard support therapy alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion Hospital Provincial de Castellon Spain 2020-06-01 2021-03-31 COVRTE-19, FHPCS-20-001, NCT04414293 Phase 2 Clinical Not yet recruiting 1 10 Months 41 Carlos Ferrer Albiach, MD, Francisco Garcia Piñón, MSc 2020-06-10
EIKOS: Exploring immunological control mechanisms of SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection ELISA alone, Neutralization assay alone, cytokine release assay alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital of Cologne Deutsches Zentrum für Infektionsforschung Germany 2020-06-05 20-1187, DRKS00021468, EIKOS Phase Not Applicable Not yet recruiting 1 2000 Florian Klein, Henning Grüll 2020-06-06
Quality of life in COVID-19 survivors Anxiety disorder, Coronavirus disease 19 infection, Depression, Fatigue, Post traumatic stress disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Integrated Rehabilitation and Organ Failure Horn Netherlands 2020-05-07 2021-06-01 NL8587 Phase Not Applicable Recruiting 1 12 Months 500 Martijn Spruit 2020-06-09
BCG-PLUS: Enhancing the BCG-induced trained immunity response by addition of bisphosphonate or MMR vaccine: a possible preventive approach against COVID-19 Coronavirus disease 19 infection BCG alone, MMR alone, Variable regimens including BCG , MMR , bisphosphonate Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Radboud University Netherlands Organisation for Scientific Research Netherlands 2020-05-25 2020-06-08 BCG-PLUS, NL8609 Phase 2 Clinical Not yet recruiting 1 100 Priya Debisarun 2020-06-09
Oral Favipiravir for Patients with Delayed SARS-Cov-2 viral RNA Clearance Coronavirus disease 19 infection, Viral infection favipiravir alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Wuhan Huoshenshan Hospital China 2020-03-18 2020-05-12 ChiCTR2000033491 Phase 4 Clinical No longer recruiting 1 1 Month 9 Jiqiu Wen 2020-06-08
A Phase II Study to Evaluate Axatilimab for Hospitalized Patients With Respiratory Involvement Secondary to COVID-19 Coronavirus disease 19 infection, Respiratory disease Standard of care alone, axatilimab alone CSF-1 antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Syndax Pharmaceuticals Inc US 2020-05-30 2020-11-15 NCT04415073, SNDX-6352-0505 Phase 2 Clinical Recruiting 2 5 Months 186 Magdalena Mamczur-Madry, RN, BSN, MS, ACRP-CP, Michael S. Gordon, M.D., Shani Hilliard, Sue Fischer 2020-06-08
ESHAZ: Hydroxychloroquine, Azithromycin and Zinc for the treatment of SARS-Cov2 infection in Senegal. COVID-19 Coronavirus disease 19 infection azithromycin plus hydroxychloroquine Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cheikh Anta Diop University Senegal 2020-06-01 ESHAZ, PACTR202005622389003 Phase 3 Clinical Not yet recruiting 1 384 Cheikh T. NDOUR, Roger TINE 2020-06-08
RESOLUTION: Study of LAU-7b for the Treatment of COVID-19 Disease in Adults Coronavirus disease 19 infection, Lung inflammation, Respiratory distress syndrome fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University/Laurent Pharmaceuticals alone, standard-of-care alone Nuclear factor kappa B gene modulator Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Laurent Pharmaceuticals US, Canada 2020-06-15 2021-01-15 LAU-20-01, NCT04417257, RESOLUTION Phase 2 Clinical Not yet recruiting 7 7 Months 300 Alexandria Flannery, Christian Allard, MD, Danae Tassy, PhD, François Marquis, MD, François Tremblay, MD FRCPC, Guillaume Coté-Maurais, MSc, Jean-Marie Houle, PhD, John Boyd, MD FRCPC, Mylene Roy, Nadia Beaudoin, MSc RRT, Nancy-Lisa Gagné, Radu Pislariu, MD, Ramy Saleh, MD, Sébastien Poulin, MD, Todd Campbell Lee, MD, Vanessa Larouche, Yannick Sardin Laframboise 2020-06-17