Last updated: Dec 20, 2020 - 02:00 GMT

Title Indication Intervention Actions PatientSelection Sponsor Collaborator Country StartDate EndDate Identifiers Phase Recruitment Status Sites Trial Duration Enrollment Count Contacts LastChanged
Ampligen in Chronic Fatigue Syndrome Chronic fatigue syndrome, Coronavirus disease 19 infection rintatolimod alone 2,5-Oligoadenylate synthetase stimulator, Interferon type I receptor agonist, Ribonuclease stimulator, TLR-3 agonist Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) AIM ImmunoTech Inc US AMP 511, NCT00215813 Phase 3 Clinical Recruiting 2 Ann Marie Coverly, Charles Lapp, MD, Charles W. Lapp, M.D., Daniel Peterson, M.D., Daniel Peterson, MD, Diane Young 2020-10-27
A clinical trial to evaluate the sensitivity and specificity of Oxsed RaVid Direct Testing Kit for the diagnosis of COVID-19 Coronavirus disease 19 infection Oxsed RaVid Direct Testing Kit alone Dnafit Life Sciences Ltd UK Phase Not Applicable Completed 0 69 2020-12-19
A clinical trial to evaluate the sensitivity and specificity of Oxsed RaVid Direct Testing Kit for the diagnosis of COVID-19 infection Coronavirus disease 19 infection Oxsed RaVid Direct Testing Kit alone Dnafit Life Sciences Ltd Hong Kong Phase Not Applicable Completed 0 527 2020-12-19
A clinical trial to evaluate the sensitivity and specificity of Oxsed RaVid Direct Testing Kit for the diagnosis of COVID-19 infection Coronavirus disease 19 infection Oxsed RaVid Direct Testing Kit alone Dnafit Life Sciences Ltd UK, China Phase Not Applicable Completed 0 16 2020-12-19
The effect of orange peel and peppermint extract in coronavirus treatment Coronavirus disease 19 infection orange peel and peppermint extract intake alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shahrekord University of Medical Sciences and Health Services Iran 2020-11-25 IR.SKUMS.REC.1399.107, IRCT20110302005952N2 Phase 3 Clinical Recruiting 0 60 Masoud Hafizi Isfahani, Masoud hafizi isfahani, Mehraban Sadeghi, Mohammadali Ghiasi, Reza Imani 2020-12-19
Long-term COVID-19 Immune Response in a Vulnerable Neighbourhood in Argentina Coronavirus disease 19 infection, Dengue virus infection enzyme linked immunosorbent assay alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Italiano de Buenos Aires Hospital de Niños R. Gutierrez de Buenos Aires, Ministerio de Salud de Ciudad Autónoma de Buenos Aires Argentina 2020-12-02 2021-07-01 3545, NCT04673279 Phase Not Applicable Recruiting 1 7 Months 189 Alicia Mistchenko, Phd, Ana Maria Gomez Saldaño, MD MG, Andrea Gamarnick, Phd, Fernan Quiroz, MD MG, Julieta Salto, Lorena Luna, Magdalena Wagner Manslau, Silvana Figar, MD, Silvana Figar, MD MG, Vanina Pagotto, MD MG 2020-12-19
COVIDIABADO: COVID-19 Pandemic Lockdown Effect in Adolescents and Young Adults With Type 1 Diabetes: Positive Results of an Unpreceded Challenge for Telemedicine and Patient Self-management Coronavirus disease 19 infection, Insulin dependent diabetes glucose monitoring alone Adolescents (13-17 yrs), Young Adults (18-44 yrs) Centre Hospitalien Sud Francilien France 2021-01-01 2021-03-31 COVIDIABADO, IDRCB 2020-A02760-39, NCT04669912 Phase Not Applicable Not yet recruiting 1 3 Months 77 Alfred PENFORNIS, MD PhD, Alfred PENFORNIS, MD, PhD, Caroline TOURTE 2020-12-19
COVID-19 Impact on the Lombardy Region's Emergency System Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto di Ricerche Farmacologiche Mario Negri Italy 2020-09-01 2021-07-31 NCT04669925, TSUNAMI Phase Not Applicable No longer recruiting 4 11 Months 10000 Guido Bertolini 2020-12-19
Willingness to receive a vaccination against SARS-CoV-2 (COVID-19) among patients >/= 80 years Coronavirus disease 19 infection Elderly Adults (80 and over) University of Heidelberg Germany 2020-12-17 DRKS00023921, S-924/2020 Phase 4 Clinical Not yet recruiting 4 700 Petra Benzinger 2020-12-19
A Controlled, Phase II/III Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19 Coronavirus disease 19 infection AS-03 plus SCB-2019 COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clover Biopharmaceuticals AUS Pty Ltd Coalition for Epidemic Preparedness Innovations, International Vaccine Institute Australia 2020-12-31 2022-07-31 CLO-SCB-2019-003, NCT04672395 Phase 2/Phase 3 Clinical Not yet recruiting 1 19 Months 34000 Igor Smolenov, MD, PhD, Pilar Rubio, MD, Vincent Mwangi, MD 2020-12-19
Evaluation of Prognostic Modification in COVID-19 Patients in Early Intervention Treatment, a Randomized Clinical Trial Coronavirus disease 19 infection Variable regimens including azithromycin , ivermectin , paracetamol , rivaroxaban Chloride channel modulator, Factor Xa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Coordinacion de Investigacion en Salud Mexico 2020-12-16 2021-02-12 NCT04673214, R-2020-785-176 Phase 3 Clinical Recruiting 0 1 Month 62 ALMA ITALIA GU MARTINEZ, SPECIALIST, ALMA ITALIA GU MARTINEZ, specialist, GILBERTO CR ARTEAGA, SPECIALIST, GILBERTO CR ARTEAGA, specialist 2020-12-19
A clinical trial of BNT-162b2 for the prevention of COVID-19 in immunocompromized patients Coronavirus disease 19 infection BNT-162b2 alone COVID19 Spike glycoprotein modulator BioNTech SE, Pfizer Inc Phase Not Applicable Planned 0 2020-12-19
A clinical trial of BNT-162b2 for the prevention of COVID-19 in children < 12 years Coronavirus disease 19 infection BNT-162b2 alone COVID19 Spike glycoprotein modulator Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) BioNTech SE, Pfizer Inc Phase Not Applicable Planned 0 2020-12-19
A clinical trial of BNT-162b2 for the prevention of COVID-19 in pregnant women Coronavirus disease 19 infection BNT-162b2 alone COVID19 Spike glycoprotein modulator BioNTech SE, Pfizer Inc Phase Not Applicable Planned 0 2020-12-19
CodePRONUT: Prognostic Impact of the Nutritional Status of Individuals Aged >/= 70 Years With SARS-CoV-2 Coronavirus disease 19 infection Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire Dijon France 2020-10-19 2022-01-31 CodePRONUT, NCT04672343, PUTOT AOIC 2020 Phase Not Applicable Recruiting 1 15 Months 300 Alain PUTOT 2020-12-18
GLS-5310 Vaccine for the Prevention of SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection GLS-5310 (GeneOne Life Science Inc) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) GeneOne Life Science Inc South Korea 2020-12-23 2022-12-31 COV2-001, NCT04673149 Phase 1/Phase 2 Clinical Not yet recruiting 1 24 Months 345 Hyojin Lee, M.S., Joel N Maslow, MD. Ph.D., Woo Joo Kim, MD, Ph.D. 2020-12-18
CovIdeDocS: Impact of the Change in Hospital Service of Caregivers During COVID-19 Health Crisis on Operational Strain Coronavirus disease 19 infection online questionnaire alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Direction Centrale du Service de Sante des Armees France 2020-12-31 2021-09-30 2020-COVID19-33, CovIdeDocS, NCT04667962 Phase Not Applicable Not yet recruiting 2 9 Months 302 Céline RAMDANI, MD, PhD, Julien BOUIX 2020-12-18
Comorbidities and Risk Score in COVID-19 Patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Milano-Bicocca Italy 2020-12-31 2021-12-31 COMORBIDITIES, NCT04670094 Phase Not Applicable Not yet recruiting 1 12 Months 2500 Giuseppe Bellelli, Prof., Giuseppe Citerio, Prof., Maria Grazia Valsecchi, Prof., llaria Capua, Prof. 2020-12-18
A clincial trial of VIRALEZE in healthy volunteers Coronavirus disease 19 infection VIRALEZE alone Healthy volunteers accepted Starpharma Holdings Ltd Phase Not Applicable Planned 0 2020-12-18
Role of Hematological Parameters in the Stratification of COVID-19 Disease Severity Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Fatima Memorial Hospital Pakistan 2020-05-01 2020-07-31 FMHCMD, NCT04670328 Phase Not Applicable Completed 1 3 Months 101 Ayaz Lone, MBBS,FCPS, Sadia Taj 2020-12-18
Evaluation of the Efficacy of High-Doses of Methylprednisolone in SARS-CoV2 (COVID-19) Pneumonia Patients Coronavirus disease 19 infection, Viral pneumonia Variable regimens including dexamethasone , methylprednisolone , oxygen Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Unita Sanitaria Locale di Reggio Emilia Italy 2020-12-31 2021-06-30 NCT04673162, RCT-MP-COVID-19 Phase 3 Clinical Not yet recruiting 1 6 Months 260 Carlo Salvarani, MD, Marco Massari, MD, Massimo Costantini, MD, Nicola Facciolongo, MD 2020-12-18
A clinical study of new aerosol inhalation in the treatment of severe patients with respiratory virus infection Coronavirus disease 19 infection, Pneumonia aerosol inhalation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Shanghai Public Health Clinic Center Shanghai Science and Technology Commission China 2021-01-01 2023-12-31 ChiCTR2000040847 Phase 0 Clinical Not yet recruiting 1 36 Months 20 Weihui Fu 2020-12-18
Durability and extent of protection of SARS-CoV-2 antibodies among patients with COVID-19 Coronavirus disease 19 infection Philippine General Hospital Philippine Council for Health Research and Development Philippines 2021-01-01 2023-01-01 PHRR201214-003199 Phase Not Applicable Not yet recruiting 1 24 Months Carol Stephanie C. Tan-Lim, MD, Carol Tan-Lim, Elenore Uy, Eva Maria Cutiongco-de la Paz, MD, Leonila F. Dans, MD, MSc, Ma. Liza Antoinette M. Gonzales, MD, Maria Vanessa Villaruz-Sulit, Marissa M. Alejandria, MD 2020-12-18
Nasal Poly-ICLC (Hiltonol) for Prophylaxis of COVID-19 in Healthy Adults Coronavirus disease 19 infection Poly-ICLC alone Interferon agonist, TLR-3 agonist Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Oncovir Inc University of Calgary Canada 2021-01-15 2024-01-16 NCT04672291, ONV2020-003 Phase 1b Clinical Not yet recruiting 1 36 Months 40 Andres M Salazar, MD, Richard Bhardwaj, MBChB, PhD 2020-12-19
Remdesivir and Convalescent Plasma Therapy for Treatment of COVID-19 Infection in Nepal: A Registry Study Coronavirus disease 19 infection, Respiratory failure convalescent plasma therapy plus remdesivir COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nepal Health Research Council Nepal 2020-11-19 2021-11-19 749-2020, NCT04669990 Phase Not Applicable Recruiting 4 12 Months 2000 Dr. Pradip Gyanwali,MD, Janak Koirala, MD,MPH, Krishna Pokhrel, MD, Rajan Pandey, MD, Saroj Bhattarai, M.Sc, Sher B Kamar, MD, Uday N Singh, MD 2020-12-18
MicrobioCOVID: Role of the Microbiota in the Evolution of the SARS-CoV-2 Disease, COVID-19, in Hospitalized Patients Bacterial infection, Coronavirus disease 19 infection, Viral pneumonia bioinformatic analysis alone, metagenomic sequencing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-12-04 2022-03-31 APHP201083, MicrobioCOVID, NCT04669938 Phase Not Applicable Recruiting 1 15 Months 200 Etienne Ruppé, Xavier Lescure, xavier lescure 2020-12-18
SourceCOVID: Spread Analysis of COVID-19 Outbreak in France by Self-assessment Web-application Coronavirus disease 19 infection web-application alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Weprom Kelindi France 2021-01-31 2021-03-31 NCT04670003, SourceCOVID, WP-2020-05 Phase Not Applicable Not yet recruiting 1 2 Months 20000 Fabrice DENIS, MD, Magali BALAVOINE 2020-12-18
A preliminary, multicentre, real-world study to evaluate the clinical impact of fondaparinux versus enoxaparin on venous thromboembolism prophylaxis among hospitalized COVID-19 patients Coronavirus disease 19 infection, Deep vein thrombosis fondaparinux sodium alone Factor Xa antagonist University of Campania Luigi Vanvitelli Phase 4 Clinical Status not specified 0 2020-12-18
Physical Activity, Exercise Capacity and Coronavirus Phobia of Adult Cystic Fibrosis Patients During COVID-19 Pandemic Coronavirus disease 19 infection, Cystic fibrosis, Phobia video conferencing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hacettepe University Turkey 2020-11-04 2021-11-04 GO 20/794, NCT04673331 Phase Not Applicable Recruiting 1 12 Months 24 Aydan Aslı Aksel, Ebru Damadoğlu, PhD, Merve Fırat, MSc, Naciye Vardar Yağlı, PhD 2020-12-18
A phase II clinical study of AV-001, Vasomume Therapeutics/AnGes for the treatment of patients with moderate-to-severe COVID-19 disease Coronavirus disease 19 infection AV-001, Vasomume Therapeutics/AnGes alone Tek tyrosine kinase receptor stimulator Vasomune Therapeutics Inc Phase 2 Clinical Planned 0 2020-12-18
A phase IIb clinical trial of CM-4620 for the treatment of Coronavirus disease 19 infection Coronavirus disease 19 infection, Inflammatory disease, Pancreatitis, Respiratory failure CM-4620 alone Ca2+ release activated Ca2+ channel 1 inhibitor CalciMedica Inc 2021-03-31 Phase 2b Clinical Planned 0 2020-12-18
Combination therapy of favipiravir, camostat mesilate and inhaled ciclesonide for COVID-19 pneumonia Coronavirus disease 19 infection, Viral pneumonia favipiravir alone, Variable regimens including camostat mesylate , ciclesonide , favipiravir RNA polymerase inhibitor, Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) International University Of Health & Welfare Japan Agency for Medical Research and Development, The University of Tokyo Hospital Japan 2020-11-11 2021-09-30 CRB3180020, jRCTs031200196 Phase 2/Phase 3 Clinical Recruiting 1 10 Months 100 Hideaki Yamazawa, Hiroshi Otsu, Jiro Terada, Kenji Tsushima, Maki Kobayashi, Masaru Miyazaki, Taichi Mochizuki, Tetsuo Sato, Tsutomu Yamazaki, Yumi Tanaka 2020-12-18
Silmitasertib (CX-4945) in Patients With Severe Coronavirus Disease 2019 (COVID-19) (CX-4945) Coronavirus disease 19 infection, Lower respiratory tract infection silmitasertib alone, standard of care alone Casein kinase II inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Arizona Senhwa Biosciences Inc US 2020-12-15 2022-12-31 CX4945-AV02-IIT, NCT04668209 Phase 2 Clinical Not yet recruiting 2 24 Months 40 Anna Valencia, MPH, MBEMH, Christian Bime, MD, Marilyn Glassberg, MD, Stephanie Marsh, BS, Stephanie Marsh, BS, CCRC 2020-12-18
Study on Safety and Clinical Efficacy of Azvudine in COVID-19 Patients (SARS-CoV-2 Infected) Coronavirus disease 19 infection azvudine alone Nucleoside reverse transcriptase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HRH Holdings Limited GALZU INSTITUTE OF RESEARCH, SANTA CASA DE MISERICORDIA DE CAMPOS HOSPITAL (SCMCH), Universidade Estadual Do Norte Fluminense Darcy Ribeiro Brazil 2020-12-31 2021-06-30 IGZ-1, NCT04668235 Phase 3 Clinical Not yet recruiting 1 6 Months 342 Cleber G Silva, MD, MSc, George JM Mota, pharmacist, Paula GA Cabral, MSc, PhD, Renato S Martins, MSc, PhD 2020-12-19
Evaluation of Sedation in COVID-19 ARDS Coronavirus disease 19 infection, Respiratory distress syndrome Intubation alone, Mechanical ventilation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Johann Wolfgang Goethe-Universitat Frankfurt am Main Germany 2020-03-01 2021-01-01 #20-643 -SED II, NCT04667936 Phase Not Applicable Recruiting 1 10 Months 100 Armin N Flinspach, MD, Elisabeth H Adam, MD, Elisabeth H. Adam 2020-12-17
Effect of Liver Injury on Mortality in Coronavirus Disease-2019 Patients Admitted to Intensive Care Unit Coronavirus disease 19 infection, Liver injury liver function test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital Turkey 2020-04-01 2020-12-14 CKKACAR, NCT04669509 Phase Not Applicable Completed 1 8 Months 532 Cem Kıvılcım Kacar 2020-12-18
A clinical study to assess rabeximod for the potential treatment of Covid-19, rheumatoid arthritis and potential other indications Coronavirus disease 19 infection, Rheumatoid arthritis rabeximod alone Cyxone AB US Phase Not Applicable Planned 1 2020-12-17
An observational COVID-19 immune response study Coronavirus disease 19 infection 10x Genomics Inc, Adaptive Biotechnologies Corp, Bloodworks Northwest, Fred Hutchinson Cancer Research Center, Gilead Sciences Inc, Isoplexis Corp, Merck & Co Inc, Metabolon Inc, NanoString, Olink Bioscience, Scisco Genetics Inc, Stanford University Amazon Web Services, Biomedical Advanced Research and Development Authority (BARDA), M.J. Murdock Charitable Trust, National Institutes of Health, Novartis AG, Omeros Corp, Parker Institute for Cancer Immunotherapy, US Department of Defense Sweden Phase Not Applicable Status not specified 1 139 Dr Jason Goldman, Dr Yapeng Su 2020-12-17
IMMUNOMARKCOV: Predictive Immune Biomarkers of COVID-19 Pathogenesis to Influence Therapeutic Management Coronavirus disease 19 infection Blood collection alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-05-05 2021-12-31 IMMUNOMARKCOV, NCT04668170, RC31/20/0187 Phase Not Applicable Recruiting 2 19 Months 340 Guillaume Martin-Blondel, MD PhD, Isabelle PELLEGRIN, MD, Pierre DELOBEL, MD PhD, Pierre Delobel, MD PhD, Pierre Delobel, PU-PH 2020-12-17
Stop Covid 2: Fluvoxamine for Early Treatment of Covid-19: a Fully-remote, Randomized, Placebo-Controlled Trial Coronavirus disease 19 infection fluvoxamine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over), African Ancestry, European Ancestry, Native American Ancestry Washington University School of Medicine, COVID-19 Early Treatment Fund US, Canada 2020-12-31 2021-09-30 202011101, NCT04668950, Stop Covid 2 Phase 3 Clinical Not yet recruiting 5 9 Months 1100 Angela Stevens, Eric Lenze, MD 2020-12-18
Presence of antibodies in children and young adults living with at least one SARS-CoV-2 positive person Coronavirus disease 19 infection Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) University of Milano-Bicocca Universita degli Studi di Milano Italy 2020-03-15 2020-08-06 CE15052020, ISRCTN91064601 Phase Not Applicable Completed 2 4 Months 49 Prof Tartaglia 2020-12-19
Consequences of the COVID-19 Lockdown Measures on the CHRU Nancy Pediatric Emergency Services Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Central Hospital, Nancy, France France 2020-03-18 2020-06-30 2020PI235, NCT04668937 Phase Not Applicable Completed 1 3 Months 11000 BELIN Delphine 2020-12-18
Study to Investigate the Treatment Effect of Colchicine in Patients With COVID-19 Coronavirus disease 19 infection colchicine alone, standard COVID-19 care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ayub Teaching Hospital Universidad De Murcia Pakistan 2020-12-10 2021-07-09 ATH/IRB/COLCHICINE/25.11.2020, NCT04667780 Phase 3 Clinical Recruiting 1 7 Months 102 Dr Umer Farooq, Dr. Zeeshan Haroon, MBBS 2020-12-19
CATCOVID-AIR: Noninvasive Respiratory Support in COVID-19 Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia Noninvasive ventilation treatment alone, continuous positive airway pressure (CPAP) therapy alone, high-flow nasal cannula oxygen therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Vall D'Hebron Barcelona Institute for Global Health Spain 2020-05-22 2021-01-31 CATCOVID-AIR, NCT04668196, PR(AG)265/2020 Phase Not Applicable Recruiting 10 8 Months 300 Ana Cordoba, MD PhD, Antoni Marin Muñiz, MD, Gladis Sabater, MD, Juana Martinez Llorens, Md, PhD, Julia Tarrega, MD, Júlia Sampol, MD, Lourdes Lozano, MD, Manel Lujan, MD PhD, Mercedes Pallero, MD PhD, Oscar Bernadich, MD, Patricia Peñacoba, MD, Sergi Marti, MD PhD 2020-12-17
Moving On Trial: COVID-19 and homelessness Coronavirus disease 19 infection permanent housing alone Cardiff University United Kingdom Research & Innovation UK 2020-08-01 2022-01-06 CPMS 47728, ISRCTN69564614, Moving On Trial Phase Not Applicable Not yet recruiting 2 17 Months 1200 Miss Pell 2020-12-18
COVID-NIV: Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome Coronavirus disease 19 infection, Respiratory distress syndrome Capnography alone, Respiratory monitoring alone, electro impedance tomography alone, respiratory muscles ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) IM Sechenov Moscow Medical Academy Russian Federation 2020-10-01 2021-06-30 002-NIV-COVID, COVID-NIV, NCT04667923 Phase Not Applicable Recruiting 1 9 Months 50 Andrey I Yaroshetskiy, MD, PhD, ScD, Mikhail E Politov, MD, PhD, Sergey N Avdeev, MD, PhD, ScD 2020-12-18
CARP: COVID-19 Advanced Respiratory Physiology (CARP) Study Coronavirus disease 19 infection, Respiratory failure NHS Greater Glasgow and Clyde Altair Medical Ltd, Storm ID UK 2020-09-29 2021-09-29 CARP, INGN20RM136, NCT04668313 Phase Not Applicable Recruiting 1 12 Months 150 Chris Carlin, Jacqueline Anderson 2020-12-18
Pandemic-adapted Caries Care Multicenter Case-Series Coronavirus disease 19 infection, Dental caries modified cariescare international management alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs) Universidad El Bosque, Bogotá King's College London, University of Leeds, University of Sheffield Netherlands, Argentina, UK, Peru, US, Portugal, Uruguay, Colombia, Russian Federation, Brazil, France, Mexico, Dominican Republic 2020-11-15 2022-03-02 IRB00010617, NCT04666597 Phase Not Applicable Recruiting 21 15 Months 420 Aldo Squassi, PhD, Andrea Cortes, PhD, Andrea Ferreira Zandona, PhD, Angeles Martinez-Mier, PhD, Beatriz Echeverry, Christopher Deery, PhD, Clarisa Bonifacio, PhD, Fabiana Carletto-Körber, Irina Kusmina, PhD, Jesús R Osorio, Johanna Sanjuán, Juan S Lara, PhD, Ketty Ramos, Magdalena Sanmartin, Mariana M Braga, PhD, María DP Cerezo, Michele Muller Bolla, Ninoska Abreu-Placeres, Patricia Castro, Paulo Melo, PhD, Rita Villena, PhD, Stefania Martignon, PhD 2020-12-19
Efficacy and Safety of Ivermectin for Treatment and Prophylaxis of COVID-19 Pandemic Coronavirus disease 19 infection anticoagulation therapy alone, eyes, nose and mouth contact avoidance alone, hand hygiene maintenance alone, ivermectin alone, mask usage alone, personal protective equipment alone, respiratory etiquette alone, self-isolation alone, social distancing measures alone, steroid therapy alone, Variable regimens including acetylcystein , azithromycin , ivermectin , lactoferrin , paracetamol , vitamin C , zinc Chloride channel modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Benha University Egypt 2020-06-08 2020-10-30 NCT04668469, RE96.2020 Phase 2 Clinical Completed 1 4 Months 600 Ahmed G Elgazzar, M.D. 2020-12-17
Study of Coagulation Profile and Role of Heparin-Like Effect in Patients With COVID-19 Blood clotting disorder, Coronavirus disease 19 infection, Respiratory distress syndrome, Sepsis Sonoclot machine alone, whole blood coagulation test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Postgraduate Institute of Medical Education and Research India 2020-08-24 2021-02-01 IEC-04/2020-1641, NCT04668404 Phase Not Applicable Recruiting 1 5 Months 50 KAMAL KAJAL, KAMAL KAJAL, MD, Kamal KAJAL, MD, MADHUMITA PREMKUMAR, DM 2020-12-17
NOVATION-1: Phase III Inhaled Novaferon Study in Hospitalized Patients With Moderate to Severe COVID-19 Coronavirus disease 19 infection Novaferon alone, Standard of Care alone Interferon alpha 2 ligand Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Genova Inc 2021-01-31 2021-08-31 JH-COR-003, NCT04669015, NOVATION-1 Phase 3 Clinical Not yet recruiting 0 7 Months 914 Dimitri Fitsialos 2020-12-19
RESICOV: Hospital Interns Psychological State During the COVID-19 Coronavirus disease 19 infection, Psychiatric disorder Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-12-01 2021-07-30 NCT04669054, RECHMPL20_0665, RESICOV Phase Not Applicable No longer recruiting 1 7 Months 102 Emilie Olie, MD PhD 2020-12-17
Changing Susceptible Body Constitution for COVID-19 Prevention by Chinese Medicine in Hong Kong Residents Coronavirus disease 19 infection Variable regimens including Liu-Wei-Di-Huang (PuraPharm International) , Xiang-Sha-Liu-Jun (PuraPharm International) , Yu-Ping-Feng (PuraPharm International) Healthy volunteers accepted, Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of Hong Kong Hong Kong 2020-12-15 2022-11-30 NCT04668222, UW20-480 Phase 1/Phase 2 Clinical Not yet recruiting 1 23 Months 480 Cheng Zhang, Mphil, Van Szeto, Yibin Feng, PhD 2020-12-17
ORACLE: Oral Health, Microbial Burden and COVID-19 Coronavirus disease 19 infection PCR test alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Eastman Dental Insitute DermBiont Inc, The University College London Hospitals NHS Trust, The Whittington Hospital NHS Trust, University College London UK 2020-12-13 2021-12-12 283766, EDGE 132868, NCT04668911, ORACLE Phase Not Applicable Not yet recruiting 1 12 Months 150 Francesco D'Aiuto, DMD, PhD, MClinDent, Jeanie Suvan, Prof Francesco D'Aiuto 2020-12-19
A Trial Evaluating the Safety and Effects of an RNA Vaccine ARCT-021 in Healthy Adults Coronavirus disease 19 infection ARCT-021 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Arcturus Therapeutics Inc 2020-12-27 2022-04-30 ARCT-021-04, NCT04668339 Phase 2 Clinical Not yet recruiting 0 16 Months 600 Arcturus Therapeutics 2020-12-19
A 6-month research project to investigate the therapeutic potential of SDC-1801 in severe phase Covid-19 Coronavirus disease 19 infection SDC-1801 alone Jak1 tyrosine kinase inhibitor, Non receptor tyrosine kinase TYK2 antagonist Sareum Holdings plc United Kingdom Research & Innovation Phase Not Applicable Status not specified 0 2020-12-18
DIScOVER: Change in Disability in Activities of Daily Living Over Time Among Adults With Advanced Respiratory Disease During the COVID-19 Pandemic Chronic obstructive pulmonary disease, Coronavirus disease 19 infection, Interstitial lung disease, Metastatic lung cancer, Respiratory disease, Respiratory failure Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kings College Hospital NHS Trust National Institute for Health Research (NIHR) UK 2020-01-01 2021-08-01 DIScOVER, IRAS 271894, ISRCTN14159936 Phase Not Applicable Recruiting 6 19 Months 120 Miss Fettes 2020-12-19
AFTER: Predictors of Recovery and the App-Facilitated Tele-Rehabilitation (AFTER) Program for COVID-19 Survivors Coronavirus disease 19 infection biobehavioral tele-rehabilitation alone, home exercise alone, remote controlled exercise alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Colorado at Denver and Health Sciences Center US 2020-12-15 2021-08-01 20-2415, AFTER, NCT04663945 Phase Not Applicable Not yet recruiting 1 7 Months 45 Jennifer Stevens-Lapsley, MPT, PhD 2020-12-18
Evaluating Dove Confident Me Single Session In Indonesia Coronavirus disease 19 infection Dove confident me Indonesia single session program alone Healthy volunteers accepted, Children (6-12 yrs), Adolescents (13-17 yrs) University of the West of England Bristol Unilever, United Nations International Children's Fund, University of Hawaii, University of Indonesia UK 2021-01-31 2021-04-30 DSEP_UNICEF_INDO, HAS-HSS-18-098, NCT04665557 Phase Not Applicable Not yet recruiting 1 3 Months 2000 Nadia Craddock, EdM 2020-12-19
Phase I clinical trial of an inactivated COVID-19 vaccine (Shifa-Pharmed) in healthy individuals Coronavirus disease 19 infection inactivated COVID-19 vaccine (Shifa Pharmed Industrial Group Co) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Shifa Pharmed Industrial Group Co Iran 2020-12-21 IR.NREC.1399.003, IRCT20201202049567N1 Phase 1 Clinical Not yet recruiting 2 56 Minoo Mohraz, Minoo Mohraz- Mohamadreza Salehi- Payam Tabarsi, Mohammadreza Hosseinpour 2020-12-19
Effect of Interferon beta-1b on COVID-19 patients Coronavirus disease 19 infection interferon beta-1b alone, routine treatment alone Bandare-abbas University of Medical Sciences Iran 2020-10-22 IR.HUMS.REC.1399.259, IRCT20201001048894N1 Phase 2/Phase 3 Clinical Recruiting 1 90 Afshin Samiei, Dr.Negahi, Teymour Aghamolaei 2020-12-17
Investigational Performance Evaluation of the Nanomix eLab COVID-19 Rapid Antigen Panel With Samples From COVID-19 Positive and Negative Human Subjects Coronavirus disease 19 infection Nanomix eLab system alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nanomix Inc US 2020-12-01 2021-03-31 NCT04667442 Phase Not Applicable Recruiting 1 4 Months 60 David Ludvigson, Tina Landess 2020-12-19
Awake Pronation for Covid-19 Treatment Coronavirus disease 19 infection, Respiratory failure oxygenation via Venturi mask alone, prone position alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Ospedaliera Universitaria di Bologna Policlinico Azienda Unita Sanitaria Locale di Reggio Emilia, Hospital Bolzano, University Hospital, Modena Italy 2020-12-30 2021-07-01 1117/2020/SPER/AOUBO, NCT04667286 Phase Not Applicable Not yet recruiting 1 6 Months 100 stefano nava, stefano nava, MD 2020-12-18
Adapting Anxiety Intervention for Youth With Autism for Rapid Response to COVID-19 Anxiety disorder, Autism, Coronavirus disease 19 infection facing your fears program alone Children (6-12 yrs), Adolescents (13-17 yrs) Holland Bloorview Kids Rehabilitation Hospital Canada 2020-12-04 2021-11-30 0240, NCT04666493 Phase Not Applicable Recruiting 1 11 Months 100 Evdokia Anagnostou, MD, Kristina Hyunjee Lee, M.Ed 2020-12-19
An observational retrospective study on the role of methylprednisolone in preventing disease progression for hospitalized patients with severe COVID-19 Coronavirus disease 19 infection methylprednisolone alone Wuhan University China Phase Not Applicable Status not specified 1 175 2020-12-16
Personal Protective Equipment for the Prevention of SARS-Cov-2 During Neonatal Resuscitation Coronavirus disease 19 infection neonatal resuscitation alone, personal protective equipment alone University Hospital Padova Italy 2021-01-31 2021-03-31 COVID-NEO-RES-01, NCT04666233 Phase Not Applicable Not yet recruiting 1 2 Months 48 Daniele Trevisanuto 2020-12-18
Assessment of psychological outcomes in cancer patients during COVID-19 pandemic Acute stress disorder, Anxiety disorder, Cancer, Coronavirus disease 19 infection, Depression Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tata Memorial Center, Tata Memorial Hospital & Cancer Research Inst India 2020-12-22 CTRI/2020/12/029812 Phase Not Applicable Not yet recruiting 1 500 Dr J P Agarwal 2020-12-18
Evaluating efficacy and safety of goggles with or without inbuilt fan in health care workers inside COVID-ICU Coronavirus disease 19 infection N-95 mask alone, gloves alone, head gear alone, impermeable gown alone, indigenous fan powered goggles alone, shoe cover alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) All India Institute of Medical Sciences India 2020-12-24 CTRI/2020/12/029805 Phase Not Applicable Not yet recruiting 1 30 Dr Navdeep Sokhal 2020-12-18
MoveStrong at Home Arthritis, Cardiovascular disease, Congestive heart failure, Coronavirus disease 19 infection, Diabetes mellitus, Hypertension, Lung disease, Obesity, Osteoporosis, Renal disease, Skin cancer, Stroke Exercise program alone, MoveStrong alone, Nutrition education alone, Physitrack alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Waterloo Canada 2020-10-05 2021-04-01 42206, NCT04663685 Phase Not Applicable Recruiting 1 5 Months 25 Ellen Wang, BSc, Lora Giangregorio, PhD 2020-12-19
O-ACEPOP: Online Culture for Mental Health in People Aged 16 to 24 Anxiety disorder, Coronavirus disease 19 infection, Depression Ashmolean Website alone, Ways of Being online Experience alone Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs) University of Oxford 2020-12-04 2021-03-31 0009275, NCT04663594, O-ACEPOP Phase Not Applicable Not yet recruiting 0 3 Months 400 Evgenia Riga, Rebecca Sheriff, PhD 2020-12-16
COVIAS: Evaluation of SARS-CoV2-specific serum parameters in blood samples of SARS-CoV2-seronegative healthy volunteers, hospitalized SARS-CoV2-patients with acute disease and recovered SARS-CoV2-patients with asymptomatic/mild/severe disease Coronavirus disease 19 infection blood drawing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Heidelberg ImmunoTherapeutics GmbH Germany 2020-12-20 COVIAS, DRKS00023877, S-719/2020 Phase Not Applicable Not yet recruiting 1 150 Torsten Schaller 2020-12-18
TB TRIAGE+ Accuracy: Diagnostic Accuracy of CAD4TB and C-reactive Protein Assay as Triage Tests for Pulmonary Tuberculosis Coronavirus disease 19 infection, HIV infection, Mycobacterium tuberculosis infection Afinion AS100 analyzer (Alere Afinion) alone, Afinion C-reactive protein assay alone, Alere Determine TB LAM Ag test alone, CAD4COVID software (Delft Imaging System) alone, CAD4TB software version 6 and 7 (Delft Imaging System) alone, CD4 advanced disease test alone, CrAg lateral flow assay alone, SARS-COV-2 antigen rapid diagnostic test alone, SARS-COV-2 real-time PCR alone, Standard Q COVID-19 Ag rapid chromatographic immunoassay alone, Standard Q COVID-19 Ag testing device (SD biosensor) alone, Visitect CD4 advanced disease testing device (Omega Diagnostics) alone, Xpert MTB/RIF Ultra assay alone, Xpert MTB/RIF assay alone, differential white blood cell count test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Swiss Tropical & Public Health Institute Charite University, European and Developing Countries Clinical Trials Partnership, Foundation for Innovative New Diagnostics, Human Sciences Research Council, Institute of Tropical Medicine, Ministry of Health of Lesotho, Radboud University, SolidarMed, University Hospital Basel Lesotho, South Africa 2020-12-31 2022-05-31 NCT04666311, P1685-20A, TB TRIAGE+ Accuracy Phase Not Applicable Not yet recruiting 2 17 Months 1400 Aita Signorell, PhD, Klaus Reither, MD, PhD 2020-12-18
MACH19: Mushroom-based Product for COVID-19 Coronavirus disease 19 infection Fomitopsis officinalis and Trametes versicolor intake alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of California San Diego University of California Irvine, University of California Los Angeles US 2020-12-03 2021-08-01 200633, MACH19, NCT04667247 Phase 1/Phase 2 Clinical Recruiting 2 7 Months 66 Andrew Shubov, MD, Gordon Saxe, MD, Lauray MacElhern, MBA, Tatyana Shekhtman, MS 2020-12-16
Wü-KiTa-CoV: Würzburg Childcare Study during the COVID-19 pandemic: A study into the acceptance of different screening measures for the detection of infections with the novel coronavirus (SARS-CoV-2) in child daycare centers in Würzburg Coronavirus disease 19 infection Nasal swabs alone, Throat swabs alone, saliva samples alone University of Wurzburg Bundesministerium für Bildung und Forschung Germany 2020-10-01 182/20-me, DRKS00023721, Wü-KiTa-CoV, http://doi.org/10.23728/b2share.0ee3419f9ed84d17a048bd5ab18c040a Phase Not Applicable Recruiting 1 1000 Oliver Kurzai, Studiensekretariat Wü-KiTa-CoV 2020-12-19
Changes in Viral Load in COVID-19 After Probiotics Coronavirus disease 19 infection Variable regimens including Bifidobacterium animalis , Bifidobacterium longum , Lactis rhamnosus , Lactobacillus rhamnosus , Vitamin D , seleniumt , zinc Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital de Sagunto Biopolis Sl, Laboratorios Heel España Spain 2020-04-01 2021-02-28 HDESAGUNTO, NCT04666116 Phase Not Applicable Recruiting 1 11 Months 96 Laura Sanchis, Xavier Cortes, Xavier Cortés, xavier cortés 2020-12-18
Oxygen therapy in covid positive patients Coronavirus disease 19 infection, Hypoxia, Respiratory failure high flow nasal oxygen cannula therapy alone, non invasive mechanical ventilatory support therapy alone, non rebreathing oxygen face mask therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sri Venkateswara Institute of Medical Sciences India 2020-12-25 CTRI/2020/12/029803 Phase Not Applicable Not yet recruiting 1 122 Aloka Samantaray, Bhargavi Thota 2020-12-18
REMM-HIIT-ICU-COVID: Remotely Monitored, Mobile Health Supported High Intensity Interval Training for Survivors of COVID-19 Coronavirus disease 19 infection remotely monitored, mhealth supported hgh intensity interval training alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Duke University US 2021-01-01 2023-02-01 NCT04664101, PRO00105798, REMM-HIIT-ICU-COVID Phase Not Applicable Not yet recruiting 1 25 Months 30 Alice Szydlowska, Alicja Szydlowska, Paul Wischmeyer, MD 2020-12-18
Ocular Findings and Viral Persistence in Ocular Fluids in COVID-19 Survivors, a Natural History, Observational Study Coronavirus disease 19 infection chloroquine alone, hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Eye Institute National Institutes of Health Clinical Center US 2020-12-22 2023-06-30 000078-EI, 10000078, NCT04665752 Phase Not Applicable Recruiting 1 30 Months 150 Dominic Obiyor, R.N., Hatice N Sen, M.D. 2020-12-19
SWS-COVID-19: Southampton Women's Survey COVID-19 Study Coronavirus disease 19 infection Healthy volunteers accepted, Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University Of Southampton UK 2020-12-31 2020-12-31 56780, NCT04666285, SWS-COVID-19 Phase Not Applicable Not yet recruiting 1 1000 Keith Godfrey, BM, PhD,FRCP, Sarah Crozier 2020-12-17
Viral Shedding, Symptoms and Exposure of SARS-CoV-2 in Non-hospitalized Children With COVID-19 Coronavirus disease 19 infection reverse transcription-polymerase chain reaction alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Rigshospitalet Denmark 2020-05-25 2021-06-30 H-20028631-1, NCT04666207 Phase Not Applicable Recruiting 1 13 Months 20 Allan Bybeck Nielsen, Marie-Louise von Linstow, MD, PhD, Ulrikka Nygaard, MD, Ulrikka Nygaard, MD, PhD 2020-12-18
The use of tocilizumab in patients with severe COVID19 pneumonia - a trial to know its efficacy in those on steroids Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure, Viral pneumonia conventional treatment alone, tocilizumab alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nehru HOSPITAL, Postgraduate Institute of Medical Education and Research India 2020-12-31 CTRI/2020/12/029793 Phase 3 Clinical Not yet recruiting 1 54 Naveen Naik B 2020-12-18
Treatment of COVID-19 sequelae with physical exercises Coronavirus disease 19 infection Breathing exercises alone, bronchial hygiene techniques alone, respiratory rehabilitation alone Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq, Fundação de Amparo à Pesquisa e a Inovação do Estado de Santa Catarina Brazil 2020-03-11 2021-01-11 38682820.0.0000.0121, 4.377.082, RBR-5p8nzk6, U1111-1261-4925 Phase 1 Clinical Recruiting 1 10 Months 82 Aderbal Silva Aguiar 2020-12-18
Comparison of two drugs for better treatment of covid-19 related lung problems Coronavirus disease 19 infection, Pulmonary fibrosis, Viral pneumonia nintedanib alone CSF-1 antagonist, FGF receptor antagonist, FGF1 receptor antagonist, FGF2 receptor antagonist, FGF3 receptor antagonist, Flt3 tyrosine kinase inhibitor, Lck tyrosine kinase inhibitor, Lyn tyrosine kinase inhibitor, PDGF receptor alpha antagonist, PDGF receptor antagonist, PDGF receptor beta antagonist, Src tyrosine kinase inhibitor, VEGF receptor antagonist, VEGF-1 receptor antagonist, VEGF-2 receptor antagonist, VEGF-3 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) KIIT University, Kalinga Institute of Medical Sciences India 2020-12-16 CTRI/2020/12/029814 Phase 2 Clinical Not yet recruiting 1 30 Deepak Sahoo, Pratima Singh 2020-12-18
Symptom-Based Markers for COVID-19 Transmission Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Iowa US 2020-12-31 2021-04-30 202007450, NCT04665245 Phase Not Applicable Not yet recruiting 1 4 Months 500 Alberto M Segre, PhD, Shelby L Francis, PhD 2020-12-17
Access to Chiropractic Care During the COVID-19 Pandemic Coronavirus disease 19 infection, Pain Chiropractic care alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Real Escorial-Maria Cristina University Center Instituto de Investigación Sanitaria de la Fundacion Jimenez Diaz, The University of Birmingham, Universite du Quebec a Trois-Rivieres Spain 2020-12-14 2021-02-28 COHORTCHIROCOVID19, NCT04666779 Phase Not Applicable Not yet recruiting 1 2 Months 500 Arantxa Ortega de Mues, PhD, Carlos Gevers-Montoro, DC,MSc,PhD (c) 2020-12-18
REMED: Effect of Two Different Doses of Dexamethasone in Patients With ARDS and COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome corticosteroid therapy alone, dexamethasone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Brno Charles University, Faculty Hospital Kralovske Vinohrady, Masaryk Hospital Czech Republic 2021-01-01 2023-03-31 CZECRIN NO. 2020/47, NCT04663555, REMED Phase 4 Clinical Not yet recruiting 1 27 Months 300 Jan Malaska,, Jan Maláska, MD, PhD, EDIC, Jan Stašek, MD, EDIC, Jan Stašek, MD, PhD, EDIC 2020-12-16
COVILUS2: Validation of COVILUS Score in Patients Suspected of COVID-19 Infection in the Emergency Room Coronavirus disease 19 infection SARS-CoV-2 RT-PCR test alone, lung ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens France 2020-12-10 2021-07-31 COVILUS2, NCT04666064, PI2020-843-0129 Phase Not Applicable Recruiting 1 7 Months 100 Stéphane Bar, Dr, Stéphane Bar, MD 2020-12-16
PERSIA: Inspiratory Effort in COVID-19 Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia non invasive respiratory support alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Modena and Reggio Emilia Italy 2020-03-01 2022-02-01 NCT04666246, PERSIA, UMODENAREGGIO17 Phase Not Applicable Recruiting 1 23 Months 40 Alessandro Marchioni, MD, Roberto Tonelli, MD 2020-12-17
A Study to Assess the Virological Efficacy of REGN-10933 + REGN-10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 Infection Coronavirus disease 19 infection casirivimab + imdevimab (COVID-19), Regeneron/Roche/Genentech alone COVID19 Spike glycoprotein inhibitor Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Regeneron Pharmaceuticals Inc US 2020-12-15 2021-04-24 NCT04666441, R10933-10987-COV-20145 Phase 2 Clinical Not yet recruiting 3 4 Months 1400 Clinical Trial Management, Clinical Trials Administrator 2020-12-19
Effect of malaria or dengue in COVID-19 patients Coronavirus disease 19 infection, Dengue virus infection, Plasmodium infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) B.Y.L Nair Charitable Hospital India 2020-12-21 CTRI/2020/12/029772 Phase Not Applicable Not yet recruiting 1 200 Dr Niraj Mahajan 2020-12-17
Ibrutinib for the Treatment of Patients With B-Cell Malignancies Who Are Infected With Coronavirus Disease 2019 (COVID-19) Chronic lymphocytic leukemia, Coronavirus disease 19 infection, Lymphoplasmacytic lymphoma, Mantle cell lymphoma, Marginal zone B-cell lymphoma ibrutinib alone Btk tyrosine kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Academic and Community Cancer Research United National Cancer Institute US 2020-12-31 2025-05-01 ACCRU-LY-2001, NCI-2020-11785, NCT04665115, P30CA015083 Phase 2 Clinical Not yet recruiting 1 52 Months 134 ACCRU Operations, Sameer A Parikh, Sameer A. Parikh 2020-12-16
What happens when a patient having connective tissue disease develops COVID-19 infection? Connective tissue disease, Coronavirus disease 19 infection, Interstitial lung disease Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) KIIT University, Kalinga Institute of Medical Sciences India 2020-12-12 CTRI/2020/12/029761 Phase Not Applicable Not yet recruiting 1 30 Pratima Singh 2020-12-17
SARS-CoV-2 Donor-Recipient Immunity Transfer Acute lymphoblastic leukemia, Acute myelogenous leukemia, Chronic lymphocytic leukemia, Chronic myelocytic leukemia, Coronavirus disease 19 infection, Hodgkins disease, Myelodysplastic syndrome, Myelofibrosis, Myeloproliferative disorder, Non-Hodgkin lymphoma biomarker analysis alone, granulocyte-colony stimulating factor plus hematopoietic stem cell transplant Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) City of Hope Medical Center National Cancer Institute US 2020-09-23 2022-09-23 20153, NCI-2020-11156, NCT04666025, P30CA033572 Phase 2 Clinical Recruiting 1 24 Months 36 Monzr M Al Malki, Monzr M. Al Malki 2020-12-17
Retrospective Study of ImmunoFormulation for COVID-19 Coronavirus disease 19 infection Variable regimens including Imuno TF , Miodesin , N-acetylcysteine , SiliciuMax , ascorbic acid , cholecalciferol , ferulic acid , glucosamine sulphate + potassium chloride , resveratrol , selenium yeast , spirulina , zinc orotate Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fagron Iberica S.A.U. Spain 2020-07-02 2020-09-29 IMUNO TF STUDY, NCT04666753 Phase Not Applicable Completed 2 2 Months 40 Hudson Polonini, PhD 2020-12-16
IC-COVID-19: Infection Control for Severe Acute Respiratory Syndrome Coronavirus 2 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) NMC Specialty Hospital United Arab Emirates 2021-01-15 2021-02-28 IC-COVID-19, NCT04665960, NMCSPECIALTYH Phase Not Applicable Not yet recruiting 1 1 Month 40 Prashant Nasa, Prashant Nasa, MD FNB, Sheila Myatra, MD 2020-12-19
Exploratory study of safety and efficacy of functional foods containing 5-aminolevulinic acid phosphate and iron for COVID-19 Coronavirus disease 19 infection 5-aminolevulinic acid phosphate alone, iron alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Neopharma Japan Co, Ltd Japan 2020-10-29 jRCTs071200048 Phase 2 Clinical Recruiting 1 50 Koichi Izumikawa, Takeyuki Tanaka 2020-12-17
Teprenone for preventing aggravation of COVID-19 Coronavirus disease 19 infection teprenone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Okayama University Hospital Japan 2020-05-20 jRCTs061200002 Phase 2 Clinical Recruiting 1 100 ICHIHARA Eiki 2020-12-17
Specified clinical trial for ECMO system for COVID-19 resipiratory failure Coronavirus disease 19 infection novel extracorporeal membrane oxygenation (ECMO) system alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japan Agency for Medical Research and Development Japan 2020-09-07 jRCTs052200053 Phase 2 Clinical Recruiting 1 50 Fukushima Norihide 2020-12-16
Prohylaxis with hydroxichloroquine aiming at prevention of COVID-19 for medical care workers Coronavirus disease 19 infection hydroxychloroquine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Public Corp Osaka Japan 2020-09-25 jRCTs051200060 Phase 3 Clinical Not yet recruiting 1 500 Kakeya Hiroshi, Kaneko Akira 2020-12-17
COVID-19 Vaccine and Impact on Fertility Study Coronavirus disease 19 infection, Male infertility COVID19 vaccine alone Healthy volunteers accepted, Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University of Miami US 2020-12-14 2021-06-14 20201451, NCT04665258 Phase Not Applicable Recruiting 1 6 Months 60 Manuel Molina, MD, Ranjith Ramasamy, MD, manuel molina, md 2020-12-16
Biochem, hemato, covid-19, prognostic marker Coronavirus disease 19 infection Hospital Sungai Buloh Malaysia 2020-12-14 2021-12-14 57002, NMRR-20-2682-57002 Phase Not Applicable Status not specified 6 12 Months Dr Alia Nasriana binti Nasuruddin, Dr Dian Nasriana Nasuruddin, Dr JANNALTUL ADNI BINTI AZMI, Dr Nadiah Binti Mohamed Zainuddin, Dr TING HUONG YEW, Dr Tharmini Ravi, Sharifah Khairul Atikah 2020-12-16
COVID-19 Vaccine Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Selayang Hospital Malaysia 2021-01-01 2021-03-01 57541, NMRR-20-2674-57541 Phase Not Applicable Not yet recruiting 1 2 Months Dr NORLIZA MAT ARIFFIN 2020-12-16
A phase II/III, randomized, double-blind, controlled clinical trial of recombinant bivalent second-generation adenovirus (hAd5) vector-delivered SARS-CoV-2 S + N protein vaccine (subcutaneous, COVID-19), ImmunityBio for the treatment of patients infected with SARS-CoV-2 Coronavirus disease 19 infection recombinant bivalent second-generation adenovirus (hAd5) vector-delivered SARS-CoV-2 S + N protein vaccine (subcutaneous, COVID-19), ImmunityBio alone COVID19 Spike glycoprotein modulator, COVID19 nucleoprotein modulator ImmunityBio Inc 2020-08-31 Phase 2/Phase 3 Clinical Recruiting 0 2020-12-15
Effect of biotin, brewer's yeast and vitamin C supplements in patients with COVID-19 Coronavirus disease 19 infection routine therapy alone, Variable regimens including biotin , brewer's yeast , vitamin C Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Tehran University of Medical Sciences Iran 2020-10-15 IR.TUMS.MEDICINE.REC.1399.574, IRCT20201004048923N1 Phase 3 Clinical Recruiting 1 50 Dr Maliheh Paknejad, ِDr Maliheh Paknejad 2020-12-16
Wide Scale Monitoring for Acute Respiratory Infection Using a Mobile-Based Study Platform Coronavirus disease 19 infection, Influenza virus infection, Respiratory tract infection mobile based platform app (Google Inc) alone, wide scale monitoring alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Boston Children's Hospital Google Inc US 2020-11-04 2021-12-08 NCT04663776, P00036213 Phase Not Applicable Recruiting 1 13 Months 100000 John Brownstein, PhD 2020-12-17
3PU-SSE: Prediction of the Patient Pathway in Emergency Room in an Exceptional Sanitary Situation Coronavirus disease 19 infection 3P-U application alone, hospital bedroom booking alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire D Amiens France 2020-12-04 2021-03-31 3PU-SSE, NCT04665778, PI2020-843-0055 Phase Not Applicable Recruiting 1 3 Months 1516 Emilien Arnaud, MD, Émilien ARNAUD, MD 2020-12-15
The Effect of Diabetes Mellitus on Mortality of Patients With COVID-19 Coronavirus disease 19 infection, Diabetes mellitus, Viral pneumonia Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Etfal Hospital Turkey 2020-03-15 2020-05-15 1559, NCT04663659 Phase Not Applicable Completed 1 2 Months 150 Nermin Balta Basi 2020-12-16
A retrospective study of prevalence of incidental pneumonia consistent with COVID19 infection an 18F-Fcholine (FCH) PET/CT in patients referred for prostate cancer Coronavirus disease 19 infection, Prostate tumor 18F-choline alone, computed tomography alone, positron emission tomography alone Hopital Tenon France Phase Not Applicable Status not specified 1 96 2020-12-15
Mental Health Status Mong Admitted Antepartum and Postpartum Women during the COVID-19 Pandemic at the isolation facility in a Tertiary Hospital Coronavirus disease 19 infection, Psychiatric disorder Southern Philippines Medical Center Philippines 2020-12-17 2021-01-17 PHRR201214-003202 Phase Not Applicable Not yet recruiting 1 1 Month Cherie Anne V. Songcaya 2020-12-17
A Study of Clinical Manifestations of Patients with Pulmonary Abnormalities in 18FDG-PET with COVID-19 Infection Coronavirus disease 19 infection computed tomography alone, fludeoxyglucose (18F) alone, positron emission tomography alone University of Gregorio Maranon Phase Not Applicable Status not specified 0 19 2020-12-15
Dyn3CEA_Nosocor: COVID-19 - SARS-CoV-2 Community Contamination in Children and Adults Coronavirus disease 19 infection Hospices Civils De Lyon 2021-01-01 2021-04-04 69HCL20_1100, Dyn3CEA_Nosocor, NCT04664296 Phase Not Applicable Not yet recruiting 0 3 Months 75 Dominique PLOIN, MD 2020-12-16
PREDICT-ILI: Predicting Severity and Disease Progression in Influenza-like Illness (Including COVID-19) Coronavirus disease 19 infection, Influenza virus infection, Respiratory tract infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Imperial College London UK 2020-12-07 2021-06-30 20SM6170, NCT04664075, PREDICT-ILI Phase Not Applicable Not yet recruiting 1 6 Months 100 Christopher Chiu, PhD, Emma Bergstrom, BSc 2020-12-18
Evaluating Safety, Pharmacokinetics and Clinical Benefit of Silmitasertib (CX-4945) in Subjects With Moderate COVID-19 Coronavirus disease 19 infection, Viral pneumonia best supportive care alone, silmitasertib alone Casein kinase II inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Senhwa Biosciences Inc Georgia, US 2020-12-03 2021-02-11 CX4945 AV01-IIT, NCT04663737 Phase 2 Clinical Recruiting 2 2 Months 20 Bella S.C. Bleza, MPH, Chris P. Recknor, MD, Tina Foreman 2020-12-16
To assess symptoms and quality of life in post COVID patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) GMERS Medical College and Hospital India 2020-12-25 CTRI/2020/12/029755 Phase Not Applicable Not yet recruiting 1 50 Dr Anand K Patel, Dr Khushboo Chahwala 2020-12-16
Mass Triaging of Covid 19 Coronavirus disease 19 infection mass triage technique alone HOSPITAL QUEEN ELIZABETH II Malaysia 2020-12-15 2021-01-15 57593, NMRR-20-2693-57593 Phase Not Applicable Recruiting 1 1 Month Dr Aehtoosham Bin Suleman 2020-12-19
Study of clinical and radiological presentation among COVID-19 hospitalized patients based on COVID swab tests Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sri Ramachandra Institute of Higher Education and Research, Sri Ramachandra University India 2020-12-28 CTRI/2020/12/029754 Phase Not Applicable Not yet recruiting 1 100 Dr SP Thiagarajan, Dr Swathy Moorthy 2020-12-16
Perceived emotional, Perceived stressors, Stress level, Coping strategies, Nurses, COVID 19 Pandemic Acute stress disorder, Coronavirus disease 19 infection Healthy volunteers accepted International Medical University Malaysia 2020-12-15 2021-03-31 57277, NMRR-20-2686-57277 Phase Not Applicable Not yet recruiting 1 3 Months Radha Maniam, THANNEESWARRY A/P PARANJOTHI 2020-12-17
Impact of Covid-19 NPI in Malaysia Coronavirus disease 19 infection Non-pharmaceutical Interventions (NPI) alone Universiti Sains Malaysia Malaysia 2021-01-17 2021-10-31 57292, NMRR-20-2684-57292 Phase Not Applicable Status not specified 1 9 Months Dr MOHD IZRUL ISHAM BIN ROSIDI 2020-12-16
Mental health impact of COVID-19 pandemic on PMNS cohort Coronavirus disease 19 infection, Psychiatric disorder Healthy volunteers accepted, Young Adults (18-44 yrs) KEM Hospital and Research Center India 2020-12-26 CTRI/2020/12/029780 Phase Not Applicable Not yet recruiting 1 370 Rishikesh V Behere 2020-12-16
Nintedanib therapy will improve management in covid 19 fibrosis if given early or not Coronavirus disease 19 infection, Pulmonary fibrosis, Viral pneumonia nintedanib alone CSF-1 antagonist, FGF receptor antagonist, FGF1 receptor antagonist, FGF2 receptor antagonist, FGF3 receptor antagonist, Flt3 tyrosine kinase inhibitor, Lck tyrosine kinase inhibitor, Lyn tyrosine kinase inhibitor, PDGF receptor alpha antagonist, PDGF receptor antagonist, PDGF receptor beta antagonist, Src tyrosine kinase inhibitor, VEGF receptor antagonist, VEGF-1 receptor antagonist, VEGF-2 receptor antagonist, VEGF-3 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) KIIT University, Kalinga Institute of Medical Sciences India 2020-12-14 CTRI/2020/12/029783 Phase 2 Clinical Not yet recruiting 1 30 Pratima Singh 2020-12-16
Establishment of a Indo-US Molecular Biomarker Knowledge Network for COVID-19 Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Indo-US Science and Technology Forum Amrita Institute of Medical Sciences India 2020-12-23 CTRI/2020/12/029773 Phase Not Applicable Not yet recruiting 1 100 Dr Shantikumar V Nair 2020-12-16
Oral Isotretinoin and Covid-19 Infection Coronavirus disease 19 infection isotretinoin alone Retinoic acid receptor agonist Healthy volunteers accepted, Adolescents (13-17 yrs), Young Adults (18-44 yrs) University of Aberdeen UK 2021-01-15 2021-05-31 1/095/20, NCT04663906 Phase Not Applicable Not yet recruiting 1 4 Months 300 Louise King 2020-12-16
An Approach to Screening for COVID-19 at Vancouver Airport Coronavirus disease 19 infection Panbio COVID-19 Ag Rapid Test Device (Abbott Rapid Diagnostics) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of British Columbia Providence Health & Services, Vancouver Airport Authority, WestJet Airlines Canada 2020-11-23 2021-04-30 H20-03225, NCT04665193 Phase Not Applicable Recruiting 1 5 Months 900 Don Sin, MD, Jonathan D'Cruz, Lynda Lazosky, Marc Romney, MD, Tony Yang, PhD 2020-12-16
Understanding Immunity to the COVID-19 Vaccines Coronavirus disease 19 infection COVID-19 vaccine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Stanford University National Institute of Allergy and Infectious Diseases US 2021-01-31 2023-01-31 5U19AI057229-17, IRB-59566, NCT04664309 Phase Not Applicable Not yet recruiting 1 24 Months 1000 Allie Lee, Kari Nadeau, MD, PhD 2020-12-16
The Outcomes of NRICM101 on SARS-COV-2 (COVID-19) Infection Coronavirus disease 19 infection NRICM101 (National Research Institute of Chinese Medicine) alone Healthy volunteers accepted National Research Institute of Chinese Medicine Taiwan 2020-12-20 2022-12-31 NCT04664049, NRICM101 Phase Not Applicable Not yet recruiting 1 24 Months 51000 Chien-Jung Lin, MD, PhD, Yi-Chang Su, MD, PhD 2020-12-16
BIOMARK-COVID: Description of Immunological, Enzymatic and Metabolic Biomarkers Associated to the Severity of COVID-19 (SARS-CoV-2) and Its Resolution Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire De Poitiers Etablissement D’Hospitalisation France 2020-12-09 2022-07-30 BIOMARK-COVID, BIOMARK-COVID, NCT04664023 Phase Not Applicable Recruiting 1 19 Months 120 Nicolas Lévêque, MD 2020-12-16
Efficacy and Safety of High-dose Vitamin C Combined With Chinese Medicine Against Coronavirus Pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Variable regimens including Baimu Qingre Jiedu , Buzhong Yiqi , Huhuang detoxicity paste , alpha-interferon , arbidol , folic acid , immunoglobulin C , ribavirin , vitamin C , vitamin E Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Xi'an International Medical Center Hospital China 2020-02-06 2021-01-31 NCT04664010, XIANINTERNATIONALMCH_HXJ Phase 2 Clinical No longer recruiting 1 11 Months 60 Guoyu Wang, Hui Gao, Jiayue Shan, Kuiwei Zhang, Lei Shang, Qiang Yi, Rui Wang, Shanjiao Jiang, Shenhao Liu, Xijing He, MD, Xudong Yang, Yali Wang, Yifan Feng, Yongping Liu, Zhijian Cheng 2020-12-16
Evaluation Of The Effect Of Favipiravir On Management Patient With Covid-19 Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Arak University of Medical Sciences and Health Services Iran 2020-11-21 IR.ARAKMU.REC.1399.179, IRCT20201028049175N1 Phase 3 Clinical Recruiting 2 114 Alireza Kamali, Behnam Mahmoudieh, Dr.Alireza Kamali, Hossein Sarmadian, Shamim Valibak 2020-12-17
Effects of COVID-19 on dialysis patients Coronavirus disease 19 infection, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidade Federal de Minas Gerais Associação Evangélica Beneficente de Minas Gerais Brazil 2020-05-01 3,991,721, 31017120.9.0000.8787, A06004831697, RBR-63hzd3 Phase Not Applicable Recruiting 1 2270 Gabriel Assis Lopes do Carmo 2020-12-16
A retrospective study to evaluate the effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU Coronavirus disease 19 infection remdesivir alone COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator Azienda Ospedali Riuniti Marche Nord Italy Phase Not Applicable Status not specified 1 51 2020-12-16
An observational study to evaluate nomacopan in particular COVID-19 patients subgroups Coronavirus disease 19 infection nomacopan alone Complement C5 factor inhibitor, Leukotriene BLT receptor antagonist Akari Therapeutics Plc UK Phase Not Applicable Planned 1 100 2020-12-14
Impact of nanopore platform on rapid diagnosis of COVID-19 in patients with respiratory tract infections Coronavirus disease 19 infection, Respiratory tract infection nanopore testing alone Osaka General Medical Center, Osaka University Japan 2020-12-14 2022-12-31 UMIN000042723 Phase Not Applicable Recruiting 1 24 Months 500 Jumpei Yoshimura, Tomoya Hirose 2020-12-16
An observational study evaluating the susceptibility of coronavirus infections in patients taking calcineurin inhibitors compared to non calcineurin inhibitors treatment patients Coronavirus disease 19 infection cyclosporine alone, tacrolimus alone Calcineurin inhibitor Pulsedata Inc US Phase Not Applicable Status not specified 1 5144 2020-12-14
A case-report study of a COVID-19 patient with rhabdomyolysis Coronavirus disease 19 infection, Renal injury, Rhabdomyolysis hemodialysis alone, sarilumab alone IL-6 receptor antagonist Female, African Ancestry University of Florida College of Medicine Phase Not Applicable Status not specified 0 1 2020-12-14
LIF-nCov-2019: A non-interventional, fully anonymized study for the comparative evaluation of a new direct detection methods for infection with SARS-CoV-2 (COVID-19) in clinical samples Coronavirus disease 19 infection, Respiratory disease RT-PCR alone, laser-induced fluorescence spectrospcopy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Aachen Deutsche Forschungsgemeinschaft (DFG), Deutsches Wollforschungsinstitut an der Rheinisch-Westfalischen Technischen Hochschule Aachen eV, German Federal Ministry of Education and Research Germany 2020-04-08 2020-04-30 DRKS00023821, EK 093/20, LIF-nCov-2019 Phase Not Applicable Completed 1 350 Mathias Hornef, Michael Kleines 2020-12-16
Has COVID-19 pandemic been affecting scientific trials to be done by students of Anesthesia Department? Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Postgraduate Institute of Medical Education and Research India 2020-12-20 CTRI/2020/12/029724 Phase Not Applicable Not yet recruiting 1 91 Gandhi Komal Anil 2020-12-18
A Study to Assess the Effectiveness of CAP Asmo in COVID-19 Positive Patients Coronavirus disease 19 infection Asmo capsule (RPS Biotech Private Limited) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) RPS BIOTECH PVT LTD India 2020-12-15 CTRI/2020/12/029714 Phase 2 Clinical Not yet recruiting 1 100 DR MANOJ RUNGHE 2020-12-18
RES-Q-HR: Reconvalescent plasma/Camostat mesylate early in Sars-CoV-2 Q-PCR positive high risk individuals Coronavirus disease 19 infection, Viral pneumonia camostat mesylate alone, convalescent plasma alone, dexamethasone alone, remdesivir alone COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator, Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Heinrich Heine Universitat Dusseldorf German Ministry of Health Germany 2020-12-02 2020-004695-18, RES-Q-HR, RES-Q-HR Phase 2 Clinical Recruiting 1 Clinic for Gastroenterology, Hepato 2020-12-19
Pilot, open-label, monocentric study evaluating safety and clinical effect of application of Normosang in patients with COVID-19 disease Coronavirus disease 19 infection, Respiratory disease heme arginate alone Hemoglobin synthesis stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Thomayerova Teaching Hospital Czech Republic 2020-11-16 2020-004682-39, KFJ-2020-02-NORMOSANG Phase 4 Clinical Recruiting 1 8 Skopek -trial coordinator 2020-12-19
COVIDOM: Long-term morbidity of SARS-CoV-2 infection and COVID-19 disease: consequences for health status and quality of life Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Charite Universitaetsmedizin Berlin Deutsche Forschungsgemeinschaft (DFG), German Federal Ministry of Education and Research, Nationales Pandemie Kohorten Netz Germany 2020-11-16 COVIDOM, D 537/20, DRKS00023742 Phase Not Applicable Recruiting 3 2000 Anne Hermes, Stefan Schreiber 2020-12-18
The effect of Hyssop and Verbascum herbal tea on clinical symptoms of Covid-19 Coronavirus disease 19 infection Hyssop herbal tea alone, Verbscum herbal tea alone, Variable regimens including Seroflo , ceftriaxone , dexamethasone , doxycycline hyclate , favipiravir , interferon beta-1a follow-on biologic (subcutaneous), CinnaGen , ipratropium bromide , levofloxacin , meropenem , methylprednisolone , salbutamol , tocilizumab Beta 2 adrenoceptor antagonist, DNA gyrase inhibitor, Interferon beta ligand, Muscarinic receptor antagonist, Penicillin binding protein inhibitor, RNA polymerase inhibitor, Topoisomerase IV inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Khomein Medical University Iran 2020-12-21 IR.KHOMEIN.REC.1399.012, IRCT20100130003227N15 Phase 2 Clinical Not yet recruiting 1 50 Ashraf Salehi, Dr Mojtaba Didedar, Hamid Moemeni, Mohammad Taheri 2020-12-17
A Study to Evaluate Clazakizumab in Patients With Life-threatening COVID-19 Infection Coronavirus disease 19 infection, Respiratory distress syndrome clazakizumab alone IL-6 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mayo Clinic Arizona US 2020-12-31 2020-12-31 20-008170, NCT04659772 Phase 2 Clinical Recruiting 1 30 Ayan Sen, MD 2020-12-15
Impact of sugars on patients diagnosed with COVID Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sri Ramachandra Institute of Higher Education and Research India 2021-01-01 CTRI/2020/12/029712 Phase Not Applicable Not yet recruiting 1 1000 Shravanthi Naidu S Woodayagiri, Swathy Moorthy 2020-12-15
Assessment of pulmonary function test in patients recovered from COVID19 infection Coronavirus disease 19 infection, Viral pneumonia spirometry alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) GMERS Medical College and Hospital India 2020-12-21 CTRI/2020/12/029669 Phase Not Applicable Not yet recruiting 1 50 Dr Anand Patel, Dr Richa Udhwani 2020-12-18
NO-Hel: Comparison of a helmet interface for non invasive ventilation versus high flow nasal oxygen therapy in management of corona virus patients Coronavirus disease 19 infection Hamilton C3 ventilator alone, non invasive ventilation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) All India Institute of Medical Sciences Patna India 2020-12-15 CTRI/2020/12/029711, NO-Hel Phase Not Applicable Not yet recruiting 1 56 NISHANT SAHAY 2020-12-14
HOM_COVID19: Add-on homeopathic treatment of COVID-19 patients Coronavirus disease 19 infection, Hypoxia, Respiratory distress syndrome, Viral pneumonia homeopathic medicine treatment alone, standard of COVID care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Council for Research in Homeopathy India 2021-01-01 CTRI/2020/12/029668, HOM_COVID19 Phase 2 Clinical Not yet recruiting 1 128 Dr Akash Khobragade, Dr Anil Khurana, Dr Naval Kumar Verma, Harleen Kaur 2020-12-18
Skin problems following the use of personal protective equipment Coronavirus disease 19 infection, Dermatological disease personal protective equipment usage alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kasturba Medical College India 2020-12-15 CTRI/2020/12/029663 Phase Not Applicable Not yet recruiting 1 100 Snigdha N Hegde 2020-12-19
The Status of Parathyroid Hormone Secretion in COVID-19 Patients Coronavirus disease 19 infection biochemical testing alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bezmialem Vakif University Turkey 2020-09-10 2020-12-09 08122020, NCT04662437 Phase Not Applicable Completed 1 3 Months 150 Derya Özalp Çelikçi, Dr, Sabahattin Destek 2020-12-17
AAIM-High: Assess and Adapt to the Impact of COVID-19 on CVD Self-Management and Prevention Care in Adults Living With HIV Coronavirus disease 19 infection, Hypertension EXTRA-CVD nurse-led virtual care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Case Western Reserve University Duke University, Metro Health, Michigan, National Heart Lung and Blood Institute, University Hospitals of Cleveland US 2021-02-28 2022-08-31 03-18-16-S1, AAIM-High, NCT04661813, U01HL142099 Phase Not Applicable Not yet recruiting 3 18 Months 75 Chris T Longenecker, MD, Robin Rentrope, MPH, LSW 2020-12-12
COPPS: COVID-19 Outpatient Pragmatic Platform Study: Master Protocol Coronavirus disease 19 infection acebilustat alone, camostat mesylate alone, standard supportive care alone Leukotriene A4 hydrolase inhibitor, Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stanford University US 2021-01-31 2022-01-31 COPPS, COPPS-MASTER PROTOCOL, NCT04662086 Phase 2 Clinical Not yet recruiting 1 12 Months 240 Chaitan Khosla, PhD, Haley Hedlin, PhD, Manisha Desai, PhD, Upinder Singh, MD, Yvonne Maldonado, MD 2020-12-18
EPAC: Efficacy of Homoeopathic prophylaxis Arsenicum Album against COVID-19 Coronavirus disease 19 infection, Viral pneumonia Arsenicum album alone Healthy volunteers accepted, Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) SRM University Ministry of Ayush India 2020-12-12 CTRI/2020/12/029745, EPAC Phase 2 Clinical Not yet recruiting 1 15000 Dr Alex Joseph, Prof Padma Venkat 2020-12-15
COPPS: COVID-19 Outpatient Pragmatic Platform Study: Camostat Sub-Protocol Coronavirus disease 19 infection camostat mesylate alone, standard supportive care alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stanford University US 2021-01-31 2022-01-31 COPPS, COPPS-CAMOSTAT, NCT04662073 Phase 2 Clinical Not yet recruiting 1 12 Months 120 Julie Parsonnet, MD 2020-12-18
Study of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults (USA) Coronavirus disease 19 infection AS-03 plus MT-2766 TLR-9 agonist Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medicago Inc 2020-12-11 2022-03-31 CP-PRO-COVLP-021(USA), NCT04662697 Phase 2 Clinical Not yet recruiting 0 15 Months 918 Brian Ward, MD 2020-12-15
COPPS: COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Acebilustat Sub-Protocol Coronavirus disease 19 infection acebilustat alone, standard supportive care alone Leukotriene A4 hydrolase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Stanford University US 2021-01-31 2022-01-31 COPPS, COPPS-ACEBILUSTAT, NCT04662060 Phase 2 Clinical Not yet recruiting 1 12 Months 120 Angela Rogers, MD, Joseph Levitt, MD, MS 2020-12-18
Blood changes in COVID-19 and it is influence Coronavirus disease 19 infection Beckman coulter DSX8 alone, COBAS 6500 alone, Sysmex CS 2400 alone Newborn Infants (up to 5 months) Sri Ramachandra Medical College, Hospital & Research institute India 2020-12-15 CTRI/2020/12/029671 Phase Not Applicable Not yet recruiting 1 800 Dr Febe Renjitha Suman, Dr JAYALAKSHMI B 2020-12-14
MICHELLE: Medically Ill Hospitalized Patients for COVID-19 Thrombosis Extended Prophylaxis With Rivaroxaban Therapy Coronavirus disease 19 infection, Thromboembolism, Viral pneumonia rivaroxaban alone Factor Xa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Science Valley Research Institute Bayer AG Brazil 2020-10-16 2021-06-30 21589 MICHELLE TRIAL, MICHELLE, NCT04662684 Phase 3 Clinical Recruiting 1 8 Months 320 Eduardo Ramacciotti,, Eduardo Ramacciotti, MD, Ph.D, Eduardo Ramacciotti, MD, PhD, Leandro Agati, PhD 2020-12-15
A retrospective, case series study presenting the significant challenges to kidney transplant recipients with risk for higher mortality due to COVID19 infection Coronavirus disease 19 infection, Kidney transplantation Variable regimens including anakinra , azithromycin , belatacept , cyclosporine , hydroxychloroquine , lisinopril , mycophenolate mofetil , prednisone , ravulizumab , tacrolimus ACE inhibitor, Calcineurin inhibitor, Complement C5 factor inhibitor, Cytotoxic T-lymphocyte protein-4 modulator, IgG receptor FcRn large subunit p51 modulator, Inosine monophosphate dehydrogenase inhibitor, PurH purine biosynthesis protein inhibitor, T cell surface glycoprotein CD28 inhibitor, Type I IL-1 receptor antagonist Allegheny Health Network Phase Not Applicable Status not specified 0 4 2020-12-11
Requirements analysis for a robotic assistive system to support and promote the autonomy of people with neuromuscular diseases Coronavirus disease 19 infection, Neuromuscular disease, Spinal muscular atrophy robotic assistance system alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Charite Universitaetsmedizin Berlin Deutsche Forschungsgemeinschaft (DFG), Evangelische Hochschule Ludwigsburg, German Federal Ministry of Education and Research Germany 2020-09-16 DRKS00022534, EA4/150/20, U1111-1257-2583 Phase Not Applicable Recruiting 2 15 Cornelia Eicher 2020-12-14
Analyzing impact of pre-existing comorbidities on serious adverse outcomes in hospitalised COVID19 patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Smart Super Speciality Hospital India 2020-12-21 CTRI/2020/12/029744 Phase Not Applicable Not yet recruiting 1 128 Nandani Gulati 2020-12-14
ReDiCare: Relieving Distressed Caregivers: A Pragmatic Trial Coronavirus disease 19 infection care counseling alone, stepped care model alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Friedrich Schiller University of Jena, Robert Bosch Hospital AOK Baden-Württemberg, Deutsche Forschungsgemeinschaft (DFG), German Federal Ministry of Education and Research Germany 2018-05-15 DRKS00014593, FSV 18/08, ReDiCare Phase 3 Clinical No longer recruiting 1 504 Gabriele Wilz, Klaus Pfeiffer 2020-12-14
Analyzing effect of COVID 19 on mental health of frontline healthcare workers Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Max Smart Super Speciality Hospital India 2020-12-21 CTRI/2020/12/029743 Phase Not Applicable Not yet recruiting 1 246 Nandani Gulati 2020-12-14
A clincial trial of PneumoBlast for the trreatment of covid-19 in Brazil Coronavirus disease 19 infection, Respiratory distress syndrome PneumoBlast alone FibroGenesis R4D Biotech Brazil Phase Not Applicable Planned 1 2020-12-14
A Study to Assess the Safety and Efficacy of CoroQuil-Zn 500 in Comparison to the Standard of Care for the Treatment of Mild to Moderate COVID-19 Coronavirus disease 19 infection CoroQuil-Zn alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Remedium Therapeutics Private Limited India 2020-12-15 CTRI/2020/12/029735 Phase 3 Clinical Not yet recruiting 0 100 Disha Shetty, Dr Sambashiva AC, Mr Mallikarjun Bidari 2020-12-14
ESTC: Phase II trial: evaluation of silymarin for treatment of patients with Covid-19 Coronavirus disease 19 infection Variable regimens including Silymarin , azithromycin , chloroquine/hydroxychloroquine , dexamethasone , vitamin- E , vitamin-C , zinc sulphate Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Jos University Teaching Hospital, University of Jos National Veterinary Research Institute Nigeria 2020-12-20 2021-08-27 ESTC, PACTR202012898601759 Phase 2 Clinical Not yet recruiting 2 8 Months 314 Emmanuel Nnadi, John Aguiyi, Nathan Shehu, Pam Luka, Shwe David, Simeon Omale 2020-12-18
A Clinical Safety Study on AT-100 in Treating Adults With Severe COVID-19 Infection Coronavirus disease 19 infection AT-100, Airway alone Lung surfactant associated protein D modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Airway Therapeutics LLC US 2021-01-31 2021-07-31 AT-100/002, NCT04659122 Phase 1b Clinical Not yet recruiting 1 6 Months 9 Marc O. Salzberg, MD, Neil P. Mills, BS, Paul S. Kingma, MD, PhD, Robert D. Hite, MD 2020-12-14
To Assess CT Chest finding of Post-covid Pneumonia Patient Coronavirus disease 19 infection, Pulmonary fibrosis, Viral pneumonia Chest CT scan alone, pirfenidone alone, prednisolone alone, pirfenidone plus prednisolone PDGF receptor antagonist, TGF beta receptor antagonist, p38 MAP kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) GMERS Medical College and Hospital India 2020-12-25 CTRI/2020/12/029733 Phase Not Applicable Not yet recruiting 0 50 Dr Anand Patel, Dr Nil Patel 2020-12-14
COLUMBIA CARDS: Covid-19 Longitudinal, Multi-ethnic, Bioimaging Assessment of Cardiovascular Sequela Registry Cardiovascular disease, Coronavirus disease 19 infection cardiovascular magnetic resonance imaging alone, gadoterate meglumine, GE healthcare alone, transthoracic echocardiogram analysis alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Columbia University GE Healthcare US 2020-12-31 2022-09-30 AAAT0787, COLUMBIA CARDS, NCT04661657 Phase Not Applicable Not yet recruiting 1 21 Months 18 Andrew J Einstein, MD, PhD, Frankie DeJesus, MS, Kathleen Durkin, MS 2020-12-19
SOUNDS: Surgery and Lung Ultrasound in SARS-CoV-2 Infection Coronavirus disease 19 infection lung ultrasound alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Fundacion Clinica Valle del Lili Colombia 2020-05-08 2021-11-30 1601, NCT04661631, SOUNDS Phase Not Applicable Recruiting 1 18 Months 451 Alberto F Garcia, MDMSc 2020-12-14
Aerobic Training Versus Cognitive Behavioral Therapy in Management of Anxiety Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression aerobic exercises alone, cognitive behavioral therapy alone Female, Young Adults (18-44 yrs) Cairo University Egypt 2020-12-10 2021-02-25 12-2020, NCT04662021 Phase Not Applicable Recruiting 0 2 Months 40 Marwa Eid 2020-12-15
CLOSER_MS: Offering Support and Electronic Resources for Care Partners of Those With Multiple Sclerosis Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression tele-coaching alone, website based information alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Case Western Reserve University US 2021-01-10 2021-10-31 CLOSER_MS, MS-1610-37015 enhancement, NCT04662008 Phase Not Applicable Not yet recruiting 1 9 Months 150 Amy R Lipson, PhD, Matthew Plow 2020-12-18
Health After Covid-19 in Tyrol Coronavirus disease 19 infection Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medizinische Universität Innsbruck Claudiana Landesfachhochschule Austria 2020-09-30 2021-12-31 20200928-2379, NCT04661462 Phase Not Applicable Recruiting 0 15 Months 1000 Judith Löffler-Ragg, MD 2020-12-16
A Study of Auxora in Patients With Critical COVID-19 Pneumonia Coronavirus disease 19 infection, Viral pneumonia CM-4620 alone Ca2+ release activated Ca2+ channel 1 inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CalciMedica Inc Northwestern University US 2020-12-31 2021-04-30 CM4620-205, NCT04661540 Phase 2 Clinical Not yet recruiting 1 4 Months 36 Richard Wunderink, MD, Richard Wunderlink, MD, Sudarshan Hebbar 2020-12-14
MONIREA: Use of RDS MultiSense in Post-ICU Patients in the COVID-19 Era Coronavirus disease 19 infection, Viral pneumonia MultiSense strip alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hopitaux Universitaires de Strasbourg Rhythm Diagnostics Systems Inc France 2021-06-30 2022-06-30 20-004, MONIREA, NCT04661423 Phase Not Applicable Not yet recruiting 0 12 Months 60 Armelle TAKEDA, PhD, Julien POTTECHER, MD, PhD 2020-12-14
Reward Re-Training: A New Treatment to Address Reward Imbalance During the COVID-19 Pandemic Coronavirus disease 19 infection, Eating disorder reward re-training group therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Drexel University The National Institute of Mental Health US 2020-12-01 2022-03-30 2009008088, NCT04661410, R01MH122392-01S1 Phase Not Applicable Recruiting 1 15 Months 60 Research Coordinator 2020-12-14
MejoraCare_P: MejoraCare-Paraguay: mHealth Solution for Chronic Patients During the COVID-19 Outbreak in Paraguay Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection MejoraCare app alone, Routine care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidad Autónoma de Encarnación Salumedia Labs, University of Valencia Paraguay 2020-12-09 2021-12-09 MejoraCare_P, NCT04659746, PINV 20-9 Phase Not Applicable Not yet recruiting 1 12 Months 96 Carmen Cabral, Matías Denis, Nadia Czeraniuk, Rosa María Baños, PhD 2020-12-15
FENOC: Fenofibrate for Patients With COVID-19 Requiring Hospitalization Coronavirus disease 19 infection fenofibrate (micronized), Fournier/Abbott alone, usual medical care alone Lipoprotein lipase stimulator, PPAR alpha agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hebrew University of Jerusalem Barzilai medical center Israel 2020-12-13 2021-12-01 0105-20-BRZ, FENOC, NCT04661930 Phase 3 Clinical Recruiting 0 11 Months 50 Avner Ehrlich, Mahram Nassar, MD, Shlomo Mayaan, MD, Yaakov Nahmias, PhD 2020-12-14
COVEPICARDIO: The Cognitive and sport Virtual EPIC Training Study for Cardiovascular Diseases Atherosclerosis, Atrial fibrillation, Coronavirus disease 19 infection, Diastolic heart failure, Systolic heart failure home-based cognitive training alone, physical exercise training alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Montreal Heart Institute Canada 2020-05-18 2022-12-01 COVEPICARDIO, ICM 2020-2785, NCT04661189 Phase Not Applicable Recruiting 0 30 Months 118 Florent Besnier, PhD, Louis Bherer, PhD 2020-12-15
A Study to Assess the Effectiveness of ImmuRich in COVID-19 Positive Patients Coronavirus disease 19 infection ImmuRich capsule (RPS Biotech Private Limited) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) RPS BIOTECH PVT LTD India 2020-12-15 CTRI/2020/12/029713 Phase 2 Clinical Not yet recruiting 0 100 DR MANOJ RUNGHE 2020-12-14
Koa Family Study: A Community-Based Intervention to Improve Health and Well-Being (KFS) Coronavirus disease 19 infection, Obesity Whole health program alone, health messages texting alone, mind-body-spirit intervention alone, social media support alone, tree planting alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University of California Davis US 2021-01-31 2021-09-30 1668154, Koa Family Study, NCT04662593 Phase Not Applicable Not yet recruiting 1 8 Months 120 Crystie Dao, MS, Desiree Backman, DrPH, MS, RD, Neal Kohatsu, MD, MPH 2020-12-14
CAPNOR: Impact of Molecular Testing on Improved Diagnosis, Treatment and Management of CAP Coronavirus disease 19 infection, Pneumonia BioFire FilmArray Pneumonia plus platform (Biomerieux) alone, active feedback alone, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry alone, microbiological biochemical testing alone, real-time PCR alone, ultra-rapid molecular testing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Haukeland University Hospital Copenhagen University, Drammen Hospital, Quadram Institute Bioscience, Rigshospitalet, Universitair Medisch Centrum Utrecht, University Of Southampton, University of Bergen Norway 2020-09-25 2022-12-31 CAPNOR, HAUKELANDUH_31935, NCT04660084 Phase Not Applicable Recruiting 1 27 Months 1060 Elling Ulvestad, MD PhD, Harleen Grewal, MD PhD, Rune Bjørneklett, MD PhD 2020-12-14
ASCO: ASCO Survey on COVID-19 in Oncology Registry Cancer, Coronavirus disease 19 infection American Society of Clinical Oncology US 2020-04-19 2022-12-31 ASCO, NCT04659135, PRO00014181 Phase Not Applicable Recruiting 63 32 Months 2000 Adam Al Douri, Alexander Spira, Amol Rao, Angie Dunbar, Anthony Franklin, Ashley Jones, Brandon Bennett, Brenda Groff, Charu Aggarwal, Christopher Laman, Christopher McNair, Christy Hughes, Danielle Geiger, Dara Richie, Debbie Vidlak, Elizabeth Garrett-Mayer, PhD, Eric Clayton, Eric Small, Gina Cravey, Hailey Johnson, Ihab Azab, Jamie Harper, Jen H Williams, MA, Jennifer Orlando, Karen Sceniak, Kathryn Mileham, Kelly Hattery, Kent Disney, Kevin Mills, Kimberly Maher, Latha Subramanian, Lisa Kosmacek, Lori Backus, Lynn Harrison, Mandy Joosten, Margaret Mazzone, Mary Amos, Matthew Carter, Matthew Korzeniewski, Melanie Meehan, Michelle Britto, Milan Sheth, Nancy Studier, Nicole Fowler, Peter Yu, Philip Lammers, Poornima Saha, R. Donald Harvey, PharmD, Richard L Schilsky, MD, Rosie Drulias, Rudi Ross, Sandra Guy, Scott Baker, Stephanie McClellan, Suanna S Bruinooge, MPH, Susan Knight, Susan Moore, Tara Barker, Thomas Semrad, Thorvardur Halfdanarson, Tina Inverso, Uzma Rizwan, Wasif Saif, Williams Wood 2020-12-14
Phase I Study to Evaluate Safety and Pharmacokinetics of COVID-HIGIV Administered as a Single Dose or a Repeat Dose in Healthy Adults Coronavirus disease 19 infection COVID-HIG alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Emergent BioSolutions Inc US Department of Defense US 2020-12-31 2021-09-30 EBS-CVH-003, NCT04661839 Phase 1 Clinical Recruiting 1 9 Months 56 Clinical Trial Manager 2020-12-18
Adolescents With COVID-19/MIS-C at HCFMUSP Coronavirus disease 19 infection home-based exercise training program alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs) University of Sao Paulo Fundacao de Amparo a Pesquisa do Estado Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Brazil 2020-09-24 2021-04-30 37460620.8.0000.0068, NCT04659486 Phase Not Applicable Recruiting 0 7 Months 100 Bruno Gualano, Clovis Silva, PhD 2020-12-14
Phase I/II Randomized, Dose Escalation Study to Evaluate the Safety and Antiviral Activity of the RD-X19 Device in SARS-CoV-2 Infected Individuals With Uncomplicated COVID-19 Coronavirus disease 19 infection RD-X19 alone, electromagnetic treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) EmitBio Inc. KNOW Bio LLC US 2020-11-18 2021-04-30 EB-P12-01, NCT04662671 Phase 1/Phase 2 Clinical Recruiting 2 5 Months 60 EB-P12-01 Study Director 2020-12-14
ACP-COVID: Advance Care Planning: Communicating With Outpatients for Vital Informed Decision Coronavirus disease 19 infection ACP Decisions Video Program alone, VitalTalk communication skills training alone, intervention training alone, medical record review alone Healthy volunteers accepted, Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dana-Farber Cancer Institute Inc National Institute on Aging US 2020-12-15 2021-05-14 20-600, ACP-COVID, NCT04660422, UH3AG060626-03S1 Phase Not Applicable Recruiting 1 5 Months 13150 Edith Burns, MD, James A. Tulsky, MD 2020-12-17
NOSOCOVID: Nosocomial COVID-19 in ICU Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) CHU De Nantes France 2020-09-01 2021-03-01 MR_NOSOCOVID, NCT04659356, NOSOCOVID Phase Not Applicable Recruiting 0 6 Months 600 BOURIGAULT Celine, MD, CANET Emmanuel, PHd, GARRET Charlotte, GARRET Charlotte, MD, LASCARROU Jean-Baptiste, MD, LEMARIE Jeremy, MD, MARTIN Maelle, MD, REIGNIER Jean, PHd 2020-12-14
Tele-RehaB: Pulmonary Tele-Rehabilitation Program: Feasibility and Safety Study Coronavirus disease 19 infection, Respiratory disease pulmonary telerehabilitation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec Fondation IUCPQ Canada 2020-12-31 2022-01-31 21983, NCT04658979, Tele-RehaB Phase Not Applicable Recruiting 0 13 Months 30 Didier Saey, Ph.D, Didier Saey, PhD, Jany Harvey, M.Sc. 2020-12-14
Factors Affecting Mortality in Critical Patients Admitted to Intensive Care Unit Due to COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital Turkey 2020-03-22 2020-12-08 NCT04659876, SEPTEMBER 11, 2020: 550 Phase Not Applicable Completed 0 8 Months 445 Osman Uzundere 2020-12-15
Combination therapy trial in COVID-19 patients Coronavirus disease 19 infection antibiotic treatment alone, anticoagulant treatment alone, antiviral treatment alone, sitagliptin alone, spironolactone alone, supplement intake alone, Variable regimens including dexamethasone , sitagliptin , spironolactone Aldosterone antagonist, Dipeptidyl peptidase IV inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Boushehr University of Medical Sciences Iran 2020-12-05 IR.BPUMS.REC.1399.140, IRCT20201003048904N2 Phase 2 Clinical Recruiting 0 200 Farhad Abbasi, Farzan Azodi, Gholamreza Khamisipour 2020-12-14
Cancer Within a Pandemic: A Telemental Health Intervention Anxiety disorder, Cancer, Coronavirus disease 19 infection, Depression online support group test alone, questionnaires alone, telemental health session alone Young Adults (18-44 yrs) Wake Forest University Health Sciences, US National Cancer Institute US 2021-02-28 2021-07-31 IRB00070150, NCT04659993, P30CA012197, WFBCCC01520 Phase Not Applicable Not yet recruiting 1 5 Months 15 Katie Duckworth, Ph.D, Katie Duckworth, PhD, Study Coordinator 2020-12-15
The mechanism of COVID-19 associated coagulopathy: a prospective, cohort study Blood clotting disorder, Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tohoku University Japan Agency for Medical Research and Development Japan 2020-11-09 UMIN000042717 Phase Not Applicable Recruiting 0 100 Koji Saito, Yudai Iwasaki 2020-12-14
COVID-19 (coronavirus Disease 2019) Coronavirus disease 19 infection, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HOSPITAL LAHAD DATU Malaysia 2020-12-14 2021-01-14 57156, NMRR-20-2655-57156 Phase Not Applicable Status not specified 1 1 Month 300 Dr WONG YEN SHEN 2020-12-17
COVID-19 Infection among Healthcare Workers Coronavirus disease 19 infection Ministry of Health, Malaysia Malaysia 2020-12-14 2021-03-13 57584, NMRR-20-2648-57584 Phase Not Applicable Status not specified 0 3 Months Dr Abdul Aziz Harith 2020-12-14
COVID-19 pandemic and breast cancer management: An observational clinical study from Pakistan Breast tumor, Coronavirus disease 19 infection breast cancer surgery alone, neoadjuvant/systemic chemotherapy alone, telecommunication alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Aga khan University Aga Khan University Hospital karachi Pakistan 2020-03-14 2020-10-03 2020-5418-14043, DRKS00023807 Phase Not Applicable Completed 0 6 Months 112 Dua Jabeen, Narmeen Asif 2020-12-14
TRISSR: Impact of The New Triage System and Structural Reorganization of Emergency Department on Health Care Worker Exposed to Suspected Covid-19 Patients - A Single Center Analysis Coronavirus disease 19 infection Healthy volunteers accepted Hospital Kuala Lumpur Malaysia 2020-12-05 2021-01-27 57197, NMRR-20-2636-57197, TRISSR Phase Not Applicable No longer recruiting 1 1 Month Dr Mahathar Abdul Wahab, SUFIAN BIN SAFAAI 2020-12-15
Spanish Survey on Third Wave of COVID-19 Coronavirus disease 19 infection Healthy volunteers accepted Universidad De Salamanca Spain 2020-12-09 2020-12-20 COVIDSAL01/2020, NCT04659473 Phase Not Applicable Not yet recruiting 0 1000 Beatriz M Bermejo-Gil, Professor, Fátima Pérez-Robledo, Doctor, Fátima Pérez-Robledo, Professor, Inés Llamas-Ramos, Doctor, Inés Llamas-Ramos, Professor, Juan L Sánchez-González, Professor, Rocío Llamas-Ramos, Professor 2020-12-15
A randomized, double-blind, placebo-controlled Phase II Clinical Trial to evaluate the safety and efficacy of a combination treatment of two drugs, and the best supportive care for patients with moderate and severe COVID-19 in a hospitalized setting Coronavirus disease 19 infection combination of two drugs alone Venn Life Sciences Phase 2 Clinical Status not specified 0 200 2020-12-11
ProBCG: Use of BCG Vaccine as a Preventive Measure for COVID-19 in Health Care Workers Coronavirus disease 19 infection BCG vaccine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidade Federal do Rio de Janeiro Ministry of Science and Technology, Brazil Brazil 2020-10-01 2022-10-01 31942220.8.1001.5257, NCT04659941, ProBCG Phase 2 Clinical Recruiting 1 24 Months 1000 Fernanda CQ Mello, PhD, Fernanda Carvalho de Q Mello, PhD, JOSE ROBERTO LAPA E SILVA 2020-12-17
Evaluation of Aerosol in a Dental Clinic Coronavirus disease 19 infection external evacuation device alone, extraoral vacuum aspirator alone, high volume evacuation suction device alone, hydrogen peroxide alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Texas Health Science Center Houston US 2020-12-01 2022-12-01 HSC-DB-20-1017, NCT04659928 Phase 4 Clinical Not yet recruiting 1 24 Months 50 Aaron Glick, DDS, FAGD, FICOI, D.ABDSM 2020-12-14
CORONADO: Circulating Tumor Protein Quantification Capillary Blood COVID Coronavirus disease 19 infection, Multiple myeloma, Plasma cell dyscrasia at-home blood sampling alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institute of Cancer Research UK The Royal Marsden NHS Trust UK 2021-01-15 2021-10-01 CCR5361, CORONADO, NCT04659252 Phase Not Applicable Not yet recruiting 0 8 Months 70 Chloe Burrows, Haemato-oncology Research Team, Kevin Boyd 2020-12-14
Stress situation survey for hospital staff related to the new coronavirus Acute stress disorder, Coronavirus disease 19 infection Audio slides alone, brief pamphlet alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nagasaki University Japan 2020-12-14 UMIN000042689 Phase Not Applicable Not yet recruiting 1 800 Hirohisa Kinoshita 2020-12-17
A trial to evaluate Covid-19 vaccine for the prevention of Covid-19 Coronavirus disease 19 infection Covid-19 vaccine, VLP Therapeutics LLC alone VLP Therapeutics LLC National Center For Global Health & Medicine, National Institute of Biomedical Innovation, Oita University, Osaka City University Japan Phase Not Applicable Planned 0 2020-12-10
RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective, Randomized, Pilot Study Coronavirus disease 19 infection, Ischemia, Viral pneumonia remote ischemic conditioning alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Michaels Hospital Canadian Department of National Defence Canada 2020-12-15 2021-09-01 1.4, NCT04659460 Phase Not Applicable Not yet recruiting 0 8 Months 30 Sandy Trpcic 2020-12-15
Thyroid Function Tests and Status of Thyroid Autoantibodies in Covid-19 Patients Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bezmialem Vakif University Turkey 2020-09-01 2020-12-07 06122020, NCT04659200 Phase Not Applicable Recruiting 0 3 Months 20 Aysegul Yabacı, Research, Didem Ertorul, Dr, Sabahattin Destek, Sabahattin Destek, Associate Professor 2020-12-15
Hyperpolarized 129-Xe MRI of Survivors of COVID-19 Coronavirus disease 19 infection 129-Xe MRI alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Kansas Medical Center US 2021-01-01 2021-12-31 00146646, NCT04659707 Phase 1 Clinical Not yet recruiting 1 12 Months 20 Peter J Niedbalski, PhD, Peter J. Niedbalski 2020-12-14
A first global investigator-initiated phase-2 clinical trial in Mexico for camostat mesilate being developed as COVID-19 treatment Coronavirus disease 19 infection repurposed camostat mesilate (oral, COVID-19), Daewoong/Institut Pasteur Korea/Korea Institute of Radiological and Medical Sciences alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Daewoong Pharmaceutical Co Ltd, Institut Pasteur Korea, Instituto Nacional de Ciencias Medicas y Nutricion, Korea Institute of Radiological and Medical Sciences Mexico 2020-12-09 Phase 2 Clinical Status not specified 0 2020-12-10
Study Evaluating Safety, Tolerability and Efficacy of Allocetra-OTS in Patients With COVID-19 Coronavirus disease 19 infection Allocetra alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Enlivex Therapeutics Ltd 2021-03-31 2022-03-31 ENX-CL-03-001, NCT04659304 Phase 1b Clinical Not yet recruiting 0 12 Months 50 Lior Binder, Odelia Ben Shitrit, MBA, Oren Hershkovitz, PhD 2020-12-11
A trial to evaluate Soberana 01 for the prevention of COVID-19 Coronavirus disease 19 infection FINLAY-FR-1 alone Finlay Institute Cuba Phase Not Applicable Not yet recruiting 1 2020-12-17
An observational study to evaluate the impact of COVID-19 on children with cystic fibrosis Coronavirus disease 19 infection, Cystic fibrosis Cystic Fibrosis Foundation Phase Not Applicable Status not specified 0 105 2020-12-10
Remdesivir plus Tocilizumab efficacy trial in moderate to severe COVID-19 patients Coronavirus disease 19 infection remdesivir plus tocilizumab COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medical College Kolkata India 2020-12-15 CTRI/2020/12/029615 Phase 2 Clinical Not yet recruiting 1 60 Dr Swati Datta 2020-12-16
Clinical Assessment of Insulin Fast Dissolving Film in Treatment of Post Infection Anosmia Coronavirus disease 19 infection, Dysomia insulin alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Deraya University Minia University Egypt 2020-12-01 2021-01-15 NCT04657809, S85INSU23FDF Phase 2 Clinical No longer recruiting 0 1 Month 40 Soad Ali, Soad Mohamed 2020-12-11
ASPEN-COVID-19: Assessing Safety, Hospitalization and Efficacy of rNAPc2 in COVID-19 Blood clotting disorder, Coronavirus disease 19 infection AB-201, Arca Biopharma alone Factor VII antagonist, Tissue factor inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) ARCA Biopharma Inc Colorado Prevention Center, University of Colorado US 2020-12-10 2021-05-31 ASPEN-COVID-19, NAPc-201/301, NCT04655586 Phase 2/Phase 3 Clinical Recruiting 3 5 Months 100 Dr Michael Bristow, Jennifer Meriwether, Marc Bonaca, MD, MPH 2020-12-19
The Effect of Omega-3 Supplements on the Serum Levels of ACE/ACE2 Ratio as a Potential Key in Cardiovascular Disease and COVID-19: A Randomized Clinical Trial in the COVID-19 Uninfected Jordanian People Cardiovascular disease, Coronavirus disease 19 infection omega-3 fatty acids alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Applied Science Private University Jordan 2020-12-05 2021-03-30 2020-PHA-22, NCT04658433 Phase Not Applicable Recruiting 0 3 Months 100 Luai z Hasoun, PhD, Mahmoud S Abu-Samak, PhD, Mahmoud Suleiman Abu-Samak, Sara M Daboul, MSC, Sara M Daboul, Master, luai z Hasoun, PhD 2020-12-11
OXYCOVID: Liberal use of oxygen in early stage of COVID-19 patients Coronavirus disease 19 infection oxygen alone, usual care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AIIMS Jodhpur India 2020-12-16 CTRI/2020/12/029614, OXYCOVID Phase 2 Clinical Not yet recruiting 0 80 Dr Mahendra Kumar Garg 2020-12-14
GARDEN: Glenzocimab in SARS-Cov-2 Acute Respiratory Distress Syndrome Related to COVID-19 Coronavirus disease 19 infection, Dyspnea, Respiratory distress syndrome glenzocimab alone Platelet glycoprotein VI inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Acticor Biotech 2020-12-31 2021-07-31 2020-002733-15, ACT-CS-006, GARDEN, NCT04659109 Phase 2 Clinical Not yet recruiting 0 7 Months 60 Andrea Comenducci, MD, Yannick Pletan, MD 2020-12-11
Drug to prevent lung injury secondary to COVID 19 Acute lung injury, Coronavirus disease 19 infection Heparin alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute Of Medical Sciences, Rishikesh India 2020-12-14 CTRI/2020/12/029613 Phase 2 Clinical Not yet recruiting 1 30 Bhavna Gupta 2020-12-16
CORONA Germany: Clinical Outcome and Risk in Hospitalized COVID-19 Patients: A Registry From Germany Arterial thrombosis, Cancer, Cardiac arrest, Cardiac failure, Cardiogenic shock, Coronary artery disease, Coronavirus disease 19 infection, Heart arrhythmia, Ischemic stroke, Lung embolism, Myocardial infarction, Myocarditis, Phlebothrombosis Asklepios Proresearch Asklepios Kliniken Hamburg GmbH Germany 2020-03-26 2021-07-01 #3871, CORONA Germany, NCT04659187 Phase Not Applicable Recruiting 0 15 Months 4000 Axel Stang, Prof. MD, Bertholt Bein, Prof. MD, Christian Glöckner, MD, Christoph U Herborn, Prof. MD, Dirk Arnold, Prof. MD, Hans-Peter Hauber, MD, Jürgen Behr, Prof. MD, Klaus Herrlinger, Prof. MD, Lorenz Nowak, MD, Martin Bergmann, Prof. MD, Melanie Gunawardene, MD, Nele Gessler, MD, Rüdiger Schreiber, MD, Sebastian Wirtz, MD, Stephan Willems, Prof. MD, Thomas Hölting, MD, Tino Schnitgerhans, MD, Ulrich-Frank Pape, MD 2020-12-14
A study on efficacy of combined Chinese and Western medicine and follow-up of long-term prognosis in patients with novel coronavirus pneumonia (COVID-19) Carbohydrate metabolism disorder, Cardiovascular disease, Cerebrovascular disease, Coronavirus disease 19 infection, Renal disease, Respiratory disease, Viral pneumonia different treatment regimens (combined Chinese and Western medicine) alone Public Health Clinical Center of Chengdu China 2021-01-10 2021-05-30 ChiCTR2000040770, ChiMCTR2000004148 Phase Not Applicable Recruiting 0 4 Months 300 Chen Qing, Wu Guihui 2020-12-11
Clinical and Hematological Phenotypes in Long COVID Coronavirus disease 19 infection, Inflammatory disease peripheral blood immunophenotyping alone, serum biochemistry analysis alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HCA International UK 2020-12-31 2021-06-30 LCV, NCT04659889 Phase Not Applicable Recruiting 0 6 Months 100 Dr Paul Glynne, Mr Glynne, Dr, Natasha Tahmasebi, Miss, Paul Glynne, Dr, Rajeev Gupta, Dr, Vanya Gant, Dr 2020-12-14
A Phase 1/2 randomized, placebo-controlled, multi-centre study to evaluate the safety and immunogenicity of a novel Receptor Binding Domain (RBD) COVID-19 Vaccine in Healthy Adults Coronavirus disease 19 infection RBD SARS-CoV-2 HBsAg VLP (CpG 1018 (150 mcg) or Alum ) alone, RBD dose plus Alum alone, RBD dose with Alum adjuvant plus CpG 1018 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) ACCELAGEN PTY LTD, Serum Institute of India Privated Ltd Australia 2020-12-09 ACTRN12620001308987 Phase 1/Phase 2 Clinical Not yet recruiting 2 255 Mr Greg Plunkett, Prof Terry Nolan 2020-12-16
Optimized TCM diagnosis and treatment plan for novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection, Viral pneumonia Traditional Chinese Medicine alone, conventional treatment alone, integrated Chinese and conventional medicine alone Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University Beijing science and Technology Commission China 2020-12-01 2021-01-31 ChiCTR2000040765, ChiMCTR2000004147 Phase Not Applicable Recruiting 0 2 Months 700 Liu Qingquan, Su Rui 2020-12-11
A survey of the impact on mental health and therapies in patients with chronic disease during the pandemic of COVID-19 Anxiety disorder, Coronavirus disease 19 infection, Depression Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The First Affiliated Hospital of college of medicine Zhejiang University China 2020-10-10 ChiCTR2000040729 Phase Not Applicable Recruiting 0 800 Minglan Wu 2020-12-11
FACE COVID-19: Femoral Fractures and COVID-19 Coronavirus disease 19 infection, Lower limb fracture Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto Ortopedico Galeazzi Spa Italy 2020-11-14 2020-12-31 FACE COVID-19, FACE COVID-19, NCT04657510 Phase Not Applicable Recruiting 0 1 Month 140 Francesca Villa, MSc, Francesco Luceri, MD, Giuseppe M Peretti, MD, Ilaria Morelli, MD, Riccardo Giorgino, MD 2020-12-11
TBA: Pulmonary and fitness characteristics of COVID-19 patients with persistent dyspnea and / or reduced exercise capacity Coronavirus disease 19 infection, Dyspnea pulmonary function tests alone Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Onze Lieve Vrouwe Gasthuis Amsterdam Netherlands 2020-06-01 2021-12-31 NL9093, TBA, WO 20.148 Phase Not Applicable Recruiting 1 19 Months 100 Tom Wiggers 2020-12-17
COVID-PRICE: COVID-19 Pregnancy Related Immunological, Clinical and Epidemiological Factors and Perinatal Outcomes Coronavirus disease 19 infection Female Thomas Jefferson University The Nemours Foundation US 2020-11-17 2022-06-30 20F.1043, COVID-PRICE, NCT04659759 Phase Not Applicable Recruiting 1 19 Months 50 Rupsa C Boelig, MD 2020-12-11
Effectiveness of internet psychotherapy in reduction of anxiety/depression of infertile women Anxiety disorder, Coronavirus disease 19 infection, Depression online cognitive behavioral therapy alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) National Institute for Medical Research Development Iran 2020-12-05 IR.NIMAD.REC.1398.174, IRCT20110228005931N9 Phase Not Applicable Recruiting 0 60 Dr. Farzan Kheirkhah, Dr. Farzan Kheyrkhah, Dr. Zahra Basirat, mahboobe faramarzi, shiva shafie rizi 2020-12-11
Expanded Access to Zofin (Organicell Flow) for Patients With COVID-19 Coronavirus disease 19 infection Zofin (Organicell Flow) alone, standard of care alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Organicell Regenerative Medicine bioRASI LLC 19881-EA, NCT04657406 Phase Not Applicable Recruiting 0 Mari Mitrani, MD, PhD 2020-12-14
Expanded Access Protocol on Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicle Infusion Treatment for Patients With COVID-19 Associated ARDS Adult respiratory distress syndrome, Coronavirus disease 19 infection, Hypoxia, Respiratory failure ExoFlo alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Direct Biologics LLC DB-EAP-001, NCT04657458 Phase Not Applicable Recruiting 0 Heidi Moran 2020-12-11
A Study of FOY-305 in Patients With SARS-Cov-2 Infection (COVID-19) Coronavirus disease 19 infection camostat mesylate alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ono Pharmaceutical Co Ltd Japan 2020-11-09 2021-05-31 FOY305-01, NCT04657497 Phase 3 Clinical Recruiting 0 6 Months 110 Naoyuki Komura 2020-12-11
COFATSOM: Fatigue and Sleep in Patients With COVID-19 Coronavirus disease 19 infection, Fatigue Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University Hospital, Bordeaux 2020-12-05 2021-06-30 CHUBX 2020/52, COFATSOM, NCT04657419 Phase Not Applicable Not yet recruiting 0 6 Months 720 Pierre PHILIP, Pr 2020-12-15
COVIDTEL: Parental Compliance After Telephone Triage Advice During and After Confinement During the COVID Epidemic in France Coronavirus disease 19 infection formalized telephone triage advice alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Fondation Lenval France 2020-12-31 2021-03-31 20-HPNCL-03, COVIDTEL, NCT04656444 Phase Not Applicable Not yet recruiting 0 3 Months 250 Antoine TRAN, Antoine TRAN, MD 2020-12-11
The Impact of COVID-19 on Surgical Practice in Jordan During the Second Outbreak: A Survey Coronavirus disease 19 infection Healthy volunteers accepted Yarmouk University Jordan 2020-11-01 2020-11-10 ChiCTR2000040633 Phase Not Applicable No longer recruiting 0 60 Raed M Ennab 2020-12-11
UNITED: At-Home Infusion Using Bamlanivimab in Participants With Mild to Moderate COVID-19 Coronavirus disease 19 infection bamlanivimab alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Aged Adults (65-79 yrs), Elderly Adults (80 and over) UnitedHealth Group Inc Eli Lilly & Co, Optum Inc US 2020-12-31 2021-05-31 2020-0081_, NCT04639479, NCT04656691, UNITED Phase 4 Clinical Not yet recruiting 1 5 Months 7500 Dan Griffin, MD, PHD, Michelle Tanner, BA, Tracy Ziolek, MS 2020-12-11
Effect Of Covid-19 Disease In Smell And Taste Of Patients With Mild, Moderate Or Severe Symptomatology Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Ioannina General Hospital of Ioannina G. Hatzikosta Greece 2020-11-17 2021-06-30 931/17-11-2020, NCT04657445 Phase Not Applicable Recruiting 0 7 Months 100 AIKATERINI LIANOU, SPECIALIST, ANGELOS LIONTOS, CONSULTANT, ATHINA ZARACHI, SPECIALIST, CHARALAMPOS MILIONIS, PROFESSOR, ELEFTHERIOS KLOURAS, RESIDENT, IOANNIS KASTANIOUDAKIS, PROFESSOR, IOANNIS KOMNOS, CONSULTANT, Liontos Angelos, MARIA MICHALI, SPECIALIST, angelos liontos, consultant 2020-12-11
COVIDVacImpac: Impact of the COVID-19 Pandemic on Vaccination Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-11-01 2021-05-30 COVIDVacImpac, NCT04657263, RECHMPL20_0655 Phase Not Applicable Recruiting 2 6 Months 500 Ariane Sultan, Ariane Sultan, MD, Cyril BREUKER, Cyril BREUKER, PharmD,Phd, cyril BREUKER 2020-12-14
A phase III trial to evaluate CoviSafe for the detection of COVID-19 Coronavirus disease 19 infection CoviSafe alone Kannaba Technologies Inc Therma Bright Inc Phase 3 Clinical Planned 0 2020-12-10
A phase II trial to evaluate CoviSafe for the detection of COVID-19 Coronavirus disease 19 infection CoviSafe alone Kannaba Technologies Inc Therma Bright Inc Phase 2 Clinical Planned 0 2020-12-11
A phase I trial to evaluate CoviSafe for the detection of COVID-19 Coronavirus disease 19 infection CoviSafe alone Kannaba Technologies Inc, Therma Bright Inc Phase 1 Clinical Planned 0 2020-12-11
Brief Mindfulness-Based Intervention to Improve Psychological Wellbeing Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Psychiatric disorder virtual brief mindfulness session alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Imam Abdulrahman Bin Faisal University Saudi Arabia 2020-07-07 2020-09-05 MINDFULLNESS during COVID19, Mindfullness during a pandemic, NCT04656626 Phase Not Applicable Completed 0 1 Month 146 Amani al-qurni, BOARD 2020-12-14
Disinfection & cross infection tests on sports equipment in covid-19 Coronavirus disease 19 infection a cross-infection test alone, disinfectants alone, test gloves alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St Marianna University School of Medicine Japan 2020-10-28 UMIN000042270 Phase Not Applicable Not yet recruiting 0 41 Hiroto Fujiya, Kanaka Yatabe 2020-12-10
NgT-NAFOGA(NATION) Study: Phase I clinical trial to investigate the safety, tolerability and pharmacokinetics of NewGenNafamostat in healthy male subjects Coronavirus disease 19 infection nafamostat (COVID-19 infection), Institut Pasteur Korea alone Serine protease inhibitor, Transmembrane serine protease 2 inhibitor Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) NewGen Therapeutics Inc NewGen Therapeutics Inc South Korea 2020-12-05 KCT0005647, NgT-NAFOGA(NATION), NgT-NAFOGA(NATION) Study Phase 1 Clinical Not yet recruiting 0 32 Hyun Chul Kim, Seung Hwan Lee 2020-12-10
MORPH-II: Revisiting A Mobile Intervention to Reduce Pain and Improve Health Coronavirus disease 19 infection, Pain caloric restriction intervention alone, movement restriction intervention alone Healthy volunteers accepted, Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Wake Forest University US 2021-01-31 2022-10-31 IRB00023965, MORPH-II, NCT04655001 Phase Not Applicable Not yet recruiting 1 21 Months 100 Amber Brooks, MD, Charlotte Crotts, BS, Jason Fanning, PhD 2020-12-10
DIRECTOR: Dynamics of the Immune Response to COVID-19/Infection by SARS-CoV-2 Coronavirus disease 19 infection, Respiratory tract infection Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universitat des Saarlandes MeMed Diagnostics Ltd Germany 2020-12-02 2021-11-30 109/20, DIRECTOR, NCT04655521 Phase Not Applicable Recruiting 0 11 Months 300 Cihan Papan, MD 2020-12-19
Urine Alkalinization to Prevent AKI in COVID-19 Coronavirus disease 19 infection, Renal injury sodium bicarbonate alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Guy's & St Thomas' Hospital NHS Trust UK 2021-02-01 2022-03-30 283852, NCT04655716 Phase 3 Clinical Not yet recruiting 0 13 Months 80 Marlies Ostermann 2020-12-11
Hospitalization or Outpatient Management of Patients With SRAS-CoV-2 Infection - Revised HOME-CoV Score Study Coronavirus disease 19 infection revised HOME-CoV score alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Angers France 2020-12-08 2021-06-08 2020-A03067-32, NCT04657471 Phase Not Applicable Not yet recruiting 0 6 Months 1300 Alexandre GHUYSEN, Andrea PENALOZA, Anyhony CHAUVIN, Caroline SOULIE, Christian BRICE, Coralie CAYEUX, David DALL'ACQUA, Delphine DOUILLET, Emmanuel MONTASSIER, Esma OUMMAMAR, Florent FREMY, Francis COUTURAUD, Frédéric BALEN, Henri Hani KARAM, Henrinjatovo ANDRIANJAFY, Julie PERNET, Kasarra BEN HAMMOUDA, Laure ABENSUR VUILLAUME, Marc ANDRONIKOF, Marc NOIZET, Mathieu VIOLEAU, Medhi TAALBA, Meïssa KARE, Mustapha SEBBANE, Nicolas PESCHANSKI, Ombeline SUSONG, Pascal BISSOLOKELE, Pierre-Clément THIEBAUD, Romain BLONDET, SCHMIDT Jeannot, Sonja CURAC, Stéphane GENNAI, Séverine GOSSELIN, Yann-Erick CLAESSENS 2020-12-15
Multiple Interactive With Nutrition and Exercise Strategies in Frailty Cancer Patients Coronavirus disease 19 infection, Muscle weakness cycle exercise alone, online nutrition consultation alone, routine nutrition consultation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tzu Chi University Taiwan 2020-11-01 2023-11-30 NCT04654637, TCU-CHHUANG Phase Not Applicable Recruiting 0 37 Months 128 Chu Hou Huang, PhD, Chun Hou Huang, Chun Hou Huang, Phd 2020-12-10
SARS-CoV-2/COVID-19 Prevalence Study Coronavirus disease 19 infection Healthy volunteers accepted, Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) COVID-19 Prevention Network US, Puerto Rico 2020-12-15 2021-03-30 COVPN 5002, NCT04658121 Phase Not Applicable Not yet recruiting 14 3 Months 3920 Ayana Moore, PhD, Jessica Justman, MD, Laura Mkumba 2020-12-10
Impact of Postoperative Telemedicine Visit versus In-person Visit on Patient Satisfaction During the COVID-19 Pandemic: A Prospective, Randomized Trial Coronavirus disease 19 infection Telemedicine visit alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Cedars-Sinai Medical Center US 2020-09-28 2021-06-30 NCT04652674, STUDY00000944 Phase Not Applicable Recruiting 1 9 Months 70 Karen Zaghiyan, MD, Lucille Yao, MD, Phillip Fleshner, MD 2020-12-10
COLDSTER: Comparison of Two Corticosteroid Regimens for Post-COVID Diffuse Lung Disease Coronavirus disease 19 infection, Lung disease, Viral pneumonia prednisolone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Postgraduate Institute of Medical Education and Research India 2020-12-10 2021-12-09 COLDSTER, INT/IEC/2020/SPL-1528, NCT04657484 Phase 2 Clinical Recruiting 0 12 Months 100 Ritesh Agarwal, MD, DM, Sahajal Dhooria, Sahajal Dhooria, MD, DM 2020-12-10
Edtech-HPV: A Community Approach Using Education and Technology to Increase HPV Vaccination Coronavirus disease 19 infection, Papillomavirus infection Text messaging reminder alone, parental HPV vaccine education alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Memorial Sloan-Kettering Cancer Center US 2017-06-28 2022-06-30 17-336, Edtech-HPV, NCT03209713 Phase Not Applicable Recruiting 4 60 Months 800 Abraham Aragones, MD, MS, Ester Corpuz, Eva Moya, PhD, Francesca Gany, MD, MS, Rebeca Aceves Zaragoza 2020-12-10
A clinical trial of peginterferon alfa-2b follow-on-biologic, Zydus-Cadila for the treatment of Coronavirus disease 19 infection Coronavirus disease 19 infection Zydus Cadila Healthcare Ltd US Phase Not Applicable Planned 1 2020-12-09
Reducing Food Insecurity During COVID-19 Coronavirus disease 19 infection Fresh Connect produce prescription program alone, grocery store gift cards alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Boston Medical Center Corp Krupp Family Foundation, Patient Centered Outcome Research Institute, US Department of Agriculture, Waldron Charitable Fund US 2021-01-31 2022-10-31 6007145, H-41052, NCT04652596, PENDING Phase Not Applicable Not yet recruiting 1 21 Months 250 Erin Ashe, MPH, Jocelyn Antonio, BS, Michael Silverstein, MD MPH, Michael Silverstein, MD, MPH 2020-12-09
STOP: Preference-based Tools for Smoking Cessation Among Disadvantaged Smokers, a Pragmatic, Randomized, Controlled Trial Coronavirus disease 19 infection, Nicotine dependence STOP smoking cessation intervention alone, drug prescription alone, e-liquid alone, electronic cigarette alone, free smoking aid delivery alone, nicotine alone, nicotine replacement therapy alone, routine care alone, short didactic video watching alone, smoking cessation advice alone Nicotinic acetylcholine receptor agonist Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Société de Formation Thérapeutique du Généraliste INSERM, National Cancer Institute, France France 2020-12-15 2023-12-15 NCT04654585, STOP, STOP-001 Phase 2 Clinical Not yet recruiting 0 36 Months 528 André Nguyen Van Nhieu, MD, André Soares, MD, Anne Kerharo-Nicolas, MD, Anne-Laurence Le Faou, MD, Anne-Marie Ruppert, MD, Boyer Laurent, MD, Carole Plaussu, MD, Cécile Roche Dominguez, MD, Fabienne El-Khoury, Fabienne El-Khoury Lesueur, PhD, Ghislaine Hacke Mela, MD, Gladys Ibanez, MD, Kebir Oussama, MD, Kinouani Shérazade, MD, Laura Piras, MD, Maria Melchior, PhD, Marion Adler, MD, Mathilde Roze, MD, Michel Cadart, MD 2020-12-15
PRINCESS: Pronation in COVID-19 Patients Undergoing Non Invasive Respiratory Support Coronavirus disease 19 infection, Respiratory failure, Viral pneumonia awake prone position alone, non invasive respiratory support alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Modena and Reggio Emilia Italy 2020-03-01 2020-11-30 NCT04649658, PRINCESS, UMODENAREGGIO10 Phase Not Applicable Completed 0 9 Months 93 Roberto Tonelli 2020-12-16
COVID-RIC1: Seroprevalence Study of CoV-2-SARS (COVID-19) Infection in Patients With Chronic Inflammatory Rheumatic Diseases Coronavirus disease 19 infection, Psoriatic arthritis, Rheumatoid arthritis, Spondylarthritis routine care alone, serological testing alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Montpellier France 2020-12-01 2021-07-30 COVID-RIC1, NCT04655612, RECHMPL20_0624 Phase Not Applicable Recruiting 0 7 Months 5000 Jacques MOREL, MD, PhD, Jacques Morel, MD, PhD, Thao Pham, MD, PhD 2020-12-15
Impact of COVID-19 Pandemic on Out-of-Pocket Costs, Lost Wages, and Unemployment in Patients With Breast Cancer Undergoing Breast Surgery Breast tumor, Coronavirus disease 19 infection mastectomy alone Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) MD Anderson Cancer Center National Cancer Institute US 2019-05-21 2022-03-31 NCI-2019-07463, NCT04169542, PA18-1077 Phase Not Applicable Recruiting 4 34 Months 600 Anaeze Offodile, Elizabeth FitzSullivan, Makesha V. Miggins, Richard A. Ehlers 2020-12-10
Cov-activity: Physical Activity Program Implementation in Hospitalized Positive Covid-19 Older Adults Coronavirus disease 19 infection physical activity program alone Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Toulouse France 2020-11-01 2021-12-31 Cov-activity, NCT04647682, RC31/20/0145 Phase Not Applicable Recruiting 0 14 Months 30 Laurine ANDRE, MD 2020-12-10
SPUTNIK-UAE: A Phase III Clinical Trial of the Immunogenicity and Safety of the Gam-COVID-Vac Vaccine Against COVID-19 in the UAE Coronavirus disease 19 infection Sputnik V alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Gamalei Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation Collaborator PDC-CRO United Arab Emirates, Saudi Arabia 2020-12-31 2021-12-31 06-GAM-COVID-VAC-2020, NCT04656613, SPUTNIK-UAE Phase 3 Clinical Recruiting 0 12 Months 1000 Ahmed Al Hammadi, Mohamed Mostafa 2020-12-10
Addressing Anxiety in 2 to 3-Year Olds: A Pilot, Intervention Study Anxiety disorder, Coronavirus disease 19 infection, Generalized anxiety disorder, Phobia, Social phobia being brave protocol based-cognitive behavioral therapy alone Healthy volunteers accepted, Infants (6-23 months), Preschool Children (2-5 yrs) Massachusetts General Hospital US 2019-09-27 2022-09-01 2018P000376, NCT04039243 Phase Not Applicable Recruiting 1 35 Months 90 Dina Hirshfeld-Becker, PhD, Jordan Holmen, BA 2020-12-10
A case-report study of a newborn infant with congenital factor X deficiency and COVID-19 infection Coronavirus disease 19 infection frozen plasma alone, tranexamic acid alone Female Shahid Beheshti University of Medical Sciences Phase Not Applicable Status not specified 0 1 2020-12-10
COVID-HIGH: HFNT Versus COT in COVID-19 Coronavirus disease 19 infection, Hypoxia, Respiratory failure, Respiratory tract infection, Viral pneumonia High Flow Nasal Therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele Italy 2021-01-10 2022-03-01 1TH DEC 2020, COVID-HIGH, NCT04655638 Phase Not Applicable Not yet recruiting 0 13 Months 364 Alberto Noto, Alessio Mattei, Andrea Cortegiani, Andrea Cortegiani, MD, Annalisa Carlucci, Antonino Giarratano, Cesare Gregoretti, Claudia Crimi, Claudia Crimi, MD, Enrico Clini, Nicola Scichilone, Raffaele Scala 2020-12-09
Effectiveness of ICU diaries on satisfaction of family members of COVID-19 patients in the ICU Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Sapporo Medical University School of Medicine Japan 2020-09-01 UMIN000042681 Phase Not Applicable No longer recruiting 0 4 JUNPEI HARUNA 2020-12-08
MAPPING-V: Malaysian Public Preferences and Willingness to pay for Covid-19 Vaccination: A Discrete Choice Experiment Coronavirus disease 19 infection Covid-19 Vaccine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Institutes of Health Malaysia Malaysia 2021-01-01 2021-12-31 57377, MAPPING-V, NMRR-20-2633-57377 Phase Not Applicable Not yet recruiting 0 12 Months MISS TEH HOON SHIEN 2020-12-11
nCoV-19 in elderly Coronavirus disease 19 infection Healthy volunteers accepted Hospital Kuala Lumpur Malaysia 2020-04-24 2020-05-24 54825, NMRR-20-2620-54825 Phase Not Applicable Status not specified 0 1 Month Dr Lee Yoong Wah 2020-12-11
RLX0120: Trial to study efficacy and safety of two doses of raloxifene in adult paucisymptomatic COVID-19 patients Coronavirus disease 19 infection raloxifene alone Estrogen receptor modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dompe Farmaceutici SpA Italy 2020-10-31 2020-003936-25, RLX0120, RLX0120 Phase 2/Phase 3 Clinical Recruiting 1 150 Flavio Mantelli 2020-12-09
Physical Activity During Covid-19 Lockdown Coronavirus disease 19 infection Physical Activity alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Tengku Ampuan Afzan, University Malaya Medical Centre Malaysia 2020-12-02 2021-03-17 55434, NMRR-20-2607-55434 Phase Not Applicable Status not specified 2 3 Months Dr Lim Zhuang Li, Dr. Choong Wai Kwong 2020-12-08
Phase II/III Study of COVID-19 DNA Vaccine (AG-0302-COVID19) Coronavirus disease 19 infection AG-0301-COVID19 alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AnGes MG Inc Japan Agency for Medical Research and Development Japan 2020-11-23 2022-03-31 AG0302-COVID19-JN-02, NCT04655625 Phase 2/Phase 3 Clinical Recruiting 0 16 Months 500 AnGes, Inc. Clinical Development 2020-12-16
COVID-VAC: Factors Influencing the Potential Acceptance of a Covid-19 Vaccine Among Healthcare Workers in a District Hosipital in Manjung, Perak Coronavirus disease 19 infection COVID-19 vaccine alone Healthy volunteers accepted HOSPITAL SERI MANJUNG Malaysia 2020-12-07 2021-01-31 57315, COVID-VAC, NMRR-20-2589-57315 Phase Not Applicable Not yet recruiting 0 1 Month 384 Chiew Shoen Chuen, Dr Lee Li Yuan 2020-12-11
COVID-19 Outbreak Management Coronavirus disease 19 infection JABATAN KESIHATAN NEGERI TERENGGANU Malaysia 2020-12-15 2021-02-28 56487, NMRR-20-2584-56487 Phase Not Applicable Status not specified 0 2 Months AHMAD FUAD BIN OMAR, Dr Goh Soo Ning 2020-12-11
COVIDEYE: Prevalence of SARS-CoV-2 Genome in Tears of Asymptomatic and Moderately Symptomatic COVID-19 Patients Coronavirus disease 19 infection PCR alone, conjunctival swab test alone, nasopharyngeal swab test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assistance Publique Hopitaux de Paris France 2020-12-31 2021-12-31 2020-A02996-33, APHP201268, COVIDEYE, NCT04654325 Phase Not Applicable Not yet recruiting 1 12 Months 1280 Antoine ROUSSEAU, PhD, Antoine Rousseau, PhD, Christelle Vauloup-Fellous, PhD 2020-12-09
Efficacy of prebiotic products on admitted patients with Covid-19 Coronavirus disease 19 infection probiotic intake alone, hydroxychloroquine plus remdesivir COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator Shaheed Beheshti Medical University Iran 2020-09-22 IR.SBMU.RETECH.REC.1399.562, IRCT20161206031255N4 Phase 3 Clinical Recruiting 1 60 Afshin Zerghi, Roshanak Mokaberinejad 2020-12-09
Bromhexine hydrochloride for prophylaxis against COVID-19 Coronavirus disease 19 infection bromhexine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-08-22 IR.SBMU.PHARMACY.REC.1399.247, IRCT20120703010178N22 Phase 3 Clinical Recruiting 0 1050 Hassan Yazdan Panah, Mohammad Sistanizad, Omid Moradi, Shadi Ziaie 2020-12-08
A clinical study of new scanning technique, dubbed the Xenon technique, to identify lung damage caused by COVID-19 Coronavirus disease 19 infection, Lung injury Xenon technique scan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University of Oxford US Phase Not Applicable Recruiting 1 10 Professor Fergus Gleeson 2020-12-12
Clinical Outcome of Patients With COVID-19 Pneumonia Treated With Corticosteroids and Colchicine Coronavirus disease 19 infection, Viral pneumonia dexamethasone alone, colchicine plus dexamethasone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clínica Medellín - Comprometidos con tu Salud Colombia 2020-03-20 2020-08-20 04-2020, NCT04654416 Phase Not Applicable Completed 1 5 Months 301 Miguel Alejandro Pinzón 2020-12-09
COMMUNITY: An adaptive, randomized, double-blind, placebo-controlled platform study designed to assess multiple candidates as a potential treatment for hospitalized patients with COVID-19 Coronavirus disease 19 infection multiple therapeutic candidates  alone, standard of care alone Amgen Inc, Takeda Pharmaceutical Co Ltd, UCB SA 2020-11-30 COMMUNITY Phase Not Applicable Recruiting 0 2020-12-12
A multi-center, double-blind, placebo-controlled, adaptive design, phase III clinical trial to evaluate the efficacy and safety of fostamatinib in adult, hospitalized COVID-19 patients Coronavirus disease 19 infection fostamatinib disodium alone Syk tyrosine kinase inhibitor Rigel Pharmaceuticals Inc 2020-12-31 Phase 3 Clinical Planned 0 2020-12-08
Prevalence of burnout, its associated factors among Dr and nurse of JB DHO during COVID-19 pandemic Coronavirus disease 19 infection Healthy volunteers accepted Universiti Sains Malaysia Malaysia 2021-01-01 2021-05-31 57271, NMRR-20-2579-57271 Phase Not Applicable Not yet recruiting 1 5 Months Dr NUR SUJAIHAH BINTI HANAFI 2020-12-09
A large-scale surveillance study of OneDraw Blood Collection Device to assess the prevalence of previous infection with COVID-19 Coronavirus disease 19 infection OneDraw device alone Drawbridge Health Inc, University of Cambridge UK Phase Not Applicable Recruiting 1 4000 Professor Nick Wareham 2020-12-08
Awareness, Knowledge and Attitudes of Obstetricians towards the use of Telemedicine in Antenatal Care: A Cross-sectional study in a Tertiary Government Hospital in the Philippines during the COVID-19 Pandemic Coronavirus disease 19 infection Telemedicine alone Philippine General Hospital Philippines 2020-10-20 2020-11-30 PHRR201201-003180 Phase Not Applicable Completed 1 1 Month Dominique Joyce M. Concepcion, Izabelle Julienne Figueras-Prieto, Regina Rosario M. Panlilio 2020-12-08
COVID-19 Cure Using Integrative Treatment Coronavirus disease 19 infection PAK-20 consumption alone, ajwa dates seed powder intake alone, integrative treatment intervention alone, kalonji intake alone, meat/ lentil intake alone, oniater intake alone, talbina intake alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Knowledge Research and Innovation Center, Iran, Pakistan 2020-01-17 2020-07-01 ChiCTR2000040632, IRCT20200823048495N1, KRIC/REC/1/01 Phase 1 Clinical Completed 2 5 Months 34 Muhammad Anwar Masood Behr, Muhammad Yahya Qureshi, Umber Nawaz 2020-12-14
Treatment With Pirfenidone for COVID-19 Related Severe ARDS Coronavirus disease 19 infection, Respiratory distress syndrome pirfenidone alone, standard of care alone PDGF receptor antagonist, TGF beta receptor antagonist, p38 MAP kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Soroka University Medical Center Roche Holding AG Israel 2020-11-08 2021-12-31 NCT04653831, SCRC20007 Phase 2 Clinical Recruiting 1 13 Months 100 Ori Galante, MD, Yasmeen Abu Fraiha, Yasmeen Abu Fraiha, MD 2020-12-09
Efficacy of barley water (Hordeum vulgare) in clinical outcome of COVID-19 patients Coronavirus disease 19 infection, Viral pneumonia barley water intake alone, current medication alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shiraz University of Medical Sciences Iran 2020-11-15 IR.SUMS.REC.1399.216, IRCT20150830023823N3 Phase 3 Clinical No longer recruiting 1 50 Abbas Rezaianzadeh, Ali Tavakoli 2020-12-18
To compare the effect of lying in face down position along with oxygen therapy given through high-flow nasal cannula device versus lying face down with oxygen given by non-rebreathing face mask in COVID-19 patients Coronavirus disease 19 infection, Hypoxia, Respiratory failure awake prone positioning alone, high-flow nasal cannula alone, oxygen alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences Patna India 2020-12-15 CTRI/2020/12/029587 Phase 2 Clinical Not yet recruiting 1 60 Rajnish Kumar 2020-12-09
Effects of PPE among Healthcare Workers Coronavirus disease 19 infection, Psychiatric disorder personal protective equipment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sri Ramachandra Medical College, Hospital & Research institute Sri Ramachandra University India 2020-12-15 CTRI/2020/12/029584 Phase Not Applicable Not yet recruiting 1 150 Dr Swathy Moorthy, DrSPThiagarajan 2020-12-07
CADE: Cardiac Assessment After Covid-19 Disease in Elite Altheltic Population Coronavirus disease 19 infection, Heart injury MRI alone, echocardiography alone, electrocardiogram alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) University Hospital, Montpellier Centre Hospitalier Universitaire de Nimes, Centre Hospitalier de Perpignan, Clinique du Millénaire, Rennes University Hospital, ligue nationale de Basket France 2020-04-01 2021-01-01 CADE, NCT04653857, RECHMPL20_0648 Phase Not Applicable No longer recruiting 1 9 Months 250 Christophe HEDON, MD, Stéphane CADE, MD 2020-12-09
Effectiveness of Unani add-on therapy in preventing the disease severity of COVID-19 infection Coronavirus disease 19 infection Variable regimens including Behidana, Unnab and Sapistan-unani decoction , Joshanda tea , Tiryaq-e-Arba , azithromycin , hydroxychloroquine , vitamin C , zinc Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Central Council for Research in Unani Medicine Ministry of Ayush India 2020-12-04 CTRI/2020/12/029575 Phase 3 Clinical Not yet recruiting 1 100 Dr Jugal Kishore, Dr Rohit Kumar, Dr Tamanna Nazli, Prof Jugal Kishore 2020-12-09
Study of the safety of hyperimmune bovine milk and colostrum against COVID-19 Coronavirus disease 19 infection bovine Colostrum plus bovine milk Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Isfahan University Isfahan Oil Refinery Iran 2020-11-10 2020-11-25 IR.MUI.MED.REC.1399.672, IRCT20200927048849N1 Phase 1 Clinical Completed 1 40 Hassan Niliahmadabadi, Rasoul Roknizadeh, Somayeh Sadeghi 2020-12-08
A study of cyclophosphamide outcomes in patients with COVID-19 Coronavirus disease 19 infection, End stage renal disease, Respiratory distress syndrome, Vasculitis cyclophosphamide plus prednisone Metropolitan Hospital Center Phase Not Applicable Status not specified 0 3 2020-12-07
GraphealNpas: Feasibility and Analytical Performance of TestNPass (IVDMD) for COVID-19 Diagnosis on Saliva Sample Coronavirus disease 19 infection TestNPass diagnotic medical device (Grapheal SAS) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital, Grenoble Grapheal SAS France 2020-12-15 2021-03-15 2020-A03087-32, 38RC20.378, GraphealNpas, NCT04654442 Phase Not Applicable Not yet recruiting 1 3 Months 60 Benjamin Némoz, MD, Benjamin Némoz, Némoz, Marion Le Maréchal, MD, Pierre AUDOIN, MS 2020-12-09
NIVHOC: A clinical trial to compare the effect of non-invasive ventilation with high-flow nasal oxygen therapy versus only high flow nasal oxygen therapy in COVID 19 patients with respiratory failure Coronavirus disease 19 infection, Respiratory failure face mask alone, non-invasive ventilation based high flow nasal oxygen therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) All India Institute of Medical Sciences Patna India 2020-12-12 CTRI/2020/12/029585, NIVHOC Phase Not Applicable Not yet recruiting 1 100 Kunal Singh 2020-12-09
ROCD: A study of kidney Problems with covid 19 in admitted patients at a teritiary care hospital Coronavirus disease 19 infection, Renal disease Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Yenepoya Medical college India 2020-12-21 CTRI/2020/12/029581, ROCD Phase Not Applicable Not yet recruiting 1 300 Dr Santhosh Pai, Dr Santhosh pai 2020-12-09
Various Blood Parameters Affecting outcome in ICU Patients Coronavirus disease 19 infection, Vitamin D deficiency Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) JSS University India 2020-12-15 CTRI/2020/12/029586 Phase Not Applicable Not yet recruiting 1 150 DR AKSHAY, DR Rajalakshmi R 2020-12-09
Aerosol Particle Concentrations Among Different Oxygen Devices for Spontaneous Breathing Patients With Tracheostomy Coronavirus disease 19 infection, Respiratory disease Airvo2 (Fisher and Paykel Healthcare Ltd) alone, high-flow high humidity oxygen therapy alone, tracheostomy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rush University Medical Center US 2021-01-31 2021-05-31 HFOT-TRACH-AEROSOL, NCT04654754 Phase Not Applicable Not yet recruiting 1 4 Months 10 Jie Li, Jie Li, PhD 2020-12-07
Study of AffloVest in At-Risk Respiratory Patients During COVID-19 Pandemic Chronic obstructive pulmonary disease, Coronavirus disease 19 infection, Cough Afflovest device alone, Standard Care alone, digital thermometer alone, high frequency chest wall oscillation (HFCWO) therapy alone, pulse oximeter alone, spirometer alone, telehealth training alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mount Sinai Medical Center International Biophysics Corporation, SPARK Healthcare US 2020-12-31 2021-11-30 GCO 20-2667, ISMMS-AFF-20, NCT04654481 Phase Not Applicable Recruiting 1 11 Months 30 Elinor L Schwind, MS, Patricia Walker, MD, Teresa Demarco, PTA 2020-12-09
Serial sero-epidemiological surveillance study to monitor the trend of SARS-CoV-2, Dengue and Chikungunya infection transmission in the Vellore Demographic Health Surveillance System (HDSS) Chikungunya virus infection, Coronavirus disease 19 infection, Dengue virus infection neutralization assay alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Christian Medical College, Vellore, India Biotechnology Industry Research Assistance Council, National BioPharma Mission India 2020-12-10 CTRI/2020/12/029564 Phase Not Applicable Not yet recruiting 1 5000 Winsley Rose 2020-12-08
ReCOV: RT-PCR Database Analysis for COVID-19 Infections and Re-infection Coronavirus disease 19 infection RT-PCR alone University Hospital, Montpellier Centre Hospitalier Universitaire de Nimes, Centre National de la Recherche Scientifique (CNRS), Laboratoire Pasteur-Cerba, MIVEGEC, MPL Analysis Laboratoires France 2020-02-01 2021-03-30 NCT04653844, RECHMPL20_0640, ReCOV Phase Not Applicable No longer recruiting 1 13 Months 7000000 Vincent Foulongne, PhD 2020-12-09
A case report study of severe encephalopathy or focal brain lesions in children with multisystem inflammatory syndrome associated with COVID-19 Brain disease, Coronavirus disease 19 infection, Inflammatory disease Variable regimens including IV immunoglobulin , anakinra , methylprednisolone Type I IL-1 receptor antagonist Male, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Columbia University Irving Medical Center Phase Not Applicable Status not specified 0 1 2020-12-07
AtemNHK: Effects of Integrative Medicine on Infectious Respiratory Diseases Including COVID-19 Coronavirus disease 19 infection, Respiratory tract infection protective lifestyle intervention alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Charite University Germany 2020-12-31 2021-12-31 ATEMNHK, AtemNHK, NCT04653727 Phase Not Applicable Not yet recruiting 1 12 Months 3000 Andreas Michalsen 2020-12-09
Evaluation of prophylaxis induced by ivermectin in populations exposed to COVID-19 patients Coronavirus disease 19 infection ivermectin alone Chloride channel modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Akam Tejarat Fartak Farasoo Iran 2020-11-30 IR.QUMS.REC.1399.261, IRCT20200408046987N3 Phase 3 Clinical Recruiting 3 800 Abbas Allami, Alireza Mehralian, Morteza Shakhsi Niaee, Nematollah Gheibi, fatemeh samieerad 2020-12-08
Effect of GRAPEX in treatment of COVID-19 Coronavirus disease 19 infection Grapex alone, Standard country protocol drug therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Abadan University of Medical Sciences Iran 2021-01-08 IR.ABADANUMS.REC.1399.098, IRCT20200921048783N1 Phase 3 Clinical Not yet recruiting 1 80 Hoda Mojiri-Forushani, Hoda Mojjiri-Forushani, Sara Mobarak 2020-12-08
A phase II study to evaluate PIC1-01 for the treatment of patients with hypoxic ischemic encephalopathy (HIE) Brain hypoxia-ischemia, Coronavirus disease 19 infection PIC1-01 alone Complement C1s subcomponent inhibitor ReAlta Life Sciences Inc Europe Phase 2 Clinical Planned 0 2020-12-07
The effect of Helichrysum pseudoplicatum syrup on clinical manifestations of patients with COVID-19 Coronavirus disease 19 infection, Respiratory tract infection Helichrysum pseudoplicatum syrup (Shahid Beheshti, Arak University of Medical Sciences) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Arak University of Medical Sciences and Health Services Iran 2020-05-18 IR.ARAKMU.REC.1399.003, IRCT20180610040049N6 Phase 3 Clinical No longer recruiting 1 60 Alireza Kamali, Hosein Sarmadian, Mohammad KamaliNejad, Seied Amirhosein Latifi 2020-12-08
A pivotal, phase II/III clinical trial to evaluate SCB-2019 in combination with Dynavax’s advanced CpG 1018 adjuvant plus alum for the prevention of SARS-CoV-2 infection Coronavirus disease 19 infection Variable regimens including CpG 1018 adjuvant , SCB-2019 , alum COVID19 Spike glycoprotein modulator Clover Biopharmaceuticals AUS Pty Ltd 2021-06-30 Phase 2/Phase 3 Clinical Planned 0 2020-12-07
Serological investigations of blood donors from the city and area around Magdeburg for antibodies against SARS-CoV-2 (COVID-19) Coronavirus disease 19 infection serological examination alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Institut fUr Medizinische Mikrobiologie und Krankenhaushygiene Institut fur Sozialmedizin und Gesundheitssystemforschung, Ministerium für Wirtschaft, Wissenschaft und Digitalisierung des Landes Sachsen-Anhalt Germany 2021-01-15 163/20, DRKS00023263 Phase 4 Clinical Not yet recruiting 1 4500 Heuft Hans-Gert, Stephan Kramer 2020-12-08
A retrospective, case series study to describe clinical outcomes associated with tocilizumab compared with those not receiving tocilizumab in critically ill patients with severe COVID-19 Coronavirus disease 19 infection tocilizumab alone Atrium Health Phase Not Applicable Status not specified 0 49 2020-12-07
A follow-up study of long-term prognosis in patients with novel coronavirus pneumonia (COVID-19) Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Xi'an Children's Hospital China 2020-02-02 2021-05-31 ChiCTR2000040628 Phase Not Applicable Recruiting 1 15 Months 430 Guo Yaling, Xu You, Yang Mingb, Yang Puye 2020-12-07
Novel coronavirus pneumonia (COVID-19) treated with different antiviral regimens: a medical records based study for analysis of therapeutic effect and length of stay of hospitalization Coronavirus disease 19 infection hormone therapy alone, Variable regimens including Lianhua Qingwen , abidol , interferon , oseltamivir , ribavirin Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) People's Hospital of Shapingba District, Chongqing City China 2020-12-01 2022-11-30 2020SQKWLH016, ChiCTR2000040571 Phase Not Applicable Not yet recruiting 1 24 Months 180 Huang Zi Yang 2020-12-07
Impact of COVID-19 pandemic on post graduate medical trainees in India Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Post Graduate Institute of Dental Sciences (PGIMS) India 2020-12-06 BREC/20/204, CTRI/2020/12/029515 Phase Not Applicable Not yet recruiting 1 1000 Jyoti Khanna 2020-12-07
An exploratory, phase II, physician-initiated clinical trial investigating the efficacy and safety of TM-5614 in patients with novel coronavirus pneumonia Coronavirus disease 19 infection, Viral pneumonia TM-5614 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japan Agency for Medical Research and Development Japan 2020-07-20 2021-01-31 jRCT2021200018 Phase 2 Clinical Recruiting 1 6 Months 30 Fumio Sakamaki, Harigae Hideo, Hideo Zhang, Hisatoshi Sugiura, Isao Ito, Keisuke Tomii, Koichiro Asano, Sakurako Tajiri, Yasunari Miyazaki 2020-12-07
MeDiCo- health Study: Eating habits during the Covid-19 pandemic Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Technical University of Munich EIT Food iVZW, Personalized nutrition and vitamins - LOEWI Germany 2020-12-03 655/20 S, DRKS00022514, MeDiCo- health Study Phase Not Applicable Not yet recruiting 1 200 Laura Mengel, Thomas Skurk 2020-12-07
CHDR2044: Healthy volunteers blood sampling Coronavirus disease 19 infection flow cytometry alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Leyden Laboratories BV Netherlands 2020-11-03 2021-01-31 CHDR2044, NL75505.058.20, NL9045 Phase Not Applicable Not yet recruiting 1 2 Months 20 I.M.C. de Visser-Kamerling 2020-12-08
DF in COVID19: A Single-Arm Safety and Feasibility Study of Defibrotide for the Treatment of Severe COVID-19 Coronavirus disease 19 infection, Viral pneumonia defibrotide (iv, veno-occlusive disease), Gentium alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Brigham & Women's Hospital Jazz Pharmaceuticals plc US 2021-01-01 2023-11-01 2020P003203, DF in COVID19, NCT04652115 Phase 2 Clinical Not yet recruiting 1 34 Months 42 Paul G Richardson, MD, Paul G. Richardson 2020-12-08
Exploratory research on severity indicators for COVID-19 patients Coronavirus disease 19 infection, Viral pneumonia Body motion sensor alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Japan Agency for Medical Research and Development Japan 2020-07-30 2020-12-31 jRCT1052200041 Phase Not Applicable Not yet recruiting 1 5 Months 40 Eiji Asanoi, Naho Fujiwara, Shigeru Miyagawa, Sho Saito, Yoshiki Sawa, Yukio Abe, sawa Yoshiki 2020-12-07
Effect of the COVID-19 Public Health Crisis on the Mental Health and Physical Well-Being of Cancer Patients, the Coping With COVID Study Acute stress disorder, Coronavirus disease 19 infection, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) MD Anderson Cancer Center National Cancer Institute US 2020-07-13 2021-03-31 2020-0451, NCI-2020-06556, NCT04652505 Phase Not Applicable Recruiting 1 8 Months 700 Tamara E Lacourt, Tamara E. Lacourt 2020-12-08
CoronaVac3CL: Efficacy, Safety, and Immunogenicity of an Inactivated Vaccine Against COVID-19 in High Infection Risk Adults Coronavirus disease 19 infection CoronaVac alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Pontificia Universidad Catolica De Chile Ministry of Health, Sinovac Research & Development Co Ltd Chile 2020-11-27 2022-03-31 200708006, CoronaVac3CL, NCT04651790 Phase 3 Clinical Recruiting 1 16 Months 2300 Alvaro Rojas, MD, Carolina Iturriaga, Nurse, Katia Abarca, MD, María Soledad Navarrete, Nurse 2020-12-09
An observational, single-center study to evaluate the prevalence of major bleeding events in patients with COVID-19 receiving intensive thromboprophylaxis Bleeding, Coronavirus disease 19 infection enoxaparin alone, heparin alone Università della Svizzera italiana Switzerland Phase Not Applicable Status not specified 1 270 2020-12-04
WAYRA: Home-based Respiratory Physiotherapy and Telephone-Based Psychological Support in Severe COVID-19 Patients Coronavirus disease 19 infection home-based respiratory physiotherapy alone, telephone-based psychological support alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Universidad Peruana Cayetano Heredia Johns Hopkins University, London School of Hygiene and Tropical Medicine Peru 2020-10-26 2021-03-30 202852, NCT04649736, WAYRA Phase Not Applicable Recruiting 1 5 Months 108 Anderson N. Soriano-Moreno, MD, Andres G Lescano, PhD, MHS, Germán Málaga, MD, MSc, Stella M Hartinger, MSc, PhD, William Checkley, MD, PhD 2020-12-07
CovExc: Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection Coronavirus disease 19 infection rehabilitation by eccentric exercises alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Clermont-Ferrand GIRCI Auvergne Rhône-Alpes, Ministry of Health, France France 2020-06-05 2021-12-05 2020-A01201-38, CovExc, NCT04649086, PHRCI 2020 COSTE (COVEXC) Phase Not Applicable Recruiting 5 18 Months 120 Dominic PERENNOU, MD, PhD, Emmanuel COUDEYRE, MD, PhD, Emmanuelle CHALEAT-VALAYER, MD, PhD, Lise Laclautre, PharmD, Léonard FEASSON, MD, PhD, Nicolas COSTE, MD, MSc, Paul ORNETTI, MD, PhD 2020-12-07
Packaging and Disseminating the JOIN for ME Program in Low-Income Settings Coronavirus disease 19 infection, Obesity JOIN for ME program alone Healthy volunteers accepted, Children (6-12 yrs) Miriam Hospital Brandeis University, Brown University, Tufts University, University of North Carolina US 2021-01-31 2023-02-28 5U18DP006429-02, NCT04647760 Phase Not Applicable Not yet recruiting 1 25 Months 128 Andrea M Grenga, BA, Elissa Jelalian, PhD 2020-12-07
SHYCOV: Silent Hypoxia and Awake Proning in COVID-19 Patients Coronavirus disease 19 infection, Hypoxia physiotherapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ostfold Hospital Trust Norway 2020-11-30 2021-12-31 NCT04647747, SHYCOV, SHYCOV2020 Phase Not Applicable Not yet recruiting 1 13 Months 40 Hans Joakim Myklebust-Hansen 2020-12-07
Rapid Development and Implementation of a Remote ECG-monitored, Prospective, Randomized Clinical Trial During a Pandemic: Hydroxychloroquine Prophylaxis in COVID-19 Household Contacts Coronavirus disease 19 infection hydroxychloroquine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Bryn Mawr Hospital Sharpe-Strumia Foundation US 2020-05-27 2020-11-15 BM02332, NCT04652648 Phase 4 Clinical Completed 3 5 Months 54 Luciano kapelusznik 2020-12-07
PCR Cycle Threshold Values and COVID-19 Outcomes Coronavirus disease 19 infection real-time polymerase chain reaction alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospitals of North Midlands NHS Trust UK 2020-11-24 2021-03-31 286389, NCT04651413 Phase Not Applicable Recruiting 1 4 Months 800 Keira Watts, Robert Bowler, Robert J Bowler, Timothy Kemp 2020-12-08
The Protective Potential of Exercise Training on the Cardiopulmonary Morbidity After COVID-19 Coronavirus disease 19 infection high intensity interval training alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rigshospitalet Denmark 2021-01-01 2021-12-31 H-20033733 V.2, NCT04647734 Phase Not Applicable Not yet recruiting 1 12 Months 40 Regitse Christensen, MD, PhD, Ronan Berg, DMSc, MD 2020-12-08
COMBO: Camostat With Bicalutamide for COVID-19 Coronavirus disease 19 infection Standard of care alone, camostat mesylate alone, bicalutamide plus camostat mesylate Androgen receptor antagonist, Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sidney Kimmel Comprehensive Cancer Center US 2021-01-31 2023-01-31 COMBO, COV2005, IRB00254142, NCT04652765 Phase 1 Clinical Not yet recruiting 1 24 Months 60 Aliya Lalji, MD, Catherine H Marshall, MD/MPH 2020-12-08
LYT-100 in Post-acute COVID-19 Respiratory Disease Coronavirus disease 19 infection, Fibrosis, Inflammatory disease, Viral pneumonia deupirfenidone alone PDGF receptor antagonist, TGF beta receptor antagonist, p38 MAP kinase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) PureTech Health Plc Clinipace Worldwide, Novotech (Australia) Pty Ltd Romania, US 2020-12-11 2021-12-31 LYT-100-2020-02, NCT04652518 Phase 2 Clinical Recruiting 3 12 Months 168 Adrian Streinu-Cercel, MD, PhD, Barry Sigal, MD, FCCP, Heather Paden, Jack Bissett, MD, Site Coordinator, Toby Maher, MD 2020-12-17
Testing the effectiveness of almitrine bismesylate in the treatment of COVID-19 Coronavirus disease 19 infection, Hypoxia, Viral pneumonia almitrine bismesylate alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Oxford LifeArc UK 2020-04-30 2021-09-30 2020-002567-57, CPMS 47241, IRAS 282381, ISRCTN11713182 Phase 2 Clinical Recruiting 3 17 Months 116 Dr Talbot 2020-12-08
FSC19-KN: Single-Center, Prospective, Controlled, Follow-up Study of COVID-19 Patients District Konstanz Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hegau-Bodensee-Klinikum Deutsche Forschungsgemeinschaft (DFG), German Federal Ministry of Education and Research Germany 2021-01-01 20-1020, DRKS00022409, FSC19-KN Phase Not Applicable Not yet recruiting 1 400 Marc Kollum 2020-12-08
Observational, Retrospective Study to Evaluate Coagulation Changes and the Influence of Antithrombin III Treatment in Patients With Severe COVID-19 Infection Blood clotting disorder, Coronavirus disease 19 infection antithrombin III alone Octapharma AG Austria, France, Germany 2020-10-19 2021-01-31 ATN01, NCT04651400 Phase Not Applicable Recruiting 5 3 Months 300 Mikaela Raymond 2020-12-08
A retrospective study to evaluate the effects of tocilizumab in the treatment of critical COVID-19 pneumonia Coronavirus disease 19 infection, Pneumonia Mechanical ventilation alone, tocilizumab alone, Variable regimens including Standard hospital protocol Stony Brook University Hospital US Phase Not Applicable Status not specified 1 115 2020-12-04
HOO-COVID: Efficacy and Safety of Ozonized Oil (HOO) in COVID-19 Patients Coronavirus disease 19 infection ozonized oil alone, routine standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto Neurologico Mediterraneo NEUROMED Italy 2021-01-31 2021-08-31 DEP_052020, HOO-COVID, NCT04651387 Phase Not Applicable Not yet recruiting 1 7 Months 74 Licia Iacoviello, MD, PhD 2020-12-07
CAGE: COVID-19 And geko Evaluation Coronavirus disease 19 infection geko T3 device alone, peroneal nerve neuromuscular electrical stimulation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lawson Health Research Institute Canada 2020-12-31 2021-04-30 CAGE, ISS-COV-002, NCT04651374 Phase Not Applicable Not yet recruiting 1 4 Months 40 Jessica Sturt-Smith, Tina Mele, Tina Mele, MD PhD FRCSC 2020-12-07
A retrospective, observational study to evaluate the treatment responses of criteria-based tocilizumab therapy for COVID-19 respiratory infection in ICU and non-ICU patients Coronavirus disease 19 infection, Respiratory tract infection tocilizumab alone Jefferson Health (US) Phase Not Applicable Status not specified 0 170 2020-12-04
A study to evaluate the efficacy of DeepCOVID-XR, the machine-learning algorithm, to detect COVID-19 by analyzing X-ray images of the lungs Coronavirus disease 19 infection DeepCOVID-XR alone Northwestern University US Phase Not Applicable Status not specified 1 2020-12-04
Safety and Immunogenicity of SARS-CoV-2 mRNA Vaccine (BNT-162b2) in Chinese Healthy Population Coronavirus disease 19 infection, Viral pneumonia BNT-162b2 alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over), Asian Ancestry BioNTech SE, Jiangsu Province Centers for Disease Control and Prevention Shanghai Fosun Pharmaceutical Industry Development Co Ltd China 2020-11-25 2021-12-31 BNT162-06, ChiCTR2000040044, NCT04649021 Phase 2 Clinical Recruiting 5 13 Months 960 BioNTech Responsible Person, BioNTech clinical trial information desk, Wang Wei, Zhu Fengcai 2020-12-15
Serological Profile of Children and Young Adolescents With at Least One COVID-19 Diagnosed Family Member Coronavirus disease 19 infection Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universita degli Studi di Milano Italy 2020-12-05 2021-12-31 GMT_CD_CT_LG_EB_10_2020, NCT04649944 Phase Not Applicable Not yet recruiting 1 12 Months 40 Giampietro Farronato, DDS, Gianluca Martino Tartaglia, DDS PhD, Gianluca Tartaglia, Professor, Marco Farronato, 2020-12-08
The effect of Steroid on the outpatient treatment of COVID-19 Coronavirus disease 19 infection prednisolone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Isfahan University of medical Sciences Iran 2020-12-21 IR.MUI.MED.REC.1399.781, IRCT20171219037964N2 Phase 3 Clinical Not yet recruiting 3 70 Babak Amra, Dr. Babak Amra, Dr. Forough Soltaninejad, Dr. Mehrdad Salahi, Shaghayegh Haghjoo 2020-12-08
SAVID: Serum Amyloid A as a prognostic marker for disease severity and mortality in COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Franciscus Gasthuis & Vlietland Siemens Healthcare GmbH Netherlands 2021-01-01 2021-12-31 NL9082, SAVID Phase Not Applicable Planned 1 12 Months 400 Nadine Pouw 2020-12-07
High-Flow Nasal Cannula for severe COVID-19, a multicenter, prospective, cohort study Coronavirus disease 19 infection High-Flow Nasal Cannula alone Franciscus Gasthuis & Vlietland 2020-12-01 2021-12-31 NL9067 Phase Not Applicable Planned 0 13 Months 200 Yasemin Türk 2020-12-04
SHARP-COVID: COVID-19 pandemic impact on severe asthma patients care in Europe Asthma, Coronavirus disease 19 infection Amsterdam University Medical Center Netherlands 2020-11-22 2021-01-31 NL9063, SHARP-COVID Phase Not Applicable Not yet recruiting 1 2 Months 900 Katrien Eger 2020-12-04
Estimation of Dynamics of Humoral and Cellular Immunity in COVID-19 Patients Coronavirus disease 19 infection, Viral pneumonia Humoral and cellular immunity test alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus Belarusian State Medical University, Belarussian Research Institute for Epidemiology and Microbiology Belarus 2020-10-01 2021-12-31 IBCE-COVID19-IMMUNITY, NCT04649840 Phase Not Applicable Recruiting 1 15 Months 60 Andrei Hancharou, MD, PHD 2020-12-04
A retrospective study on clinical outcome of tocilizumab in relation to respiratory status improvements and to analyze the association between initial inflammatory markers and treatment outcomes in patients with COVID-19 Coronavirus disease 19 infection tocilizumab alone Saint Barnabas Health Care Systems Phase Not Applicable Status not specified 0 84 2020-12-09
The Impact of COVID-19 on Surgical Practice in Jordan During the Second Outbreak Coronavirus disease 19 infection Yarmouk University Jordan 2020-11-01 2020-11-10 NCT04650035, THE IMPACT OF COVID-19 JORDAN Phase Not Applicable Completed 1 60 Raed M Ennab 2020-12-04
VR Baby, a virtual reality learning environment - does it help medical students to learn about complex topics in obstetrics and gynecology? Coronavirus disease 19 infection Brightspace eLearning University platform alone, VR Baby virtual reality learning environment intervention alone Healthy volunteers accepted University College Dublin Ireland 2020-01-27 2021-03-31 ISRCTN19845486 Phase Not Applicable No longer recruiting 1 14 Months 40 Prof Fionnuala McAuliffe 2020-12-08
AirFLO2 Treatment for Hypoxia and/or Tachypnea in Patients With COVID-19 (AirFLO2) Coronavirus disease 19 infection, Hypoxia, Tachypnea AirFLO2 device alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Duke University Medex Inc US 2020-12-04 2021-06-30 NCT04649775, PRO00105246 Phase Not Applicable Not yet recruiting 1 6 Months 50 Catherine M Foss, BS, Loretta Que, MD, Maria A Santoro, MA 2020-12-04
Early@home Coronavirus disease 19 infection, Viral pneumonia oxygen therapy alone, telemonitoring alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universiteit Utrecht Netherlands 2021-01-11 2021-05-31 NL9081, TBA Phase Not Applicable Not yet recruiting 0 4 Months 100 Harriët van Goor 2020-12-11
Prolonged grief disorder due to the Covid-19 lockdown? - Impact of contact restrictions on the relatives of patients who died during lockdown Anxiety disorder, Coronavirus disease 19 infection, Depression, Psychiatric disorder Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Gießen and Marburg Germany 2020-12-02 178/20, DRKS00023713 Phase Not Applicable Recruiting 0 567 Mr. Dr. med. Christian Volberg 2020-12-11
SOLIDARITY: WHO COVID-19 Solidarity Trial for COVID-19 Treatments Coronavirus disease 19 infection acalabrutinib alone, interferon beta-1a alone, remdesivir alone Btk tyrosine kinase inhibitor, COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of The West Indies-Mona Jamaica 2020-12-01 2021-12-31 NCT04647669, SOLIDARITY, SRD/ETH/20 Phase 3 Clinical Not yet recruiting 1 13 Months 100 Marvin E Reid, MB BS PhD, Marvin Reid, Naydenne Williams, MBBS DM, Tomlin Paul 2020-12-04
TeenCove: A Study to Evaluate the Safety, Reactogenicity and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to < 18 Years Old to Prevent COVID-19 Coronavirus disease 19 infection mRNA-1273 alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Children (6-12 yrs), Adolescents (13-17 yrs) ModeRNA Therapeutics Biomedical Advanced Research and Development Authority (BARDA) US 2020-11-30 2022-06-30 MRNA-1273-P203, NCT04649151, TeenCove Phase 2/Phase 3 Clinical Recruiting 7 19 Months 3000 Moderna Clinical Trials 2020-12-14
Profiling Recovery of Those Discharged Into the Community With COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Derby Sheffield Hallam University, University Hospitals Of Derby and Burton NHS Foundation Trust UK 2021-01-04 2021-12-17 COVID-19-UOD&RDH20/21, NCT04649957 Phase Not Applicable Not yet recruiting 1 11 Months 100 Amanda Baxendale, PhD, Mark A Faghy, PhD, Ruth Ashton, PhD, Tom Bewick, MD, Tom Maden-Wilkinson, PHD 2020-12-07
Well-being in Cancer Patients With Neuropathy During COVID-19 Who Participated in Prior Clinical Trials Coronavirus disease 19 infection, Neuropathic pain MD Anderson Cancer Center National Cancer Institute US 2020-05-26 2021-07-01 2020-0508, 2020-0508, NCI-2020-06014, NCT04650178 Phase Not Applicable Recruiting 1 13 Months 274 Sarah Prinsloo 2020-12-04
Differences in Exhaled Breath by Using Ion Mobility Spectrometry (IMS) in Subjects Tested for SARS-CoV-2 Infection (COVID-19 Disease) Coronavirus disease 19 infection Ion Mobility Spectrometry (IMS) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) B Braun Melsungen AG CeGaT Germany 2020-12-14 2021-05-31 HC-N-H-2006, NCT04649931 Phase Not Applicable Recruiting 1 5 Months 400 Juergen Schaefer, Prof. Dr., Study Manager 2020-12-19
Perception of the COVID-19 Pandemic in Patients With Hematological or Solid Neoplasias Acute stress disorder, Coronavirus disease 19 infection, Hematological neoplasm, Solid tumor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medizinische Universität Innsbruck Austria 2020-11-23 2020-12-31 1264/2020, NCT04649320 Phase Not Applicable Recruiting 1 1 Month 300 Reinhard Stauder, M.D. 2020-12-04
COVID-19 Nasal Swab Trial Coronavirus disease 19 infection CanSwab alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Orthopaedic Innovation Center Inc Canada 2020-12-31 2021-02-28 B2020:121, NCT04649424 Phase Not Applicable Not yet recruiting 1 2 Months 72 Anand Kumar, MD, Gloria Vasquez-Grande, MD, Kerry Dust, MD, Paul Van Caeseele, MD, Sarah Tran, Trevor Gascoyne 2020-12-04
ResCOVID: A Clinical Trial for Hospitalized Patients With COVID-19 in Ceara Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Escola de Saúde Pública do Ceará Brazil 2020-04-02 2021-12-30 3.948.100, NCT04649827, ResCOVID Phase Not Applicable Recruiting 1 20 Months 3000 Jadson A' Franco, Marcelo A Holanda, PHD 2020-12-04
Convalescent Plasma for Treatment of COVID-19: An Open, Randomized, Controlled Trial Coronavirus disease 19 infection SARS-CoV-2 convalescent plasma alone, steroid therapy alone, SARS-CoV-2 convalescent plasma plus betamethasone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Karolinska University Hospital Danderyd Hospital, Falu Hospital, Karolinska Institutet Sweden 2020-12-03 2022-02-01 CP3, NCT04649879 Phase 2/Phase 3 Clinical Not yet recruiting 3 13 Months 920 Alexandre Bonnard, MD, Anne Börjesson Hanson, Hanna Sahlgren, MD, Joakim Dillner, Joakim Dillner, MD, PhD, Johan Rudling, MD, Johan Ursing, MD, PhD, Karin Norlin, Karl Hagman, MD, Lena Flod, Magnus Hedenstierna, MD, PhD, Maria Eriksdotter, Miia Kivipelto, Ulf Öhlund 2020-12-07
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis Coronavirus disease 19 infection, Deep vein thrombosis, Ischemic stroke, Lung embolism, Myocardial infarction, Thromboembolism apixaban alone Factor Xa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Duke University National Heart Lung and Blood Institute US 2020-12-31 2021-09-30 NCT04650087, PRO00107078 Phase 3 Clinical Not yet recruiting 1 9 Months 5320 Thomas L. Ortel, MD, PhD, Thomas Ortel, M.D., Ph.D, Tracy Wang, MD 2020-12-04
Effect of Favipiravir on outpatient treatment of COVID-19 Coronavirus disease 19 infection favipiravir alone RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Isfahan University of medical Sciences Iran 2020-12-21 IR.MUI.MED.REC.1399.780, IRCT20171219037964N3 Phase 3 Clinical Not yet recruiting 3 70 Babak Amra, Dr. Babak Amra, Dr. Forough Soltaninejad, Dr. Mehrdad Salahi, Shaghayegh haghjooy Javanmard 2020-12-04
A trial to evaluate INNA-051 for the potential treatment of Covid-19 patients Coronavirus disease 19 infection INNA-051 alone TLR-2 agonist, TLR-6 agonist Ena Respiratory Medical Research Commercialization Fund Phase Not Applicable Planned 0 2020-12-15
Variation in Acute Appendicitis During COVID-19 Pandemic in Italy Appendicitis, Coronavirus disease 19 infection appendectomy alone University of Milano-Bicocca Italy 2020-09-01 2020-11-30 APPENDICITE-COVID, Appendicitis-pandemic, NCT04649996 Phase Not Applicable Completed 6 3 Months 532 2020-12-07
A multiple-ascending dose study to evaluate RP-7214 in Covid-19 patients Coronavirus disease 19 infection RP-7214 alone Dihydroorotate dehydrogenase inhibitor Rhizen Pharmaceuticals SA US Phase Not Applicable Planned 1 2020-12-03
ABDALA: ABDALA Clinical Study Coronavirus disease 19 infection CIGB-66 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Genetic Engineering and Biotechnology Cuba 2020-07-12 2021-05-31 ABDALA, IG / CIGB-66I / CVD19 / 2002, RPCEC00000346 Phase 1/Phase 2 Clinical Not yet recruiting 1 10 Months 132 Francisco Hernandez Bernal, Maria Carmen Ricardo Cobas 2020-12-11
Efficacy and Safety of TY-027, a Treatment for COVID-19, in Humans Coronavirus disease 19 infection TY-027, Tychan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tychan Pte Ltd Singapore, Israel 2020-12-04 2021-12-30 NCT04649515, SCT-301 Phase 3 Clinical Recruiting 5 12 Months 1305 Anjali Baglody, MSc, Jenny Low, MBBS, Justin Ng, PhD 2020-12-15
A first-in-man, single ascending dose study to evaluate RP-7214 in healthy subjects Coronavirus disease 19 infection RP-7214 alone Dihydroorotate dehydrogenase inhibitor Healthy volunteers accepted Rhizen Pharmaceuticals SA US Phase 1 Clinical Not yet recruiting 1 2020-12-03
Curmeric-Prevention-COVID-19-Health Personnel-General Calixto Garcia University Hospital Coronavirus disease 19 infection curmeric alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Center for Technological Applications and Nuclear Development (CEADEN) Calixto Garcia Hospital, Ministerio de Salud Publica Cuba 2020-03-19 2020-04-18 RPCEC00000344 Phase Not Applicable No longer recruiting 1 1 Month 199 Tania Valdes González, Yanet Morejon Diaz 2020-12-07
COVID-19 and Sports - an Online Survey on the Impact of the Pandemic and Possible Preventive Measures Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medizinische Universität Innsbruck Universitat Innsbruck Austria 2020-06-15 2020-08-31 20200609, NCT04649333 Phase Not Applicable Completed 1 2 Months 1336 2020-12-08
STEPCO: Short and Medium-term Effects of Pulmonary Rehabilitation in Mild to Critical Post-acute COVID-19 Coronavirus disease 19 infection pulmonary rehabilitation program alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Schön Klinik Berchtesgadener Land Germany 2020-11-25 2021-03-31 COVID-REHAB, NCT04649918, STEPCO Phase Not Applicable Recruiting 1 4 Months 50 Andreas R Koczulla, MD, Rainer Gloeckl, PhD 2020-12-07
Surfactant Protein Genetic Variants in COVID-19 Infection Coronavirus disease 19 infection genetic test alone Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Milton S. Hershey Medical Center US 2020-03-01 2021-12-31 15456, NCT04650191 Phase Not Applicable Recruiting 1 22 Months 300 Chintan Gandhi, Chintan K Gandhi, MD, MBBS 2020-12-04
A retrospective study to evaluate the epidemiological and clinical characteristics of older patients with COVID-19 outside Wuhan Coronavirus disease 19 infection epidemiological and clinical analysis alone National Natural Science Foundation of China China Phase Not Applicable Status not specified 1 788 2020-12-03
Sharing Stories: a digital intervention for caregivers with young children in the COVID-19 era to promote child social, emotional and language development, responsive parenting and parental mental wellbeing in Zambia, Tanzania and Uganda Coronavirus disease 19 infection, Psychiatric disorder Sharing Stories digital group-based parenting intervention alone University of Stellenbosch The LEGO Foundation Tanzania, Zambia, Uganda 2020-06-01 2021-05-31 ISRCTN77689525 Phase Not Applicable No longer recruiting 4 12 Months 720 Prof Sarah Skeen 2020-12-04
A retrospective study to evaluate the therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia Coronavirus disease 19 infection, Pneumonia adenosine alone Universita degli Studi di Roma La Sapienza Phase Not Applicable Status not specified 0 66 2020-12-03
Types of drugs used and their side effects in COVID-19 patients Coronavirus disease 19 infection Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Maulana Azad Medical College India 2020-12-07 CTRI/2020/12/029463 Phase Not Applicable Not yet recruiting 1 1000 Dr Bhupinder Singh, Dr Bhupinder Singh Kalra 2020-12-04
How COVID-19 affected MAHE students diet and lifestyle practices Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs) Welcomgroup Graduate School of Hotel Administration India 2020-12-03 CTRI/2020/12/029456 Phase Not Applicable Not yet recruiting 1 294 Asha Moideen, Aswindev, Aswindev J, Dr Meenakshi Garg 2020-12-04
Study of COVID-19 infection in hemodialysis and post-renal transplant patients Coronavirus disease 19 infection, End stage renal disease, Kidney dialysis, Kidney transplantation Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shree Krishna Hospital, The Healing Tree India 2020-12-11 CTRI/2020/12/029478 Phase Not Applicable Not yet recruiting 1 80 Dr Maulin Shah 2020-12-04
HBOTpCOVID: Hyperbaric Oxygen Therapy for Post-COVID-19 Syndrome Cognitive disorder, Coronavirus disease 19 infection hyperbaric oxygen therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assaf-Harofeh Medical Center Israel 2021-01-01 2023-01-01 332-20-ASF, HBOTpCOVID, NCT04647656 Phase Not Applicable Not yet recruiting 1 24 Months 70 Shai Efrati, Prof., Shani Zilberman-Itskovich, Dr. 2020-12-04
MAMBISA study: Adaptive phase I/II clinical trial, randomized, of parallel-groups, to evaluate the safety and immunogenicity in adults of two vaccine candidates, based on recombinant RBD subunits for the prevention of COVID-19 in regimens that use the nasal route of administration. (COVID-19) Coronavirus disease 19 infection CIGB-66 alone, CIGB-669 alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Center for Genetic Engineering and Biotechnology Cuba 2020-12-07 2021-05-31 IG / VPIN / CVD19 / 2001, MAMBISA study, RPCEC00000345 Phase 1/Phase 2 Clinical Not yet recruiting 1 5 Months 88 Carlos Alberto Gonzalez Delgado, Zurina Cinza estevez 2020-12-11
Clinical Characteristics and Outcomes of Patients with COVID-19 Admitted in the ICU of a Tertiary Public Hospital and COVID-19 Referral Center in the Philippines Coronavirus disease 19 infection Philippine General Hospital Philippines 2020-04-01 2020-06-01 PHRR201125-003177 Phase Not Applicable No longer recruiting 1 2 Months Aprille Anne O. Octaviano, Blessie Marie B. Perez, Jubert P. Benedicto, MD 2020-12-03
MAC VITAL: Implementing Peri-operative Mobile Application for Contactless Vital Signs Coronavirus disease 19 infection Anura Research app alone, standard vital sign measurement device alone, vital sign measurement alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University Health Network Canada 2020-12-15 2024-12-15 MAC VITAL, NCT04648111, PROTOCOL VERSION: OCT 29, 2020 Phase Not Applicable Not yet recruiting 1 48 Months 200 2020-12-02
Effect of medical mask on maternal oxygen saturation and fetal non-stress test during late third trimester of pregnancy in the COVID-19 era Coronavirus disease 19 infection surgical mask alone Healthy volunteers accepted, Female, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Native American Ancestry Srinakarinwirot University Thailand 2020-12-01 TCTR20201124002 Phase 0 Clinical Not yet recruiting 1 70 Tharangrut Hanprasertpong 2020-12-08
Exploratory Study: COVID-19 and Pregnancy Coronavirus disease 19 infection SARS-CoV-2 serology test alone Healthy volunteers accepted, Female, Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Brazil 2020-09-21 2022-06-13 30270820.3.0000.0068, NCT04647994 Phase Not Applicable Recruiting 1 20 Months 500 Ana CS Farche, PhD, Ana Claudia S Farche, PhD, Rossana P Francisco, PhD 2020-12-03
Re_Co: Medical Rehabilitation after Coronavirus Disease (Covid-19)/ Re_Co Acute stress disorder, Coronavirus disease 19 infection pneumological rehabilitation alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University of Lubeck Deutsche Rentenversicherung Bund Germany 2021-02-01 20-391, DRKS00023642, Re_Co Phase Not Applicable Not yet recruiting 2 580 Ruth Deck 2020-12-03
COVER-Studie: Investigation of factors that may influence the course of a SARS-CoV-2 infection (COVID-19): A study of the University Medical Center Greifswald Coronavirus disease 19 infection questionnaire alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Medicine Greifswald Germany 2020-04-30 BB 059/20, COVER-Studie, DRKS00021672 Phase Not Applicable Recruiting 1 400 Eik Schäfer, Klaus Hahnenkamp, Wolfgang Hoffmann 2020-12-03
A cohort study to evaluate the clinical and laboratory features and short-term outcomes of patients with coronavirus disease 2019 (COVID-19) Coronavirus disease 19 infection antimicrobial alone, clinical and laboratory features analysis alone, glucocorticoid alone Chinese Academy of Medical Sciences China Phase Not Applicable Status not specified 1 102 2020-12-02
IFN-beta-1b and Remdesivir for COVID19 Coronavirus disease 19 infection interferon beta-1b plus remdesivir COVID19 non structural protein 8 modulator, COVID19 replicase polyprotein 1ab inhibitor, RNA polymerase modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) The University of Hong Kong Hong Kong 2020-11-20 2021-09-30 NCT04647695, UW 20-535 Phase 2 Clinical Recruiting 1 10 Months 100 Ivan FN Hung, MD FRCP, Kelvin KW To, MD FRCPath 2020-12-14
ASAP-C: Corticosteroids in Severe COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Brno Czech Republic 2021-01-01 2021-04-01 ASAP-C, ASAP-C STUDY, NCT04648410 Phase Not Applicable Not yet recruiting 1 3 Months 2000 Jan Malaska, MD. Ph.D., Jan Malaska, MD., Ph.D, Jozef Klučka, assoc.Prof.MD, Ph.D, Jozef Klučka, assoc.prof.MD.Ph.D., Petr Štourač 2020-12-03
A retrospective study to evaluate the negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients Coronavirus disease 19 infection, Hyperglycemia tocilizumab alone University of Campania Luigi Vanvitelli Italy Phase Not Applicable Status not specified 1 475 2020-12-02
Starling Registry Study Coronavirus disease 19 infection Starling detector system alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Baxter Healthcare Corp US 2020-12-07 2022-07-31 BXU553561, NCT04648293 Phase Not Applicable Not yet recruiting 1 19 Months 600 Baxter Clinical Trials Disclosure Call Center, Jennifer Sahatjian 2020-12-02
Covid outcomes among patients with comorbidities Asthma, Cancer, Cardiovascular disease, Cerebrovascular trauma, Chronic obstructive pulmonary disease, Connective tissue disease, Coronavirus disease 19 infection, Diabetes mellitus, Endocrine disease, HIV infection, Hematological disease, Hypertension, Immune deficiency, Interstitial lung disease, Mycobacterium tuberculosis infection, Obesity, Psychiatric disorder, Renal disease, Rheumatoid arthritis, Systemic lupus erythematosus, Vasculitis Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sri Ramachandra University India 2020-12-15 CTRI/2020/12/029452 Phase Not Applicable Not yet recruiting 1 1000 Dr Swathy Moorthy, DrSPThiagarajan 2020-12-03
A phase IV clinical study to assess Carragelose in healthcare professionals, who are managing COVID-19 patients Coronavirus disease 19 infection iorta-carrageenan (intranasal, COVID-19), Marinomed Biotechnology alone Marinomed Biotechnologie GmbH Austria Phase 4 Clinical Planned 1 334 Dr. Christoph Wenisch 2020-12-02
CLARITY: Controlled evaLuation of Angiotensin Receptor Blockers (DMX-200) for COVID-19 respiratory disease Coronavirus disease 19 infection irbesartan + propagermanium (oral extended release, chronic kidney disease/diabetic retinopathy/NASH/focal segmental glomerulosclerosis/diabetic nephropathy), Dimerix Bioscience alone Angiotensin II AT-1 receptor antagonist, CCR2 chemokine antagonist Dimerix Bioscience Pty Ltd CLARITY Phase Not Applicable Status not specified 0 2020-12-08
CLARITY 2.0: A prospective, multicenter, randomized, double-blind, placebo-controlled study to evaluate the assess the safety and effectiveness of DMX-200 in COVID-19 patients Coronavirus disease 19 infection irbesartan + propagermanium (oral extended release, chronic kidney disease/diabetic retinopathy/NASH/focal segmental glomerulosclerosis/diabetic nephropathy), Dimerix Bioscience alone Angiotensin II AT-1 receptor antagonist, CCR2 chemokine antagonist Dimerix Bioscience Pty Ltd Australia CLARITY 2.0 Phase 3 Clinical Recruiting 1 600 Meg Jardine 2020-12-08
A clinical study to determine the effect of CL-20189 and CL-20193 in mild to moderate COVID-19 patients Coronavirus disease 19 infection CL-20189 alone, CL-20193 alone, standard therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) CLS Pvt Ltd India 2020-12-07 CLS/CV/CL20189/20 Version 1.0, CTRI/2020/12/029475 Phase 2 Clinical Not yet recruiting 1 66 Dr K Sunil Naik, Mr Ajjarapu Srinivasu, Mr Kavangula Krishna Chaitanya 2020-12-03
A clinical trial to study the effect of herbal medicine on enhancing immune function in COVID recovery patients Coronavirus disease 19 infection aswagandha + amla + shilajeet extract alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Natreon Inc, Kolkata India 2020-12-15 CTRI/2020/12/029476, JBR/RU/CT-16/20 version 1.3 Phase 2 Clinical Not yet recruiting 1 120 Dr Srikanta Pandit 2020-12-04
COVIMMUNITY: Evaluation and Longitudinal Follow-up of Biomarkers Predictive of Severe Forms of COVID-19 Coronavirus disease 19 infection ELISPOT assay alone, QuantiFERON assay alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Centre Hospitalier Universitaire de Saint Etienne France 2020-12-01 2022-12-01 20CH207, COVIMMUNITY, NCT04648709 Phase Not Applicable Not yet recruiting 1 24 Months 100 Anne-Emmanuelle BERGER, MD, Florence Rancon, Stéphane PAUL, Stéphane Paul, PHD 2020-12-04
COVPROSHIELD: Effectiveness and Adherence to Closed Face Shields to Prevent COVID-19 Transmission Coronavirus disease 19 infection Closed face shield alone, Surgical face mask alone, educational video alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidad Los Andes Roche Pharma AG, United Nations Colombia 2020-12-31 2021-03-31 1010166518, COVPROSHIELD, NCT04647305 Phase Not Applicable Not yet recruiting 1 3 Months 233 Alejandro Pacheco Gurruchaga, MSc, Andrea Ramirez Varela, PhD, Eduardo Behrentz, PhD, Giancarlo Buitrago Gutierrez, PhD, Jhon M. Gonzalez, PhD, José D. Pinzón, MSc, Juan D. Martin, MSc, Juan J. Yepes Nuñez, PhD, Luis J. Hernandez Florez, PhD, Rachid Laajaj, PhD, Silvia Restrepo Restrepo, PhD 2020-12-02
CRISOL Contigo: Multi-level Intervention to Reduce the Disproportionate Toll of COVID-19 Among Latino Communities in Philadelphia Coronavirus disease 19 infection, Psychiatric disorder Community popular opinion leader (POL) based intervention alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Drexel University US 2021-01-06 2021-10-31 3R21MD012352-02S1, CRISOL Contigo, NCT04646616 Phase Not Applicable Not yet recruiting 1 9 Months 800 Amy Carroll-Scott, PhD, Ana Martinez Donate, Ana Martinez-Donate, PhD, Mariana Lazo, PhD, Seth L. Welles, PhD 2020-12-09
NOS: Nutritional Status in Locally Advanced or Metastatic Solid Cancer Patients in Spain: the NutriOncoSearch (NOS) Study Advanced solid tumor, Coronavirus disease 19 infection, Malnutrition chemotherapy alone, immunotherapy alone, radiotherapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Universidad Pontificia Comillas De Madrid Baxter Healthcare Corp, European Society for Medical Oncology, IQVIA RDS Pty Ltd Spain 2020-06-10 2020-12-15 NCT04168814, NOS, SEEO-19-01-NOS Phase Not Applicable No longer recruiting 11 6 Months 586 Julio C de la Torre-Montero, Ph.D 2020-12-03
Responsible Gambling Telephone Intervention to High-risk Gamblers by a State-owned Gambling Operator in Sweden Coronavirus disease 19 infection Motivational telephone intervention alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lunds University Bioscience Svenska Spel Sweden 2020-11-30 2021-11-30 NCT04646421, OMSORGSSAMTAL Phase Not Applicable Recruiting 1 12 Months 3626 Anders Håkansson, PhD 2020-12-03
A phase II clinical study to assess COH-04S1 in the treatment of patients with SARS-CoV-2 Coronavirus disease 19 infection COH-04S1 alone City of Hope 2021-06-30 Phase 2 Clinical Planned 0 2020-12-16
The effect of hemoperfusion on patients with severe symptoms of covid-19 which are resistant to conventional therapies Coronavirus disease 19 infection, Respiratory distress syndrome hemoperfusion alone Oroumia University of Medical Sciences Iran 2020-11-10 IR.UMSU.REC.1399.259, IRCT20180625040232N7 Phase Not Applicable Recruiting 1 20 Saman Farshid, ِDr Iraj Mohebi 2020-12-02
Effects of herbal drug Imfluna on patients with COVID-19 Coronavirus disease 19 infection, Viral pneumonia Imfluna, Zarsan Salamat Pharmaceutical Company alone, standard medications alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Zarsan Salamat Company Iran 2020-11-15 IR.MEDSAB.REC.1399.115, IRCT20080901001157N17 Phase 2 Clinical Recruiting 1 60 Afsaneh Kafash, Fallah Huseini Hasan, Fereshtah Qorat, Mehdi Khairabadi, Mohammadreza Gholibeikian 2020-12-02
Epidemiology and clinical features in patients with COVID-19 in Mexican Southeast: A retrospective analysis Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hospital Regional de Alta Especialidad Juan Graham Tabasco Mexico 2020-03-30 2020-12-31 ACTRN12620001265965, ANZCTR380303 Phase Not Applicable No longer recruiting 1 9 Months 1000 Guadalupe del Carmen Baeza Flores, Jesús Arturo Ruiz Quinones 2020-12-02
Evaluation of SARS-CoV-2 Serum Antibody Titer in Pediatric Health Workers Coronavirus disease 19 infection St Marianna University School of Medicine Japan 2020-12-01 UMIN000042599 Phase Not Applicable Not yet recruiting 1 30 Yukitsugu Nakamura 2020-12-02
A phase IV study of iorta-carrageenan (intranasal, COVID-19), Marinomed Biotechnology for the prevention of SARS-CoV-2 infection Coronavirus disease 19 infection iorta-carrageenan (intranasal, COVID-19), Marinomed Biotechnology alone Marinomed Biotechnologie GmbH Phase 4 Clinical Planned 0 2020-12-02
A Phase III Clinical Trial to Determine the Safety and Efficacy of ZF-2001 for Prevention of COVID-19 Coronavirus disease 19 infection ZF-2001 alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over), Asian Ancestry Anhui Zhifei Longcom Biopharmaceutical Co Ltd China 2020-12-16 2022-04-30 LKM-2020-NCV-GJ01, NCT04646590 Phase 3 Clinical Recruiting 1 16 Months 29000 Fan Di, Master, Fangjun Li, Bachelor 2020-12-19
MRG-001 as an Immunoregulatory and Regenerative Therapy for COVID-19 Patients Coronavirus disease 19 infection MRG-001, Medregen alone Young Adults (18-44 yrs) Medregen Llc Kendall Healthcare Group, Ltd US 2021-01-05 2021-06-05 MRG2020, NCT04646603 Phase 1/Phase 2 Clinical Not yet recruiting 1 5 Months 12 Ali R Ahmadi, PhD, James F Burdick, MD, Michael E Nottidge, MD 2020-12-08
Psychological Health, Coping Strategies and Preferences of Military COVID-19 Deployers Acute stress disorder, Coronavirus disease 19 infection Healthy volunteers accepted David Grant USAF Medical Center US 2020-12-31 2021-05-31 FWH20200203E, NCT04646642 Phase Not Applicable Not yet recruiting 1 5 Months 160 Amanda Fox 2020-12-02
The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs Coronavirus disease 19 infection Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs) Selcuk University Turkey 2020-10-01 2021-02-01 2020/480, NCT04646525 Phase Not Applicable Recruiting 1 4 Months 300 Merih Onal, Assist. Prof., Merih Onal, M.D., Selcen Celik 2020-12-02
ARC: Establish and analyse a model of care for the management of people taking oral anti-cancer medications by an Advanced Nurse Practitioner: a pilot study Cancer, Coronavirus disease 19 infection anti-cancer medication alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Irish Cancer Society Ireland 2020-04-08 2022-09-14 ARC, CNRA19RICH, ISRCTN10401455 Phase Not Applicable Recruiting 2 29 Months 40 Dr Janice Richmond, Prof Andrew Murphy 2020-12-02
EMOS-COVID: Enoxaparin at Prophylactic or Therapeutic Doses in COVID-19 Coronavirus disease 19 infection, Respiratory failure, Thrombosis, Viral pneumonia enoxaparin sodium alone Low molecular weight heparin Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) ASST Fatebenefratelli Sacco Universita degli Studi di Milano, Universita' Degli Studi Di Foggia, University of Milano-Bicocca Italy 2020-07-27 2021-07-31 EMOS-COVID, HLS-02COVID19/2020, NCT04646655 Phase 3 Clinical Recruiting 1 12 Months 300 Maddalena A Wu, M.D., Massimo Arquati, M.D. 2020-12-02
Effect of internet-delivered psychoeducation program named 'Imacoco-care' on improving psychological distress among workers under COVID-19 infection Acute stress disorder, Coronavirus disease 19 infection, Panic disorder Imacoco-care alone, internet-delivered psychoeducational program alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Tokyo Japan 2020-12-05 UMIN000042556 Phase Not Applicable Not yet recruiting 1 1000 Kotaro Imamura, Norito Kawakami 2020-12-02
Covid-19 Risk Factors and Pattern Between Healthcare Workers Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Assiut University Egypt 2020-12-31 2022-01-31 COVID-19 PATTERRN, NCT04646551 Phase Not Applicable Not yet recruiting 1 13 Months 165 Duaa Bahgat Abdelhamed, Mohamed Mostafa Abdelhady, Sahar Ahmed, Sahar Ahmed Okily 2020-12-02
Remote Patient Monitoring (RPM) for patients with COVID-19 and other infection Coronavirus disease 19 infection, Infectious disease Medopad alone, Remote patient monitoring solutions alone, SaniQ Infekt alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Zentralinstitut für die kassenärztliche Versorgung in der Bundesrepublik Deutschland Germany 2020-12-01 DRKS00023553, Eth-KB 19/20 Phase Not Applicable Not yet recruiting 6 120 Sarah Eichler 2020-12-03
STOP CC: Effects of a low-threshold Substitution Therape of Opioid-dependent Patients during the Corona Crisis (COVID-19) Coronavirus disease 19 infection, Opiate dependence substitution therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Drob Inn University of Hamburg Germany 2020-10-14 2020-10058-BO, DRKS00023401, STOP CC Phase Not Applicable Recruiting 1 80 Fabian Vorberg, Uwe Verthein 2020-12-03
CoV-Surv: Effectiveness and cost-effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population: study protocol for a cluster-randomized, two-factorial, controlled trial Coronavirus disease 19 infection Reverse Transcription Loop-mediated Isothermal Amplification (RT-LAMP) alone, pre-screening questionnaire alone, saliva sample alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Heidelberg Bundesministerium für Bildung und Forschung, Gesundheitsamt Rhein-Neckar Germany 2020-11-18 CoV-Surv, DRKS00023271, S-790/2020, U1111-1259-3834 Phase Not Applicable Recruiting 1 10000 Andreas Deckert 2020-12-02
CarECorona: Nursing care in times of corona (Covid-19). Scientific study on challenges and pressures from the perspective of leaders (continued) Is the threat of system collapse still present or are we normalizing the madness? Coronavirus disease 19 infection Lime-Survey alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Cologne Germany 2020-12-03 20-1459, CarECorona, DRKS00023402 Phase Not Applicable Recruiting 1 1000 Kira Hower 2020-12-02
A clinical trial to study effect of Madhav Rasayan tablets in COVID-19 patients Coronavirus disease 19 infection Madhav Rasayan alone, Standard treatment alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Shri Vishwavati Ayurved Chikitsalaya and Research Centre India 2020-12-03 CTRI/2020/11/029444, SVACRC/20/1 V 2.0 Phase 3 Clinical Not yet recruiting 0 60 Dr Pankaj H Bansode, Dr Tushar Saundankar, Shailesh Balkrishna Malekar 2020-12-10
Effect of remote management on comprehensive management of diabetes mellitus during the COVID-19 epidemic Coronavirus disease 19 infection, Diabetes mellitus WeChat APP alone, remote management alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Second Hospital of Jilin University China 2020-12-01 2021-05-01 ChiCTR2000040366 Phase Not Applicable Recruiting 1 5 Months 90 Chuan Zhang, Jing Kang 2020-12-02
Special project to support elderly singleton or doubleton in the new wave of COVID-19 pandemic Coronavirus disease 19 infection Telecare alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) China 2020-12-01 2022-11-30 ChiCTR2000040324 Phase 0 Clinical Recruiting 1 24 Months 11000 Daisy Dexing Zhang, Samuel YS Wong 2020-12-04
Reinfection with SARS-COV-2 and associated factors Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Christian Medical College, Vellore, India Bill & Melinda Gates Foundation India 2021-01-04 CTRI/2020/11/029438 Phase Not Applicable Not yet recruiting 0 600 Jacob John 2020-12-10
A phase I clinical trial to evaluate the safety and immunogenicity of BNT-162b2 in healthy Chinese subjects Coronavirus disease 19 infection BNT-162b2 alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Asian Ancestry BioNTech SE, Shanghai Fosun Pharmaceutical (Group) Co Ltd China 2020-08-01 Phase 1 Clinical Recruiting 1 2020-12-01
Effect of Favipiravir on Mortality in Patients With COVID-19 at a Tertiary Center Intensive Care Unit Coronavirus disease 19 infection favipiravir alone, lopinavir + ritonavir alone HIV protease inhibitor, RNA polymerase inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Hamidiye Etfal Training and Research Hospital Turkey 2020-03-15 2020-05-15 2854, NCT04645433 Phase Not Applicable Completed 1 2 Months 100 sultan acar sevinc 2020-12-02
A phase I/II, randomized, double-blind, placebo-controlled, two-stage, multicenter study of HFB-30132A in the treatment of patients with COVID-19 infection Coronavirus disease 19 infection HFB-30132A alone Angiotensin converting enzyme 2 inhibitor, COVID19 Spike glycoprotein inhibitor HiFiBio PJSC Pharmsynthez, Shemyakin Institute of Bioorganic Chemistry Russian Federation Phase 1/Phase 2 Clinical Planned 1 2020-11-30
The effect of wearing face masks on cognitive functioning Cognitive disorder, Coronavirus disease 19 infection PPE mask (Safe Plus) alone Healthy volunteers accepted, Young Adults (18-44 yrs) University of Otago New Zealand 2020-07-29 2020-10-27 ACTRN12620001215910, ANZCTR380747 Phase Not Applicable Completed 1 2 Months 50 Liana Machado, Neda Nasrollahi 2020-12-02
Investigating the safety, satisfaction and efficacy of pulmonary tele rehabilitation for people with respiratory conditions, including patients recovering from COVID-19 Asthma, Bronchiectasis, Chronic obstructive pulmonary disease, Coronavirus disease 19 infection, Interstitial lung disease, Lung tumor Aerobic training alone, Strength training alone, Warm up stretches alone, education sessions alone, pulmonary telerehab exercise training alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Royal Prince Alfred Hospital Australia 2021-02-01 ACTRN12620001279910p, ANZCTR380787, U1111-1259-9240 Phase Not Applicable Not yet recruiting 1 100 Lissa Spencer 2020-12-01
Effects of Fuzheng Huayu Tablets on COVID-19 Coronavirus disease 19 infection Fuzheng Huayu capsule alone, conventional therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) ShuGuang Hospital, China Hubei province hospital of Traditional Chinese Medicine, Jingmen No.1 People’s Hospital China 2020-02-01 2020-04-15 FZHY-NCP-1, NCT04645407 Phase 4 Clinical Completed 1 2 Months 66 Liu Chenghai 2020-12-02
Using Whatsapp for the Consultation Coronavirus disease 19 infection Infectious disease specialist-led video consultation alone, whastapp application alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kafkas University Turkey 2020-03-11 2020-05-31 CLINICAL-3, NCT04645563 Phase Not Applicable Completed 1 2 Months 144 Ramazan Sbirli 2020-12-02
A novel PhIV precision medicine interventional clinical trial to assess potential link between COVID-19 and hypertension Coronavirus disease 19 infection, Hypertension drug therapy alone, smart phone app alone Closed Loop Medicine Ltd Queen Mary University of London, Technology Strategy Board, William Harvey Clinical Research Centre 2020-11-18 Phase Not Applicable Recruiting 0 1000 2020-11-30
Impact of COVID-19 pandemic on hepatobiliary and pancreatic surgical services Coronavirus disease 19 infection, Surgical procedure Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Tan Tock Seng Hospital Singapore 2019-01-01 2020-06-30 ChiCTR2000040265 Phase Not Applicable Completed 1 18 Months 547 Teo Zhe Hao Timothy 2020-12-02
A study to evaluate post COVID-19 lung damage Coronavirus disease 19 infection, Lung injury, Viral pneumonia Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Medanta The Medicity India 2020-12-15 COVIP/2020/001 Version 01, CTRI/2020/11/029437 Phase Not Applicable Not yet recruiting 1 300 Dr Bornali Datta 2020-12-03
A Placebo-Controlled Trial of Bempegaldesleukin (BEMPEG; NKTR-214) With Standard of Care in Patients With Mild COVID-19 Coronavirus disease 19 infection bempegaldesleukin alone, standard of care alone CD122 agonist, IL-2 receptor agonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Nektar Therapeutics US 2020-11-13 2021-03-27 20-214-34, NCT04646044 Phase 1b Clinical Recruiting 2 4 Months 30 Nektar, Praveena Raman, Study Director 2020-12-01
Covid with AKI Coronavirus disease 19 infection, Renal injury Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sardar Vallabhbhai Patel Institute of Medical Science and Research India 2020-12-14 CTRI/2020/11/029414 Phase Not Applicable Not yet recruiting 1 100 DR ISHAN A DESAI, DR NEHAL M SHAH 2020-12-01
PEPCO: A Phase III, post exposure prophylaxis for COVID-19 study to evaluate avigan tablets (favipiravir) in the prevention of COVID-19 Coronavirus disease 19 infection Avigan alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Appili Therapeutics Inc Cato Research LLC US, Canada PEPCO Phase 3 Clinical Not yet recruiting 2 1156 2020-12-04
An observational study to evaluate the effect of hydroxychloroquine and azithromycin on arrhythmic profile and QT interval in patients with COVID-19 Coronavirus disease 19 infection azithromycin plus hydroxychloroquine Healthy volunteers accepted University of Padova Phase Not Applicable Status not specified 0 22 2020-11-30
Efficacy of Date Palm Leaf Extract (Phoenix dactylifera) in Patients with COVID-19 Hospitalized in Ganjavian Hospital in Dezful Coronavirus disease 19 infection palm leaf extract (Phoenix dactylifera) alone Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dezful University of Medical Sciences Iran 2020-09-12 2020-11-16 IR.DUMS.REC.1399.037, IRCT20201015049036N1 Phase 2 Clinical Completed 1 2 Months 100 Dr. Maysam Mard Soltani, Mohammad Dorchin 2020-12-01
Expanded-Access to T-89 for Treatment Use in Intermediate-size Patients Population With COVID-19 Coronavirus disease 19 infection T-89 alone Tasly Pharmaceuticals Inc Tasly Pharmaceutical Group Co Ltd US NCT04646031, T89-ROUSA-01 Phase Not Applicable Recruiting 1 Anni Li, Danielle Wahinekapu, Henry H Sun, PhD, MD, Libby Bliss, Patrick Meehan, PhD, MD 2020-12-01
Biomarkers of Trained Immunity Following MMR Vaccination Coronavirus disease 19 infection MMR vaccine alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Washington University School of Medicine, US 2020-12-31 2021-04-30 202011081, NCT04646239 Phase Not Applicable Not yet recruiting 1 4 Months 80 Jonathan Jocum, MD, Leon du Toit, MD, Linda Yun, Michael S Avidan, MD, Shabaana Khader, PhD, Shail Mehta, MD 2020-12-06
Ivermectin for Severe COVID-19 Management Coronavirus disease 19 infection, Viral pneumonia Variable regimens including azithromycin , favipiravir , hydroxychloroquine , ivermectin (solution/enteral, COVID-19), NeuTec Pharma/Afyonkarahisar Health Sciences University RNA polymerase inhibitor Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Afyon karahisar University of Health Sciences NeuTec Pharma plc Turkey 2020-05-11 2020-09-02 IVMC_03, NCT04646109 Phase 3 Clinical Completed 4 3 Months 60 Neşe Demirtürk, A. Prof. Dr., Nurullah Okumuş, Nurullah Okumuş, Prof. Dr., Rahmet Güner, Prof. Dr., Rıza A. Çetinkaya, Prof. Dr., İsmail Y. Avcı 2020-12-09
COVID19-MHM: COVID-19 and Hereditary Metabolic Diseases Coronavirus disease 19 infection, Gaucher disease, Urea cycle disorder Centre Hospitalier Regional Universitaire de Lille France 2021-01-31 2023-01-31 2020-A02886-33, 2020_52, COVID19-MHM, NCT04645498 Phase Not Applicable Not yet recruiting 1 24 Months 77 Claire Douillard, MD 2020-12-01
Comparing two medications (dexamethasone and methylprednisolone high dose) for the treatment of pneumonia in patients with COVID-19 Coronavirus disease 19 infection, Viral pneumonia Dexamethasone alone, methylprednisolone alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Clínica Medellín - Comprometidos con tu Salud Colombia 2020-04-01 2020-11-15 20-33686, ISRCTN33037282 Phase Not Applicable Completed 1 7 Months 213 Dr Pinzón 2020-12-03
Study of Longidaze in the Prevention and Treatment of Pulmonary Fibrosis, Interstitial Lung Diseases Caused by COVID-19 Coronavirus disease 19 infection, Interstitial lung disease, Pulmonary fibrosis Botkin.AI alone, bovhyaluronidase azoximer alone Hyaluronidase stimulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) NPO Petrovax Pharm LLC Kazakhstan, Russian Federation 2020-07-01 2021-07-31 DISSOLVE, NCT04645368 Phase Not Applicable Recruiting 16 13 Months 160 A. A. Zaycev, A. G. Borisov, A. U. Petuhova, G. L. Ignatova, L. I. Korneva, L. M. Kudelya, N. V. Kotova, Nikolay S. Dodonov, O. A. Chernyavskaya, O. A. Shagabutdinova, O. V. Masalkina, T. R. Kasyanova, T. V. Rubanik, U. V. Argamakova, V. V. Naumov 2020-12-01
SSC: SARS-CoV-2 Surveillance in childcare facilities Coronavirus disease 19 infection SARS-CoV-2 surveillance alone, saliva samples alone Uniklinik Köln - Zentrum Innere Medizin Germany 2020-11-29 20-1466, DRKS00023507, SSC Phase Not Applicable Recruiting 1 120 Felix Dewald 2020-12-01
A multicenter, single-blind, randomized controlled trial on ruxolitinb in treatment of severe coronavirus disease 2019 Coronavirus disease 19 infection ruxolitinib alone, standard-of-care alone Jak1 tyrosine kinase inhibitor, Jak2 tyrosine kinase inhibitor Cincinnati Children's Hospital Medical Center, Huazhong University of Science and Technology Phase 2 Clinical Status not specified 0 43 2020-12-08
Self-perceived depression, anxiety, stress in caregivers of patients in IKN during COVID-19 pandemic Acute stress disorder, Anxiety disorder, Coronavirus disease 19 infection, Depression Universiti Sains Malaysia Malaysia 2021-01-17 2021-10-17 57267, NMRR-20-2534-57267 Phase Not Applicable Status not specified 2 9 Months Sarah Aqilah Binti Ghazali 2020-11-30
The outcome of Pohon Sihat among healthcare workers during COVID-19 Coronavirus disease 19 infection Hospital Kuala Lumpur Malaysia 2021-01-01 2021-04-30 55907, NMRR-20-2568-55907 Phase Not Applicable Recruiting 1 4 Months 60 Hariani binti ishak 2020-11-30
DOSHHCW: COVID-19 Pandemic: determinants of occupational safety and health compliance among healthcare workers in Penampang and Putatan districts of Sabah Coronavirus disease 19 infection PEJABAT KESIHATAN KAWASAN PENAMPANG Malaysia 2020-12-01 2021-12-01 57340, DOSHHCW, NMRR-20-2554-57340 Phase Not Applicable Not yet recruiting 1 12 Months Dr Ahmad Firdaus bin Mohamed, Dr SAM FROZE ANAK JIEE 2020-12-06
New norms and PPE usage compliancy Coronavirus disease 19 infection Slim River Hospital Malaysia 2020-11-27 2021-01-26 57427, NMRR-20-2547-57427 Phase Not Applicable Status not specified 1 2 Months Dr Nur Hidayah Binti P.Azhar 2020-11-30
An observational, retrospective study to compare the outcome of metformin users and nonusers in hospitalized COVID-19 patients with diabetes Coronavirus disease 19 infection, Diabetes mellitus metformin hydrochloride alone AMP activated protein kinase stimulator Tongji Hospital, Huazhong University of Science and Technology China Phase Not Applicable Status not specified 1 283 2020-11-30
A Phase II, Randomized, Double-blinded, Placebo-controlled, Dose-finding Clinical Study to Evaluate the Safety and Immunogenicity of Different Doses of INO-4800 Administered Intradermally Followed by Electroporation in Healthy Adult and Elderly Volunteers Coronavirus disease 19 infection INO-4800 alone COVID19 Spike glycoprotein modulator Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Advaccine (Suzhou) Biopharmaceuticals Co Ltd, Jiangsu Province Centers for Disease Control and Prevention China 2020-11-27 2020-12-15 ChiCTR2000040146 Phase 2 Clinical Not yet recruiting 1 640 Fengcai Zhu, Xuefen Huai 2020-12-01
Eye Diseases associated with COVID-19 Choroid disease, Coronavirus disease 19 infection, Retinopathy bedside fundus examination alone, ophthalmoscopy alone, optical coherence tomography alone, optical coherence tomography angiography alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lilavati Hospital and Research Center India 2020-11-30 CTRI/2020/11/029393 Phase Not Applicable Not yet recruiting 1 30 Dr Salil Mehta 2020-12-02
A study of clinical profile of children with COVID-19 Infection admitted at tertiary care hospital Coronavirus disease 19 infection Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs) Smt. NHL Municipal Medical College India 2020-11-28 CTRI/2020/11/029390 Phase Not Applicable Not yet recruiting 1 200 DR Sweety Patel 2020-11-30
Virtual Enhanced Lifestyle for Metabolic Syndrome (ELM) Proof-of-Concept Study Coronavirus disease 19 infection, Metabolic syndrome X virtual enhanced lifestyle for metabolic syndrome program alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Rush University Medical Center Geisinger Clinic, Rochester Institute Of Technology, University of Colorado, University of Missouri US 2020-08-01 2021-03-30 20061108, NCT04637477 Phase Not Applicable No longer recruiting 2 7 Months 10 Lynda Powell, PhD 2020-12-01
Phase II, Multi-Site, Randomized, Placebo-Controlled, Double-Blind, Single-Dose Study of TY-027 for Early Treatment of COVID-19 Coronavirus disease 19 infection TY-027, Tychan alone Tychan Pte Ltd Singapore SCT-201 Phase 2 Clinical Status not specified 1 Dr Jenny Low 2020-11-30
XACT: Factor Xa Inhibitor Versus Standard of Care Heparin in Hospitalized Patients With COVID-19 Coronavirus disease 19 infection rivaroxaban alone Factor Xa antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) St. David's HealthCare US 2020-12-01 2021-07-31 2020-001708-41, NCT04640181, XACT Phase 2 Clinical Not yet recruiting 1 8 Months 150 Edward Chafizadeh, MD, Matt Cowperthwaite, PhD, Theresa Pham, MD 2020-12-10
Pirdal Nasal Spray in preventing symptomatic manifestation of disease in COVID-19 proven cases Coronavirus disease 19 infection, Respiratory distress syndrome Covispray (Vitro-Bio Sarl) alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Mudra Clincare, Vitro-Bio Sarl India 2020-11-27 CTRI/2020/11/029388, PIR/OBS/2020, Version No.: 4.0 Phase 2 Clinical Not yet recruiting 1 200 Dr S Sadgune, Dr Uma Mulay 2020-12-02
Evaluation of the efficacy and safety of bromhexine administration in COVID-19 Coronavirus disease 19 infection Variable regimens including bromhexine (Tolid Daru Company) , interferon beta-1a follow-on biologic (subcutaneous), CinnaGen , lopinavir + ritonavir (Hetero Labs Limited) Interferon beta ligand Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Shaheed Beheshti Medical University Iran 2020-07-10 IR.SBMU.NRITLD.REC.1399.142, IRCT20151227025726N24 Phase 2 Clinical No longer recruiting 1 100 Afshin Zarghi, Farzaneh Dastan, Payam Tabarsi 2020-11-30
A phase II clinical study to assess Persavita's experimental natural health product in the treatment of patients with COVID-19 Coronavirus disease 19 infection natural health product alone Persavita Ltd Canada Phase Not Applicable Planned 1 Dr Piraee 2020-11-27
Effect of cupping on respiratory symptoms of COVID-19 Coronavirus disease 19 infection, Respiratory disease cupping therapy alone, disposable plastic cup alone, standard medication therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Shaheed Beheshti Medical University Iran 2020-09-08 IR.SBMU.RETECH.REC.1399.563, IRCT20200428047229N3 Phase 3 Clinical No longer recruiting 1 72 Dr. Rasool Choopani, Hanieh Tahermohammadi, Zahra Aqanouri 2020-12-10
Formative research for management of serious infections in infants < 2 months of age during COVID pandemic Bacterial infection, Coronavirus disease 19 infection Healthy volunteers accepted Society for Applied Studies World Health Organization India 2020-12-15 CTRI/2020/11/029377 Phase Not Applicable Not yet recruiting 1 70 Nita Bhandari, Sarmila Mazumder 2020-11-30
An online study to assess the disposal of Personal protective equipments at home amid COVID-19 Pandemic in India Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Lady Hardinge Medical College India 2020-05-06 CTRI/2020/11/029376 Phase Not Applicable Completed 1 500 ARCHANA THAKUR 2020-11-30
Pentoxifyliine in COVID-19 Coronavirus disease 19 infection, Viral pneumonia Variable regimens including hydroxychloroquine , interferon beta-1b , lopinavir + ritonavir , pentoxyfylline, Arya company HIV protease inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Mazandaran University of Medical Sciences Iran 2020-11-10 IR.MAZUMS.REC.1399.744, IRCT20190804044429N4 Phase 2/Phase 3 Clinical Recruiting 1 60 Majid Saeedi, Monireh Ghazaeian 2020-12-02
A clinical study to compare high-flow nasal oxygen and non-invasive ventilation in patients with COVID-19 Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory failure high-flow nasal cannula therapy alone, non-invasive ventilation alone, oxygen alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) BLDE University Sri B. M. Patil Medical College India 2020-11-25 CTRI/2020/11/029356 Phase 2 Clinical Not yet recruiting 1 82 Dr Pratibha S D 2020-11-30
Assessing the knowledge and precautions taken by dentists and dental auxiliaries (operating, non-operating) in dental office during the pandemic of Corona virus (COVID-19) Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Manipal College of Dental Sciences India 2020-12-01 CTRI/2020/11/029350 Phase 2/Phase 3 Clinical Not yet recruiting 1 108 Dr Deepak Kumar Singhal, Dr Saloni Gupta 2020-11-30
Spectrum of eye infections in COVID-19 affected individuals Coronavirus disease 19 infection, Endophthalmitis, Panophthalmitis, Uveitis abscess drainage treatment alone, cycloplegic treatment alone, empirical intra-vitreal antibiotic therapy alone, exudation clearance treatment alone, intraocular antibiotic injection therapy alone, non steroidal anti inflammatory drug therapy alone, pars plana vitrectomy alone, silicone oil based retina attachment alone, steroid therapy alone, systemic broad spectrum antibiotic therapy alone, topical broad spectrum antibiotic therapy alone, vitreous biopsy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) L V Prasad Eye Institute India 2020-11-26 CTRI/2020/11/029346 Phase Not Applicable Not yet recruiting 1 20 Dr Sameera Nayak 2020-11-30
PCOVID: Clarithromycin in post Covid-19 parenchymal organizing pneumonia Coronavirus disease 19 infection, Respiratory disease, Viral pneumonia anti-tussive medication therapy alone, bronchodilator therapy alone, clarithromycin alone, mucolytics therapy alone, oral anti-fibrotic therapy alone, oral corticosteroid therapy alone, supplementary micronutrient therapy alone, clarithromycin plus oxygen Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Sri Ramachandra Hospital, Chennai India 2020-11-25 CTRI/2020/11/029305, PCOVID Phase 2 Clinical Not yet recruiting 1 120 Irfan Ismail Ayub 2020-12-01
The Efficacy and Safety of SCTA-01 in Hospitalized Patients With Severe COVID-19 Coronavirus disease 19 infection Best supportive care alone, SCTA-01 alone COVID19 Spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sinocelltech Ltd 2021-02-10 2021-10-10 NCT04644185, SCTA01-B301 Phase 2/Phase 3 Clinical Not yet recruiting 0 8 Months 795 Ji Qi, PhD, Zhanghua Lan, PhD 2020-11-30
Effectiveness of Pulmonary Rehabilitation Program in Patients With SARS-CoV-2 Pneumonia Anxiety disorder, Coronavirus disease 19 infection, Respiratory distress syndrome, Respiratory tract infection, Viral pneumonia alternate breathing alone, diaphragmatic breathing alone, early-mobilization and progressive ambulation alone, instructional exercise videos alone, joint ROM exercise alone, peripheral muscle strengthening exercises alone, pulmonary Rehabilitation program alone, pursed-lip breathing alone, respiratory muscle exercises alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Sisli Etfal Hospital Turkey 2020-06-30 2021-01-31 2857, NCT04642040 Phase Not Applicable Recruiting 1 7 Months 100 Ali Sahillioglu, MD, Enes Efe Is, MD 2020-11-30
Comparative Effectiveness of IIMR Versus CDSMP Bipolar disorder, Cardiac failure, Cardiovascular disease, Chronic obstructive pulmonary disease, Coronavirus disease 19 infection, Depression, Diabetes mellitus, Drug dependence, Hyperlipidemia, Hypertension, Obesity, Respiratory disease, Schizoaffective disorder, Schizophrenia Integrated Illness Management and Recovery alone, Stanford Chronic Disease Self-Management Program alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Dartmouth-Hitchcock Medical Center Patient Centered Outcome Research Institute US 2019-09-02 2024-03-31 D19103 31245, NCT03966872 Phase Not Applicable No longer recruiting 2 54 Months 600 Sarah Pratt 2020-12-01
Preoperative Covid-19 Screening In Otorhinolaryngolagy, Head And Neck Elective Surgery Coronavirus disease 19 infection, Surgical procedure Otorhinolaryngolagy alone Hospital Ampang Malaysia 2020-11-26 2020-12-31 57395, NMRR-20-2530-57395 Phase Not Applicable Status not specified 1 1 Month Dr NOR AZIRAH BINTI SALAHUDDIN 2020-11-30
The Role of Hemoperfusion as a Countermeasure for Cytokine Storm in COVID-19 Patients Admitted in a Public Tertiary Hospital in Davao City Coronavirus disease 19 infection Southern Philippines Medical Center Philippines 2020-03-01 PHRR201120-003164 Phase Not Applicable Not yet recruiting 1 Nian Joy T. Ibot, MD 2020-11-30
Development and Validation of Clinical Scoring for Predicting In-Hospital 30-day Mortality Among COVID-19 Patients in University of the Philippines – Philippine General Hospital: A Retrospective, Cohort Study Coronavirus disease 19 infection Philippine General Hospital Philippines 2020-08-10 2020-11-10 PHRR201120-003161 Phase Not Applicable No longer recruiting 1 3 Months Anna Flor Malundo, MD, Dr. Regina P. Berba MD, Karla Kristel A. Banares, MD, Karla Kristel Banares, Maria Sonia Salamat, MD, Marissa M. Alejandria, MD 2020-11-30
Tele-monitoring of COVID-19 Survivors for Long-Term Impacts Coronavirus disease 19 infection Custom-designed miniaturized monitoring system alone, Tele-monitoring alone, video-conferencing sessions alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Manitoba Function Four Ltd 2020-12-01 2021-11-01 B2020:114 (HS24395), NCT04644341 Phase Not Applicable Not yet recruiting 0 11 Months 20 Zahra Moussavi, Ph.D. 2020-11-30
Characteristics of novel coronavirus pneumonia (COVID-19) patients with mild nucleic acid in hospital for over 30 days Coronavirus disease 19 infection, Viral pneumonia Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) People's Hospital of Shapingba District, Chongqing City Chongqing Science and Technology Commission China 2020-09-30 2021-08-31 ChiCTR2000040179 Phase Not Applicable Not yet recruiting 1 11 Months 170 Huang Zi-Yang 2020-11-30
Safety and Pharmacokinetics of a Novel Niclosamide Solution in Combination With Camostat Coronavirus disease 19 infection niclosamide alone, camostat mesylate plus niclosamide Serine protease inhibitor, Transmembrane serine protease 2 inhibitor, Trypsin inhibitor Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) Charite Research Organisation Bayer AG Germany 2020-11-02 2021-05-31 201767, NCT04644705, NIC-002 Phase 1 Clinical Recruiting 1 6 Months 28 Frank D Wagner, Prof. Dr. med., Maximilian Posch, Dr. med. 2020-11-30
NeuroCovid: WHO Covid19- Neurological Abnormalities in SARS-CoV-2 ICU Patients Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Clermont-Ferrand France 2020-10-13 2021-08-13 NCT04643548, NEUROCOVID-RNI 2020 GODET, NeuroCovid Phase Not Applicable Recruiting 1 10 Months 20 Benjamin Rieu, Lise Laclautre, Thomas Godet 2020-12-02
A phase II study to evaluate safety and effectiveness of IND-02 capsules in patients who are hospitalized SARS-CoV2 positive patients with mild to moderate COVID-19 at COVID management centers offering ayurvedic care Coronavirus disease 19 infection IND-02 alone, standard of care treatment alone ApoB editing catalytic polypeptide 3G modulator, HIV gp120 protein modulator Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs) IQVIA RDS (India) Pvt Ltd, Indus Biotech Pvt Ltd India 2020-11-30 CTRI/2020/11/029328, IND02-ORAL-COVID-19 Version 1.0 Phase 2 Clinical Not yet recruiting 5 118 Dr Ajay Javeri, Dr Amlendu Yadav, Dr Amol Laxmanrao Dange, Dr Jaya Prakash Appajigol, Dr Shrikant Deshpande, Suneela Thatte 2020-11-30
Differential Leukocyte Count and Covid-19 Diagnosis Coronavirus disease 19 infection CLDC algorithm alone, Differential leukocyte count (CLDC) device alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Istituto Neurologico Mediterraneo NEUROMED Italy 2020-12-31 2021-05-31 DEP_042020, NCT04643860 Phase Not Applicable Not yet recruiting 2 5 Months 1000 Licia Iacoviello 2020-12-01
Mask Adhesive Institutional Study Coronavirus disease 19 infection, Respiratory failure AF531 non-invasive ventilation mask (Philips) alone, PerformaTrak non-invasive ventilation mask (Philips) alone, mask adhesive (Philips) alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Royal Philips Electronics US 2020-11-17 2020-12-17 NCT04644276, SRCHRCMASK ADHESIVE 2020_11130 Phase Not Applicable Not yet recruiting 1 1 Month 30 Robert Doekel, Wes Booth 2020-11-30
Telerehabilitation Following Meniscectomy Coronavirus disease 19 infection, Knee injury knee exercises alone, meniscectomy alone, proprioception and balance training alone, telerehabilitation therapy alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) NYU Langone Health US 2020-12-01 2022-12-01 20-01584, NCT04644640 Phase Not Applicable Not yet recruiting 1 24 Months 60 Eoghan Hurley, MB, BCh, MCh, Eric Strauss, MD, Guillem Gonzalez-Lomas, MD, Kirk Campbell, MD, Laith Jazrawi, MD, Michael Alaia, MD 2020-11-26
Apprehensions and challenges faced by dentists during Covid-19 pandemic Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Manipal College of Dental Sciences India 2020-12-02 CTRI/2020/11/029335 Phase Not Applicable Not yet recruiting 1 189 Dr Sunitha Carnelio, Muskaan Chichra 2020-11-30
Improving Thinking in Everyday Life After Covid-19 Cognitive disorder, Coronavirus disease 19 infection instrumental activities of daily living shaping alone, speed of processing training alone, transfer package alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University of Alabama at Birmingham US 2020-11-01 2024-11-30 IRB-300002814C, NCT04644172 Phase 1/Phase 2 Clinical Recruiting 1 49 Months 40 Edward Taub, Edward Taub, Ph.D., Staci McKay 2020-12-01
Brief Video Interventions for Depression Coronavirus disease 19 infection, Depression video-based intervention on behavioral emotion regulation skill alone, video-based intervention on cognitive emotion regulation skill alone, video-based intervention on interpersonal emotion regulation skill alone, video-based intervention on three emotion regulation skill alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Ohio State University US 2020-11-30 2020-11-30 2020B0326, NCT04643964 Phase Not Applicable Recruiting 1 501 Daniel R Strunk, Ph.D., Graham C Bartels, B.S., Jennifer S Cheavens, PhD, Robert J Zhou, B.A. 2020-11-30
Effects of a Biomechanical-based Tai Chi Program on Gait and Posture in People With Parkinson's Disease Coronavirus disease 19 infection, Parkinsons disease Tai Chi training alone Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University of Ottawa Canada 2021-01-31 2021-12-31 H-01-19-2284, NCT04644367 Phase Not Applicable Not yet recruiting 1 11 Months 40 Jing Xian Li, PhD., Nok-Yeung Law, Nok-Yeung Law, M.Sc. 2020-12-01
Using Travelan to Boost Immune Response in Vitro to COVID-19 Coronavirus disease 19 infection Travelan alone Healthy volunteers accepted, Male, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hadassah Medical Organization Israel 2020-11-01 2020-12-31 HEALTHYTRAVELANCOV19- HMO-CTIL, NCT04643561 Phase 1/Phase 2 Clinical No longer recruiting 1 2 Months 5 Assaf Potruch, MD 2020-11-30
The Doctors for Coronavirus Prevention Project Thanksgiving Messaging Campaign Coronavirus disease 19 infection Facebook Ads alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) National Bureau of Economic Research Inc Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology, Stanford University, Yale University US 2020-11-14 2021-11-26 2003000118A010, NCT04644328 Phase Not Applicable Not yet recruiting 1 12 Months 20000000 Esther Duflo 2020-11-26
Management of Type 1 Supracondylar Humeral Fractures Coronavirus disease 19 infection, Upper limb fracture long arm soft casting alone Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs) University of British Columbia Lady Cilento Children's Hospital Canada 2021-01-31 2023-01-31 H20-02942, NCT04642807 Phase Not Applicable Not yet recruiting 1 24 Months 52 Anthony Cooper, Anthony Cooper, FRCSC, Harpreet Chhina, MSc 2020-12-01
Convalescent Plasma Transfusion in Severe COVID-19 Patients in Jamaica Coronavirus disease 19 infection convalescent plasma alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University of the West Indies Jamaica 2020-12-01 2021-12-01 ECP/195,19/20, NCT04644198 Phase 2 Clinical Not yet recruiting 1 12 Months 30 Gilian G Wharfe, Giliian G Wharfe, MB, BS, DM, Tomlin Paul 2020-11-30
COVID-OISE: Longitudinal Follow-up of a Population Cohort in a French City With High SARS-CoV-2 Circulation in Early 2020 (COVID 19) Coronavirus disease 19 infection Healthy volunteers accepted, Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Institut Pasteur France 2020-11-13 2023-11-01 2020-060, COVID-OISE, NCT04644159 Phase Not Applicable Recruiting 2 35 Months 2000 Aymar KOFFI, Dr, Bruno HOEN, Pr, Cécile DURU, Dr, Laurie Pinaud, Marie-Noëlle UNGEHEUER,, Sandrine Fernandes Pellerin 2020-12-01
Develop homeopathic Nosodes for Immunity Against COVID 19 Coronavirus disease 19 infection nosode alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Central Council for Research in Homeopathy Ministry of Ayush, National Cancer Institute, Jhajjar, AIIMS India 2020-12-10 CTRI/2020/11/029399 Phase 1 Clinical Not yet recruiting 1 20 Dr Naval Kumar Verma, Dr Sushma Bhtanagar 2020-11-28
Palliative Care in COVID-19 Coronavirus disease 19 infection Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Kasturba Medical College and Hospital India 2020-12-07 CTRI/2020/11/029398 Phase Not Applicable Not yet recruiting 1 50 Seema Rajesh Rao 2020-11-28
Changing Trends in Presentation of Trauma Patients during Nationwide lockdown for COVID-19 Coronavirus disease 19 infection, Injury Newborn Infants (up to 5 months), Infants (6-23 months), Preschool Children (2-5 yrs), Children (6-12 yrs), Adolescents (13-17 yrs), Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) HBTMC and Dr RN Cooper Municipal General Hospital India 2020-12-01 CTRI/2020/11/029297 Phase Not Applicable Not yet recruiting 1 100 Vipul Versi Nandu 2020-12-01
Study to Assess Adverse Events and How Intravenous ABBV-47D11 Moves Through the Body of Adult Participants Hospitalized With Coronavirus Disease 2019 (COVID-19) Coronavirus disease 19 infection, Lower respiratory tract infection 47D-11 alone COVID19 Spike glycoprotein inhibitor Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) AbbVie Inc US 2020-11-27 2021-05-01 2020-005203-39, M20-404, NCT04644120 Phase 1 Clinical Not yet recruiting 11 5 Months 24 ABBVIE CALL CENTER, AbbVie Inc. 2020-12-14
Safety of an aerosol having as its active ingredient 8.4% sodium bicarbonate and xylitol 5% when administered to the nasopharynx and oropharynx Coronavirus disease 19 infection, Influenza virus infection Variable regimens including benzalkonium chloride , glycerine , propylene glycol , sodium bicarbonate , xylitol Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) DR BHARAT MODY, Myself Health Check Ltd Welcare Hospital India 2020-12-01 CTRI/2020/11/029396 Phase 2 Clinical Not yet recruiting 1 325 Dr Kshitij Mody, Dr Manoj Parmar, Dr Vidhi Hingu 2020-12-02
Semen Parameters and COVID-19 in Infertile Men Coronavirus disease 19 infection, Male infertility reverse transcriptase polymerase chain reaction test alone, spermiogram analysis alone Male, Young Adults (18-44 yrs) Ankara City Hospital Bilkent Turkey 2020-01-07 2020-10-10 E1-20-1237, NCT04643522 Phase Not Applicable Completed 1 9 Months 21 Erdem Koc 2020-12-01
Precautionary measure during surgical process during COVID-19 pandemic around the globe Coronavirus disease 19 infection FFP-2 mask alone, N-95 mask alone, nasal prongs alone, oxygen therapy alone, suction cannula alone Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Harsiddhi Cosmetic and Plastic Surgery Hospital India 2020-12-01 CTRI/2020/11/029394 Phase Not Applicable Not yet recruiting 1 30 Dr Pradipkumar Raghuvirsinh Atodaria 2020-12-02
Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis Coronavirus disease 19 infection, Sepsis microcirculation recording alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) University Hospital Hradec Kralove Czech Republic 2020-02-01 2021-12-31 FNHK_IGS_8144, NCT04644302 Phase Not Applicable Recruiting 1 23 Months 25 David Astapenko, M.D., Pavel Dostal, M.D., Ph.D., MBA, Vladimir Cerny, Vladimir Cerny, prof. 2020-12-01
Anakinra in the Management of COVID-19 Infection Coronavirus disease 19 infection, Respiratory distress syndrome, Viral pneumonia Standard of care alone, anakinra alone Type I IL-1 receptor antagonist Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Hamad Medical Corp Qatar 2020-10-30 2021-10-30 MRC-05-140, NCT04643678 Phase 2/Phase 3 Clinical Recruiting 1 12 Months 80 Dr. Eman Elmekaty, PharmD 2020-12-09
Iodine treatment Coronavirus infection Coronavirus disease 19 infection iodine alone Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs), Elderly Adults (80 and over) Maxima Medisch Centrum Veldhoven Netherlands 2020-07-14 01-04-2020, 2020-001852-16 Phase 2 Clinical Recruiting 1 224 reumatology department 2020-11-27
PoliCOV: Police COVID-19 Serosurvey Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) University of Bern Blutspendedienst SRK Bern AG Switzerland 2021-01-31 2022-06-30 2020-02650, NCT04643444, PoliCOV Phase Not Applicable Not yet recruiting 2 17 Months 1000 Parham Sendi, MD 2020-12-01
COVIDGEN: Genetic Predisposition to Severe Forms of COVID-19 (SARS-CoV2 Infection) Coronavirus disease 19 infection Healthy volunteers accepted, Young Adults (18-44 yrs), Middle-aged Adults (45-64 yrs), Aged Adults (65-79 yrs) Hospices Civils De Lyon France 2020-12-01 2021-12-01 69HCL20_1072, COVIDGEN, NCT04644146 Phase Not Applicable Recruiting 1 12 Months 40 Alain CALENDER, MD 2020-11-27
Inflammatory Markers and Hematological Indices in the Prediction of Severity of COVID-19: A Single Center Study in Southern Philippines Coronavirus disease 19 infection Southern Philippines Medical Center Philippines 2020-11-30 2021-04-30 PHRR201117-003152 Phase Not Applicable Not yet recruiting 1 5 Months Meccar Moniem Haradji Elino 2020-11-27